229,812 results match your criteria Advances in Anatomy Embryology and Cell Biology [Journal]


New molecular approaches to Alzheimer's disease.

Clin Biochem 2019 Apr 21. Epub 2019 Apr 21.

Vita-Salute San Raffaele University, Milan, Italy; Unit of Genomics for Human Disease Diagnosis, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy; IRCCS San Raffaele Hospital, Clinical Molecular Biology Laboratory, Milan, Italy. Electronic address:

Alzheimer's disease is a neurodegenerative disorder and the most common and devastating form of dementia. It affects mainly older people, accounting for 50-80% of dementia cases. The age is the main associated risk factor and based on the onset age, early-onset (EOAD) or late-onset (LOAD) forms are distinguished. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.010DOI Listing
April 2019
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Single Nanoparticle Electrochemistry.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Apr 24. Epub 2019 Apr 24.

School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China; email: ;

Experimental techniques to monitor and visualize the behaviors of single nanoparticles have not only revealed the significant spatial and temporal heterogeneity of those individuals, which are hidden in ensemble methods, but more importantly, they have also enabled researchers to elucidate the origin of such heterogeneity. In pursuing the intrinsic structure-function relations of single nanoparticles, the recently developed stochastic collision approach demonstrated some early promises. However, it was later realized that the appropriate sizing of a single nanoparticle by an electrochemical method could be far more challenging than initially expected owing to the dynamic motion of nanoparticles in electrolytes and complex charge-transfer characteristics at electrode surfaces. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114902DOI Listing

Advances in the Use of Microfluidics to Study Crystallization Fundamentals.

Annu Rev Chem Biomol Eng 2019 Apr 24. Epub 2019 Apr 24.

Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France; email: , , ,

This review compares droplet-based microfluidic systems used to study crystallization fundamentals in chemistry and biology. An original high-throughput droplet-based microfluidic platform is presented. It uses nanoliter droplets, generates a chemical library, and directly solubilizes powder, thus economizing both material and time. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030312DOI Listing

Overtones of νC≡N Vibration as a Probe of Structure of Liquid CHCN, CDCN and CClCN. Combined IR, NIR, and Raman Spectroscopic Studies with Anharmonic DFT Calculations.

J Phys Chem A 2019 Apr 24. Epub 2019 Apr 24.

The νCN band ( νC≡N) is a sensitive probe of the state of compounds with nitrile groups. Hence, physicochemical properties of acetonitrile and its derivatives have been frequently investigated by means of vibrational (IR and Raman) spectroscopy. Near-infrared (NIR) spectroscopy combined with high-level quantum mechanical calculations offers deeper physical insight into the structure of liquid nitriles, not available from the fundamental region. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b02170DOI Listing

First description of Theiler's disease associated virus (TDAV) infection and epidemiological investigation of equine pegivirus (EPgV) and equine hepacivirus (EqHV) coinfection in Brazil.

Transbound Emerg Dis 2019 Apr 24. Epub 2019 Apr 24.

Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Recent advances in the study of equine pegivirus (EPgV), Theiler's disease associated virus (TDAV) and equine hepacivirus (EqHV) highlight their importance to veterinary and human health. To gain some insight into virus distribution, possible risk factors, presence of liver damage and genetic variability of these viruses in Brazil, we performed a cross-sectional study of EPgV and TDAV infections using a simultaneous detection assay, and assessed EqHV coinfection in different horse cohorts. Of the 500 serum samples screened, TDAV, EPgV and EPgV-EqHV were present in 1. Read More

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http://dx.doi.org/10.1111/tbed.13210DOI Listing

Nature of halogen-centered intermolecular interactions in crystal growth and design: Fluorine-centered interactions in dimers in crystalline hexafluoropropylene as a prototype.

J Comput Chem 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemical System Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

The wide occurrence of halogen-centered noncovalent interactions in crystal growth and design prompted this study, which includes a mini review of recent advances in the field. Particular emphasis is placed on providing compelling theoretical evidence of the formation of these interactions between sites of positive electrostatic potential, as well as between sites of negative electrostatic potential, localized on the electrostatic surfaces of the bound fluorine atoms in a prototypical system, hexafluoropropylene (C F ), upon its interaction with another same molecule to form (C F ) dimers. The existence of σ- and π-hole interactions is shown for the stable dimers. Read More

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http://dx.doi.org/10.1002/jcc.25836DOI Listing

The Wnt signaling pathway: a potential therapeutic target against cancer.

Ann N Y Acad Sci 2019 Apr 24. Epub 2019 Apr 24.

Division of Molecular Medicine, Bose Institute, Kolkata, India.

The role of the evolutionarily conserved Wnt signaling pathway is well documented in several cellular processes, such as cell proliferation, differentiation, cell motility, and maintenance of the stem cell niche. The very first indication that aberrant Wnt signaling can cause carcinogenesis came from a finding that the mutation of the adenomatous polyposis coli gene (APC) predisposes a person to colorectal carcinoma. Later, with progressing research it became clear that abnormal activation or mutation of the genes related to this pathway could drive tumorigenesis. Read More

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http://dx.doi.org/10.1111/nyas.14027DOI Listing

Chemical composition of DNA-encoded libraries, past present and future.

Org Biomol Chem 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

DNA-encoded libraries represent an exciting and powerful modality for high-throughput screening. In this article, we highlight recent important advances in this field and also suggest some important directions that would make the technology even more powerful. Read More

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http://dx.doi.org/10.1039/c9ob00581aDOI Listing

Automatic localization of anatomical regions in medical ultrasound images of rheumatoid arthritis using deep learning.

Proc Inst Mech Eng H 2019 Apr 24:954411919845747. Epub 2019 Apr 24.

3 Department of Biomedical Engineering, Vels Institute of Science, Technology and Advanced Studies, Chennai, India.

The pace of population aging is growing faster worldwide. The quality of life of the aging population is mostly affected by rheumatic diseases. With the increasing rate of rheumatoid arthritis in the aging population, technological advances in the field of automatic image processing and analysis have paved way for automatic detection and diagnosis of arthritis based on how the grade of the synovial region is designed. Read More

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http://dx.doi.org/10.1177/0954411919845747DOI Listing

Fluoroscopic Self-Expandable metallic stent placement for treating postoperative nonanastomotic strictures in the proximal small bowel: A 15-Year single institution experience.

Br J Radiol 2019 Apr 24:20180957. Epub 2019 Apr 24.

3 Department of Radiologic Technology, Cheju Halla University , Jeju , Republic of Korea.

Objectives: To evaluate the efficacy and safety of fluoroscopic self-expandable metallic stent (SEMS) placement for treating postoperative nonanastomotic strictures in the proximal small bowel.

Methods: Data from eight consecutive patients (mean age, 63.8 ± 6. Read More

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http://dx.doi.org/10.1259/bjr.20180957DOI Listing

Quantitative evaluation of Beta-Amyloid brain PET imaging in dementia: A comparison between two commercial software packages and the clinical report.

Br J Radiol 2019 Apr 24:20181025. Epub 2019 Apr 24.

2 Department of Nuclear Medicine, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road , London , UK.

Objectives: To compare commercially available image analysis tools Hermes BRASS and Siemens with clinical assessment in 18F-Florbetapir PET scans.

Methods: 225 scans were reported by clinicians and quantified using two software packages. Scans were classified into type A (typical features) or non-type A (atypical features) for both positive and negative scans. Read More

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http://dx.doi.org/10.1259/bjr.20181025DOI Listing

Optimisation and usefulness of quantitative analysis of F-florbetapir PET.

Br J Radiol 2019 Apr 24:20181020. Epub 2019 Apr 24.

1 Radiological Sciences Unit, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road , London , UK.

Objectives: This study investigates the usefulness of quantitative SUVR thresholds on sub types of typical (type A) and atypical (non-type A) positive (Aβ+) and negative (Aβ-) F-florbetapir scans and aims to optimise the thresholds.

Methods: Clinical F-florbetapir scans ( = 100) were categorised by sub type and visual reads were performed independently by three trained readers. Inter reader agreement and reader-to-reference agreement were measured. Read More

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http://dx.doi.org/10.1259/bjr.20181020DOI Listing

Contrast enhanced digital mammography versus magnetic resonance imaging for accurate measurement of the size of breast cancer.

Br J Radiol 2019 Apr 24:20180929. Epub 2019 Apr 24.

1 Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of medicine , Seoul , Korea.

Objective: To compare the accuracy of contrast-enhanced digital mammography (CEDM) and MRI, including maximal intensity projection (MIP) images, for measuring the tumour size of breast cancer.

Methods: We included 52 females (mean age, 50.9 years) with surgery due to breast cancer, and measured maximum diameter of main mass on mediolateral oblique (MLO) and craniocaudal (CC) views of mammography and CEDM; sagittal, axial MIP images, and early dynamic contrast-enhanced MRI (CEMRI) before surgery. Read More

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http://dx.doi.org/10.1259/bjr.20180929DOI Listing

Prostate cancer dose-response, fractionation sensitivity and repopulation parameters evaluation from 25 international radiotherapy outcome data sets.

Br J Radiol 2019 Apr 24:20180823. Epub 2019 Apr 24.

5 Radiation Therapy, Candiolo Cancer Institute - FPO , IRCCS, Candiolo (To) , Italy.

Objective: This study was undertaken to model the biochemical free survival at 5 years and to evaluate the parameters defining dose-response curve, dose-fractionation radiosensitivity and repopulation.

Methods: It was carried out a literature search on Pubmed to retrieve data sets of patients treated with external beam radiation therapy of 1.8-4. Read More

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http://dx.doi.org/10.1259/bjr.20180823DOI Listing

The clinical utility of phase-based respiratory gated PET imaging based on visual feedback with a head-mounted display system.

Br J Radiol 2019 Apr 24:20180233. Epub 2019 Apr 24.

3 Department of Radiological Sciences, Graduate School of Medicine, Tokyo Metropolitan University , Tokyo.

Objective: We developed a new respiratory-gated positron emission tomography (PET) imaging method (RGV-PET) that phase-based respiratory gated PET imaging (RG-PET) combine with head-mounted display (HMD)-guided "visual feedback." The purpose of this study was to investigate whether RGV-PET is effective for stabilizing the quantitativeness of tumors in the phase-based respiratory gating method.

Methods: Of the 41 enrolled patients with hepatobiliary or pancreatic cancer, 20 patients underwent RGV-PET and the remaining 21 patients underwent RG-PET. Read More

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http://dx.doi.org/10.1259/bjr.20180233DOI Listing
April 2019
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Dose-painted volumetric modulated arc therapy of high-grade glioma using 3,4-dihydroxy-6-[F]fluoro-l-phenylalanine positron emission tomography.

Br J Radiol 2019 Apr 24:20180901. Epub 2019 Apr 24.

3 Department of Radiation Oncology, BC Cancer - Vancouver , Vancouver , British Columbia, Canada.

Objectives: To determine whether dose painting with volumetric modulated arc therapy (VMAT) for high-grade gliomas using 3,4-dihydroxy-6-[F]fluoro- l -phenylalanine (F-FDOPA) positron emission tomography (PET) could achieve dose-escalated coverage of biological target volumes (BTVs) without increasing the dose to cranial organs at risk.

Methods: Ten patients with high-grade gliomas underwent CT, MRI, and F-FDOPA PET/CT images for postoperative radiation therapy planning. Two VMAT plans were retrospectively generated for each patient: a conventional plan with 60 Gy in 30 fractions to the planning target volume (PTV) delineated on MRI and a dose-escalated plan with a maximum dose of 80 Gy in 30 fractions to BTVs. Read More

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http://dx.doi.org/10.1259/bjr.20180901DOI Listing

Quantitative study of liver hemodynamic changes in rats with small-for-size syndrome by the 4D-CT perfusion technique.

Br J Radiol 2019 Apr 24:20180847. Epub 2019 Apr 24.

1 Department of Radiology, The Sixth Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Objective: The microcirculatory hemodynamic changes of small-for-size syndrome (SFSS) are still unclear. In this study, they were investigated by four-dimensional CT perfusion (4D-CTP) technique.

Methods: The sham group, 50, 60, 70 and 80 % partial hepatectomy (PH) rat groups were established. Read More

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http://dx.doi.org/10.1259/bjr.20180847DOI Listing

Trajectories of hemoglobin A1c and BMI z-score over four decades among 2-18 year olds with type 1 diabetes.

Pediatr Diabetes 2019 Apr 24. Epub 2019 Apr 24.

University of Colorado School of Medicine, Departments of Pediatrics and Epidemiology, Denver CO, US.

Objectives: To determine trajectories of glycemic control and BMI z-score in a large pediatric sample with type 1 diabetes (T1D) over a 38-year period, and to evaluate sex differences and temporal changes in the prevalence of these trajectories.

Methods: We conducted a longitudinal, retrospective study of 7002 2-18 year olds with T1D followed between 1978 and 2016 at a single center. Group-based modeling was used to identify trajectories for hemoglobin A1c (HbA1c) and BMI z-score. Read More

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http://dx.doi.org/10.1111/pedi.12862DOI Listing

A methodological proposal for the analysis of Cladocera (Crustacea, Branchiopoda) subfossils from sediments of temporary aquatic ecosystems.

Braz J Biol 2019 Apr 18. Epub 2019 Apr 18.

Laboratório de Ecologia Aquática, Conservação e Evolução, Universidade Federal de Ouro Preto - UFOP, Campus Morro do Cruzeiro, s/n, Ouro Preto, MG, Brasil.

The main objective of the present study was to promote some adaptations to the standard methodology used in the analysis of Cladocera subfossils. The samples used in this study were collected at Lagoa dos Coutos, a temporary lake located on an outcrop with iron-rich duricrust in the Serra do Gandarela (Minas Gerais, Brazil). The sediment from this pond, typical of temporary ecosystems in the region, is characterized by rigid concretions that are difficult to dissolve in aqueous media, making it difficult to visualize and analyze subfossils taxa. Read More

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http://dx.doi.org/10.1590/1519-6984.192126DOI Listing

Patent landscape of molecular and cellular targeted therapies for recessive dystrophic epidermolysis bullosa.

Expert Opin Ther Pat 2019 Apr 24:1-11. Epub 2019 Apr 24.

a NUCEL - School of Medicine , University of Sao Paulo , São Paulo , SP , Brazil.

Introduction: Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a monogenetic inherited genodermatosis associated with deleterious mutations in the gene encoding type VII collagen (COL7A1). COL7A1 is essential for promoting attachment of the epidermis to the dermis, and its dysfunction may lead to generalized mucosal and cutaneous blistering associated to severe deformities. Currently, management of RDEB patients is limited to supportive care, being aimed at treating and preventing common complications associated with this condition. Read More

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http://dx.doi.org/10.1080/13543776.2019.1608181DOI Listing

Genomic and Genetic Approaches to Deciphering Acute Respiratory Distress Syndrome Risk and Mortality.

Antioxid Redox Signal 2019 Apr 24. Epub 2019 Apr 24.

University of Arizona, Health Sciences, Tucson, Arizona, United States ;

Significance: Acute respiratory distress syndrome (ARDS) is a severe, heterogeneous critical illness with staggering mortality that is influenced by environmental factors, such as mechanical ventilation, and genetic factors. Significant unmet needs in ARDS is addressing the paucity of validated predictive biomarkers for ARDS risk and susceptibility that hamper the conduct of successful clinical trials in ARDS and the complete absence of novel disease-modifying therapeutic strategies. Recent Advances: The current ARDS definition relies on clinical characteristics that fail to capture the diversity of disease pathology, severity, and mortality risk. Read More

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http://dx.doi.org/10.1089/ars.2018.7701DOI Listing

Spin Selectivity in Photoinduced Charge Transfer Mediated by Chiral Molecules.

ACS Nano 2019 Apr 24. Epub 2019 Apr 24.

Optical control and readout of electron spin and spin currents in thin films and nanostructures have remained attractive yet challenging goals for emerging technologies designed for applications in information processing and storage. Recent advances in room-temperature spin polarization using nanometric chiral molecular assemblies suggest that chemically modified surfaces or interfaces can be used for optical spin conversion by exploiting photoinduced charge separation and injection from well-coupled organic chromophores or quantum dots. Using light to drive photoexcited charge-transfer processes mediated by molecules with central or helical chirality enables indirect measurements of spin polarization attributed to the chiral-induced spin selectivity effect, and of the efficiency of spin-dependent electron transfer relative to competitive radiative relaxation pathways. Read More

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http://dx.doi.org/10.1021/acsnano.9b01876DOI Listing

[Advances in aquatic bio-inspired medical adhesives].

Authors:
Yun Wu Jian Li

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):325-333

Pharmacy, People's Liberation Army Southern Theater General Hospital, Guangzhou 510010, P.R.China.

In recent years, due to the dramatic increase in the number of surgical operations, there has been a clinically significant increase in the demand for medical adhesives capable of cohesion in a moist environment that can overcome blood or tissue fluids . As the understanding of the mechanisms and key elements of natural adhesion to aquatic organisms continues to develop, a variety of medical adhesives have been developed by mimicking adhesion procedures or utilizing key functional groups. This article will review the classification, adhesion mechanism, use, research progress and development prospects of biomedical adhesives inspired by aquatic organisms octopus and mussels. Read More

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http://dx.doi.org/10.7507/1001-5515.201805051DOI Listing

[Advances in pathogenic mechanisms of infection].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Mar;31(1):98-104

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.

Angiostrongylosis, a food-borne parasitic disease, is caused by the migration of larvae of to the host's central nervous system after it is infected. It is a serious disease with eosinophilic encephalitis and meningoencephalitis as the main clinical manifestations. Understanding of its pathogenic mechanism is important for the prevention and treatment of angiostrongylosis. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018305DOI Listing

[Advances in etiology, epidemiology and genetic diversity of ].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Mar;31(1):86-93

Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China.

and are three causative agents of human thelaziasis. Most of the reported cases were caused by , occurring in the old world, particularly in Asian and European countries. and have rarely been reported infecting humans in North America. Read More

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http://www.cnki.net/kcms/doi/10.16250/j.32.1374.2018300.html
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http://dx.doi.org/10.16250/j.32.1374.2018300DOI Listing
March 2019
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Optical Coherence Tomography for the Diagnosis and Monitoring of Glaucoma.

Authors:
Ahnul Ha Ki Ho Park

Asia Pac J Ophthalmol (Phila) 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Since its introduction to the field of ophthalmology, optical coherence tomography (OCT) has been markedly improved in terms of imaging protocols, algorithms, and new parameters that have enhanced its utility for the diagnosis and assessment of glaucoma progression. In this review, we examine the clinical utility of OCT in the diagnosis of glaucoma and monitoring of its progression, and emphasize the technological advances that facilitate both glaucoma research and the formulation of clinical management strategies. Read More

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http://dx.doi.org/10.22608/APO.201902DOI Listing

Synthesis of π-functional molecules through oxidation of aromatic amines.

Authors:
Satoru Hiroto

Chem Asian J 2019 Apr 23. Epub 2019 Apr 23.

Kyoto University, Graduate School of Human and Environmental Studies, Yoshidanihonmatsu-cho, Sakyo-ku, 6068501, Kyoto, JAPAN.

In this review, we focus on the synthesis of π-conjugated functional molecules by the oxidation of aromatic amines, which is one of the most effective methods for the construction of C-C, C-N, and N-N bonds between two π-conjugated molecular units, and consider their characteristics and applications. Polyanilines are the most common products of the oxidation of aromatic amines; however, azobenzenes, phenazines, and 1,1'-binaphthyl-2,2'-diamines may be produced in this manner also, depending on the reaction conditions. Recent advances in the methodology of aniline oxidation have led to the development of high-regioselectivity industrial-scale syntheses of optically or electron-active π-functional dyes containing nitrogen atoms. Read More

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http://dx.doi.org/10.1002/asia.201900213DOI Listing

Whole-body MRI of bone marrow: A review.

J Magn Reson Imaging 2019 Apr 23. Epub 2019 Apr 23.

Mater Misericordiae University Hospital, Dublin, Republic of Ireland.

Technical advances in the last two decades have allowed rapid, high-resolution whole-body magnetic resonance imaging (WBMRI). MRI allows unparalleled visualization and detail in the imaging of bone marrow and surrounding soft tissues. The properties of nuclear magnetic resonance allow superb characterization of bone marrow constituents. Read More

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http://dx.doi.org/10.1002/jmri.26759DOI Listing

Progress and gaps in Quebec's autism policy: a comprehensive review and thematic analysis.

Can J Public Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychiatry, Montreal Neurological Institute at McGill University, Montreal, Canada.

Objective: Consistent with a national and global trend, prevalence estimates of autism have risen steadily in Quebec, causing concerns regarding quality and availability of diagnostic and intervention services as well as policies guiding service delivery and their efficacy. We conducted an analysis of Quebec's autism policies to determine recent advances, challenges and gaps in the planning and delivery of provincial autism services.

Methods: We identify autism policy priorities in Quebec through a comprehensive review and a thematic analysis of past and present policies, consider their compliance with national and international human rights and health frameworks and identify policy gaps. Read More

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http://dx.doi.org/10.17269/s41997-019-00202-7DOI Listing

Standardising the Classification of Harm Associated with Medication Errors: The Harm Associated with Medication Error Classification (HAMEC).

Drug Saf 2019 Apr 23. Epub 2019 Apr 23.

Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia.

Classifying harm associated with a medication error can be time consuming and labour intensive and limited studies undertake this step. There is no standardised process, and few studies that report harm assessment provide adequate methods to allow for study replication. Studies typically mention that a clinical review panel classified patient harm and provide a reference to a classification tool. Read More

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http://dx.doi.org/10.1007/s40264-019-00823-4DOI Listing

Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis.

Methods Mol Biol 2019 ;1981:313-323

Division of National Toxicology Program, National Institute of Environmental Health Sciences, Durham, NC, USA.

Cholestasis remains a major challenge in drug-induced liver injury, and therefore warrants identification of chemical entities that may lead to cholestasis. Recent advances in cell culture methods enable 3D spheroid models to remain viable for much longer periods of time than conventional sandwich cultures of primary human hepatocytes while maintaining native tissue-like functionality, such as drug metabolism activity, receptor signaling functionality, and physiological relevance. These spheroid models enable us to study repeated exposure effects associated with chemicals and their metabolites that may ultimately progress to cholestasis and liver injury. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_20DOI Listing
January 2019

The Heterogeneity of Renal Stem Cells and Their Interaction with Bio- and Nano-materials.

Adv Exp Med Biol 2019 ;1123:195-216

Dipartimento di Fisica 'E. Fermi', University of Pisa, Pisa, Italy.

For a long time, the kidney has been considered incapable of regeneration. Instead, in recent years, studies have supported the existence of heterogeneity of renal stem/progenitor cells with the ability to regenerate both glomerular and tubular epithelial cells. Indeed, several studies evidence that renal progenitor cells, releasing chemokines, growth factors, microvesicles, and transcription factors through paracrine mechanisms, can induce tissue regeneration and block pathological processes of the kidney. Read More

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http://link.springer.com/10.1007/978-3-030-11096-3_12
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http://dx.doi.org/10.1007/978-3-030-11096-3_12DOI Listing
January 2019
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Robotic-assisted navigated minimally invasive pedicle screw placement in the first 100 cases at a single institution.

J Robot Surg 2019 Apr 23. Epub 2019 Apr 23.

Musculoskeletal Education and Research Center (MERC), A Division of Globus Medical, Inc., 2560 General Armistead Avenue, Audubon, PA, 19403, USA.

Proper pedicle screw placement is an integral part of spine fusion requiring expertly trained spine surgeons. Advances in medical imaging guidance have improved accuracy. There is high interest in the emerging field of robot-assisted spine surgery; however, safety and accuracy studies are needed. Read More

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http://link.springer.com/10.1007/s11701-019-00959-6
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http://dx.doi.org/10.1007/s11701-019-00959-6DOI Listing
April 2019
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Mechanical Left Ventricular Unloading to Reduce Infarct Size During Acute Myocardial Infarction: Insight from Preclinical and Clinical Studies.

J Cardiovasc Transl Res 2019 Apr 23. Epub 2019 Apr 23.

Division of Cardiology, The University of Texas-Houston Medical School, Houston, TX, USA.

Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality. Pioneering preclinical work reported by Peter Maroko and Eugene Braunwald in 1971 identified oxygen supply and demand are primary determinants of myocardial infarct size in the setting of a heart attack. Since the 1950s, advances in mechanical engineering led to the development of short-term circulatory support devices that range from pulsatile to continuous flow pumps. Read More

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http://dx.doi.org/10.1007/s12265-019-09876-3DOI Listing

Early Detection of Myelodysplastic Syndrome/Leukemia-associated Mutations Using NGS Is Critical in Treating Aplastic Anemia.

Curr Med Sci 2019 Apr 23;39(2):217-221. Epub 2019 Apr 23.

Institution of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Distinguishing between aplastic anemia (AA) and hypoblastic myelodysplastic syndrome (hMDS) with a low percentage of bone marrow (BM) blasts (<5%) can be difficult due to the overlap in clonality and a spectrum of genetic alternations between the two subtypes of diseases. However, due to recent advances in DNA sequencing technology, both spectrum and frequency of mutations can be accurately determined and monitored by next-generation sequencing (NGS) at initial diagnosis and during immunosuppressive therapy (IST) in patients with AA or hMDS. This improvement in acquiring a patient's genetic status and clonal evolution can provide more proper, precise, and on-time information to guide disease management, which is especially helpful in the absence of traditional morphologic/cytogenetic evidence. Read More

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http://dx.doi.org/10.1007/s11596-019-2022-6DOI Listing

A Practical Guide to Biofeedback Therapy for Pelvic Floor Disorders.

Curr Gastroenterol Rep 2019 Apr 23;21(5):21. Epub 2019 Apr 23.

Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street, Rochester, MN, 55905, USA.

Purpose Of Review: Biofeedback therapy (BFT) is effective for managing pelvic floor disorders (i.e., defecatory disorders and fecal incontinence). Read More

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http://dx.doi.org/10.1007/s11894-019-0688-3DOI Listing

EUS-Guided Pancreatic Cyst Ablation: a Clinical and Technical Review.

Curr Gastroenterol Rep 2019 Apr 23;21(5):19. Epub 2019 Apr 23.

Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.

Purpose Of Review: Pancreatic cystic lesions represent a growing public health dilemma, particularly as our population ages and cross-sectional imaging becomes more sensitive. Mucinous cysts carry a clinically significant risk of developing pancreatic cancer, which carries an extremely poor prognosis. Determining which cysts will develop cancer may be challenging, and surgical resection of the pancreas carries significant morbidity. Read More

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http://dx.doi.org/10.1007/s11894-019-0686-5DOI Listing

Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols.

Eur J Nutr 2019 Apr 16. Epub 2019 Apr 16.

Department of Basic and Clinical Sciences, University of Nicosia Medical School, 21 Ilia Papakyriakou, 2414 Engomi, P.O. Box 24005, 1700, Nicosia, Cyprus.

Despite significant advances in the diagnosis and treatment of cancer, the latter still remains a fatal disease due to the lack of prevention, early diagnosis, and effective drugs. Radiotherapy, chemotherapy, and surgery are not only expensive but produce a number of side effects that are detrimental to the patients' quality of life. Therefore, there is a great need to discover anti-cancer therapies that are specific to cancer cells and affordable, safe, and well tolerated by the patients. Read More

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http://dx.doi.org/10.1007/s00394-019-01962-1DOI Listing

Therapeutic antibodies for mantle cell lymphoma: A brand-new era ahead.

Authors:
Ming Sun Han Zhang

Heliyon 2019 Mar 7;5(3):e01297. Epub 2019 Mar 7.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, 650031, China.

Mantle cell lymphoma (MCL) is a heterogeneous aggressive disease and remains incurable with current chemotherapies. The development of monoclonal antibody (mAb) has led to substantial achievement in immunotherapeutic strategies for B-cell lymphomas including MCL. Nonetheless, progress in the clinical use of mAbs is hindered by poor efficacy, off-target toxicities and drug resistance. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475712PMC

The Prevalence and Health Impacts of Frequent Work Discrimination and Harassment among Women Firefighters in the US Fire Service.

Biomed Res Int 2019 20;2019:6740207. Epub 2019 Mar 20.

Institute for Biobehavioral Health Research, National Development & Research Institutes, 1920 W. 143rd Street, Suite 120, Leawood, KS 66224, USA.

Intro: Both discrimination and harassment directly impact mental and physical health. Further, workplace discrimination degrades workplace culture and negatively impacts health behaviors, job-related outcomes, and family dynamics. Women represent a small proportion of the fire service and are often the targets of discrimination/harassment, yet little research documents the impact of such experiences. Read More

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https://www.hindawi.com/journals/bmri/2019/6740207/
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http://dx.doi.org/10.1155/2019/6740207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446094PMC
March 2019
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Safety and Efficacy of Bipolar Radiofrequency Ablation Device in Hemostasis during Thyroidectomy in Comparison with Ultrasonic Scalpel: A Comparative Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):76-80

The Specialized Endocrine and Diabetes Center, Al-Mawani Teaching Hospital, Basra, Iraq.

Aim: Ultrasonic scalpel is one of the recent advances in surgical technology. The main limitation of their use is the cost. However, radiofrequency ablation device is a refined type of electrosurgical cautery that can be used with conventional reusable bipolar cautery forceps. Read More

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http://www.ijem.in/text.asp?2019/23/1/76/254452
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http://dx.doi.org/10.4103/ijem.IJEM_519_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446675PMC
April 2019
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Toward the Application of High Frequency Electromagnetic Wave Absorption by Carbon Nanostructures.

Adv Sci (Weinh) 2019 Apr 10;6(8):1801057. Epub 2019 Feb 10.

State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China.

With the booming development of electronic information technology, the problems caused by electromagnetic (EMs) waves have gradually become serious, and EM wave absorption materials are playing an essential role in daily life. Carbon nanostructures stand out for their unique structures and properties compared with the other absorption materials. Graphene, carbon nanotubes, and other special carbon nanostructures have become especially significant as EM wave absorption materials in the high-frequency range. Read More

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http://dx.doi.org/10.1002/advs.201801057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468972PMC

Disposable Patterned Electroceutical Dressing (PED-10) Is Safe for Treatment of Open Clinical Chronic Wounds.

Adv Wound Care (New Rochelle) 2019 Apr 3;8(4):149-159. Epub 2019 Apr 3.

Department of Surgery, Indiana Center for Regenerative Medicine and Engineering (ICRME), Indiana University School of Medicine, Indianapolis, Indiana.

To evaluate if patterned electroceutical dressing (PED) is safe for human chronic wounds treatment as reported by wound care providers. This work reports a pilot feasibility study with the primary objective to determine physically observable effects of PED application on host tissue response from a safety evaluation point of view. For this pilot study, patients receiving a lower extremity amputation with at least one open wound on the part to be amputated were enrolled. Read More

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http://dx.doi.org/10.1089/wound.2018.0915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477589PMC

Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration.

J Ophthalmol 2019 19;2019:5743109. Epub 2019 Mar 19.

Eye Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, Jilin 130021, China.

Retinal degenerative diseases are a leading cause of visual impairment or blindness. There are many therapies for delaying the progression of vision loss but no curative strategies currently. Stimulating intrinsic neuronal regeneration is a potential approach to therapy in retinal degenerative diseases. Read More

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http://dx.doi.org/10.1155/2019/5743109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444254PMC

miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.

Cell Death Discov 2019 15;5:89. Epub 2019 Apr 15.

1Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, 116044 Dalian, China.

Clear cell renal cell carcinoma (ccRCC) is the most aggressive RCC subtype with high metastasis, chemotherapy and radiotherapy resistance, and poor prognosis. This study attempted to establish the deregulations of miR-4521 and FAM129A together with their correlation to and mechanism of regulation of ccRCC development and progression. FAM129A acted as tumor promotor and miR-4521 acted as a suppressor in ccRCC. Read More

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http://dx.doi.org/10.1038/s41420-019-0167-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465337PMC

Is the incidence of survival in interior Pleistocene refugia (nunataks) underestimated? Phylogeography of the high mountain plant (Primulaceae) in the European Alps revisited.

Ecol Evol 2019 Apr 7;9(7):4078-4086. Epub 2019 Mar 7.

Department of Botany and Biodiversity Research University of Vienna Vienna Austria.

Temperate mountain ranges such as the European Alps have been strongly affected by the Pleistocene glaciations. Glacial advances forced biota into refugia, which were situated either at the periphery of mountain ranges or in their interior. Whereas in the Alps peripheral refugia have been repeatedly and congruently identified, support for the latter scenario, termed "nunatak hypothesis," is still limited and no general pattern is recognizable yet. Read More

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http://dx.doi.org/10.1002/ece3.5037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468090PMC

Modular genetic design of multi-domain functional amyloids: insights into self-assembly and functional properties.

Chem Sci 2019 Apr 15;10(14):4004-4014. Epub 2019 Feb 15.

School of Physical Science and Technology , ShanghaiTech University , Shanghai 200120 , China . Email:

Engineering functional amyloids through a modular genetic strategy represents new opportunities for creating multifunctional molecular materials with tailored structures and performance. Despite important advances, how fusion modules affect the self-assembly and functional properties of amyloids remains elusive. Here, using curli as a model system, we systematically studied the effect of flanking domains on the structures, assembly kinetics and functions of amyloids. Read More

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http://dx.doi.org/10.1039/c9sc00208aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461117PMC

CatbNet: A Multi Network Analyzer for Comparing and Analyzing the Topology of Biological Networks.

Curr Genomics 2019 Jan;20(1):69-75

Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

Background: Complexity and dynamicity of biological events is a reason to use comprehen-sive and holistic approaches to deal with their difficulty. Currently with advances in omics data genera-tion, network-based approaches are used frequently in different areas of computational biology and bio-informatics to solve problems in a systematic way. Also, there are many applications and tools for net-work data analysis and manipulation which their goal is to facilitate the way of improving our under-standings of inter/intra cellular interactions. Read More

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http://dx.doi.org/10.2174/1389202919666181213101540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446483PMC
January 2019

Molecular assay for an intronic variant in NUP93 that causes steroid resistant nephrotic syndrome.

J Hum Genet 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Advances in molecular genetics have revealed that approximately 30% of cases with steroid-resistant nephrotic syndrome (SRNS) are caused by single-gene mutations. More than 50 genes are responsible for SRNS. One such gene is the nucleoporin, 93-KD (NUP93). Read More

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http://dx.doi.org/10.1038/s10038-019-0606-4DOI Listing

Fertilizer management and soil type influence grain zinc and iron concentration under contrasting smallholder cropping systems in Zimbabwe.

Sci Rep 2019 Apr 23;9(1):6445. Epub 2019 Apr 23.

Soil Fertility Consortium for Southern Africa (SOFECSA), Department of Soil Science and Agricultural Engineering, University of Zimbabwe, Harare, Zimbabwe.

Micronutrient deficiencies remain prevalent in food systems of southern Africa, although advances in biofortification through crop breeding and agronomy provide opportunities to address these. We determined baseline soil availability of zinc (Zn) and iron (Fe) and the effects of soil type and farmer management on extractable soil Zn and Fe and subsequent concentration in cereal and legume grains under two contrasting agro-ecologies in Zimbabwe. Soil and crop surveys were conducted in Hwedza and Mutasa Districts of Zimbabwe in 2015-16 on 350 locations over different soil types. Read More

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http://dx.doi.org/10.1038/s41598-019-42828-0DOI Listing