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Adv Med Sci 2022 May 17;67(2):229-233. Epub 2022 May 17.

Department of Pediatric Surgery and Urology, Medical University of Bialystok, Bialystok, Poland.

Purpose: Recent increase in incidence of meningiomas suggests the need to search for new risk factors. Leptin, a potentially pro-angiogenic and proliferative agent, could be a candidate for this role, as its expression correlates with body mass index (BMI). Because development of meningioma has also been linked to sex hormones, bisphenol A (BPA), a known xenoestrogen, can also be taken into consideration as a potential risk factor. Read More

Adv Med Sci 2022 May 17;67(2):216-228. Epub 2022 May 17.

Department of Physiology, Medical University of Bialystok, Bialystok, Poland.

Purpose: Adipose tissue's (AT) structural changes accompanying obesity may alter lipid transport protein expression and, thus, the fatty acids (FAs) transport and lipid balance of the body. Metabolic abnormalities within AT contribute to the elevated production of reactive oxygen species and increased oxidative/nitrosative stress. Although compounds such as N-acetylcysteine (NAC) and α-lipoic acid (ALA), which restore redox homeostasis, may improve lipid metabolism in AT, the mechanism of action of these antioxidants on lipid metabolism in AT is still unknown. Read More

Adv Med Sci 2022 May 11;67(2):208-215. Epub 2022 May 11.

Department of Nephrology, Dialysis and Internal Diseases, Medical University of Warsaw, Warsaw, Poland. Electronic address:

Purpose: Over the last few years, transplant centers have started to use various intraoperative renal replacement therapy (ioRRT) modalities during liver transplantation (LT) in patients with pre-existing renal impairment. Here, we present a study on the safety and clinical outcomes of intraoperative hemodialysis (ioHD) performed using a mobile dialysis system during LT.

Patients And Methods: We retrospectively analyzed 102 adult patients undergoing LT with ioHD; pre-existing renal failure and/or intraoperative metabolic derangement were ioHD treatment indications. Read More

Adv Med Sci 2022 Apr 24;67(2):203-207. Epub 2022 Apr 24.

Department of Gastroenterology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland. Electronic address:

Purpose: Wilson's disease (WD) is an inherited disorder involving copper accumulation in the liver and brain. An important mechanism responsible for hepatocyte injury in WD is mitochondria destruction, although damage may also be caused by oxidative stress and lipid peroxidation.

Patients/methods: The study included 54 treated patients with WD without liver cirrhosis and 10 healthy controls. Read More

Adv Med Sci 2022 Apr 11;67(2):196-202. Epub 2022 Apr 11.

Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.

Notch signaling is a highly conserved pathway and it plays an essential role in regulating cellular proliferation, differentiation, and apoptosis. The human Notch family includes four receptors, Notch 1-4, and five ligands, delta-like ligand 1 (DLL1), delta-like ligand 3 (DLL3), delta-like ligand 4 (DLL4), Jagged-1 (JAG1), and Jagged-2 (JAG2). It is widely known, that Notch signaling components are often mutated and have deregulated expression in many types of cancer and other diseases. Read More

Adv Med Sci 2022 Apr 7;67(2):187-195. Epub 2022 Apr 7.

Department of Orthopedic Oncology, the Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China; Qingdao Medical College of Qingdao University, Qingdao, People's Republic of China. Electronic address:

Purpose: Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) plays a crucial role in many kinds of tumors. The relationship between Siglec-15 and the prognosis of osteosarcoma patients and its role in the apoptosis and pyroptosis of osteosarcoma cells are not sufficiently understood. Our study aimed to investigate the function of Siglec-15 in osteosarcoma cells and its effect on tumor cell proliferation, apoptosis and pyroptosis. Read More

Adv Med Sci 2022 Mar 17;67(1):179-186. Epub 2022 Mar 17.

Department of Pediatric Surgery and Pediatric Urology, Upper Silesian Child Health Centre, School of Medicine in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.

Purpose: Pectus excavatum is a frequent thoracic malformation increasingly treated with minimally invasive methods (MIRPE), which are performed for cardio-respiratory problems and in some centers also for esthetic considerations. Theoretically, MIRPE may increase thoracic elastic recoil, work of breathing and cause emphysema. The aim of the present study was to determine whether teenagers who underwent MIRPE may expect normal thoracic cage development, cardio-respiratory function, exercise capacity and asymptomatic functioning. Read More

Adv Med Sci 2022 Mar 12;67(1):170-178. Epub 2022 Mar 12.

Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Purpose: The immunosuppressive microenvironment of tumors reduces the effectiveness of immunotherapies. Apelin as an immunosuppressor peptide is expressed in the microenvironment of many tumors. Thus, inhibition of apelin-related protumor activities can promote the effectiveness of cancer immunotherapy. Read More

Adv Med Sci 2022 Mar 10;67(1):163-169. Epub 2022 Mar 10.

Department of Microbiology and Medical Laboratory Immunology, Medical University of Lodz, Lodz, Poland.

Purpose: The variation in the immune response to Bartonella spp. infection in humans remains unclear. The present study compares the expression of selected interleukins, cytokines and cathelicidin (LL-37) in rheumatology clinic patients suffering from musculoskeletal symptoms with healthy blood donors. Read More

Adv Med Sci 2022 Mar 8;67(1):154-162. Epub 2022 Mar 8.

Division of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Vienna Hepatic Hemodynamic Experimental (HEPEX) Laboratory, Medical University of Vienna, Vienna, Austria; Christian-Doppler Laboratory for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Ludwig Boltzmann Institute, Vienna, Austria; CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria. Electronic address:

Purpose: Portal hypertension (PH)-associated splenomegaly is caused by portal venous congestion and splanchnic hyperemia. This can trigger hypersplenism, which favors the development of cytopenia. We investigated the time-dependent impact of splenectomy on portal pressure and blood cell counts in animal models of non-cirrhotic and cirrhotic PH. Read More

Adv Med Sci 2022 Mar 2;67(1):148-153. Epub 2022 Mar 2.

1st Department of Obstetrics and Gynaecology, Medical University of Warsaw, Warsaw, Poland; Oviklinika Infertility Center, Warsaw, Poland. Electronic address:

Purpose: The purpose of this article is to provide a modern perspective on the diagnosis of endometriosis with particular attention to the role of ultrasound examination. In the present study, we highlight the problem of endometriosis in teenage girls and discuss the patients' perspective on the diagnostic process.

Methods: In order to present the most recent reports on the diagnosis of endometriosis, the PubMed database was searched. Read More

Adv Med Sci 2022 Mar 2;67(1):142-147. Epub 2022 Mar 2.

Department of Biology, Lund University, Lund, Sweden; SGP + Group, Trelleborg, Sweden; Department of Animal Physiology, The Kielanowski Institute of Animal Nutrition and Physiology Polish Academy of Sciences, Jabłonna, Poland. Electronic address:

Purpose: Nitrogen (N) is an indispensable metabolite required for the synthesis of protein. In animals, gut bacteria and, to a certain extent, even hepatocytes, are able to assimilate nitrogen from ammonium (NH), which is essentially derived from the amine group (-NH) and which is at the same time a very toxic metabolite. Initially, NH is coupled to alpha-ketoglutarate (AKG), a reaction which results in the appearance of glutamate (one amine group), and after that, in the appearance of glutamine - containing two amine groups. Read More

Adv Med Sci 2022 03 22;67(1):139-141. Epub 2022 Feb 22.

Department of Health Sciences Investigation, Sanatorio Metropolitano, Fernando de la Mora, Paraguay; Division of Cardiovascular Medicine, Clinical Hospital, Asunción National University (UNA), San Lorenzo, Paraguay. Electronic address:

Adv Med Sci 2022 Mar 23;67(1):129-138. Epub 2022 Feb 23.

Laboratory of Processing and Analysis of Microscopic Images, Nalecz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland.

Background: Inflammatory myofibroblastic tumors (IMTs) are rare intermediate-grade neoplasms that have a high recurrence rate after excision and exhibit low metastatic potential. These tumors contain proliferating neoplastic, fibroblastic and myofibroblastic cells, and are also characterized by chronic inflammatory infiltration by lymphocytes, plasma cells, eosinophils, and histiocytes. They belong to the group of inflammatory spindle cell lesions. Read More

Adv Med Sci 2022 Mar 5;67(1):123-128. Epub 2022 Feb 5.

Department of Clinical Endocrinology, Medical University of Lodz, Lodz, Poland. Electronic address:

Purpose: Polycystic ovary syndrome (PCOS) is associated with an increased risk of cardiovascular disease (CVD) and metabolic complications often related to obesity, such as insulin resistance and type 2 diabetes mellitus (T2DM). Sirtuins (SIRTs) are nicotinamide adenine dinucleotide NAD-dependent histone deacetylases, which modulate protein post-translational modifications (PTMs), gene transcription, increase repairing activities of DNA, and regulate metabolic processes. The aim of our study was to measure the serum levels of SIRTs 1, 2, 3, 6 and 7, and evaluate correlations between SIRTs levels and cardiovascular risk factors in women with PCOS. Read More

Adv Med Sci 2022 Mar 5;67(1):114-122. Epub 2022 Feb 5.

3rd Surgical Department, "AHEPA" University Hospital, Medical Faculty, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Purpose: We aim to present a comprehensive literature review which focuses on the preoperative imaging of perianal fistulas.

Material/methods: Pelvic magnetic resonance imaging (MRI) and endoanal ultrasound (EAUS) are the two first-line imaging modalities for the preoperative evaluation of patients with perianal fistulas. We conducted a search in PubMed, Scopus and Google Scholar concerning articles comparing pelvic MRI with EAUS, which were published from 1994 until 2019. Read More

Adv Med Sci 2022 Mar 1;67(1):103-113. Epub 2022 Feb 1.

Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Shandong, Dezhou, China. Electronic address:

Purpose: With the increasing incidence of thyroid cancer (TC), the prognostic risk assessment of thyroid cancer has been becoming more and more important. The aim of this study was to screen TC-related biomarkers and identify key multi-long non coding RNA (lncRNA) signature for prognostic risk assessment of papillary TC.

Material And Methods: The lncRNAs differentially expressed between TC tissue and adjacent normal tissue was identified by R language. Read More

Adv Med Sci 2022 Mar 28;67(1):95-102. Epub 2022 Jan 28.

Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland.

Background: Patients with acute decompensated heart failure (ADHF) are at severe risk of death and rehospitalization. Several clinical studies have been designed to evaluate the efficacy and safety of new molecules administered before discharge or shortly after ADHF. The aim of this article is to summarize current knowledge on recently published findings on treatment of patients with heart failure with reduced ejection fraction (HFrEF) and ADHF. Read More

Adv Med Sci 2022 Mar 28;67(1):87-94. Epub 2022 Jan 28.

Department of Histology and Cytophysiology, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Many factors and molecular pathways are involved in the pathogenesis of arterial hypertension. The increase in blood pressure may be determined by the properties of specific gene products and their associated action with environmental factors. In recent years, much attention has been paid to the Wnt/β-catenin signaling pathway which is essential for organ damage repair and homeostasis. Read More

Adv Med Sci 2022 Mar 5;67(1):79-86. Epub 2022 Jan 5.

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: Polycystic ovary syndrome (PCOS) and hyperprolactinemia are the most frequent endocrine disorders in women which share several common features. There are inconsistent results regarding the existence of a possible pathophysiological interplay between these endocrinopathies and the elevation of prolactin (PRL) in PCOS. The purpose of this study was to explore the upper reference limit of PRL in PCOS women. Read More

Adv Med Sci 2022 Mar 5;67(1):66-78. Epub 2022 Jan 5.

Faculty of Finance and Management, WSB University in Gdansk, Gdansk, Poland.

Purpose: l-arginine (L-arg) deficiency causes immunosuppression, but it is unknown if L-arg supplementation in colorectal cancer (CRC) patients restores immune system activity. Our objective was to investigate the effect of L-arg supplementation on the frequency of monocytic (M) and polymorphonuclear (PNM) myeloid-derived suppressor cells (M-MDSCs and PMN-MDSCs, respectively).

Methods: We enrolled 65 CRC patients (34 males, 31 females) aged 69 ​± ​10 years into a prospective, randomised, double-blind study. Read More

Adv Med Sci 2022 Mar 31;67(1):55-65. Epub 2021 Dec 31.

2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.

Background: This article aims to reveal misconceptions about methods of assessment of hydration status and impact of the water disorders on the progression of kidney disease or renal dysfunction.

Materials And Methods: The PubMed database was searched for reviews, meta-analyses and original articles on hydration, volume depletion, fluid overload and diagnostic methods of hydration status, which were published in English.

Results: Based on the results of available literature the relationship between the amount of fluid consumed, and the rate of progression of chronic kidney disease, autosomal dominant polycystic kidney disease, and kidney stones disease was discussed. Read More

Adv Med Sci 2022 Mar 28;67(1):45-54. Epub 2021 Dec 28.

Department of Immunology, Medical University of Bialystok, Bialystok, Poland.

Purpose: The actual role of neutrophils and neutrophil extracellular traps (NETs) in the course of cancer has not been clearly defined. The aim of this study was to determine the clinical usefulness of NETs biomarkers in saliva in confrontation with the blood serum and tumor tissue as a potential prognostic and therapeutic target in patients with oral squamous cell carcinoma (OSCC).

Material And Methods: Expression of myeloperoxidase (MPO), and histones H2A, H2B, H3 in the tumor tissue, was investigated using immunohistochemistry. Read More

Adv Med Sci 2022 Mar 11;67(1):39-44. Epub 2021 Dec 11.

General Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, Padua University Hospital, Padua, Italy. Electronic address:

Purpose: Coronavirus disease 2019 (COVID-19) is a systemic inflammatory condition associated with coagulopathy which may result in severe thromboembolic complications. Cardiac injury is not uncommon in hospitalized COVID-19 patients and therefore we aimed to investigate whether it stems from an abnormal coagulative state.

Materials And Methods: We conducted a retrospective cross-sectional study on consecutive patients hospitalized due to COVID-19. Read More

Adv Med Sci 2022 Mar 13;67(1):29-38. Epub 2021 Nov 13.

Department of Reproductive Medicine Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Purpose: Oxidative damage and intestinal flora dysbiosis play important roles in the progression of chronic ulcerative colitis (UC). This study explored the effect and mechanism of molecular hydrogen in chronic UC.

Materials And Methods: Male C57BL/6 mice (19. Read More

Adv Med Sci 2022 Mar 12;67(1):23-28. Epub 2021 Nov 12.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.

Purpose: In anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), there is a lack of reliable biomarkers of disease activity. The aim of the study was to evaluate soluble urokinase plasminogen activator receptor (suPAR) and anti-endothelin-1 type A receptor (anti-ETAR) antibodies levels in active phase and remission of AAV.

Patients And Methods: We enrolled 60 patients (median age 63. Read More

Adv Med Sci 2022 Mar 14;67(1):18-22. Epub 2021 Oct 14.

Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.

Purpose: Clinical practice forces the necessity to conduct a clinical trial concerning the group of outpatients with chronically advanced heart failure in III or IV NYHA functional class, frequently requiring hospitalizations due to HF exacerbation, and often left without any additional therapeutic option. The current trial aims to determine the efficacy and safety of repeated levosimendan infusions in the group of severe outpatients with reduced ejection fraction (HFrEF).

Material And Methods: LEIA-HF (LEvosimendan In Ambulatory Heart Failure Patients) is a multicentre, randomized, double-blind, placebo-controlled, phase 4 clinical trial to determine whether the repetitive use of levosimendan reduces the incidence of adverse cardiovascular events in ambulatory patients with chronic, advanced HFrEF. Read More

Adv Med Sci 2021 Sep 28;66(2):424-431. Epub 2021 Sep 28.

Department of Prevention of Environmental Hazards and Allergology, Faculty of Medical Science, Medical University of Warsaw, Warsaw, Poland.

Purpose: The role of infectious agents in allergy development is ambivalent. On one hand, there are reports of an association between a previous infection (especially a viral respiratory tract infection) and developing hypersensitivity to inhaled allergens, which in turn may increase the risk of developing allergic reactions. On the other hand, there are reports emphasizing a protective effect of a number of infectious agents against allergy development. Read More

Adv Med Sci 2022 Mar 22;67(1):10-17. Epub 2021 Sep 22.

Institute of Health Sciences, Interdisciplinary Food, Metabolism and Clinical Nutrition Department, Ankara University Faculty of Medicine, Ankara, Turkey; Department of Pathophysiology, Faculty of Medicine, Ankara University, Ankara, Turkey. Electronic address:

Purpose: Developing a vaccine with improved immunogenicity is still a growing priority for many diseases. Different types of adjuvants may be beneficial to initiate and maintain the long-lasting immunogenicity of vaccines. Evidence has shown that polysaccharide adjuvants are efficient in improving immunological mechanisms with their biocompatibility and biodegradability characteristics. Read More

Adv Med Sci 2022 Mar 22;67(1):1-9. Epub 2021 Sep 22.

Centre for Research in Biomedicine, University of the West of England, Frenchay, Bristol, United Kingdom. Electronic address:

Purpose: Antibiotic resistance is widespread throughout the world and represents a serious health concern. There is an urgent need for the development of novel tools for rapidly distinguishing antibiotic resistant bacteria from susceptible strains. Previous work has demonstrated that differences in antimicrobial susceptibility can be reflected in differences in the profile of volatile organic compounds (VOCs) produced by dissimilar strains. Read More