223,337 results match your criteria Advances in Nursing Science ANS[Journal]


Xenotransplantation: Progress Along Paths Uncertain from Models to Application.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Translational Medicine and The Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

For more than a century, transplantation of tissues and organs from animals into man, xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest in xenotransplantation was fueled especially by successful application of allotransplantation, that is, transplantation of human tissue and organs, as a treatment for a variety of diseases, especially organ failure because scarcity of human tissues limited allotransplantation to a fraction of those who could benefit. In principle, use of animals such as pigs as a source of transplants would allow transplantation to exert a vastly greater impact than allotransplantation on medicine and public health. Read More

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December 2018
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Hypertension in chronic kidney disease: Nephrology Dialysis Transplantation notable 2017 advances.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.

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December 2018

CASMAP: Detection of statistically significant combinations of SNPs in association mapping.

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Department of Biosystems Science and Engineering, ETH Zurich, Basel, 4058, Switzerland SIB Swiss Institute of Bioinformatics.

Summary: Combinatorial association mapping aims to assess the statistical association of higher-order interactions between genetic markers with a phenotype of interest. This paper presents CASMAP, a software package that leverages recent advances in significant pattern mining to overcome the statistical and computational challenges that have hindered combinatorial association mapping. CASMAP can be used to perform region-based association studies and to detect higher-order epistatic interactions of genetic variants. Read More

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December 2018

The "Difficult" Colorectal Polyps and Adenomas: Practical Aspects.

Dig Dis 2018 Dec 12:1-6. Epub 2018 Dec 12.

Background: Colonoscopy is the gold standard for adenoma detection. All endoscopists who perform colonoscopy must by mandate be skilled to perform polypectomy. However, there are significant differences between endoscopists in terms of the polyp detection rate and in the effectiveness of polypectomy. Read More

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December 2018
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Perspectives on the Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Biomedical Research.

Stem Cell Reports 2018 Dec;11(6):1306-1311

Department of Anatomy and Embryology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address:

Cardiovascular disease is still a major cause of ill-health and mortality, heart failure and arrhythmia being among the causes of sudden cardiac death. There are few drugs available for treatment or prevention and it remains difficult to predict who will develop these conditions, even when disease-causing mutations or associated gene variants are identified in individuals or families. This is in part because widely used rodent models may not fully capture the physiology of the human heart. Read More

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December 2018

[Recent advances in pediatric non-Hodgkin lymphoma. Report on a retrospective single-center cohort and review of the literature].

Magy Onkol 2018 Dec 15;62(4):204-213. Epub 2018 Oct 15.

Gyermekgyógyászati Intézet, Gyermekhematológiai-onkológiai nem önálló Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar, Debrecen, Hungary.

Classification, staging and treatment response criteria of pediatric NHL have been revised. Long-term survival reaches ~90% at the expense of severe acute toxicities. The outcome of refractory and relapsed cases is poor. Read More

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December 2018

Up-to-date vaccine delivery systems: robust immunity elicited by multifarious nanomaterials upon administration through diverse routes.

Biomater Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. and City University of Hong Kong Shenzhen Research Institute, Shenzhen 518075, P. R. China.

In this review, we summarize the recent design strategies (2015-present) of nanomaterial-based vaccine delivery systems via multiple routes to induce robust protective immunity. The selected topics are focused on the novel design strategies of nanomaterial carriers for vaccine delivery. Inspired by recent advances, we also briefly introduce the emerging administration routes that may give rise to synergistic immune effects with advanced delivery systems. Read More

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December 2018

Cardiac Vagus and Exercise.

Physiology (Bethesda) 2019 Jan;34(1):71-80

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom.

Lower resting heart rate and high autonomic vagal activity are strongly associated with superior exercise capacity, maintenance of which is essential for general well-being and healthy aging. Recent evidence obtained in experimental studies using the latest advances in molecular neuroscience, combined with human exercise physiology, physiological modeling, and genomic data suggest that the strength of cardiac vagal activity causally determines our ability to exercise. Read More

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January 2019

Parkinson's disease: a short story of 200 years.

Histol Histopathol 2018 Dec 12:18073. Epub 2018 Dec 12.

Clinical and Experimental Neuroscience Group (NiCE-IMIB), Department of Human Anatomy and Psychobiology, Institute for Aging Research, School of Medicine, University of Murcia, Murcia, Spain.

After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and incidental neurodegenerative disorder, affecting more than 2% of the population older than 65 years old. Since it was first described 200 years ago by Dr James Parkinson, great steps have been made in the understanding of the pathology. However, the cause(s) that initiates and perpetuates the neurodegenerative process is (are) still not clear. Read More

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December 2018

RECOMMENDATIONS OF THE BRAZILIAN SOCIETY OF HEPATOLOGY FOR THE MANAGEMENT OF ACUTE KIDNEY INJURY IN PATIENTS WITH CIRRHOSIS.

Arq Gastroenterol 2018 Jul-Sep;55(3):314-320

Hospital Português, Unidade de Gastroenterologia e Hepatologia, Salvador, BA, Brasil.

Acute kidney injury is a common complication of cirrhosis, occurring in up to 20% of patients hospitalized with cirrhosis. This field is rapidly changing, with significant advances in classification, biomarkers and therapy over the last few years. On the behalf of the Brazilian Society of Hepatology, a panel of experts in Hepatology and Nephrology reviewed published evidence to integrate findings and develop the recommendations presented in this manuscript. Read More

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HEPATITIS B AND C IN PREGNANT WOMEN ATTENDED BY A PRENATAL PROGRAM IN AN UNIVERSITARY HOSPITAL IN RIO DE JANEIRO, BRAZIL: RETROSPECTIVE STUDY OF SEROPREVALENCE SCREENING.

Arq Gastroenterol 2018 Jul-Sep;55(3):267-273

Universidade Federal Fluminense, Faculdade de Medicina, Departamento de Medicina Interna, Rio de Janeiro, RJ, Brasil.

Background: Hepatitis B and C are diseases with high morbimortality and constitute a global public health problem. In Brazil, the prevalence is not homogeneous, oscillating among different regions, but it is estimated that currently about 1% of the population present chronic disease related to the B virus and that there are 1.5 million infected with the C virus. Read More

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ADVANCES IN THERAPEUTIC ENDOSCOPY.

Arq Gastroenterol 2018 Jul-Sep;55(3):201

Endovitta Instituto, São Paulo, SP, Brasil.

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December 2018

Education-service integration in the context of Brazilian medical schools: an integrative review.

Cien Saude Colet 2018 Dec;23(12):4241-4248

Escola Paulista de Medicina, Universidade Federal de São Paulo. Santos SP Brasil.

This paper aimed to characterize the historical trajectory, including the advances and challenges, of the teaching-service integration in the medical training process. In this context, through scientific studies indexed in databases, a critical review of the literature was performed from the search for works of reference until the present moment. Most of the works consulted were reference material on the topic published in scientific journals and indexed in the databases of the Virtual Health Library. Read More

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December 2018

Multitarget therapeutic strategies for Alzheimer's disease.

Neural Regen Res 2019 Mar;14(3):437-440

Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Department of Chemistry, University of Iowa, Iowa City, IA, USA.

Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. The major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. Read More

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The pig as a preclinical traumatic brain injury model: current models, functional outcome measures, and translational detection strategies.

Neural Regen Res 2019 Mar;14(3):413-424

Regenerative Bioscience Center; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.

Traumatic brain injury (TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. Read More

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Moving from the present to the future of Postural Tachycardia Syndrome - What we need.

Auton Neurosci 2018 Dec 4;215:126-128. Epub 2018 Jul 4.

Autonomic Dysfunction Center, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.

Our understanding about Postural Tachycardia Syndrome (POTS) has advanced significantly over the last 25 years. Despite the significant advances that have been made in defining the syndrome and finding some treatments for our patients, there is much work to be done to significantly improve our understanding of the disorder and improve therapeutics. In this article, 5 NEEDS are identified that will be required over the next several years if we want future care to move beyond where we are in the present. Read More

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December 2018

Temporal Trends in Gender-Related Differences and Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the Israeli Transcatheter Aortic Valve Implantation Multicenter Registry).

Am J Cardiol 2019 Jan 3;123(1):108-115. Epub 2018 Oct 3.

Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

We evaluated temporal trends in gender-related differences in patients who underwent transcatheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis from a multicenter TAVI registry during the years 2008 to 2016. Our final cohort included 1,159 males and 1,370 females, with a median follow-up of 2.3 (IQR 1. Read More

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January 2019

Advances in food allergy in 2017.

J Allergy Clin Immunol 2018 Dec 25;142(6):1719-1729. Epub 2018 Oct 25.

Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia.

This review highlights research and policy advances in food allergy that were published in 2017 in the Journal and beyond. In 2017, many important studies on the treatment of food allergy were published, bringing us ever closer to a standardized treatment for food allergy. Other important advancements included research into other management strategies, including thresholds for avoidance, management of food allergies in schools, and development of new guidelines for prevention of food allergy. Read More

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December 2018
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Therapeutic Trends in Pancreatic ductal adenocarcinoma (PDAC).

Expert Opin Investig Drugs 2018 Dec 12. Epub 2018 Dec 12.

d Early Phase Therapeutics Program , University of Arizona Cancer Center , Tucson AZ , USA .

Introduction: Prognosis remains dismal for pancreatic ductal adenocarcinoma (PDAC). Genomics and proteomics has depicted heterogeneity in PDAC. Collectively, this information could be useful in improving diagnosis, prognosis, modalities of therapy, treatment responses, deciphering drug resistance and new drug development. Read More

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December 2018

Mapping and Quantification of tRNA 2'-O-Methylation by RiboMethSeq.

Methods Mol Biol 2019 ;1870:273-295

Next-Generation Sequencing Core Facility, UMS2008 IBSlor, CNRS-UL-INSERM, BioPole Lorraine University, Nancy, France.

Current development of epitranscriptomics field requires efficient experimental protocols for precise mapping and quantification of various modified nucleotides in RNA. Despite important advances in the field during the last 10 years, this task is still extremely laborious and time-consuming, even when high-throughput analytical approaches are employed. Moreover, only a very limited subset of RNA modifications can be detected and only rarely be quantified by these powerful techniques. Read More

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January 2019

High-Resolution Mapping of N -Methyladenosine Using mA Crosslinking Immunoprecipitation Sequencing (mA-CLIP-Seq).

Methods Mol Biol 2019 ;1870:69-79

Department of Chemistry and Institute for Biophysical Dynamics; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA.

N -Methyladenosine, an abundant chemical modification in mRNA, plays crucial roles in regulating gene expression and biological processes. Research on mA and its functions has progressed rapidly in the past few years, aided substantially by advances in high-throughput sequencing-based methods to profile mA along the transcriptome. We present here a protocol for mA crosslinking immunoprecipitation sequencing (mA-CLIP-seq), which profiles mA on mRNA at high resolution from as little as 1 μg of poly(A)-selected mRNA. Read More

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January 2019

HAMR: High-Throughput Annotation of Modified Ribonucleotides.

Methods Mol Biol 2019 ;1870:51-67

Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.

Ribonucleotides can be decorated with over 100 types of covalent chemical modifications. These modifications change the structure, function, and catalytic activity of RNAs, forming a layer of posttranscriptional regulation termed the epitranscriptome. Recent advances in high-throughput mapping have demonstrated these modifications are abundant and mark nearly all classes of RNAs, including messenger RNAs. Read More

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January 2019

Update on Immunotherapy in AML and MDS: Monoclonal Antibodies and Checkpoint Inhibitors Paving the Road for Clinical Practice.

Adv Exp Med Biol 2018 ;995:97-116

Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.

In the past few years, our improved understanding of the pathogenesis of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) has led to remarkable advances in the development of novel therapeutic approaches for these diseases. This chapter summarizes the available clinical data with immune-based therapeutic modalities in AML and MDS, focusing on monoclonal antibodies, T cell engager antibodies, chimeric antigen receptor (CAR)-T cells, and checkpoint blockade via blockade of PD-1/PD-L1 or CTLA4. Numerous clinical trials are currently ongoing in patients with AML and MDS, both in the frontline and relapsed refractory setting. Read More

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January 2018

Immunotherapy for Melanoma.

Adv Exp Med Biol 2018 ;995:43-63

, Baltimore, MD, USA.

While melanoma is less common than some other skin cancers, it is responsible for nearly 10,000 deaths in the USA each year alone. For many decades, very limited treatment options were available for patients with metastatic melanoma. However, recent breakthroughs have brought new hopes for patients and providers. Read More

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January 2018
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Cancer Immunotherapy: The Dawn of Antibody Cocktails.

Methods Mol Biol 2019 ;1904:11-51

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

Since the approval of the first monoclonal antibody (mAb), rituximab, for hematological malignancies, almost 30 additional mAbs have been approved in oncology. Despite remarkable advances, relatively weak responses and resistance to antibody monotherapy remain major open issue. Overcoming resistance might require combinations of drugs blocking both the major target and the emerging secondary target. Read More

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January 2019

New therapies for anaplastic thyroid cancer.

Drugs Today (Barc) 2018 Nov;54(11):695-704

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Anaplastic thyroid cancer is a rare but extremely aggressive type of thyroid cancer. Treatment typically consists of surgery, external beam radiotherapy and cytotoxic chemotherapy. However, available literature suggests only modest survival benefit for cytotoxic chemotherapy. Read More

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November 2018

Utility of "liquid biopsy" using pancreatic juice for early detection of pancreatic cancer.

Endosc Int Open 2018 Dec 10;6(12):E1454-E1461. Epub 2018 Dec 10.

Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.

 Despite advances in the diagnosis of pancreatic ductal adenocarcinoma (PDA), histological evaluation of small and poorly defined masses in the pancreas is uncomfortable and unsafe.  We herein report a case of early stage PDA, in which multiple KRAS mutations were detected in the pancreatic juice preoperatively. A small hypoechoic area adjacent to the portal vein was detected through endoscopic ultrasound in the pancreatic body. Read More

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December 2018

Genetically Modified Labeling Policies: Moving Forward or Backward?

Front Bioeng Biotechnol 2018 27;6:181. Epub 2018 Nov 27.

Biotechnology Group, Federal University of Espírito Santo, Vitória, Brazil.

One of the priorities to address food security is to increase the access of farmers to biotechnology, through the application of scientific advances, such as genetically modified organisms and food (GMF). However, the spread of (mis)information about their safety strengthens the clamor for mandatory GMF labeling. This paper provides an overview of food labeling policies, considering the principles suggested by the Codex Alimentarius Commission, and analyzes the consequences for the world food security of the Brazilian labeling policies compared to developed countries. Read More

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November 2018

Engineered Nanostructured Materials for Ofloxacin Delivery.

Front Chem 2018 27;6:554. Epub 2018 Nov 27.

BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University of Lisbon, Almada, Portugal.

Antibiotic resistance is emerging as a growing worldwide problem and finding solutions to this issue is becoming a new challenge for scientists. As the development of new drugs slowed down, advances in nanotechnology offer great opportunities, with the possibility of designing new systems for carrying, delivery and administration of drugs already in use. Engineered combinations of the synthetic, broad-spectrum antibiotic ofloxacin, rarely studied in this field, with different types of silver, mesoporous silica-based and Pluronic/silica-based nanoparticles have been explored. Read More

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November 2018

Rett Syndrome in Males: A Case Report and Review of Literature.

Cureus 2018 Oct 4;10(10):e3414. Epub 2018 Oct 4.

Neurology, University of Missouri, Columbia, USA.

Rett syndrome (RTT) is a neurodevelopmental disorder in which a period of normal development is followed by regression of previously acquired skills. RTT was originally thought to be present exclusively in females. However, advances in genetic testing and phenotypic identification revealed that it is not a female-only disorder as cases of males with similar phenotype were reported. Read More

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October 2018

Screening of Cervical Cancer with Self-Collected Cervical Samples and Next-Generation Sequencing.

Dis Markers 2018 14;2018:4826547. Epub 2018 Nov 14.

Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Cervical cancer is the second leading cause of death in female genital malignancies. Persistent infection with high-risk HPV is closely related to cervical intraepithelial neoplasia (CIN). Wide-scale HPV screening has already been implemented in developed countries. Read More

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November 2018

Revisiting the Concept of Targeting NFAT to Control T Cell Immunity and Autoimmune Diseases.

Front Immunol 2018 27;9:2747. Epub 2018 Nov 27.

Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, South Korea.

The nuclear factor of activated T cells (NFAT) family of transcription factors, which includes NFAT1, NFAT2, and NFAT4, are well-known to play important roles in T cell activation. Most of NFAT proteins are controlled by calcium influx upon T cell receptor and costimulatory signaling results increase of IL-2 and IL-2 receptor. NFAT3 however is not shown to be expressed in T cells and NFAT5 has not much highlighted in T cell functions yet. Read More

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November 2018

Origin, Differentiation, and Function of Intestinal Macrophages.

Front Immunol 2018 27;9:2733. Epub 2018 Nov 27.

Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.

Macrophages are increasingly recognized as essential players in the maintenance of intestinal homeostasis and as key sentinels of the intestinal immune system. However, somewhat paradoxically, they are also implicated in chronic pathologies of the gastrointestinal tract, such as inflammatory bowel disease (IBD) and are therefore considered potential targets for novel therapies. In this review, we will discuss recent advances in our understanding of intestinal macrophage heterogeneity, their ontogeny and the potential factors that regulate their origin. Read More

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November 2018

Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging.

Front Endocrinol (Lausanne) 2018 27;9:515. Epub 2018 Nov 27.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare commonly benign neuroendocrine tumors that share pathology features and clinical behavior in many cases. While PCCs are chromaffin-derived tumors that arise within the adrenal medulla, PGLs are neural-crest-derived tumors that originate at the extraadrenal paraganglia. Pheochromocytoma-paraganglioma (PPGL) syndromes are rapidly evolving entities in endocrinology and oncology. Read More

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November 2018

Exploring the Effectiveness of Immersive Video for Training Decision-Making Capability in Elite, Youth Basketball Players.

Front Psychol 2018 27;9:2315. Epub 2018 Nov 27.

Movement Science, Australian Institute of Sport, Canberra, ACT, Australia.

Decision-making is an essential capability for success in team sport athletes. Good decision-making is underpinned by perceptual-cognitive skills that allow athletes to assess the environment and choose the correct choice from a number of alternatives. Previous research has demonstrated that decision-making can be trained "off-line" by exposing athletes to gameplay scenarios and having them make decisions based on the information presented to them. Read More

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November 2018

Pathophysiology of Subjective Tinnitus: Triggers and Maintenance.

Front Neurosci 2018 27;12:866. Epub 2018 Nov 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Tinnitus is the conscious perception of a sound without a corresponding external acoustic stimulus, usually described as a perception. One of the major challenges for tinnitus research is to understand the pathophysiological mechanisms triggering and maintaining the symptoms, especially for subjective chronic tinnitus. Our objective was to synthesize the published literature in order to provide a comprehensive update on theoretical and experimental advances and to identify further research and clinical directions. Read More

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November 2018

Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma.

Cancer Manag Res 2018 21;10:6097-6108. Epub 2018 Nov 21.

Department of Respiratory Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China,

Background: Lung cancer is one of the most common malignant tumors. Despite advances in lung cancer therapies, prognosis of non-small-cell lung cancer is still unfavorable. The aim of this study was to identify the prognostic value of key genes in lung tumorigenesis. Read More

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November 2018

Hypoxia and hyperbaric oxygen therapy: a review.

Authors:
Ryan Choudhury

Int J Gen Med 2018 20;11:431-442. Epub 2018 Nov 20.

Department of Internal Medicine, Graduate Medical Education, St Vincent Charity Medical Center, Cleveland, OH, USA,

Hypoxia causes a cascade of activity from the level of the individual down to the regulation and function of the cell nucleus. Prolonged periods of low oxygen tension are a core feature of several disease states. Advances in the study of molecular biology have begun to bridge the gap between the cellular response to hypoxia and physiology. Read More

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November 2018

Novel application of trimethyl chitosan as an adjuvant in vaccine delivery.

Int J Nanomedicine 2018 23;13:7959-7970. Epub 2018 Nov 23.

Molecular Biology and Genetic Engineering Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India,

The application of natural carbohydrate polysaccharides for antigen delivery and its adjuvanation potential has garnered interest in the scientific community in the recent years. These biomaterials are considered favorable candidates for adjuvant development due to their desirable properties like enormous bioavailability, non-toxicity, biodegradability, stability, affordability, and immunostimulating ability. Chitosan is the one such extensively studied natural polymer which has been appreciated for its excellent applications in pharmaceuticals. Read More

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November 2018

A Zr-labeled lipoplex nanosystem for image-guided gene delivery: design, evaluation of stability and in vivo behavior.

Int J Nanomedicine 2018 21;13:7801-7818. Epub 2018 Nov 21.

Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada,

Background: With the advances in radiopharmaceutical research, the development of image-guided therapy has become a major interest. While the development of theranostic nanotherapeutics is frequently associated with cancer chemotherapy, phototherapy and radiotherapy, there is little information available on the in vivo monitoring of gene delivery systems and the application of image-guided approach in gene therapy. The goal of this work was to determine the in vivo behavior of DNA delivery nanosystems - based on cationic gemini surfactants - designed for image-guided gene therapy. Read More

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November 2018

Recent advances in ultrasound-based transdermal drug delivery.

Int J Nanomedicine 2018 20;13:7749-7763. Epub 2018 Nov 20.

School of Chemistry, Monash University, Clayton, VIC 3800, Australia,

The transdermal transport of pharmaceuticals possesses various advantageous properties over conventional drug administration techniques such as oral delivery and hypodermic injections. However, the stratum corneum persists as the main barrier, which impedes percutaneous transport. The ultrasound-based transdermal delivery of therapeutics is one of the techniques that are being investigated to overcome this obstacle. Read More

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November 2018

New therapeutic strategies in systemic lupus erythematosus management.

Nat Rev Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Unit of Rheumatology, Department of Medicine, University of Padova, Padova, Italy.

The current treatment approach for systemic lupus erythematosus (SLE), as outlined in the recommendations by international medical associations including EULAR and the ACR, is mostly eminence-based rather than evidence-based. However, knowledge on SLE is growing quickly, and such new advances need to be translated into clinical practice. Questions remain regarding the choice and timing of drug administration and tapering until withdrawal, which both can affect the balance between the control of disease activity and damage to organs triggered by long-standing and/or disproportionate immunosuppression. Read More

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December 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nat Commun 2018 12 11;9(1):5280. Epub 2018 Dec 11.

Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

Acute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major causes of death in children with cancer and for children with AML relapse is the most common cause of death. Here, by modelling AML in vivo we demonstrate that AML is discriminated by the age of the cell of origin. Read More

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December 2018

Application of atomic force microscopy in cancer research.

J Nanobiotechnology 2018 Dec 11;16(1):102. Epub 2018 Dec 11.

The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and molecules. Recent advances have enabled its application in cancer research and diagnosis. The physicochemical properties of live cells undergo changes when their physiological conditions are altered. Read More

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December 2018

Barriers and facilitators to hepatitis C (HCV) screening and treatment-a description of prisoners' perspective.

Harm Reduct J 2018 Dec 11;15(1):62. Epub 2018 Dec 11.

School of Medicine University College, Dublin, Ireland.

Background: Hepatitis C virus (HCV) infection is a global epidemic with an estimated 71 million people infected worldwide. People who inject drugs (PWID) are overrepresented in prison populations globally and have higher levels of HCV infection than the general population. Despite increased access to primary health care while in prison, many HCV infected prisoners do not engage with screening or treatment. Read More

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December 2018

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke.

J Neuroinflammation 2018 Dec 11;15(1):339. Epub 2018 Dec 11.

Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, China.

Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx. Read More

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December 2018

Specialized pediatric palliative care services for children dying from cancer: A repeated cohort study on the developments of symptom management and quality of care over a 10-year period.

Palliat Med 2018 Dec 12:269216318818022. Epub 2018 Dec 12.

1 Paediatric Palliative Care Centre and German Paediatric Pain Centre, Children's and Adolescents' Hospital, Datteln, Germany.

Background:: About one quarter of children affected with cancer die. For children and their families, the end-of-life period is highly distressing.

Aim:: This study focused on how end-of-life care in pediatric cancer patients changed over a period of 10 years and if changes in pediatric palliative care structures were associated with quality of care. Read More

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December 2018

A Rigorous Free Energy Perturbation Approach to Estimating Relative Binding Affinities between Ligands with Multiple Protonation and Tautomeric States.

J Chem Theory Comput 2018 Dec 11. Epub 2018 Dec 11.

Accurate prediction of ligand binding affinities is of key importance in lead optimization and a central task in computational medicinal chemistry. Over the years, advances in both computer hardware and computational methodologies have established free energy perturbation (FEP) methods as among the most reliable and rigorous approaches to compute protein-ligand binding free energies. However, accurate description of ionization and tautomerism of ligands is still a major challenge in structure-based prediction of binding affinities. Read More

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December 2018

Perforation of mitral-aortic intervalvular fibrosa secondary to bicuspid aortic valve endocarditis: Possible relation with diagnostic coronary angiography.

J Cardiol Cases 2013 Jan 5;7(1):e15-e17. Epub 2012 Oct 5.

Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey.

Infective endocarditis (IE) remains a serious and deadly disease despite recent advances in diagnosis and treatment. In all IE cases, the rate of healthcare-associated IE has been reported as 23%. Aortic valve endocarditis may extend to mitral-aortic intervalvular fibrosa (MAIVF), which may cause pseudoaneurysm formation and subsequent perforation. Read More

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January 2013

Heterometallic grids: synthetic strategies and recent advances.

Dalton Trans 2018 Dec 7. Epub 2018 Dec 7.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. and University of Science and Technology of China, Hefei, 230026, P. R. China.

Supramolecular metallogrid complexes are metalloclusters involving metal ions in planar array arrangements and organic ligands in perpendicular arrangements at each corner of the metal sites. Such essentially metal ion arrays have attracted great attention in the last three decades owing to their variety of interesting optical, electronic and magnetic properties. Among them, metallogrids containing more than one type of metal, that is heterometallic grids, are rare but have more potential to engineer a higher level functionality into one molecule. Read More

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December 2018