1,716 results match your criteria Advances in Clinical and Experimental Medicine[Journal]


Quantitative shear wave elastography compared to standard ultrasound (qualitative B-mode grayscale sonography and quantitative power Doppler) for evaluation of achillotendinopathy in treatment-naïve individuals: A cross-sectional study.

Adv Clin Exp Med 2022 May 20. Epub 2022 May 20.

Chongqing Jiulongpo District Second People's Hospital, China.

Background: Achillotendinopathy is reported as an overuse disorder and/or degeneration change of the tendon. The diagnosis of tendinopathy is not always easy through imaging modalities. The B-mode grayscale sonography and power Doppler are well-established methods aimed at visualising tendon structure, but have limited sensitivity and lack conventional sonographic characteristics in symptomatic patients. Read More

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The influence of cord blood renalase and advanced oxidation protein products (AOPPs) on perinatal and anthropometric parameters of newborns of mothers with gestational hypertension.

Adv Clin Exp Med 2022 May 19. Epub 2022 May 19.

Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.

Background: Renalase is an enzyme secreted by the kidneys, which takes part in the regulation of arterial pressure, myocardial contractility and modulation of vascular resistance, but its effect on renalase levels in newborns has not been studied yet. The levels of advanced oxidation protein products (AOPPs) were also evaluated as a marker of oxidative stress.

Objectives: This study examined whether renalase and AOPP levels are different in the cord blood of newborns exposed to gestational hypertension (HT). Read More

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Efficacy of different intensity of aquatic exercise in enhancing remyelination and neuronal plasticity using cuprizone model in male Wistar rats.

Adv Clin Exp Med 2022 May 19. Epub 2022 May 19.

Department of Research and Development, Saveetha Insititute of Medical & Technical Sciences, Chennai, India.

Background: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). Most exercise studies concentrate on the impact of exercise on cardiovascular system; this study aims to present the effects of exercise of varying intensity on the nervous system. Most recently in MS, positive outcomes were obtained with resistance and high-intensity exercises. Read More

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Phenotyping in heart failure with preserved ejection fraction: A key to find effective treatment.

Adv Clin Exp Med 2022 May 18. Epub 2022 May 18.

1st Chair and Department of Cardiology, Medical University of Warsaw, Poland.

Heart failure with preserved ejection fraction (HFpEF) is an increasingly widespread medical condition, with excessive morbidity and mortality. Recently, for the first time in HFpEF, a reduction in the primary composite outcome of cardiovascular death or HF hospitalization was shown with empagliflozin. The failure of previous clinical trials in HFpEF might have resulted from suboptimal patient selection and inclusion of patients without "true" or clinically significant HFpEF. Read More

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A prognostic signature based on the expression profile of the ferroptosis-related long non-coding RNAs in hepatocellular carcinoma.

Authors:
Xixi Lin Sijie Yang

Adv Clin Exp Med 2022 May 18. Epub 2022 May 18.

Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning, China66.

Background: Ferroptosis is a special form of cell death with extensive biological associations with various cancers; however, the role of aberrantly expressed ferroptosis-related long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC) remains unclear.

Objectives: To explore the role and prognostic value of ferroptosis-related lncRNAs in HCC and to screen potential therapeutic targets.

Material And Methods: The RNA-seq data for 424 HCC patients and clinical data for 377 HCC patients were obtained from The Cancer Genome Atlas (TCGA) and evaluated using the Pearson's test to identify differentially expressed lncRNAs. Read More

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The assessment of the risk of COVID-19 infection and its course in the medical staff of a COVID-only and a non-COVID hospital.

Adv Clin Exp Med 2022 May 13. Epub 2022 May 13.

Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Poland.

Background: Medical workers are a group that is particularly vulnerable to infection during the coronavirus disease 2019 (COVID-19) pandemic.

Objectives: The study aimed to assess the risk of COVID-19 infection and its course in the medical staff of a COVID-only and a non-COVID hospital.

Material And Methods: The observational study included 732 participants who were medical workers. Read More

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RPS27 selectively regulates the expression and alternative splicing of inflammatory and immune response genes in thyroid cancer cells.

Adv Clin Exp Med 2022 May 12. Epub 2022 May 12.

Ultrasound Department, People's Hospital of Xinjiang Uygur Autonomous Region, China.

Background: The expression of ribosomal protein S27 (RPS27) is upregulated in multiple human malignancies. In thyroid cancer, the expression of RPS27 is associated with patient outcomes. However, the carcinogenic mechanisms of RPS27 and functions of RPS27 in the initiation and progression of thyroid cancer are still not clear. Read More

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Aging, depression and dementia: The inflammatory process.

Adv Clin Exp Med 2022 May;31(5):469-473

Department of Nursing, Pharmacology and Physiotherapy, Faculty of Medicine and Nursing, University of Córdoba, Maimonides Institute of Biomedical Research of Córdoba (IMIBIC), Reina Sofia University Hospital, Spain.

Population aging that we are currently witnessing has led to an increase in chronic age-related diseases, with dementia and depression being highlighted. Several studies establish a relationship between dementia and depression, although without defining the mechanism that links them. Some studies establish depression as a prodrome of dementia, while others consider it a risk factor for dementia. Read More

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Neutrophil-to-lymphocyte ratio as a predictor of inflammatory response in patients with acute kidney injury after transcatheter aortic valve implantation.

Adv Clin Exp Med 2022 May 12. Epub 2022 May 12.

Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poland.

Background: Persistent inflammatory response after transcatheter aortic valve implantation (TAVI) is one of the possible causes of early and mid-term postprocedural adverse events.

Objectives: To establish the predictive role of whole blood parameters on inflammatory response characteristics within a 1-year follow-up.

Material And Methods: The study group comprised 163 consecutive patients (52. Read More

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Effects of exposure to air pollution on acute cardiovascular and respiratory admissions to the hospital and early mortality at emergency department.

Adv Clin Exp Med 2022 May 11. Epub 2022 May 11.

Institute of Heart Diseases, Wroclaw Medical University, Poland.

Background: Particulate matter (PM) and NO2 induce pathophysiological changes which contribute to an increased incidence of acute cardiovascular (CV) and respiratory (Rp) events.

Objectives: To analyze the relationship between air quality and the frequency of admissions to the emergency department (ED) due to the CV diseases and Rp causes.

Material And Methods: The study analyzed the reasons for admissions to the ED during the cold periods from January 2017 to January 2020. Read More

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The effect of breathing an oxygen-enriched mixture on tissue saturation in obese women.

Adv Clin Exp Med 2022 May 11. Epub 2022 May 11.

Department of Physiology and Biochemistry, Poznan University of Physical Education, Poland.

Background: Physical activity undertaken in the treatment process additionally increases the oxygen demand of the working muscles. It seems interesting to see whether a delivery of an enriched respiratory mixture can have an impact on lower acidification of working muscles and oxygenation of tissues.

Objectives: To assess tissue saturation and the level of acidification at rest and during exercise while breathing atmospheric air or an oxygen-enriched mixture. Read More

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Preoperative and postoperative diagnostic efficiency of multi-inflammatory index on pain scoring of degenerated intervertebral disc.

Adv Clin Exp Med 2022 May 11. Epub 2022 May 11.

Department of Neurosurgery, Siirt Training and Research Hospital, Turkey.

Background: The inflammatory index can be useful for neurosurgeons to understand and grade pain in degenerated intervertebral disc (DIVD).

Objectives: The study focused on the value of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and the inflammatory multiple indices (MIs), and aimed to compare its efficiency with the preoperative and postoperative pain scale and scoring algorithms.

Material And Methods: A total of 88 DIVD patients were included in this retrospective clinical cohort study. Read More

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Ambulatory pulse pressure and its contributors in autosomal dominant polycystic kidney disease.

Adv Clin Exp Med 2022 May;31(5):575-578

Department of Nephrology, Transplantology and Internal Medicine, Faculty of Medicine, Medical University of Gdańsk, Poland.

Background: Pulse pressure (PP) is a pulsatile component of blood pressure (BP), strongly correlated with arterial stiffness (AS) and impacting prognosis. Disproportionally increased PP values in individuals with autosomal dominant polycystic kidney disease (ADPKD) should be expected, given the multifactorial cardiovascular involvement in the natural course of this disease.

Objectives: To investigate ambulatory PP in a group of ADPKD patients, and to examine the impact of age, sex, kidney function, hypertension, circadian rhythm, and antihypertensive drugs (AH) on studied parameters. Read More

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Real-world diagnostic value of a nationwide standardized COVID-19 triage chart in Turkey.

Adv Clin Exp Med 2022 May 4. Epub 2022 May 4.

Department of Internal Medicine Clinic, Ankara Polatlı Duatepe State Hospital, Turkey.

Background: Effective triage is critical during the coronavirus disease 2019 (COVID-19) pandemic. An appropriate triage plan is crucial to direct suspected COVID-19 cases to a designated area, in order to separate such patients from other patients and staff.

Objectives: To report the diagnostic value of the "Possible Coronavirus Disease 2019 (COVID-19) Case Questioning Guide for Outpatients", a nationwide standard triage chart, and of the individual questions within the triage chart for detecting COVID-19 in patients admitted to our hospital. Read More

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MiR-218 promotes oxidative stress and inflammatory response by inhibiting SPRED2-mediated autophagy in HG-induced HK-2 cells.

Adv Clin Exp Med 2022 May 4. Epub 2022 May 4.

Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, China.

Background: Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM). MicroRNA (miR)-218 is associated with the development of diabetes. Besides, sprouty-related EVH1 domain containing 2 (SPRED2), the downstream target of miR-218, is involved in insulin resistance and inflammation. Read More

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Thyroid nodule ultrasound accuracy in predicting thyroid malignancy based on TIRADS system.

Adv Clin Exp Med 2022 May 4. Epub 2022 May 4.

Department of Ultrasound, Penglai People's Hospital, Yantai, China.

Background: A frequent prevalence of thyroid nodules in patients prioritizes the need for an accurate method that characterizes them as benign or malignant. Fine-needle aspiration biopsy (FNAB) and thyroid ultrasonography (USG) are currently used for this purpose. However, since FNAB is complicated, time-consuming and expensive, thyroid USG, a fast and highly sensitive method, is preferably used. Read More

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Platelet sTWEAK and plasma IL-6 are associated with 18F-fluorodeoxyglucose uptake in right ventricles of patients with pulmonary arterial hypertension: A pilot study.

Adv Clin Exp Med 2022 Apr 25. Epub 2022 Apr 25.

Department of Cardiology, Medical University of Bialystok, Poland.

Background: Cytokines soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin 6 (IL-6) are involved in immune response, proliferation, apoptosis, and cardiovascular pathologies. We have previously confirmed that changes of their platelet or plasma contents are associated with pulmonary arterial hypertension (PAH). The positron emission tomography/magnetic resonance imaging (PET/MRI) hybrid imaging provides detailed insight into right ventricle (RV) hemodynamic and metabolic function. Read More

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The influence of venetoclax, used alone or in combination with cladribine (2-CdA), on CLL cells apoptosis in vitro: Preliminary results.

Adv Clin Exp Med 2022 Apr 25. Epub 2022 Apr 25.

Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Medical University of Wroclaw, Poland.

Background: Venetoclax (VEN), a highly selective BCL-2 inhibitor, is successfully used in the treatment of chronic lymphocytic leukemia (CLL). The purine analogue - cladribine (2-CdA) - is also administered to CLL patients, especially as a part of chemoimmunotherapy.

Objectives: To compare the effects of the VEN+2-CdA regimen with that of the 2 drugs used alone on the apoptosis of CLL lymphocytes in vitro. Read More

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Impact of moderately reduced renal function on the diagnostic and prognostic value of galectin-3 in patients with exertional dyspnea.

Adv Clin Exp Med 2022 Apr 25. Epub 2022 Apr 25.

Institute of Heart Diseases, Wroclaw Medical University, Poland.

Background: Blood concentration of galectin-3 (Gal-3) - a biomarker of fibrosis useful in diagnostics and prognostication in heart failure (HF) - is known to be elevated in patients with renal impairment, a condition which often accompanies cardiac insufficiency.

Objectives: To investigate the effect of moderately reduced renal function (estimated glomerular filtration rate (eGFR) 30-60 mL/min/1.73 m2) on the diagnostic and prognostic utility of circulating Gal-3 in patients with HF with preserved ejection fraction (HFpEF). Read More

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Arsenic trioxide induces the differentiation of retinoic acid-resistant neuroblastoma cells via upregulation of HoxC9.

Adv Clin Exp Med 2022 Apr 25. Epub 2022 Apr 25.

Pediatric Hematology/Oncology, Children's Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Background: Neuroblastoma (NB) is one of the most common extracranial tumors with limited therapeutic options. Retinoic acid (RA) has been identified to play anticancer role against NB cells by inducing the differentiation and apoptosis of immature neuroblasts. However, silencing HoxC9 promoter by EZH2-induced H3K27me3 hypermethylation can lead to RA resistance. Read More

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Does PET scan have any role in the diagnosis of perineural spread associated with the head and neck tumors?

Adv Clin Exp Med 2022 Apr 25. Epub 2022 Apr 25.

Department of Radiology, Shengli Oilfield Central Hospital, Dongying, China.

Background: Perineural spread of head and neck tumors is linked to a worse chance of survival as well as a higher risk of local recurrence and metastasis. Particle emission tomography/computed tomography (PET/CT) using 2-[fluorine-18]fluoro-2-deoxy-d-glucose (FDG) is part of the work-up and follow-up of many afflicted patients, and radiologists play an essential role in the assessment and management of head and neck cancer.

Objectives: The purpose of the current study was to investigate the diagnostic performance of 18F-FDG PET in detecting perineural spread among patients with head and neck tumors through a meta-analysis. Read More

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Rifaximin in gut microbiota modification in acute pancreatitis: 15 years of retrospective clinical study.

Adv Clin Exp Med 2022 Apr;31(4):399-405

Department of Gastroenterology, Central Clinical Hospital of The Ministry of Interior and Administration, Warsaw, Poland.

Background: Gut decontamination could have some benefits in preventing infectious complications in acute pancreatitis (AP).

Objectives: To investigate whether the administration of rifaximin could have an impact on the outcomes of AP.

Material And Methods: We conducted a retrospective study on 373 patients with a median age of 50 years that were admitted to our Department of Gastroenterology in the years 2001-2016 with a diagnosis of AP. Read More

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Correlation between age and curative effects of selective dorsal neurectomy for primary premature ejaculation.

Adv Clin Exp Med 2022 Apr 19. Epub 2022 Apr 19.

2nd Department of Urology, Second Affiliated Hospital of Harbin Medical University, China.

Background: The use of selective dorsal neurectomy (SDN) as a surgical treatment of premature ejaculation (PE) has increased for many years in Asian countries.

Objectives: To investigate the correlation between age and curative effects of SDN in primary premature ejaculation (PPE) in mainland China.

Material And Methods: From September 2016 to September 2020, 65 patients with PPE treated with SDN were selected for study. Read More

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Factors predictive of anti-spike antibody titers after COVID-19 vaccination in hemodialysis patients.

Adv Clin Exp Med 2022 Apr 19. Epub 2022 Apr 19.

Department of Nephrology, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.

Background: Hemodialysis (HD) patients have a high prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality, but they may have a weak response to coronavirus disease 2019 (COVID-19) vaccines.

Objectives: This study aimed to evaluate factors predictive of humoral response in HD patients vaccinated against SARS-CoV-2 infection.

Material And Methods: This is a 2-center observational study including HD patients who received the BNT162b2 mRNA vaccine followed by serological measurements 20 days and 4 weeks after the 1st and 2nd dose, respectively. Read More

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Trimethylamine N-oxide in cardiovascular disease.

Adv Clin Exp Med 2022 Apr 19. Epub 2022 Apr 19.

Institute for Heart Diseases, Wroclaw Medical University, Poland.

Although traditional cardiovascular risk factors are well established and understood, mortality and morbidity in patients with cardiovascular disease (CVD) remains high. Exploring new pathophysiological pathways enables a better understanding of CVD at both the molecular and clinical levels. Gut microbiota as a potential modulator of CVD are the subject of extensive research. Read More

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Gastrointestinal hemorrhage as an acute-on-chronic liver failure trigger in cirrhotic patients.

Adv Clin Exp Med 2022 Apr 19. Epub 2022 Apr 19.

Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, Poland.

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of chronic liver disease associated with organ failures and very high short-term mortality.

Objectives: To assess the incidence and factors predisposing to ACLF in patients with liver cirrhosis hospitalized due to acute gastrointestinal bleeding (GIB).

Material And Methods: We collected and retrospectively analyzed the data of 89 consecutive patients (59 males (66. Read More

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MicroRNA-139-5p negatively regulates NME1 expression in hepatocellular carcinoma cells.

Adv Clin Exp Med 2022 Apr 19. Epub 2022 Apr 19.

Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, China.

Background: High expression of NME1 is associated with hepatocellular carcinoma (HCC) progression and poor prognosis. However, there are few reports on the association between NME1 and microRNAs (miRNAs) in HCC progression.

Objectives: To explore miRNAs that regulate NME1 expression in HCC. Read More

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mGluR5 promotes the progression of multiple myeloma in vitro via Ras-MAPK signaling pathway.

Adv Clin Exp Med 2022 04 8. Epub 2022 Apr 8.

Third Affiliated Hospital of Southern Medical University, Guangzhou, China.

Background: Multiple myeloma (MM) is a malignant plasma cancer which remains difficult to be cured. Recently, numerous research studies have appeared, exploring MM from molecular level. However, there is no study about the impact of metabotropic glutamate receptors (mGluRs), especially mGluR5, on MM progression. Read More

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The arterial stiffness changes in hemodialysis patients with chronic kidney disease: The impact on mortality.

Adv Clin Exp Med 2022 Apr 8. Epub 2022 Apr 8.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Poland.

Background: Patients with kidney disease suffer from high cardiovascular risk due to classic and disease-specific risk factors. Arterial stiffness is a novel cardiovascular risk factor whose role is yet to be established. High-resolution echo-tracking is a developing method for the assessment of local arterial stiffness. Read More

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Hypoxia-inducible factor-2α promotes EMT in esophageal squamous cell carcinoma through the Notch pathway.

Adv Clin Exp Med 2022 Apr 8. Epub 2022 Apr 8.

Department of Thoracic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Esophageal cancer is one of the most lethal tumors worldwide. The most common histological type in China is esophageal squamous cell carcinoma (ESCC), accounting for 90% of cases. Esophageal cancer occurs at a high incidence in certain areas, among which China has the highest incidence. Read More

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