295 results match your criteria Advances in Hematology [Journal]


Assessment of Confirmed Clinical Hypersensitivity to Rituximab in Patients Affected with B-Cell Neoplasia.

Adv Hematol 2020 11;2020:4231561. Epub 2020 Jun 11.

Haematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Rituximab hypersensitivity reactions are rare but are one of the main causes of rituximab elimination from antilymphoma immunochemotherapy treatments. While the clinical picture may be indistinguishable from other infusion-related reactions, hypersensitivity reactions (HSR) do not disappear and instead become more intense with subsequent administrations. . Read More

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http://dx.doi.org/10.1155/2020/4231561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305539PMC

Blood Donors' Age, Haemoglobin Type, G6PD Status, and Blood Group Impact Storability of CPDA-1 Banked Whole Blood: A Repeated-Measure Cohort Study in Cape Coast, Ghana.

Adv Hematol 2020 30;2020:4959518. Epub 2020 May 30.

Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.

Background: The high prevalence of haemoglobin variants and glucose 6-phosphate dehydrogenase disorder (G6PDd) in sub-Saharan Africa means that substantial proportions of donor blood units carry these red cell abnormalities.

Aim: This study investigated the impact that inherited haemoglobin variants and/or G6PD status have on whole blood banked at 4-6°C for 35 days.

Method: This repeated-measure cohort study was undertaken on 103 donor blood units collected into blood bag containing CPDA-1 anticoagulant. Read More

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http://dx.doi.org/10.1155/2020/4959518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277056PMC

Efficacy and Safety of Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese.

Adv Hematol 2020 23;2020:3890706. Epub 2020 May 23.

Medstar Washington Hospital Center, Departments of Internal Medicine and Hematology and Oncology, Washington, DC, USA.

Obesity plays an essential role in the safety of pharmacologic drugs. There is paucity of data for direct oral anticoagulants (DOACs) in the obese, despite these agents becoming more widely used. The primary and secondary objectives of this study were to assess the safety and efficacy of DOACs in the overweight and obese populations when used for primary prophylaxis in the setting of non-valvular atrial fibrillation (NVAF) and for treatment of venous thromboembolisms (VTE). Read More

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http://dx.doi.org/10.1155/2020/3890706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262658PMC

Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients.

Adv Hematol 2020 20;2020:9545717. Epub 2020 May 20.

Hematology Unit, Clinical Pathology Department, Oncology Center Mansoura University (OCMU), Mansoura University, Mansoura, Egypt.

This study aimed to determine the clinical impact of CD25/CD123 coexpression in adult B-cell acute lymphoblastic leukemia (B-ALL) cases. One hundred and twenty newly diagnosed B-ALL patients (≤60 years old) were included in this study. CD123 and CD25 expression on leukemic blast cells were assessed using flow cytometry. Read More

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http://dx.doi.org/10.1155/2020/9545717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256740PMC

Blood Management and Risk Assessment for Transfusion in Pediatric Spinal Deformity Surgery.

Adv Hematol 2020 7;2020:8246309. Epub 2020 May 7.

Orthopedic Department, University Hospital of Santa Maria, Lisbon, Portugal.

Objectives: Evaluate the impact of a Quality and Safety Program (QSP) on the reduction of blood loss and transfusion needs in pediatric spinal deformity surgery, while defining risk factors for transfusion.

Background: Multimodal plan aiming to minimize transfusion needs has been shown to reduce transfusions and index rates in spinal deformity surgery. Anticipating blood loss and transfusion may help direct resources to patient needs or encourage reconsideration of the surgical plan. Read More

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http://dx.doi.org/10.1155/2020/8246309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229536PMC

Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course.

Adv Hematol 2020 12;2020:7696204. Epub 2020 May 12.

Department of Clinical Medicine and Therapeutics, University of Nairobi, Nairobi, Kenya.

Background: Imatinib mesylate is the gold standard for the treatment of all phases of Philadelphia-positive chronic myeloid leukemia. Patients on imatinib treatment may develop cytopenia due to drug toxicity. This study aimed to determine the types, grades, and time course of cytopenia in CML patients on imatinib at a Nairobi hospital. Read More

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http://dx.doi.org/10.1155/2020/7696204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240645PMC

Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study.

Adv Hematol 2020 21;2020:6710906. Epub 2020 Apr 21.

Dept. of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.

This retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters were assessed from the patients' records: initial blood parameters, blood parameters during initial chemotherapy, leukemia/therapy related complaints, duration of fever, microbiological findings (blood and urine), as well as patients' survival. Dental treatment need was defined as the presence of at least one carious tooth; periodontal treatment need was determined by the presence of probing depth ≥3. Read More

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http://dx.doi.org/10.1155/2020/6710906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191429PMC

Deletional Alpha-Thalassemia Alleles in Amazon Blood Donors.

Adv Hematol 2020 14;2020:4170259. Epub 2020 Apr 14.

Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas, Manaus, Amazonas, Brazil.

Alpha-thalassemia is highly prevalent in the plural society of Brazil and is a public health problem. There is limited knowledge on its accurate frequency and distribution in the Amazon region. Knowing the frequency of thalassemia and the prevalence of responsible mutations is, therefore, an important step in the understanding and control program. Read More

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http://dx.doi.org/10.1155/2020/4170259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178540PMC

Thrombophilic Risk of Factor V Leiden, Prothrombin G20210A, MTHFR, and Calreticulin Mutations in Essential Thrombocythemia Egyptian Patients.

Adv Hematol 2020 30;2020:7695129. Epub 2020 Mar 30.

Medical Oncology Unit, Oncology Center, Mansoura University, Faculty of Medicine, Mansoura, Egypt.

Objectives: Essential thrombocythemia (ET) is one of the myeloproliferative neoplasms characterized by a sustained elevation of platelet numbers with a tendency for thrombosis and hemorrhage. The aim of this work is to establish the relation between calreticulin, factor V Leiden, prothrombin G20210A, and MTHFR mutations in ET patients and the thrombotic risk of these patients.

Methods: This study was carried out on 120 ET patients and 40 apparently healthy individuals as a control group. Read More

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http://dx.doi.org/10.1155/2020/7695129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149341PMC

The Essential Thrombocythemia, Thrombotic Risk Stratification, and Cardiovascular Risk Factors.

Adv Hematol 2020 27;2020:9124821. Epub 2020 Mar 27.

Hematology Division University Hospital Policlinico "Paolo Giaccone", Via del Vespro 129, 90127 Palermo, Italy.

Essential thrombocythemia is a rare hematological malignancy with good overall survival, but moderate to high risk of developing arterial or venous thrombosis lifelong. Different thrombotic risk scores for patients with essential thrombocythemia have been proposed, but only one of them (the IPSET-t scoring system) takes into account the classical cardiovascular risk factors as one of the scoring items. Currently, in clinical practice, the presence of cardiovascular risk factors in patients with diagnosis of ET rarely determines the decision to initiate cytoreductive therapies. Read More

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http://dx.doi.org/10.1155/2020/9124821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139859PMC

Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon.

Adv Hematol 2020 17;2020:9864371. Epub 2020 Mar 17.

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaounde, Cameroon.

Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon. . Read More

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http://dx.doi.org/10.1155/2020/9864371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103039PMC

Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study.

Adv Hematol 2020 21;2020:7369731. Epub 2020 Mar 21.

Department of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.

Background: It is estimated that one out of every three Ghanaians has hemoglobin genotype mutation. This change in genetic make-up may result in genotypes such as HbAS, HbSS, and HbSC. Many children in low- and middle-income countries die even before they are diagnosed with sickle cell disease (SCD). Read More

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http://dx.doi.org/10.1155/2020/7369731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114737PMC

An Update on the Reversal of Non-Vitamin K Antagonist Oral Anticoagulants.

Adv Hematol 2020 27;2020:7636104. Epub 2020 Jan 27.

Division of Oncology and Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

Non-vitamin K antagonist oral anticoagulants (NOACs) include thrombin inhibitor dabigatran and coagulation factor Xa inhibitors rivaroxaban, apixaban, edoxaban, and betrixaban. NOACs have several benefits over warfarin, including faster time to the achieve effect, rapid onset of action, fewer documented food and drug interactions, lack of need for routine INR monitoring, and improved patient satisfaction. Local hemostatic measures, supportive care, and withholding the next NOAC dose are usually sufficient to achieve hemostasis among patients presenting with minor bleeding. Read More

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http://dx.doi.org/10.1155/2020/7636104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097770PMC
January 2020

Prevalence of Anemia and Its Associated Factors in Antiretroviral-Treated HIV/AIDS-Positive Adults from 2013 to 2018 at Debre Berhan Referral Hospital, Ethiopia.

Adv Hematol 2020 11;2020:2513578. Epub 2020 Mar 11.

Debre Berhan Referral Hospital, Debre Berhan, Ethiopia.

. Anemia was defined as a hemoglobin level of less than or equal to 13.9 g/dl for male and less than or equal to 12. Read More

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http://dx.doi.org/10.1155/2020/2513578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086413PMC

Laboratory Biomarkers, Cerebral Blood Flow Velocity, and Intellectual Function in Children with Sickle Cell Disease.

Adv Hematol 2020 26;2020:8181425. Epub 2020 Feb 26.

Section of Hematology, St. Christopher's Hospital for Children, Philadelphia, PA, USA.

Objective: The aim of this preliminary study was to describe putative markers of cerebral vasculopathy and investigate relationships among these markers, demographic factors, and cognitive function in a young sample of neurologically normal children with SCD. . Thirty-eight children with homozygous HbS, aged 4-11 years, were included. Read More

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http://dx.doi.org/10.1155/2020/8181425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061118PMC
February 2020

Serological Detection of Rh-Del Phenotype among Rh-Negative Blood Donors at National Blood Center, Yangon, Myanmar.

Adv Hematol 2020 18;2020:3482124. Epub 2020 Feb 18.

National Blood Center, Yangon 11131, Myanmar.

Background: Red cell Rhesus (Rh) antigen expression is influenced by the genetic polymorphism of and genes and reveals serologically different reactions of RhD variants such as partial D, weak D, and Rh-Del. Serologically, Rh-Del type can only be detected by an adsorption-elution technique, and it might be mistyped as Rh-negative. The prevalence of Rh-Del has not been reported yet in Myanmar. Read More

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http://dx.doi.org/10.1155/2020/3482124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049430PMC
February 2020

Haematological Profile of Adults with Malaria Parasitaemia Visiting the Volta Regional Hospital, Ghana.

Adv Hematol 2020 11;2020:9369758. Epub 2020 Feb 11.

Department of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.

Background: Malaria is known to cause severe health consequences due to its marked effects and alteration on the haematological parameters of infected individuals. This study evaluated the haematological profile of adult individuals infected with the malaria parasite.

Methods: A retrospective study was conducted using archived data of malaria positive cases from January 2017 to March 15, 2019. Read More

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http://dx.doi.org/10.1155/2020/9369758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036090PMC
February 2020

Effectiveness of Nurse Led Intervention on Health Related Quality of Life among Children with Sickle Cell Disease in Oman: A Pilot Study.

Adv Hematol 2019 28;2019:6045214. Epub 2019 Dec 28.

Lecturer, College of Nursing, Sultan Qaboos University, P. O. Box 66, Al Khoud, Muscat, Oman.

The children with Sickle Cell Disease (SCD) generally have poor Health Related Quality of Life (HRQOL). The study aimed to evaluate the effectiveness of nurse led intervention on HRQOL among children with SCD.

Methods: A total of 30 samples were selected using convenient sampling. Read More

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http://dx.doi.org/10.1155/2019/6045214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024092PMC
December 2019

Prognostic Impact of Lymphoid Enhancer Factor 1 Expression and Serum Galectin.3 in Egyptian AML Patients.

Adv Hematol 2019 18;2019:2352919. Epub 2019 Dec 18.

Hematology Unit, Clinical Pathology Department, Mansoura University, Egypt.

Background: Deregulation of the Wnt signaling pathway had a role in haematological malignancies. Previous studies reported that lymphoid enhancer factor 1 (LEF1) expression and serum Galectin-3 level could affect clinical parameters and outcome in acute myeloid leukemia patients, but as far as we know, no study has addressed their combined effect on AML patients.

Aim: We studied the expression of LEF1 by real-time qPCR and measured serum level of Gal. Read More

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http://dx.doi.org/10.1155/2019/2352919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935809PMC
December 2019

Prevalence of Anemia and Associated Factors among Newly Diagnosed Patients with Solid Malignancy at Tikur Anbessa Specialized Hospital, Radiotherapy Center, Addis Ababa, Ethiopia.

Adv Hematol 2019 20;2019:8279789. Epub 2019 Oct 20.

Addis Ababa University, Tikur Anbessa Specialized Hospital, Radiotherapy Center, Addis Ababa, Ethiopia.

Background: Anemia is a common finding in cancer, which is caused by many factors. It is a major cause of morbidity in cancer patients, worsens disease status and impairs treatment outcome; however, little is known about the prevalence of anemia and associated factors among cancer patients during diagnosis in developing countries like Ethiopia. In response to this, we have conducted research with the aim of assessing the prevalence of anemia and associated factors among newly diagnosed patients with solid malignancy at Tikur Anbessa Specialized Hospital (TASH), Radiotherapy center, Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.1155/2019/8279789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855075PMC
October 2019

Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine.

Adv Hematol 2019 12;2019:3295786. Epub 2019 Nov 12.

Department of Medical Lab Sciences, Faculty of Health Professions, Al-Quds University, Jerusalem, State of Palestine.

-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patients in northern governorates of Palestine. Read More

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http://dx.doi.org/10.1155/2019/3295786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875311PMC
November 2019

Coexistence of Myeloid and Lymphoid Neoplasms: A Single-Center Experience.

Adv Hematol 2019 3;2019:1486476. Epub 2019 Nov 3.

Second Department of Internal Medicine and Research Unit, Hematology Unit, University General Hospital "Attikon", 1 Rimini St. Haidari, 12462 Athens, Greece.

The coexistence of a myeloid and a lymphoid neoplasm in the same patient is a rare finding. We retrospectively searched the records of the Hematology Division of the Second Department of Internal Medicine and Research Institute at Attikon University General Hospital of Athens from 2003 to 2018. Nine cases have been identified in a total of 244 negative MPN and 25 MDS/MPN patients and 1062 LPD patients referred to our institution between 2003 and 2018. Read More

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http://dx.doi.org/10.1155/2019/1486476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875400PMC
November 2019

Management of Adult Patients with Primary Immune Thrombocytopenia (ITP) in Clinical Practice: A Consensus Approach of the Spanish ITP Expert Group.

Adv Hematol 2019 22;2019:4621416. Epub 2019 Aug 22.

Service of Hematology, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain.

Background And Objective: Diagnosis and management of primary immune thrombocytopenia (ITP) have changed dramatically in the last decade. The aim of the study was to obtain information about the opinion of the Spanish ITP Group (GEPTI) members regarding the best clinical practices for diagnosis and management of adult patients with ITP.

Materials And Methods: A two-round Delphi method was carried out by sending to 129 experts a 90-item questionnaire developed by 11 specialists, with a 4-point Likert scale ("never," "sometimes," "frequently," and "always") for the assessment of responses. Read More

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http://dx.doi.org/10.1155/2019/4621416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724426PMC
August 2019
8 Reads

Corrigendum to "Treatment of Febrile Neutropenia and Prophylaxis in Hematologic Malignancies: A Critical Review and Update".

Adv Hematol 2019;2019:4120631. Epub 2019 Jul 16.

Unidad de Medicina Interna, Sección de Enfermedades Infecciosas, Hospital Universitario Fundación Alcorcón, Calle Budapest 1, 28922 Madrid, Spain.

[This corrects the article DOI: 10.1155/2014/986938.]. Read More

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http://dx.doi.org/10.1155/2019/4120631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662276PMC
July 2019
2 Reads

Quantifying the Levels of Knowledge, Attitude, and Practice Associated with Sickle Cell Disease and Premarital Genetic Counseling in 350 Saudi Adults.

Adv Hematol 2019 2;2019:3961201. Epub 2019 May 2.

Division of Oncology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Our study aims to observe the levels of knowledge, attitude, and practice (KAP) associated with sickle cell disease (SCD) and premarital genetic counseling (PMGC) in 351 Saudi adults. The relationships between KAP levels and sociodemographic characteristics (age, gender, marital status, and educational level) were observed. The study was conducted in King Khalid University Hospital between February 21, 2017, and March 7, 2018. Read More

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http://dx.doi.org/10.1155/2019/3961201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521475PMC
May 2019
10 Reads

Lung Function Abnormalities in Sickle Cell Anaemia.

Adv Hematol 2019 1;2019:1783240. Epub 2019 Apr 1.

Department of Haematology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.

Background: Abnormalities in lung function tests have been shown to commonly occur in a majority of patients with sickle cell disease (SCD) even at steady state. The prevalence and pattern of these lung function abnormalities have been described in other populations but this is unknown among our sickle cell cohort. There is generally little information available on risk factors associated with the lung function abnormalities and its relevance in patient care. Read More

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http://dx.doi.org/10.1155/2019/1783240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463674PMC
April 2019
10 Reads

Loxoscelism: Cutaneous and Hematologic Manifestations.

Adv Hematol 2019 20;2019:4091278. Epub 2019 Mar 20.

Department of Hematology and Oncology, West Cancer Clinic, 7945 Wolf River Blvd, Germantown, TN 38138, USA.

Background: Brown recluse spider (BRS) envenomation can lead to significant morbidity through severe local reaction and systemic illness including acute hemolytic anemia, rhabdomyolysis, disseminated intravascular coagulopathy (DIC), and even death. We aim to describe the clinical features and the roles of antibiotics and steroids in the treatment of loxoscelism.

Methods: We retrospectively identified nine patients (pts) at our institution who were admitted with moderate to severe loxoscelism. Read More

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https://www.hindawi.com/journals/ah/2019/4091278/
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http://dx.doi.org/10.1155/2019/4091278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446102PMC
March 2019
15 Reads

Factors Associated with Anemia among People Living with HIV/AIDS Taking ART in Ethiopia.

Adv Hematol 2019 3;2019:9614205. Epub 2019 Mar 3.

School of Nursing and Midwifery, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Globally, anemia, among people living with HIV/AIDS, is a major public health problem. It has a significant effect on the progression of HIV/AIDS to advanced stages and there are a number of factors that often affect anemia. However, there is little insight regarding factors affecting anemia among HIV/AIDS patients in developing countries, including Ethiopia. Read More

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http://dx.doi.org/10.1155/2019/9614205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421011PMC
March 2019
5 Reads

Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia.

Adv Hematol 2019 3;2019:4397150. Epub 2019 Feb 3.

Graduate Programme in Development and Technological Innovation of Medicines, Federal University of Ceará, Fortaleza, Brazil.

Background: Sickle cell anaemia (SCA) is the most prevalent monogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, which modifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Read More

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http://dx.doi.org/10.1155/2019/4397150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378076PMC
February 2019
4 Reads

Real-World Treatment Patterns, Outcomes, and Healthcare Resource Utilization in Relapsed or Refractory Multiple Myeloma: Evidence from a Medical Record Review in France.

Adv Hematol 2019 29;2019:4625787. Epub 2019 Jan 29.

Department of Haematology, Hôpital Saint-Antoine, Sorbonne University, INSERM UMRs 938, EBMT Paris Study Office, CEREST-TC, Saint-Antoine Hospital, Paris, France.

Background: Limited data are available from real-world practices in Europe describing prevailing treatment patterns and outcomes in relapsed/refractory multiple myeloma (RRMM), particularly by cytogenetic risk.

Methods: A retrospective medical record review was conducted in 200 RRMM patients in France. From first relapse, patients were assessed on second-/third-line treatments, progression-free survival (PFS), overall survival (OS), and healthcare utilization. Read More

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http://dx.doi.org/10.1155/2019/4625787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374830PMC
January 2019
5 Reads

Effect of Imatinib on Bone Marrow Morphology and Angiogenesis in Chronic Myeloid Leukemia.

Adv Hematol 2019 1;2019:1835091. Epub 2019 Jan 1.

Department of Biostatistics & Health Informatics, Sanjay Gandhi Post Graduate of Medical Sciences, Raebareli Road, Lucknow, U.P. 226014, India.

Background And Objectives: Chronic myeloid leukemia (CML) is characterized by hyperproliferation of myeloid precursors, increased fibrosis, and neoangiogenesis in the bone marrow. Imatinib inhibits BCR-ABL tyrosine kinase produced due to reciprocal translocation t(9;22) in neoplastic CML cells. It reduces hyperproliferation of myeloid precursors and has been found to affect bone marrow fibrosis and angiogenesis. Read More

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https://www.hindawi.com/journals/ah/2019/1835091/
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http://dx.doi.org/10.1155/2019/1835091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332991PMC
January 2019
53 Reads

Traceability of Blood Transfusions and Reporting of Adverse Reactions in Developing Countries: A Six-Year Postpilot Phase Experience in Burkina Faso.

Adv Hematol 2018 20;2018:7938130. Epub 2018 Dec 20.

CHU UCL Namur asbl, 15 place L. Godin, 5000 Namur, Belgium.

Traceability is an essential tool for haemovigilance and transfusion safety. In Burkina Faso, the implementation of haemovigilance has been achieved as part of a pilot project from 2005 to 2009. Our study aims to evaluate the traceability of blood transfusions and reporting of adverse reactions over the 6-year postpilot phase. Read More

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http://dx.doi.org/10.1155/2018/7938130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317082PMC
December 2018
14 Reads

Burden of Sickle Cell Disease in Ghana: The Korle-Bu Experience.

Adv Hematol 2018 2;2018:6161270. Epub 2018 Dec 2.

Ghana Institute of Clinical Genetics, Korle-Bu, Accra, Ghana.

In Africa, sickle cell disease (SCD) is a major public health problem with over 200,000 babies born per year. In Ghana, approximately 15,000 (2%) of Ghanaian newborns are diagnosed with SCD annually. A retrospective review of medical records of all SCD patients aged 13 years and above, who presented to the sickle cell clinic at Ghana Institute of Clinical Genetics (GICG), Korle-Bu, from 1st January 2013 to 31st December 2014, was carried out, using a data abstraction instrument to document their phenotypes, demographics, attendance/clinic visits, pattern of attendance, and common complications seen. Read More

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https://www.hindawi.com/journals/ah/2018/6161270/
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http://dx.doi.org/10.1155/2018/6161270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304501PMC
December 2018
55 Reads

A Novel Approach for Objective Assessment of White Blood Cells Using Computational Vision Algorithms.

Adv Hematol 2018 13;2018:4716370. Epub 2018 Nov 13.

KINESTASIS Seedlings of Research, University of Cundinamarca, Fusagasugá, Colombia.

In the field of medicine, the analysis of blood is one of the most important exams to determine the physiological state of a patient. In the analysis of the blood sample, an important process is the counting and classification of white blood cells, which is done manually, being an exhaustive, subjective, and error-prone activity due to the physical fatigue that generates the professional because it is a method that consumes long laxes of time. The purpose of the research was to develop a system to identify and classify blood cells, by the implementation of the networks of Gaussian radial base functions (RBFN) for the extraction of its nucleus and subsequently their classification through the morphological characteristics, its color, and the distance between objects. Read More

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http://dx.doi.org/10.1155/2018/4716370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257897PMC
November 2018
8 Reads

The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes.

Adv Hematol 2018 1;2018:2458679. Epub 2018 Nov 1.

Medical University of Varna, Varna, Bulgaria.

Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by ineffective hematopoiesis and a wide spectrum of manifestations ranging from indolent and asymptomatic cytopenias to acute myeloid leukemia (AML). MDS result from genetic and epigenetic derangements in clonal cells and their surrounding microenvironments. Studies have shown associations between MDS and other autoimmune diseases. Read More

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http://dx.doi.org/10.1155/2018/2458679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241340PMC
November 2018
18 Reads

Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes.

Adv Hematol 2018 10;2018:8487403. Epub 2018 Oct 10.

Celgene International Holdings Corporation, 125047 Moscow, Russia.

We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease. Read More

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https://www.hindawi.com/journals/ah/2018/8487403/
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http://dx.doi.org/10.1155/2018/8487403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199869PMC
October 2018
31 Reads

Vitamin D and Nonskeletal Complications among Egyptian Sickle Cell Disease Patients.

Adv Hematol 2018 16;2018:3867283. Epub 2018 Sep 16.

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.

Lower levels of vitamin D have been documented in many patients with sickle cell disease (SCD), but data are still inconclusive regarding the association between vitamin D deficiency (VDD) and the occurrence or the severity of various SCD complications. Our study aimed to detect the prevalence of vitamin D deficiency among Egyptian patients with SCD and to associate it with the clinical course of the disease. We measured the level of 25-hydroxy vitamin D in 140 children (age from 4. Read More

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http://dx.doi.org/10.1155/2018/3867283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164208PMC
September 2018
12 Reads

Prevalence and Factors Associated with Anemia among Pregnant Women Attending Antenatal Clinic at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Adv Hematol 2018 29;2018:3942301. Epub 2018 Aug 29.

Department of Medical Laboratory Sciences, College of Health Science, Addis Ababa University, Ethiopia.

Background: In pregnancy, anemia is an important factor associated with an increased risk of maternal, fetal, and neonatal mortality, poor pregnancy outcomes, and impaired cognitive development, particularly in developing countries like Ethiopia. This study aimed to assess prevalence and factors associated with anemia among pregnant women attending antenatal clinic at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.1155/2018/3942301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136568PMC
August 2018
17 Reads

The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests.

Adv Hematol 2018 2;2018:6940152. Epub 2018 Jul 2.

Department of Pathology, Chettinad Health City and Research Institute, Kelambakkam, Chennai, Tamil Nadu, India.

Background: Automation helps improve laboratory operational efficiency and reduce the turnaround time. Pneumatic tube systems (PTS) automate specimen transport between the lab and other areas of the hospital. Its effect on complete blood count (CBC) and coagulation is still controversial. Read More

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http://dx.doi.org/10.1155/2018/6940152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051325PMC
July 2018
19 Reads

Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine.

Adv Hematol 2018 6;2018:5356245. Epub 2018 Jun 6.

Department of Medical Technology, Faculty of Allied Health Sciences, Arab American University in Jenin, State of Palestine.

Background: Transfusion of red blood cells (RBC) is an essential therapeutic tool in sickle cell disease (SCD). Repeated RBC transfusions can cause alloimmunization which causes difficulty in cross-matching and finding compatible blood for transfusions. This study aimed to investigate the frequency of RBC alloimmunization and related risk factors among Palestinian SCD patients. Read More

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http://dx.doi.org/10.1155/2018/5356245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011130PMC
June 2018
45 Reads

Prevalence of Bleeding Symptoms among Adolescents and Young Adults in the Capital City of Saudi Arabia.

Adv Hematol 2018 2;2018:1858241. Epub 2018 May 2.

Center of Excellence in Thrombosis and Hemostasis, King Saud University, Riyadh, Saudi Arabia.

Background: Bleeding disorders vary in prevalence. While some are rare, some can be common in both sexes. Most bleeding disorders manifest as chronic bleeding tendencies or as an increase in bleeding during surgical procedures or trauma. Read More

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https://www.hindawi.com/journals/ah/2018/1858241/
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http://dx.doi.org/10.1155/2018/1858241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954960PMC
May 2018
59 Reads

Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma.

Adv Hematol 2018 5;2018:3864398. Epub 2018 Mar 5.

Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Central Jakarta 10430, Indonesia.

Introduction: Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Read More

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http://dx.doi.org/10.1155/2018/3864398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859798PMC
March 2018
24 Reads

Impact of Age on Outcomes in Hospitalized Patients with Hereditary Hemorrhagic Telangiectasia.

Adv Hematol 2018 11;2018:4798425. Epub 2018 Feb 11.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Scottsdale, AZ, USA.

Background: There is little published literature regarding the impact of age on outcomes amongst hospitalized HHT (hereditary hemorrhagic telangiectasia) patients.

Methods: The Nationwide Inpatient Sample (NIS) was used to obtain data on all hospital discharges occurring in HHT patients from 2000 to 2012. The association between admission age and HHT-related complications and outcomes were studied. Read More

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http://dx.doi.org/10.1155/2018/4798425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828469PMC
February 2018
27 Reads

Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis.

Adv Hematol 2017 6;2017:7878605. Epub 2017 Dec 6.

Department of Pediatrics, University Hospital of Ioannina, Ioannina, Greece.

Immune thrombocytopenia (ITP) in children has a varied course and according to duration is distinguished as newly diagnosed (<3 months), persistent (3-12), and chronic (>12) types. Several studies have evaluated the prognostic factors for the progression of the disease, but similar works have yet to be performed in Greece. We aimed to identify prognostic markers for the three forms of the disease in 57 Greek children during a 13-year period. Read More

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http://dx.doi.org/10.1155/2017/7878605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736937PMC
December 2017
19 Reads

Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy.

Adv Hematol 2017 8;2017:8690416. Epub 2017 Nov 8.

Stem Cell Transplant Program, Henry Ford Hospital, 2799 W. Grand Blvd, Detroit, MI 48202, USA.

In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. We undertook a retrospective analysis of 78 patients with myeloid malignancies who received fludarabine and busulfan (FluBu4) with or without measuring Bu pharmacokinetics (Bu PK) and those who received busulfan with cyclophosphamide (BuCy). Fifty-five patients received FluBu4, of whom 21 had Bu PK measured, and 23 patients received BuCy. Read More

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http://dx.doi.org/10.1155/2017/8690416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698787PMC
November 2017
21 Reads

Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients.

Adv Hematol 2017 24;2017:6527306. Epub 2017 Oct 24.

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Improved therapies are urgently needed for patients with diffuse large B cell lymphoma (DLBCL). Success using immune checkpoint inhibitors and chimeric antigen receptor T cell technology has fuelled demand for validated cancer epitopes. Immunogenic cancer testis antigens (CTAs), with their widespread expression in many tumours but highly restricted normal tissue distribution, represent attractive immunotherapeutic targets that may improve treatment options for DLBCL and other malignancies. Read More

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http://dx.doi.org/10.1155/2017/6527306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674480PMC
October 2017
29 Reads

Study of Erythrocyte Indices, Erythrocyte Morphometric Indicators, and Oxygen-Binding Properties of Hemoglobin Hematoporphyrin Patients with Cardiovascular Diseases.

Adv Hematol 2017 17;2017:8964587. Epub 2017 Jul 17.

GBUZ RM "National Hospital for War Veterans", Saransk 430005, Russia.

The current study investigates the functional state of erythrocytes and indices of the oxygen-binding capacity of hemoglobin in blood samples from healthy donors and from patients with coronary artery disease and myocardial infarction before and after treatment. It has been established that, in cardiovascular diseases, erythrocyte morphology and hemoglobin oxygen-transporting disorders are observed. Standard therapy does not result in the restoration of the structure and properties of erythrocytes. Read More

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http://dx.doi.org/10.1155/2017/8964587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535697PMC
July 2017
44 Reads

Outcomes of Six-Dose High-Dose Cytarabine as a Salvage Regimen for Patients with Relapsed/Refractory Acute Myeloid Leukemia.

Adv Hematol 2017 14;2017:6464972. Epub 2017 May 14.

Department of Pharmacy, West Virginia University Medicine, Morgantown, WV, USA.

Relapsed/refractory acute myeloid leukemia (RR-AML) is associated with poor prognosis and long-term disease-free survival requires allogeneic hematopoietic cell transplantation (allo-HCT). Limited data exists, regarding the optimal regimen to obtain remission prior to allo-HCT. Single agent high-dose cytarabine (10-12 doses administered every 12 hours) has been previously used as induction therapy. Read More

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http://dx.doi.org/10.1155/2017/6464972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446853PMC
May 2017
84 Reads

Efficacy and Safety of Manual Partial Red Cell Exchange in the Management of Severe Complications of Sickle Cell Disease in a Developing Country.

Adv Hematol 2017 11;2017:3518402. Epub 2017 May 11.

Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal.

Introduction: The realization of red cell exchange (RCE) in Africa faces the lack of blood, transfusion safety, and equipment. We evaluated its efficacy and safety in severe complications of sickle cell disease.

Patients And Method: Manual partial RCE was performed among sickle cell patients who had severe complications. Read More

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https://www.hindawi.com/journals/ah/2017/3518402/
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http://dx.doi.org/10.1155/2017/3518402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443989PMC
May 2017
16 Reads

The Evolution of Prognostic Factors in Multiple Myeloma.

Adv Hematol 2017 21;2017:4812637. Epub 2017 Feb 21.

King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Multiple myeloma (MM) is a heterogeneous hematologic malignancy involving the proliferation of plasma cells derived by different genetic events contributing to the development, progression, and prognosis of this disease. Despite improvement in treatment strategies of MM over the last decade, the disease remains incurable. All efforts are currently focused on understanding the prognostic markers of the disease hoping to incorporate the new therapeutic modalities to convert the disease into curable one. Read More

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http://dx.doi.org/10.1155/2017/4812637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339490PMC
February 2017
43 Reads