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Methods Cell Biol 2022 20;169:237-266. Epub 2022 Jan 20.

Department of Medicine, Duke University Medical Center, Durham, NC, United States; Department of Cell Biology, Duke University Medical Center, Durham, NC, United States. Electronic address:

The study of protein complexes and protein-protein interactions is of great importance due to their fundamental roles in cellular function. Proximity labeling, often coupled with mass spectrometry, has become a powerful and versatile tool for studying protein-protein interactions by enriching and identifying proteins in the vicinity of a specified protein-of-interest. Here, we describe and compare traditional approaches to investigate protein-protein interactions to current day state-of-the-art proximity labeling methods. Read More

Mitochondrion 2022 May 24. Epub 2022 May 24.

REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no 228, Porto 4050-313, Portugal. Electronic address:

From the simple unicellular eukaryote to the highly complex multicellular organism like Human, mitochondrion emerges as a ubiquitous player to ensure the organism's functionality. It is popularly known as "the powerhouse of the cell" by its key role in ATP generation. However, our understanding of the physiological relevance of mitochondria is being challenged by data obtained in different fields. Read More

Biochem Biophys Res Commun 2022 May 13;615:143-149. Epub 2022 May 13.

Department of Nanotechnology Engineering, Zonguldak Bülent Ecevit University, Incivez, Zonguldak, 67100, Turkey; Department of Biomedical Engineering, Zonguldak Bülent Ecevit University, Incivez, Zonguldak, 67100, Turkey. Electronic address:

In this study, we aimed to investigate ozonized oil nanoemulsions (OZNEs) as a radiosensitizer within B-16 melanoma and OV-90 ovarian cells under X-ray irradiation in vitro. Radiation sensitivity of OZNE treated B-16 melanoma cells and OV-90 ovarian cells were evaluated by performing cell cycle analysis, Reactive Oxygen Species (ROS) and ɣ-H2AX assays by flow cytometry. OZNEs induced G0-1 phase arrest of B-16 melanoma cells for all radiation doses and G2/M arrest for 8 Gy and 15 Gy doses. Read More

Cancer Treat Rev 2022 May 21;108:102417. Epub 2022 May 21.

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy.

Major advances have been made in precision medicine of breast cancer patients with a series of molecular targeted therapies now in clinical use or in late clinical development. These new therapeutic measures need to be integrated with local treatments, particularly with radiation therapy in both curative and advanced settings. Although a synergistic effect could be obtained between targeted therapies and irradiation, potential safety concerns should be carefully considered. Read More

J Chromatogr A 2022 May 19;1675:463157. Epub 2022 May 19.

School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P. R. China. Electronic address:

This review mainly focuses on the development and application of ordered mesoporous silica materials for solid-phase extraction in recent years. It overviews not only bare mesoporous silica but also the functionalized mesoporous silica with organic groups, molecularly imprinted polymers, and magnetic materials. These mesoporous silica materials were used as the extraction adsorbents in cartridge solid-phase extraction, dispersive solid-phase extraction, magnetic solid-phase extraction, micro-solid-phase extraction and matrix solid phase dispersion. Read More

ACS Appl Bio Mater 2022 May 27. Epub 2022 May 27.

Center for Biomedical Engineering, School of Engineering, Brown University, Providence, Rhode Island 02912, United States.

Despite numerous advances in treatments for cardiovascular disease, heart failure (HF) remains the leading cause of death worldwide. A significant factor contributing to the progression of cardiovascular diseases into HF is the loss of functioning cardiomyocytes. The recent growth in the field of cardiac tissue engineering has the potential to not only reduce the downstream effects of injured tissues on heart function and longevity but also re-engineer cardiac function through regeneration of contractile tissue. Read More

Medicine (Baltimore) 2022 May 27;101(21):e29470. Epub 2022 May 27.

IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.

Rationable: The aim of this study is to investigate the effects of an advanced neuroRehabilitation protocol using virtual reality in the treatment of a patient with fronto- temporal dementia due to TREM2 mutation.

Patients Concern: A 41-year-old caucasian male, affected by Nasu-Hakola Disease (NHD), presented a 1-year history of change in behavioral and cognitive functioning, before our observation. The onset of the disease was characterized by severe pain in the lower limbs and knees with limitations in the performance of daily life activities. Read More

Medicine (Baltimore) 2022 May 27;101(21):e29304. Epub 2022 May 27.

Department of Radiotherapy, the Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Gastric carcinoma (GC) is the fourth most common cause of cancer-related death worldwide. Most patients are diagnosed at later stage, because of few treatment options, the prognosis is poor. In recent years, however, Immune checkpoint inhibitors(ICIs), such as anti- programmed death-1 (PD-1), anti-PD-L1, and anti-cytotoxic T lymphocyte antigen 4, have emerged as promising therapeutic agents in GC. Read More

Am Soc Clin Oncol Educ Book 2022 Apr;42:1-12

Department of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Historically, multiple myeloma has been considered an incurable disease, mainly because of its recurrence after transient control. However, the landscape of multiple myeloma therapeutics has significantly changed over the last 2 decades, with disease remissions lasting much longer. The advent of modern-day induction regimens, usage of high-dose melphalan followed by autologous stem cell transplantation, and well-tolerated maintenance regimens has resulted in deeper and durable responses, with less frequent disease recurrences, and patients are living much longer. Read More

Trop Med Infect Dis 2022 May 9;7(5). Epub 2022 May 9.

Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY 12208, USA.

Impressive advances have been made in new cholera vaccine development and vaccination control strategies [... Read More

Methods Mol Biol 2022 ;2453:423-437

Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.

New approaches in high-throughput analysis of immune receptor repertoires are enabling major advances in immunology and for the discovery of precision immunotherapeutics. Commensurate with growth of the field, there has been an increased need for the establishment of techniques for quality control of immune receptor data. Our laboratory has standardized the use of multiple quality control techniques in immunoglobulin (IG) and T-cell receptor (TR) sequencing experiments to ensure quality control throughout diverse experimental conditions. Read More

Biometrics 2022 May 27. Epub 2022 May 27.

Department of Statistics, University of South Carolina, Columbia, SC, USA.

With recent advances in technologies to profile multi-omics data at the single-cell level, integrative multi-omics data analysis has been increasingly popular. It is increasingly common that information such as methylation changes, chromatin accessibility, and gene expression are jointly collected in a single-cell experiment. In biomedical studies, it is often of interest to study the associations between various data types and to examine how these associations might change according to other factors such as cell types and gene regulatory components. Read More

Elife 2022 May 27;11. Epub 2022 May 27.

Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.

Brain signal decoding promises significant advances in the development of clinical brain computer interfaces (BCI). In Parkinson's disease (PD), first bidirectional BCI implants for adaptive deep brain stimulation (DBS) are now available. Brain signal decoding can extend the clinical utility of adaptive DBS but the impact of neural source, computational methods and PD pathophysiology on decoding performance are unknown. Read More

Mar Drugs 2022 May 19;20(5). Epub 2022 May 19.

State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400, China.

Flexible marine natural products (MNPs), such as eribulin and bryostatin, play an important role in the development of modern marine drugs. However, due to the multiple chiral centers and geometrical uncertainty of flexible systems, configuration determinations of flexible MNPs face great challenges, which, in turn, have led to obstacles in druggability research. To resolve this issue, the comprehensive use of multiple methods is necessary. Read More

Mar Drugs 2022 Apr 29;20(5). Epub 2022 Apr 29.

Biorefining and Remediation Laboratory, Department of Process Engineering and Applied Science, Dalhousie University, 1360 Barrington St., Halifax, NS B3J 1Z1, Canada.

Hydrogels are three-dimensional crosslinked hydrophilic polymer networks with great potential in drug delivery, tissue engineering, wound dressing, agrochemicals application, food packaging, and cosmetics. However, conventional synthetic polymer hydrogels may be hazardous and have poor biocompatibility and biodegradability. Algal polysaccharides are abundant natural products with biocompatible and biodegradable properties. Read More

Mar Drugs 2022 Apr 19;20(5). Epub 2022 Apr 19.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Metastasis is responsible for the bad prognosis in cancer patients. Advances in research on metastasis prevention focus attention on the molecular mechanisms underlying cancer cell motility and invasion to improve therapies for long-term survival in cancer patients. The so-called "migrastatics" could help block cancer cell invasion and lead to the rapid development of antimetastatic therapies, improving conventional cancer therapies. Read More

J Imaging 2022 Apr 26;8(5). Epub 2022 Apr 26.

Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.

Recent advances in depth measurement and its utilization have made point cloud processing more critical. Additionally, the human head is essential for communication, and its three-dimensional data are expected to be utilized in this regard. However, a single RGB-Depth (RGBD) camera is prone to occlusion and depth measurement failure for dark hair colors such as black hair. Read More

J Imaging 2022 Apr 22;8(5). Epub 2022 Apr 22.

Division of Transdisciplinary Science, Japan Advanced Institute of Science and Technology, Nomi 923-1292, Japan.

The continuous advances in the technology of Convolutional Neural Network (CNN) and Deep Learning have been applied to facilitate various tasks of human life. However, security risks of the users' information and privacy have been increasing rapidly due to the models' vulnerabilities. We have developed a novel method of adversarial attack that can conceal its intent from human intuition through the use of a modified QR code. Read More

J Cardiovasc Dev Dis 2022 May 14;9(5). Epub 2022 May 14.

Department of Clinical Therapeutics, National Kapodestrian University of Athens, 11528 Athens, Greece.

The therapeutical advances in recent years in the field of oncology treatment have increased survival rates and improved the quality of life of oncology patients, thus turning cancer into a chronic disease. However, most of the new cancer treatments come at the expense of serious cardiovascular adverse events threatening the success story of these patients. The establishment of multidisciplinary medical teams to prevent, monitor, and treat cardiovascular diseases in cancer-treated patients is needed now more than ever. Read More

J Cardiovasc Dev Dis 2022 May 12;9(5). Epub 2022 May 12.

Department of Pediatrics, Section of Cardiology, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO 80045, USA.

Significant surgical and medical advances over the past several decades have resulted in a growing number of infants and children surviving with hypoplastic left heart syndrome (HLHS) and other congenital heart defects associated with a single systemic right ventricle (RV). However, cardiac dysfunction and ultimately heart failure (HF) remain the most common cause of death and indication for transplantation in this population. Moreover, while early recognition and treatment of single ventricle-related complications are essential to improving outcomes, there are no proven therapeutic strategies for single systemic RV HF in the pediatric population. Read More

J Cardiovasc Dev Dis 2022 Apr 27;9(5). Epub 2022 Apr 27.

Cardiothoracic and Vascular Division, Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.

Advances in computed tomography (CT) have resulted in a substantial increase in the size of datasets. We built a new concept of medical image compression that provides the best compromise between compression rate and image quality. The method is based on multiple contexts and regions-of-interest (ROI) defined according to the degree of clinical interest. Read More

J Cardiovasc Dev Dis 2022 Apr 26;9(5). Epub 2022 Apr 26.

Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M.K. Čiurlionis Str. 21, 03101 Vilnius, Lithuania.

: Advances in cancer therapy have dramatically improved outcomes for cancer pa-tients. However, cancer treatment can cause several cardiovascular (CV) complications, increasing cardiac mortality and morbidity in cancer patients and survivors. As a result, a new cardiology subspecialty-cardio-oncology (CO)-has been developed. Read More

Insects 2022 May 19;13(5). Epub 2022 May 19.

Department of Entomology, Gulf Coast Research and Education Center, University of Florida, Wimauma, FL 33598, USA.

The strawberry crop endures economic losses due to feeding injury from a number of phytophagous arthropod pests. A number of invasive pests have posed challenges to crop protection techniques in the strawberry cropping system recently. It is increasingly evident that sole reliance on chemical control options is not sustainable. Read More

Insects 2022 May 16;13(5). Epub 2022 May 16.

College of Plant Protection, Hebei Agricultural University, Baoding 071001, China.

Neuropterida is a relatively primitive group of Holometabola. There are about 6500 extant species. Many species of this group are natural enemies and can prey on a variety of agricultural pests. Read More

Insects 2022 May 13;13(5). Epub 2022 May 13.

Geological Research Center, Korea Institute of Geoscience and Mineral Resources, Daejeon 34132, Korea.

Under the influence of various circulation systems, the Holocene humidity conditions on the Mongolian Plateau are spatially heterogeneous and the underlying mechanism is still ambiguous. The complexity of climate change may affect the accuracy of assessing lake ecosystem evolution. In this study, based on the precise chronology, a chironomid assemblage sequence from the Darhad Basin in northern Mongolia is analyzed to elucidate the hydroclimate variation during the early-middle Holocene. Read More

Curr Oncol 2022 Apr 27;29(5):3082-3092. Epub 2022 Apr 27.

Trillium Health Partners, Division of Gynecologic Oncology, Mississauga, ON L5M 2N1, Canada.

Primary vaginal cancer is a rare gynecologic malignancy. Given the rarity of the disease, standardized approaches to management are limited, and a great variety of therapeutic conditions are endorsed. This paper reviews advances in surgical approaches, radiation, chemoradiation, and immunotherapy. Read More

Gels 2022 May 15;8(5). Epub 2022 May 15.

Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Hydrogels are biocompatible polymer systems, which have become a hotspot in biomedical research. As hydrogels mimic the structure of natural extracellular matrices, they are considered as good scaffold materials in the tissue engineering area for repairing dental pulp and periodontal damages. Combined with different kinds of stem cells and growth factors, various hydrogel complexes have played an optimistic role in endodontic and periodontal tissue engineering studies. Read More

Gels 2022 May 1;8(5). Epub 2022 May 1.

Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Poly(N-isopropylacrylamide) (PNIPAM) based electrically conductive hydrogels (PNIPAM-ECHs) have been extensively studied in recent decades due to their thermal-responsive (leading to the volume change of hydrogels) and electrically conductive performance. The incorporation of conductive components into the PNIPAM hydrogel network makes it become conductive hydrogel, and as a result, the PNIPAM hydrogel could become sensitive to an electrical signal, greatly expanding its application. In addition, conductive components usually bring new stimuli-responsive properties of PNIPAM-based hydrogels, such as near-infrared light and stress/strain responsive properties. Read More

Gels 2022 May 1;8(5). Epub 2022 May 1.

College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China.

Although many advances have been made in medicine, traumatic bleeding and wound infection are two of the most serious threats to human health. To achieve rapid hemostasis and prevent infection by pathogenic microbes, the development of new hemostatic and antibacterial materials has recently gained significant attention. In this paper, safe, non-toxic, and biocompatible polyvinyl alcohol (PVA); carboxymethyl cellulose (CMC), which contains several carboxyl and hydroxyl groups; and polyethylene glycol (PEG), which functions as a pore-forming agent, were used to prepare a novel PVA/CMC/PEG-based composite hydrogel with a macroporous structure by the freeze-thaw method and the phase separation technique. Read More

Biol Chem 2022 May 30. Epub 2022 May 30.

Biochemistry Center (BZH), Heidelberg University, D-69120 Heidelberg, Germany.

Transfer RNAs (tRNAs) are transcribed as precursor molecules that undergo several maturation steps before becoming functional for protein synthesis. One such processing mechanism is the enzyme-catalysed splicing of intron-containing pre-tRNAs. Eukaryotic tRNA splicing is an essential process since intron-containing tRNAs cannot fulfil their canonical function at the ribosome. Read More