223,286 results match your criteria Advances in Hematology [Journal]
Sportverletz Sportschaden 2018 Dec 11;32(4):243-250. Epub 2018 Dec 11.
Muscle Research Center Erlangen, Interdisciplinary Center for Muscle Research, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.
Delayed-onset muscle soreness (DOMS) is a type of ultrastructural muscle injury. The manifestation of DOMS is caused by eccentric or unfamiliar forms of exercise. Clinical signs include reduced force capacities, increased painful restriction of movement, stiffness, swelling, and dysfunction of adjacent joints. Read More
Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.
More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More
Curr Opin Biotechnol 2018 Dec 8;57:17-24. Epub 2018 Dec 8.
Department of Chemical and Biomolecular Engineering (BK Plus program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; Institute for the BioCentury, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea. Electronic address:
Corynebacterium glutamicum has been mainly used for industrial production of amino acids, and in recent years, it has also been successfully engineered to broaden its range of substrate and product profiles. In particular, C. glutamicum has been engineered to use non-natural sugar substrates (mainly pentoses) derived from hemicellulosic feedstock, which is the second abundant component of lignocellulosic biomass. Read More
Int J Radiat Oncol Biol Phys 2018 Dec 8. Epub 2018 Dec 8.
Department of Radiation Oncology, Keck School of Medicine of USC and Children's Hospital Los Angeles, Los Angeles, CA. Electronic address:
Purpose: We retrospectively assessed the incidence of cataracts in retinoblastoma (Rb) patients treated with either lens-sparing (LSRT) or whole-eye radiotherapy (WERT). A secondary aim of this study was to model the dose-response risk of cataract.
Methods: We reviewed 65 retinoblastoma patients treated with radiotherapy (RT) at XXXX from 1997-2015. Read More
Acta Biomater 2018 Dec 8. Epub 2018 Dec 8.
Department of Biomechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands.
Recent advances in additive manufacturing (AM) have enabled the fabrication of functionally graded porous biomaterials (FGPBs) for application as orthopedic implants and bone substitutes. Here, we present a step-wise topological design of FGPB based on diamond unit cells to mimic the structure of the femoral diaphysis. The FGPB was manufactured from Ti-6Al-4V powder using the selective laser melting (SLM) technique. Read More
Expert Opin Biol Ther 2018 Dec 11. Epub 2018 Dec 11.
d Marlene and Stewart Greenebaum Comprehensive Cancer Center , University of Maryland School of Medicine , Baltimore , Maryland.
Introduction: Head and neck squamous cell carcinomas (HNSCC) previously had limited treatment options once patients had progressed on systemic chemotherapy. With recent advances, immunotherapy now plays an important role in the treatment of advanced disease with improved outcomes as compared to cytotoxic chemotherapy. Areas covered: This article reviews the effects of the immune system and how it influences the development and response to HNSCC therapy. Read More
Dermatol Ther 2018 Dec 7:e12801. Epub 2018 Dec 7.
Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health.
The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. Read More
Bioessays 2018 Dec 11:e1800075. Epub 2018 Dec 11.
Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA.
The Liver kinase B1 with its downstream target AMP activated protein kinase (LKB1-AMPK), and the key nutrient sensor mammalian target of rapamycin complex 1 (mTORC1) form two signaling systems that coordinate metabolic and cellular activity with changes in the environment in order to preserve homeostasis. For example, nutritional fluctuations rapidly feed back on these signaling systems and thereby affect cell-specific functions. Recent studies have started to reveal important roles of these strategic metabolic regulators in Schwann cells for the trophic support and myelination of axons. Read More
Angew Chem Int Ed Engl 2018 Dec 7. Epub 2018 Dec 7.
Georgia Institute of Technology, School of Materials Science and Engineering, 771 Ferst Dr., NW, 3100K, Molecular Science & Engineering Bldg., 30332, Atlanta, UNITED STATES.
The past decade has witnessed rapid advances in graphitic carbon nitride (g-C3N4) as it is metal-free and affords highly stable hydrogen (H2) generation. Notably, density functional theory calculations show that C-substitution for N in g-C3N4 can increase Π-electron availability and in turn significantly increase the photocatalytic H2 generation. However, creating such C-incorporated g-C3N4 has proven challenging owing to the higher electronegativity of N over C. Read More
New Phytol 2018 Dec 7. Epub 2018 Dec 7.
Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
To deal with the ever-changing environment, sessile plants adapt diverse and plastic organ structures during postembryonic development. Among these, the apical hook forms shortly after seed germination of most dicots, protects the delicate shoot meristem from mechanical damage during soil emergence. For decades, this structure has been taken as an excellent model for investigating the mechanisms underlying differential growth of plant tissues. Read More
J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer stem cells (CSCs) are a small subpopulation of tumor cells that have been identified in most types of cancer. Features that distinguish them from the bulk of tumor cells include their pluripotency, self-renewal capacity, low proliferation rate, and tumor-initiating ability. CSCs are highly malignant, as they confer drug resistance and facilitate tumor progression, relapse, and metastasis. Read More
J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.
Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved in a range of intracellular processes. MTs play a role in cell division, beating of cilia and flagella, and intracellular transport. Over the past decades, much knowledge has been gained regarding MT function and structure, and its role in underlying disease progression. Read More
Reprod Domest Anim 2018 Dec 8. Epub 2018 Dec 8.
Laboratory of Reproductive Medicine and Molecular Endocrinology, Center of Translational Medicine - Scientific and Technological Bioresource Nucleus (CEMT-BIOREN).
In the pork industry, artificial insemination and the storage of boar semen in liquid at 17°C are routinely applied to optimize the ejaculate and bring about rapid genetic changes that are reflected in the animal protein. Although the results are satisfactory, they are below what occurs with natural mating. It is currently possible to preserve boar semen with storage at 17°C and slow freezing, since to date there is only one study on vitrification, with negative results applicable only in the case of implementing an intracytoplasmic sperm injection. Read More
Am J Hematol 2018 Dec 8. Epub 2018 Dec 8.
Dana Farber and Boston Children's Cancer and Blood Disorders Center, Boston, MA.
Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expanding genetic testing options for the evaluation of neutropenia have led to exciting advances but also new challenges. Read More
Adv Mater 2018 Dec 9:e1805230. Epub 2018 Dec 9.
Department of Chemical Engineering, Waterloo Institute for Nanotechnology, Waterloo Institute for Sustainable Energy, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.
Over the past decade, the surging interest for higher-energy-density, cheaper, and safer battery technology has spurred tremendous research efforts in the development of improved rechargeable zinc-air batteries. Current zinc-air batteries suffer from poor energy efficiency and cycle life, owing mainly to the poor rechargeability of zinc and air electrodes. To achieve high utilization and cyclability in the zinc anode, construction of conductive porous framework through elegant optimization strategies and adaptation of alternate active material are employed. Read More
Traffic 2018 Dec 7. Epub 2018 Dec 7.
Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI.
The trafficking of G protein coupled-receptors (GPCRs) is one of the most exciting areas in cell biology due to recent advances demonstrating that GPCR signaling is spatially encoded. GPCRs, acting in a diverse array of physiological systems, can have differential signaling consequences depending on their subcellular localization. At the plasma membrane, GPCR organization could fine-tune the initial stages of receptor signaling by determining the magnitude of signaling and the type of effectors to which receptors can couple. Read More
Adv Mater 2018 Dec 7:e1805092. Epub 2018 Dec 7.
Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Antibiotic-resistant bacteria have emerged as a severe threat to human health. As effective antibacterial therapies, supramolecular materials display unprecedented advantages because of the flexible and tunable nature of their noncovalent interactions with biomolecules and the ability to incorporate various active agents in their platforms. Herein, supramolecular antibacterial materials are discussed using a format that focuses on their fundamental active elements and on recent advances including material selection, fabrication methods, structural characterization, and activity performance. Read More
J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.
State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Stem cells are promising candidates for cell-based therapies in diverse conditions including regenerating damaged tissues, treating inflammation in virtue of sepsis, acute renal failure, and cardiovascular disease. Advancement of these therapies relies on the ability to guide stem cells to migrate directly and differentiate towards specific cell phenotypes. During the past decade, many researchers have demonstrated that exogenous applied forces could significantly affect the migration and lineage differentiation of stem cells. Read More
J Pharm Pharmacol 2019 Jan;71(1):1-3
Discipline of Pharmacology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.
Br J Haematol 2018 Dec 11. Epub 2018 Dec 11.
Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Hodgkin Lymphoma (HL) is a B-cell lymphoproliferative disorder with an excellent prognosis for the majority of patients who are treated with multi-agent chemotherapy, with or without radiation. A subset of patient, however, does not respond to therapy or relapses after accomplishing an initial response. Their outcome is poor and new treatment strategies are urgently needed for this patient population. Read More
J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
New perspectives have been opened by advances in stem cell research for reproductive and regenerative medicine. Several different cell types can be differentiated from stem cells (SCs) under suitable in vitro and in vivo conditions. The differentiation of SCs into male germ cells has been reported by many groups. Read More
Semin Liver Dis 2018 Dec 7. Epub 2018 Dec 7.
Department of Radiation Oncology, University of California San Francisco, San Francisco, California.
Hepatocellular carcinoma (HCC) is a complex and diverse disease, with choice of treatment dependent on a patient's disease burden, location of disease, underlying liver function, and performance status. While radiation therapy (RT) was historically omitted from treatment algorithms, immense technological advances over the past several decades have enabled introduction of RT as an effective and safe treatment option for patients with HCC. Growing prospective and retrospective evidence supports the use of RT, particularly stereotactic body radiotherapy (SBRT), for a wide range of indications in HCC from locally advanced unresectable disease to bridge therapy for liver transplant candidates. Read More
Breast Cancer Res Treat 2018 Dec 8. Epub 2018 Dec 8.
Department of Surgery, Brooklyn Breast Cancer Program of Maimonides Medical Center, 745 64th Street, Brooklyn, NY, 11220, USA.
Purpose: Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive ductal carcinoma. The authors sought to discuss the evidence suggesting that not all DCIS will progress to invasive disease if left untreated.
Results: Four lines of evidence align to suggest that not all of this in-situ disease progresses to invasive cancer: its prevalence on screening mammography, studies of missed diagnoses, incidental findings in autopsy specimens, and large retrospective reviews of those treated with excision alone. Read More
J Autism Dev Disord 2018 Dec 10. Epub 2018 Dec 10.
Developmental Disorders Program, Maine Behavioral Healthcare, 123 Andover Road, Westbrook, ME, 04092, USA.
Despite significant advances in autism research, experts have noted that children severely affected by autism spectrum disorder (ASD) appear to have been understudied. Rigorous analysis of this observation has been limited, and the representation of severity has not been well-described. We assessed three domains of severity (communication ability, cognitive functioning, and adaptive functioning) in 367 treatment studies of children with ASD published 1991-2013. Read More
Methods Mol Biol 2019 ;1905:167-174
Department of System Design Engineering, Keio University, Yokohama, Japan.
Construction of three-dimensional (3D) hepatic tissue structures is important for in vitro tissue engineering of the liver, because 3D culture of hepatocytes is critical for the maintenance of liver-specific functions. Although conventional 3D culture methods are useful for constructing 3D hepatic tissue structures, the precise control of culture microenvironments is required to construct more physiological tissues in vitro. Recent advances in microfluidics technologies have allowed us to utilize microfluidic devices for hepatic cell culture, which opened the door for creating more physiological 3D culture models of the liver. Read More
Methods Mol Biol 2019 ;1905:71-82
Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Recent technological advances have revealed the heterogeneity of cells and tissues. Existence of heterogeneity in hepatic progenitor cells is becoming apparent by various experimental approaches, and here we describe a series of techniques to investigate the proliferative heterogeneity of these cells. We have developed a new technique by combining genetic lineage tracking and three-dimensional imaging methods. Read More
Curr Med Sci 2018 Dec 7;38(6):949-961. Epub 2018 Dec 7.
Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Microbial constituents naturally inhabiting the gastrointestinal tract may influence the homeostasis of the gut environment. The presence or overabundance of some bacterial taxa has been reported to be associated with complex diseases, and the metabolites of certain bacteria may contribute to diverse disorders by influencing signaling pathways. Therefore, the study of gut microbial population has emerged as a crucial field and a new potential area of clinical significance. Read More
J Nucl Cardiol 2018 Dec 10. Epub 2018 Dec 10.
Department of Cardiology, Cornell University Medical Center, New York, USA.
Cardiac sarcoidosis and amyloidosis have gained recent attention due to substantial advances in imaging and management. In this issue of the Journal of Nuclear Cardiology, imaging experts discuss the role of microvascular perfusion, innervation, targeted imaging of the heart and whole body, and novel molecular targets for imaging inflammation, fibrosis, and amyloidosis. In addition to cutting edge science, experts provide, for the first time, a patient page with information for patients with sarcoidosis and amyloidosis. Read More
Surg Today 2018 Dec 7. Epub 2018 Dec 7.
Department of Cardiovascular Surgery, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-8072, Japan.
Purpose: This review summarizes the recent progress made in understanding the skill acquisition process of achieving expert status in various fields that require fine motor skills. We discuss the attempts to apply this progress to develop competent surgeons.
Methods: We reviewed the existing literature, using the keywords "surgical training", "skill acquisition", and "simulator-based training", using Medline, as well as recent books and chapters related to these issues. Read More
Int J Hematol 2018 Dec 7. Epub 2018 Dec 7.
Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan.
Recent advances in intensive chemo- and immunotherapy have contributed to the outcome of hemophagocytic lymphohistiocytosis (HLH); however, the prognosis of HLH in children differs by HLH subtype. In Japan, secondary HLH, particularly Epstein-Barr virus-associated HLH (EBV-HLH), is the most common HLH subtype. The prognosis of HLH has improved in recent years. Read More
Urolithiasis 2018 Dec 10. Epub 2018 Dec 10.
Mayo Clinic, Rochester, MN, USA.
Primary hyperoxaluria (PH) is caused by genetic mutations resulting in oxalate overproduction leading to nephrolithiasis, nephrocalcinosis, extrarenal manifestations, chronic kidney disease, and end-stage renal disease. Advances in genetic testing techniques have improved our ability to efficiently and effectively obtain a definitive diagnosis of PH as well as easily screen at-risk family members. Similarly, advances in technologies related to intervening at the genetic and molecular level promise to change the way we treat patients with PH. Read More
Cell Mol Life Sci 2018 Dec 8. Epub 2018 Dec 8.
Institut de Radioprotection et de Sureté Nucléaire (IRSN), PSE-SANTE, SESANE, LRTOX, B.P. no 17, 92262, Fontenay-aux-Roses Cedex, France.
This article reviews the current knowledge on the mechanisms of adaptive response to low doses of ionizing radiation or chemical exposure. A better knowledge of these mechanisms is needed to improve our understanding of health risks at low levels of environmental or occupational exposure and their involvement in cancer or non-cancer diseases. This response is orchestrated through a multifaceted cellular program involving the concerted action of diverse stress response pathways. Read More
Mil Med 2018 Dec 7. Epub 2018 Dec 7.
Psychological Health Center of Excellence, Defense Health Agency, 1335 East West Highway, Silver Spring, MD.
Introduction: Since the 1991 Gulf War, mental health conditions of military Service members have received increasing public attention and are a major focus for the U.S. government. Read More
Brief Bioinform 2018 Dec 10. Epub 2018 Dec 10.
Department of Healthcare Policy and Research, Weill Cornell Medicine at Cornell University, New York, NY, USA.
Owning to the rapid development of computer technologies, an increasing number of relational data have been emerging in modern biomedical research. Many network-based learning methods have been proposed to perform analysis on such data, which provide people a deep understanding of topology and knowledge behind the biomedical networks and benefit a lot of applications for human healthcare. However, most network-based methods suffer from high computational and space cost. Read More
Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.
Department of Paediatric Rheumatology, Alder Hey Children's Hospital, Liverpool, UK.
Objectives: The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care for children with rheumatic diseases. Systemic vasculitides are very rare in children. Consequently, despite recent advances, paediatric-specific information is sparse. Read More
J Speech Lang Hear Res 2018 Dec 10:1-10. Epub 2018 Dec 10.
Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL.
Purpose: Despite advances in cochlear implant and hearing aid technology, many children with hearing loss continue to exhibit poorer language skills than their hearing peers. This randomized pilot trial tested the effects of a parent-implemented communication treatment targeting prelinguistic communication skills in infants and toddlers with hearing loss.
Method: Participants included 19 children between 6 and 24 months of age with moderate to profound, bilateral hearing loss. Read More
Bioinformatics 2018 Dec 7. Epub 2018 Dec 7.
School of Information and Communication Technology, Griffith University, Gold Coast, Australia.
Motivation: Sequence-based prediction of one dimensional structural properties of proteins has been a long-standing subproblem of protein structure prediction. Recently, prediction accuracy has been significantly improved due to the rapid expansion of protein sequence and structure libraries and advances in deep learning techniques, such as residual convolutional networks (ResNets) and Long-Short-Term Memory Cells in Bidirectional Recurrent Neural Networks (LSTM-BRNNs). Here we leverage an ensemble of LSTM-BRNN and ResNet models, together with predicted residue-residue contact maps, to continue the push towards the attainable limit of prediction for 3- and 8-state secondary structure, backbone angles (θ, τ, ϕ, and ψ), half-sphere exposure, contact numbers, and solvent accessible surface area (ASA). Read More
Neurosurgery 2018 Dec 11. Epub 2018 Dec 11.
Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.
Radiation therapy (RT) plays a critical role in the overall management of many central nervous system (CNS) tumors. Advances in RT treatment planning, with techniques such as intensity modulated radiation therapy, volumetric modulated arc therapy, and stereotactic radiosurgery, now allow the delivery of highly conformal dose with great precision. These techniques rely on high-resolution 3-dimensional anatomical imaging modalities such as computed tomography or magnetic resonance imaging (MRI) scans to accurately and reliably define CNS targets and normal tissue avoidance structures. Read More
FEMS Microbiol Lett 2018 Dec 5. Epub 2018 Dec 5.
School of Natural Sciences, Bangor University, Bangor, LL57 2UW, United Kingdom.
A global census of marine microbial life has been underway for several decades. During this time there have been scientific breakthroughs in estimating microbial diversity and understanding microbial functioning and ecology. It is estimated that the ocean, covering 71% of the earth's surface with its estimated volume of about 2 × 1018 m3 and an average depth of 3800 m, hosts the largest population of microbes on Earth. Read More
Rev Med Chil 2018 Aug;146(8):921-926
Facultad de Psicología, Universidad de Talca, Talca, Chile.
Advances in cardiovascular diseases research have shown that there are differences in social groups, which have been solely explained by biomedical dimensions. Although there have been advances in the biological understanding of these diseases, they do not account for the complexity of the phenomenon. To address this, the introduction of psychosocial variables have shown that they may be useful to understand the manifestations and evolution of these conditions. Read More
Chem Soc Rev 2018 Dec 11. Epub 2018 Dec 11.
Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, China. and State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China and State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Nanozymes are nanomaterials with enzyme-like characteristics (Chem. Soc. Rev. Read More
Phys Chem Chem Phys 2018 Dec 10. Epub 2018 Dec 10.
School of Materials Sciences, Indian Association for the Cultivation of Science, Kolkata 700 032, India.
This feature article highlights the recent advances of luminescent metal nanoclusters (MNCs) for their potential applications in healthcare and energy-related materials because of their high photosensitivity, thermal stability, low toxicity, and biocompatibility. Current studies reveal that metal cluster based hybrid systems could pave the way for energy harvesting and sensing applications. To begin with, we illustrate general synthesis methodologies for atomically precise metal nanoclusters and discuss the origin of photoluminescence properties and the electronic transitions of nanoclusters. Read More
Int Symp Process Syst Eng 2018 2;44:2077-2082. Epub 2018 Aug 2.
Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Rapid detection and identification of process faults in industrial applications is crucial to sustain a safe and profitable operation. Today, the advances in sensor technologies have facilitated large amounts of chemical process data collection in real time which subsequently broadened the use of data-driven process monitoring techniques via machine learning and multivariate statistical analysis. One of the well-known machine learning techniques is Support Vector Machines (SVM) which allows the use of high dimensional feature sets for learning problems such as classification and regression. Read More
Commun Biol 2018 6;1:219. Epub 2018 Dec 6.
Joint Initiative for Metrology in Biology, 443 Via Ortega, Room 325, Stanford, CA 94305 USA.
Reproducing, exchanging, comparing, and building on each other's work is foundational to technological advances. Advancing biotechnology calls for reliable reuse of engineered organisms. Reliable reuse of engineered organisms requires reproducible growth and productivity. Read More
NPJ Precis Oncol 2018 4;2:27. Epub 2018 Dec 4.
Inova Neuroscience and Spine Institute, Inova Health Systems, Falls Church, VA USA.
The prognosis of glioblastoma has changed little over the past two decades, with only minor improvements in length of overall survival through the addition of temozolomide (temodal) to standard of care and the recommended use of alternating electric field therapy (optune) to newly diagnosed patients. In an effort to define novel therapeutic targets across molecularly heterogeneous disease subgroups, researchers have begun to uncover the complex interplay between epigenetics, cell signaling, metabolism, and the immunosuppressive tumor microenvironment. Indeed, IDH mutations are now recognized as a defining differential factor not only influencing global hypermethylation and patient prognosis but also degree of immune infiltration within individual tumors. Read More
Front Public Health 2018 26;6:348. Epub 2018 Nov 26.
Center for the Study of Aging, Boise State University, Boise, ID, United States.
Advances in the care and treatment of cystic fibrosis (CF) have led to improved mortality rates; therefore, considerably more individuals with CF are living into adulthood. With an increased number of CF patients advancing into adulthood, there is the need for more research that surrounds the aging adult CF patient. It is important to conduct research and collect results on the aging CF population to help better prepare the CF patient, who is dealing with the heavy treatment and financial burden of their disease, build autonomy and increase their quality of life. Read More
Front Immunol 2018 26;9:2741. Epub 2018 Nov 26.
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous system (CNS) and peripheral tissues. Leptin is secreted by adipose tissue and encoded by the obese () gene. Leptin acts as a central mediator which regulates immunity as well as nutrition. Read More
Front Immunol 2018 26;9:2716. Epub 2018 Nov 26.
Department of Molecular Biology and Genetics-Structural Biology, Aarhus University, Aarhus, Denmark.
Complement receptors (CR) 3 and 4 belong to the family of beta-2 (CD18) integrins. CR3 and CR4 are often co-expressed in the myeloid subsets of leukocytes, but they are also found in NK cells and activated T and B lymphocytes. The heterodimeric ectodomain undergoes considerable conformational change in order to switch the receptor from a structurally bent, ligand-binding in-active state into an extended, ligand-binding active state. Read More
Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):595-603. Epub 2018 Jun 15.
Department of Radiotherapy and Oncological Gynecology, Greater Poland Cancer Centre, Poznan, Poland.
Background: This article reviews the salient features of recent results of clinical studies. It puts a special emphasis on technical aspects, mechanisms of action together with radiotherapy and chemotherapy and points out areas for additional investigation.
Aim: To present the current state of knowledge on hyperthermia (HT) and to highlight its role in the treatment of cervical cancer. Read More