223,541 results match your criteria Advances in Peritoneal Dialysis[Journal]


The state of bereavement support in adult intensive care: A systematic review and narrative synthesis.

J Crit Care 2018 Dec 1;50:177-187. Epub 2018 Dec 1.

University of Ottawa, Faculty of Health Sciences, School of Nursing, 3245B Roger Guindon Hall, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada. Electronic address:

Purpose: Despite advances in medical science, patient death and family bereavement are commonly encountered in adult intensive care units (ICUs). This is the first review to investigate the state of ICU bereavement support globally, and the availability and effectiveness of bereavement support interventions.

Methods: A systematic review and narrative synthesis. Read More

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December 2018
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Recent advances in bio-affinity chromatography for screening bioactive compounds from natural products.

J Pharm Biomed Anal 2018 Dec 7;165:182-197. Epub 2018 Dec 7.

Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China. Electronic address:

Natural products are one of the most important sources of leading compounds in drug discovery. Until now, rapid screening and identification of biologically active components from natural products remain a technical challenge. Bio-affinity chromatography (BAC) based approaches hold great promise in screening potential bioactive ligands from complex samples. Read More

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December 2018

A decade of Nucleic Acid Programmable Protein Arrays (NAPPA) availability: News, actors, progress, prospects and access.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Proteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain; Department of Medicine and General Cytometry Service-Nucleus, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain. Electronic address:

Understanding the dynamic of the proteome is a critical challenge because it requires high sensitive methodologies in high-throughput formats in order to decipher its modifications and complexity. While molecular biology provides relevant information about cell physiology that may be reflected in post-translational changes, High-Throughput (HT) experimental proteomic techniques are essential to provide valuable functional information of the proteins, peptides and the interconnections between them. Hence, many methodological developments and innovations have been reported during the last decade. Read More

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December 2018

A generative model of realistic brain cells with application to numerical simulation of the diffusion-weighted MR signal.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Centre for Medical Image Computing and Dept of Computer Science, University College London, London, UK.

To date, numerical simulations of the brain tissue have been limited by their lack of realism and flexibility. The purpose of this work is to propose a controlled and flexible generative model for brain cell morphology and an efficient computational pipeline for the reliable and robust simulation of realistic cellular structures with application to numerical simulation of intra-cellular diffusion-weighted MR (DW-MR) signal features. Inspired by the advances in computational neuroscience for modelling brain cells, we propose a generative model that enables users to simulate molecular diffusion within realistic digital brain cells, such as neurons, in a completely controlled and flexible fashion. Read More

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December 2018

Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Salivary gland cancers represent a rare group of tumors composed by over 20 histological subtypes. Initially treated as one single disease, its diagnosis, prognosis, and treatment are currently being stratified based on morphology. More recently, insight has been provided on the molecular characterization of each subtype, further improving diagnostic accuracy and paving the way for personalized therapy. Read More

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December 2018
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Key Elements in Adverse Drug Reactions Safety Signals: Application of Legal Strategies.

Cancer Treat Res 2019 ;171:47-59

University of South Carolina, Columbia, SC, USA.

Adverse drug reactions, or unintended and harmful outcomes related to the administration of a pharmaceutical product, are a major public health concern, particularly for cancer patients. If counted as a separate cause of death, adverse drug reactions would represent the fourth leading cause of death in the United States. Several legal strategies are available to help mitigate their occurrences and to compensate victims for the harm that results from adverse events. Read More

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January 2019
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Rational combination of cancer immunotherapy in melanoma.

Virchows Arch 2018 Dec 14. Epub 2018 Dec 14.

Maria Sklodowska-Curie Institute, Oncology Center, Warsaw, Poland.

The recent advances in cancer immunotherapy with unprecedented success in therapy of advanced melanoma represent a turning point in the landscape of melanoma treatment. Given the complexity of activation of immunological system and the physiologic multifactorial homeostatic mechanisms controlling immune responses, combinatorial strategies are eagerly needed in melanoma therapy. Nevertheless, rational selection of immunotherapy combinations should be more biomarker-guided, including not only the cancer immunogram, PD-L1 expression, interferon gene expression signature, mutational burden, and tumor infiltration by CD8+ T cells but also intratumoral T cell exhaustion and microbiota composition. Read More

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December 2018
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Recent Advances on Relationship Between Inorganic Phosphate and Pathologic Calcification: Is Calcification After Breast Augmentation with Fat Grafting Correlated with Locally Increased Concentration of Inorganic Phosphate?

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, China.

Background: Pathologic calcification has frequently occurred after breast augmentation with fat grafting as well as other conditions such as breast cancer, trauma, myocardial infarction, arteriosclerosis and even after reduction mammoplasty. Inorganic phosphate, correlated with fat metabolism, is an important factor that induces pathologic calcification such as vascular calcification.

Methods: A literature search was conducted using PubMed with the keywords: calcification, inorganic phosphate, fat. Read More

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December 2018

Supported self-management for people with type 2 diabetes: a meta-review of quantitative systematic reviews.

BMJ Open 2018 Dec 14;8(12):e024262. Epub 2018 Dec 14.

Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

Objectives: Self-management support aims to give people with chronic disease confidence to actively manage their disease, in partnership with their healthcare provider. A meta-review can inform policy-makers and healthcare managers about the effectiveness of self-management support strategies for people with type 2 diabetes, and which interventions work best and for whom.

Design: A meta-review of systematic reviews of randomised controlled trials (RCTs) was performed adapting Cochrane methodology. Read More

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December 2018

Qualitative exploration of sociocultural determinants of health inequities of Dalit population in Dhaka City, Bangladesh.

BMJ Open 2018 Dec 14;8(12):e022906. Epub 2018 Dec 14.

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Objectives: In recent years, Bangladesh has made remarkable advances in health outcomes; however, the benefits of these gains are unequally shared among citizens and population groups. Dalits ( sweepers), a marginalised traditional working community, have relatively poor access to healthcare services. This study sought to explore the sociopolitical and cultural factors associated with health inequalities among Dalits in an urban setting. Read More

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December 2018

Development of an Electronic Data Collection System to Support a Large-Scale HIV Behavioral Intervention Trial: Protocol for an Electronic Data Collection System.

JMIR Res Protoc 2018 Dec 14;7(12):e10777. Epub 2018 Dec 14.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States.

Background: Advancing technology has increased functionality and permitted more complex study designs for behavioral interventions. Investigators need to keep pace with these technological advances for electronic data capture (EDC) systems to be appropriately executed and utilized at full capacity in research settings. Mobile technology allows EDC systems to collect near real-time data from study participants, deliver intervention directly to participants' mobile devices, monitor staff activity, and facilitate near real-time decision making during study implementation. Read More

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December 2018

Oesophagectomy: The expanding role of minimally invasive surgery in oesophageal cancer.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:75-80. Epub 2018 Nov 21.

Department of Upper GI Surgery and General Surgery, Norfolk and Norwich University Hospital, Colney Lane, NR4 7UY, Norwich, United Kingdom. Electronic address:

Historically, open oesophagectomy was the gold standard for oesophageal cancer surgery. This was associated with a relatively higher morbidity. In the last two decades, we have seen significant improvements in short and long term outcomes due to centralisation of oesophagectomy, multidisciplinary approach, enhanced recovery after surgery programmes, neoadjuvant treatments and advances in minimally invasive oesophagectomy (MIO) techniques. Read More

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November 2018

Neoadjuvant chemoradiotherapy for resectable oesophageal cancer.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:37-44. Epub 2018 Nov 22.

Department of Surgery, Erasmus MC - University Medical Centre Rotterdam, Dr. Molenwaterplein 40, 3000 CA, Rotterdam, the Netherlands.

At present, treatment of potentially curable oesophageal cancer includes neoadjuvant chemoradiotherapy followed by oesophagectomy. Alternatively, neoadjuvant chemotherapy is used. To date, strong evidence on the superiority of one modality over the other has not been provided. Read More

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November 2018

Endoscopic management of dysplasia and early oesophageal cancer.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:27-36. Epub 2018 Nov 23.

Dept of Gastroenterology, Guy's & St Thomas' Hospitals NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, United Kingdom.

In the past decade there have been technological advances in Endoscopic Eradication Therapy (EET) for the management of patients with oesophageal neoplasia and early cancer. Multiple endoscopic techniques now exist for both squamous and Barrett's oesophagus associated neoplasia or early cancer. A fundamental aspect of endotherapy is removal of the target lesion by endoscopic mucosal resection, or endosopic submucosal dissection. Read More

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November 2018

Oral medicine: Today's future can become tomorrow's reality.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Nov 22;126(5):409-414. Epub 2018 Aug 22.

Professor and Head, Oral Medicine, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine; Co-chair, Head & Neck Cancer/Oral Oncology Program, Neag Comprehensive Cancer Center, UConn Health Farmington, CT, USA.

There have been strategic clinical, educational, and research advances in the field of Oral Medicine over the past several decades. In many cases, Oral Medicine experts are contributing the lead role in these advances nationally and internationally. In addition, American Board of Dental Specialty recognition of Oral Medicine as a specialty in 2015 has positioned Oral Medicine professionals to substantively enhance the delivery of oral health care to medically complex patients as well. Read More

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November 2018

Recent advances in antimicrobial and bacterial resistance.

Int J Antimicrob Agents 2018 Dec;52(6):869-870

Laboratoire Neurophysiologie, Physiopathologie Cellulaire et Valorisation des BioMolécules, Faculté des Sciences de Tunis, Université de Tunis El-Manar, Campus Universitaire, 2098 El-Manar II, Tunisia.

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December 2018

Social nutrition: an emerging field in insect science.

Curr Opin Insect Sci 2018 Aug 18;28:73-80. Epub 2018 May 18.

School of Agriculture, Food and Wine, The University of Adelaide, Waite Campus, Southern Australia 5005, Australia.

Nutrition is thought to be a major driver of social evolution, yet empirical support for this hypothesis is scarce. Here we illustrate how conceptual advances in nutritional ecology illuminate some of the mechanisms by which nutrition mediates social interactions in insects. We focus on experiments and models of nutritional geometry and argue that they provide a powerful means for comparing nutritional phenomena across species exhibiting various social ecologies. Read More

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August 2018
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RAD-ical New Insights into RAD51 Regulation.

Genes (Basel) 2018 Dec 13;9(12). Epub 2018 Dec 13.

Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

The accurate repair of DNA is critical for genome stability and cancer prevention. DNA double-strand breaks are one of the most toxic lesions; however, they can be repaired using homologous recombination. Homologous recombination is a high-fidelity DNA repair pathway that uses a homologous template for repair. Read More

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December 2018

Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Research Programs Unit, Genome-Scale Biology, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland.

Diabetic retinopathy (DR) is the most common diabetic microvascular complication and major cause of blindness in working-age adults. According to the level of microvascular degeneration and ischemic damage, DR is classified into non-proliferative DR (NPDR), and end-stage, proliferative DR (PDR). Despite advances in the disease etiology and pathogenesis, molecular understanding of end-stage PDR, characterized by ischemia- and inflammation-associated neovascularization and fibrosis, remains incomplete due to the limited availability of ideal clinical samples and experimental research models. Read More

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December 2018
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Geometric Effect for Biological Reactors and Biological Fluids.

Bioengineering (Basel) 2018 Dec 13;5(4). Epub 2018 Dec 13.

Department of Physics, Kyushu University, Fukuoka 819-0395, Japan.

As expressed "God made the bulk; the surface was invented by the devil" by W. Pauli, the surface has remarkable properties because broken symmetry in surface alters the material properties. In biological systems, the smallest functional and structural unit, which has a functional bulk space enclosed by a thin interface, is a cell. Read More

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December 2018

Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects.

High Throughput 2018 Dec 13;7(4). Epub 2018 Dec 13.

Departments of Pathology and Pediatric Hematology-Oncology, University of Missouri School of Medicine, Kansas City, MO 64108, USA.

Precision oncologic medicine is an emerging approach for cancer treatment that has recently taken giant steps in solid clinical practice. Recent advances in molecular diagnostics that can analyze the individual tumor's variability in genes have provided greater understanding and additional strategies to treat cancers. Although tumors can be tested by several molecular methods, the use of next-generation sequencing (NGS) has greatly facilitated our understanding of pediatric cancer and identified additional therapeutic opportunities. Read More

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December 2018

The arrival of predictive biomarkers for monitoring therapy response to natural compounds in cancer drug discovery.

Biomed Pharmacother 2019 Jan 1;109:2492-2498. Epub 2018 Dec 1.

Faculty of Medicine and Pharmacy, Mohamed I(st) University, Oujda, Morocco; Department of Medical Oncology, Mohamed VI University Hospital, Oujda, Morocco.

Intrinsic or acquired drug resistance, adverse drug reactions and tumor heterogeneity between and within cancer patients limit the efficacy of clinical management of advanced cancers. To overcome these barriers, predictive biomarkers have recently emerged to guide medical oncologists in the selection of cancer patients who will respond to various anticancer treatments and to improve the toxicity to benefit ratio. Notably, targeted therapy has significantly benefited from these advances, but the application of predictive biomarkers have been a bit slower with some drugs derived from natural sources such as trabectedin, cabazitaxel and alvocidib. Read More

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January 2019

Mesoporous silica nanoparticles for therapeutic/diagnostic applications.

Biomed Pharmacother 2019 Jan 6;109:1100-1111. Epub 2018 Nov 6.

Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address:

Based on unique intrinsic properties of mesoporous silica nanoparticles (MSNs) such as high surface area, large pore size, good biocompatibility and biodegradability, stable aqueous dispersion, they have received much attention in the recent decades for their applications as a promising platform in the biomedicine field. These porous structures possess a pore size ranging from 2 to 50 nm which make them excellent candidates for various biomedical applications. Herein, at first we described the common approaches of cargo loading and release processes from MSNs. Read More

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January 2019

Recent advances in nano-bio-interactions: Editorial.

Colloids Surf B Biointerfaces 2019 Jan 25;173:906. Epub 2018 Oct 25.

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700, Fribourg, Switzerland. Electronic address:

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January 2019

Advances in aspirin-exacerbated respiratory disease (AERD).

Nihon Rinsho 2016 Oct;74(10):1683-1687

Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, eosinophilic nasal polyposis and a hypersensitivity to all medications that inhibit the cyclo- oxygenase (COX) -1 enzyme. Clinical history and observed aspirin provocation test remains gold standard for diagnosis of AERD. AERD patients typically have more severe asthma with airflow limitation and greater requirement for high-dose corticosteroid therapies. Read More

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October 2016

Recent advances in research on chronic active EB virus infection.

Authors:
Hiroshi Kimura

Nihon Rinsho 2016 Nov;74(11):1917-1924

Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that is associated with a variety of malignancies. Chronic active virus infection (CAEBV) is an EBV-associated T or NK cell lymphoproliferative diseases that occur most often in children and young adults in East Asia. It is still not known why this ubiquitous virus causes CAEBV in certain individuals. Read More

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November 2016

Current status and future perspective of the chemotherapy for colorectal cancer.

Nihon Rinsho 2016 Nov;74(11):1852-1856

In the last decade unprecedented advances have been seen in the treatment of metastatic colorectal cancer(mCRC). Clinical developments of many active agents have contributed to this great progress in the prognosis of mCRC. Recently, new active agents and combination chemotherapies have been developed and reported promising results for HER2 positive, BRAF mutant, and MSI-High mCRC patients. Read More

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November 2016

Colorectal cancer-the history and current status of clinical and research-.

Nihon Rinsho 2016 Nov;74(11):1781-1785

The history of clinical and research of colorectal cancer, beginning from surgery therapy, a variety of fields have evolved from there, the results have been stacked. Safety of the establishment and the usefulness of the proof of the surgery, the development of diagnostic methods, advances in chemotherapy, the discovery of hereditary colon cancer, due to the development and application of basic research to support these, research and treatment results for colorectal cancer. It has been made great strides. Read More

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November 2016

Diagnostics and therapeutics for Ebola hemorrhagic fever: application of monoclonal antibody.

Authors:
Ayato Takada

Nihon Rinsho 2016 Dec;74(12):2080-2085

Ebolaviruses, members of the family Filoviridae, cause severe hemorrhagic fever (Ebola virus disease: EVD) in humans and nonhuman primates with case fatality rates of up to 90%. No effective prophylaxis or treatment for EVD is yet commercially available. The latest out- break of EVD in West Africa has highlighted the urgent need for the development of thera- peutics and diagnostics. Read More

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December 2016

Advances and opportunities for the design of self-sufficient and spatially organized cell-free biocatalytic systems.

Curr Opin Chem Biol 2018 Dec 11;49:97-104. Epub 2018 Dec 11.

Heterogeneous biocatalysis laboratory, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH-CSIC), University of Zaragoza, C/ Pedro Cerbuna 12, 50009, Zaragoza, Spain; ARAID, Aragon I+D foundation, Zaragoza, Spain. Electronic address:

During the past decades, biocatalysis has made important contributions to chemical manufacturing by using both whole-cell and cell-free biotransformation reactions. More recently, multi-enzyme systems that can run step-wise reactions in one-pot with high selectivity are increasingly being developed. The use of multiple isolated enzymes to perform a series of reactions offers operational and process advantages over the use of living or resting cells, but such cell free processes need to be optimized to meet industrial productivity and titer requirements. Read More

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December 2018
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Integrating multilocus DNA data and 3D geometric morphometrics to elucidate species boundaries in the case of Pyrenaearia (Pulmonata: Hygromiidae).

Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.

Department of Zoology and Animal Cell Biology, Faculty of Pharmacy, University of the Basque Country, EHU/UPV, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Araba, Spain; Biodiversity Research Group CIEA Lucio Lascaray, Avda. Miguel de Unamuno 3, 01006, Araba, Spain. Electronic address:

To accurately delimit species the use of multiple character types is essential as all speciation processes are not equally reflected in different data (e.g. morphological, molecular or ecological characters). Read More

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December 2018

m6A modification of non-coding RNA and the control of mammalian gene expression.

Biochim Biophys Acta Gene Regul Mech 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

The biology of non-coding RNA (ncRNA) and the regulation of mammalian gene expression is a rapidly expanding field. In this review, we consider how recent advances in technology, enabling the precise mapping of modifications to RNA transcripts, has provided new opportunities to dissect post-transcriptional gene regulation. With this has come the realisation that in the absence of translation, the modification of ncRNAs may play a fundamental role in their regulation, protein interactome and subsequent downstream effector functions. Read More

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December 2018

Cancer Neoantigens.

Annu Rev Immunol 2018 Dec 14. Epub 2018 Dec 14.

Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; email: ,

Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell-based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint blockade and adoptive T cell therapy as cancer immunotherapies. Read More

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December 2018
1 Read

Reversing wetland death from 35,000 cuts: Opportunities to restore Louisiana's dredged canals.

PLoS One 2018 14;13(12):e0207717. Epub 2018 Dec 14.

University of Central Florida, Orlando, Florida, United States of America.

We determined the number of permits for oil and gas activities in 14 coastal Louisiana parishes from 1900 to 2017, compared them to land loss on this coast, and estimated their restoration potential. A total of 76,247 oil and gas recovery wells were permitted, of which 35,163 (46%) were on land (as of 2010) and 27,483 of which are officially abandoned. There is a direct spatial and temporal relationship between the number of these permits and land loss, attributable to the above and belowground changes in hydrology resulting from the dredged material levees placed parallel to the canal (spoil banks). Read More

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December 2018
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Dissecting the regulation and function of ATP at the single-cell level.

PLoS Biol 2018 Dec 14;16(12):e3000095. Epub 2018 Dec 14.

Center for Quantitative Biology and Peking-Tsinghua Joint Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Regulation of cellular ATP level is critical for diverse biological processes and may be defective in diseases such as cancer and mitochondrial disorders. While mitochondria play critical roles in ATP level regulation, we still lack a systematic and quantitative picture of how individual mitochondrial-related genes contribute to cellular ATP level and how dysregulated ATP levels may affect downstream cellular processes. Advances in genetically encoded ATP biosensors have provided new opportunities for addressing these issues. Read More

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December 2018

Current Practices in the Processing, Diagnosis, and Reporting of Endometrial Carcinoma: Results of a Web-based Survey by the International Society of Gynecological Pathologists (ISGyP).

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S3-S8

Department of Pathology and Obstetrics and Gynecology, Yale School of Medicine and the Yale School of Public Health, New Haven, Connecticut (V.P.) Department of Pathology, Hospital University Arnau de Vilanova and University de Bellvitge, Irblleida, Idibell, University of Lleida, Ciberonc, Lleida, Spain (X.M.G.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (E.O.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.).

There have been significant advances in our understanding of the biology and classification of endometrial carcinoma, over the last few years, and the new prediction models proposed for prognostication. To accurately diagnose and stage tumors and apply these prediction models, it is necessary that there be standardized processing of specimens, and a common understanding and usage of the diagnostic terminology of endometrial carcinoma. The International Society of Gynecological Pathologists embarked on an ambitious project to achieve this goal in 2015. Read More

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January 2019

Lipoprotein metabolism in liver diseases.

Curr Opin Lipidol 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: The liver is the central hub of lipoprotein metabolism. A complex relationship exists between dyslipidemia and chronic liver diseases (CLDs). Recent advances in the genetics of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) exemplify the pivotal role of lipoprotein metabolism in the pathogenesis of CLD. Read More

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December 2018
1 Read

Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.

Syst Biol Reprod Med 2018 Dec 14:1-16. Epub 2018 Dec 14.

b Division of Pharmacology and Toxicology , CSIR- Indian Institute of Chemical Technology , Hyderabad , India.

We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). Read More

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December 2018

[Advances in osteoradionecrosis of nasopharynx after radiotherapy for nasopharyngeal carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1839-1842

Radiation therapy is the first choice for the treatment of nasopharyngeal carcinoma. However, it is inevitable that nasopharyngeal mucosa and tissue will be damaged after radiotherapy of nasopharyngeal carcinoma, which will cause corresponding complications. Nasopharyngeal osteonecrosis is a serious complication. Read More

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December 2018
1 Read

[Research progress of biologics in the treatment of chronic rhinosinusitis].

Authors:
Y Liu F Yuan

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1515-1518

Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal airways and paranasal sinuses. The condition is defined by more than 12 weeks of nasal obstruction, nasal discharge, facial pain/pressure, and reduced/lost smell. CRS is commonly further classified into 2 subsets based on its clinical phenotype: those with polyps (CRSwNP) and those without (CRSsNP). Read More

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October 2018

[Advances in the treatment of tinnitus].

Authors:
D Wu Y Zheng T Xiang

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1436-1440

Tinnitus is the perception of sound without an external source. Its impact is wide-ranging and heterogeneous across individuals. Since tinnitus is a subjective sensation, the treatment of tinnitus is still in the research and exploration stage at present. Read More

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September 2018

[Advances in prevention of pharyngocutaneous fistula after total laryngectomy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1917-1922

Total laryngectomy is a common method for the treatment of malignant tumors of the pharynx and larynx in China, but pharyngocutaneous fistula often happens after surgery, which burdens patients and affects postoperative recovery. At present, there are many measures to prevent pharyngocutaneous fistula, including strengthening nutrition pre-operative and post-operative, testing related indicators, controlling comorbidities, rational use of drugs, regular oral care, optimal selection of incision closure, and using of flaps and special materials during operation, etc. However, the choice of specific program needs to take care of the patient's condition, surgeon's skills and hospital conditions, and often requires multiple programs to be used together throughout the perioperative period. Read More

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December 2018

Cell Segmentation for Image Cytometry: Advances, Insufficiencies, and Challenges.

Authors:
Zhenzhou Wang

Cytometry A 2018 Dec 14. Epub 2018 Dec 14.

College of electrical and electronic engineering, Shandong University of Technology, 255000, Zibo City, Shandong Province, China.

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December 2018

Single Slide Assessment - A highly effective cytological ROSE technique for EBUS and EUS guided FNA.

Cytopathology 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Molecular Pathology, Royal Cornwall Hospital, Truro, Cornwall, UK.

No standardised, comprehensive approach to Rapid On-Site Evaluation (ROSE) of cytology samples currently exists. Recent meta-analysis indicates variation in the effectiveness of ROSE [1], however, reviews commonly omit the details of how ROSE is conducted. This review demonstrates the clinical effectiveness of Single Slide Assessment (SSA) for ROSE of cytology samples, providing a highly effective, standardised methodology, maximising cell yield and the diagnostic potential of samples obtained via Endobronchial or Endoscopic ultrasound (EBUS/EUS). Read More

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December 2018

Getting TANned: How the tumor microenvironment drives neutrophil recruitment.

J Leukoc Biol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.

The directed migration of neutrophils to sites of injury or infection is mediated by complex networks of chemoattractant-receptor signaling cascades. The recent appreciation of neutrophils as active participants in tumor progression and metastasis has drawn attention to a number of chemokine-receptor systems that may drive their recruitment to tumors. However, the dynamic nature of the tumor microenvironment (TME) along with the phenotypic diversity among tumor-associated neutrophils (TANs) call for a more comprehensive approach to understand neutrophil trafficking to tumors. Read More

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December 2018

Fused Aromatic Network Structures as a Platform for Efficient Electrocatalysis.

Adv Mater 2018 Dec 14:e1805062. Epub 2018 Dec 14.

School of Energy and Chemical Engineering, Center for Dimension-Controllable Organic Frameworks, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST, Ulsan, 44919, South Korea.

Fused aromatic network (FAN) structures are a category of ordered porous polymers that permit the specific fusion of building blocks into extended porous network structures with designed skeletons and pores. One significant feature of FANs is that their structures can be tailorable with fused aromatic rings without rotatable single-bond connectivity. As a result, the geometry and space orientation of the building blocks are easily incorporated to guide the topological expansion of the architectural periodicity. Read More

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December 2018
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Models and machines: How deep learning will take clinical pharmacology to the next level.

CPT Pharmacometrics Syst Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Roche Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Switzerland.

Recent advances in machine learning (ML) have led to enthusiasm about its use throughout the biopharmaceutical industry. ML methods can be applied to a wide range of problems and have the potential to revolutionize aspects of drug development. The incorporation of ML in modeling and simulation (M+S) has been eagerly anticipated and in this perspective we highlight examples where ML and M+S approaches can be integrated as complementary parts of a clinical pharmacology workflow. Read More

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December 2018

Beyond the Message: Advantages of Snapshot Proteomics with Single-Cell Mass Cytometry in Solid Tumors.

FEBS J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.

Single-cell technologies that can quantify features of individual cells within a tumor are critical for treatment strategies aiming to target cancer cells while sparing or activating beneficial cells. Given that key players in protein networks are often the primary targets of precision oncology strategies, it is imperative to transcend the nucleic acid message and read cellular actions in human solid tumors. Here, we review the advantages of single-cell mass cytometry. Read More

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December 2018

Understanding others: emotion recognition abilities in humans and other animals.

Genes Brain Behav 2018 Dec 13:e12544. Epub 2018 Dec 13.

Genetics of Cognition laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy.

Emotion recognition represents the ability to encode an ensemble of sensory stimuli providing information about the emotional state of another individual. This ability is not unique to humans. An increasing number of studies suggests that many aspects of higher order social functions, including emotion recognition, might be present in species ranging from primates to rodents, indicating a conserved role of these abilities in social animals. Read More

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December 2018