5,997 results match your criteria Advances In Skin & Wound Care[Journal]


[Advances in epigenetic markers of dermatomyositis/polymyositis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):374-377

Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Idiopathic inflammatory myopathy (IIM) is a rare group of autoimmune diseases, characterized by chronic muscle weakness, muscle fatigue and infiltration of single nuclear cells in skeletal muscle. Its subtypes include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myositis (IMNM), and the most common subtypes are DM and PM. PM is an autoimmune disease mainly manifested by muscle damage. Read More

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April 2019
1 Read

Intravital imaging of skin infections.

Authors:
Ali Zaid

Cell Immunol 2019 Apr 1. Epub 2019 Apr 1.

Institute for Glycomics, Griffith University Gold Coast Campus, Parklands Drive, Southport, QLD 4215, Australia.

Intravital imaging of cutaneous immune responses has revealed intricate links between the skin's structural properties, the immune cells that reside therein, and the carefully orchestrated migratory dynamics that enable rapid sensing and subsequent elimination of skin pathogens. In particular, the development of 2-photon intravital microscopy (2P-IVM), which enables the excitation of fluorescent molecules within deep tissue with minimal light scattering and tissue damage, has proven an invaluable tool in the characterization of different cell subset's roles in skin infection. The ability to visualize cells, tissue structures, pathogens and track migratory dynamics at designated times following infection, or during inflammatory responses has been crucial in defining how immune responses in the skin are coordinated, either locally or in concert with circulating immune cells. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.04.001DOI Listing

Immune and Inflammatory Reponses to Skin Infections.

Curr Dermatol Rep 2018 Dec 22;7(4):338-349. Epub 2018 Sep 22.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Purpose Of Review: There have been recent advances in our understanding of cutaneous immune responses to the important human skin pathogen, (). This review will highlight these insights into innate and adaptive immune mechanisms in host defense and cutaneous inflammation in response to skin infections.

Recent Findings: Antimicrobial peptides, pattern recognition receptors and inflammasome activation function in innate immunity as well as T cells and their effector cytokines play a key role in adaptive immunity against skin infections. Read More

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http://dx.doi.org/10.1007/s13671-018-0235-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461387PMC
December 2018
1 Read

Analgesic effectiveness of rectus sheath block during open gastrectomy: A prospective double-blinded randomized controlled clinical trial.

Medicine (Baltimore) 2019 Apr;98(15):e15159

Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Background: Despite recent advances in gastric cancer surgery, open gastrectomy is often needed to treat gastric cancer. Due to the large incision in the abdomen, the amount of opioid required during surgery increases and postoperative pain becomes worse. It is well known that postoperative pain has a negative impact on the patient's immune system. Read More

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http://dx.doi.org/10.1097/MD.0000000000015159DOI Listing
April 2019
1 Read

miR-181a/b downregulation exerts a protective action on mitochondrial disease models.

EMBO Mol Med 2019 Apr 12. Epub 2019 Apr 12.

Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy

Mitochondrial diseases (MDs) are a heterogeneous group of devastating and often fatal disorders due to defective oxidative phosphorylation. Despite the recent advances in mitochondrial medicine, effective therapies are still not available for these conditions. Here, we demonstrate that the microRNAs miR-181a and miR-181b (miR-181a/b) regulate key genes involved in mitochondrial biogenesis and function and that downregulation of these miRNAs enhances mitochondrial turnover in the retina through the coordinated activation of mitochondrial biogenesis and mitophagy. Read More

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http://dx.doi.org/10.15252/emmm.201708734DOI Listing
April 2019
3 Reads

Advances in phytochemical delivery systems for improved anticancer activity.

Biotechnol Adv 2019 Apr 9. Epub 2019 Apr 9.

Lake Erie College of Osteopathic Medicine, 5000 Lakewood Ranch Boulevard, Bradenton, FL 34211, USA. Electronic address:

Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.004DOI Listing
April 2019
11 Reads

Dermoscopy use in UK primary care: a survey of GPs with a special interest in dermatology.

J Eur Acad Dermatol Venereol 2019 Apr 12. Epub 2019 Apr 12.

The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, UK.

Background: Melanoma accounts for 90% of skin cancer mortality and typically presents in primary care, where it can be challenging to distinguish from benign lesions. Dermoscopy is a tool for skin visualisation that is routinely used for melanoma diagnosis in secondary care. However, the role of dermoscopy in primary care remains unclear. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15614
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http://dx.doi.org/10.1111/jdv.15614DOI Listing
April 2019
5 Reads

Knowns and unknowns of tissue-resident memory T cells.

Authors:
Daniel M Altmann

Immunology 2019 May;157(1):1-2

Department of Medicine, Hammersmith Hospital, London, UK.

Advances in transcriptomics and other approaches are shedding considerable light on tissue-resident immune cells as distinct from recirculating cells. The advances encompass antigen-presenting cell subsets, Tregs and importantly, tissue-resident memory cells (TRM). What are the transcriptional programmes and functional properties that distinguish the requirements for an effective tissue resident cell in brain relative to lung, skin, adipose tissue or the genital tract? Another important conundrum has been the extent to which TRM cells are specialized either as a 'sense and alarm' population or as a local, primed, effector cell population in themselves. Read More

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http://dx.doi.org/10.1111/imm.13062DOI Listing

Crisaborole 2% Ointment (Eucrisa) for Atopic Dermatitis

Skin Therapy Lett 2019 Mar;24(2):4-6

Division of Dermatology, University of Alberta, Edmonton, AB, Canada

Atopic dermatitis is a common cutaneous disease with significant morbidity affecting children and adults. The mainstay of atopic dermatitis therapy has typically included emollients, topical corticosteroids, and topical calcineurin inhibitors. Among the newer advances recently introduced is crisaborole (Eucrisa™), a phosphodiesterase type-4 inhibitor (PDE-4) for the treatment of mild moderate atopic dermatitis. Read More

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Assessment of Regional Perfusion and Organ Function: Less and Non-invasive Techniques.

Front Med (Lausanne) 2019 22;6:50. Epub 2019 Mar 22.

Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar, Technische Universität München, München, Germany.

Sufficient organ perfusion essentially depends on preserved macro- and micro-circulation. The last two decades brought substantial progress in the development of less and non-invasive monitoring of macro-hemodynamics. However, several recent studies suggest a frequent incoherence of macro- and micro-circulation. Read More

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http://dx.doi.org/10.3389/fmed.2019.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438879PMC

Multiple primary malignancies of six organs in a Japanese male patient: A case report.

Mol Clin Oncol 2019 May 4;10(5):511-515. Epub 2019 Mar 4.

Department of Surgery, Saitama Medical Center, Jichi Medical University, Omiya-ku, Saitama 330-8503, Japan.

As a result of recent advances in diagnostic techniques and treatment modalities, the number of patients diagnosed with multiple primary malignancies has been increasing. We report the case of a 79-year-old male with multiple primary malignancies of three histological types in six different organs: Stomach, prostate, colon, urinary bladder, facial skin and pancreas, in chronological order. The first malignancy was upper gastric cancer diagnosed in 1998. Read More

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http://dx.doi.org/10.3892/mco.2019.1819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449908PMC
May 2019
1 Read

A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies.

Nat Commun 2019 04 9;10(1):1649. Epub 2019 Apr 9.

Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

The recently developed droplet-based single-cell transcriptome sequencing (scRNA-seq) technology makes it feasible to perform a population-scale scRNA-seq study, in which the transcriptome is measured for tens of thousands of single cells from multiple individuals. Despite the advances of many clustering methods, there are few tailored methods for population-scale scRNA-seq studies. Here, we develop a Bayesian mixture model for single-cell sequencing (BAMM-SC) method to cluster scRNA-seq data from multiple individuals simultaneously. Read More

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http://dx.doi.org/10.1038/s41467-019-09639-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456731PMC
April 2019
1 Read

3D Printing Technologies for Flexible Tactile Sensors toward Wearable Electronics and Electronic Skin.

Polymers (Basel) 2018 Jun 7;10(6). Epub 2018 Jun 7.

Additive Manufacturing Institute, College of Mechatronics & Control Engineering, Shenzhen University, Shenzhen 518060, China.

3D printing has attracted a lot of attention in recent years. Over the past three decades, various 3D printing technologies have been developed including photopolymerization-based, materials extrusion-based, sheet lamination-based, binder jetting-based, power bed fusion-based and direct energy deposition-based processes. 3D printing offers unparalleled flexibility and simplicity in the fabrication of highly complex 3D objects. Read More

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http://dx.doi.org/10.3390/polym10060629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403645PMC
June 2018
4 Reads

Advances in dermoepidermal skin substitutes for diabetic foot ulcers.

Curr Vasc Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis. Greece.

Diabetic foot ulcers (DFUs) are one of the major complications of diabetes, representing a leading cause of hospitalisation and non-traumatic lower limb amputations. Multidisciplinary management, patient education, glucose control, debridement, off-loading, infection control, and adequate perfusion are the mainstays of standard care. Despite all these, at least 30% of DFUs fail to heal within 20 weeks. Read More

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http://dx.doi.org/10.2174/1570161117666190408170144DOI Listing
April 2019
5 Reads

Recent Therapeutic Advances and Change in Treatment Paradigm of Patients with Merkel Cell Carcinoma.

Oncologist 2019 Apr 8. Epub 2019 Apr 8.

Medical Oncology Department, University General Hospital of Valencia, Valencia, Spain.

Merkel cell carcinoma (MCC) is a rare, aggressive, primary cutaneous neuroendocrine tumor that typically presents as an indurated nodule on sun-exposed areas of the head and neck in the white population. Major risk factors include immunosuppression, UV light exposure, and advanced age. Up to 80% of MCC are associated with Merkel cell polyomavirus. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0718DOI Listing
April 2019
1 Read

Recent Overviews in Functional Polymer Composites for Biomedical Applications.

Polymers (Basel) 2018 Jul 4;10(7). Epub 2018 Jul 4.

Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, Qatar.

Composite materials are considered as an essential part of our daily life due to their outstanding properties and diverse applications. Polymer composites are a widespread class of composites, characterized by low cost, facile processing methods, and varied applications ranging from daily-use issues to highly complicated electronics and advanced medical combinations. In this review, we focus on the most important fabrication techniques for bioapplied polymer composites such as electrospinning, melt-extrusion, solution mixing, and latex technology, as well as in situ methods. Read More

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http://dx.doi.org/10.3390/polym10070739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403933PMC

Recent Advances in Engineered Stem Cell-Derived Cell Sheets for Tissue Regeneration.

Polymers (Basel) 2019 Jan 26;11(2). Epub 2019 Jan 26.

Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea.

The substantial progress made in the field of stem cell-based therapy has shown its significant potential applications for the regeneration of defective tissues and organs. Although previous studies have yielded promising results, several limitations remain and should be overcome for translating stem cell-based therapies to clinics. As a possible solution to current bottlenecks, cell sheet engineering (CSE) is an efficient scaffold-free method for harvesting intact cell sheets without the use of proteolytic enzymes, and may be able to accelerate the adoption of stem cell-based treatments for damaged tissues and organs regeneration. Read More

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http://dx.doi.org/10.3390/polym11020209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419010PMC
January 2019
2.505 Impact Factor

Pathophysiology of atopic dermatitis.

J Dtsch Dermatol Ges 2019 Apr;17(4):433-440

Department of Dermatology and Allergology, Christine Kühne Center for Allergy Research and Education, Universität of Bonn, Bonn, Germany.

Only few diseases have been studied as extensively and on as many different levels in recent years as atopic dermatitis (AD). One of the reasons why AD is the focus of interest is that it is one of the most common chronic inflammatory skin diseases, affecting up to 30 % of children and 1-10 % of adults. Numerous complex alterations both on the genetic level as well as on the level of innate and adaptive immunity have been identified and form the basis for the characterization of different patient groups and the development of novel diagnostic and therapeutic approaches. Read More

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http://dx.doi.org/10.1111/ddg.13819DOI Listing
April 2019
1 Read

Transcutaneous Delivery of DNA/mRNA for Cancer Therapeutic Vaccination.

J Gene Med 2019 Apr 8:e3089. Epub 2019 Apr 8.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Therapeutic vaccination is a promising strategy in immunotherapy of cancers. It eradicates cancer cells by evoking and strengthening patients' own immune system. Because of the easy access and sophisticated immune networks, the skin becomes an ideal target organ for vaccination. Read More

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http://dx.doi.org/10.1002/jgm.3089DOI Listing

Limitations and Opportunities in Topical Drug Delivery: Interaction between Silica Nanoparticles and Skin Barrier.

Curr Pharm Des 2019 Apr 4. Epub 2019 Apr 4.

Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile. Chile.

The first limiting barrier for the transport in the skin is the stratum corneum; different strategies have been developed to overcome this barrier, including chemical enhancers. However, these penetration enhancers have limitations, including toxic adverse effects. In this context, research into nanomaterials has provided new tools to increase the residence time of drugs by generating a reservoir, increasing the specificity of drugs and reducing their adverse effects, and improving the penetration of drugs that are difficult to formulate. Read More

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http://dx.doi.org/10.2174/1381612825666190404121507DOI Listing

Cannabis allergy: what the clinician needs to know in 2019.

Expert Rev Clin Immunol 2019 Apr 4:1-8. Epub 2019 Apr 4.

a Department of Immunology-Allergology-Rheumatology , Antwerp University Hospital, University of Antwerp , Antwerp , Belgium.

Introduction: Although the use of cannabis dates back millennia, the first description of cannabis allergy is relatively recent (1971). Recent large-scale data show that cannabis allergy can manifest severe and generalized symptoms with extensive cross-reactions. Thus, it is essential to become familiarized with its clinical presentation, diagnostic aids, and adequate therapeutic guidance. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1600403DOI Listing
April 2019
3 Reads

Progress in Developing Decellularized Bioscaffolds for Enhancing Skin Construction.

J Biomed Mater Res A 2019 Apr 3. Epub 2019 Apr 3.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

The skin is the largest organ in the human body, and skin defects are very common. Skin flap transplantation is the best treatment for serious wound defects, and donor site tissues are always sacrificed during this process. Decellularized biomaterials, derived mainly from various nonautologous organs and tissues, have promising applications in tissue engineering and repair of wound defects. Read More

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http://dx.doi.org/10.1002/jbm.a.36688DOI Listing
April 2019
5 Reads

Toward a new generation of smart skins.

Nat Biotechnol 2019 04 2;37(4):382-388. Epub 2019 Apr 2.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Rapid advances in soft electronics, microfabrication technologies, miniaturization and electronic skins are facilitating the development of wearable sensor devices that are highly conformable and intimately associated with human skin. These devices-referred to as 'smart skins'-offer new opportunities in the research study of human biology, in physiological tracking for fitness and wellness applications, and in the examination and treatment of medical conditions. Over the past 12 months, electronic skins have been developed that are self-healing, intrinsically stretchable, designed into an artificial afferent nerve, and even self-powered. Read More

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http://www.nature.com/articles/s41587-019-0079-1
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http://dx.doi.org/10.1038/s41587-019-0079-1DOI Listing
April 2019
10 Reads

The Cutaneous Microbiome: Implications for Dermatology Practice.

J Cutan Med Surg 2019 Apr 2:1203475419839939. Epub 2019 Apr 2.

4 Provincial Laboratory for Public Health (ProvLab), Alberta Public Laboratories, Edmonton, AB, Canada.

The human integument is inhabited by a vast array of microorganisms known collectively as the cutaneous microbiome. As a result of advances in laboratory science, our understanding of the diversity and complexity of the human microbiome is rapidly evolving. In particular, advances in the field of genomics have enabled the study of the cutaneous microbiome with a hitherto unimaginable level of detail, resulting in a maturation of our understanding of cutaneous health and disease. Read More

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http://dx.doi.org/10.1177/1203475419839939DOI Listing
April 2019
2 Reads

In Vitro Assessment of Microbial Barrier Properties of Cyanoacrylate Tissue Adhesives and Pressure-Sensitive Adhesives.

Surg Infect (Larchmt) 2019 Mar 30. Epub 2019 Mar 30.

1 Division of Infectious Diseases, University of Kansas Health System, Kansas City, Kansas.

Background: Despite advances in incision care and surgical dressings, surgical site infections remain a common complication. Post-operative contamination of a surgical site is believed to play a role in many of these infections. Most surgical dressings adhere to the skin with pressure-sensitive adhesives. Read More

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https://www.liebertpub.com/doi/10.1089/sur.2018.280
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http://dx.doi.org/10.1089/sur.2018.280DOI Listing
March 2019
3 Reads

Filtered Mechanosensing Using Snapping Composites with Embedded Mechano-Electrical Transduction.

ACS Nano 2019 Apr 9. Epub 2019 Apr 9.

School of Mechanical Engineering , Purdue University , 585 Purdue Mall , West Lafayette , Indiana 47907 , United States.

Mechanosensing is ubiquitous in natural systems. From the skin ridges of our finger tips to the microscopic ion channels in cells, mechanosensors allow organisms to probe their environment and gather information needed for processing, decision making, and actuation. Despite technological advances in synthetic mechanosensing, it remains challenging to achieve this functionality at the scale of large stiff structures where both the amount of data to sense locally and the diversity of input stresses that the sensors have to withstand require highly tunable systems. Read More

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http://dx.doi.org/10.1021/acsnano.9b01095DOI Listing
April 2019
1 Read
12.881 Impact Factor

Cancer-associated secondary lymphoedema.

Nat Rev Dis Primers 2019 Mar 28;5(1):22. Epub 2019 Mar 28.

Department of Oncology, McGill University, Montreal, Canada.

Lymphoedema is an oedematous condition with a specific and complex tissue biology. In the clinical context of cancer, the pathogenesis of lymphoedema ensues most typically from the modalities employed to stage and treat the cancer (in particular, surgery and radiotherapy). Despite advances in cancer treatment, lifelong lymphoedema (limb swelling and the accompanying chronic inflammatory processes) affects approximately one in seven individuals treated for cancer, although estimates of lymphoedema prevalence following cancer treatment vary widely depending upon the diagnostic criteria used and the duration of follow-up. Read More

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http://dx.doi.org/10.1038/s41572-019-0072-5DOI Listing

Propionibacterium acnes susceptibility to low-level 449 nm blue light photobiomodulation.

Lasers Surg Med 2019 Mar 28. Epub 2019 Mar 28.

The Johnson and Johnson Skin Research Center, Johnson and Johnson Consumer Inc. Skillman, Skillman, New Jersey.

Background And Objective: Recent advances in low-level light devices have opened new treatment options for mild to moderate acne patients. Light therapies have been used to treat a variety of skin conditions over the years but were typically only available as treatments provided by professional clinicians. Clinical application of blue light has proven to be effective for a broader spectral range and at lower fluences than previously utilized. Read More

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http://dx.doi.org/10.1002/lsm.23087DOI Listing

Cochlear Implantation and Rehabilitation.

Adv Exp Med Biol 2019 ;1130:129-144

Key Laboratory of Hearing Medicine of NHFPC, ENT Institute and Otorhinolaryngology Department, Shanghai Engineering Research Centre of Cochlear Implant, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.

Cochlear implant (CI) is currently the only medical treatment available to partially restore hearing to patients with profound-to-severe hearing loss. CI is fundamentally distinct from hearing aid (HA) use, as implants are surgically placed under the skin behind the ear where they bypass the normal sound-conducting mechanism, convert sound signals into electrical stimulation, and directly stimulate the residual auditory nerves. In recent years, CI has evolved into one of the most profound advances in modern medicine and provided hearing to more than 320,000 deaf patients. Read More

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http://dx.doi.org/10.1007/978-981-13-6123-4_8DOI Listing
January 2019

Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system.

Lab Chip 2019 Mar 26. Epub 2019 Mar 26.

Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA. and Center for Bio-Integrated Electronics, Simpson Querry Institute for BioNanotechnology, Northwestern University, Evanston, IL 60208, USA.

The rich range of biomarkers in sweat and the ability to collect sweat in a non-invasive manner create interest in the use of this biofluid for assessments of health and physiological status, with potential applications that range from sports and fitness to clinical medicine. This paper introduces two important advances in recently reported classes of soft, skin-interfaced microfluidic systems for sweat capture and analysis: (1) a simple, broadly applicable means for collection of sweat that bypasses requirements for physical/mental exertion or pharmacological stimulation and (2) a set of enzymatic chemistries and colorimetric readout approaches for determining the concentrations of creatinine and urea in sweat, throughout ranges that are physiologically relevant. The results allow for routine, non-pharmacological capture of sweat for patient populations, such as infants and the elderly, that cannot be expected to sweat through exercise, and they create potential opportunities in the use of sweat for kidney disease screening/monitoring. Read More

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http://dx.doi.org/10.1039/c9lc00103dDOI Listing
March 2019
2 Reads

Research Techniques Made Simple: Profiling the Skin Microbiota.

J Invest Dermatol 2019 Apr;139(4):747-752.e1

Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA; Department of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

Skin is colonized by microbial communities (microbiota) that participate in immune homeostasis, development and maintenance of barrier function, and protection from pathogens. The past decade has been marked by an increased interest in the skin microbiota and its role in cutaneous health and disease, in part due to advances in next-generation sequencing platforms that enable high-throughput, culture-independent detection of bacteria, fungi, and viruses. Various approaches, including bacterial 16S ribosomal RNA gene sequencing and metagenomic shotgun sequencing, have been applied to profile microbial communities colonizing healthy skin and diseased skin including atopic dermatitis, psoriasis, and acne, among others. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.024DOI Listing

Lupus nephritis: A historical appraisal of how a skin lesion became a kidney disease
.

Clin Nephrol 2019 Mar 22. Epub 2019 Mar 22.

"Lupus nephritis", a serious complication of systemic lupus erythematosus (SLE), is an entity of recent vintage. The term "lupus", derived from Latin for wolf, was introduced in the Middle Ages to denote nondescript erosive skin lesions which resembled wolf bites that were known theretofore by their Greek name of "", used in the Hippocratic Corpus for the spread of the lesions like a crawling snake. The specific dermatologic features of lupus were characterized as an "erythematous" butterfly rash in 1828 and dubbed "lupus erythematosus" in 1850. Read More

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http://dx.doi.org/10.5414/CN109675DOI Listing
March 2019
3 Reads

Advances in the clinical and mechanism research of pollen induced seasonal allergic asthma.

Am J Clin Exp Immunol 2019 15;8(1):1-8. Epub 2019 Feb 15.

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730, P.R. China.

Seasonal allergic asthma prevalence has been increasing over the last decades and is one of global health concerns now. Pollen is one of the main reasons to cause seasonal allergic asthma and influenced by multiple risk factors. Thunderstorm-related asthma is a typical type of seasonal allergic asthma that thunderstorms occurring can induce severe asthma attacks during pollen season. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420698PMC
February 2019
1 Read

Recent advances on the roles of epidermal growth factor receptor in psoriasis.

Am J Transl Res 2019 15;11(2):520-528. Epub 2019 Feb 15.

Department of Dermatology, Nanfang Hospital, Southern Medical University Guangzhou 510515, Guangdong, China.

Epidermal growth factor receptor (EGFR) is a well-characterized receptor tyrosine kinase that involved in many vital activities in cell development, such as cellular homeostasis, proliferation, division, differentiation and apoptosis. Natural activation of EGFR and the concomitant downstream signaling pathways regulation are substantial to maintain normal cellular functions. In recent studies, EGFR was demonstrated to be a fundamental modulator in the control of skin inflammatory responses. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413281PMC
February 2019

[Advances in the research of sensory nerve regeneration in tissue engineering skin].

Zhonghua Shao Shang Za Zhi 2019 Mar;35(3):237-240

Department of Burns, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

Severe skin damage not only causes a mass of tissue defect, but also leads to the loss of various sensory functions. Tissue engineering skin provides a new way for high-quality wound repair, while there are still many problems in the recovery of sensory function, such as abnormality or loss of sensation of pain, touch, and temperature. Therefore, when tissue engineering skin is used to promote wound healing, regeneration and functional recovery of sensory nerve have attracted more and more attention. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.03.016DOI Listing

Applied Bioengineering in Tissue Reconstruction, Replacement, and Regeneration.

Tissue Eng Part B Rev 2019 Mar 21. Epub 2019 Mar 21.

Vanderbilt University Medical Center, 12328, Plastic Surgery and Biomedical Engineering, Nashville, Tennessee, United States ;

To this day, tissue reconstruction and replacement to address extensive tissue defects due to trauma, tumor resection, genetic and/or chronic diseases, or excessive debridement presents a major clinical challenge. Traditional reconstructive techniques most commonly utilize autologous tissue. Undoubtedly, autologous composite tissue transfers or "flaps", skin grafts, as well as the harvesting of bone and/or cartilage have substantially improved the health, functional, and aesthetic outcomes of millions of patients. Read More

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http://dx.doi.org/10.1089/ten.TEB.2018.0325DOI Listing
March 2019
1 Read

Detecting changes in facial temperature induced by a sudden auditory stimulus based on deep learning-assisted face tracking.

Sci Rep 2019 Mar 18;9(1):4729. Epub 2019 Mar 18.

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Thermal Imaging (Infrared-Imaging-IRI) is a promising new technique for psychophysiological research and application. Unlike traditional physiological measures (like skin conductance and heart rate), it is uniquely contact-free, substantially enhancing its ecological validity. Investigating facial regions and subsequent reliable signal extraction from IRI data is challenging due to head motion artefacts. Read More

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http://www.nature.com/articles/s41598-019-41172-7
Publisher Site
http://dx.doi.org/10.1038/s41598-019-41172-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426955PMC
March 2019
3 Reads

Recent advances of collagen-based biomaterials: Multi-hierarchical structure, modification and biomedical applications.

Mater Sci Eng C Mater Biol Appl 2019 Jun 19;99:1509-1522. Epub 2019 Feb 19.

College of Bioresources and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China. Electronic address:

Collagen is the most abundant structural protein of connective tissues including skin, tendon, bone and cartilage in mammals. The complicated biosynthesis of nature collagen in vivo, involving numerous intracellular and extracellular steps, causes it to have a multi-hierarchical fibrous architecture. The bioactivity of collagen is mostly depended on its tertiary structure or above. Read More

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http://dx.doi.org/10.1016/j.msec.2019.02.070DOI Listing

Peripheral Neuropathy and the Insensate Foot: More Than Diabetes.

Adv Skin Wound Care 2019 Apr;32(4):149

R. Gary Sibbald, MD, MEd, DSc (Hons), FRCPC (Med Derm), FAAD, MAPWCA, JM, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Professor, Medicine and Public Health, University of Toronto, Toronto, Ontario, Canada; Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana Faculty of Public Health, University of Toronto; Investigator, Institute for Better Health, Trillium Health Partners; Project Lead, ECHO Ontario, Skin & Wound Care; and President (2008-2012), World Union of Wound Healing Societies. Elizabeth A. Ayello, PhD, RN, CWON, ETN, MAPWCA, FAAN is the co-Editor-in-Chief of Advances in Skin & Wound Care; Faculty, Excelsior College School of Nursing, Albany, New York; Founder and co-Course Director, WoundPedia Manila; President, World Council of Enterostomal Therapists; President, Ayello Harris & Associates, Inc, Copake, New York; and President (1999), National Pressure Ulcer Advisory Panel.

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http://dx.doi.org/10.1097/01.ASW.0000554390.18232.bdDOI Listing
April 2019
2 Reads

IL33: Roles in Allergic Inflammation and Therapeutic Perspectives.

Front Immunol 2019 4;10:364. Epub 2019 Mar 4.

State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

Interleukin (IL)-33 belongs to IL-1 cytokine family which is constitutively produced from the structural and lining cells including fibroblasts, endothelial cells, and epithelial cells of skin, gastrointestinal tract, and lungs that are exposed to the environment. Different from most cytokines that are actively secreted from cells, nuclear cytokine IL-33 is passively released during cell necrosis or when tissues are damaged, suggesting that it may function as an alarmin that alerts the immune system after endothelial or epithelial cell damage during infection, physical stress, or trauma. IL-33 plays important roles in type-2 innate immunity via activation of allergic inflammation-related eosinophils, basophils, mast cells, macrophages, and group 2 innate lymphoid cells (ILC2s) through its receptor ST2. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409346PMC
March 2019
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Seed and soil? - Pharyngeal Merkel cell carcinoma after radiotherapy for laryngeal squamous cell carcinoma.

Am J Otolaryngol 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, 21151 Pomerantz Family Pavilion, 200 Hawkins Drive, 52240, Iowa City, IA, USA.

Merkel cell carcinoma (MCC) is a neuroendocrine cutaneous malignancy that may present as metastatic disease without a known primary site but, most commonly originates in the sun-exposed skin of the head, neck, and extremities. We present a 66-year-old male treated with chemo-radiation for T3N2cM0 laryngeal squamous cell carcinoma (SCCa) six years before he was diagnosed with MCC isolated to the radiated laryngopharynx. Mucosal MCC is rare and radiation-induced MCC has been hypothesized to occur in previously radiated tissue but, never before to the laryngopharynx. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.03.005DOI Listing
March 2019
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Skin-Mountable Biosensors and Therapeutics: A Review.

Annu Rev Biomed Eng 2019 Mar 18. Epub 2019 Mar 18.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA; email:

Miniaturization of electronic components and advances in flexible and stretchable materials have stimulated the development of wearable health care systems that can reflect monitor personal health status by health care professionals. New skin-mountable devices that offer seamless contact onto the human skin, even under large deformations by natural motions of the wearer, provide a route for both high-fidelity monitoring and patient-controlled therapy. This article provides an overview of several important aspects of skin-mountable devices and their applications in many medical settings and clinical practices. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052315DOI Listing

Upgrading prevascularization in tissue engineering: A review of strategies for promoting highly organized microvascular network formation.

Acta Biomater 2019 Mar 13. Epub 2019 Mar 13.

Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, United States. Electronic address:

Functional and perfusable vascular network formation is critical to ensure the long-term survival and functionality of engineered tissues after their transplantation. Although several vascularization strategies have been reviewed in past, the significance of microvessel organization in three-dimensional (3D) scaffolds has been largely ignored. Advances in high-resolution microscopy and image processing have revealed that the majority of tissues including cardiac, skeletal muscle, bone, and skin contain highly organized microvessels that orient themselves to align with tissue architecture for optimum molecular exchange and functional performance. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.016DOI Listing
March 2019
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Host-microbial Dialogues in Atopic Dermatitis.

Int Immunol 2019 Mar 16. Epub 2019 Mar 16.

Cutaneous Leukocyte Biology Section, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10 Room 12N240B, 10 Center Drive, Bethesda, MD 20892.

Recent advances in sequencing technologies have revealed the diversity of microbes that reside on skin surface which has enhanced our understanding on skin as an ecosystem, wherein the epidermis, immune cells and the microbiota engage in active dialogues that maintain barrier integrity and functional immunity. This mutual dialogue is altered in atopic dermatitis (AD), in which impaired epidermal barrier, the skin microbial flora and aberrant immunity can form a vicious cycle that leads to clinical manifestation as eczematous dermatitis. Microbiome studies have revealed altered microbial landscape in AD and genetic studies have identified genes that underlie barrier impairment and immune dysregulation. Read More

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http://dx.doi.org/10.1093/intimm/dxz026DOI Listing
March 2019
2 Reads

Plant Allergen-Induced Contact Dermatitis.

Planta Med 2019 Mar 15. Epub 2019 Mar 15.

Allergy Research Group, Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Although manifold beneficial effects of plant compounds for the treatment of skin disorders are known, cutaneous exposure to plants can also result in various types of incompatibility reactions such as contact dermatitis. In this mini-review, we briefly describe the different clinical forms of contact dermatitis (photoinduced, irritative, and allergic form) and highlight recent publications in the field of contact dermatitis. Major topics are recent recommendations regarding testing for plant contact dermatitis, advances in understanding the immunological mechanisms of plant contact dermatitis, and case reports for plant contact dermatitis. Read More

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http://dx.doi.org/10.1055/a-0873-1494DOI Listing
March 2019
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A somatic missense mutation in GNAQ causes capillary malformation.

Curr Opin Hematol 2019 May;26(3):179-184

Department of Surgery, Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Capillary malformations, the most common type of vascular malformation, are caused by a somatic mosaic mutation in GNAQ, which encodes the Gαq subunit of heterotrimeric G-proteins. How the single amino acid change - predicted to activate Gαq - causes capillary malformations is not known but recent advances are helping to unravel the mechanisms.

Recent Findings: The GNAQ R183Q mutation is present not only in endothelial cells isolated from skin and brain capillary malformations but also in brain tissue underlying the capillary malformation, raising questions about the origin of capillary malformation-causing cells. Read More

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http://dx.doi.org/10.1097/MOH.0000000000000500DOI Listing

Smart Patterned Surface with Dynamic Wrinkles.

Acc Chem Res 2019 Apr 14;52(4):1025-1035. Epub 2019 Mar 14.

School of Chemistry & Chemical Engineering, State Key Laboratory for Metal Matrix Composite Materials , Shanghai Jiao Tong University , Shanghai 200240 , People's Republic of China.

Patterned surfaces are fundamentally important to physics, chemistry, materials, and biology science, endowing significant functions and thus bearing broad and fantastic applications whether in natural or man-made events. Among the various methods for patterning surfaces, wrinkling or buckling offers a powerful alternative to prepare surface patterns because of its spontaneous nature, versatility, easy preparation in large-scale, and capability to be responsive to various stimuli. In particular, patterned surfaces with dynamic wrinkles can tailor the encoded surface properties on demand and can provide a promising alternative for smart surfaces, which has potential for wide applications in enhanced and tunable optical or photoelectric devices, responsive microstructures, switchable wettability, smart adhesion and friction, and so on. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00623DOI Listing

Assessing a small field of view hybrid gamma camera for perioperative iodine-125 seed localisation.

Br J Radiol 2019 Mar 13:20190020. Epub 2019 Mar 13.

1 Radiological Sciences and Precision Imaging Beacon, School of Medicine, University of Nottingham , UK.

Objectives:: To examine the imaging capability of a novel small field of view hybrid γ camera (HGC) using I seeds prior to surgical use.

Methods:: The imaging performance of the camera system was assessed quantitatively and qualitatively at different source depths, source to collimator distances (SCD), activity levels, acquisition times and source separations, utilising bespoke phantoms.

Results:: The system sensitivity and spatial resolution of the HGC for I were 0. Read More

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http://dx.doi.org/10.1259/bjr.20190020DOI Listing
March 2019
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Wearable Electrochemical Alcohol Biosensors.

Curr Opin Electrochem 2018 Aug 23;10:126-135. Epub 2018 May 23.

Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USA.

The rapid development of wearable sensing platforms in recent years has led to an array of viable monitoring applications for various target analytes. As a significant biomarker with high impact in diverse areas, the reliable on-body detection and continuous monitoring of alcohol has become a focus of many such systems. Currently, several commercial sensing platforms are available that are capable of transdermal monitoring of alcohol consumption using insensible sweat. Read More

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http://dx.doi.org/10.1016/j.coelec.2018.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407881PMC