223,127 results match your criteria Advances in Anatomic Pathology[Journal]


Discovery and development of small molecule modulators targeting glutamine metabolism.

Eur J Med Chem 2018 Nov 28;163:215-242. Epub 2018 Nov 28.

Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:

Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent on the glycolysis pathway and other atypical metabolic characteristics such as increased fatty acid synthesis and increased rates of glutamine metabolism. Among these metabolic features of cancers, glutamine metabolism has been reported to be the main energy supply for the growth and viability of a potentially large subset of malignant tumors. Read More

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November 2018
5 Reads

A 'Fingerprint' of locomotor maturation: Motor development descriptors, reference development bands and data-set.

Gait Posture 2018 Nov 29;68:232-237. Epub 2018 Nov 29.

Department of Electrical, Electronic and Information Engineering "Guglielmo Marconi", University of Bologna, Via del Risorgimento 2, 40136 Bologna, Italy.

Background: When aiming at studying and monitoring locomotor development in childhood, innovative indexes for the characterization of motor control performance and wearable technologies have highlighted the potential of significant advances. In particular, quantitative assessment of motor performance during natural walking (NW) and tandem walking (TW) has been proposed to highlight manifestations of motor automaticity and complexity, respectively.

Research Question: This work aims at providing a quantitative overview of metrics characterizing locomotor maturation in a typically developing population, by analysing NW and TW. Read More

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November 2018

Water drop-surface interactions as the basis for the design of anti-fogging surfaces: Theory, practice, and applications trends.

Adv Colloid Interface Sci 2018 Nov 24;263:68-94. Epub 2018 Nov 24.

Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de Génie des Mines, de la Métallurgie et des Matériaux, Université Laval, 1065 Avenue de la médecine, Québec G1V 0A6, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Québec, Hôpital St-François d'Assise, 10 rue de l'Espinay, Québec G1L 3L5, Canada. Electronic address:

Glass- and polymer-based materials have become essential in the fabrication of a multitude of elements, including eyeglasses, automobile windshields, bathroom mirrors, greenhouses, and food packages, which unfortunately mist up under typical operating conditions. Far from being an innocuous phenomenon, the formation of minute water drops on the surface is detrimental to their optical properties (e.g. Read More

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November 2018

[Morbidity in Prematurity Associated with Fetal Growth Restriction: Experience of a Tertiary Care Center].

Acta Med Port 2018 Nov 30;31(11):648-655. Epub 2018 Nov 30.

Serviço de Neonatologia. Departamento de Pediatria. Hospital Universitário de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants.

Material And Methods: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years. Read More

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November 2018

Global Development of Anticancer Therapies for Rare Cancers, Pediatric Cancers, and Molecular Subtypes of Common Cancers.

J Glob Oncol 2018 Dec(4):1-11

H. Kim Lyerly, Duke University, Durham, NC; Jun Ren, Capital University Medical Center; Zhimin Yang, China Food and Drug Administration, Beijing, People's Republic of China; Gi Hyun Kim, Korea Ministry of Food and Drug Safety, Seoul, South Korea; Sumimasa Nagai, University of Tokyo; Sumimasa Nagai, Tomohiro Yamaguchi, and Ken Hatogai, Pharmaceuticals and Medical Devices Agency; Hiroshi Katayama, National Cancer Center Hospital, Tokyo, Japan; Silvy Da Rocha Dias, European Medicines Agency, London, United Kingdom; Daniel McManus and Kathy Soltys, Health Canada, Ottawa, Ontario, Canada; Olufumilayo Olopade, University of Chicago, Chicago, IL; Nancy Goodman, Kids V Cancer, Washington, DC; Greg Reaman, US Food and Drug Administration; Thomas Gross, US National Cancer Institute, Bethesda, MD, and Renzo Canetta, Independent Consultant.

Advances in genetic sequencing and other diagnostic technologies have enabled the use of precision medicine in clinical cancer care, as well as the development of novel therapies that are targeted to specific molecular drivers of cancer. Developing these new agents and making them accessible to patients requires global clinical studies and regulatory review and approval by different national regulatory agencies. Whereas these global trials present challenges for drug developers who conduct them and regulatory agencies who oversee them, they also raise practical issues about patients with low-frequency cancers who need these therapies. Read More

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December 2018
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An RK/ST C-terminal Motif is Required for Targeting of OEP7.2 and a Subset of Other Arabidopsis Tail-Anchored Proteins to the Plastid Outer Envelope Membrane.

Plant Cell Physiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.

Tail-anchored (TA) proteins are a unique class of integral membrane proteins that possess a single C-terminal transmembrane domain and target post-translationally to the specific organelles at which they function. While significant advances have been made in recent years in elucidating the mechanisms and molecular targeting signals involved in the proper sorting of TA proteins, particularly to the endoplasmic reticulum and mitochondria, relatively little is known about the targeting of TA proteins to the plastid outer envelope. Here we show that several known or predicted plastid TA outer envelope proteins (OEPs) in Arabidopsis possess a C-terminal RK/ST sequence motif that serves as a conserved element of their plastid targeting signal. Read More

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December 2018
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Advances in Genomic Hepatocellular Carcinoma Research.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Graduate School of Integrative Sciences and Engineering, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 117456, Singapore.

Background: Hepatocellular carcinoma (HCC) is the cancer with the second highest mortality in the world due to its late presentation and limited treatment options. As such, there is an urgent need to identify novel biomarkers for early diagnosis and develop novel therapies. The availability of Next Generation Sequencing (NGS) data from tumors of liver cancer patients has provided us with invaluable resources to better understand HCC through the integration of data from different sources to facilitate the identification of promising biomarkers or therapeutic targets. Read More

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December 2018

Inflammatory and Infectious Syndromes Associated with Cancer Immunotherapies.

Clin Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Harvard Medical School, Boston, MA, USA.

Immunotherapy using antibodies to immune checkpoint molecules or targeted chimeric antigen receptor-modified T (CAR-T) cells represent dramatic advances in cancer treatment. These therapies mediate immune-related adverse events (irAEs) which may mimic or amplify infectious presentations. Checkpoint inhibitor therapy may be associated with diverse irAEs including mild skin, endocrine and autoimmune manifestations or severe inflammatory processes including colitis, pneumonitis, myocarditis, and shock. Read More

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December 2018
2 Reads

Computer vision-based phenotyping for improvement of plant productivity: A machine learning perspective.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Department of Information Engineering and Computer Science, University of Trento, Via Sommarive 9, 38123 Trento, Italy.

Employing computer vision to extract useful information from images and videos is becoming a key technique for identifying phenotypic changes in plants. In this report, we review the emerging aspects of computer vision for automated plant phenotyping. Recent advances in image analysis empowered by machine learning-based techniques, including convolutional neural network-based modeling, have expanded their application to assist high-throughput plant phenotyping. Read More

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December 2018

The Yale Center for Biomedical Innovation and Technology (CBIT): One Model to Accelerate Impact From Academic Health Care Innovation.

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

A.L. Siefert is engineering director, Yale Center for Biomedical Innovation and Technology (CBIT), and biomedical engineering lecturer, Yale University, New Haven, Connecticut. M.S. Cartiera is investment and innovation director, Yale CBIT and Center for Health Innovation, Yale New Haven Health System, New Haven, Connecticut. A.N. Khalid is clinical director, Yale CBIT, New Haven, Connecticut; and clinical instructor, Harvard Medical School, Boston, Massachusetts. M.C. Nantel is program coordinator, Yale CBIT, New Haven, Connecticut. C.R. Loose is co-executive director, Yale CBIT, New Haven, Connecticut; and chief scientific officer, Frequency Therapeutics, Cambridge, Massachusetts. P.G. Schulam is co-founder, Yale CBIT, chair of Urology, Yale School of Medicine, and faculty director, Tsai Center for Innovative Thinking, Yale University, New Haven, Connecticut. W.M. Saltzman is co-founder, Yale CBIT, and Goizueta Foundation Professor of biomedical and chemical engineering, Yale University, New Haven, Connecticut. M.K. Dempsey is co-executive director, Yale CBIT, New Haven, Connecticut; and entrepreneur-in-residence, Consortia for Improving Medicine with Innovation & Technology (CIMIT), Boston, Massachusetts.

The process of translating academic biomedical advances into clinical care improvements is difficult, risky, expensive, and poorly understood. Notably, many clinicians who identify health care problems do not have the time or expertise to solve the problems, and many academic researchers are unaware of important gaps in clinical care to which their expertise may apply.Recognizing an opportunity to connect people who can identify health care problems with those who can solve them, the Yale Center for Biomedical Innovation and Technology (CBIT) was established in 2014 to educate and enhance the impact of health care innovators. Read More

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December 2018
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Diagnostic accuracy of computed tomography coronary angiography utilising recent advances in technology in patients with high heart rates: a systematic review protocol.

JBI Database System Rev Implement Rep 2018 Dec 4. Epub 2018 Dec 4.

Joanna Briggs Institute, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia.

Review Question: The primary question to be considered in this review is: what is the diagnostic accuracy of a computed tomography coronary angiography scan utilising recent advances in technology compared to invasive coronary angiography for adult patients with high heart rates in the diagnosis of coronary artery disease?A secondary question will also be considered: what is the diagnostic accuracy of a computed tomography coronary angiography scan utilising individual technologies compared with invasive coronary angiography for adult patients with high heart rates in the diagnosis of coronary artery disease? Read More

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December 2018

An embodied neurocomputational framework for organically integrating biopsychosocial processes: An application to the role of social support in health and disease.

Psychosom Med 2018 Dec 5. Epub 2018 Dec 5.

University of Arizona, Departments of Psychiatry, 1501 N. Campbell Ave, Tucson, AZ 85724-5002, United States.

Objective: Two distinct perspectives - typically referred to as the biopsychosocial and biomedical models - currently guide clinical practice. While the role of psychosocial factors in contributing to physical and mental health outcomes is widely recognized, the biomedical model remains dominant. This is due in part to 1) the largely non-mechanistic focus of biopsychosocial research, and 2) the lack of specificity it currently offers in guiding clinicians to focus on social, psychological, and/or biological factors in individual cases. Read More

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December 2018
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Biomarkers for chronic obstructive pulmonary disease diagnosis and progression: insights, disappointments and promise.

Authors:
David M Mannino

Curr Opin Pulm Med 2018 Dec 4. Epub 2018 Dec 4.

Medical Affairs, GlaxoSmithKline, Philadelphia, Pennsylvania.

Purpose Of Review: This article reviews the status of biomarkers useful in the diagnosis and progression of chronic obstructive pulmonary disease (COPD). Biomarkers have been the focus of a great deal of COPD-related research in recent years, although useful markers in these specific arenas remain elusive.

Recent Findings: No biomarker other than lung function has been shown to be useful, to date, for the diagnosis of COPD. Read More

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December 2018

Auxiliary subunits keep AMPA receptors compact during activation and desensitization.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Institute of Biology, Cellular Biophysics, Humboldt Universität zu Berlin, Berlin, Germany.

Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers. Technical advances in cryo-electron microscopy brought a slew of full-length structures of AMPA receptors, on their own and in combination with auxiliary subunits. These structures indicate that dimers might undergo substantial lateral motions during gating, opening up the extracellular layer along the central 2-fold symmetry axis. Read More

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December 2018
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Social behaviour and making attachments: a report from the fifth 'Young Microbiologists Symposium on Microbe Signalling, Organisation and Pathogenesis'.

Microbiology 2018 Dec 6. Epub 2018 Dec 6.

1​Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.

The fifth Young Microbiologists Symposium was held in Queen's University Belfast, Northern Ireland, in late August 2018. The symposium, focused on 'Microbe signalling, organization and pathogenesis', attracted 121 microbiologists from 15 countries. The meeting allowed junior scientists to present their work to a broad audience, and was supported by the European Molecular Biology Organization, the Federation of European Microbiological Societies, the Society of Applied Microbiology, the Biochemical Society and the Microbiology Society. Read More

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December 2018
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Mesoporous silica nanoparticles as a prospective and promising approach for drug delivery and biomedical applications.

Curr Cancer Drug Targets 2018 Dec 5. Epub 2018 Dec 5.

Institute of Materia Medica, School of Pharmacy, Henan University, Jinming Road, Kaifeng, 475004. China.

Background: With the development of nanotechnology, nanocarrier has widely applied in such fields as drug delivery, diagnostic and medical imaging and engineering in recent years. Among all of the available nanocarrier, mesoporous silica nanoparticles (MSNs) have become a hot issue because of their unique properties, such as large surface area and voidage, tunable drug loading capacity and release kinetics, good biosafety and easily modified surface.

Objectives: We described the most recent progress in silica-assisted drug delivery and biomedical applications according to different types of Cargo in order to allow researchers to quickly learn about of the advance in this field. Read More

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December 2018

3D printing Technology in drug delivery: Recent progress and Application.

Curr Pharm Des 2018 Dec 6. Epub 2018 Dec 6.

College of Pharmacy and Dentistry, Buraydah Private Colleges, Buraydah. Saudi Arabia.

Background: 3D printing technology is a new chapter in pharmaceutical manufacturing and has gained vast interest in the recent past as it offers significant advantages over traditional pharmaceutical processes. Advances in technologies can lead to design of suitable 3D printing device capable of producing formulations with intended drug release.

Methods: This review summarizes the applications of 3D printing technology in various drug delivery systems. Read More

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December 2018

Advances in Management of Neonatal Abstinence Syndrome: What’s the score?

Ir Med J 2018 08 13;111(7):785. Epub 2018 Aug 13.

Department of Paediatrics, Midland Regional Hospital, Mullingar, Co. Westmeath

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Critical review of emergency department management of chemotherapy complications in cancer patients.

Eur J Cancer Care (Engl) 2018 Dec 5:e12974. Epub 2018 Dec 5.

Melbourne School of Health Sciences, The University of Melbourne, Carlton, Victoria, Australia.

Introduction: Recent worldwide advances in cancer therapies have resulted in an increased number of people receiving chemotherapy in ambulatory care settings. In Spain, emergency departments are the single point of entry to acute inpatient services and they play a pivotal role in the management of chemotherapy complications. Little research exists in patterns of emergency department utilisation by oncology patients with chemotherapy-related complications. Read More

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December 2018

A revolutionary tool: CRISPR technology plays an important role in construction of intelligentized gene circuits.

Cell Prolif 2018 Dec 5:e12552. Epub 2018 Dec 5.

Department of Urology, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.

With the development of synthetic biology, synthetic gene circuits have shown great applied potential in medicine, biology, and as commodity chemicals. An ultimate challenge in the construction of gene circuits is the lack of effective, programmable, secure and sequence-specific gene editing tools. The clustered regularly interspaced short palindromic repeat (CRISPR) system, a CRISPR-associated RNA-guided endonuclease Cas9 (CRISPR-associated protein 9)-targeted genome editing tool, has recently been applied in engineering gene circuits for its unique properties-operability, high efficiency and programmability. Read More

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December 2018
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Therapeutic strategies for skin regeneration based on biomedical substitutes.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, E-18071, Spain.

Regenerative medicine and tissue engineering (TE) have experienced significant advances in the development of in vitro engineered skin substitutes, either for replacement of lost tissue in skin injuries or for the generation of in vitro human skin models to research. However, currently available skin substitutes present different limitations such as expensive costs, abnormal skin microstructure and engraftment failure. Given these limitations, new technologies, based on advanced therapies and regenerative medicine, have been applied to develop skin substitutes with several pharmaceutical applications that include injectable cell suspensions, cell-spray devices, sheets or 3D-scaffolds for skin tissue regeneration and others. Read More

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December 2018
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VIII. CONCLUSION: CO-CONSTRUCTING A SECURE BASE PARTNERSHIP: MOTHER-CHILD INTERACTIONS, COMMUNICATION, AND SCRIPT REPRESENTATIONS.

Monogr Soc Res Child Dev 2018 Dec;83(4):121-134

Using the secure base construct, the evidence presented indicates that interactional experience continues to be a central factor in the organization of mother-child attachment relationships. The parent-child codetermination process that establishes their relationship in infancy expands during the preschool years. Furthermore, with the increasingly relevant role of language, parent-child verbal communication during this time plays an important part in structuring children's attachment behavior and knowledge. Read More

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December 2018

Human paleoneurology: shaping cortical evolution in fossil hominids.

Authors:
Emiliano Bruner

J Comp Neurol 2018 Dec 5. Epub 2018 Dec 5.

Centro Nacional de Investigación sobre la Evolución Humana, Spain.

Evolutionary neuroanatomy must integrate two different sources of information, namely from fossil and from living species. Fossils supply information concerning the process of evolution, while living species supply information on the product of evolution. Unfortunately, the fossil record is partial and fragmented, and often cannot support validations for specific evolutionary hypotheses. Read More

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December 2018
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Effect of Silk Fibroin on Neuroregeneration After Traumatic Brain Injury.

Neurochem Res 2018 Dec 5. Epub 2018 Dec 5.

A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.

Traumatic brain injury is one of the leading causes of disability among the working-age population worldwide. Despite attempts to develop neuroprotective therapeutic approaches, including pharmacological or cellular technologies, significant advances in brain regeneration have not yet been achieved. Development of silk fibroin-based biomaterials represents a new frontier in neuroregenerative therapies after brain injury. Read More

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December 2018
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High-performance stretchable conductive nanocomposites: materials, processes, and device applications.

Chem Soc Rev 2018 Dec 6. Epub 2018 Dec 6.

Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea and Institute of Chemical Processing (ICP), Seoul National University, Seoul 08826, Republic of Korea.

Highly conductive and intrinsically stretchable electrodes are vital components of soft electronics such as stretchable transistors and circuits, sensors and actuators, light-emitting diode arrays, and energy harvesting devices. Many kinds of conducting nanomaterials with outstanding electrical and mechanical properties have been integrated with elastomers to produce stretchable conductive nanocomposites. Understanding the characteristics of these nanocomposites and assessing the feasibility of their fabrication are therefore critical for the development of high-performance stretchable conductors and electronic devices. Read More

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December 2018
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Uncertainty quantification of a DNA origami mechanism using a coarse-grained model and kinematic variance analysis.

Nanoscale 2018 Dec 6. Epub 2018 Dec 6.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio 43210, USA.

Significant advances have been made towards the design, fabrication, and actuation of dynamic DNA nanorobots including the development of DNA origami mechanisms. These DNA origami mechanisms integrate relatively stiff links made of bundles of double-stranded DNA and relatively flexible joints made of single-stranded DNA to mimic the design of macroscopic machines and robots. Despite reproducing the complex configurations of macroscopic machines, these DNA origami mechanisms exhibit significant deviations from their intended motion behavior since nanoscale mechanisms are subject to significant thermal fluctuations that lead to variations in the geometry of the underlying DNA origami components. Read More

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December 2018
2 Reads

Stroke: The past, present and future.

Brain Neurosci Adv 2018 ;2:2398212818810689

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Since the inception of the British Neuroscience Association, there have been major advances in our knowledge of the mechanistic basis for stroke-induced brain damage. Identification of the ischaemic cascade led to the development of hundreds of new drugs, many showing efficacy in preclinical (animal-based) studies. None of these drugs has yet translated to a successful stroke treatment, current therapy being limited to thrombolysis/thrombectomy. Read More

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January 2018

Recent advances in the management of nasopharyngeal carcinoma.

F1000Res 2018 21;7. Epub 2018 Nov 21.

Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Over the last few years, certain areas in the management nasopharyngeal carcinoma (NPC) that have an impact on the care of these patients have evolved, particularly with regard to liquid biopsies, minimally invasive surgery, and advances in chemotherapy and immunotherapy. Beyond its proven role in the diagnostics, surveillance, and treatment of NPC, liquid biopsy with plasma Epstein-Barr virus DNA in the screening of high-risk populations for NPC is strongly supported by recent evidence. Surgery of the nasopharynx is reserved for locally recurrent NPC, and in recent years there have been great strides in minimally invasive techniques with survival rates similar to those of open techniques in treating NPC. Read More

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November 2018
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RNA interactomics: recent advances and remaining challenges.

F1000Res 2018 20;7. Epub 2018 Nov 20.

Institute of Biochemical Engineering, Computational Biology Group, University of Stuttgart, Stuttgart, 70569, Germany.

Tight regulation of cellular processes is key to the development of complex organisms but also vital for simpler ones. During evolution, different regulatory systems have emerged, among them RNA-based regulation that is carried out mainly by intramolecular and intermolecular RNA-RNA interactions. However, methods for the transcriptome-wide detection of these interactions were long unavailable. Read More

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November 2018

The impact of artificial light at night on nocturnal insects: A review and synthesis.

Ecol Evol 2018 Nov 23;8(22):11337-11358. Epub 2018 Oct 23.

Department of Biology Tufts University Medford Massachusetts.

In recent decades, advances in lighting technology have precipitated exponential increases in night sky brightness worldwide, raising concerns in the scientific community about the impact of artificial light at night (ALAN) on crepuscular and nocturnal biodiversity. Long-term records show that insect abundance has declined significantly over this time, with worrying implications for terrestrial ecosystems. The majority of investigations into the vulnerability of nocturnal insects to artificial light have focused on the flight-to-light behavior exhibited by select insect families. Read More

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November 2018

Soil organic carbon dynamics matching ecological equilibrium theory.

Ecol Evol 2018 Nov 18;8(22):11169-11178. Epub 2018 Oct 18.

School of Integrative Plant Science Cornell University Ithaca New York.

The persistence of soil organic carbon (SOC) has traditionally been explained as a combination of recalcitrance properties and stabilization processes, which lead to the formation of complex organic compounds. However, recent conceptual advances and experimental evidence challenge this view. Here, we test these conceptual advances using a dynamic equilibrium theory of SOC founded on classic ecological theory. Read More

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November 2018

Current Strategies of Polyploid Plant Genome Sequence Assembly.

Front Plant Sci 2018 21;9:1660. Epub 2018 Nov 21.

Department of Plant Science, McGill University, Montreal, QC, Canada.

Polyploidy or duplication of an entire genome occurs in the majority of angiosperms. The understanding of polyploid genomes is important for the improvement of those crops, which humans rely on for sustenance and basic nutrition. As climate change continues to pose a potential threat to agricultural production, there will increasingly be a demand for plant cultivars that can resist biotic and abiotic stresses and also provide needed and improved nutrition. Read More

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November 2018

Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson's Disease.

Front Hum Neurosci 2018 21;12:462. Epub 2018 Nov 21.

Department of Psychiatry, Faculty of Medicine, Masaryk University and University Hospital Brno, Brno, Czechia.

The phenomenon of impulsivity in Parkinson's disease appears as an arduous side effect of dopaminergic therapy with potentially detrimental consequences for the life of the patients. Although conceptualized as a result of non-physiologic chronic dopaminergic stimulation, recent advances speculate on combined disruption of other networks as well. In the search for neuroanatomical correlates of this multifaceted disturbance, this study employs two distinct, well-defined tasks of close association to motor inhibition and decision-making impulsivity, Go/No Go and Delay discounting. Read More

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November 2018
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Predictors of stent thrombosis and their implications for clinical practice.

Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Kardiologie I, Zentrum für Kardiologie, University Medical Center Mainz and DZHK Standort Rhein-Main, Mainz, Germany.

Stent thrombosis (ST) is a rare but severe complication of coronary procedures with high mortality, high relapse rate and a very complex pathophysiology. An individual's susceptibility to ST is multifactorial and results from interactions between clinical factors, endothelial biology, hypersensitivity and/or inflammatory reactions, blood rheology, platelet reactivity, clotting factors, physical and mechanical properties of the stent and from the effects of these different factors on the fluid dynamics of blood flow. Since the introduction of stents 32 years ago, continuous improvements in our understanding of the pathophysiology of ST have triggered important advances, including new therapies, new technologies and an increased awareness of the implications of implantation techniques. Read More

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December 2018

LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA.

Cell Death Dis 2018 Dec 5;9(12):1167. Epub 2018 Dec 5.

Department of Radiation Oncology, Zhejiang Provincial People' s Hospital, People' s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P.R. China.

Abstact: Conventional therapies and novel molecular targeted therapies against breast cancer have gained great advances over the past two decades. However, poor prognosis and low survival rate are far from expectation for improvement, particularly in patients with triple negative breast cancer (TNBC). Here, we found that lncRNA DANCR was significantly overregulated in TNBC tissues and cell lines compared with normal breast tissues or other type of breast cancer. Read More

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December 2018

Autonomic dysfunction in programmed hypertension.

J Hum Hypertens 2018 Dec 5. Epub 2018 Dec 5.

School of Medical Sciences & Bosch Institute, The University of Sydney, Sydney, Australia.

Hypertension is an important modifiable risk factor for cardiovascular diseases. Its high prevalence, combined with the significant morbidity and mortality associated with secondary complications, make it a major public health concern. Despite decades of research, over 95% of all cases of hypertension remain of unknown etiology, necessitating that treatments target the established symptoms and not the cause. Read More

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December 2018
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Loss of the candidate tumor suppressor ZEB1 (TCF8, ZFHX1A) in Sézary syndrome.

Cell Death Dis 2018 Dec 5;9(12):1178. Epub 2018 Dec 5.

Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.

Cutaneous T-cell lymphoma is a group of incurable extranodal non-Hodgkin lymphomas that develop from the skin-homing CD4 T cell. Mycosis fungoides and Sézary syndrome are the most common histological subtypes. Although next-generation sequencing data provided significant advances in the comprehension of the genetic basis of this lymphoma, there is not uniform consensus on the identity and prevalence of putative driver genes for this heterogeneous group of tumors. Read More

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December 2018

Clinical Microbiology Is Growing Up: The Total Laboratory Automation Revolution.

Clin Chem 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO;

Background: Historically, culture-based microbiology laboratory testing has relied on manual methods, and automated methods (such as those that have revolutionized clinical chemistry and hematology over the past several decades) were largely absent from the clinical microbiology laboratory. However, an increased demand for microbiology testing and standardization of sample-collection devices for microbiology culture, as well as a dwindling supply of microbiology technologists, has driven the adoption of automated methods for culture-based laboratory testing in clinical microbiology.

Content: We describe systems currently enabling total laboratory automation (TLA) for culture-based microbiology testing. Read More

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December 2018

Using mixed effects logistic regression models for complex survey data on malaria rapid diagnostic test results.

Malar J 2018 Dec 5;17(1):453. Epub 2018 Dec 5.

School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.

Background: The effect of malaria in Nigeria is still worrisome and has remained a leading public health issue in the country. In 2016, Nigeria was the highest malaria burden country among the 15 countries in sub-Saharan Africa that accounted for the 80% global malaria cases. The purpose of this study is to utilize appropriate statistical models in identifying socio-economic, demographic and geographic risk factors that have influenced malaria transmission in Nigeria, based on malaria rapid diagnostic test survey results. Read More

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December 2018
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Alpha shapes: determining 3D shape complexity across morphologically diverse structures.

BMC Evol Biol 2018 Dec 5;18(1):184. Epub 2018 Dec 5.

School of Science and the Environment, Manchester Metropolitan University, Manchester, M1 5GD, UK.

Background: Following recent advances in bioimaging, high-resolution 3D models of biological structures are now generated rapidly and at low-cost. To use this data to address evolutionary and ecological questions, an array of tools has been developed to conduct shape analysis and quantify topographic complexity. Here we focus particularly on shape techniques applied to irregular-shaped objects lacking clear homologous landmarks, and propose a new 'alpha-shapes' method for quantifying 3D shape complexity. Read More

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December 2018

The Biological Significance and Regulatory Mechanism of c-Myc Binding Protein 1 (MBP-1).

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Beijing Key Laboratory of Gene Resource and Molecular Development/College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Alternatively translated from the gene and expressed in an array of vertebrate and plant tissues, c-Myc binding protein 1 (MBP-1) participates in the regulation of growth in organisms, their development and their environmental responses. As a transcriptional repressor of multiple proto-oncogenes, vertebrate MBP-1 interacts with other cellular factors to attenuate the proliferation and metastasis of lung, breast, esophageal, gastric, bone, prostrate, colorectal, and cervical cancer cells. Due to its tumor-suppressive property, MBP-1 and its downstream targets have been investigated as potential prognostic markers and therapeutic targets for various cancers. Read More

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December 2018
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A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

International Research Organization for Advanced Science and Technology (IROAST), Kumamoto University, Kumamoto 860-8555, Japan.

Designing new drug delivery systems (DDSs) for safer cancer therapy during pre-clinical and clinical applications still constitutes a considerable challenge, despite advances made in related fields. Lipid-based drug delivery systems (LBDDSs) have emerged as biocompatible candidates that overcome many biological obstacles. In particular, a combination of the merits of lipid carriers and functional polymers has maximized drug delivery efficiency. Read More

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December 2018

Patterns of arboreal and terrestrial space use by non-volant small mammals in an Araucaria forest of southern Brazil.

An Acad Bras Cienc 2014 Jun;86(2):807-819

Laboratório de Ecologia de Mamíferos, Universidade do Vale do Rio dos Sinos/UNISINOS, São Leopoldo, RS, Brasil.

Despite the advances in the techniques for researching arboreal small mammals, detailed ecological data, such as habitat use patterns, are practically nonexistent for many species. Using 150 live-traps installed on the ground, understory (1.0-5. Read More

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Role of Image-Enhanced Endoscopy in Pancreatobiliary Diseases.

Clin Endosc 2018 Nov 30;51(6):541-546. Epub 2018 Nov 30.

Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.

Recent advances in cholangiopancreatoscopy technology permit image-enhanced endoscopy (IEE) for pancreatobiliary diseases. There are limitations in endoscopy performance and in the study of the clinical role of IEE in bile duct or pancreatic duct diseases. However, currently available IEEs during cholangiopancreatoscopy including traditional dye-aided chromoendoscopy, autofluorescence imaging, narrow-band imaging, and i-Scan have been evaluated and reported previously. Read More

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November 2018
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[Sjögren's Syndrome: Early diagnosis and effective treatment].

Authors:
Torsten Witte

Dtsch Med Wochenschr 2018 Dec 3;143(24):1778-1782. Epub 2018 Dec 3.

Klinik für Immunologie und Rheumatologie der Medizinischen Hochschule Hannover.

Primary Sjögren's syndrome (pSS) is an autoimmune disease affecting the salivary and lachrymal glands. The patients complain of symptoms of dry eyes and dry mouth, but up to 50 % may additionally develop extraglandular manifestations such as arthritis, vasculitis, polyneuropathy, pulmonary fibrosis or interstitial nephritis. Most therapeutic studies on the glandular manifestations of pSS failed to meet their primary endpoints, possibly since many of the patients had already advanced and irreversible disease. Read More

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December 2018
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Treatment of Osteoporosis, with a Focus on 2 Monoclonal Antibodies.

Med Sci Monit 2018 Dec 3;24:8758-8766. Epub 2018 Dec 3.

Department of Laser Medicine, Chinese People's Liberation Army General Hospital, Beijing, China (mainland).

Osteoporosis is a common skeletal disease characterized by bone loss and subsequent increased risk of fragility fractures. Recent advances in our mechanistic understanding of molecular communications among osteoblasts, osteoclasts, and osteocytes give insight into the important roles of the canonical Wnt/β-catenin pathway and the RANK/RANKL/OPG pathway in the process of bone remodeling. Due to the translation of the canonical Wnt/β-catenin pathway and the RANK/RANKL/OPG pathway in the regulation of osteoblasts and osteoclasts, new targets have been studied in recent years, such as sclerostin and receptor activator of NF-κB ligand (RANKL). Read More

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December 2018
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Integrated adsorption and photocatalytic degradation of volatile organic compounds (VOCs) using carbon-based nanocomposites: A critical review.

Chemosphere 2018 Nov 27;218:845-859. Epub 2018 Nov 27.

School of the Environment, Nanjing University, Nanjing 210093, PR China; Jiangsu Key Laboratory of Vehicle Emissions Control, Center of Modern Analysis, Nanjing University, Nanjing 210093, PR China. Electronic address:

Volatile organic compounds (VOCs) are harmful for human and surrounding ecosystem, and a great number of VOC abatement technologies have been developed during the past few decades. However, the single method has some problems such as high energy consumption, unfriendly environment, and low removal efficiency. Recently, the integration of adsorption and photocatalytic degradation of VOCs is considered as a promising one. Read More

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November 2018