9 results match your criteria Advances in Aging Research

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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.

Alzheimers Dement 2020 01 6;16(1):131-143. Epub 2020 Jan 6.

Association for Frontotemporal Degeneration, Radnor, PA, USA.

Introduction: Frontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60 years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed.

Methods: In March 2018, the Association for Frontotemporal Degeneration convened the Frontotemporal Degeneration Study Group meeting in Washington, DC, to discuss advances in the clinical science of FTLD. Read More

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http://dx.doi.org/10.1016/j.jalz.2019.06.4956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949386PMC
January 2020
1 Read
12.407 Impact Factor

New Perspectives on the Aging Lexicon.

Trends Cogn Sci 2019 08 6;23(8):686-698. Epub 2019 Jul 6.

University of Basel, Basel, Switzerland; Max Planck Institute for Human Development, Berlin, Germany.

The field of cognitive aging has seen considerable advances in describing the linguistic and semantic changes that happen during the adult life span to uncover the structure of the mental lexicon (i.e., the mental repository of lexical and conceptual representations). Read More

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http://dx.doi.org/10.1016/j.tics.2019.05.003DOI Listing
August 2019
1 Read

Symbolic time series analysis of fNIRS signals in brain development assessment.

J Neural Eng 2018 12 12;15(6):066013. Epub 2018 Sep 12.

Institute of Electrical Engineering, Yanshan University, Qinhuangdao 066004, People's Republic of China. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States of America.

Objective: Assessing an infant's brain development remains a challenge for neuroscientists and pediatricians despite great technological advances. As a non-invasive neuroimaging tool, functional near-infrared spectroscopy (fNIRS) has great advantages in monitoring an infant's brain activity. To explore the dynamic features of hemodynamic changes in infants, in-pattern exponent (IPE), anti-pattern exponent (APE), as well as permutation cross-mutual information (PCMI) based on symbolic dynamics are proposed to measure the phase differences and coupling strength in oxyhemoglobin (HbO) and deoxyhemoglobin (Hb) signals from fNIRS. Read More

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http://dx.doi.org/10.1088/1741-2552/aae0c9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239960PMC
December 2018
30 Reads

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.

Alzheimers Dement 2017 Apr 22;13(4):e1-e85. Epub 2017 Mar 22.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Introduction: The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued development and standardization of methodologies for biomarkers and has provided an increased depth and breadth of data available to qualified researchers. This review summarizes the over 400 publications using ADNI data during 2014 and 2015.

Methods: We used standard searches to find publications using ADNI data. Read More

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http://dx.doi.org/10.1016/j.jalz.2016.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818723PMC
April 2017
52 Reads

Role of Physical Exercise, Education and Work Related Measures with the Longevity of Work in Older Population in United States.

Adv Aging Res 2017 Jan 13;6(1):1-10. Epub 2016 Dec 13.

College of Arts and Sciences, American University, Washington DC, USA.

Growth of older population in United States (US) raises concerns for evaluation of health indices that could sustain their workability. This study aimed to characterize the association of health practices used by older working population and measures of quality and duration of their work. Forty (40) non-treatment seeking healthy working individuals residing within United States within 22 - 75 years of age were included in this study. Read More

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http://dx.doi.org/10.4236/aar.2017.61001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179220PMC
January 2017
4 Reads

Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities.

Health Aff (Millwood) 2016 08;35(8):1367-73

José M. Ordovás is director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

Evidence shows that both biological and nonbiological factors contribute to health disparities. Genetics, in particular, plays a part in how common diseases manifest themselves. Today, unprecedented advances in genetically based diagnoses and treatments provide opportunities for personalized medicine. Read More

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http://dx.doi.org/10.1377/hlthaff.2015.1476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100696PMC
August 2016
31 Reads

CE: critical care recovery center: an innovative collaborative care model for ICU survivors.

Am J Nurs 2015 Mar;115(3):24-31; quiz 34, 46

Babar A. Khan is an assistant professor at the Indiana University School of Medicine in Indianapolis, where Malaz A. Boustani is a professor. Khan and Boustani are also affiliated with the Indiana University Center for Aging Research and with the Regenstrief Institute, Inc., also in Indianapolis. Sue Lasiter is an assistant professor at the Indiana University School of Nursing. The authors acknowledge Lisa Hovious for her role as a care coordinator at the Critical Care Recovery Center (CCRC). The CCRC project received funding from Wishard Health Services. Khan's work on the project was supported through a career development award from the National Institute on Aging (NIA K23-AG043476); Boustani's work was partially supported through a grant from the same institute (R01AG034205). Contact author: Sue Lasiter, The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.

Overview: Five million Americans require admission to ICUs annually owing to life-threatening illnesses. Recent medical advances have resulted in higher survival rates for critically ill patients, who often have significant cognitive, physical, and psychological sequelae, known as postintensive care syndrome (PICS). This growing population threatens to overwhelm the current U. Read More

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http://dx.doi.org/10.1097/01.NAJ.0000461807.42226.3eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608259PMC
March 2015
27 Reads

Evaluation of health determinants for sustaining workability in aging US workforce.

Adv Aging Res 2013 Aug;2(3):106-108

Department of Health Promotion and Management, College of Arts and Sciences, American University, Washington DC, USA.

Growth of older population in United States requires multi-generational evaluation to characterize health measures for sustaining workability. Investigation of measures that working population would need and use with their work-life in an attempt to stay healthy and fit, could potentially reveal significant association that could extend workability and enhance work productivity such as performance, presenteeism, job satisfaction. Evaluation with selective longitudinal health profiling; employment prerequisites; socio-economic and psychological scales could characterize health measures significantly associated with work sustainability. Read More

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http://dx.doi.org/10.4236/aar.2013.23015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180407PMC
August 2013
11 Reads

Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.

Adv Aging Res 2013 May;2(2):72-80

University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA ; Birmingham VA Medical Center, Birmingham, AL, 35233, USA.

Given the protective roles of 25-hydroxyvitamin D (25[OH]D or vitamin D) in musculoskeletal health and the potential beneficial effects of vitamin D supplementation in reducing the risk of various chronic diseases, intensive repletion of vitamin D has been widely advocated. Of note, CD8 T cells have the highest levels of the vitamin D receptor compared with other major immune cells. The effects of vitamin D on CD8 T cells during aging, however, remain unclear. Read More

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http://dx.doi.org/10.4236/aar.2013.22010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226219PMC
May 2013
13 Reads
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