2,763 results match your criteria Advances In Production Engineering & Management[Journal]


Designing complex architectured materials with generative adversarial networks.

Sci Adv 2020 Apr 24;6(17):eaaz4169. Epub 2020 Apr 24.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Architectured materials on length scales from nanometers to meters are desirable for diverse applications. Recent advances in additive manufacturing have made mass production of complex architectured materials technologically and economically feasible. Existing architecture design approaches such as bioinspiration, Edisonian, and optimization, however, generally rely on experienced designers' prior knowledge, limiting broad applications of architectured materials. Read More

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http://dx.doi.org/10.1126/sciadv.aaz4169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182413PMC

In vitro-derived platelets: the challenges we will have to face to assess quality and safety.

Platelets 2020 Jun 2:1-7. Epub 2020 Jun 2.

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge , Cambridge, UK.

Platelet transfusions are given to patients in hospital who have a low blood platelet count (thrombocytopenia) either because of major bleeding (following trauma or surgery) or because the bone marrow production of platelets is impaired often due to chemotherapy, infiltration with malignant cells, fibrosis or genetic disorders. We are currently entirely reliant on blood donors as a source of platelets in transfusion medicine. However, the demand for platelets continues to rise, driven by an aging population, advances in medical procedures and ever more aggressive cancer therapies, while the supply of blood donors continues to remain static. Read More

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http://dx.doi.org/10.1080/09537104.2020.1769051DOI Listing

Engineering Clostridium ljungdahlii as the gas-fermenting cell factory for the production of biofuels and biochemicals.

Curr Opin Chem Biol 2020 May 29;59:54-61. Epub 2020 May 29.

Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China. Electronic address:

Clostridium ljungdahlii is a representative autotrophic gas-fermenting acetogen capable of converting CO and CO into biomass and multiple metabolites. The carbon fixation and conversion based on C. ljungdahlii have great potential for the sustainable production of bulk biochemicals and biofuels using industrial syngas and waste gases. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.04.010DOI Listing

Towards sustainable environmental quality: Priority research questions for Asia.

Environ Toxicol Chem 2020 May 30. Epub 2020 May 30.

School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, China.

Environmental and human health challenges are pronounced in Asia, an exceptionally diverse and complex region where global megatrends are extensive and numerous stresses to environmental quality exist. Identifying priorities necessary to engage grand challenges can be facilitated through horizon scanning exercises, and to this end we identified and examined 23 priority research questions needed to advance toward more sustainable environmental quality in Asia, as part of the Global Horizon Scanning Project. Advances in environmental toxicology, environmental chemistry, biological monitoring and risk assessment methodologies are necessary to address adverse impact of environmental stressors on ecosystem services and biodiversity, for which Asia is home to numerous biodiversity hotspots. Read More

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http://dx.doi.org/10.1002/etc.4788DOI Listing

Recent advances and perspectives of ultrasound assisted membrane food processing.

Food Res Int 2020 Jul 16;133:109163. Epub 2020 Mar 16.

Centro Regional de Estudios en Alimentos Saludables, CONICYT-REGIONAL GORE, Región de Valparaíso R12C1001, Chile. Electronic address:

Power ultrasound (US) transmits substantial amounts of small mechanical movements serving for particle detaching in membrane filtrations. This topic has been reviewed in recent years mainly focused on the mechanisms by which the flux is improved under specific processing conditions. US also been shown to improve food quality by changing physical properties and modifying the activity of enzymes and microorganisms. Read More

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http://dx.doi.org/10.1016/j.foodres.2020.109163DOI Listing

Recent advances in production and extraction of bacterial lipids for biofuel production.

Sci Total Environ 2020 May 19;734:139420. Epub 2020 May 19.

Zachry Department of Civil and Environmental Engineering, Texas A&M University, College Station, TX 77843-3136, USA. Electronic address:

Lipid-based biofuel is a clean and renewable energy that has been recognized as a promising replacement for petroleum-based fuels. Lipid-based biofuel can be made from three different types of intracellular biolipids; triacylglycerols (TAGs), wax esters (WEs), and polyhydroxybutyrate (PHB). Among many lipid-producing prokaryotes and eukaryotes, biolipids from prokaryotes have been recently highlighted due to simple cultivation of lipid-producing prokaryotes and their ability to accumulate high biolipid contents. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139420DOI Listing

Rhizosphere microbiome: Engineering bacterial competitiveness for enhancing crop production.

J Adv Res 2020 Jul 29;24:337-352. Epub 2020 Apr 29.

Metagenomics and Secretomics Research Laboratory, Department of Botany, Dr. Harisingh Gour University (A Central University), Sagar 470003, M.P., India.

Plants in nature are constantly exposed to a variety of abiotic and biotic stresses which limits their growth and production. Enhancing crop yield and production to feed exponentially growing global population in a sustainable manner by reduced chemical fertilization and agrochemicals will be a big challenge. Recently, the targeted application of beneficial plant microbiome and their cocktails to counteract abiotic and biotic stress is gaining momentum and becomes an exciting frontier of research. Read More

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http://dx.doi.org/10.1016/j.jare.2020.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240055PMC

Towards the Microbial Production of Plant-Derived Anticancer Drugs.

Trends Cancer 2020 Jun 5;6(6):444-448. Epub 2020 Mar 5.

Groupe d'Etude des Interactions Hôte-Pathogène, GEIHP, EA3142, Univ Angers, SFR 4208 ICAT, Angers, France.

Many of the plant-derived compounds used in chemotherapies are currently produced by semisynthesis, which results in limited supplies at exorbitant market prices. However, the synthetic biology era, which began ca 15 years ago, has progressively yielded encouraging advances by using engineered microbes for the practical production of cheaper plant anticancer drugs. Read More

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http://dx.doi.org/10.1016/j.trecan.2020.02.004DOI Listing

Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease.

Exp Mol Med 2020 May 26. Epub 2020 May 26.

Laboratory of Liver Research, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

Alcoholic liver disease (ALD) is one of the fastest-growing concerns worldwide. In addition to bacterial endotoxins in the portal circulation, recent lines of evidence have suggested that sterile inflammation caused by a wide range of stimuli induces alcoholic liver injury, in which damage-associated molecular patterns (DAMPs) play critical roles in inducing de novo lipogenesis and inflammation through the activation of cellular pattern recognition receptors such as Toll-like receptors in non-parenchymal cells. Interestingly, alcohol-mediated metabolic, neurological, and immune stresses stimulate the generation of DAMPs that are released not only in the liver, but also in other organs, such as adipose tissue, intestine, and bone marrow. Read More

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http://dx.doi.org/10.1038/s12276-020-0438-5DOI Listing

A 96-well high-throughput, rapid-screening platform of extracellular electron transfer in microbial fuel cells.

Biosens Bioelectron 2020 Aug 8;162:112259. Epub 2020 May 8.

Bioelectronics & Microsystems Laboratory, Department of Electrical & Computer Engineering, State University of New York-Binghamton, Binghamton, NY, 13902-6000, USA. Electronic address:

Microbial extracellular electron transfer (EET) stimulates a plethora of intellectual concepts leading to potential applications that offer environmentally sustainable advances in the fields of biofuels, wastewater treatment, bioremediation, desalination, and biosensing. Despite its vast potential and remarkable research efforts to date, bacterial electrogenicity is arguably the most underdeveloped technology used to confront the aforementioned challenges. Severe limitations are placed in the intrinsic energy and electron transfer processes of naturally occurring microorganisms. Read More

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http://dx.doi.org/10.1016/j.bios.2020.112259DOI Listing

Precision genome editing in plants: state-of-the-art in CRISPR/Cas9-based genome engineering.

BMC Plant Biol 2020 May 25;20(1):234. Epub 2020 May 25.

Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.

Traditionally, generation of new plants with improved or desirable features has relied on laborious and time-consuming breeding techniques. Genome-editing technologies have led to a new era of genome engineering, enabling an effective, precise, and rapid engineering of the plant genomes. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) has emerged as a new genome-editing tool, extensively applied in various organisms, including plants. Read More

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http://dx.doi.org/10.1186/s12870-020-02385-5DOI Listing

Downstream processing technologies in the biocatalytic production of oligosaccharides.

Biotechnol Adv 2020 May 22:107568. Epub 2020 May 22.

Austrian Centre of Industrial Biotechnology (acib), Krenngasse 37, 8010 Graz, Austria; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Petersgasse 12, 8010 Graz, Austria. Electronic address:

Oligosaccharides are important ingredients for food and feed products. There has therefore been much interest in the development of biocatalytic processes for their production. Irrespective of the oligosaccharide manufacturing route, that is, bottom-up synthesis or controlled depolymerization of a polysaccharide, isolating the product from the reaction mixture usually presents a considerable challenge. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2020.107568DOI Listing

Evolution in crop improvement approaches and future prospects of molecular markers to CRISPR/Cas9 system.

Gene 2020 May 22;753:144795. Epub 2020 May 22.

Department of Biotechnology, School of Basic and Applied Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, Uttarakhand, India. Electronic address:

The advent of genetic selection and genome modification method assure about a real novel reformation in biotechnology and genetic engineering. With the extensive capabilities of molecular markers of them being stable, cost-effective and easy to use, they ultimately become a potent tool for variety of applications such a gene targeting, selection, editing, functional genomics; mainly for the improvisation of commercially important crops. Three main benefits of molecular marker in the field of agriculture and crop improvement programmes first, reduction of the duration of breeding programmes, second, they allow creation of new genetic variation and genetic diversity of plants and third most promising benefit is help in production of engineered plant for disease resistance, or resistance from pathogen and herbicides. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144795DOI Listing

Application of Amniotic Stem Cells on an Acellular Dermal Matrix Scaffold in a Burned Patient: A Case Report.

Transplant Proc 2020 May 19. Epub 2020 May 19.

Dr Stanislaw Sakiel Centre for Burns Treatment, Siemianowice Śląskie, Poland.

Background: Advances in science have allowed newly created medicinal products based on gene therapy, somatic cell therapy, and tissue engineering to be used in the treatment of human diseases. December 2008 legislation aims to ensure they are both safe for patients and available throughout the European Union. Amniotic stem cells are designated by the European Medicines Agency Committee for Advanced Therapies as an advanced therapy medicinal product; therefore, production must be in accordance with Regulation (EC) No. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.110DOI Listing

Flow with variable pulse frequencies accelerates vascular recellularization and remodeling of a human bioscaffold.

J Biomed Mater Res A 2020 May 22. Epub 2020 May 22.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.

Despite significant advances in vascular tissue engineering, the ideal graft has not yet been developed and autologous vessels remain the gold standard substitutes for small diameter bypass procedures. Here, we explore the use of a flow field with variable pulse frequencies over the regeneration of an ex vivo-derived human scaffold as vascular graft. Briefly, human umbilical veins were decellularized and used as scaffold for cellular repopulation with human smooth muscle cells (SMC) and endothelial cells (EC). Read More

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http://dx.doi.org/10.1002/jbm.a.37009DOI Listing

Using Post-graphene 2D Materials to Detect and Remove Pesticides: Recent Advances and Future Recommendations.

Bull Environ Contam Toxicol 2020 May 20. Epub 2020 May 20.

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211800, People's Republic of China.

Detection and removal of pesticides have become increasingly imperative as the widespread production and use of pesticides severely contaminate soil and groundwater and cause serious problems to non-target species such as human and animals. Recently, new two-dimensional materials beyond graphene (e.g. Read More

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http://dx.doi.org/10.1007/s00128-020-02868-zDOI Listing

Recent Advances in Metabolically Engineered Microorganisms for the Production of Aromatic Chemicals Derived From Aromatic Amino Acids.

Front Bioeng Biotechnol 2020 5;8:407. Epub 2020 May 5.

Guangdong Province Key Laboratory of Improved Variety Reproduction in Aquatic Economic Animals, Biomedical Center, School of Life Sciences, Institute of Synthetic Biology, Sun Yat-sen University, Guangzhou, China.

Aromatic compounds derived from aromatic amino acids are an important class of diverse chemicals with a wide range of industrial and commercial applications. They are currently produced via petrochemical processes, which are not sustainable and eco-friendly. In the past decades, significant progress has been made in the construction of microbial cell factories capable of effectively converting renewable carbon sources into value-added aromatics. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214760PMC

Recent Advances of SnO-Based Sensors for Detecting Volatile Organic Compounds.

Front Chem 2020 5;8:321. Epub 2020 May 5.

College of Engineering and Technology, Southwest University, Chongqing, China.

SnO based sensors has received extensive attention in the field of toxic gas detection due to their excellent performances with high sensitivity, fast response, long-term stability. Volatile organic compounds (VOCs), originate from industrial production, fuel burning, detergent, adhesives, and painting, are poisonous gases with significant effects on air quality and human health. This mini-review focuses on significant improvement of SnO based sensors in VOCs detection in recent years. Read More

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http://dx.doi.org/10.3389/fchem.2020.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214870PMC

Covalent organic framework photocatalysts: structures and applications.

Chem Soc Rev 2020 May 18. Epub 2020 May 18.

Department of Chemical Engineering, University College London, Torrington Place, London, WC1E7JE, UK.

In the light of increasing energy demand and environmental pollution, it is urgently required to find a clean and renewable energy source. In these years, photocatalysis that uses solar energy for either fuel production, such as hydrogen evolution and hydrocarbon production, or environmental pollutant degradation, has shown great potential to achieve this goal. Among the various photocatalysts, covalent organic frameworks (COFs) are very attractive due to their excellent structural regularity, robust framework, inherent porosity and good activity. Read More

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http://dx.doi.org/10.1039/d0cs00278jDOI Listing

Application of Hairy Root Culture for Bioactive Compounds Production in Medicinal Plants.

Curr Pharm Biotechnol 2020 May 16. Epub 2020 May 16.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No.151 Malianwa North Road, Haidian District, Beijing 100193. China.

Medicinal plants are rich sources of natural bioactive compounds used to treat many diseases. With the development of the health industry, the market demands for Chinese medicine have increased rapidly in recent years. However, over-utilization of herbal plants would cause serious ecological problems. Read More

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http://dx.doi.org/10.2174/1389201021666200516155146DOI Listing

Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing.

Biotechnol Adv 2020 May 13:107552. Epub 2020 May 13.

Cell Technology Group, National Institute for Bioprocessing, Research and Training (NIBRT), Fosters Avenue, Mount Merrion, Blackrock, Dublin A94 X099, Ireland. Electronic address:

The manufacturing of recombinant protein is traditionally undertaken in mammalian cell culture. Today, speed, cost and safety are the primary considerations for process improvements in both upstream and downstream manufacturing. Leaders in the biopharmaceutical industry are striving for continuous improvements to increase throughput, lower costs and produce safer more efficacious drugs. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2020.107552DOI Listing

Industrial Use of Cell Wall Degrading Enzymes: The Fine Line Between Production Strategy and Economic Feasibility.

Front Bioeng Biotechnol 2020 29;8:356. Epub 2020 Apr 29.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Cell Wall Degrading Enzymes (CWDEs) are a heterogeneous group of enzymes including glycosyl-hydrolases, oxidoreductases, lyases, and esterases. Microbes with degrading activities toward plant cell wall polysaccharides are the most relevant source of CWDEs for industrial applications. These organisms secrete a wide array of CWDEs in amounts strictly necessary for their own sustenance, nonetheless the production of CWDEs from wild type microbes can be increased at large-scale by using optimized fermentation strategies. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200985PMC

Phenotypic and molecular insights into heat tolerance of formulated cells as active ingredients of fungal insecticides.

Appl Microbiol Biotechnol 2020 May 13. Epub 2020 May 13.

Institute of Microbiology, College of Life Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.

Formulated conidia of insect-pathogenic fungi, such as Beauveria and Metarhizium, serve as the active ingredients of fungal insecticides but are highly sensitive to persistent high temperatures (32-35 °C) that can be beyond their upper thermal limits especially in tropical areas and during summer months. Fungal heat tolerance and inter- or intra-specific variability are critical factors and limitations to field applications of fungal pesticides during seasons favoring outbreaks of pest populations. The past decades have witnessed tremendous advances in improving fungal pesticides through selection of heat-tolerant strains from natural isolates, improvements and innovations in terms of solid-state fermentation technologies for the production of more heat-tolerant conidia, and the use of genetic engineering of candidate strains for enhancing heat tolerance. Read More

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http://dx.doi.org/10.1007/s00253-020-10659-zDOI Listing

Short-chain fatty acids recovery from sewage sludge via acidogenic fermentation as a carbon source for denitrification: A review.

Bioresour Technol 2020 Apr 25;311:123446. Epub 2020 Apr 25.

School of Environmental and Chemical Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China. Electronic address:

Wastewater treatment plants face the problem of a shortage of carbon source for denitrification. Acidogenic fermentation is an effective method for recovering short-chain fatty acids (SCFAs) as a carbon source from sewage sludge. Herein, the most recent advances in SCFAs production from primary sludge and waste activated sludge are systematically summarised and discussed. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123446DOI Listing

Comment on "On the calculation of lake metabolic rates: Diel O and O technique" by Peeters et al. [Water Res. 165 2019, 114990].

Water Res 2020 May 8:115772. Epub 2020 May 8.

Groupe de recherche interuniversitaire en limnologie, Département des sciences biologiques, Université du Québec à Montréal, Montréal, QC, Canada.

Quantifying metabolic rates in lakes and other aquatic ecosystems is a complex task, as methods are continually evolving and are not currently standardized. Recently, Peeters et al. presented a valuable simulated dataset that advances the field by comparing the strengths and limitations of individual and combined metabolic techniques. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115772DOI Listing

Increased soil release of greenhouse gases shrinks terrestrial carbon uptake enhancement under warming.

Glob Chang Biol 2020 May 13. Epub 2020 May 13.

Jiangsu Key Laboratory of Low Carbon Agriculture and GHGs Mitigation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, China.

Warming can accelerate the decomposition of soil organic matter and stimulate the release of soil greenhouse gases (GHGs), but to what extent soil release of methane (CH ) and nitrous oxide (N O) may contribute to soil C loss for driving climate change under warming remains unresolved. By synthesizing 1,845 measurements from 164 peer-reviewed publications, we show that around 1.5°C (1. Read More

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http://dx.doi.org/10.1111/gcb.15156DOI Listing
May 2020
8.044 Impact Factor

Microbial astaxanthin biosynthesis: recent achievements, challenges, and commercialization outlook.

Appl Microbiol Biotechnol 2020 May 13. Epub 2020 May 13.

Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Proteos level 4, Singapore, 138673, Singapore.

Astaxanthin is a natural pigment, known for its strong antioxidant activity and numerous health benefits to human and animals. Its antioxidant activity is known to be substantially greater than β-carotene and about a thousand times more effective than vitamin E. The potential health benefits have generated a growing commercial interest, and the escalating demand has prompted the exploration of alternative supply chain. Read More

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http://dx.doi.org/10.1007/s00253-020-10648-2DOI Listing

Up-Flow Anaerobic Sludge Blanket (UASB) Technology for Energy Recovery: A Review on State-of-the-Art and Recent Technological Advances.

Bioengineering (Basel) 2020 May 10;7(2). Epub 2020 May 10.

Department Polytechnic of Engineering and Architecture (DPIA), University of Udine, Via del Cotonificio 108, 33100 Udine, Italy.

Up-flow anaerobic sludge blanket (UASB) reactor belongs to high-rate systems, able to perform anaerobic reaction at reduced hydraulic retention time, if compared to traditional digesters. In this review, the most recent advances in UASB reactor applications are critically summarized and discussed, with outline on the most critical aspects for further possible future developments. Beside traditional anaerobic treatment of soluble and biodegradable substrates, research is actually focusing on the treatment of refractory and slowly degradable matrices, thanks to an improved understanding of microbial community composition and reactor hydrodynamics, together with utilization of powerful modeling tools. Read More

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http://dx.doi.org/10.3390/bioengineering7020043DOI Listing

Recent advances in catalytic co-pyrolysis of biomass and plastic waste for the production of petroleum-like hydrocarbons.

Bioresour Technol 2020 Aug 4;310:123473. Epub 2020 May 4.

School of Environmental Engineering, University of Seoul, Seoul 02504, Republic of Korea. Electronic address:

The global economy is threatened by the depletion of fossil resources and fluctuations in fossil fuel prices, and thus it is necessary to exploit sustainable energy sources. Carbon-neutral fuels including bio-oil obtained from biomass pyrolysis can act as alternatives to fossil fuels. Co-pyrolysis of lignocellulosic biomass and plastic is efficient to upgrade the quality of bio-oil because plastic facilitates deoxygenation. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123473DOI Listing

Anaerobic and hydrogenogenic carbon monoxide-oxidizing prokaryotes: Versatile microbial conversion of a toxic gas into an available energy.

Adv Appl Microbiol 2020 2;110:99-148. Epub 2020 Jan 2.

Laboratory of Marine Microbiology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. Electronic address:

Carbon monoxide (CO) is a gas that is toxic to various organisms including humans and even microbes; however, it has low redox potential, which can fuel certain microbes, namely, CO oxidizers. Hydrogenogenic CO oxidizers utilize an energy conservation system via a CO dehydrogenase/energy-converting hydrogenase complex to produce hydrogen gas, a zero emission fuel, by CO oxidation coupled with proton reduction. Biochemical and molecular biological studies using a few model organisms have revealed their enzymatic reactions and transcriptional response mechanisms using CO. Read More

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http://dx.doi.org/10.1016/bs.aambs.2019.12.001DOI Listing
January 2020

RNA-Seq transcriptomic analyses of Antrodia camphorata to determine antroquinonol and antrodin C biosynthetic mechanisms in the in situ extractive fermentation.

J Sci Food Agric 2020 May 6. Epub 2020 May 6.

Shanghai Engineering Research Center of Food Microbiology, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.

Background: In situ extractive fermentation (ISEF) is an important technique for improving metabolite productivity. The different extractants can induce the synthesis of different bioactive metabolites of Antrodia camphorata during ISEF. However, a lack of research on the molecular genetics of A. Read More

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http://dx.doi.org/10.1002/jsfa.10467DOI Listing

Omics for Bioprospecting and Drug Discovery from Bacteria and Microalgae.

Antibiotics (Basel) 2020 May 4;9(5). Epub 2020 May 4.

Division of Biotechnology, Department of Chemistry, Center for Chemistry and Chemical Engineering, Lund University, Box 124, 22100 Lund, Sweden.

"Omics" represent a combinatorial approach to high-throughput analysis of biological entities for various purposes. It broadly encompasses genomics, transcriptomics, proteomics, lipidomics, and metabolomics. Bacteria and microalgae exhibit a wide range of genetic, biochemical and concomitantly, physiological variations owing to their exposure to biotic and abiotic dynamics in their ecosystem conditions. Read More

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http://dx.doi.org/10.3390/antibiotics9050229DOI Listing

Whole Transcriptome Analysis Reveals That Modulates TNFα-Stimulated MAPK Activation in Human Neutrophils.

Front Immunol 2020 16;11:497. Epub 2020 Apr 16.

Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, United States.

Periodontitis is an irreversible, bacteria-induced, chronic inflammatory disease that compromises the integrity of tooth-supporting tissues and adversely affects systemic health. As the immune system's first line of defense against bacteria, neutrophils use their microbicidal functions in the oral cavity to protect the host against periodontal disease. However, periodontal pathogens have adapted to resist neutrophil microbicidal mechanisms while still propagating inflammation, which provides essential nutrients for the bacteria to proliferate and cause disease. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179764PMC

Synthetic Biology Approaches to Engineer towards the Industrial Production of Valuable Polyphenolic Compounds.

Life (Basel) 2020 May 2;10(5). Epub 2020 May 2.

Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.

Polyphenols are plant secondary metabolites with diverse biological and potential therapeutic activities such as antioxidant, anti-inflammatory and anticancer, among others. However, their extraction from the native plants is not enough to satisfy the increasing demand for this type of compounds. The development of microbial cell factories to effectively produce polyphenols may represent the most attractive solution to overcome this limitation and produce high amounts of these bioactive molecules. Read More

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http://dx.doi.org/10.3390/life10050056DOI Listing

Current genetic engineering strategies for the production of antihypertensive ACEI peptides.

Biotechnol Bioeng 2020 May 5. Epub 2020 May 5.

Department of Medical Sciences (DCM), Institute of Biomedicine (iBiMED), Universidade de Aveiro, Aveiro, Portugal.

Hypertension is a major and highly prevalent risk factor for various diseases. Among the most frequently prescribed antihypertensive first-line drugs are synthetic angiotensin I-converting enzyme inhibitors (ACEI). However, since  their use in hypertension therapy has been linked to various side effects, interest in the application of food-derived ACEI peptides (ACEIp) as antihypertensive agents is rapidly growing. Read More

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http://dx.doi.org/10.1002/bit.27373DOI Listing
May 2020
4.126 Impact Factor

Recent advances on synthesis and biomaterials applications of hyperbranched polymers.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2020 May 4:e1640. Epub 2020 May 4.

Department of Chemistry and Biochemistry, University of Notre Dame, Indiana, USA.

Hyperbranched polymers represent an intriguing class of shape-persistent soft nanomaterials that could be easily produced in one-pot reaction to obtain highly branched arborescent structures. Although traditional synthesis of hyperbranched polymers suffers from the poorly defined structures and broad molecular weight distribution, recent progress on synthesis methods allows the production of structurally defined polymers in tunable molecular weights, composition and degree of branching. This review summarizes the recent advance on synthesis of hyperbranched polymers and their applications as biomaterials in tissue engineering scaffolds, diagnostic probe carriers and drug delivery fields. Read More

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http://dx.doi.org/10.1002/wnan.1640DOI Listing

Electrochemical biosensors for pathogen detection.

Biosens Bioelectron 2020 Jul 12;159:112214. Epub 2020 Apr 12.

Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, 24061, USA; Department of Materials Science and Engineering, Virginia Tech, Blacksburg, VA, 24061, USA; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, 24061, USA. Electronic address:

Recent advances in electrochemical biosensors for pathogen detection are reviewed. Electrochemical biosensors for pathogen detection are broadly reviewed in terms of transduction elements, biorecognition elements, electrochemical techniques, and biosensor performance. Transduction elements are discussed in terms of electrode material and form factor. Read More

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http://dx.doi.org/10.1016/j.bios.2020.112214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152911PMC

Photosynthetic Conversion of Carbon Dioxide to Oleochemicals by Cyanobacteria: Recent Advances and Future Perspectives.

Front Microbiol 2020 17;11:634. Epub 2020 Apr 17.

State Key Laboratory of Biocatalysis and Enzyme Engineering, Environmental Microbial Technology Center of Hubei Province, School of Life Sciences, Hubei University, Wuhan, China.

Sustainable production of biofuels and biochemicals has been broadly accepted as a solution to lower carbon dioxide emissions. Besides being used as lubricants or detergents, oleochemicals are also attractive biofuels as they are compatible with existing transport infrastructures. Cyanobacteria are autotrophic prokaryotes possessing photosynthetic abilities with mature genetic manipulation systems. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181335PMC
April 2020
3.941 Impact Factor

Nano on micro: tuning microbial metabolisms by nano-based artificial mediators to enhance and expand production of biochemicals.

Curr Opin Biotechnol 2020 Apr 30;64:161-168. Epub 2020 Apr 30.

Department of Biosystems Engineering, Auburn University, Auburn, AL 36849, USA; Center for Bioenergy and Bioproducts, Auburn University, Auburn, AL 36849, USA. Electronic address:

Advances in synthetic biology and metabolic engineering across the past few decades have enabled the successful production of many novel chemicals. However, bioproduction of such chemicals is often limited by low yield and titer due to disrupted metabolic homeostasis. Finely tuning cellular metabolism to restore robust metabolic functions entails various genetic modifications, which is often not practical. Read More

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http://dx.doi.org/10.1016/j.copbio.2020.03.006DOI Listing

Sustainable soil use and management: An interdisciplinary and systematic approach.

Sci Total Environ 2020 Aug 25;729:138961. Epub 2020 Apr 25.

School of Environment, Tsinghua University, Beijing 100084, China.

Soil is a key component of Earth's critical zone. It provides essential services for agricultural production, plant growth, animal habitation, biodiversity, carbon sequestration and environmental quality, which are crucial for achieving the United Nations' Sustainable Development Goals (SDGs). However, soil degradation has occurred in many places throughout the world due to factors such as soil pollution, erosion, salinization, and acidification. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182530PMC
August 2020
4.099 Impact Factor

Non-conventional hosts for the production of fuels and chemicals.

Curr Opin Chem Biol 2020 Apr 26;59:15-22. Epub 2020 Apr 26.

Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway Avenue, Austin, TX, 78712, United States; McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, United States. Electronic address:

Biotechnology offers a green alternative for the production of fuels and chemicals using microbes. Although traditional model hosts such as Escherichia coli and Saccharomyces cerevisiae have been widely studied and used, they may not be the best hosts for industrial application. In this review, we explore recent advances in the use of nonconventional hosts for the production of a variety of fuel, cosmetics, perfumes, food, and pharmaceuticals. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.03.004DOI Listing

Flexible Nitrite Supply Alternative for Mainstream Anammox: Advances in Enhancing Process Stability.

Environ Sci Technol 2020 May 7;54(10):6353-6364. Epub 2020 May 7.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, China.

Anaerobic ammonium oxidation (anammox) has attracted extensive attention as a potentially sustainable and economical municipal wastewater treatment process. However, its large-scale application is limited by unstable nitrite (NO-N) production and associated excessive nitrate (NO-N) residue. Thus, our study sought to evaluate an efficient alternative to the current nitritation-based anammox process substituting NO-N supply by partial-denitrification (PD; NO-N → NO-N) under mainstream conditions. Read More

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http://dx.doi.org/10.1021/acs.est.9b06265DOI Listing

Alkaliphiles: The Versatile Tools in Biotechnology.

Adv Biochem Eng Biotechnol 2020 Apr 28. Epub 2020 Apr 28.

Department of Biotechnology, Lund University, Lund, Sweden.

The extreme environments within the biosphere are inhabited by organisms known as extremophiles. In recent years to Lately, these organisms are attracting a great deal of interest from researchers and industrialists. The motive behind this attraction is mainly related to the desire for new and efficient products of biotechnological importance and human curiosity of understanding nature. Read More

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http://dx.doi.org/10.1007/10_2020_126DOI Listing

Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation.

J Anim Sci Biotechnol 2020 23;11:44. Epub 2020 Apr 23.

Natural Biologics Inc., Newfield, NY 14867 USA.

Ongoing challenges in the swine industry, such as reduced access to antibiotics and virus outbreaks (e.g., porcine epidemic diarrhea virus, African swine fever virus), have prompted calls for innovative feed additives to support pig production. Read More

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http://dx.doi.org/10.1186/s40104-020-00446-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178611PMC

Artificial Molecular Chaperone Systems for Proteins, Nucleic Acids, and Synthetic Molecules.

Bioconjug Chem 2020 May 26;31(5):1259-1267. Epub 2020 Apr 26.

Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

Molecular chaperones play critical roles in biological functions. They are closely involved in the maintenance of cell homeostasis, proper folding of proteins and nucleic acids, and inhibition of irreversible aggregation in denatured proteins. In addition to protein production, molecular chaperone function is widely recognized as important for peptide and protein drug delivery systems. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00133DOI Listing

Latest advances in imaging techniques for characterizing soft, multiphasic food materials.

Adv Colloid Interface Sci 2020 May 8;279:102154. Epub 2020 Apr 8.

School of Food Science and Nutrition, Food Colloids and Bioprocessing group, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK. Electronic address:

Over the last two decades, the development and production of innovative, customer-tailored food products with enhanced health benefits have seen major advances. However, the manufacture of edible materials with tuned physical and organoleptic properties requires a good knowledge of food microstructure and its relationship to the macroscopic properties of the final food product. Food products are complex materials, often consisting of multiple phases. Read More

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http://dx.doi.org/10.1016/j.cis.2020.102154DOI Listing

Recent advances in domesticating non-model microorganisms.

Biotechnol Prog 2020 Apr 23:e3008. Epub 2020 Apr 23.

Department of Chemical and Biomolecular Engineering, Carl R. Woese Institute for Genomic Biology , University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Non-model microorganisms have been increasingly explored as microbial cell factories for production of chemicals, fuels, and materials owing to their unique physiology and metabolic capabilities. However, these microorganisms often lack facile genetic tools for strain development, which hinders their adoption as production hosts. In this review, we describe recent advances in domestication of non-model microorganisms, including bacteria, actinobacteria, cyanobacteria, yeast, and fungi, with a focus on the development of genetic tools. Read More

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http://dx.doi.org/10.1002/btpr.3008DOI Listing

Recent Advances in Bioplastics: Application and Biodegradation.

Polymers (Basel) 2020 Apr 15;12(4). Epub 2020 Apr 15.

UCD Earth Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, 4, D04 N2E5 Dublin, Ireland.

The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. Read More

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http://dx.doi.org/10.3390/polym12040920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240402PMC

Strategies for the production of biochemicals in bioenergy crops.

Biotechnol Biofuels 2020 15;13:71. Epub 2020 Apr 15.

1Joint BioEnergy Institute, Emeryville, CA 94608 USA.

Industrial crops are grown to produce goods for manufacturing. Rather than food and feed, they supply raw materials for making biofuels, pharmaceuticals, and specialty chemicals, as well as feedstocks for fabricating fiber, biopolymer, and construction materials. Therefore, such crops offer the potential to reduce our dependency on petrochemicals that currently serve as building blocks for manufacturing the majority of our industrial and consumer products. Read More

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http://dx.doi.org/10.1186/s13068-020-01707-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158082PMC

Recent advances in polyhydroxyalkanoate production: Feedstocks, strains and process developments.

Int J Biol Macromol 2020 Apr 18;156:691-703. Epub 2020 Apr 18.

Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln 68583, USA; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln 68588, USA; Industrial Agricultural Products Center, University of Nebraska-Lincoln, Lincoln 68583, USA. Electronic address:

Polyhydroxyalkanoates (PHAs) have been actively studied in academia and industry for their properties comparable to petroleum-derived plastics and high biocompatibility. However, the major limitation for commercialization is their high cost. Feedstock costs, especially carbon costs, account for the majority of the final cost. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.04.082DOI Listing