265 results match your criteria Advances in Hematology [Journal]


Effect of Imatinib on Bone Marrow Morphology and Angiogenesis in Chronic Myeloid Leukemia.

Adv Hematol 2019 1;2019:1835091. Epub 2019 Jan 1.

Department of Biostatistics & Health Informatics, Sanjay Gandhi Post Graduate of Medical Sciences, Raebareli Road, Lucknow, U.P. 226014, India.

Background And Objectives: Chronic myeloid leukemia (CML) is characterized by hyperproliferation of myeloid precursors, increased fibrosis, and neoangiogenesis in the bone marrow. Imatinib inhibits BCR-ABL tyrosine kinase produced due to reciprocal translocation t(9;22) in neoplastic CML cells. It reduces hyperproliferation of myeloid precursors and has been found to affect bone marrow fibrosis and angiogenesis. Read More

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https://www.hindawi.com/journals/ah/2019/1835091/
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http://dx.doi.org/10.1155/2019/1835091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332991PMC
January 2019
4 Reads

Traceability of Blood Transfusions and Reporting of Adverse Reactions in Developing Countries: A Six-Year Postpilot Phase Experience in Burkina Faso.

Adv Hematol 2018 20;2018:7938130. Epub 2018 Dec 20.

CHU UCL Namur asbl, 15 place L. Godin, 5000 Namur, Belgium.

Traceability is an essential tool for haemovigilance and transfusion safety. In Burkina Faso, the implementation of haemovigilance has been achieved as part of a pilot project from 2005 to 2009. Our study aims to evaluate the traceability of blood transfusions and reporting of adverse reactions over the 6-year postpilot phase. Read More

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http://dx.doi.org/10.1155/2018/7938130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317082PMC
December 2018
2 Reads

Burden of Sickle Cell Disease in Ghana: The Korle-Bu Experience.

Adv Hematol 2018 2;2018:6161270. Epub 2018 Dec 2.

Ghana Institute of Clinical Genetics, Korle-Bu, Accra, Ghana.

In Africa, sickle cell disease (SCD) is a major public health problem with over 200,000 babies born per year. In Ghana, approximately 15,000 (2%) of Ghanaian newborns are diagnosed with SCD annually. A retrospective review of medical records of all SCD patients aged 13 years and above, who presented to the sickle cell clinic at Ghana Institute of Clinical Genetics (GICG), Korle-Bu, from 1st January 2013 to 31st December 2014, was carried out, using a data abstraction instrument to document their phenotypes, demographics, attendance/clinic visits, pattern of attendance, and common complications seen. Read More

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https://www.hindawi.com/journals/ah/2018/6161270/
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http://dx.doi.org/10.1155/2018/6161270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304501PMC
December 2018
11 Reads

A Novel Approach for Objective Assessment of White Blood Cells Using Computational Vision Algorithms.

Adv Hematol 2018 13;2018:4716370. Epub 2018 Nov 13.

KINESTASIS Seedlings of Research, University of Cundinamarca, Fusagasugá, Colombia.

In the field of medicine, the analysis of blood is one of the most important exams to determine the physiological state of a patient. In the analysis of the blood sample, an important process is the counting and classification of white blood cells, which is done manually, being an exhaustive, subjective, and error-prone activity due to the physical fatigue that generates the professional because it is a method that consumes long laxes of time. The purpose of the research was to develop a system to identify and classify blood cells, by the implementation of the networks of Gaussian radial base functions (RBFN) for the extraction of its nucleus and subsequently their classification through the morphological characteristics, its color, and the distance between objects. Read More

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http://dx.doi.org/10.1155/2018/4716370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257897PMC
November 2018
3 Reads

The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes.

Adv Hematol 2018 1;2018:2458679. Epub 2018 Nov 1.

Medical University of Varna, Varna, Bulgaria.

Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by ineffective hematopoiesis and a wide spectrum of manifestations ranging from indolent and asymptomatic cytopenias to acute myeloid leukemia (AML). MDS result from genetic and epigenetic derangements in clonal cells and their surrounding microenvironments. Studies have shown associations between MDS and other autoimmune diseases. Read More

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http://dx.doi.org/10.1155/2018/2458679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241340PMC
November 2018
4 Reads

Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes.

Adv Hematol 2018 10;2018:8487403. Epub 2018 Oct 10.

Celgene International Holdings Corporation, 125047 Moscow, Russia.

We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease. Read More

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https://www.hindawi.com/journals/ah/2018/8487403/
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http://dx.doi.org/10.1155/2018/8487403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199869PMC
October 2018
6 Reads

Vitamin D and Nonskeletal Complications among Egyptian Sickle Cell Disease Patients.

Adv Hematol 2018 16;2018:3867283. Epub 2018 Sep 16.

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.

Lower levels of vitamin D have been documented in many patients with sickle cell disease (SCD), but data are still inconclusive regarding the association between vitamin D deficiency (VDD) and the occurrence or the severity of various SCD complications. Our study aimed to detect the prevalence of vitamin D deficiency among Egyptian patients with SCD and to associate it with the clinical course of the disease. We measured the level of 25-hydroxy vitamin D in 140 children (age from 4. Read More

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https://www.hindawi.com/journals/ah/2018/3867283/
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http://dx.doi.org/10.1155/2018/3867283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164208PMC
September 2018
3 Reads

Prevalence and Factors Associated with Anemia among Pregnant Women Attending Antenatal Clinic at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Adv Hematol 2018 29;2018:3942301. Epub 2018 Aug 29.

Department of Medical Laboratory Sciences, College of Health Science, Addis Ababa University, Ethiopia.

Background: In pregnancy, anemia is an important factor associated with an increased risk of maternal, fetal, and neonatal mortality, poor pregnancy outcomes, and impaired cognitive development, particularly in developing countries like Ethiopia. This study aimed to assess prevalence and factors associated with anemia among pregnant women attending antenatal clinic at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.1155/2018/3942301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136568PMC
August 2018
11 Reads

The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests.

Adv Hematol 2018 2;2018:6940152. Epub 2018 Jul 2.

Department of Pathology, Chettinad Health City and Research Institute, Kelambakkam, Chennai, Tamil Nadu, India.

Background: Automation helps improve laboratory operational efficiency and reduce the turnaround time. Pneumatic tube systems (PTS) automate specimen transport between the lab and other areas of the hospital. Its effect on complete blood count (CBC) and coagulation is still controversial. Read More

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http://dx.doi.org/10.1155/2018/6940152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051325PMC
July 2018
2 Reads

Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine.

Adv Hematol 2018 6;2018:5356245. Epub 2018 Jun 6.

Department of Medical Technology, Faculty of Allied Health Sciences, Arab American University in Jenin, State of Palestine.

Background: Transfusion of red blood cells (RBC) is an essential therapeutic tool in sickle cell disease (SCD). Repeated RBC transfusions can cause alloimmunization which causes difficulty in cross-matching and finding compatible blood for transfusions. This study aimed to investigate the frequency of RBC alloimmunization and related risk factors among Palestinian SCD patients. Read More

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http://dx.doi.org/10.1155/2018/5356245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011130PMC
June 2018
21 Reads

Prevalence of Bleeding Symptoms among Adolescents and Young Adults in the Capital City of Saudi Arabia.

Adv Hematol 2018 2;2018:1858241. Epub 2018 May 2.

Center of Excellence in Thrombosis and Hemostasis, King Saud University, Riyadh, Saudi Arabia.

Background: Bleeding disorders vary in prevalence. While some are rare, some can be common in both sexes. Most bleeding disorders manifest as chronic bleeding tendencies or as an increase in bleeding during surgical procedures or trauma. Read More

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https://www.hindawi.com/journals/ah/2018/1858241/
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http://dx.doi.org/10.1155/2018/1858241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954960PMC
May 2018
30 Reads

Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma.

Adv Hematol 2018 5;2018:3864398. Epub 2018 Mar 5.

Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Central Jakarta 10430, Indonesia.

Introduction: Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Read More

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http://dx.doi.org/10.1155/2018/3864398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859798PMC
March 2018
5 Reads

Impact of Age on Outcomes in Hospitalized Patients with Hereditary Hemorrhagic Telangiectasia.

Adv Hematol 2018 11;2018:4798425. Epub 2018 Feb 11.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Scottsdale, AZ, USA.

Background: There is little published literature regarding the impact of age on outcomes amongst hospitalized HHT (hereditary hemorrhagic telangiectasia) patients.

Methods: The Nationwide Inpatient Sample (NIS) was used to obtain data on all hospital discharges occurring in HHT patients from 2000 to 2012. The association between admission age and HHT-related complications and outcomes were studied. Read More

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http://dx.doi.org/10.1155/2018/4798425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828469PMC
February 2018
12 Reads

Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis.

Adv Hematol 2017 6;2017:7878605. Epub 2017 Dec 6.

Department of Pediatrics, University Hospital of Ioannina, Ioannina, Greece.

Immune thrombocytopenia (ITP) in children has a varied course and according to duration is distinguished as newly diagnosed (<3 months), persistent (3-12), and chronic (>12) types. Several studies have evaluated the prognostic factors for the progression of the disease, but similar works have yet to be performed in Greece. We aimed to identify prognostic markers for the three forms of the disease in 57 Greek children during a 13-year period. Read More

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http://dx.doi.org/10.1155/2017/7878605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736937PMC
December 2017
8 Reads

Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy.

Adv Hematol 2017 8;2017:8690416. Epub 2017 Nov 8.

Stem Cell Transplant Program, Henry Ford Hospital, 2799 W. Grand Blvd, Detroit, MI 48202, USA.

In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. We undertook a retrospective analysis of 78 patients with myeloid malignancies who received fludarabine and busulfan (FluBu4) with or without measuring Bu pharmacokinetics (Bu PK) and those who received busulfan with cyclophosphamide (BuCy). Fifty-five patients received FluBu4, of whom 21 had Bu PK measured, and 23 patients received BuCy. Read More

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http://dx.doi.org/10.1155/2017/8690416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698787PMC
November 2017
13 Reads

Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients.

Adv Hematol 2017 24;2017:6527306. Epub 2017 Oct 24.

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Improved therapies are urgently needed for patients with diffuse large B cell lymphoma (DLBCL). Success using immune checkpoint inhibitors and chimeric antigen receptor T cell technology has fuelled demand for validated cancer epitopes. Immunogenic cancer testis antigens (CTAs), with their widespread expression in many tumours but highly restricted normal tissue distribution, represent attractive immunotherapeutic targets that may improve treatment options for DLBCL and other malignancies. Read More

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http://dx.doi.org/10.1155/2017/6527306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674480PMC
October 2017
13 Reads

Study of Erythrocyte Indices, Erythrocyte Morphometric Indicators, and Oxygen-Binding Properties of Hemoglobin Hematoporphyrin Patients with Cardiovascular Diseases.

Adv Hematol 2017 17;2017:8964587. Epub 2017 Jul 17.

GBUZ RM "National Hospital for War Veterans", Saransk 430005, Russia.

The current study investigates the functional state of erythrocytes and indices of the oxygen-binding capacity of hemoglobin in blood samples from healthy donors and from patients with coronary artery disease and myocardial infarction before and after treatment. It has been established that, in cardiovascular diseases, erythrocyte morphology and hemoglobin oxygen-transporting disorders are observed. Standard therapy does not result in the restoration of the structure and properties of erythrocytes. Read More

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https://www.hindawi.com/journals/ah/2017/8964587/
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http://dx.doi.org/10.1155/2017/8964587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535697PMC
July 2017
16 Reads

Outcomes of Six-Dose High-Dose Cytarabine as a Salvage Regimen for Patients with Relapsed/Refractory Acute Myeloid Leukemia.

Adv Hematol 2017 14;2017:6464972. Epub 2017 May 14.

Department of Pharmacy, West Virginia University Medicine, Morgantown, WV, USA.

Relapsed/refractory acute myeloid leukemia (RR-AML) is associated with poor prognosis and long-term disease-free survival requires allogeneic hematopoietic cell transplantation (allo-HCT). Limited data exists, regarding the optimal regimen to obtain remission prior to allo-HCT. Single agent high-dose cytarabine (10-12 doses administered every 12 hours) has been previously used as induction therapy. Read More

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http://dx.doi.org/10.1155/2017/6464972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446853PMC
May 2017
44 Reads

Efficacy and Safety of Manual Partial Red Cell Exchange in the Management of Severe Complications of Sickle Cell Disease in a Developing Country.

Adv Hematol 2017 11;2017:3518402. Epub 2017 May 11.

Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal.

Introduction: The realization of red cell exchange (RCE) in Africa faces the lack of blood, transfusion safety, and equipment. We evaluated its efficacy and safety in severe complications of sickle cell disease.

Patients And Method: Manual partial RCE was performed among sickle cell patients who had severe complications. Read More

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https://www.hindawi.com/journals/ah/2017/3518402/
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http://dx.doi.org/10.1155/2017/3518402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443989PMC
May 2017
9 Reads

The Evolution of Prognostic Factors in Multiple Myeloma.

Adv Hematol 2017 21;2017:4812637. Epub 2017 Feb 21.

King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Multiple myeloma (MM) is a heterogeneous hematologic malignancy involving the proliferation of plasma cells derived by different genetic events contributing to the development, progression, and prognosis of this disease. Despite improvement in treatment strategies of MM over the last decade, the disease remains incurable. All efforts are currently focused on understanding the prognostic markers of the disease hoping to incorporate the new therapeutic modalities to convert the disease into curable one. Read More

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http://dx.doi.org/10.1155/2017/4812637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339490PMC
February 2017
31 Reads

Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana.

Adv Hematol 2016 14;2016:7302912. Epub 2016 Sep 14.

Department of Medical Laboratory Technology, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.

Blood transfusion is a therapeutic procedure usually undertaken in patients with severe anaemia. In Ghana, severe anaemia is mostly due to malaria caused by severe infection, road traffic accidents, and haemoglobinopathy-induced acute haemolysis. This cross-sectional study evaluated coinheritance of sickle cell haemoglobin variant and G6PD enzymopathy among individuals that donated blood at the Holy Trinity Hospital, Berekum, in the Brong-Ahafo Region, Ghana. Read More

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http://dx.doi.org/10.1155/2016/7302912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039272PMC
September 2016
34 Reads

Autologous Graft-versus-Tumor Effect: Reality or Fiction?

Authors:
Luis F Porrata

Adv Hematol 2016 22;2016:5385972. Epub 2016 Aug 22.

Division of Hematology, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

In contrast to allogeneic hematopoietic stem cell transplantation, the current dogma is not an evidence of graft-versus-tumor effect in autologous hematopoietic stem cell transplantation; thus, it is assumed that autologous hematopoietic stem cell transplantation only relies on the high-dose chemotherapy to improve clinical outcomes. However, recent studies argue in favor of the existence of an autologous graft-versus-tumor without the detrimental complications of graft-versus-host disease due to the nonspecific immune response from the infused donor alloreactive immune effector cells in allogeneic hematopoietic stem cell transplantation. Herein, this paper reviews the clinical evidence of an autologous graft-versus-tumor effect based on the autograft collected and infused host immune effector cells and host immunity recovery after autologous hematopoietic stem cell transplantation affecting clinical outcomes in cancer patients. Read More

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http://dx.doi.org/10.1155/2016/5385972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011204PMC
September 2016
19 Reads

Haploidentical Family Donor Transplantation: At the Crossroads of a Changing Paradigm.

Adv Hematol 2016 2;2016:9753542. Epub 2016 Jun 2.

Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

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http://dx.doi.org/10.1155/2016/9753542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909892PMC
June 2016
11 Reads

Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies.

Adv Hematol 2016 30;2016:3905907. Epub 2016 May 30.

Department of Haematology, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK; Department of Haematology, Guys and St. Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.

Haematopoietic stem cell transplantation is a well-established treatment option for both hematological malignancies and nonmalignant conditions such as aplastic anemia and haemoglobinopathies. For those patients lacking a suitable matched sibling or matched unrelated donor, haploidentical donors are an alternative expedient donor pool. Historically, haploidentical transplantation led to high rates of graft rejection and GVHD. Read More

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http://dx.doi.org/10.1155/2016/3905907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904087PMC
June 2016
10 Reads

Clinical Scenarios for Discordant Anti-Xa.

Adv Hematol 2016 12;2016:4054806. Epub 2016 May 12.

Servicio de Gastrocirugía, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 06720 México, DF, Mexico.

Anti-Xa test measures the activity of heparin against the activity of activated coagulation factor X; significant variability of anti-Xa levels in common clinical scenarios has been observed. Objective. To review the most common clinical settings in which anti-Xa results can be bias. Read More

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http://dx.doi.org/10.1155/2016/4054806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880685PMC
June 2016
74 Reads
1 Citation

Combined Bone Marrow and Kidney Transplantation for the Induction of Specific Tolerance.

Adv Hematol 2016 30;2016:6471901. Epub 2016 Apr 30.

Bone Marrow Transplant Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

The induction of specific tolerance, in order to avoid the detrimental effects of lifelong systemic immunosuppressive therapy after organ transplantation, has been considered the "Holy Grail" of transplantation. Experimentally, tolerance has been achieved through clonal deletion, through costimulatory blockade, through the induction or infusion of regulatory T-cells, and through the establishment of hematopoietic chimerism following donor bone marrow transplantation. The focus of this review is how tolerance has been achieved following combined bone marrow and kidney transplantation. Read More

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http://dx.doi.org/10.1155/2016/6471901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867066PMC
May 2016
13 Reads

HLA Haplotype Mismatch Transplants and Posttransplant Cyclophosphamide.

Adv Hematol 2016 7;2016:7802967. Epub 2016 Apr 7.

Istituto di Ematologia, Universita' Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Gemelli, Rome, Italy.

The use of high dose posttransplant cyclophosphamide (PT-CY) introduced by the Baltimore group approximately 10 years ago has been rapidly adopted worldwide and is becoming a standard for patients undergoing unmanipulated haploidentical (HAPLO) transplants. PT-CY has been used following nonmyeloablative as well as myeloablative conditioning regimens, for bone marrow or peripheral blood grafts, for patients with malignant and nonmalignant disorders. Retrospective comparisons of HAPLO grafts with conventional sibling and unrelated donor grafts have been published and suggest comparable outcome. Read More

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http://dx.doi.org/10.1155/2016/7802967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838781PMC
May 2016
13 Reads

Choice of Unmanipulated T Cell Replete Graft for Haploidentical Stem Cell Transplant and Posttransplant Cyclophosphamide in Hematologic Malignancies in Adults: Peripheral Blood or Bone Marrow-Review of Published Literature.

Adv Hematol 2016 28;2016:6950346. Epub 2016 Mar 28.

Stem Cell Transplant Program, Henry Ford Hospital, Detroit, MI 48202, USA.

Allogeneic hematopoietic stem cell transplantation (SCT) is often the only curative option for many patients with malignant and benign hematological stem cell disorders. However, some issues are still of concern regarding finding a donor like shrinking family sizes in many societies, underrepresentation of the ethnic minorities in the registries, genetic variability for some races, and significant delays in obtaining stem cells after starting the search. So there is a considerable need to develop alternate donor stem cell sources. Read More

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http://dx.doi.org/10.1155/2016/6950346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826912PMC
April 2016
15 Reads

Retracted: Plasmablastic Lymphoma: A Review of Current Knowledge and Future Directions.

Adv Hematol 2016 24;2016:9742148. Epub 2016 Mar 24.

[This retracts the article DOI: 10.1155/2015/315289.]. Read More

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http://dx.doi.org/10.1155/2016/9742148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823591PMC
April 2016
10 Reads

Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues.

Adv Hematol 2016 24;2016:3467672. Epub 2016 Mar 24.

Department of Blood and Marrow Transplantation, Dharamshila Hospital and Research Centre, Vasundhara Enclave, New Delhi 110096, India; Manashi Chakrabarti Foundation, Kolkata, India.

Allogeneic hematopoietic stem cell transplantation (HSCT) remains a curative option for children with high risk and advanced acute leukemia. Yet availability of matched family donor limits its use and although matched unrelated donor or mismatched umbilical cord blood (UCB) are viable options, they fail to meet the global need. Haploidentical family donor is almost universally available and is emerging as the alternate donor of choice in adult patients. Read More

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http://dx.doi.org/10.1155/2016/3467672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823496PMC
April 2016
10 Reads

Review on Haploidentical Hematopoietic Cell Transplantation in Patients with Hematologic Malignancies.

Adv Hematol 2016 29;2016:5726132. Epub 2016 Feb 29.

Division of Hematology-Oncology, Bone Marrow Transplant Service, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USA.

Allogenic hematopoietic cell transplantation (HSCT) is typically the preferred curative therapy for adult patients with acute myeloid leukemia, but its use has been reduced as a consequence of limited donor availability in the form of either matched-related donors (MRD) or matched-unrelated donors (MUD). Alternative options such as unrelated umbilical cord blood (UCB) transplantation and haploidentical HSCT have been increasingly studied in the past few decades to overcome these obstacles. A human leukocyte antigen- (HLA-) haploidentical donor is a recipient's relative who shares an exact haplotype with the recipient but is mismatched for HLA genes on the unshared haplotype. Read More

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http://dx.doi.org/10.1155/2016/5726132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789357PMC
April 2016
10 Reads

Biochemical Markers of Bone Turnover in Patients with β-Thalassemia Major: A Single Center Study from Southern Pakistan.

Adv Hematol 2016 23;2016:5437609. Epub 2016 Feb 23.

Liaquat National Medical College, Karachi, Pakistan.

Objectives. Skeletal complications in β-homozygous thalassemic patients are uncommon but often debilitating, even amongst children and adolescent patients with well maintained transfusion and chelation therapy. The aim is to evaluate the biochemical markers of bone turnover in regularly transfused thalassemic patients and its possible correlations with demographic data and hematological and biochemical markers. Read More

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http://www.hindawi.com/journals/ah/2016/5437609/
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http://dx.doi.org/10.1155/2016/5437609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783526PMC
March 2016
38 Reads
1 Citation

Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph.

Adv Hematol 2016 21;2016:7678901. Epub 2016 Feb 21.

Biosciences Division, Emergent BioSolutions Incorporated, Winnipeg, MB, Canada R3T 5Y3; University of Manitoba, Winnipeg, MB, Canada R3T 2N2.

The goal of these studies was to extensively characterize the first recombinant FIX therapeutic corresponding to the threonine-148 (Thr-148) polymorph, IXINITY (trenonacog alfa [coagulation factor IX (recombinant)]). Gel electrophoresis, circular dichroism, and gel filtration were used to determine purity and confirm structure. Chromatographic and mass spectrometry techniques were used to identify and quantify posttranslational modifications. Read More

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http://dx.doi.org/10.1155/2016/7678901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779506PMC
March 2016
19 Reads

Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt.

Adv Hematol 2016 17;2016:9032627. Epub 2016 Feb 17.

Department of Clinical Pathology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.

Background. Frequent blood transfusions in thalassemia major children expose them to the risk of transfusion-transmitted infections (TTIs). The aim of this study was to estimate the prevalence of hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), and cytomegalovirus (CMV) in thalassemic children attending the Pediatrics Departments of both Sohag and Minia Universities of Upper Egypt, during the period from May 2014 to May 2015. Read More

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http://dx.doi.org/10.1155/2016/9032627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773519PMC
March 2016
21 Reads

Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana.

Adv Hematol 2016 15;2016:5368793. Epub 2016 Feb 15.

Department of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, Ghana.

The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Read More

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http://dx.doi.org/10.1155/2016/5368793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770114PMC
March 2016
15 Reads

Influence of Oxidative Stress on Stored Platelets.

Authors:
K Manasa R Vani

Adv Hematol 2016 2;2016:4091461. Epub 2016 Feb 2.

Department of Biotechnology, Center for Post Graduate Studies, Jain University, No. 18/3, 9th Main, 3rd Block, Jayanagar, Bangalore 560011, India.

Platelet storage and its availability for transfusion are limited to 5-6 days. Oxidative stress (OS) is one of the causes for reduced efficacy and shelf-life of platelets. The studies on platelet storage have focused on improving the storage conditions by altering platelet storage solutions, temperature, and materials. Read More

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http://dx.doi.org/10.1155/2016/4091461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754462PMC
March 2016
10 Reads

Haploidentical Hematopoietic Stem Cell Transplantation: Expanding the Horizon for Hematologic Disorders.

Adv Hematol 2016 2;2016:1423493. Epub 2016 Feb 2.

Division of Hematologic Malignancies and Cellular Therapy, Duke Cancer Institute, Durham, NC 27710, USA.

Despite the advent of targeted therapies and novel agents, allogeneic hematopoietic stem cell transplantation remains the only curative modality in the management of hematologic disorders. The necessity to find an HLA-matched related donor is a major obstacle that compromises the widespread application and development of this field. Matched unrelated donors and umbilical cord blood have emerged as alternative sources of donor stem cells; however, the cost of maintaining donor registries and cord blood banks is very high and even impractical in developing countries. Read More

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http://dx.doi.org/10.1155/2016/1423493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754478PMC
March 2016
27 Reads
2 Citations

Myeloablative Conditioning with PBSC Grafts for T Cell-Replete Haploidentical Donor Transplantation Using Posttransplant Cyclophosphamide.

Adv Hematol 2016 21;2016:9736564. Epub 2016 Jan 21.

Blood and Marrow Transplant Program at Northside Hospital, Atlanta, GA 30342, USA.

Relapse is the main cause of treatment failure after nonmyeloablative haploidentical transplant (haplo-HSCT). In an attempt to reduce relapse, we have developed a myeloablative (MA) haplo-HSCT approach utilizing posttransplant cyclophosphamide (PT/Cy) and peripheral blood stem cells as the stem cell source. We summarize the results of two consecutive clinical trials, using a busulfan-based (n = 20) and a TBI-based MA preparative regimen (n = 30), and analyze a larger cohort of 64 patients receiving MA haplo-HSCT. Read More

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http://dx.doi.org/10.1155/2016/9736564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745340PMC
February 2016
13 Reads

Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation.

Adv Hematol 2016 24;2016:4025073. Epub 2016 Jan 24.

Department of Stem Cell Transplant and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Outcomes of allogeneic hematopoietic stem cell transplantation (AHSCT) using HLA-half matched related donors (haploidentical) have recently improved due to better control of alloreactive reactions in both graft-versus-host and host-versus-graft directions. The recognition of the role of humoral rejection in the development of primary graft failure in this setting has broadened our understanding about causes of engraftment failure in these patients, helped us better select donors for patients in need of AHSCT, and developed rational therapeutic measures for HLA sensitized patients to prevent this unfortunate event, which is usually associated with a very high mortality rate. With these recent advances the rate of graft failure in haploidentical transplantation has decreased to less than 5%. Read More

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http://dx.doi.org/10.1155/2016/4025073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745275PMC
February 2016
10 Reads
3 Citations

Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls.

Adv Hematol 2015 31;2015:648349. Epub 2015 Dec 31.

Department of Radiology, PGIMER and Dr. RML Hospital, New Delhi 110001, India.

Chronic hemoglobinopathies like thalassemia are associated with many osteopathies like osteoporosis. Methods. This observational study was carried out to compare the bone mineral density (BMD) in transfusion dependent thalassemics with that of healthy controls. Read More

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http://dx.doi.org/10.1155/2015/648349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735999PMC
February 2016
10 Reads

Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias.

Adv Hematol 2015 30;2015:612567. Epub 2015 Dec 30.

Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.

BCR-ABL-mediated leukemias, either Chronic Myeloid Leukemia (CML) or Philadelphia positive Acute Lymphoblastic Leukemia (ALL), are the paradigm of targeted molecular therapy of cancer due to the impressive clinical responses obtained with BCR-ABL specific tyrosine kinase inhibitors (TKIs). However, BCR-ABL TKIs do not allow completely eradicating both CML and ALL. Furthermore, ALL therapy is associated with much worse responses to TKIs than those observed in CML. Read More

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http://dx.doi.org/10.1155/2015/612567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710905PMC
February 2016
13 Reads

Comparable Outcomes for Hematologic Malignancies after HLA-Haploidentical Transplantation with Posttransplantation Cyclophosphamide and HLA-Matched Transplantation.

Adv Hematol 2015 2;2015:431923. Epub 2015 Dec 2.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.

The implementation of high-dose posttransplantation cyclophosphamide (PTCy) has made HLA-haploidentical (haplo) blood or marrow transplantation (BMT) a cost effective and safe alternative donor transplantation technique, resulting in its increasing utilization over the last decade. We review the available retrospective comparisons of haplo BMT with PTCy and HLA-matched BMT in adults with hematologic malignancies. The examined studies demonstrate no difference between haplo BMT with PTCy and HLA-matched BMT with regard to acute graft-versus-host disease (aGVHD), nonrelapse mortality, and overall survival. Read More

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http://dx.doi.org/10.1155/2015/431923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680052PMC
December 2015
16 Reads

Real-World Assessment of Clinical Outcomes in Patients with Lower-Risk Myelofibrosis Receiving Treatment with Ruxolitinib.

Adv Hematol 2015 9;2015:848473. Epub 2015 Nov 9.

Novartis Pharma AG, 4056 Basel, Switzerland.

Few trial-based assessments of ruxolitinib in patients with lower-risk myelofibrosis (MF) have been conducted, and no studies have made such assessments in a real-world population. We assessed changes in spleen size and constitutional symptoms during ruxolitinib treatment using a retrospective, observational review of anonymized US medical record data of patients diagnosed with IPSS low-risk (n = 25) or intermediate-1-risk (n = 83) MF. The majority of patients were male (low risk, 60%; intermediate-1 risk, 69%). Read More

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http://dx.doi.org/10.1155/2015/848473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655278PMC
December 2015
12 Reads

Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study of Safety, Efficacy, and Cost-Effectiveness.

Adv Hematol 2015 4;2015:167029. Epub 2015 Nov 4.

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr. M. H. Mari Gowda Road, Hombegowda Nagar, Bangalore, Karnataka 560030, India.

Introduction. The incidence of Acute Myeloid Leukemia (AML) increases progressively with age and its treatment is challenging. This prospective case control study was undertaken to compare the safety, efficacy, and cost-effectiveness of decitabine with those of cytarabine in older patients with newly diagnosed AML who are not fit for intensive chemotherapy. Read More

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http://dx.doi.org/10.1155/2015/167029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649104PMC
November 2015
27 Reads

Profiling β Thalassemia Mutations in Consanguinity and Nonconsanguinity for Prenatal Screening and Awareness Programme.

Adv Hematol 2015 21;2015:625721. Epub 2015 Oct 21.

Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.

Mutation spectrum varies significantly in different parts and different ethnic groups of India. Social factors such as preference to marry within the community and among 1st degree relatives (consanguinity) play an important role in impeding the gene pool of the disease within the community and so in society by and large. The present paper discusses the role of consanguinity in profiling of beta thalassemia mutation, and thus the approach for prenatal screening and prevention based awareness programme. Read More

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http://dx.doi.org/10.1155/2015/625721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631845PMC
November 2015
23 Reads

The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria.

Adv Hematol 2015 15;2015:386451. Epub 2015 Oct 15.

Department of Family Medicine, Kwara State Specialist Hospital, Sobi, 240001 Ilorin, Nigeria.

Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in the world. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Read More

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http://dx.doi.org/10.1155/2015/386451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624881PMC
November 2015
15 Reads

Erythrocyte Catalase Activity in More Frequent Microcytic Hypochromic Anemia: Beta-Thalassemia Trait and Iron Deficiency Anemia.

Adv Hematol 2015 7;2015:343571. Epub 2015 Oct 7.

Instituto de Bioquímica Aplicada, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán (UNT), Balcarce 747, San Miguel de Tucumán, 4000 Tucumán, Argentina.

Most common microcytic hypochromic anemias are iron deficiency anemia (IDA) and β-thalassemia trait (BTT), in which oxidative stress (OxS) has an essential role. Catalase causes detoxification of H2O2 in cells, and it is an indispensable antioxidant enzyme. The study was designed to measure erythrocyte catalase activity (ECAT) in patients with IDA (10) or BTT (21), to relate it with thalassemia mutation type (β (0) or β (+)) and to compare it with normal subjects (67). Read More

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http://dx.doi.org/10.1155/2015/343571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615862PMC
November 2015
17 Reads

Determinants of Overall and Progression-Free Survival of Nigerian Patients with Philadelphia-Positive Chronic Myeloid Leukemia.

Adv Hematol 2015 7;2015:908708. Epub 2015 Sep 7.

Department of Hematology and Immunology, Obafemi Awolowo University, Ile-Ife 234-220005, Nigeria ; Department of Hematology and Blood Transfusion, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife 234-220005, Nigeria.

Objective. The tyrosine kinase inhibitors have markedly changed the disease course for patients with Ph(+) and/or BCR-ABL1 (+) chronic myeloid leukemia (CML). This study was embarked upon to assess the long-term effects of imatinib therapy on survival in adult Nigerian patients with CML. Read More

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http://dx.doi.org/10.1155/2015/908708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575984PMC
October 2015
20 Reads
1 Citation

Frequency of Red Cell Alloimmunization and Autoimmunization in Thalassemia Patients: A Report from Eastern India.

Adv Hematol 2015 6;2015:610931. Epub 2015 Sep 6.

Department of Immunohematology & Blood Transfusion, MCH, Kolkata 700073, India.

Introduction. Red blood cell (RBC) alloimmunization and autoimmunization remain a major problem in transfusion dependent thalassemic patients. There is a paucity of data on the incidence of RBC alloimmunization and autoimmunization in thalassemic patients from eastern part of India, as pretransfusion antibody screening is not routinely performed. Read More

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http://www.hindawi.com/journals/ah/2015/610931/
Publisher Site
http://dx.doi.org/10.1155/2015/610931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575732PMC
October 2015
24 Reads

Predictors of Outcome and Severity in Adult Filipino Patients with Febrile Neutropenia.

Adv Hematol 2015 3;2015:920838. Epub 2015 Sep 3.

Department of Medicine, Philippine General Hospital, Taft Avenue, Ermita, 1000 Manila, Philippines.

Aim. The study aimed to describe the profile of Filipino febrile neutropenia patients and to determine parameters associated with severe outcomes. Methods. Read More

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http://dx.doi.org/10.1155/2015/920838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573217PMC
September 2015
10 Reads