Biochem Biophys Res Commun 2022 May 13;615:143-149. Epub 2022 May 13.
Department of Nanotechnology Engineering, Zonguldak Bülent Ecevit University, Incivez, Zonguldak, 67100, Turkey; Department of Biomedical Engineering, Zonguldak Bülent Ecevit University, Incivez, Zonguldak, 67100, Turkey. Electronic address:
In this study, we aimed to investigate ozonized oil nanoemulsions (OZNEs) as a radiosensitizer within B-16 melanoma and OV-90 ovarian cells under X-ray irradiation in vitro. Radiation sensitivity of OZNE treated B-16 melanoma cells and OV-90 ovarian cells were evaluated by performing cell cycle analysis, Reactive Oxygen Species (ROS) and ɣ-H2AX assays by flow cytometry. OZNEs induced G0-1 phase arrest of B-16 melanoma cells for all radiation doses and G2/M arrest for 8 Gy and 15 Gy doses. Read More