6,661 results match your criteria Advances In Skin & Wound Care[Journal]


Patient reported cosmetic outcome after vacuum assisted excision of benign breast lesions: a cross-sectional study.

Br J Radiol 2020 Jul 10:20190994. Epub 2020 Jul 10.

Department of Radiology, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.

Objective: Better cosmetic outcome after vacuum assisted excision (VAE) compared to surgical excision of benign breast lesions is suggested in previous studies but has never been evaluated with validated outcome measures. In this study patient reported cosmetic outcome after VAEwas evaluated.

Methods: Patients who underwent VAE between July 2017 and December 2018 were invited to complete the cosmetic subscale of the Dutch Breast Cancer Treatment Outcome Scale, comparing the treated with the untreated breast. Read More

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http://dx.doi.org/10.1259/bjr.20190994DOI Listing

Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review.

Molecules 2020 Jul 7;25(13). Epub 2020 Jul 7.

CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.

Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis is a non-invasive, rapid and inexpensive strategy with promising potential in clinical diagnostic procedures. Since cellular metabolism is altered by diseases, the resulting metabolic effects on VOCs may serve as biomarkers for any given pathophysiologic condition. Read More

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http://dx.doi.org/10.3390/molecules25133098DOI Listing

Noninvasive biomarkers for lung cancer diagnosis, where do we stand?

J Thorac Dis 2020 Jun;12(6):3317-3330

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

The 2010's saw demonstration of the power of lung cancer screening to reduce mortality. However, with implementation of lung cancer screening comes the challenge of diagnosing millions of lung nodules every year. When compared to other cancers with widespread screening strategies (breast, colorectal, cervical, prostate, and skin), obtaining a lung nodule tissue biopsy to confirm a positive screening test remains associated with higher morbidity and cost. Read More

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http://dx.doi.org/10.21037/jtd-2019-ndt-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330751PMC

Recent advances in Salamandra skin poison research.

Authors:
Tim Lüddecke

Toxicon 2020 Apr;177 Suppl 1:S6

Fraunhofer Institute for Molecular Biology and Applied Ecology, Animal Venomics Research Group, Winchesterstr. 2, 35394, Gießen, Germany.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.028DOI Listing

Active photonic wireless power transfer into live tissues.

Proc Natl Acad Sci U S A 2020 Jul 6. Epub 2020 Jul 6.

School of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), 61005 Gwangju, Republic of Korea;

Recent advances in soft materials and mechanics activate development of many new types of electrical medical implants. Electronic implants that provide exceptional functions, however, usually require more electrical power, resulting in shorter period of usages although many approaches have been suggested to harvest electrical power in human bodies by resolving the issues related to power density, biocompatibility, tissue damage, and others. Here, we report an active photonic power transfer approach at the level of a full system to secure sustainable electrical power in human bodies. Read More

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http://dx.doi.org/10.1073/pnas.2002201117DOI Listing

Sugary Logistics Gone Wrong: Membrane Trafficking and Congenital Disorders of Glycosylation.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Tumor Immunology Lab, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.

Glycosylation is an important post-translational modification for both intracellular and secreted proteins. For glycosylation to occur, cargo must be transported after synthesis through the different compartments of the Golgi apparatus where distinct monosaccharides are sequentially bound and trimmed, resulting in increasingly complex branched glycan structures. Of utmost importance for this process is the intraorganellar environment of the Golgi. Read More

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http://dx.doi.org/10.3390/ijms21134654DOI Listing

Anti-amoebic potential of azole scaffolds and nanoparticles against pathogenic Acanthamoeba.

Acta Trop 2020 Jul 3:105618. Epub 2020 Jul 3.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.

Acanthamoeba spp. are free living amoeba (FLA) which are widely distributed in nature. They are opportunistic parasites and can cause severe infections to the eye, skin and central nervous system. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105618DOI Listing

CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Anti-proliferative Response in Human Melanoma Cells in vitro and in vivo.

Photochem Photobiol 2020 Jul 4. Epub 2020 Jul 4.

Department of Dermatology, University of Wisconsin, 436 MSC, 1300 University Avenue, Madison, Wisconsin, 53705, USA.

Melanoma is one of the most aggressive, potentially fatal forms of skin cancer, and has been shown to be associated with solar ultraviolet radiation-dependent initiation and progression. Despite remarkable recent advances with targeted- and immune- therapeutics, lasting and recurrence-free survival remain significant concerns. Therefore, additional novel mechanism-based approaches are needed for effective melanoma management. Read More

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http://dx.doi.org/10.1111/php.13305DOI Listing

Photothermal therapy.

J Control Release 2020 Jun 30;325:52-71. Epub 2020 Jun 30.

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. Electronic address:

Microneedles (MNs), as an effective minimally invasive delivery route, when used to puncture the skin, can bypass the skin's stratum corneum (SC) to enter the skin microcirculation and achieve systemic administration. Additionally, the MN route has obvious advantages over other routes of administration, including simplicity, non-pain, readily-permitted transport of drugs (including DNA and metformin) and macromolecules (such as antibodies and proteins), good repeatability, and wide range of clinical applications and safety. MNs have been combined with various therapy strategies including photodynamic therapy (PDT) and photothermal therapy (PTT) to treat many diseases, and hold great promise for improving the diagnosis and treatment of diseases. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.032DOI Listing

Metastatic Basal Cell Carcinoma of the Skin: A Comprehensive Literature Review, Including Advances in Molecular Therapeutics.

Adv Anat Pathol 2020 Jul 1. Epub 2020 Jul 1.

Department of Pathology, The Barzilai Medical Center, Ashkelon, Israel.

Basal cell carcinoma (BCC) of the skin is the most common type of malignant human tumor. In Europe, the incidence of BCC ranges from 44.6 to 128 cases per 100,000 inhabitants annually, whereas in the United States, the yearly incidence rate ranges between 500 and 1500. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000267DOI Listing

Burns in the Elderly: Potential Role of Stem Cells.

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N3M5, Canada.

Burns in the elderly continue to be a challenge despite advances in burn wound care management. Elderly burn patients continue to have poor outcomes compared to the younger population. This is secondary to changes in the quality of the aged skin, leading to impaired wound healing, aggravated immunologic and inflammatory responses, and age-related comorbidities. Read More

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http://dx.doi.org/10.3390/ijms21134604DOI Listing

Endocrinopathies Associated with Immune Checkpoint Inhibitor Cancer Treatment: A Review.

J Clin Med 2020 Jun 29;9(7). Epub 2020 Jun 29.

Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

Treatment with immune checkpoint inhibitors has shown efficacy against a variety of cancer types. The effects of nivolumab and pembrolizumab on lung cancer have been reported, and further therapeutic advances are ongoing. The side effects of immune checkpoint inhibitors are very different from those of conventional cytocidal anticancer drugs and molecular targeted drugs, and they involve various organs such as the digestive and respiratory organs, thyroid and pituitary glands, and skin. Read More

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http://dx.doi.org/10.3390/jcm9072033DOI Listing

3D Printed Electrically-Driven Soft Actuators.

Extreme Mech Lett 2018 May 23;21:1-8. Epub 2018 Feb 23.

Department of Mechanical Engineering, University of Minnesota, 111 Church St. SE, Minneapolis, MN 55455, USA.

Soft robotics is an emerging field enabled by advances in the development of soft materials with properties commensurate to their biological counterparts, for the purpose of reproducing locomotion and other distinctive capabilities of active biological organisms. The development of soft actuators is fundamental to the advancement of soft robots and bio-inspired machines. Among the different material systems incorporated in the fabrication of soft devices, ionic hydrogel-elastomer hybrids have recently attracted vast attention due to their favorable characteristics, including their analogy with human skin. Read More

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http://dx.doi.org/10.1016/j.eml.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319180PMC

Emerging Role of Elastin-Like Polypeptides (ELPs) in Regenerative Medicine.

Adv Wound Care (New Rochelle) 2020 Jun 30. Epub 2020 Jun 30.

All India Institute of Medical Sciences, 28730, Pathology, New Delhi, India;

Significance: Wound dressing based on naturally derived polymer provides a useful platform for the treatment of skin injuries. Owing to the high mechanical strength, tunable structural and physicochemical properties of human elastin-like polypeptides (ELPs), they may be used as excellent material for fabricating biocompatible scaffold and other products for wound management. Recent Advances: Designing recombinant ELPs mimicking the natural elastin to fabricate synthetic polymers suitable for human health care has generated significant interest. Read More

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http://dx.doi.org/10.1089/wound.2019.1085DOI Listing

Advances in Antimicrobial Microneedle Patches for Combating Infections.

Adv Mater 2020 Jun 29:e2002129. Epub 2020 Jun 29.

Institute for Polymers, Composites, and Biomaterials (IPCB), National Research Council (CNR), Naples, 80125, Italy.

Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. Read More

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http://dx.doi.org/10.1002/adma.202002129DOI Listing

Rapid image deconvolution and multiview fusion for optical microscopy.

Nat Biotechnol 2020 Jun 29. Epub 2020 Jun 29.

Laboratory of High-Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.

The contrast and resolution of images obtained with optical microscopes can be improved by deconvolution and computational fusion of multiple views of the same sample, but these methods are computationally expensive for large datasets. Here we describe theoretical and practical advances in algorithm and software design that result in image processing times that are tenfold to several thousand fold faster than with previous methods. First, we show that an 'unmatched back projector' accelerates deconvolution relative to the classic Richardson-Lucy algorithm by at least tenfold. Read More

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http://dx.doi.org/10.1038/s41587-020-0560-xDOI Listing

Common signal transduction molecules activated by bacterial entry into a host cell and by reactive oxygen species.

Antioxid Redox Signal 2020 Jun 29. Epub 2020 Jun 29.

Pineta Grande Hospital, Caserta, Italy;

Significance: An increasing number of pathogens are acquiring resistance to antibiotics. Efficient antimicrobial drug regimens are important even for the most advanced therapies, which range from cutting-edge invasive clinical protocols, such as robotic surgeries, to the treatment of harmless bacterial diseases and to minor scratches to the skin. Therefore, there is an urgent need to survey alternative antimicrobial drugs that can reinforce or replace existing antibiotics. Read More

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http://dx.doi.org/10.1089/ars.2019.7968DOI Listing

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using "Soft" Colloidal Nanocarriers.

Pharmaceutics 2020 Jun 24;12(6). Epub 2020 Jun 24.

Department of Physical and Quantum Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.

The growing demand for effective delivery of photosensitive active compounds has resulted in the development of colloid chemistry and nanotechnology. Recently, many kinds of novel formulations with outstanding pharmaceutical potential have been investigated with an expansion in the design of a wide variety of "soft" nanostructures such as simple or multiple (double) nanoemulsions and lipid formulations. The latter can then be distinguished into vesicular, including liposomes and "smart" vesicles such as transferosomes, niosomes and ethosomes, and non-vesicular nanosystems with solid lipid nanoparticles and nanostructured lipid carriers. Read More

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http://dx.doi.org/10.3390/pharmaceutics12060587DOI Listing

Holistically Engineered Polymer-Polymer and Polymer-Ion Interactions in Biocompatible Polyvinyl Alcohol Blends for High-Performance Triboelectric Devices in Self-Powered Wearable Cardiovascular Monitorings.

Adv Mater 2020 Jun 28:e2002878. Epub 2020 Jun 28.

School of Industrial Engineering, Purdue University, West Lafayette, IN, 47907, USA.

The capability of sensor systems to efficiently scavenge their operational power from stray, weak environmental energies through sustainable pathways could enable viable schemes for self-powered health diagnostics and therapeutics. Triboelectric nanogenerators (TENG) can effectively transform the otherwise wasted environmental, mechanical energy into electrical power. Recent advances in TENGs have resulted in a significant boost in output performance. Read More

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http://dx.doi.org/10.1002/adma.202002878DOI Listing

Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis.

F1000Res 2020 16;9. Epub 2020 Jun 16.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases characterized by detachment of the epidermis and mucous membrane. SJS/TEN are considered to be on the same spectrum of diseases with different severities. They are classified by the percentage of skin detachment area. Read More

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http://dx.doi.org/10.12688/f1000research.24748.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308994PMC

Recent advances in understanding the molecular basis of melanogenesis in melanocytes.

F1000Res 2020 15;9. Epub 2020 Jun 15.

Laboratory of Membrane Trafficking Mechanisms, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi 980-8578, Japan.

Melanin pigments are responsible for human skin and hair color, and they protect the body from harmful ultraviolet light. The black and brown melanin pigments are synthesized in specialized lysosome-related organelles called melanosomes in melanocytes. Mature melanosomes are transported within melanocytes and transferred to adjacent keratinocytes, which constitute the principal part of human skin. Read More

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http://dx.doi.org/10.12688/f1000research.24625.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308992PMC

Vibration detection: its function and recent advances in medical applications.

F1000Res 2020 17;9. Epub 2020 Jun 17.

Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands.

Vibrations are all around us. We can detect vibrations with sensitive skin mechanoreceptors, but our conscious awareness of the presence of vibrations is often limited. Nevertheless, vibrations play a role in our everyday life. Read More

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http://dx.doi.org/10.12688/f1000research.22649.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308885PMC

Desmoplastic melanoma: an updated clinical review and the emerging role of genetic markers and immunotherapies.

Melanoma Res 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, University of Connecticut, Farmington, Connecticut.

Desmoplastic melanoma (DM) is a rare and histopathologically as well as prognostically distinct subset of melanoma that arises in chronically sun-damaged skin. DM is typically and relatively indolent in nature with most cases not progressing to metastatic disease. DM has been managed with both radiation and surgical approaches. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000679DOI Listing

Recent insights into the role of L1CAM in cancer initiation and progression.

Int J Cancer 2020 Jun 25. Epub 2020 Jun 25.

Institute for Experimental Cancer Research, Kiel University and University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.

First described as a neuronal cell adhesion molecule, L1CAM was later identified to be present at increased levels in primary tumors and metastases of various types of cancer. Here, we describe the multifaceted roles of L1CAM that are involved in diverse fundamental steps during tumor initiation and progression, as well as in chemoresistance. Recently, Ganesh et al. Read More

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http://dx.doi.org/10.1002/ijc.33177DOI Listing
June 2020
5.085 Impact Factor

Imunofan-RDKVYR Peptide-Stimulates Skin Cell Proliferation and Promotes Tissue Repair.

Molecules 2020 Jun 23;25(12). Epub 2020 Jun 23.

Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, 80-308 Gdańsk, Poland.

Regeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. Read More

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http://dx.doi.org/10.3390/molecules25122884DOI Listing

Arthroscopic Vastus Elevation (AVE) for Arthrofibrosis of the Knee: Surgical Technique and Literature Review.

J Surg Orthop Adv 2020 ;29(2):117-120

Loma Linda University Medical Center, Department of Orthopaedic Surgery, Loma Linda, California.

Arthrofibrosis of the knee continues to challenge Orthopaedic surgeons. With a wide etiology, lack of knee motion can be debilitating. Its surgical management has several complications. Read More

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January 2020

Melatonin: an endogenous miraculous indolamine, fights against cancer progression.

Authors:
Saptadip Samanta

J Cancer Res Clin Oncol 2020 Aug 24;146(8):1893-1922. Epub 2020 Jun 24.

Department Physiology, Midnapore College, Paschim Medinipur, Midnapore, West Bengal, 721101, India.

Purpose: Melatonin is an amphipathic indolamine molecule ubiquitously present in all organisms ranging from cyanobacteria to humans. The pineal gland is the site of melatonin synthesis and secretion under the influence of the retinohypothalamic tract. Some extrapineal tissues (skin, lens, gastrointestinal tract, testis, ovary, lymphocytes, and astrocytes) also enable to produce melatonin. Read More

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http://dx.doi.org/10.1007/s00432-020-03292-wDOI Listing

Electrospun Biomaterials in the Treatment and Prevention of Scars in Skin Wound Healing.

Front Bioeng Biotechnol 2020 3;8:481. Epub 2020 Jun 3.

Gastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

Electrospinning is a promising method for the rapid and cost-effective production of nanofibers from a wide variety of polymers given the high surface area morphology of these nanofibers, they make excellent wound dressings, and so have significant potential in the prevention and treatment of scars. Wound healing and the resulting scar formation are exceptionally well-characterized on a molecular and cellular level. Despite this, novel effective anti-scarring treatments which exploit this knowledge are still clinically absent. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283777PMC

Pulmonary Hypertension Phenotypes in Systemic Sclerosis: The Right Diagnosis for the Right Treatment.

Int J Mol Sci 2020 Jun 22;21(12). Epub 2020 Jun 22.

Department of Translational Medical Sciences. Federico II University, 80131 Naples, Italy.

Systemic sclerosis is an auto-immune disease characterized by skin involvement that often affects multiple organ systems. Pulmonary hypertension is a common finding that can significantly impact prognosis. Molecular pathophysiological mechanisms underlying pulmonary hypertension in systemic sclerosis can be extremely heterogeneous, leading to distinct clinical phenotypes. Read More

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http://dx.doi.org/10.3390/ijms21124430DOI Listing

Human-computer collaboration for skin cancer recognition.

Nat Med 2020 Jun 22. Epub 2020 Jun 22.

ViDIR Group, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

The rapid increase in telemedicine coupled with recent advances in diagnostic artificial intelligence (AI) create the imperative to consider the opportunities and risks of inserting AI-based support into new paradigms of care. Here we build on recent achievements in the accuracy of image-based AI for skin cancer diagnosis to address the effects of varied representations of AI-based support across different levels of clinical expertise and multiple clinical workflows. We find that good quality AI-based support of clinical decision-making improves diagnostic accuracy over that of either AI or physicians alone, and that the least experienced clinicians gain the most from AI-based support. Read More

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http://dx.doi.org/10.1038/s41591-020-0942-0DOI Listing

A deep learning, image based approach for automated diagnosis for inflammatory skin diseases.

Ann Transl Med 2020 May;8(9):581

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, China.

Background: As the booming of deep learning era, especially the advances in convolutional neural networks (CNNs), CNNs have been applied in medicine fields like radiology and pathology. However, the application of CNNs in dermatology, which is also based on images, is very limited. Inflammatory skin diseases, such as psoriasis (Pso), eczema (Ecz), and atopic dermatitis (AD), are very easily to be mis-diagnosed in practice. Read More

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http://dx.doi.org/10.21037/atm.2020.04.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290553PMC

Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease.

Curr Rheumatol Rep 2020 Jun 19;22(8):33. Epub 2020 Jun 19.

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.

Purpose Of Review: Fibroblasts, the major cell population in all connective tissues, are best known for their role in depositing and maintaining the extracellular matrix. Recently, numerous specialised functions have been discovered revealing unpredicted fibroblast heterogeneity. We will discuss this heterogeneity, from its origins in development to alterations in fibrotic disease conditions. Read More

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http://dx.doi.org/10.1007/s11926-020-00903-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305072PMC

Transfusion and Infections in the Burn Patient.

Authors:
Tina L Palmieri

Surg Infect (Larchmt) 2020 Jun 19. Epub 2020 Jun 19.

Department of Surgery, University of California, Davis, Sacramento, California, USA.

Blood product transfusion has historically been utilized after major burn injury in the resuscitative as well as the acute phase. Transfusion has been implicated in infection and immunosuppression in many disease states. Recommendations for blood product transfusion has varied, but several landmark studies have helped define optimal burn transfusion strategies with respect to infection. Read More

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http://dx.doi.org/10.1089/sur.2020.160DOI Listing

Focal therapy for prostate cancer: recent advances and future directions.

Clin Adv Hematol Oncol 2020 Feb;18(2):116-125

Urologic Oncology Branch, National Cancer Institute at the National Institutes of Health, Bethesda, Maryland.

Prostate cancer is the most frequently diagnosed cancer in men after skin cancer. Owing to the rising popularity of prostate-specific antigen screening, large numbers of patients are receiving a diagnosis of prostate cancer and undergoing whole-gland treatment. Some patients with a diagnosis of low-risk, localized disease may not benefit from whole-gland treatment, however, given its known morbidity. Read More

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February 2020

Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue.

Aging (Albany NY) 2020 Jun 18;12(12):12393-12409. Epub 2020 Jun 18.

Institute for Bioinformatics, University Medicine Greifswald, Greifswald, Germany.

In recent years, reports of non-linear regulations in age- and longevity-associated biological processes have been accumulating. Inspired by methodological advances in precision medicine involving the integrative analysis of multi-omics data, we sought to investigate the potential of multi-omics integration to identify distinct stages in the aging progression from human skin tissue. For this we generated transcriptome and methylome profiling data from suction blister lesions of female subjects between 21 and 76 years, which were integrated using a network fusion approach. Read More

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http://dx.doi.org/10.18632/aging.103499DOI Listing

New testosterone 2% gel using Ferring Advanced Skin Technology (FAST), for the treatment of testosterone deficiency in men, with a novel applicator.

Expert Rev Endocrinol Metab 2020 Jul 17;15(4):217-226. Epub 2020 Jun 17.

University Hospitals Birmingham NHS Foundation Trust , Birmingham, UK.

Introduction: Testosterone deficiency (TD) is an increasing problem that can affect a man's physical and psychological health, and quality of life. Testosterone replacement therapy (TRT), combined with weight reduction, lifestyle advice, and the treatment of co-morbidities, is the treatment of choice in men who are not concerned about fertility. However, there remains an unmet need in this therapeutic area, relating to factors such as inconvenient or painful administration, fluctuations in testosterone levels, supra-physiologic testosterone levels, poor tolerability, and secondary safety issues, which may be associated with the current TRT options. Read More

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http://dx.doi.org/10.1080/17446651.2020.1773259DOI Listing

The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020.

Cancers (Basel) 2020 Jun 11;12(6). Epub 2020 Jun 11.

Head and Neck Tumor Center, Hollings Cancer Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

Cancers that arise in the head and neck region are comprised of a heterogeneous group of malignancies that include carcinogen- and human papillomavirus (HPV)-driven mucosal squamous cell carcinoma as well as skin cancers such as cutaneous squamous cell carcinoma, basal cell carcinoma, melanoma, and Merkel cell carcinoma. These malignancies develop in critical areas for eating, talking, and breathing and are associated with substantial morbidity and mortality despite advances in treatment. Understanding of advances in the management of these various cancers is important for all multidisciplinary providers who care for patients across the cancer care continuum. Read More

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http://dx.doi.org/10.3390/cancers12061543DOI Listing

Patient-Centered Health Education Intervention to Empower Preventive Diabetic Foot Self-care.

Adv Skin Wound Care 2020 Jul;33(7):360-365

Meryl Makiling, RN, is Staff Nurse, HVI-Podiatry Clinic, Cleveland Clinic, Abu Dhabi, United Arab Emirates. Hiske Smart, CNS, is Clinical Nurse Specialist, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain. The authors have disclosed no financial relationships related to this article. This article was originally published as Makiling M, Smart H. Patient-centred health educational intervention to empower preventive diabetic foot self-care. WCET J 2019;39(4):32-40. © Advances in Skin and Wound Care and World Council of Enterostomal Therapists.

Background: Diabetes impairs the body's ability to produce or respond to the hormone insulin resulting in abnormal metabolism of carbohydrates and elevated glucose levels in the body. Because of these factors, diabetes can cause several complications that include heart disease, stroke, hypertension, eye complications, kidney disease, skin complications, vascular disease, nerve damage, and foot problems. Diabetes education allows patients to explore effective interventions into living their life with diabetes and incorporate the necessary changes to improve their lifestyle. Read More

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http://dx.doi.org/10.1097/01.ASW.0000666896.46860.d7DOI Listing

Microbiological detoxification of mycotoxins: Focus on Mechanisms and Advances.

Infect Disord Drug Targets 2020 Jun 16. Epub 2020 Jun 16.

Department of Biochemistry, Biophysics and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari. Iran.

Some fungal species of the genera Aspergillus, Penicillium, and Fusarium secretes toxic metabolites known as mycotoxins, has become a global concern that is toxic to different species of animals and humans. Biological mycotoxins detoxification has been studied by researchers around the world as a new strategy for the mycotoxin removal. Bacteria, fungi, yeast, molds, and protozoa are the main living organisms appropriate for the mycotoxin detoxification. Read More

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http://dx.doi.org/10.2174/1871526520666200616145150DOI Listing

Our natural "makeup" reveals more than it hides: Modeling the skin and its microbiome.

Wiley Interdiscip Rev Syst Biol Med 2020 Jun 15:e1497. Epub 2020 Jun 15.

Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.

Skin is our primary interface with the environment. A structurally and functionally complex organ that hosts a dynamic ecosystem of microbes, and synthesizes many compounds that affect our well-being and psychosocial interactions. It is a natural platform of signal exchange between internal organs, skin resident microbes, and the environment. Read More

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http://dx.doi.org/10.1002/wsbm.1497DOI Listing

Vascularization strategies for skin tissue engineering.

Biomater Sci 2020 Jun 15. Epub 2020 Jun 15.

Department of Chemical Engineering, School of Chemical and Petroleum Engineering, Shiraz University, Shiraz 71348-51154, Iran.

A number of challenges in skin grafting for wound healing have drawn researchers to focus on skin tissue engineering as an alternative solution. The core idea of tissue engineering is to use scaffolds, cells, and/or bioactive molecules to help the skin to properly recover from injuries. Over the past decades, the field has significantly evolved, developing various strategies to accelerate and improve skin regeneration. Read More

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http://dx.doi.org/10.1039/d0bm00266fDOI Listing

Emerging treatments for bullous pemphigoid.

J Dermatolog Treat 2020 Jun 13:1-31. Epub 2020 Jun 13.

Dermatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisbon, Portugal.

Bullous pemphigoid (BP) is the most common autoimmune blistering disease. It is characterized by an immune response against the hemidesmossomal anchoring proteins BP180 and BP230. BP mainly affects elderly patients, with an increasing incidence over the past two decades. Read More

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http://dx.doi.org/10.1080/09546634.2020.1782325DOI Listing

Eosinophils in Bullous Pemphigoid.

Panminerva Med 2020 Jun 12. Epub 2020 Jun 12.

Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA -

Bullous pemphigoid (BP) is an autoimmune blistering disorder with substantial morbidity and mortality. BP is regarded as a disorder driven by IgG due to BP180 and BP230 IgG autoantibodies, yet, new advances highlight the function of eosinophils and IgE autoantibodies in BP. Evidence supports that eosinophils are involved in BP pathogenesis, notably, these include the presence of IL-5, eotaxin, and eosinophil-colony stimulating factor in blister fluid, peripheral blood eosinophilia is present in nearly 50% of affected patients, eosinophils are found against the dermo-epidermal junction (DEJ) when BP serum is present, metalloprotease-9 is secreted by eosinophils at blister sites, blister fluid of BP patients contains eosinophil granule proteins which are located along the lamina lucida of the BMZ in patients with BP and correspond with disease clinically, eosinophil extracellular traps (EET) have been linked to DEJ splitting, IL-5 activated eosinophils cause DEJ separation when BP serum is present, and eosinophils are requisite to drive anti-BP180 IgE mediated blistering of the skin. Read More

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http://dx.doi.org/10.23736/S0031-0808.20.03997-XDOI Listing

Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels.

Commun Biol 2020 Jun 12;3(1):306. Epub 2020 Jun 12.

Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

Melanoma represents the most serious type of skin cancer. Although recent years have seen advances using targeted and immunotherapies, most patients remain at high risk for tumor recurrence. Here we show that IRAK-M, a negative regulator of MyD88 signaling, is deficient or low in melanoma and expression levels correlate with patient survival. Read More

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http://dx.doi.org/10.1038/s42003-020-1033-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293221PMC

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization.

Stem Cell Res Ther 2020 Jun 11;11(1):232. Epub 2020 Jun 11.

Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China.

The skin, which serves as the first barrier of the human body, is particularly susceptible to exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are commonly observed in clinics. Healing of skin wounds is a complex process, consisting of infiltration of inflammatory cells, cellular proliferation, and tissue remodeling phases, which restore the integrity and functions of the skin. Read More

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http://dx.doi.org/10.1186/s13287-020-01755-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291661PMC

Novel Therapeutic Approaches and Targets for Treatment of Atopic Dermatitis.

Curr Pharm Biotechnol 2020 Jun 11. Epub 2020 Jun 11.

Dermatology Unit, Department of Health Sciences, University of Florence, Florence. Italy.

Background: Atopic Dermatitis is one of the most common inflammatory skin diseases , with an estimated prevalence of 2.1-4.9% in adults. Read More

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http://dx.doi.org/10.2174/1389201021666200611112755DOI Listing

The contribution of epigenetics to the pathogenesis and gender dimorphism of systemic sclerosis: a comprehensive overview.

Ther Adv Musculoskelet Dis 2020 6;12:1759720X20918456. Epub 2020 May 6.

Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence and Scleroderma Unit, Azienda Ospedaliero-Universitaria Careggi (AOUC), Florence, Italy.

Systemic sclerosis (SSc) is a life-threatening connective tissue disorder of unknown etiology characterized by widespread vascular injury and dysfunction, impaired angiogenesis, immune dysregulation and progressive fibrosis of the skin and internal organs. Over the past few years, a new trend of investigations is increasingly reporting aberrant epigenetic modifications in genes related to the pathogenesis of SSc, suggesting that, besides genetics, epigenetics may play a pivotal role in disease development and clinical manifestations. Like many other autoimmune diseases, SSc presents a striking female predominance, and even if the reason for this gender imbalance has yet to be completely understood, it appears that the X chromosome, which contains many gender and immune-related genes, could play a role in such gender-biased prevalence. Read More

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http://dx.doi.org/10.1177/1759720X20918456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236401PMC

Hair Follicle Transplantation for Wound Repair.

Authors:
Kristo Nuutila

Adv Wound Care (New Rochelle) 2020 Jun 10. Epub 2020 Jun 10.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Hair follicles are complex miniorgans that reside in the dermal layer of the skin. When the skin is wounded, epidermal stem cells in the hair follicle activate and start migrating into the wound site, differentiating into epidermal cells. and contributing to the reepithelialization of the wound. Read More

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http://dx.doi.org/10.1089/wound.2019.1139DOI Listing

Diagnosis and Treatment of Primary Cutaneous B-Cell Lymphomas: State of the Art and Perspectives.

Cancers (Basel) 2020 06 8;12(6). Epub 2020 Jun 8.

Department of Dermatology, APHP, Saint-Louis Hospital, F-75010 Paris, France.

Primary cutaneous B-cell lymphomas are rare entities that develop primarily in the skin. They constitute a heterogeneous group that represents around a quarter of primary cutaneous lymphomas. The 2018 update of the World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification differentiates primary cutaneous marginal zone lymphoma and primary cutaneous follicle center lymphoma with an indolent course from primary cutaneous diffuse large B-cell lymphoma, leg type with an aggressive behavior. Read More

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http://dx.doi.org/10.3390/cancers12061497DOI Listing

CT-guided radiofrequency ablation for osteoid osteomas: a systematic review.

Eur Radiol 2020 Jun 9. Epub 2020 Jun 9.

Department of Radiology, Langone Orthopedic Hospital, 301 East 17th St, New York, 10021, USA.

Objectives: CT-guided radiofrequency ablation (CT-RFA) is considered to be the gold standard for treatment of osteoid osteoma (OO) yet treatment failures (TFs) continue to be reported. This systematic review was conducted to evaluate factors associated with TF, such as ablation time, lesion location, and patient age as well as evaluating how TF has trended over time.

Methods: Original studies reporting on patients undergoing CT-RFA of OO published between 2002 and 2019 were identified. Read More

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http://dx.doi.org/10.1007/s00330-020-06970-yDOI Listing