299,305 results match your criteria Advances in Meteorology[Journal]

Developing and Implementing Predictive Models in a Learning Healthcare System: Traditional and Artificial Intelligence Approaches in the Veterans Health Administration.

Annu Rev Biomed Data Sci 2022 May 24. Epub 2022 May 24.

Office of Discovery, Education and Affiliate Networks, Department of Veterans Affairs, Washington, DC, USA.

Predicting clinical risk is an important part of healthcare and can inform decisions about treatments, preventive interventions, and provision of extra services. The field of predictive models has been revolutionized over the past two decades by electronic health record data; the ability to link such data with other demographic, socioeconomic, and geographic information; the availability of high-capacity computing; and new machine learning and artificial intelligence methods for extracting insights from complex datasets. These advances have produced a new generation of computerized predictive models, but debate continues about their development, reporting, validation, evaluation, and implementation. Read More

View Article and Full-Text PDF

Discovering Biological Conflict Systems Through Genome Analysis: Evolutionary Principles and Biochemical Novelty.

Annu Rev Biomed Data Sci 2022 May 24. Epub 2022 May 24.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA; email:

Biological replicators, from genes within a genome to whole organisms, are locked in conflicts. Comparative genomics has revealed a staggering diversity of molecular armaments and mechanisms regulating their deployment, collectively termed biological conflict systems. These encompass toxins used in inter- and intraspecific interactions, self/nonself discrimination, antiviral immune mechanisms, and counter-host effectors deployed by viruses and intragenomic selfish elements. Read More

View Article and Full-Text PDF

Factors associated with non-presentation in a multidisciplinary team meeting for colon cancer: a matched retrospective cohort study in a French area.

Clin Res Hepatol Gastroenterol 2022 May 21:101950. Epub 2022 May 21.

Gastroenterology department, University hospital of Brest, 29200 Brest, France. Electronic address:

Background: Survival of patients with colon cancer has increased in recent years due to advances in treatment and the implementation of multidisciplinary team meetings (MDTm). However, the organization of MDTm can be improved. The objectives of this work were to characterize patients with colon cancer who were not presented in MDTm and to analyse the reasons for their non-presentation. Read More

View Article and Full-Text PDF

Top 25 cited articles on Covid-19 and IBD: A bibliometric analysis.

Clin Res Hepatol Gastroenterol 2022 May 21:101959. Epub 2022 May 21.

Faculty of Medicine, Tel-Aviv University, Israel; Sami Sagol AI Hub, ARC, Sheba Medical Center, Israel.

Objectives: The use of citation analysis to identify the most cited covid-19 and inflammatory bowel disease (IBD) manuscripts to provide an insight into the advances and knowledge accumulated regarding the pandemic in this subgroup of patients.

Methods: We've used a public application programming interface (API) U.S. Read More

View Article and Full-Text PDF

Mycobacterium smegmatis acyltransferase: The big new player in biocatalysis.

Biotechnol Adv 2022 May 21:107985. Epub 2022 May 21.

Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy. Electronic address:

After several decades during which proteases and after lipases took the biotransformation world scene as the predominant biocatalysts, a new, promising enzyme was discovered and characterized. The acyltransferase from Mycobacterium smegmatis (MsAcT) has in fact an extraordinary activity for a wide array of reactions, such as trans-esterification, amidation, trans-amidation and perhydrolysis, both in water and solvent media, giving rise to a series of interesting compounds including APIs (i.e. Read More

View Article and Full-Text PDF

Advances in synthetic biology tools paving the way for the biomanufacturing of unusual fatty acids using the Yarrowia lipolytica chassis.

Biotechnol Adv 2022 May 21:107984. Epub 2022 May 21.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, People's Republic of China. Electronic address:

Unusual fatty acids with special carbon chain length or functional groups have been extensively used in the chemical, material, nutraceutical, and pharmaceutical industries. The traditional sources of these valuable fatty acids mainly include animal or plant extraction and chemical synthesis, which are unsustainable and may cause considerable environmental issues. The advancement of synthetic biology tools has facilitated the microbial production of lipids enriched in these fatty acids. Read More

View Article and Full-Text PDF

Understanding of the various aspects of gene regulatory networks related to crop improvement.

Gene 2022 May 21:146556. Epub 2022 May 21.

Department of Genetics, University of Georgia, GA 30606, United States.

The hierarchical relationship between transcription factors, associated proteins, and their target genes is defined by a gene regulatory network (GRN). GRNs allow us to understand how the genotype and environment of a plant are incorporated to control the downstream physiological responses. During plant growth or environmental acclimatization, GRNs are diverse and can be differently regulated across tissue types and organs. Read More

View Article and Full-Text PDF

Volatile organic compounds in aquatic ecosystems - Detection, origin, significance and applications.

Sci Total Environ 2022 May 21:156155. Epub 2022 May 21.

Molecular Genetics, Institute of Plant Biotechnology, Universdiad Politécnica de Cartagena, Campus Muralla del Mar. 30202, Cartagena, Murcia, Spain. Electronic address:

Volatile organic compounds (VOCs) include a broad range of compounds. Their production influences a large number of processes, having direct and secondary effects on different fields, such as climate change, economy and ecology. Although our planet is primarily covered with water (~70% of the globe surface), the information on aquatic VOCs, compared to the data available for the terrestrial environments, is still limited. Read More

View Article and Full-Text PDF

Recent advances in soil microbial fuel cells based self-powered biosensor.

Chemosphere 2022 May 21:135036. Epub 2022 May 21.

Biofuels Institute, School of Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu Province, China. Electronic address:

The soil microbial fuel cell (SMFC) is a new device that was originally designed to generate electricity from organic matter in soil using microorganisms. Currently, SMFC based biosensors are emerging as a new and promising research direction for real-time and rapid monitoring of soil quality or soil pollution. Compared to conventional biosensors, SMFC based biosensors exhibit advantages such as low-cost, simple design, in-situ, and long-term self-powering monitoring, which makes it become attractive devices for in-situ long-term soil quality or soil pollution monitoring. Read More

View Article and Full-Text PDF

Advances in the study of spheroids as versatile models to evaluate biological interactions of inorganic nanoparticles.

Life Sci 2022 May 21:120657. Epub 2022 May 21.

Departamento de Biofísica e Radiobiologia, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brazil. Electronic address:

Spheroids are in vitro three-dimensional multicellular microstructures able to mimic the biological microenvironment, including the complexity of tumor architecture. Therefore, results closer to those expected for in vivo organisms can be reached using spheroids compared to the cell culture monolayer model. Inorganic nanoparticles (NPs) have also been played relevant roles in the comprehension of biological processes. Read More

View Article and Full-Text PDF

The Efficacy of Alternate Systemic Intravenous Chemotherapy and Intra-Arterial Chemotherapy Approach for Eye Globe Salvage in Retinoblastoma.

Cancer Res Treat 2022 May 24. Epub 2022 May 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.

Purpose: The advances in the treatment of retinoblastoma have enabled salvaging the globe in advanced stages with intra-arterial chemotherapy (IAC). We developed a strategy of alternate application of systemic intravenous chemotherapy (IVC) and IAC (referred to as alternate systemic IVC and IAC; ASIAC) to reduce central nervous metastases during IAC and examined its efficacy and safety in eye globe salvage in this study.

Materials And Methods: Between January 2010 and February 2021, 43 eyes of 40 patients received ASIAC treatment for retinoblastoma at the Yonsei Cancer Center, Yonsei University Health System. Read More

View Article and Full-Text PDF

Advances in heterostructured scintillators: toward a new generation of detectors for TOF-PET.

Phys Med Biol 2022 May 24. Epub 2022 May 24.

, CERN, Espl. des Particules 1, Geneve, 1211, SWITZERLAND.

. TOF-PET would highly benefit from a coincidence time resolution (CTR) below 100 ps: improvement in image quality and patient workflow, and reduction of delivered dose are among them. This achievement proved to be quite challenging, and many approaches have been proposed and are being investigated for this scope. Read More

View Article and Full-Text PDF

Ultrasonographic Evaluation of Peripheral Nerves: Technical Considerations.

Semin Musculoskelet Radiol 2022 Apr 24;26(2):105-113. Epub 2022 May 24.

Section of Musculoskeletal Radiology, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.

Advances in ultrasonographic (US) technology featuring high-resolution transducers have revolutionized US over recent years as a modality increasingly used in the evaluation of musculoskeletal structures and peripheral nerves. A wide variety of nerve pathologies can be detected, such as neoplastic and tumorlike lesions, entrapment syndromes, posttraumatic injuries, and inflammatory conditions. US can serve as an imaging tool for guiding percutaneous treatments, such as injection therapies or hydrodissection, and assist with perioperative nerve marking and visualization of peripheral nerves in the operating room. Read More

View Article and Full-Text PDF

Engineering microbial consortia with rationally designed cellular interactions.

Curr Opin Biotechnol 2022 May 21;76:102730. Epub 2022 May 21.

Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA; Department of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA; Center for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA; National Center for Supercomputing Applications, Urbana, IL, USA. Electronic address:

Synthetic microbial consortia represent a frontier of synthetic biology that promises versatile engineering of cellular functions. They are primarily developed through the design and construction of cellular interactions that coordinate individual dynamics and generate collective behaviors. Here we review recent advances in the engineering of synthetic communities through cellular-interaction programming. Read More

View Article and Full-Text PDF

Preclinical detection of lysophosphatidic acid: A new window for ovarian cancer diagnostics.

Talanta 2022 May 17;247:123561. Epub 2022 May 17.

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China. Electronic address:

Ovarian cancer, a highly metastatic disease characterized by widespread peritoneal and ascites dissemination, is the leading cause of death from gynecological malignancies and poses a serious threat to women's lives. Biomarkers detection for the early diagnosis is crucial to ameliorate the dismal survival rate. Currently, there is much interest in lysophosphatidic acid (LPA), with evidences shown that the elevated LPA level in plasma could serve as an effective biomarker for ovarian cancer. Read More

View Article and Full-Text PDF

Cost and efficiency perspectives of ceramic membranes for water treatment.

Water Res 2022 May 17;220:118629. Epub 2022 May 17.

Institute for Sustainable Industries & Liveable Cities, Victoria University, PO Box 14428, Melbourne, Australia.

More robust ceramic membranes with tailorable structures and functions are increasingly employed for water treatment, particularly in some harsh applications for their ultra-long service lifespan due to their high mechanical, structural, chemical and thermal stability and anti-fouling properties. Decreasing cost and enhancing efficiency are two key but quite challenging application-oriented issues for broader and larger-scale engineering application of current ceramic membranes, and are required to make ceramic membranes a highly efficient and economic water treatment technique. In this review, we critically discuss these two significant concerns of both cost and efficiency for water treatment ceramic membranes, focusing on an overview of various advanced strategies and mechanism insights. Read More

View Article and Full-Text PDF

Mining cell-cell signaling in single-cell transcriptomics atlases.

Curr Opin Cell Biol 2022 May 21;76:102101. Epub 2022 May 21.

Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Electronic address:

Recent advances in single-cell RNA sequencing (scRNA-seq) techniques lead to an explosion of single-cell atlases from diverse biological contexts. The information of cell-cell signaling events, which underlie multicellular organism function, is embedded in these atlases. Here, we review current strategies of mining cell-cell signaling events from single-cell transcriptomics datasets and highlight examples where functions of predicted cell-cell signaling events from single-cell atlases are further pursued to yield new insights into biological processes. Read More

View Article and Full-Text PDF

Post-transcriptional control of T-cell development in the thymus.

Immunol Lett 2022 May 16;247:1-12. Epub 2022 May 16.

Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried, Germany; Research Unit Molecular Immune Regulation, Helmholtz Zentrum München, Munich, Germany. Electronic address:

T-cell development in the thymus is dependent on the continual colonization by bone-marrow derived progenitor cells. Once inside the thymus, progenitors undergo a series of well-defined differentiation events, including lineage commitment, somatic recombination of T-cell receptor (TCR) gene loci, and selection of clones with productively recombined yet non-autoreactive TCRs. Cell-cell interactions, cytokine signals, transcriptional as well as epigenetic programs controlling T-cell development are comparatively well-characterized. Read More

View Article and Full-Text PDF

Exploring the role of R&D collaborations and non-patent IP policies in government technology transfer performance: Evidence from U.S. federal agencies (1999-2016).

PLoS One 2022 24;17(5):e0268828. Epub 2022 May 24.

School of Business, Wake Forest University, Winston-Salem, North Carolina, United States of America.

Around the world, governments make substantial investments in public sector research and development (R&D) entities and activities to generate major scientific and technical advances that may catalyze long-term economic growth. Institutions ranging from the Chinese Academy of Sciences to the French National Centre for Scientific Research to the Helmholtz Association of German Research Centers conduct basic and applied R&D to create commercially valuable knowledge that supports the innovation goals of their respective government sponsors. Globally, the single largest public sector R&D sponsor is the U. Read More

View Article and Full-Text PDF

Feeding cats with chronic kidney disease food supplemented with betaine and prebiotics increases total body mass and reduces uremic toxins.

PLoS One 2022 24;17(5):e0268624. Epub 2022 May 24.

Pet Nutrition Center, Hill's Pet Nutrition, Topeka, Kansas, United States of America.

Cats with chronic kidney disease (CKD) have a decreased ability to maintain body weight. As CKD advances, loss of body weight contributes to morbidity and mortality. The goal of this study was to evaluate the combined effects of feeding betaine and prebiotics on body weight of both CKD and healthy cats. Read More

View Article and Full-Text PDF

Targeted therapies in non-small cell lung cancer and the potential role of AI interventions in cancer treatment.

Biotechnol Appl Biochem 2022 May 24. Epub 2022 May 24.

Department of Biotechnology, Delhi Technological University, Delhi, India.

Non-small cell lung cancer is the most prevalent lung cancer, and almost three-fourths of patients are diagnosed in the advanced stage directly. In this stage, chemotherapy gives only a 15% five-year survival rate. Since people have varied symptoms and reactions to a specific cancer type, treatment for that tumor is likely to fall short, complicating cancer therapy. Read More

View Article and Full-Text PDF

Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients With Metastatic Colorectal Cancer, 1986-2016: A Systematic Review.

JAMA Netw Open 2022 May 2;5(5):e2213588. Epub 2022 May 2.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston.

Importance: Phase 3 trials for patients with metastatic colorectal cancer (mCRC) have been conducted with varying designs and often with surrogate end points for overall survival (OS).

Objectives: To critically examine the factors associated with clinically relevant improvement in OS (defined as ≥2 months) in these trials and to evaluate their association with outcomes reflected in Surveillance, Epidemiology, and End Results (SEER) registry data.

Evidence Review: Medline, EMBASE, Cochrane, Web of Science, ClinicalTrials. Read More

View Article and Full-Text PDF

Incidence of Ischemic Stroke in Patients With Asymptomatic Severe Carotid Stenosis Without Surgical Intervention.

JAMA 2022 May;327(20):1974-1982

Division of Research, Kaiser Permanente Northern California, Oakland.

Importance: Optimal management of patients with asymptomatic severe carotid stenosis is uncertain, due to advances in medical care and a lack of contemporary data comparing medical and surgical treatment.

Objective: To estimate stroke outcomes among patients with medically treated asymptomatic severe carotid stenosis who did not undergo surgical intervention.

Design, Setting, And Participants: Retrospective cohort study that included 3737 adult participants with asymptomatic severe (70%-99%) carotid stenosis diagnosed between 2008 and 2012 and no prior intervention or ipsilateral neurologic event in the prior 6 months. Read More

View Article and Full-Text PDF

Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.

J Med Chem 2022 May 24. Epub 2022 May 24.

Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.

Major advances have recently defined functions for human mono-ADP-ribosylating PARP enzymes (mono-ARTs), also opening up potential applications for targeting them to treat diseases. Structural biology combined with medicinal chemistry has allowed the design of potent small molecule inhibitors which typically bind to the catalytic domain. Most of these inhibitors are at the early stages, but some have already a suitable profile to be used as chemical tools. Read More

View Article and Full-Text PDF

Diastereoselective Direct Catalytic Asymmetric Mannich-Type Reactions of Alkylnitriles with a Ni(II)-Carbene Complex.

Org Lett 2022 May 24. Epub 2022 May 24.

Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.

Despite recent advances in reactions using alkylnitriles as carbon nucleophiles, diastereoselective direct catalytic asymmetric reactions, in which two consecutive chiral centers could be controlled, remain largely unexplored. Herein, we report the addition of alkylnitriles (such as propionitrile) to imines in the presence of a catalytic amount of a chiral pincer-type Ni-carbene complex and potassium 2,6-di--butyl-4-methylphenoxide (KBHT). BHT and molecular sieves were used as additives to improve the yields, diastereoselectivity, and enantiomeric ratio up to >99%, 90:10 /, and 97. Read More

View Article and Full-Text PDF

Insights gained in the pathology of lung disease through single cell transcriptomics.

J Pathol 2022 May 24. Epub 2022 May 24.

Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

The human lung is a relatively quiescent organ in the normal healthy state but contains stem/progenitor cells that contribute to normal tissue maintenance and either repair or remodeling in response to injury and disease. Maintenance or repair lead to proper restoration of functional lung tissue and maintenance of physiological functions, with remodeling resulting in altered structure and function that is typically associated with disease. Knowledge of cell types contributing to lung tissue maintenance and repair/remodeling have largely relied on mouse models of injury-repair and lineage tracing of local progenitors. Read More

View Article and Full-Text PDF

Divergent Rabies Virus Variant of Probable Bat Origin in 2 Gray Foxes, New Mexico, USA.

Emerg Infect Dis 2022 Jun;28(6):1137-1145

In the Western Hemisphere, bat-associated rabies viruses (RABVs) have established independent transmission cycles in multiple mammal hosts, forming genetically distinct lineages. In New Mexico, USA, skunks, bats, and gray foxes are rabies reservoir hosts and represent a public health risk because of encounters with humans. During 2015 and 2019, two previously undescribed RABVs were detected in 2 gray foxes (Urocyon cinereoargenteus) in Lincoln County, New Mexico. Read More

View Article and Full-Text PDF

[Mammoth "de-extinction", a "Colossal" hoax?]

Bertrand Jordan

Med Sci (Paris) 2022 May 24;38(5):480-483. Epub 2022 May 24.

Biologiste, généticien et immunologiste, président d'Aprogène (Association pour la promotion de la génomique), 13007 Marseille, France.

Reports of a mammoth cloning project on-going under George Church's supervision appear periodically in the press. Close examination of the available evidence indicates that there is indeed such a project (carried out in a company called "Colossal"), but the aim is actually to modify the Asian elephant's genome so that the resulting animal displays some significant cold-adaptation traits, could theoretically be reintroduced into Siberia, and would then (also theoretically) modify the biotope towards its initial state of a steppe rather than a tundra. This endeavour seems largely unfeasible, but it may trigger important methodological advances that probably explain its ability to attract significant capital investment. Read More

View Article and Full-Text PDF

Tunable Green Light-Emitting CsPbBr Based Perovskite-Nanocrystals-in-Glass Flexible Film Enables Production of Stable Backlight Display.

J Phys Chem Lett 2022 May 24:4701-4709. Epub 2022 May 24.

College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.

Despite recent advances in producing perovskite-nanocrystals-in-glass (PNG) for display application, it remains challenging to achieve ultrapure and large-area CsPbBr PNG-based flexible films with tunable green emission. Herein, we report a facile strategy to produce flexible film containing CsPbBr PNG. Specifically, the achievement of CsPbBr PNG with tunable green emissions (517-528 nm) is realized by elaborate regulation of the glass precursor concentration and thermal treatment temperature by an in situ growth method. Read More

View Article and Full-Text PDF

Advances in the OCEAN-3 spectroscopy package.

John Vinson

Phys Chem Chem Phys 2022 May 24. Epub 2022 May 24.

Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

The OCEAN code for calculating valence- and core-level spectra using the Bethe-Salpeter equation is briefly reviewed. OCEAN is capable of calculating optical absorption, near-edge X-ray absorption or non-resonant scattering, and resonant inelastic X-ray scattering, requiring only the structure of the material as input. Improved default behavior and reduced input requirements are detailed as well as new capabilities, such as incorporation of final-state-dependent broadening, finite-temperature dependence, and flexibility in the density-functional theory exchange-correlation potentials. Read More

View Article and Full-Text PDF