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    35101 results match your criteria Advances in Experimental Medicine and Biology [Journal]

    1 OF 703

    Methodological Implications and Repeatability of Nasal Nitric Oxide: Relevance for Challenge Studies.
    Adv Exp Med Biol 2018 Feb 22. Epub 2018 Feb 22.
    Institute for Prevention and Occupational Medicine (IPA) of the German Social Accident Insurance, Ruhr-University Bochum, Bochum, Germany.
    There is an interest in assessing changes in nasal NO (nNO) levels as an effect marker of upper airways. In this study, we examined methodologic influences on short and long term repeatability of nNO levels assessed by a portable electrochemical analyzer. Nine atopic and eighteen healthy subjects were exposed for 4 h to ethyl acrylate concentration of 0. Read More

    Embryonic Stem Cells in Development and Regenerative Medicine.
    Adv Exp Med Biol 2018 Feb 21. Epub 2018 Feb 21.
    National Cancer Instıtute, CDBL, NIH, Frederick, MD, USA.
    After progressive improvement in embryonic stem (ES) cell field, several studies have been conducted to explore the usage of ES cells in regenerative medicine. Unlimited self renewal and pluripoteny properties, combined with encouraging preclinical trials, remark that ES cell technology might be promising for clinical practice. ES cells, which can form three germ layers in vitro, are potential candidates to study development at the cellular and molecular level. Read More

    Hyperglycemia in Children Hospitalized with Acute Asthma.
    Adv Exp Med Biol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Hyperglycemia is frequently observed in adults with acute asthma. We aimed to assess the frequency of hyperglycemia and its relation to outcomes in children admitted with acute asthma. In this retrospective study, we reviewed medical records of non-diabetic 166 children (66 girls) with the mean age of 5. Read More

    SERPINA1 Gene Variants in Granulomatosis with Polyangiitis.
    Adv Exp Med Biol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Family Medicine, Internal and Metabolic Diseases, Warsaw Medical University, Warsaw, Poland.
    Alpha-1 antitrypsin (A1AT) deficiency is one of the most common genetic disorders in Caucasian population. There is a link between granulomatosis with polyangiitis (GPA) and most frequent variants of SERPINA1 gene encoding severe alpha-1 antitripsin deficiency. However, the potential effect of Pi*Z, Pi*S as well as other SERPINA1 variants on clinical course of vasculitis are not well understood. Read More

    Incidence and Drug Resistance of Zoonotic Mycobacterium bovis Infection in Peshawar, Pakistan.
    Adv Exp Med Biol 2018 Feb 17. Epub 2018 Feb 17.
    College of Animal Husbandry & Veterinary Sciences, Abdul Wali Khan University, Mardan, Pakistan.
    Prevalence of zoonotic Mycobacterium bovis (bTB) disease in human population is underreported from the North of Pakistan. Here, we report on the proportion of human bTB disease among the overall TB patients, drug resistance pattern of bTB isolates, and knowledge, attitude, and practices (KAP)-based analysis of bTB disease. For this purpose, sputum samples from a total of 300 clinically diagnosed TB patients and 100 randomly selected school children suspected of pulmonary TB were processed by culture as well as polymerase chain reaction (PCR) for isolation, identification, and confirmation of Mycobacterium tuberculosis (mTB) and bTB species. Read More

    Physical Training and Cardiac Rehabilitation in Heart Failure Patients.
    Adv Exp Med Biol 2018 Feb 17. Epub 2018 Feb 17.
    Department of Clinical and Experimental Medicine - Cardiology Unit, University Hospital Medical School "Gaetano Martino", Messina, Italy.
    Regardless of advances in medical and interventional treatment of cardiovascular disease (CVD), a limited number of patients attend a cardiac rehabilitation (CR) programme on a regular basis. Due to modern therapies more individuals will be surviving an acute cardiovascular event, but the expected burden of chronic heart failure will be increasing worldwide.However, both in high- and low-income countries, secondary prevention after an acute myocardial infarction or stroke has been implemented in less than a half of eligible patients. Read More

    Using of Quantum Dots in Biology and Medicine.
    Adv Exp Med Biol 2018 ;1048:323-334
    Lobachevsky Nizhny Novgorod State University, Nizhniy Novgorod, Russia.
    Quantum dots are nanoparticles, which due to their unique physical and chemical (first of all optical) properties, are promising in biology and medicine. There are many ways for quantum dots synthesis, both in the form of nanoislands self-forming on the surfaces, which can be used as single-photon emitters in electronics for storing information, and in the form of colloidal quantum dots for diagnostic and therapeutic purposes in living systems. The paper describes the main methods of quantum dots synthesis and summarizes medical and biological ways of their use. Read More

    A Drosophila Model to Decipher the Toxicity of Nanoparticles Taken Through Oral Routes.
    Adv Exp Med Biol 2018 ;1048:311-322
    Neural Developmental Biology Lab, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.
    In recent era, nanoparticles (NPs) are widely used in food, medicine and body implants. Besides it's wide use being a foreign particle it may have some noxious effect on the body. To understand the mechanistic role of NPs toxicity, Drosophila appeared to be a superior model organism. Read More

    Cytotoxicity and Physiological Effects of Silver Nanoparticles on Marine Invertebrates.
    Adv Exp Med Biol 2018 ;1048:285-309
    Institut de sciences de la mer de Rimouski (ISMER), Université du Québec à Rimouski, 310 Allée des Ursulines, Rimouski, QC, G5L 2Z9, Canada.
    Silver nanoparticles (AgNPs) incorporation in commercial products is increasing due to their remarkable physical and chemical properties and their low cost on the market. Silver has been known for a long time to be highly toxic to bacterial communities, aquatic organisms, and particularly to marine biota. Strong chloro-complexes dominate Ag speciation in seawater and facilitate its persistence in dissolved form. Read More

    Molecular and Cellular Toxicology of Nanomaterials with Related to Aquatic Organisms.
    Adv Exp Med Biol 2018 ;1048:263-284
    Division of Fish Genetics and Biotechnology, Central Institute of Fisheries Education, Mumbai, India.
    The increasing application of nanomaterials both in commercial and industrial products has led their accumulation in the aquatic ecosystem. The rapid development and large scale production of nanomaterials in the last few decades have stimulated concerns regarding their potential environmental health risks on aquatic biota. Inorganic nanoparticles, due to their unique properties and associated material characteristics resulted in toxicity of these nanomaterials in aquatic organisms. Read More

    Toxic and Beneficial Potential of Silver Nanoparticles: The Two Sides of the Same Coin.
    Adv Exp Med Biol 2018 ;1048:251-262
    Department of Genetics, Faculty of Medicine of Ribeirão Preto; USP, Ribeirão Preto, São Paulo, Brazil.
    Nanotechnology has allowed great changes in chemical, biological and physical properties of metals when compared to their bulk counterparts. Within this context, silver nanoparticles (AgNPs) play a major role due to their unique properties, being widely used in daily products such as fabrics, washing machines, water filters, food and medicine. However, AgNPs can enter cells inducing a "Trojan-horse" type mechanism which potentially leads to cellular autophagy, apoptosis or necrosis. Read More

    Mechanisms Underlying Neurotoxicity of Silver Nanoparticles.
    Adv Exp Med Biol 2018 ;1048:227-250
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
    The potent antimicrobial properties of nanoparticulate silver (AgNPs) have led to broad interest in using them in a wide range of commercial and medical applications. Although numerous in vivo and in vitro studies have provided evidence of toxic effects, rapid commercialization of AgNP-based nanomaterials has advanced without characterization of their potential environmental and health hazards. There is evidence that AgNPs can be translocated from the blood to the brain, regardless the route of exposure, and accumulate in the brain over time. Read More

    Detection of DNA Damage Induced by Cerium Dioxide Nanoparticles: From Models to Molecular Mechanism Activated.
    Adv Exp Med Biol 2018 ;1048:215-226
    Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto; USP, Ribeirão Preto, São Paulo, Brazil.
    This chapter will present an original effort to summarize the relevant data about the cyto-genotoxicity induced by cerium dioxide nanoparticles (nanoceria) in physiologically (in vivo and in vitro) relevant models. In this way, this chapter should be extremely useful to everyone who wants to plan their research and publishing their results. Massive application of nanoceria at different fields is increasing year after year, and it is urgent to address and discuss their use and its safety-related issues. Read More

    Cellular and Molecular Toxicity of Iron Oxide Nanoparticles.
    Adv Exp Med Biol 2018 ;1048:199-213
    Department of Psychology, Area of Psychobiology, Universidade da Coruña, DICOMOSA Group, A Coruña, Spain.
    Iron oxide nanoparticles (ION) have attracted much attention because of their particular physico-chemical properties, including superparamagnetism. These features make them suitable for many purposes and several interesting biomedical applications, such as to increase contrast in magnetic resonance imaging (MRI), as drug delivery systems and as hyperthermia agents. However, they have also shown to be easily accumulated in diverse tissues and induce toxicity at different levels. Read More

    Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona.
    Adv Exp Med Biol 2018 ;1048:175-198
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
    The physico-chemical properties of nanoparticles, as characterized under idealized laboratory conditions, have been suggested to differ significantly when studied under complex physiological environments. A major reason for this variation has been the adsorption of biomolecules (mainly proteins) on the nanoparticle surface, constituting the so-called "biomolecular corona". The formation of biomolecular corona on the nanoparticle surface has been reported to influence various nanoparticle properties viz. Read More

    Nickel Oxide Nanoparticles Induced Transcriptomic Alterations in HEPG2 Cells.
    Adv Exp Med Biol 2018 ;1048:163-174
    Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
    Nickel oxide nanoparticles (NiO-NPs) are increasingly used and concerns have been raised on its toxicity. Although a few studies have reported the toxicity of NiO-NPs, a comprehensive understanding of NiO-NPs toxicity in human cells is still lagging. In this study, we integrated transcriptomic approach and genotoxic evidence to depict the mechanism of NiO-NPs toxicity in human hepatocellular carcinoma (HepG2) cells. Read More

    Toxicogenomics: A New Paradigm for Nanotoxicity Evaluation.
    Adv Exp Med Biol 2018 ;1048:143-161
    Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
    The wider applications of nanoparticles (NPs) has evoked a world-wide concern due to their possible risk of toxicity in humans and other organisms. Aggregation and accumulation of NPs into cell leads to their interaction with biological macromolecules including proteins, nucleic acids and cellular organelles, which eventually induce toxicological effects. Application of toxicogenomics to investigate molecular pathway-based toxicological consequences has opened new vistas in nanotoxicology research. Read More

    Relevance of Physicochemical Characterization of Nanomaterials for Understanding Nano-cellular Interactions.
    Adv Exp Med Biol 2018 ;1048:123-142
    Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Lisbon, Portugal.
    The manufactured nanomaterials (NMs) have specific physicochemical properties that confer unique mechanical, optical, electrical and magnetic characteristics that are beneficial for biomedical and industrial applications. However, recent studies have suggested that such specific physicochemical properties of the NMs may define nano-bio interactions thereby determining their toxic potential.One of the major concerns about NMs is the potential to induce cancer, suggested by some experimental studies, as seen for titanium dioxide nanomaterials or carbon nanotubes. Read More

    Toxicity of Metal Oxide Nanoparticles.
    Adv Exp Med Biol 2018 ;1048:99-122
    Department of Medical Bionanotechnology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Rajiv Gandhi Salai, Kelambakkam, Kanchipuram, Tamil Nadu, India.
    In the recent times, nanomaterials are used in many sectors of science, medicine and industry, without revealing its toxic effects. Thus, it is in urgent need for exploring the toxicity along with the application of such useful nanomaterials. Nanomaterials are categorized with a particle size of 1-100 nm. Read More

    Nanoparticles-Caused Oxidative Imbalance.
    Adv Exp Med Biol 2018 ;1048:85-98
    Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
    Application of nanomaterials in nearly every single branch of industry results in their accumulation in both abiotic environment and tissues of living organisms. Despite the common use of nanomaterials, we are not able to precisely define their toxicity towards humans and surrounding biota. Although we were able to determine final effects of chronic exposure to nanoparticles which consist of many pathologies such as respiratory diseases, allergies, diseases of cardiovascular system, disorders in embryonic life differentiation and growth disorders, toxic effects on the immune system and cancers. Read More

    The Role of Autophagy in Nanoparticles-Induced Toxicity and Its Related Cellular and Molecular Mechanisms.
    Adv Exp Med Biol 2018 ;1048:71-84
    Department of Microbiological and Biochemical Pharmacy & The Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
    In the past decades, nanoparticles have been widely used in industry and pharmaceutical fields for drug delivery, anti-pathogen, and diagnostic imaging purposes because of their unique physicochemical characteristics such as special ultrastructure, dispersity, and effective cellular uptake properties. But the nanotoxicity has been raised over the extensive applications of nanoparticles. Researchers have elucidated series of mechanisms in nanoparticles-induced toxicity, including apoptosis, necrosis, oxidative stress, and autophagy. Read More

    The Toxicity of Nanoparticles to Human Endothelial Cells.
    Adv Exp Med Biol 2018 ;1048:59-69
    Key Laboratory of Environment-Friendly Chemistry and Applications of Ministry Education, Laboratory of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan, People's Republic of China.
    The use of nanoparticles (NPs) in commercially available products and as biomedicinal materials could lead to increasing contact of human blood vessels with NPs, and it is necessary to assess the potential adverse effects of NPs to cells lining blood vessels. Of them, endothelial cells (ECs) are of particular relevance as they play a crucial role in the regulation of function of blood vessels. In this book chapter, I discussed studies that used human ECs to study the toxicity and mechanisms of NPs. Read More

    Transmucosal Nanoparticles: Toxicological Overview.
    Adv Exp Med Biol 2018 ;1048:37-57
    Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.
    Nanoparticles have specific physicochemical properties different to bulk materials of the same composition and such properties make them very attractive for commercial and medical applications. Mucoadhesive nanoparticulate dosage forms are designed to enable prolonged retention of these nanoparticles at the site of application, providing a controlled drug release for improved therapeutic outcome. Moreover, drug delivery across the mucosa bypasses the first-pass hepatic metabolism and avoids the degradation by gastrointestinal enzymes. Read More

    Mechanisms of Uptake and Translocation of Nanomaterials in the Lung.
    Adv Exp Med Biol 2018 ;1048:21-36
    CNRS UMR 8251, Unit of Functional and Adaptive Biology (BFA), Laboratory of Molecular and Cellular Responses to Xenobiotics, University Paris Diderot (Sorbonne Paris Cité), Paris, France.
    Nanomaterials are invading our environment due to their increasing use in a very broad range of sectors making human exposure foreseeable during the life cycle of these materials. Inhalation is one of the most frequent routes of exposure in case of unintentional exposure and the small size of nanomaterials allows them to reach the deep lung. Understanding the fate and effects of nanomaterials is a great challenge for scientists as they exhibit a huge physico-chemical diversity that drives their biological reactivity. Read More

    Toxicity Assessment in the Nanoparticle Era.
    Adv Exp Med Biol 2018 ;1048:1-19
    Dipartimento di Matematica e Fisica "Ennio De Giorgi", Università del Salento, Lecce, Italy.
    The wide use of engineered nanomaterials in many fields, ranging from biomedical, agriculture, environment, cosmetic, urged the scientific community to understand the processes behind their potential toxicity, in order to develop new strategies for human safety. As a matter of fact, there is a big discrepancy between the increased classes of nanoparticles and the consequent applications versus their toxicity assessment. Nanotoxicology is defined as the science that studies the effects of engineered nanodevices and nanostructures in living organisms. Read More

    Baker's Asthma: Is the Ratio of Rye Flour-Specific IgE to Total IgE More Suitable to Predict the Outcome of Challenge Test Than Specific IgE Alone.
    Adv Exp Med Biol 2018 Feb 15. Epub 2018 Feb 15.
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University (IPA), Bochum, Germany.
    Usually the diagnosis of baker's asthma is based on specific inhalation challenge with flours. To a certain extent the concentration of specific IgE to flour predicts the outcome of challenge test in bakers. The aim of this study was to evaluate whether the ratio of specific IgE (sIgE) to total IgE (tIgE) improves challenge test prediction in comparison to sIgE alone. Read More

    Long-Term Exposure to Ambient Air Pollution in Childhood-Adolescence and Lung Function in Adulthood.
    Adv Exp Med Biol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Anthropology, Institute of Zoology, Jagiellonian University, Cracow, Poland.
    The aim of the study was to evaluate the effect of air pollution in the dwelling place during childhood-adolescence on respiratory function in early adulthood. The study was conducted in 220 female and 160 male university undergraduates in the cities of Cracow and Wroclaw in Poland and consisted of spirometry to assess lung function. The subjects' exposure to pollution during childhood-adolescence was assessed from the data acquired by the Polish Chief Inspectorate for Environmental Protection. Read More

    Estimation of Posturographic Trajectory Using k-Nearest Neighbors Classifier in Patients with Rheumatoid Arthritis and Osteoarthritis.
    Adv Exp Med Biol 2018 Feb 15. Epub 2018 Feb 15.
    Rehabilitation Clinic, Professor E. Reicher National Institute Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland.
    Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic diseases and account for a significant percentage of disability. Posturography is a method that assesses postural stability and quantitatively evaluates postural sways. The objective of this study was to estimate posturographic trajectories applying pattern recognition algorithms. Read More

    Role of Zic Family Proteins in Transcriptional Regulation and Chromatin Remodeling.
    Adv Exp Med Biol 2018 ;1046:353-380
    Department of Medical Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Proper functions of Zic proteins are essential for animals in health and disease. Here, we summarize our current understanding of the molecular properties and functions of the Zic family across animal species and paralog subtypes. Zics are basic proteins with some posttranslational modifications and can move to the cell nucleus via importin- and CRM1-based nucleocytoplasmic shuttling mechanisms. Read More

    Roles of ZIC2 in Regulation of Pluripotent Stem Cells.
    Adv Exp Med Biol 2018 ;1046:339-351
    Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan.
    Pioneered by the classical mouse embryonic stem cells (ESCs), various stem cell lines representing the peri- and postimplantation stages of embryogenesis have been established. To gain insight into the gene regulatory network operating in these cells, we first investigated epiblast stem cells (EpiSCs), performing ChIP-seq analysis for five major transcription factors (TFs) involved in epiblast regulation. The analysis indicated that SOX2-POU5F1 TF pairs highlighted in mouse ESCs are not the major players in other stem cells. Read More

    Deregulation of ZIC Family Members in Oncogenesis.
    Adv Exp Med Biol 2018 ;1046:329-338
    Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.
    In the last decade, the amount of investigations on the involvement of ZIC genes in the cancer field have exponentially expanded. In most cancer types, promoter methylation leads to silenced ZIC family members, but specific subsets of patients clearly show increased expression of one or head-to-head located ZIC genes in the respective tumor tissue. It is unclear at this stage how these transcription factors contribute to tumorigenesis, but the potential implications in pathways that are most frequently mutated in cancer such as the canonical Wnt, TGF-beta, and STAT-3 pathway are evident. Read More

    ZIC3 in Heterotaxy.
    Adv Exp Med Biol 2018 ;1046:301-327
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
    Mutation of ZIC3 causes X-linked heterotaxy, a syndrome in which the laterality of internal organs is disrupted. Analysis of model organisms and gene expression during early development suggests ZIC3-related heterotaxy occurs due to defects at the earliest stage of left-right axis formation. Although there are data to support abnormalities of the node and cilia as underlying causes, it is unclear at the molecular level why loss of ZIC3 function causes such these defects. Read More

    ZIC2 in Holoprosencephaly.
    Adv Exp Med Biol 2018 ;1046:269-299
    Early Mammalian Development Laboratory, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
    The ZIC2 transcription factor is one of the most commonly mutated genes in Holoprosencephaly (HPE) probands. HPE is a severe congenital defect of forebrain development which occurs when the cerebral hemispheres fail to separate during the early stages of organogenesis and is typically associated with mispatterning of the embryonic midline. Recent study of genotype-phenotype correlations in HPE cases has defined distinctive features of ZIC2-associated HPE presentation and genetics, revealing that ZIC2 mutation does not produce the craniofacial abnormalities generally thought to characterise HPE but leads to a range of non-forebrain phenotypes. Read More

    ZIC1 Function in Normal Cerebellar Development and Human Developmental Pathology.
    Adv Exp Med Biol 2018 ;1046:249-268
    Department of Pediatrics, University of Washington School of Medicine, Seattle Children's Hospital Research Institute, Center for Integrative Brain Research, Seattle, WA, USA.
    Zic genes are strongly expressed in the cerebellum. This feature leads to their initial identification and their name "zic," as the abbreviation of "zinc finger protein of the cerebellum." Zic gene function in cerebellar development has been investigated mainly in mice. Read More

    Zic Family Proteins in Emerging Biomedical Studies.
    Adv Exp Med Biol 2018 ;1046:233-248
    Department of Medical Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Zic family proteins have been investigated in various biomedical studies. Here we summarize the contact points between Zic proteins and recent medical research. The topics cover a wide range, reflecting the pleiotropic roles of these proteins in early embryogenesis and organogenesis. Read More

    Rodent Zic Genes in Neural Network Wiring.
    Adv Exp Med Biol 2018 ;1046:209-230
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández, CSIC-UMH, Alicante, Spain.
    The formation of the nervous system is a multistep process that yields a mature brain. Failure in any of the steps of this process may cause brain malfunction. In the early stages of embryonic development, neural progenitors quickly proliferate and then, at a specific moment, differentiate into neurons or glia. Read More

    Overview of Rodent Zic Genes.
    Adv Exp Med Biol 2018 ;1046:179-207
    Early Mammalian Development Laboratory, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
    The five murine Zic genes encode multifunctional transcriptional regulator proteins important for a large number of processes during embryonic development. The genes and proteins are highly conserved with respect to the orthologous human genes, an attribute evidently mirrored by functional conservation, since the murine and human genes mutate to give the same phenotypes. Each ZIC protein contains a zinc finger domain that participates in both protein-DNA and protein-protein interactions. Read More

    Zebrafish Zic Genes Mediate Developmental Signaling.
    Adv Exp Med Biol 2018 ;1046:157-177
    International Institute of Molecular and Cell Biology, Warsaw, Poland.
    The introduction of genomics into the field of developmental biology led to a vast expansion of knowledge about developmental genes and signaling mechanisms they are involved in. Unlike mammals, the zebrafish features seven Zic genes. This provides an interesting insight into Zic gene evolution. Read More

    Zic Genes in Teleosts: Their Roles in Dorsoventral Patterning in the Somite.
    Adv Exp Med Biol 2018 ;1046:141-156
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.
    The medaka contains seven zic genes, two of which, zic1 and zic4, have been studied extensively. The analyses are mainly based on the double anal fin (Da) mutant, which was isolated from the wild. Da is an enhancer mutant of zic1/zic4, and the expression of zic1/zic4 is specifically lost in the dorsal half of the somites, which leads to a mirror-image duplication of the ventral half across the lateral midline from larva to adult. Read More

    Amphibian Zic Genes.
    Adv Exp Med Biol 2018 ;1046:107-140
    Department of Cell Biology and Neuroscience, Montana State University, Bozeman, MT, USA.
    Studies in Xenopus laevis have greatly contributed to understanding the roles that the Zic family of zinc finger transcription factors play as essential drivers of early development. Explant systems that are not readily available in other organisms give Xenopus embryos a unique place in these studies, facilitated by the recent sequencing of the Xenopus laevis genome. A number of upstream regulators of zic gene expression have been identified, such as inhibition of BMP signaling, as well as calcium, FGF, and canonical Wnt signaling. Read More

    Lophotrochozoan Zic Genes.
    Adv Exp Med Biol 2018 ;1046:69-86
    Department of Medical Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Lophotrochozoa is a sister taxon of Ecdysozoa in the Protostomia that includes mollusks, annelids, brachiopods, and platyhelminths. Recent studies have clarified the structure, expression, and roles of lophotrochozoan Zic family genes. Zic genes in oligochaete annelid Tubifex tubifex (freshwater sludge worm) and polychaete annelid Capitella teleta (bristle worm) are commonly expressed in a subset of developing brain and mesoderm derivatives. Read More

    Zic Genes in Nematodes: A Role in Nervous System Development and Wnt Signaling.
    Adv Exp Med Biol 2018 ;1046:59-68
    Aix-Marseille Université, CNRS, Institut de Biologie du Développement de Marseille, Marseille, France.
    Transcription factors of the Zic family play important roles during animal development, and their misregulation has been implicated in several human diseases. Zic proteins are present in nematodes, and their function has been mostly studied in the model organism C. elegans. Read More

    Odd-Paired: The Drosophila Zic Gene.
    Adv Exp Med Biol 2018 ;1046:41-58
    Division of Cell and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
    Zinc finger in the cerebellum (Zic) proteins are a family of transcription factors with multiple roles during development, particularly in neural tissues. The founding member of the Zic family is the Drosophila odd-paired (opa) gene. The Opa protein has a DNA binding domain containing five Cys2His2-type zinc fingers and has been shown to act as a sequence-specific DNA binding protein. Read More

    Cnidarian Zic Genes.
    Adv Exp Med Biol 2018 ;1046:27-39
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA.
    To understand the ancestral and evolved roles of zic homologs, it is important to reconstruct the putative roles of ancient zic homologs in the animal phylogeny. Most studies of zic genes have been conducted in model systems that are members of the bilaterian phylum. However, two additional phyla have zic homologs encoded in their genomes. Read More

    Comparative Genomics of the Zic Family Genes.
    Adv Exp Med Biol 2018 ;1046:3-26
    Department of Medical Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Zic family genes encode five C2H2-type zinc finger domain-containing proteins that have many roles in animal development and maintenance. Recent phylogenetic analyses showed that Zic family genes are distributed in metazoans (multicellular animals), except Porifera (sponges) and Ctenophora (comb jellies). The sequence comparisons revealed that the zinc finger domains were absolutely conserved among the Zic family genes. Read More

    Oscillations of Subarachnoid Space Width as a Potential Marker of Cerebrospinal Fluid Pulsatility.
    Adv Exp Med Biol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Human Physiology, Medical University of Gdansk, Gdansk, Poland.
    In the cerebrospinal fluid (CSF) circulation, two components can be distinguished: bulk flow (circulation) and pulsatile flow (back and forth motion). CSF pulsatile flow is generated by both cardiac and respiratory cycles. Recent years have seen increased interest in cardiac and respiratory-driven CSF pulsatility as an important component of cerebral homeostasis. Read More

    Robot-Assisted Body-Weight-Supported Treadmill Training in Gait Impairment in Multiple Sclerosis Patients: A Pilot Study.
    Adv Exp Med Biol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Physiotherapy, College of Rehabilitation, Warsaw, Poland.
    This study deals with the use of a robot-assisted body-weight-supported treadmill training in multiple sclerosis (MS) patients with gait dysfunction. Twenty MS patients (10 men and 10 women) of the mean of 46.3 ± 8. Read More

    Effects of Manual Somatic Stimulation on the Autonomic Nervous System and Posture.
    Adv Exp Med Biol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Medical Oral and Biotechnological Science, "Gabriele d'Annunzio" University, Chieti-Pescara, Italy.
    Low back pain frequently involves a multifactorial etiology and requires medical attention. The aim of the study was to assess the associations among pain, posture, and autonomic nervous system function in patients with low back pain, using neuromuscular manual therapy versus a generic peripheral manual stimulation (back massage therapy). Twenty young patients with low back pain were enrolled into the study. Read More

    Very High Frequency Oscillations of Heart Rate Variability in Healthy Humans and in Patients with Cardiovascular Autonomic Neuropathy.
    Adv Exp Med Biol 2018 Feb 11. Epub 2018 Feb 11.
    Physical Therapy Department, Faculty of Social Welfare and Health Science, University of Haifa, Haifa, Israel.
    Literature reports on the very high frequency (VHF) range of 0.4-0.9 Hz in heart rate variability (HRV) are scanty. Read More

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