15 results match your criteria Advances in Infectious Diseases

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Management of fever and neutropenia in the adult patient with acute myeloid leukemia.

Expert Rev Anti Infect Ther 2020 Oct 5:1-20. Epub 2020 Oct 5.

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine , Indianapolis, IN, USA.

Introduction: Febrile neutropenia represents one of the most common treatment-associated complications in the management of acute myeloid leukemia (AML) and is considered an oncologic emergency. Rapid and detailed workup as well as the initiation of empiric broad-spectrum antibiotic therapy are critical to avoid sepsis and to reduce mortality. Although a definitive source of infection is frequently not identified, the severely immunosuppressed status of the AML patient undergoing cytotoxic therapy results in a high risk for a wide array of bacterial, fungal, and viral etiologies. Read More

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http://dx.doi.org/10.1080/14787210.2020.1820863DOI Listing
October 2020

Viruses in the Built Environment (VIBE) meeting report.

Microbiome 2020 01 4;8(1). Epub 2020 Jan 4.

Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA, 24061, USA.

Background: During a period of rapid growth in our understanding of the microbiology of the built environment in recent years, the majority of research has focused on bacteria and fungi. Viruses, while probably as numerous, have received less attention. In response, the Alfred P. Read More

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http://dx.doi.org/10.1186/s40168-019-0777-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942371PMC
January 2020

Real-time Epidemic Forecasting: Challenges and Opportunities.

Health Secur 2019 Jul/Aug;17(4):268-275

Britta Lassmann, MD, is Program Director, International Society for Infectious Diseases, Boston, MA.

Infectious disease outbreaks play an important role in global morbidity and mortality. Real-time epidemic forecasting provides an opportunity to predict geographic disease spread as well as case counts to better inform public health interventions when outbreaks occur. Challenges and recent advances in predictive modeling are discussed here. Read More

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http://dx.doi.org/10.1089/hs.2019.0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708259PMC
May 2020
3 Reads

What causes severe malaria and its complications in children? Lessons learned over the past 15 years.

BMC Med 2019 03 7;17(1):52. Epub 2019 Mar 7.

Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, 1044 W Walnut St R4 402D, Indianapolis, IN, USA.

Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which occur in African children under 5 years of age. Significant advances in understanding the pathogenesis of the disease provide a basis for future work to prevent severe malaria and its complications. Read More

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http://dx.doi.org/10.1186/s12916-019-1291-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404293PMC
March 2019
7 Reads

Mapping malaria by combining parasite genomic and epidemiologic data.

BMC Med 2018 10 18;16(1):190. Epub 2018 Oct 18.

Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

Background: Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spatial patterns of malaria transmission in elimination settings, with control programs having to accurately identify remaining foci in order to efficiently target interventions.

Findings: The role of connectivity between different pockets of local transmission is of increasing importance as programs near elimination since humans are able to transfer parasites beyond the limits of mosquito dispersal, thus re-introducing parasites to previously malaria-free regions. Read More

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https://www.biorxiv.org/content/early/2018/03/26/288506.full
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https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s129
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https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s129
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https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291
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http://dx.doi.org/10.1186/s12916-018-1181-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193293PMC
October 2018
32 Reads

Developments in the Diagnostic Techniques of Infectious Diseases: Rural and Urban Prospective.

Adv Infect Dis 2018 Sep 23;8(3):121-138. Epub 2018 Aug 23.

College of Arts and Sciences American University, Washington DC, USA.

Objectives: Diagnostics is the first step for the treatment and eradication of infectious microbial diseases. Due to ever evolving pathogens and emerging new diseases, there is an urgent need to identify suitable diagnostic techniques for better management of each disease. The success rate of specific diagnostic technique in any population depends on various factors including type of the microbial pathogen, availability of resources, technical expertise, disease severity and degree of epidemic of disease in the area. Read More

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http://dx.doi.org/10.4236/aid.2018.83012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124492PMC
September 2018
27 Reads

Hijacking of the Host Ubiquitin Network by .

Front Cell Infect Microbiol 2017 5;7:487. Epub 2017 Dec 5.

Center of Infection and Immunity, First Hospital, Jilin University, Changchun, China.

Protein ubiquitination is critical for regulation of numerous eukaryotic cellular processes such as protein homeostasis, cell cycle progression, immune response, DNA repair, and vesicular trafficking. Ubiquitination often leads to the alteration of protein stability, subcellular localization, or interaction with other proteins. Given the importance of ubiquitination in the regulation of host immunity, it is not surprising that many infectious agents have evolved strategies to interfere with the ubiquitination network with sophisticated mechanisms such as functional mimicry. Read More

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http://dx.doi.org/10.3389/fcimb.2017.00487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770618PMC
December 2018
6 Reads

A Roadmap for Tick-Borne Flavivirus Research in the "Omics" Era.

Front Cell Infect Microbiol 2017 22;7:519. Epub 2017 Dec 22.

Department of Entomology, Purdue University, West Lafayette, IN, United States.

Tick-borne flaviviruses (TBFs) affect human health globally. Human vaccines provide protection against some TBFs, and antivirals are available, yet TBF-specific control strategies are limited. Advances in genomics offer hope to understand the viral complement transmitted by ticks, and to develop disruptive, data-driven technologies for virus detection, treatment, and control. Read More

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http://dx.doi.org/10.3389/fcimb.2017.00519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744076PMC
December 2018
23 Reads

How innate immunity proteins kill bacteria and why they are not prone to resistance.

Curr Genet 2018 Feb 24;64(1):125-129. Epub 2017 Aug 24.

Indiana University School of Medicine - Northwest, Gary, IN, 46408, USA.

Recent advances on antibacterial activity of peptidoglycan recognition proteins (PGRPs) offer some insight into how innate immunity has retained its antimicrobial effectiveness for millions of years with no frequent emergence of resistant strains. First, PGRP can bind to multiple components of bacterial envelope (peptidoglycan, lipoteichoic acid, and lipopolysaccharide). Second, PGRP simultaneously induces oxidative, thiol, and metal stress responses in bacteria, which individually are bacteriostatic, but in combination are bactericidal. Read More

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http://link.springer.com/10.1007/s00294-017-0737-0
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http://dx.doi.org/10.1007/s00294-017-0737-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777906PMC
February 2018
28 Reads

MicroRNAs in neutrophils: potential next generation therapeutics for inflammatory ailments.

Immunol Rev 2016 09;273(1):29-47

Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.

Neutrophils play fundamental roles in both acute and chronic inflammatory conditions, and directly contribute to the immune pathologies in both infectious and autoimmune ailments. MicroRNAs (miRs) regulate homeostasis in health and disease by fine tuning the expression of a network of genes through post-transcriptional regulation. Many miRs are expressed in restricted tissues, regulated by stress and disease, and are emerging as mediators for intercellular communication. Read More

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http://dx.doi.org/10.1111/imr.12450DOI Listing
September 2016
14 Reads

Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis.

BMC Med 2016 Jan 28;14:14. Epub 2016 Jan 28.

Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.

Background: The current WHO-led initiative to eradicate the macroparasitic disease, lymphatic filariasis (LF), based on single-dose annual mass drug administration (MDA) represents one of the largest health programs devised to reduce the burden of tropical diseases. However, despite the advances made in instituting large-scale MDA programs in affected countries, a challenge to meeting the goal of global eradication is the heterogeneous transmission of LF across endemic regions, and the impact that such complexity may have on the effort required to interrupt transmission in all socioecological settings.

Methods: Here, we apply a Bayesian computer simulation procedure to fit transmission models of LF to field data assembled from 18 sites across the major LF endemic regions of Africa, Asia and Papua New Guinea, reflecting different ecological and vector characteristics, to investigate the impacts and implications of transmission heterogeneity and complexity on filarial infection dynamics, system robustness and control. Read More

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http://dx.doi.org/10.1186/s12916-016-0557-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731922PMC
January 2016
15 Reads

Recent advances in phlebotomine sand fly research related to leishmaniasis control.

Parasit Vectors 2015 Feb 27;8:131. Epub 2015 Feb 27.

Kuvin Center for the study of Infectious & Tropical Diseases, Institute of Medical Research Israel-Canada/ Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem, Jerusalem, 91120, Israel.

Phlebotomine sand flies are the subject of much research because of the role of their females as the only proven natural vectors of Leishmania species, the parasitic protozoans that are the causative agents of the neglected tropical disease leishmaniasis. Activity in this field was highlighted by the eighth International Symposium on Phlebotomine Sand flies (ISOPS) held in September 2014, which prompted this review focusing on vector control. Topics reviewed include: Taxonomy and phylogenetics, Vector competence, Genetics, genomics and transcriptomics, Eco-epidemiology, and Vector control. Read More

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http://www.parasitesandvectors.com/content/8/1/131
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http://dx.doi.org/10.1186/s13071-015-0712-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352286PMC
February 2015
18 Reads

Utilizing Healthcare Developments, Demographic Data with Statistical Techniques to Estimate the Diarrhoea Prevalence in India.

Adv Infect Dis 2012 Mar;2(1):1-8

College of Arts and Sciences, American University, Washington DC, USA.

Diarrhoea is one of the leading causes of morbidity and mortality in developing countries in Africa and South Asia such as India. Prevalence of diarrheal diseases in those countries is higher than developed western world and largely has been associated with socio-economic and sanitary conditions. However, present available data has not been sufficiently evaluated to study the role of other factors like healthcare development, population density, sex and regional influence on diarrheal prevalence pattern. Read More

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http://dx.doi.org/10.4236/aid.2012.21001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180416PMC
March 2012
14 Reads

Drug discovery and development of antiviral agents for the treatment of chronic hepatitis B virus infection.

Prog Drug Res 2001 ;Spec No:111-83

Infectious Diseases Research, Lilly Research Laboratories, Indianapolis, IN, USA.

A safe and effective vaccine for hepatitis B virus (HBV) has been available for nearly twenty years and currently campaigns to provide universal vaccination in developing countries are underway. Nevertheless, chronic HBV infection remains a leading cause of chronic hepatitis worldwide and there is a strong need for safe and effective antiviral therapies. Attempts to identify and develop antiviral agents to treat chronic HBV infection remains focused on nucleoside analogs such as 3TC (lamivudine), adefovir dipivoxil, (bis-POMPMEA), and others. Read More

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http://dx.doi.org/10.1007/978-3-0348-7784-8_4DOI Listing
September 2001
4 Reads

Cellular immune mechanisms in the pathogenesis of Crohn's disease.

Authors:
S P James

In Vivo 1988 Jan-Feb;2(1):1-7

Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Crohn's disease is a chronic relapsing inflammatory disease of the intestine of unknown cause. It has been suggested that the disease may result from an abnormality of the immunological functions of the gut. Recent advances in the study of the gastrointestinal immune system show that T cells in the intestinal mucosa are more activated, contain a higher proportion of T4 cells having the phenotypic and functional characteristics of helper-inducer cells, have greater capacity for IL-2 production, and have altered responsiveness to antigen stimulation. Read More

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March 1992
6 Reads
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