800 results match your criteria Advances in Anatomic Pathology[Journal]


Pathogenesis of Testicular Germ Cell Neoplasia: A Conceptual Approach.

Adv Anat Pathol 2019 Apr 3. Epub 2019 Apr 3.

Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA.

Testicular germ cell tumors are a diverse group of neoplasms, consisting of the prepubertal type 1 tumors, pure teratoma, and pure yolk sac tumor, the type 2 tumors, which are biologically malignant, preceded by germ cell neoplasia in situ, and harbor chromosome 12p abnormalities, and the type 3 tumor, spermatocytic tumor, which features chromosome 9p amplification. These arise in distinct clinical settings, and harbor distinct genetic abnormalities, immunohistochemical properties, and morphologic features. Here we have attempted to unify embryology, morphology, immunohistochemistry, and genetics in order to distill this fascinating group of neoplasms into what we hope is a useful framework for understanding their classification. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000233DOI Listing
April 2019
2 Reads

Determination of Mismatch Repair Status in Human Cancer and Its Clinical Significance: Does One Size Fit All?

Adv Anat Pathol 2019 Mar 29. Epub 2019 Mar 29.

Division of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

The clinical management of cancers has progressed rapidly into the immunopathology era, with the unprecedented histology-agnostic approval of pembrolizumab in mismatch repair (MMR) deficient tumors. Despite the significant recent achievements in the treatment of these patients, however, the identification of clinically relevant subclasses of cancers based on the MMR status remains a major challenge. Many investigations have assessed the role of different diagnostic tools, including immunohistochemistry, microsatellite instability, and tumor mutational burden in both prognostic and therapeutic settings, with heterogenous results. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000234DOI Listing

Non-Neoplastic and Benign Tumoral Lesions of the Thymic Gland: A Review and Update.

Adv Anat Pathol 2019 Mar 29. Epub 2019 Mar 29.

Department of Pathology, MD Anderson Cancer Center, Houston, TX.

The thymus is a dynamic organ that undergoes changes throughout life and can demonstrate a myriad of pathologic alterations. A number of benign entities of the thymus prove to be diagnostic dilemmas owing to their resemblance and association with true thymic tumors. These are usually discovered incidentally on routine imaging and most patients are either asymptomatic or present with signs and symptoms of compression of adjacent organs. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000231DOI Listing

Review of Drug-induced Injury in Mucosal Biopsies From the Tubular Gastrointestinal Tract.

Adv Anat Pathol 2019 May;26(3):151-170

Department of Pathology, University of Virginia, Charlottesville, VA.

The use of prescription and over-the-counter medications is on the rise in the US population, especially among those aged 65 and over, with over 46% of the population taking at least 1 prescription medication. Given the frequency of medication use, and that the majority of these medications are taken orally, it has become increasingly relevant for pathologist examining endoscopically obtained gastrointestinal tract mucosal biopsies to consider and recognize patterns of mucosal injury associated with various drugs. Reports on injuries associated with certain classes of drugs can be scattered among different sources, making a comprehensive view of various injury patterns and the drugs known to cause them difficult to obtain. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000230DOI Listing

The Implementation of an Introductory Surgical Pathology Didactic Series to Transition First Year Residents and Facilitate Upper Level Resident Teaching.

Adv Anat Pathol 2019 May;26(3):210-214

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

The increasing complexity of the practice of pathology and health care in general requires that pathology residents acquire a vast number of skills during their training. This has been reflected by the broad range of skills addressed in the Accreditation Council for Graduate Medical Education (ACGME) milestones. In order to address some of these milestones, our residency program instituted an introductory didactic series in surgical pathology that focused on 2 objectives. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000229DOI Listing
May 2019
1 Read

Epithelioid Vascular Tumors: A Review.

Adv Anat Pathol 2019 May;26(3):186-197

Department of Pathology, Cleveland Clinic, Cleveland, OH.

Vascular tumors are a diagnostically challenging area. This is particularly true in the case of epithelioid vascular tumors. Not only is the distinction between different epithelioid vascular tumors challenging, but also the differential diagnosis may be substantially expanded by the inclusion of melanoma, carcinomas, and other epithelioid soft tissue tumors. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000228DOI Listing
May 2019
9 Reads

New and Emerging Biomarkers in Endocrine Pathology.

Adv Anat Pathol 2019 May;26(3):198-209

Department of Pathology, Massachusetts General Hospital.

Significant advances in genomics and molecular genetics in recent years have reshaped the practice of endocrine pathology. Pan-genomic studies, including the pioneering ones on papillary thyroid carcinoma, phaeochromocytoma/paraganglioma, and adrenal cortical carcinoma from the Cancer Genome Atlas (TCGA) project, provided a comprehensive integrated genomic analysis of endocrine tumors into distinct molecularly defined subtypes. Better understanding of the molecular landscape and more accurate definition of biological behavior has been accordingly achieved. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000227DOI Listing
May 2019
4 Reads

Iatrogenic Disease of the Genitourinary Tract.

Authors:
Helen P Cathro

Adv Anat Pathol 2019 May;26(3):171-185

Department of Pathology and Laboratory Medicine, University of Virginia, Charlottesville, VA.

Iatrogenic disease is defined as illness caused by diagnostic procedures or treatment given by health care professionals. More recently described treatment complications involving the genitourinary tract include newly recognized variants of renal carcinoma in the setting of dialysis/end-stage renal disease, treatment effect in genitourinary carcinomas, and medical renal disease caused by drug therapies, including immunotherapy. The objective of this review is to cover iatrogenic inflammatory diseases, pseudotumors and tumors of the kidney, bladder, prostate, testis and paratestis of most interest to surgical pathologists. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000226DOI Listing
May 2019
1 Read

Advances in Diagnostic Immunohistochemistry for Primary Tumors of the Central Nervous System.

Authors:
David M Meredith

Adv Anat Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

As genomic characterization becomes increasingly necessary for accurate diagnosis of tumors of the central nervous system, identification of rapidly assessible biomarkers is equally important to avoid excessive cost and delay in initiation of therapy. This article reviews novel immunohistochemical markers that may be used to determine mutation status, activation of signaling pathways, druggable targets, and cell lineage in many diverse tumor types. In particular, recently added entities to the 2016 WHO classification of central nervous system tumors will be addressed, including IDH-mutant gliomas, diffuse midline glioma, epithelioid glioblastoma, angiocentric glioma, RELA-rearranged ependymoma, embryonal tumors (medulloblastoma, atypical teratoid/rhabdoid tumor, pineoblastoma, embryonal tumor with multilayered rosettes, and other genetically defined high-grade neuroepithelial tumors), and meningiomas associated with germline alterations. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000225DOI Listing
February 2019
2 Reads

Update on Molecular Testing for Cytologically Indeterminate Thyroid Nodules.

Adv Anat Pathol 2019 Mar;26(2):114-123

Cedars-Sinai Medical Center, Los Angeles, CA.

Fine needle aspiration biopsy (FNAB) and ultrasonography are the most common modalities for the diagnosis and follow up of thyroid nodules. FNAB is able to distinguish benign from malignant nodules with high sensitivity and specificity; however, 20% to 30% of nodules are diagnosed as indeterminate with a risk of malignancy varying from 10% to 75% based on the 2017 revision of the Bethesda System for Reporting Thyroid Cytopathology. Molecular tests are being increasingly used to triage this group of nodules. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000211DOI Listing
March 2019
1 Read

One Actor, Many Roles: Histopathologies Associated With APOL1 Genetic Variants.

Adv Anat Pathol 2019 May;26(3):215-219

Kidney Diseases Branch, NIDDK, NIH, Bethesda.

Genetic variants in APOL1, encoding apolipoprotein L1, are major drivers of glomerular disease in peoples of sub-Saharan African descent. APOL1-associated primary glomerular diseases include focal segmental glomerulosclerosis, human immunodeficiency virus-associated nephropathies, and arterionephrosclerosis. Other conditions where APOL1 variants affect outcomes include membranous nephropathy, lupus nephritis, diabetic nephropathy, preeclampsia, and kidney transplant. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458071PMC
May 2019
5 Reads

Fibrosing/Sclerosing Lesions of the Mediastinum: A Review.

Adv Anat Pathol 2019 Jan 2. Epub 2019 Jan 2.

Departments of Pathology.

Fibrosing lesions of the mediastinum represent a small but challenging group of lesions that range in etiology from infectious to idiopathic to neoplastic. The diagnosis of such lesions becomes more challenging in the setting of mediastinoscopic biopsies. In addition, over the years, there has been further accumulation of knowledge of the clinical aspects of these lesions that needs to be incorporated into their evaluation. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000223DOI Listing
January 2019
1 Read

Goblet Cell Carcinoid/Carcinoma: An Update.

Adv Anat Pathol 2019 Mar;26(2):75-83

Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA.

Goblet cell carcinoid (GCC) or goblet cell carcinoma is a unique mixed endocrine-exocrine neoplasm that is almost exclusively seen in the appendix. The hallmark of GCC is the concentric infiltration of the appendiceal wall by small tight clusters, nests or cords of tumor cells that exhibit a goblet cell morphology with a small compressed nucleus and conspicuous intracytoplasmic mucin. The coexistence of high-grade adenocarcinoma with GCC has been increasingly recognized as a common finding, which has been called adenocarcinoma ex GCC or mixed GCC-adenocarcinoma. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000222DOI Listing
March 2019
7 Reads

Salivary Gland Fine Needle Aspiration and Introduction of the Milan Reporting System.

Adv Anat Pathol 2019 Mar;26(2):84-92

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Fine needle aspiration (FNA) is a well-established procedure for the diagnosis and management of salivary gland lesions despite challenges imposed by their diversity, complexity, and cytomorphologic overlap. Until recently, the reporting of salivary gland FNA specimens was inconsistent among different institutions throughout the world, leading to diagnostic confusion among pathologists and clinicians. In 2015, an international group of pathologists initiated the development of an evidence-based tiered classification system for reporting salivary gland FNA specimens designated the "Milan System for Reporting Salivary Gland Cytopathology" (MSRSGC) that culminated with the publication of the MSRSGC Atlas in February 2018. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000224DOI Listing
March 2019
9 Reads

Papillary Renal Cell Carcinoma (PRCC): An Update.

Adv Anat Pathol 2019 Mar;26(2):124-132

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Papillary renal cell carcinoma (PRCC) is the second most common type of renal carcinoma following clear cell renal cell carcinoma. Papillary renal cell carcinoma is usually divided histologically into 2 types namely, type 1 and type 2. This classification, however, is unsatisfactory as many of papillary carcinoma are unclassifiable by the existing criteria. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000220DOI Listing
March 2019
4 Reads

What's New in Dermatopathology: Inflammatory Dermatoses.

Adv Anat Pathol 2019 Jan;26(1):40-55

Departments of Dermatology.

Inflammatory skin diseases encompass a vast array of conditions. The field continues to expand and evolve with resurgence of conditions, through newly recognized medication adverse effects, and via more detailed descriptions of known dermatoses. The importance of clinicopathologic correlation and an up to date knowledge of dermatologic conditions cannot be overstated. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000210DOI Listing
January 2019
5 Reads

Paget's "Seed and Soil" Theory of Cancer Metastasis: An Idea Whose Time has Come.

Adv Anat Pathol 2019 Jan;26(1):69-74

Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology.

The concept that the pattern of metastatic spread of cancer is not random and that cancer cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven Paget published his "seed and soil" hypothesis. He proposed that the spread of tumor cells is governed by interaction and cooperation between the cancer cells (seed) and the host organ (soil). Extensive studies during the last several decades have provided a better understanding of the process of metastatic spread of cancer and several stages such as intravasation, extravasation, tumor latency, and development of micrometastasis and macrometastasis have been defined. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000219DOI Listing
January 2019
38 Reads

Circulating Tumor Cells: Overview and Opportunities in Cytology.

Adv Anat Pathol 2019 Jan;26(1):56-63

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Circulating tumor cells (CTCs) have long been assumed to be the substrate of cancer metastasis. However, only in recent years have we begun to leverage the potential of CTCs found in minimally invasive peripheral blood specimens to improve care for cancer patients. Currently, CTC enumeration is an accepted prognostic indicator for breast, prostate, and colorectal cancer; however, CTC enumeration remains largely a research tool. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000217DOI Listing
January 2019
8 Reads

Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Atypical Thymoma With Rhabdomyomatous Differentiation.

Adv Anat Pathol 2019 Jan;26(1):64-68

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI.

Thymic epithelial neoplasms with foci of rhabdomyomatous differentiation are rare. A case is presented of a primary thymic epithelial neoplasm showing the features of an atypical spindle cell thymoma that contained foci of bland-appearing rhabdomyomatous cells. The histologic and immunohistochemical features of this tumor are discussed along with a review of the literature and the comments from the AMR members to the case. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000218DOI Listing
January 2019
21 Reads

A "Clearer" View of Pancreatic Pathology: A Review of Tissue Clearing and Advanced Microscopy Techniques.

Adv Anat Pathol 2019 Jan;26(1):31-39

Departments of Pathology.

Although pathologic lesions in the pancreas are 3-dimensional (3D) complex structures, we currently use thin 2D hematoxylin and eosin stained slides to study and diagnose pancreatic pathology. Two technologies, tissue clearing and advanced microscopy, have recently converged, and when used together they open the remarkable world of 3D anatomy and pathology to pathologists. Advances in tissue clearing and antibody penetration now make even dense fibrotic tissues amenable to clearing, and light sheet and confocal microscopies allow labeled cells deep within these cleared tissues to be visualized. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000215DOI Listing
January 2019
18 Reads

An Update on the Role of Immunohistochemistry in the Evaluation of Gastrointestinal Tract Disorders.

Adv Anat Pathol 2018 Sep 18. Epub 2018 Sep 18.

Department of Pathology, Cleveland Clinic, Cleveland, OH.

As in other organ systems, immunohistochemistry (IHC) serves as an ancillary diagnostic tool for a wide variety of neoplastic and non-neoplastic disorders, including infections, work-up of inflammatory conditions, and subtyping neoplasms of the gastrointestinal (GI) tract. In addition, IHC is also used to detect a variety of prognostic and predictive molecular biomarkers for carcinomas of the GI tract. The purpose of this review is to highlight the use of IHC in common diagnostic scenarios throughout the tubular GI tract. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000214DOI Listing
September 2018
4 Reads

Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances.

Adv Anat Pathol 2019 Jan;26(1):1-12

DDL Diagnostic Laboratory, Rijswijk, The Netherlands.

Gastric-type endocervical adenocarcinoma (GAS) is a recently described diagnostic entity originally characterized as a tumor with (1) voluminous cytoplasm that is (2) clear or pale eosinophilic, and (3) cells showing distinct cell borders. Since the initial tumor description there has been accumulating experience that the neoplasm, in addition to classic features, may show a wide spectrum of morphologic appearances. This paper describes and illustrates cases of GAS with focal or diffuse findings that include: densely eosinophilic cytoplasm, foamy cytoplasm, goblet cells, glands with elongated, stratified nuclei, glands with small cuboidal cells, glands with flattened cells, papillary growth, single cell infiltration and infiltration with microcystic elongated and fragmented pattern. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000216DOI Listing
January 2019
5 Reads

Anaplastic Kaposi's Sarcoma of the Adrenal in an HIV-negative Patient With Literature Review.

Adv Anat Pathol 2019 Mar;26(2):133-149

Department of Pathology, The Barzilai Medical Center, Ashkelon, Israel.

Kaposi's sarcoma (KS) is a peculiar tumor of viral etiology, with the HHV8 rhadinovirus playing a fundamental role in its development. Several epidemiological categories of KS have been identified, of which the sporadic, endemic, iatrogenic, and the epidemic are the main ones. Several histologic disease morphologies have been described, such as inflammatory, angiomatous, spindle cell, mixed, and the anaplastic (sarcomatous) subtypes. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000213DOI Listing
March 2019
8 Reads

Cutaneous Lymphoproliferative Disorders: What's New in the Revised 4th Edition of the World Health Organization (WHO) Classification of Lymphoid Neoplasms.

Authors:
Uma Sundram

Adv Anat Pathol 2019 Mar;26(2):93-113

Department of Anatomic Pathology, Oakland University William Beaumont School of Medicine and Beaumont Health Systems, Royal Oak, MI.

Cutaneous lymphoproliferative disorders remain a challenging aspect of dermatopathology, in part due to the rarity of the entities and extreme variability in clinical outcomes. Although many of the entities remain unchanged, the approach to some of them has changed in the new 2016 classification scheme of the World Health Organization. Chief among these are Epstein-Barr virus-associated lymphoproliferative disorders such as Epstein-Barr virus-associated mucocutaneous ulcer and hydroa vacciniforme-like lymphoproliferative disorder, primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma, primary cutaneous acral CD8+ T-cell lymphoma, primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder, and breast implant-associated anaplastic large cell lymphoma. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000208DOI Listing
March 2019
22 Reads

Diagnostic and Predictive Immunohistochemistry for Non-Small Cell Lung Carcinomas.

Adv Anat Pathol 2018 Nov;25(6):374-386

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Non-small cell lung carcinoma (NSCLC) accounts for significant morbidity and mortality worldwide, with most patients diagnosed at advanced stages and managed increasingly with targeted therapies and immunotherapy. In this review, we discuss diagnostic and predictive immunohistochemical markers in NSCLC, one of the most common tumors encountered in surgical pathology. We highlight 2 emerging diagnostic markers: nuclear protein in testis (NUT) for NUT carcinoma; SMARCA4 for SMARCA4-deficient thoracic tumors. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000206DOI Listing
November 2018
19 Reads

Immunohistochemistry in Surgical Pathology.

Adv Anat Pathol 2018 11;25(6):373

Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1097/PAP.0000000000000212DOI Listing
November 2018
3 Reads

Applications of Immunohistochemistry to Endocrine Pathology.

Adv Anat Pathol 2018 Nov;25(6):413-429

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

The role of immunohistochemistry (IHC) in endocrine pathology is similar to that in other organ systems in that it can aid in the subclassification of tumors within an organ, confirm site of primary in metastatic disease, provide prognostic information, identify underlying genetic alterations, and predict response to treatment. Although most endocrine tumors do not require IHC to render a diagnosis, there are certain scenarios in which IHC can be extremely helpful. For example, in thyroid, IHC can be used to support tumor dedifferentiation, in the adrenal it can aid in the diagnosis of low-grade adrenocortical carcinomas, and in paragangliomas it can help identify tumors arising as part of an inherited tumor syndrome. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000209DOI Listing
November 2018
2 Reads

Immunohistochemical Pitfalls in Genitourinary Pathology: 2018 Update.

Adv Anat Pathol 2018 Nov;25(6):387-399

Robert J. Tomsich Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH.

Immunohistochemistry may be a very useful adjunct to morphologic diagnosis in many areas of surgical pathology, including genitourinary pathology. In this review, we address common diagnostic dilemmas where immunophenotypic analysis may be utilized and we highlight pitfalls specific to each scenario. For prostate, we review the diagnosis of limited prostatic adenocarcinoma and the distinction of high-grade prostatic adenocarcinoma from urothelial carcinoma. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000205DOI Listing
November 2018
7 Reads

Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.

Adv Anat Pathol 2018 Nov;25(6):400-412

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Although some soft tissue and bone tumors can be identified based on histologic features alone, immunohistochemistry plays a critical diagnostic role for most mesenchymal tumor types. The discovery of recurrent genomic alterations in many benign and malignant mesenchymal neoplasms has added important biologic insights and expanded the spectrum of some diagnostic subgroups. Some tumors are defined by unique genomic alterations, whereas others share abnormalities that are not tumor-specific and can be observed in a sometimes broad range of biologically unrelated neoplasms. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442933PMC
November 2018
19 Reads

Current CPT Coding and Payment Policy Implications for Immunohistology Services.

Adv Anat Pathol 2018 Nov;25(6):430-433

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Immunohistology is essential to the practice of modern surgical and cytopathology. There are 3 major types of immunohistologic services provided in clinical practice: traditional immunohistochemistry, morphometric analysis of tumor immunohistochemistry, and immunofluorescence. Proper Current Procedural Terminology coding for these services has been updated to reflect current medical practice. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000207DOI Listing
November 2018
3 Reads

Urologic Diseases Germane to the Medical Renal Biopsy: Review of a Large Diagnostic Experience in the Context of the Renal Architecture and Its Environs.

Authors:
Stephen M Bonsib

Adv Anat Pathol 2018 Sep;25(5):333-352

Arkana Laboratories, Little Rock, AR.

The kidney is one of the most complicated organs in development and is susceptible to more types of diseases than other organs. The disease spectrum includes developmental and cystic diseases, involvement by systemic diseases, iatrogenic complications, ascending infections and urinary tract obstruction, and neoplastic diseases. The diagnosis of kidney disease is unique involving 2 subspecialties, urologic pathology and renal pathology. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086223PMC
September 2018
9 Reads

Pulmonary Sarcomatoid Carcinomas: A Review.

Adv Anat Pathol 2018 Sep;25(5):304-313

Department of Pathology, MD Anderson Cancer Center, Houston, TX.

Pulmonary sarcomatoid carcinomas belong to a group of neoplasms that remain incompletely understood. They are rare tumors of the bronchopulmonary system that incorporate a wide range of neoplasms that by definition contain a sarcomatoid component characterized by spindle or giant cells. Such classification has led to a heterogenous tumor category that includes neoplasms with different clinical, morphologic, and prognostic features. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000202DOI Listing
September 2018
24 Reads

Neoplasms of the Neuroendocrine Pancreas: An Update in the Classification, Definition, and Molecular Genetic Advances.

Adv Anat Pathol 2019 Jan;26(1):13-30

Departments of Pathology, Massachusetts General Hospital, Boston, MA.

This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly differentiated pancreatic neuroendocrine carcinoma (panNEC), and incorporates a new subcategory of "well-differentiated high-grade NET (G3)" to the well-differentiated NET category. This new classification algorithm aims to improve the prediction of clinical outcomes and survival and help clinicians select better therapeutic strategies for patient care and management. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000201DOI Listing
January 2019
28 Reads

Ewing Sarcoma and the History of Similar and Possibly Related Small Round Cell Tumors: From Whence Have We Come and Where are We Going?

Adv Anat Pathol 2018 Sep;25(5):314-326

Department of Anatomic Pathology/L25, Cleveland Clinic, Cleveland, OH.

The diagnosis of small round cell tumors always has been extremely difficult, and our current classification systems continue to evolve. Since its initial discovery by Dr James Ewing, the historical context of what is acceptably included under the designation "Ewing sarcoma" has changed. Although Ewing sarcoma and primitive neuroectodermal tumor were both initially described in the early 20th century, these tumors were considered likely distinct entities until the end of that same century, almost 75 years later. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000203DOI Listing
September 2018
14 Reads

Evolution in Prostate Cancer Staging: Pathology Updates From AJCC 8th Edition and Opportunities That Remain.

Authors:
Samson W Fine

Adv Anat Pathol 2018 Sep;25(5):327-332

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

The Tumor-Nodes-Metastasis system at the core of prognostic staging has been recently updated in the American Joint Committee on Cancer (AJCC) 8th edition, published in 2016. For prostate cancer, significant changes in staging of organ-confined disease, inclusion of a new grade grouping, and provision of levels of evidence for these modifications are part of what differentiates the 8th edition AJCC from prior iterations. Herein, the rationale underlying these changes is detailed. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000200DOI Listing
September 2018
4 Reads

Recent Advances in the Diagnosis and Pathogenesis of Neurofibromatosis Type 1 (NF1)-associated Peripheral Nervous System Neoplasms.

Adv Anat Pathol 2018 Sep;25(5):353-368

Department of Pathology and Laboratory Medicine.

The diagnosis of a neurofibroma or a malignant peripheral nerve sheath tumor (MPNST) often raises the question of whether the patient has the genetic disorder neurofibromatosis type 1 (NF1) as well as how this will impact the patient's outcome, what their risk is for developing additional neoplasms and whether treatment options differ for NF1-associated and sporadic peripheral nerve sheath tumors. Establishing a diagnosis of NF1 is challenging as this disorder has numerous neoplastic and non-neoplastic manifestations which are variably present in individual patients. Further, other genetic diseases affecting the Ras signaling cascade (RASopathies) mimic many of the clinical features of NF1. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000197DOI Listing
September 2018
12 Reads

Recent Advances in the Classification of Low-grade Papillary-like Thyroid Neoplasms and Aggressive Papillary Thyroid Carcinomas: Evolution of Diagnostic Criteria.

Adv Anat Pathol 2018 Jul;25(4):263-272

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI.

Papillary thyroid carcinomas account for ∼80% of well-differentiated thyroid tumors. During the past decade, several new variants of papillary-like thyroid neoplasms and papillary thyroid carcinomas have been recognized. Some of these neoplasms that were previously classified as malignant have been reclassified as low-grade neoplasms, as the diagnostic criteria have evolved. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000198DOI Listing
July 2018
8 Reads

Selected Case From the Arkadi M. Rywlin International Pathology Slide Club: Peritoneal Lipofuscinosis and Deciduosis in Pregnancy.

Adv Anat Pathol 2018 Sep;25(5):369-371

The Department of Anatomical Pathology, SA Pathology at Flinders Medical Centre, Bedford Park, SA, Australia.

Peritoneal lipofuscinosis is a very rarely recognized condition occurring during pregnancy characterized by brown pigmentation of the omentum and peritoneum, a decidual reaction and benign mesothelial cells. The iron negative pigment, which is likely to be confused with hemosiderin in the hematoxylin and eosin stain, is lipofuscin. The seminar case, apparently the third published, arose in a 37-year-old woman who presented in October 2015 at 24 weeks pregnancy with abdominal pain. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000193DOI Listing
September 2018
14 Reads

Unfavorable Pathology, Tissue Biomarkers and Genomic Tests With Clinical Implications in Prostate Cancer Management.

Adv Anat Pathol 2018 Sep;25(5):293-303

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic.

Prostate cancer management has traditionally relied upon risk stratification of patients based on Gleason score, pretreatment prostate-specific antigen and clinical tumor stage. However, these factors alone do not adequately reflect the inherent complexity and heterogeneity of prostate cancer. Accurate and individualized risk stratification at the time of diagnosis is instrumental to facilitate clinical decision-making and treatment selection tailored to each patient. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000192DOI Listing
September 2018
6 Reads

Fluorescent In Situ Hybridization in Surgical Pathology Practice.

Adv Anat Pathol 2018 Jul;25(4):223-237

Royal Prince Alfred Hospital, Sydney Medical School, University of Sydney.

There have been rapid and significant advances in diagnostic and predictive molecular techniques in recent years with profound impact on patient care. In situ hybridization (ISH) studies have become well entrenched in surgical pathology practice and their role in the evaluation of HER2 in breast carcinoma and their diagnostic utility in soft tissue pathology are well known. Fluorescent ISH is being increasingly used in other sites such as the head and neck and the gynecologic tract. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000194DOI Listing
July 2018
6 Reads
3.230 Impact Factor

An Update on the Clinicopathologic Features and Pathologic Diagnosis of Hepatitis E in Liver Specimens.

Adv Anat Pathol 2018 Jul;25(4):273-281

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Infection with the hepatitis E virus (HEV) is globally seen a leading cause of hepatitis. Now increasingly recognized also in industrialized countries, hepatitis E constitutes a significant health problem worldwide. The patient's immune status determines the clinical course and histopathology of hepatitis E. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000195DOI Listing
July 2018
31 Reads

Tumor Syndromes Predisposing to Osteosarcoma.

Adv Anat Pathol 2018 Jul;25(4):217-222

Department of Pathology, Memorial Sloan Kettering Cancer Center, NewYork, NY.

Osteosarcoma (OS) is the most common primary bone tumor affecting predominantly adolescents and young adults. It accounts for about 5% of all childhood cancers. Although the majority of OSs are sporadic, a small percentage occur as a component of hereditary cancer syndromes. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000190DOI Listing
July 2018
7 Reads

Cutaneous Smooth Muscle Tumors: A Review.

Adv Anat Pathol 2018 Jul;25(4):282-290

Southern California Permanente Medical Group, Department of Pathology, Orange County-Anaheim Medical Center, Anaheim, CA.

Smooth muscle tumors occur infrequently in the skin. They consist of a diverse group of lesions representing hamartomas as well as benign and malignant neoplasms. They may arise from arrector pili muscle, specialized smooth muscle of the genitalia, or vascular smooth muscle. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000188DOI Listing
July 2018
12 Reads

Atypical Hepatocellular Neoplasms: Review of Clinical, Morphologic, Immunohistochemical, Molecular, and Cytogenetic Features.

Adv Anat Pathol 2018 Jul;25(4):254-262

Department of Pathology, University of California at San Francisco, San Francisco, CA.

The distinction of hepatocellular adenoma from well-differentiated hepatocellular carcinoma (HCC) can be difficult in some cases, especially on biopsy specimens. These borderline cases often occur in men or older patients and may have β-catenin activation or focal atypical morphologic features (such as small cell change, prominent pseudoacinar formation, cytologic atypia, focally thick plates, and/or focal reticulin loss) that are insufficient for an unequivocal diagnosis of HCC. The term "atypical hepatocellular neoplasm" has been advocated for these tumors, but a number of other terms, including "atypical adenoma," "hepatocellular neoplasm of uncertain malignant potential," and "well-differentiated hepatocellular neoplasm with atypical or borderline features" have also been proposed. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000189DOI Listing
July 2018
8 Reads

Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics.

Adv Anat Pathol 2018 May;25(3):143-171

Department of Pathology, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.

Recent advances in molecular pathology have reshaped the practice of brain tumor diagnostics. The classification of gliomas has been restructured with the discovery of isocitrate dehydrogenase (IDH) 1/2 mutations in the vast majority of lower grade infiltrating gliomas and secondary glioblastomas (GBM), with IDH-mutant astrocytomas further characterized by TP53 and ATRX mutations. Whole-arm 1p/19q codeletion in conjunction with IDH mutations now define oligodendrogliomas, which are also enriched for CIC, FUBP1, PI3K, NOTCH1, and TERT-p mutations. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000186DOI Listing
May 2018
6 Reads

Molecular and Metabolic Basis of Clear Cell Carcinoma of the Kidney.

Adv Anat Pathol 2018 May;25(3):189-196

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Renal cell carcinoma (RCC) is a heterogenous group of tumors, >70% of which belong to the category of clear cell carcinoma. In recent years, crucial advances have been made in our understanding of the molecular and metabolic basis of clear cell carcinoma. This tumor manifests significant alterations in the cellular metabolism, so that the tumor cells preferentially induce the hypoxia response pathway using aerobic glycolysis, rather than the normal oxidative phosphorylation for energy. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000185DOI Listing
May 2018
8 Reads

Pathologic Features of Infectious Gastritis.

Adv Anat Pathol 2018 Jul;25(4):238-253

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA.

This manuscript presents a review of infectious causes of gastritis aimed at the practicing anatomic pathologist. We shall highlight unique histologic findings and clinical attributes that will assist those analyzing endoscopically obtained mucosal biopsies of the stomach or resection specimens. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000187DOI Listing
July 2018
9 Reads

HPV-related Oropharyngeal Carcinoma: A Review of Clinical and Pathologic Features With Emphasis on Updates in Clinical and Pathologic Staging.

Adv Anat Pathol 2018 May;25(3):180-188

Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital.

There has been a sharp increase in the incidence of the human papilloma virus-related oropharyngeal squamous cell carcinoma, partly due to the increasingly widespread awareness and recognition of this entity. This review assimilates the recent histopathologic classifications, staging systems, rapidly expanding research base and developments in management of human papilloma virus-related oropharyngeal squamous cell carcinoma and summarizes their implications for routine diagnostic practice. Differential diagnoses and their cytologic appearances are detailed and the utility of p16 staining and other immunohistochemistry testing is discussed. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000179DOI Listing
May 2018
9 Reads

Disclosure of Harmful Medical Error to Patients: A Review With Recommendations for Pathologists.

Adv Anat Pathol 2018 Mar;25(2):124-130

Department of Pathology at Beth Israel Deaconess Medical Center.

Harmful error is an infrequent but serious challenge in the pathology laboratory. Regulatory bodies and advocacy groups have mandated and encouraged disclosure of error to patients. Many pathologists are interested in participating in disclosure of harmful error but are ill-equipped to do so. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000181DOI Listing
March 2018
7 Reads