250,076 results match your criteria Advances in Anatomy Embryology and Cell Biology [Journal]


Extracellular vesicle-mediated crosstalk between melanoma and the immune system: Impact on tumor progression and therapy response.

J Leukoc Biol 2020 May 25. Epub 2020 May 25.

Program of Immunology and Tumor Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.

Melanoma is a very lethal tumor type that easily spreads and colonizes regional and distant tissues. Crucial phenotypic changes that favor melanoma metastasis are interposed by the tumor microenvironment (TME), representing a complex network in which malignant cells communicate not only with each other but also with stromal and immune cells. This cell-cell communication can be mediated by extracellular vesicles (EVs), which are lipid bilayer-delimited particles capable of carrying a wide variety of bioactive compounds. Read More

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http://dx.doi.org/10.1002/JLB.3MR0320-644RDOI Listing

Classic and targeted anti-leukaemic agents interfere with the cholesterol biogenesis metagene in acute myeloid leukaemia: Therapeutic implications.

J Cell Mol Med 2020 May 25. Epub 2020 May 25.

Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.

Despite significant advances in deciphering the molecular landscape of acute myeloid leukaemia (AML), therapeutic outcomes of this haematological malignancy have only modestly improved over the past decades. Drug resistance and disease recurrence almost invariably occur, highlighting the need for a deeper understanding of these processes. While low O compartments, such as bone marrow (BM) niches, are well-recognized hosts of drug-resistant leukaemic cells, standard in vitro studies are routinely performed under supra-physiologic (21% O , ambient air) conditions, which limits clinical translatability. Read More

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http://dx.doi.org/10.1111/jcmm.15339DOI Listing

Small Cell Lung Cancer: Advances in Diagnosis and Management.

Semin Respir Crit Care Med 2020 Jun 25;41(3):435-446. Epub 2020 May 25.

Division of Medical Oncology, Georgetown University, Washington, District of Columbia, Washington, DC.

Small cell lung cancer (SCLC) is an aggressive subtype of lung cancer characterized by rapid growth and early spread. It is a highly lethal disease that typically is diagnosed at a late stage. Surgery plays a very small role in this cancer, and management typically involves chemotherapy, delivered with thoracic radiation in early-stage disease. Read More

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http://dx.doi.org/10.1055/s-0039-1700566DOI Listing

Lung Cancer: Advances in Diagnosis and Management.

Semin Respir Crit Care Med 2020 Jun 25;41(3):333-334. Epub 2020 May 25.

Section of Thoracic Surgery, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1055/s-0040-1709995DOI Listing

Recent advances and challenges of immune checkpoint inhibitors in immunotherapy of non-small cell lung cancer.

Int Immunopharmacol 2020 May 21;85:106613. Epub 2020 May 21.

Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address:

Chemotherapy and targeted therapy have significantly improved the progression of non-small cell lung cancer (NSCLC), but patients are inevitably suffering from drug resistance and relapse. With this background, the immunotherapy brings a turnaround for a subset of cancer patients. Over two decades, with the development of immunotherapy, immune checkpoint inhibitors (ICIs) have made a breakthrough in NSCLC patients. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106613DOI Listing

Implications of nonlinearity, confounding, and interactions for estimating exposure concentration-response functions in quantitative risk analysis.

Environ Res 2020 May 19;187:109638. Epub 2020 May 19.

University of Colorado, USA. Electronic address:

Recent advances in understanding of biological mechanisms and adverse outcome pathways for many exposure-related diseases show that certain common mechanisms involve thresholds and nonlinearities in biological exposure concentration-response (C-R) functions. These range from ultrasensitive molecular switches in signaling pathways, to assembly and activation of inflammasomes, to rupture of lysosomes and pyroptosis of cells. Realistic dose-response modeling and risk analysis must confront the reality of nonlinear C-R functions. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109638DOI Listing

Downstream processing technologies in the biocatalytic production of oligosaccharides.

Biotechnol Adv 2020 May 22:107568. Epub 2020 May 22.

Austrian Centre of Industrial Biotechnology (acib), Krenngasse 37, 8010 Graz, Austria; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Petersgasse 12, 8010 Graz, Austria. Electronic address:

Oligosaccharides are important ingredients for food and feed products. There has therefore been much interest in the development of biocatalytic processes for their production. Irrespective of the oligosaccharide manufacturing route, that is, bottom-up synthesis or controlled depolymerization of a polysaccharide, isolating the product from the reaction mixture usually presents a considerable challenge. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2020.107568DOI Listing

Pyridine and quinoline molecules as crucial protagonists in the never-stopping discovery of new agents against tuberculosis.

Eur J Pharm Sci 2020 May 22:105374. Epub 2020 May 22.

Laboratorio de Química Orgánica y Biomolecular, CMN, Universidad Industrial de Santander, Parque Tecnológico Guatiguará, Piedecuesta 681011, Colombia. Electronic address:

Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly 1.6 million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis (Mtb), which causes TB, was identified more than 130 years ago, nowadays only old vaccine (Bacillus Calmette-Guérin vaccine) and classical toxic drugs that are losing its effectiveness are available in clinic practice. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105374DOI Listing

Evolution in Crop Improvement Approaches and Future Prospects of Molecular Markers to CRISPR/Cas9 System.

Gene 2020 May 22:144795. Epub 2020 May 22.

Department of Biotechnology, School of Basic and Applied Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, India.

The advent of genetic selection and genome modification method assure about a real novel reformation in biotechnology and genetic engineering. With the extensive capabilities of molecular markers of them being stable, cost-effective and easy to use, they ultimately become a potent tool for variety of applications such a gene targeting, selection, editing, functional genomics; mainly for the improvisation of commercially important crops. Three main benefits of molecular marker in the field of agriculture and crop improvement programmes first, reduction of the duration of breeding programmes, second, they allow creation of new genetic variation and genetic diversity of plants and third most promising benefit is help in production of engineered plant for disease resistance, or resistance from pathogen and herbicides. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144795DOI Listing

Peripheral and cerebral abnormalities of the tryptophan metabolism in the depression-like rats induced by chronic unpredicted mild stress.

Neurochem Int 2020 May 22:104771. Epub 2020 May 22.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China. Electronic address:

Tryptophan (TRP) metabolism could occur both peripherally and centrally, which plays an essential role in brain and gastrointestinal disorders. The participation of TRP metabolism in the bidirectional brain-gut interactions is of value to better understand the mechanism of the pathophysiology of depression. To compare the difference between peripheral and cerebral TRP metabolism in depression, the chronic unpredicted mild stress (CUMS) was used to induce depressive-like syndrome in rats. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104771DOI Listing

Uveal melanoma pathobiology: metastasis to the liver.

Semin Cancer Biol 2020 May 22. Epub 2020 May 22.

Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, Canada; Experimental Pathology Unit, Department of Pathology, McGill University, Montréal, Canada; Gerald Bronfman Department Of Oncology, McGill University, Montréal, Canada. Electronic address:

Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the liver. Despite the identification of the early driver mutations during the development of the pathology, the process of UM metastasis is still not fully comprehended. A better understanding of the genetic, molecular, and environmental factors participating to its spread and metastatic outgrowth could provide additional approaches for UM treatment. Read More

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http://dx.doi.org/10.1016/j.semcancer.2020.05.003DOI Listing

Membrane-core nanoparticles for cancer nanomedicine.

Adv Drug Deliv Rev 2020 May 22. Epub 2020 May 22.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

Cancer is one of the most severe disease burdens in modern times, with an estimated increase in the number of patients diagnosed globally from 18.1 million in 2018 to 23.6 million in 2030. Read More

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http://dx.doi.org/10.1016/j.addr.2020.05.005DOI Listing

The Human Lacrimal Gland: Historical Perspectives, Current Understanding and Recent Advances.

Curr Eye Res 2020 May 25. Epub 2020 May 25.

Centre for Ocular Regeneration (CORE), L V Prasad Eye Institute , Hyderabad, Telangana, India.

The lacrimal glands produce the aqueous component of the pre-ocular tear film, which is essential for ocular health and optimal vision. This review explores its history, current understanding and recent advances, and scope for future research. It traces the evolution of human knowledge about the source of tears across several millennia, with specific emphasis on the individuals who made seminal contributions to this field. Read More

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http://dx.doi.org/10.1080/02713683.2020.1774065DOI Listing

Biosynthetic Approaches Towards the Design of Artificial Hydrogen Evolution Catalysts.

Chemistry 2020 May 25. Epub 2020 May 25.

University of Mississippi, Chemistry, 305 Coulter Hall, 38655, University, UNITED STATES.

Hydrogen is a clean and sustainable form of fuel that can minimize our heavy dependence on fossil fuels as the primary energy source. The need of finding greener ways to generate H 2 gas has ignited interest in the research community to synthesize catalysts that can produce H 2 gas by the reduction of H + . The natural H 2 producing enzymes hydrogenases have served as an inspiration to produce catalytic metal centers akin to these native enzymes. Read More

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http://dx.doi.org/10.1002/chem.202001338DOI Listing

Skull osteology and osteological phylogeny of the Western whip snake Hierophis viridiflavus (Squamata, Colubridae).

J Morphol 2020 May 25. Epub 2020 May 25.

Dipartimento di Scienze della Terra, Università di Torino, Torino, Italy.

The skull osteology of Hierophis viridiflavus is here described and figured in detail on the basis of 18 specimens. The sample includes specimens from the ranges of both H. viridiflavus viridiflavus and H. Read More

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http://dx.doi.org/10.1002/jmor.21148DOI Listing

New and future perspectives for parathyroid carcinoma.

Endocr Relat Cancer 2020 May 1. Epub 2020 May 1.

M Brandi, Surgery and Translational Medicine, University of Florence, Firenze, Italy.

This report summarizes published data on parathyroid cancer, with the inclusion of topics discussed at the 16th International Workshop on Multiple Endocrine Neoplasia (MEN2019), 27-29 March 2019, Houston, TX, USA. An expert panel on parathyroid cancer was constituted by the steering committee to address key questions in the field. The objectives were to recap open forum discussion of interested parties from multiple disciplines. Read More

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http://dx.doi.org/10.1530/ERC-20-0018DOI Listing

A perspective on modern advances for COVID-19 (SARS-CoV-2) therapeutics.

Eur J Rheumatol 2020 May 22. Epub 2020 May 22.

Division of Rheumatology, UCLA School of Medicine, Los Angeles, CA, USA.

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http://dx.doi.org/10.5152/eurjrheum.2020.2065DOI Listing

Current survey of early childhood intervention services in infants and young children with sex chromosome aneuploidies.

Am J Med Genet C Semin Med Genet 2020 May 25. Epub 2020 May 25.

Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Sex chromosome aneuploidies (SCAs) are the most commonly occurring aneuploidies in children with a collective prevalence rate of 1 in 500 live births. Prior research has documented SCAs are associated with an increased risk for early expressive language and gross motor delays, learning disorders, ADHD, autism spectrum disorder, anxiety, and executive function problems. Although SCAs have been historically underdiagnosed in young children, recent advances in noninvasive prenatal testing have resulted in an increasing nationwide cohort of infants with confirmed diagnoses. Read More

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http://dx.doi.org/10.1002/ajmg.c.31785DOI Listing

Aromatase inhibitors: Role in postmenopausal breast cancer.

Arch Pharm (Weinheim) 2020 May 25:e2000081. Epub 2020 May 25.

Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed-to-be-University), New Delhi, India.

Postmenopausal women are at high risk of developing breast cancer due to estrogen production in peripheral tissues of the body other than ovaries. Aromatase is present in breast tissue, leading to local estrogen production which can be inhibited by a variety of steroidal and nonsteroidal aromatase inhibitors. There are many aromatase inhibitors available in clinical practice like exemestane, formestane, anastrozole, letrozole, fadrozole, vorozole, and so forth, but the major challenge in anti-breast cancer therapy is the toxicity associated with aromatase inhibitors, especially the steroidal class of drugs. Read More

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http://dx.doi.org/10.1002/ardp.202000081DOI Listing

Collector Channels: Role and Evaluation in Schlemm's Canal Surgery.

Curr Eye Res 2020 May 23. Epub 2020 May 23.

Department of Ophthalmology, Kasr Al-Ainy, Cairo University .

Objectives: 1) To elucidate the role of collector channels in the aqueous humor outflow pathway 2) To suggest anatomic and functional methods of imaging collector channels in-vitro and in-vivo and 3) To discuss the role of such imaging modalities in the surgical management of glaucoma.

Methods: A thorough literature search was conducted on databases for studies published in English regarding the available methods to determine the role of collecting channels in normal and glaucomatous patients and to assess their patency.

Results: Intraocular pressure (IOP) exists as a balance between aqueous humor production and aqueous humor outflow. Read More

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http://dx.doi.org/10.1080/02713683.2020.1773866DOI Listing

Size-Dependent Pt-TiO Strong Metal-Support Interaction.

J Phys Chem Lett 2020 May 23. Epub 2020 May 23.

Strong metal-support interaction (SMSI) is one of the most important concepts in heterogeneous catalysis. Herein we report a study of Pt-TiO2 SMSI using Pt/rutile TiO2(110) model catalysts with different Pt particle sizes with x-ray photoelectron spectroscopy, ion scattering spectroscopy, and adsorption of probe molecules. The acquired results unambiguously demonstrate a size dependence of the Pt-TiO2 SMSI, in which SMSI occurs barely between supported Pt clusters and TiO2(110) substrate, but obviously between supported Pt nanoparticles and TiO2(110) substrate. Read More

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http://dx.doi.org/10.1021/acs.jpclett.0c01560DOI Listing

Biomaterials against Bone Infection.

Adv Healthc Mater 2020 May 25:e2000310. Epub 2020 May 25.

Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, Madrid, 28040, Spain.

Chronic bone infection is considered as one of the most problematic biofilm-related infections. Its recurrent and resistant nature, high morbidity, prolonged hospitalization, and costly medical care expenses have driven the efforts of the scientific community to develop new therapies to improve the standards used today. There is great debate on the management of this kind of infection in order to establish consistent and agreed guidelines in national health systems. Read More

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http://dx.doi.org/10.1002/adhm.202000310DOI Listing

Systemic effects of mitochondrial stress.

EMBO Rep 2020 May 24:e50094. Epub 2020 May 24.

Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.

Multicellular organisms are complex biological systems, composed of specialized tissues that require coordination of the metabolic and fitness state of each component. In the cells composing the tissues, one central organelle is the mitochondrion, a compartment essential for many energetic and fundamental biological processes. Beyond serving these functions, mitochondria have emerged as signaling hubs in biological systems, capable of inducing changes to the cell they are in, to cells in distal tissues through secreted factors, and to overall animal physiology. Read More

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http://dx.doi.org/10.15252/embr.202050094DOI Listing

Beyond Frameworks: Structuring Reticular Materials across Nano, Meso, and Bulk Regimes.

Angew Chem Int Ed Engl 2020 May 24. Epub 2020 May 24.

Ludwig-Maximilians Universität München, Department Chemie, Butenandtstr. 11, Haus E, E 3.039, 81377, Munich, GERMANY.

Reticular materials are of high interest for diverse applications ranging from catalysis and separation to gas storage and drug delivery. These open, extended frameworks can be tailored to the intended application through crystal structure design. Implementing these materials in application settings, however, requires structuring beyond their lattices, in order to interface the functionality at the molecular level effectively with the macroscopic world. Read More

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http://dx.doi.org/10.1002/anie.201914461DOI Listing

The Use of Artificial Intelligence and Deep Machine Learning in Oncologic Histopathology.

J Oral Pathol Med 2020 May 24. Epub 2020 May 24.

School of Dentistry, University of Maryland, Baltimore, MD, 21201, USA.

Background: Recently, there has been a momentous drive to apply advanced artificial intelligence (AI) technologies to diagnostic medicine. The introduction of AI has provided vast new opportunities to improve healthcare and has introduced a new wave of heightened precision in oncologic pathology. The impact of AI on oncologic pathology has now become apparent and its use with respect to oral oncology is still in the nascent stage. Read More

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http://dx.doi.org/10.1111/jop.13042DOI Listing

Management of Diabetic Ketoacidosis in Children and Adolescents with Type 1 Diabetes Mellitus.

Paediatr Drugs 2020 May 25. Epub 2020 May 25.

Division of Pediatric Endocrinology and Pediatric Diabetes Center, Massachusetts General Hospital, 175 Cambridge Street, 5th Floor, Boston, MA, 02114, USA.

Diabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes mellitus (T1D). Loss of insulin production leads to profound catabolism with increased gluconeogenesis, glycogenolysis, lipolysis, and muscle proteolysis causing hyperglycemia and osmotic diuresis. High levels of counter-regulatory hormones lead to enhanced ketogenesis and the release of 'ketone bodies' into the circulation, which dissociate to release hydrogen ions and cause an overwhelming acidosis. Read More

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http://dx.doi.org/10.1007/s40272-020-00397-0DOI Listing

Metabolism and growth adaptation to environmental conditions in Drosophila.

Cell Mol Life Sci 2020 May 24. Epub 2020 May 24.

Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Organisms adapt to changing environments by adjusting their development, metabolism, and behavior to improve their chances of survival and reproduction. To achieve such flexibility, organisms must be able to sense and respond to changes in external environmental conditions and their internal state. Metabolic adaptation in response to altered nutrient availability is key to maintaining energy homeostasis and sustaining developmental growth. Read More

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http://dx.doi.org/10.1007/s00018-020-03547-2DOI Listing

Diagnostic patterns in keratoconus.

Cont Lens Anterior Eye 2020 May 21. Epub 2020 May 21.

Department of Ophthalmology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium; Faculty of Medicine and Medical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.

Purpose: To investigate the current patterns of diagnosis and referral in keratoconus.

Methods: A retrospective chart review was performed of patients who had recently been diagnosed with keratoconus and attended dedicated clinics at Antwerp University Hospital, Belgium and Maria Middelares General Hospital, Ghent, Belgium between June 2013 and February 2018. Exclusion criteria included longstanding keratoconus diagnosis, reduced cognitive capabilities and prior surgical procedures (corneal crosslinking, penetrating keratoplasty or any type of refractive surgery). Read More

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http://dx.doi.org/10.1016/j.clae.2020.05.002DOI Listing

Nanotherapeutics for Antimetastatic Treatment.

Trends Cancer 2020 May 21. Epub 2020 May 21.

Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Tumor metastases, that is, the development of secondary tumors in organs distant from the primary tumor, and their treatment remain a serious problem in cancer therapy. The unique challenges for tracking and treating tumor metastases lie in the small size, high heterogeneity, and wide dispersion to distant organs of metastases. Recently, nanomedicines, with the capacity to precisely deliver therapeutic agents to both primary and secondary tumors, have demonstrated many potential benefits for metastatic cancer theranostics. Read More

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http://dx.doi.org/10.1016/j.trecan.2020.05.001DOI Listing

Site-specific radioiodination of an anti-HER2 single domain antibody fragment with a residualizing prosthetic agent.

Nucl Med Biol 2020 May 12. Epub 2020 May 12.

Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

Introduction: As a consequence of their small size, high stability and high affinity, single domain antibody fragments (sdAbs) are appealing targeting vectors for radiopharmaceutical development. With sdAbs binding to internalizing receptors like HER2, residualizing prosthetic agents can enhance tumor retention of radioiodine, which until now has been done with random labeling approaches. Herein we evaluate a site-specific strategy utilizing a radioiodinated, residualizing maleimido moiety and the anti-HER2 sdAb 5F7 bearing a GGC tail for conjugation. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2020.05.002DOI Listing

New advances on the inhibition of Siwei Xiaoliuyin combined with Temozolomide in glioma based on the regulatory mechanism of miRNA21/221.

Int Rev Neurobiol 2020 13;151:99-110. Epub 2020 May 13.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, S-75185 Uppsala, Sweden.

Objective: To provide evidence for the mechanism of Chinese medicine to treat glioma. We observe the effects of Si wei xiao xiu yin combined with chemotherapy on the growth of subcutaneous xenografts in nude mice and the expression of miRNA-21 and miRNA-221 in tumor tissues.

Methods: The subcutaneous transplantation model of nude mice was established by subcutaneous inoculation of glioma U87 cell suspension. Read More

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http://dx.doi.org/10.1016/bs.irn.2020.03.003DOI Listing

Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine.

Int Rev Neurobiol 2020 13;151:1-66. Epub 2020 May 13.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, S-75185 Uppsala, Sweden; LaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain. Electronic address:

Glioblastoma Multiforme (GBM) is one the most common intracranial tumors discovered by Burns (1800) and Abernethy (1804) based on gross morphology of the autopsied material and referred to as "medullary sarcoma" and later "fungus medullare" (Abernethy, 1804; Burns, 1800). Virchow in 1863 was the first German pathologist using histomorphological techniques discovered that GBM is a tumor of glial origin. Virchow (1863/65) also then used the term Glioma for the first time and classified as low-grade glioma and high-grade glioma very similar to that of today according to World health organization (WHO) classification (Jellinger, 1978; Virchow, 1863/65). Read More

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http://dx.doi.org/10.1016/bs.irn.2020.03.001DOI Listing

Imaging of Neuromyelitis Optica Spectrum Disorders.

Authors:
Sheng-Che Hung

Semin Ultrasound CT MR 2020 Jun 10;41(3):319-331. Epub 2020 Mar 10.

Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:

Neuromyelitis optica (NMO) is a rare and chronic disabling autoimmune astrocytopathy of the central nervous system. Current advances regarding aquaporin-4 antibody function facilitate the understanding of clinical manifestations and imaging findings beyond optic neuritis and transverse myelitis. The current definition of NMO spectrum disorder (NMOSD) includes both aquaporin-4-IgG seropositive and seronegative patients who present with characteristic findings. Read More

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http://dx.doi.org/10.1053/j.sult.2020.02.006DOI Listing

Advances in extracellular vesicles analysis.

Adv Clin Chem 2020 17;97:73-116. Epub 2020 Feb 17.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. Electronic address:

Extracellular vesicles (EVs) play an important role in intercellular communication in normal cellular process and pathological conditions by facilitating the transport of cellular content from one cell to another. EVs as conveyors of various biological molecules with their ability to redirect effects on a target cell physiological function in cell type-specific manner makes EVs an excellent candidate for drug delivery vehicle in disease therapy. Moreover, unique characteristics and contents of EVs which differ depends on cellular origin and physiological state make them a valuable source of diagnostic biomarker. Read More

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http://dx.doi.org/10.1016/bs.acc.2019.12.003DOI Listing
February 2020

Long non-coding RNA HOTAIR in cervical cancer: Molecular marker, mechanistic insight, and therapeutic target.

Adv Clin Chem 2020 8;97:117-140. Epub 2020 Feb 8.

Xiangya Nursing School, Central South University, Changsha, Hunan, China. Electronic address:

Cervical cancer is a common gynecologic malignant tumor with high mortality. HOX transcript antisense RNA (HOTAIR), a trans-acting long non-coding RNA (lncRNA) containing six exons in humans, is transcribed from the antisense strand of homeobox gene C cluster. This lncRNA serves as a modular scaffold for gene silencing and protein ubiquitination. Read More

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http://dx.doi.org/10.1016/bs.acc.2019.12.004DOI Listing
February 2020

Emerging therapeutic agents for advanced non-small cell lung cancer.

J Hematol Oncol 2020 May 24;13(1):58. Epub 2020 May 24.

Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, 32224, USA.

Advanced non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with a poor prognosis and no known cure. Survival time is often short because of limited treatment options. Recent advances in targeted therapy and immunotherapy have changed the landscape for the treatment of advanced NSCLC. Read More

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http://dx.doi.org/10.1186/s13045-020-00881-7DOI Listing

Biomarker-driven management strategies for peripheral T cell lymphoma.

J Hematol Oncol 2020 May 24;13(1):59. Epub 2020 May 24.

Meyer Cancer Center, Weill Cornell Medicine, 1305 York Avenue, 7th Floor, New York, NY, 10021, USA.

Peripheral T cell lymphomas are heterogeneous diseases which remain treatment challenges. Recent advances in molecular and genomic profiling have provided unprecedented insight into disease pathogenesis driven by distinct cells of origins and molecular pathways. The discovery and clinical application of molecular biomarkers in PTCL subtypes has the potential to transform personalized care for patients with PTCL in diagnosis, prognosis, and therapy. Read More

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http://dx.doi.org/10.1186/s13045-020-00889-zDOI Listing

Role of social and other determinants of health in the effect of a multicomponent integrated care strategy on type 2 diabetes mellitus.

Int J Equity Health 2020 May 24;19(1):75. Epub 2020 May 24.

Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología - Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, San Fernando 22, Colonia Sección XVI, Tlalpan, 14080, Mexico City, Mexico.

Background: Although important advances in treatment strategies have been developed in type 2 diabetes mellitus (T2DM), large gaps exist in achieving glycemic control and preventing complications, particularly in low-and middle-income countries, which suggests a potential effect of social determinants of health (SDH, i.e., education level and socioeconomic status). Read More

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http://dx.doi.org/10.1186/s12939-020-01188-2DOI Listing

Recent advances in herbal nanomedicines for cancer treatment.

Curr Mol Pharmacol 2020 May 24. Epub 2020 May 24.

Department of Pharmacognosy, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha. India.

Cancer continues to be one of the deadliest diseases that adversely impacts the large population of the world. A stack of scientific documents reflects a huge number of potent plant-based anticancer drugs such as curcumin (CUR), podophyllotoxin, camptothecin (CPT), vincristine, vinblastine, paclitaxel (PTX), etc. that have been integrated into the modern practice of cancer treatment. Read More

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http://dx.doi.org/10.2174/1874467213666200525010624DOI Listing

Recent Advances and Applications of Microfluidic Capillary Electrophoresis: A Comprehensive Review (2017-Mid 2019).

Crit Rev Anal Chem 2020 May 24:1-33. Epub 2020 May 24.

Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, Alexandria University, El-Messalah, Alexandria, Egypt.

Microfluidic capillary electrophoresis (MCE) is the novel technique resulted from the CE mininaturization as planar separation and analysis device. This review presents and discusses various application fields of this advanced technology published in the period 2017 till mid-2019 in eight different sections including clinical, biological, single cell analysis, environmental, pharmaceuticals, food analysis, forensic and ion analysis. The need for miniaturization of CE and the consequence advantages achieved are also discussed including high-throughput, miniaturized detection, effective separation, portability and the need for micro- or even nano-volume of samples. Read More

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http://dx.doi.org/10.1080/10408347.2020.1765729DOI Listing

Temperature-independent polarization of ultrathin phthalocyanine-based hybrid organic/inorganic heterojunctions.

ACS Appl Mater Interfaces 2020 May 25. Epub 2020 May 25.

The combination of organic and inorganic materials at the nanoscale to form functional hybrid structures is a powerful strategy to develop novel electronic devices. The knowledge on semiconductor thin-film polarization brings direct benefits to the hybrid organic/inorganic electronics, becoming primordial for the development of devices such as electromechanical logic gates, solar cells, miniaturized valves, organic diodes, molecular supercapacitors, among others. Here we report on the dielectric polarization of ultrathin organic semiconducting films - ca. Read More

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http://dx.doi.org/10.1021/acsami.0c02067DOI Listing

[Advances on mouse transplantation model of myelodysplastic syndrome].

Authors:
Y Fang C K Chang

Zhonghua Xue Ye Xue Za Zhi 2020 Apr;41(4):344-347

Department of Hematology, Shanghai JiaoTong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.04.017DOI Listing

Is it ductal carcinoma in situ with microinvasion or "Ductogenesis"? The role of myoepithelial cell markers.

Authors:
Shahla Masood

Breast J 2020 May 23. Epub 2020 May 23.

Department of Pathology, University of Florida College of Medicine - Jax, Jacksonville, FL, USA.

Mammary myoepithelial cells have been under-recognized for many years since they were considered less important in breast cancer tumorigenesis compared to luminal epithelial cells. However, in recent years with advances in genomics, cell biology, and research in breast cancer microenvironment, more emphasis has been placed on better understanding of the role that myoepithelial cells play in breast cancer progression. As the result, it has been recognized that the presence or absence of myoepithelial cells play a critical role in the assessment of tumor invasion in diagnostic breast pathology. Read More

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http://dx.doi.org/10.1111/tbj.13897DOI Listing

TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development.

Cell Mol Life Sci 2020 May 23. Epub 2020 May 23.

NHC Key Laboratory of Carcinogenesis, Hunan Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from various organs. TP63 is a master regulator that plays an essential role in epidermal differentiation. It is also a lineage-dependent oncogene in SCC. Read More

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http://dx.doi.org/10.1007/s00018-020-03539-2DOI Listing

Medical treatment in thyroid eye disease in 2020.

Br J Ophthalmol 2020 May 23. Epub 2020 May 23.

Department of Surgery, University of Melbourne, Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia.

Thyroid eye disease (TED) affects 25% of patients with Graves' hyperthyroidism, where 1 in 20 patients has active, moderate-to-severe disease that will require medical treatment for reducing TED activity and severity. Intravenous corticosteroid has been the mainstay of treatment for active moderate-to-severe TED. With improved understanding of the pathophysiology of TED, immunotherapy targeting different molecular pathways including T cells, B cells, cytokines and cell surface receptors have been investigated in randomised clinical trials. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316051DOI Listing

Conflict-related sexual violence: a review.

Authors:
Ela Stachow

BMJ Mil Health 2020 Jun 29;166(3):183-186. Epub 2020 Jan 29.

Academic Department of Military General Practice, Research and Clinical Innovation, Royal Centre for Defence Medicine, Birmingham, UK

Conflict-related sexual violence (CRSV) is a concerning yet prevalent feature of historical and current conflict. The term encompasses any form of sexual violence associated with conflict, including rape, sexual assault and forced marriage or prostitution. Acts of CRSV have been perpetrated by both military personnel and civilians against men, women and children. Read More

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http://dx.doi.org/10.1136/jramc-2019-001376DOI Listing

BMP gene delivery for skeletal tissue regeneration.

Bone 2020 May 21:115449. Epub 2020 May 21.

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address:

Musculoskeletal disorders are common and can be associated with significant morbidity and reduced quality of life. Current treatments for major bone loss or cartilage defects are insufficient. Bone morphogenetic proteins (BMPs) are key players in the recruitment and regeneration of damaged musculoskeletal tissues, and attempts have been made to introduce the protein to fracture sites with limited success. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115449DOI Listing

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [F]fluorophenylglutamine and [F]fluorobiphenylglutamine.

Nucl Med Biol 2020 Apr 3;86-87:20-29. Epub 2020 Apr 3.

Department of Chemistry and Biochemistry, University of Arkansas, AR, USA. Electronic address:

Introduction: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis. The development of radiolabeled glutamine derivatives could be a useful molecular imaging tool for visualizing these tumors. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2020.03.006DOI Listing

Biomimetic and Bioinspired Silicifications: Recent Advances for Biomaterial Design and Applications.

Acta Biomater 2020 May 21. Epub 2020 May 21.

Department of Biotechnology and Bioinformatics, Korea University, Sejong-Ro 2511, Sejong, 30019, Republic of Korea. Electronic address:

The rational design and controllable synthesis of functional silica-based materials have gained increased interest in a variety of biomedical and biotechnological applications due to their unique properties. The current review shows that marine organisms, such as siliceous sponges and diatoms, could be the inspiration for the fabrication of advanced biohybrid materials. Several biomolecules were involved in the molecular mechanism of biosilicification in vivo. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.017DOI Listing

Advances in imaging and analysis of 4 fluorescent components through the rat cortical column.

J Neurosci Methods 2020 May 21:108792. Epub 2020 May 21.

Biomedical Engineering Creative Laboratory, Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA. Electronic address:

Background Immunofluorescent staining coupled with axial optical sectioning allows for assessment of native three-dimensional structure of brain tissue. Typical challenges of analyzing network structure include limitations driven by magnification/field of view, spatial resolution, tissue thickness, staining quality of dense cell types, data quantifiability and the quantity of simultaneous staining targets. New Method This manuscript demonstrates many methodological advancements. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2020.108792DOI Listing