952 results match your criteria Advances In Medical Sciences[Journal]


Iron, ferroptosis, and new insights for prevention in acute kidney injury.

Adv Med Sci 2020 Jun 24;65(2):361-370. Epub 2020 Jun 24.

Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, Warsaw, Poland. Electronic address:

Acute kidney injury (AKI) is a very common condition with high morbidity and mortality, which can be seen in 5-7% of all hospitalized patients and in up to 57% of all intensive care unit admissions. Despite recent advances in clinical care, the prevalence of AKI has been shown to increase with virtually no change in mortality. AKI is a complex syndrome occurring in a variety of clinical settings. Read More

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http://dx.doi.org/10.1016/j.advms.2020.06.004DOI Listing

Gene expression analysis of activating and inhibitory receptors of natural killer cells in patients with acute myeloblastic leukemia.

Adv Med Sci 2020 Jun 24;65(2):354-360. Epub 2020 Jun 24.

Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

Purpose: Natural killer (NK) cells are cytotoxic lymphocytes, which have long been known to play an essential role in immune surveillance of tumor cells. The results of several clinical studies imply evidence of impaired activity of NK cells in acute myeloblastic leukemia (AML). The aim of this study was to investigate the gene expression of activating and inhibitory receptors of NK cells in patients with newly diagnosed AML before and after induction therapy using 7 + 3 regimen in comparison to healthy donors. Read More

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http://dx.doi.org/10.1016/j.advms.2020.05.007DOI Listing

Quantitative changes in selected bacteria in the stool during the treatment of Crohn's disease.

Adv Med Sci 2020 Jun 23;65(2):348-353. Epub 2020 Jun 23.

Jagiellonian University Medical College, Faculty of Medicine, Department of Pediatrics, Gastroenterology and Nutrition, Krakow, Poland. Electronic address:

Purpose: The aim of this study was to determine quantitative changes in selected species of bacteria (Bacteroides fragilis, Lactobacillus fermentum, Lactobacillus rhamnosus, Serratia marcescens) in the stool of patients with Crohn's disease (CD) in the course of induction treatment with exclusive enteral nutrition (EEN) or anti-tumor necrosis factor alpha (Infliximab, IFX) vs. healthy controls (HC).

Materials/methods: DNA was isolated from stool samples of CD (n = 122) and HC (n = 17), and quantitative real-time Polymerase Chain Reaction (qPCR) was applied. Read More

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http://dx.doi.org/10.1016/j.advms.2020.06.003DOI Listing

Anti-fibrotic effect of iguratimod on pulmonary fibrosis by inhibiting the fibroblast-to-myofibroblast transition.

Adv Med Sci 2020 Jun 23;65(2):338-347. Epub 2020 Jun 23.

Department of Rheumatology, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Purpose: Pulmonary fibrosis (PF) is a severe lung disease causing significant morbidity and mortality. PF pathogenesis is attributed to the fibroblast-to-myofibroblast transition (FMT) driven by the most potent pro-fibrogenic factor TGF-β1 activating the Smad3-dependent TGF-β1 canonical pathway. Iguratimod (IGU) is a novel anti-rheumatic drug that suppresses the secretion of inflammatory factors, but is also able to modulate the differentiation of multiple cells. Read More

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http://dx.doi.org/10.1016/j.advms.2020.05.006DOI Listing

Comparison of the offspring ultrasound thyroid volume in hypothyroid mothers treated with different levothyroxine doses: A cohort study.

Adv Med Sci 2020 Jun 21;65(2):332-337. Epub 2020 Jun 21.

Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland. Electronic address:

Purpose: We aimed to determine the volume of the thyroid gland in full-term neonates born to hypothyroid mothers as compared with full-term infants born to healthy mothers and to investigate the association between levothyroxine doses and the thyroid volume of neonates.

Materials And Methods: This is single center prospective observational study of 245 full-term neonates (96 from hypothyroid and 149 from healthy mothers). Ultrasound examination in both longitudinal and transverse projections was used to calculate the thyroid volume applying the ellipsoid formula. Read More

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http://dx.doi.org/10.1016/j.advms.2020.05.004DOI Listing

Effect of ytterbium amount on LaNbO:Tm,Yb nanoparticles for bio-labelling applications.

Adv Med Sci 2020 Jun 17;65(2):324-331. Epub 2020 Jun 17.

Universidade De Franca, Franca, São Paulo, Brazil. Electronic address:

Purpose: This work investigates how Yb concentration affects the luminescent properties of LaNbO nanoparticles for medical imaging applications. Due to the highly transparent optical window for organic tissues in the near infrared region (650-1000 nm), upconversion fluorescence allows near infrared wavelengths to penetrate deeply into tissues, which is useful in biomedical areas such as biodetection, activated phototherapy, and screening.

Materials/method: Upconversion nanoparticles based on LaNbO doped with Tm and Yb were prepared by the one-step industrial process called Spray Pyrolysis. Read More

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http://dx.doi.org/10.1016/j.advms.2020.06.001DOI Listing

Efficacy of ipilimumab after anti-PD-1 therapy in sequential treatment of metastatic melanoma patients - Real world evidence.

Adv Med Sci 2020 Jun 15;65(2):316-323. Epub 2020 Jun 15.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Purpose: Immunotherapy has become a standard treatment option for patients with metastatic melanoma, and the use of checkpoint inhibitors significantly improves the treatment outcomes in this group.

Patients And Methods: A total of 116 patients with metastatic melanoma were enrolled in the study. In the first line, they were treated with an anti-PD-1 inhibitor (nivolumab or pembrolizumab), following which ipilimumab was used as the second-line therapy. Read More

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http://dx.doi.org/10.1016/j.advms.2020.05.005DOI Listing

Characteristics of platelet indices and their prognostic significance in selected medical condition - a systematic review.

Adv Med Sci 2020 Jun 4;65(2):310-315. Epub 2020 Jun 4.

Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Background: Platelets, also called thrombocytes, are produced in bone marrow and are the second most numerous blood cells which circulate in blood and play a pivotal role in hemostasis, wound healing, angiogenesis. There is a large body of evidence that platelets are likely to contribute to inflammation in multiple diseases. Also, recent studies revealed the association between platelet indices (PI) and inflammation. Read More

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http://dx.doi.org/10.1016/j.advms.2020.05.002DOI Listing

Sensitization to major Dermatophagoides pteronyssinus allergens in house dust mite allergic patients from North Eastern Poland developing rhinitis or asthma.

Adv Med Sci 2020 May 28;65(2):304-309. Epub 2020 May 28.

Center of Excellence in Vaccine Research and Development, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Purpose: Recognition of individual allergens by IgE is crucial for triggering symptoms in allergic rhinitis (AR) or asthmatic (AA) patients. House dust mite (HDM) allergy is frequent around the world, the sensitization profile to individual HDM allergens varies in individual HDM-allergic patients (APs). The aim of this study was to evaluate the pattern of IgE sensitization to three major Dermatophagoides pteronyssinus (Dp) allergens among patients from North Eastern Poland suffering from HDM-AR and/or AA. Read More

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http://dx.doi.org/10.1016/j.advms.2020.05.003DOI Listing

Pulmonary vascular resistance as a potential marker of reactive pulmonary hypertension reduction following sildenafil therapy in patients disqualified from orthotopic heart transplantation.

Adv Med Sci 2020 May 23;65(2):298-303. Epub 2020 May 23.

Department of Cardiac Surgery, Heart Transplantation and Mechanical Circulatory Support, Medical University of Silesia, Silesian Center for Heart Disease, Zabrze, Poland.

Purpose: We sought to determine the predictors of restoration of heart transplantation (HTx) candidacy in patients with systolic heart failure (HF) and reactive fixed pulmonary hypertension (RFPH) defined as pulmonary vascular resistance (PVR) > 2.5 Wood units (WU), transpulmonary gradient (TPG) > 12 mmHg or ≤2.5 WU with systolic arterial pressure ≤85 mmHg during vasoreactivity test, following sildenafil therapy. Read More

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http://dx.doi.org/10.1016/j.advms.2020.04.002DOI Listing

Analysis of the tumor necrosis factor superfamily member 11 gene polymorphism with bone mineral density and bone fracture frequency in patients with postmenopausal osteoporosis.

Adv Med Sci 2020 May 20;65(2):291-297. Epub 2020 May 20.

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.

Purpose: We aimed to examine the polymorphism of the promoter and exon 5 of the TNFSF11 gene and their impact on bone mineral density (BMD) and the frequency of bone fractures. TNFSF11 encodes the receptor activator of the NF-kB ligand (RANKL), a key regulator of bone metabolism and osteoporosis drug targets. BMD is an essential measure in diagnosing osteoporosis and assessing the risk of fractures. Read More

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http://dx.doi.org/10.1016/j.advms.2020.05.001DOI Listing

Brain tissue oxygenation during transnasal endoscopic skull base procedures.

Adv Med Sci 2020 Apr 30;65(2):286-290. Epub 2020 Apr 30.

Department of Neurosurgery, Medical University of Bialystok, Bialystok, Poland.

Purpose: We aimed to study brain tissue oxygenation during the period of controlled reduction of arterial blood pressure - a maneuver often used in extended endoscopic skull base surgery for bloodless operative field.

Methods: Intracranial pressure, arterial blood pressure and the resultant cerebral perfusion pressure were measured during extended endoscopic skull base surgery in 5 patients with diagnosed tumors of the skull base and arterial hypertension. Simultaneously, in those patients, we measured partial pressure of oxygen in the brain parenchyma (PbtO). Read More

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http://dx.doi.org/10.1016/j.advms.2020.03.003DOI Listing

Neurotoxicity of antineoplastic drugs: Mechanisms, susceptibility, and neuroprotective strategies.

Adv Med Sci 2020 Apr 28;65(2):265-285. Epub 2020 Apr 28.

Emergency Department, Poison Control Center, Hospital Papa Giovanni XXIII, Bergamo, Italy. Electronic address:

This review summarizes the adverse effects on the central and/or peripheral nervous systems that may occur in response to antineoplastic drugs. In particular, we describe the neurotoxic side effects of the most commonly used drugs, such as platinum compounds, doxorubicin, ifosfamide, 5-fluorouracil, vinca alkaloids, taxanes, methotrexate, bortezomib and thalidomide. Neurotoxicity may result from direct action of compounds on the nervous system or from metabolic alterations produced indirectly by these drugs, and either the central nervous system or the peripheral nervous system, or both, may be affected. Read More

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http://dx.doi.org/10.1016/j.advms.2020.04.001DOI Listing

Correlation between biomarkers (calprotectin, seromucoid, metalloproteinase-3 and CRP) and clinical and endoscopic activity of ulcerative colitis in children.

Adv Med Sci 2020 Apr 28;65(2):259-264. Epub 2020 Apr 28.

Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Wroclaw, Poland.

Purpose: The aim of the study was to compare the clinical activity and inflammatory markers with the endoscopic activity of ulcerative colitis (UC) and mucosal healing.

Patients And Methods: The study included 50 children aged 2-18 years (27 girls, 23 boys) diagnosed with UC at various stages of the disease; 8 children were assessed twice. In 20 children, colonoscopy revealed pancolitis, in 24 - left-sided colitis, and in 6 - ulcerative proctitis. Read More

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http://dx.doi.org/10.1016/j.advms.2020.03.004DOI Listing

miR-141-3p promotes proliferation and metastasis of nasopharyngeal carcinoma by targeting NME1.

Adv Med Sci 2020 Apr 13;65(2):252-258. Epub 2020 Apr 13.

Department of Otolaryngology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address:

Purpose: This study aimed to investigate the expression and biological function of miR-141-3p in nasopharyngeal carcinoma (NPC) via targeting neoplasm metastasis 1 (NME1).

Materials And Methods: The expression of miR-141-3p and NME1 in 5-8F, C666-1, CNE-1, CNE-2, 6-10B and NP69 nasopharyngeal epithelial cells were detected using real-time Polymerase Chain Reaction (real-time PCR) and western blot, respectively. Cell proliferation was detected using Cell Counting Kit-8 (CCK-8), and the metastasis was detected using Transwell. Read More

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http://dx.doi.org/10.1016/j.advms.2020.03.005DOI Listing

The beneficial role of FeNO in association with GINA guidelines for titration of inhaled corticosteroids in adult asthma: A randomized study.

Adv Med Sci 2020 Apr 7;65(2):244-251. Epub 2020 Apr 7.

Department of Respiratory Diseases, Lam Dong Medical College, Dalat City, Vietnam; Department of Immuno-Allergology, Penn State Medical College, Hershey, USA. Electronic address:

Purpose: This study aimed to demonstrate the role of fractional concentration of exhaled nitric oxide (FeNO) in association with Global Initiative for Asthma (GINA) guidelines for treatment of adult patients with asthma.

Methods: It was a prospective and randomized study. The symptomatic asthmatic patients were randomly divided into two groups: GINA group (followed GINA guidelines; N = 86) or GINA + FeNO group (followed GINA guidelines + FeNO for titration of inhaled corticosteroids - ICS; N = 90). Read More

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http://dx.doi.org/10.1016/j.advms.2020.03.001DOI Listing

Clarithromycin effectively enhances doxorubicin-induced cytotoxicity and apoptosis in MCF7 cells through dysregulation of autophagy.

Adv Med Sci 2020 Apr 3;65(2):235-243. Epub 2020 Apr 3.

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Purpose: Use of autophagy inhibitors in combination with chemotherapy has become a novel chemotherapeutic strategy. In this study, we aimed to determine whether the effectiveness of doxorubicin (DOX) is augmented by clarithromycin (CAM) in MCF7 cells and the molecular mechanisms involved.

Materials And Methods: Combined cytotoxicity of CAM and DOX was assessed by MTT assay and was analyzed using the Chou-Talalay's method. Read More

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http://dx.doi.org/10.1016/j.advms.2020.03.002DOI Listing
April 2020
0.964 Impact Factor

He said, she said: Sex differences in peripheral artery disease.

Adv Med Sci 2020 03 13;65(1):233-234. Epub 2020 Mar 13.

Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.advms.2020.02.003DOI Listing

Auditory evoked potentials might have the potential to serve as early indicators related to amyloid beta peptide toxicity.

Adv Med Sci 2020 Mar 29;65(1):223-232. Epub 2020 Feb 29.

Department of Biophysics, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Purpose: Accumulation of amyloid beta (Aβ) is thought to be the major cause of the development and progression of Alzheimer's disease (AD). The aim of this study is to elucidate the effects of Aβ at increasing concentrations on auditory evoked potentials (AEPs) and to determine possible changes relevant to the accumulation of Aβ.

Materials And Methods: In this study, rats were randomized to following groups (n = 10 per group): sham (0. Read More

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http://dx.doi.org/10.1016/j.advms.2020.02.001DOI Listing

Value of magnetic resonance enterography in diagnosis and treatment follow up in Crohn's disease in children.

Adv Med Sci 2020 Mar 20;65(1):214-222. Epub 2020 Feb 20.

2nd Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Wroclaw, Poland.

Purpose: Crohn's disease (CD) is a chronic inflammatory disease which can affect all parts of the gastrointestinal tract. Magnetic resonance enterography (MRE) enables detection of pathologic changes in the small intestine, which are not accessible by conventional endoscopy. The aim of the study was to assess the value of MRE in imaging of small bowel lesions, their location and extent, in CD patients and its correlation with clinical and endoscopic activity. Read More

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http://dx.doi.org/10.1016/j.advms.2020.01.005DOI Listing

Role of Apelin/APJ axis in cancer development and progression.

Adv Med Sci 2020 Mar 19;65(1):202-213. Epub 2020 Feb 19.

Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, prostate, thymus, testis, ovary, lungs, kidneys, stomach, and adipose tissue. The apelin/APJ axis is involved in a number of physiological and pathological processes. Read More

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http://dx.doi.org/10.1016/j.advms.2020.02.002DOI Listing

Gender differences and long-term clinical outcomes in patients with chronic total occlusions of infrainguinal lower limb arteries treated from retrograde access with peripheral vascular interventions.

Adv Med Sci 2020 Mar 31;65(1):197-201. Epub 2020 Jan 31.

2nd Department of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland; 2nd Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland.

Purpose: We sought to investigate gender-related differences in clinical outcomes after peripheral vascular interventions (PVIs) from retrograde access in patients with chronic total occlusions (CTOs) of the infrainguinal arteries.

Patients And Methods: A total of 939 consecutive patients undergoing PVI were enrolled in the study. Patients with peripheral artery diseases (PAD) and CTOs were treated with PVI from retrograde access according to the local protocol. Read More

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http://dx.doi.org/10.1016/j.advms.2020.01.004DOI Listing
March 2020
0.964 Impact Factor

Sexual disorders and dyspnoea among women with obstructive sleep apnea.

Adv Med Sci 2020 Mar 27;65(1):189-196. Epub 2020 Jan 27.

Department of Pneumonology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Purpose: We aimed to assess sexual function, sexual distress and the prevalence of female sexual dysfunction (FSD) among women with obstructive sleep apnea syndrome (OSA), and to assess if the presence of OSA and dyspnea influences the prevalence of FSD, body image during sexual activity and sexual function.

Methods: We assessed 23 women with new OSA diagnosis and 23 healthy age and body mass index (BMI) matched controls. Sexual functions were evaluated by Changes in Sexual Functioning Questionnaire (CSFQ), sexual dysfunction was diagnosed based on DSM-5 criteria during the semi-structured sexual interview, whereas body image was evaluated by Body Exposure during Sexual Activities Questionnaire (BESAQ). Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.003DOI Listing

The effect of medical treatment on nasal exhaled nitric oxide (NO) in patients with persistent allergic rhinitis: A randomized control study.

Adv Med Sci 2020 Mar 21;65(1):182-188. Epub 2020 Jan 21.

Clinical Research Center, Lam Dong Medical College, Dalat City, Viet Nam; Department of Immuno-Allergology, Penn State Medical College, Hershey, USA. Electronic address:

Purpose: This study aimed to evaluate the role of nasal nitric oxide (NO) in the management of patients with persistent allergic rhinitis (PER).

Methods: It was a randomized and comparative study. The study subjects were classified as controls (healthy subjects) or patients with PER based on defined criteria. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.004DOI Listing

Plasma level of laminin 5 and collagen IV in cryptorchidism.

Adv Med Sci 2020 Mar 21;65(1):176-181. Epub 2020 Jan 21.

Department of Pediatric Surgery and Urology, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Purpose: Laminin 5 and collagen IV are the main compounds of the extracellular matrix of the germinal epithelium. The purpose of this study was to evaluate the concentration of these two markers of fibrosis in the plasma of boys with congenital unilateral cryptorchidism.

Materials And Methods: The study group comprised 43 boys aged 1-3 years with congenital unilateral cryptorchidism. Read More

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http://dx.doi.org/10.1016/j.advms.2019.10.004DOI Listing

Geographic disparities in the application of endovascular repair of unruptured abdominal aortic aneurysm - Polish population analysis.

Adv Med Sci 2020 Mar 21;65(1):170-175. Epub 2020 Jan 21.

Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.

Purpose: Differences between the regions of the same country regarding the management of abdominal aortic aneurysm (AAA) have rarely been published. The aim of the study was to analyze the absolute and relative number of unruptured AAA repairs, utilizing endovascular aneurysm repair (EVAR) vs. open aneurysm repairs (OAR) and compare the AAA patients population from all 16 administrative districts in Poland. Read More

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http://dx.doi.org/10.1016/j.advms.2020.01.003DOI Listing

Single-cell analysis on stromal fibroblasts in the microenvironment of solid tumours.

Authors:
Marahaini Musa

Adv Med Sci 2020 Mar 20;65(1):163-169. Epub 2020 Jan 20.

Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Electronic address:

Besides malignant cells, the tumour microenvironment consists of various stromal cells such as cancer-associated fibroblasts (CAFs) and myofibroblasts. Accumulation of heterogeneous populations of stromal cells in solid tumours is associated with lower survival rates and cancer recurrence in patients. Certain limitations presented by conventional experimental designs and techniques in cancer research have led to poor understanding of the fundamental basis of cancer niche. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.001DOI Listing

Treatment and its side effects in ANCA-associated vasculitides - Study based on POLVAS registry data.

Adv Med Sci 2020 Mar 17;65(1):156-162. Epub 2020 Jan 17.

2nd Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland. Electronic address:

Purpose: The aim of this study is to present the treatment modalities and associated side effects in a Polish nation-wide ANCA-associated vasculitides (AAV) patients' cohort.

Materials And Methods: Retrospective analysis of patients diagnosed with AAV between 1990 and 2016, included in the POLVAS registry was performed. Standard descriptive statistic methods were used with an emphasis on the treatment modalities. Read More

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http://dx.doi.org/10.1016/j.advms.2020.01.002DOI Listing

Influence of infiltration anaesthesia on perioperative outcomes following lumbar discectomy under surgical pleth index-guided general anaesthesia: A preliminary report from a randomised controlled prospective trial.

Adv Med Sci 2020 Mar 13;65(1):149-155. Epub 2020 Jan 13.

Department of Neurosurgery, Regional Hospital in Sosnowiec, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland. Electronic address:

Purpose: Severe postoperative pain (SPP) may occur after lumbar discectomy. To prevent SPP and reduce rescue opioid consumption, infiltration anaesthesia (IA) has been combined with general anaesthesia (GA). This study verified how GA combined with IA facilitated intra- and postoperative demand for opioids and affected the incidence of SPP in patients subjected to open lumbar discectomy. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.006DOI Listing

Total blood lymphocyte count as a prognostic factor among unselected inpatients.

Adv Med Sci 2020 Mar 10;65(1):141-148. Epub 2020 Jan 10.

Department of Vascular and Internal Diseases, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. Electronic address:

Purpose: The aim of this study was to determine the relationships between total lymphocyte count (TLC) and prognosis among inpatients.

Patients And Methods: We retrospectively analyzed data from electronic medical documentation of 54 976 inpatients hospitalized in an urban university hospital during 3 consecutive years (2014-2017).

Results: TLC was available for 12 651 (23. Read More

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http://dx.doi.org/10.1016/j.advms.2020.01.001DOI Listing

Mechanism of pro-apoptotic action of prosthetic restorations on oral mucosa cells.

Adv Med Sci 2020 Mar 10;65(1):134-140. Epub 2020 Jan 10.

Department of Histology and Cytophysiology, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Purpose: The aim of this study was to check the pro-apoptotic mechanism of prosthetic reconstruction on epithelial cells of the oral mucosa.

Patients And Methods: The research was carried out on the saliva of healthy patients using prostheses. The sample swabs were stained using the May-Grünwald-Giemsa method and processed by immunohistochemistry for nuclear factor kappa B (NF-κB; p65) and caspase-3. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.010DOI Listing

Nasal nitric oxide in upper airways in children with asthma and allergic rhinitis.

Adv Med Sci 2020 Mar 10;65(1):127-133. Epub 2020 Jan 10.

Faculty of Medicine, Rzeszów University, Rzeszów, Poland; Allergology Outpatient Department, Provincial Hospital No 2, Rzeszow, Poland.

Purpose: The aim of this study is to compare levels of nasal nitric oxide (nNO) in pediatric patients with respiratory diseases.

Materials And Methods: nNO was measured by an electrochemical analyzer in 179 patients aged 7-15 with asthma, allergic rhinitis or with asthma and allergic rhinitis and in healthy children recruited from a local allergology clinic. Correlations between nNO levels and patient clinical parameters were assessed. Read More

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http://dx.doi.org/10.1016/j.advms.2019.11.005DOI Listing

Changes in circulating endothelial microvesicles in men after myocardial infarction.

Adv Med Sci 2020 Mar 8;65(1):120-126. Epub 2020 Jan 8.

Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of the Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Center of Laboratory Medicine, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania.

Purpose: The objective of the study was to determine the differences in the numbers of endothelial microvesicles (EMV) after myocardial infarction (MI) and their association with oxidative stress.

Materials And Methods: We included 15 post MI patients and 28 healthy controls. Samples were analysed by flow cytometry. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.002DOI Listing

Elevated levels of d-dimer are associated with inflammation and disease activity rather than risk of venous thromboembolism in patients with granulomatosis with polyangiitis in long term observation.

Adv Med Sci 2020 Mar 7;65(1):97-101. Epub 2020 Jan 7.

Department of Family Medicine, Internal and Metabolic Diseases, Medical University of Warsaw, Warsaw, Poland.

Purpose: Granulomatosis with polyangiitis (GPA) is one of antineutrophil cytoplasmic autoantibody (ANCA) - associated vasculitis. The disease is characterized by necrotizing inflammation of small vessels causing tissue ischemia in a variety of organs. The aim of the present study was an evaluation of inflammation, coagulation and fibrinolysis biomarkers, and their possible associations with various clinical and laboratory parameters in GPA patients. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.007DOI Listing

Proven and unproven methods for diagnosis and treatment of infertility.

Adv Med Sci 2020 Mar 7;65(1):93-96. Epub 2020 Jan 7.

Department of Gynecology and Gynecological Oncology, Medical University in Bialystok, Bialystok, Poland.

Infertility and subfertility affect a significant part of the population. Among various definitions of this pathology, the most common one is provided by the World Health Organisation; it says that infertility is 'a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourses'. The global prevalence of infertility is about 50-70 million couples. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.008DOI Listing

Antibody-free rapid diagnosis of malaria in whole blood with surface-enhanced Raman Spectroscopy using Nanostructured Gold Substrate.

Adv Med Sci 2020 Mar 7;65(1):86-92. Epub 2020 Jan 7.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Purpose: The aim of this study is to establish a rapid antibody-free diagnostic method of malaria infection with Plasmodium falciparum and Plasmodium vivax in whole blood with Surface-enhanced Raman Spectroscopy using Nanostructured Gold Substrate.

Materials And Methods: The blood samples collected from patients were first lysed and centrifuged before dropping on the gold nano-structure (AuNS) substrate. Malaria diagnosis was performed by detecting Raman peaks from Surface Enhanced Raman Spectroscopy (SERS) with a 532 nm laser excitation. Read More

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http://dx.doi.org/10.1016/j.advms.2019.11.004DOI Listing
March 2020
0.964 Impact Factor

Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.

Adv Med Sci 2020 Mar 7;65(1):111-119. Epub 2020 Jan 7.

The Bert Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel; Achva Academic College, Beer-Tuvia Regional Council, Arugot, Israel. Electronic address:

Purpose: Lipoxygenases (LOX) have been implicated in carcinogenesis, however both pro- and anti-carcinogenic effects have been reported in different cancer models. Using transgenic mice, which specifically overexpress human 15-lipoxygenase (ALOX15) in endothelial cells (EC), we previously demonstrated significant inhibition of tumor development. In the Lewis lung carcinoma (LLC) model, the primary tumor developed similarly in both wild type (WT) and ALOX15 overexpressing mice. Read More

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http://dx.doi.org/10.1016/j.advms.2019.11.006DOI Listing

Chemokines profile in patients with chronic heart failure treated with cardiac resynchronization therapy.

Adv Med Sci 2020 Mar 7;65(1):102-110. Epub 2020 Jan 7.

Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Purpose: Inflammatory mechanisms have been suggested to play a role in the heart failure with reduced ejection fraction (HF-REF) development, but the role of chemokines is largely unknown. Cardiac resynchronization therapy (CRT) may reverse the HF-REF course. We aimed to evaluate selected chemokines concentrations in HF-REF patients and their relationship with disease severity and clinical response to CRT. Read More

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http://dx.doi.org/10.1016/j.advms.2019.11.007DOI Listing

Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes.

Adv Med Sci 2020 Mar 7;65(1):78-85. Epub 2020 Jan 7.

Laboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, Larissa, Greece; Department of Biology, Faculty of Medicine, Larissa, University of Thessaly, Greece. Electronic address:

Purpose: MiR-146a acts as a negative inflammatory mediator in different diseases and has been implicated in osteoarthritis (OA) pathogenesis. In our study, we investigated the association between miR-SNP rs2910164 and OA susceptibility and its role on the expression of miR-146a, inflammatory and catabolic mediators in osteoarthritic chondrocytes.

Materials And Methods: Genetic association analysis was performed in 1688 knee OA patients and healthy individuals of Greek origin. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.005DOI Listing
March 2020
0.964 Impact Factor

CRB1 mutation influences the age-related macular degeneration phenotype of NRF2 knockout mice and favors choroidal neovascularization.

Adv Med Sci 2020 Mar 7;65(1):71-77. Epub 2020 Jan 7.

Christian-Albrechts-University of Kiel, University Medical Center, Kiel, Germany. Electronic address:

Purpose: We examined the influence of retinal degeneration 8 (rd8) mutation of crumbs homolog 1 (CRB1) gene on age-related macular degeneration (AMD) phenotype in nuclear factor E2-related factor 2 knock out (NRF2) mouse model.

Methods: CRB1 mutation genotype was determined by polymerase chain reaction from tail clips in 73 NRF2 mice originating from C57BL/6J background on mixed C57BL/6J and C57BL/6N ancestry. The clinical grade of AMD-like fundus alterations was determined by funduscopy, optical coherence tomography (OCT) and fluorescein angiography (FLA) at the age of 9 or 12 months. Read More

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http://dx.doi.org/10.1016/j.advms.2019.11.003DOI Listing

Metabolomic profiling in children with inflammatory bowel disease.

Adv Med Sci 2020 Mar 2;65(1):65-70. Epub 2020 Jan 2.

Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.

Ulcerative colitis (UC) and Crohn's disease (CD) represent inflammatory bowel diseases (IBD) with multifactorial pathogenesis, involving genetic, environmental and microbial factors. Interactions between gut microbiota and immune system result in changes in metabolic pathways. Metabolomics is a comprehensive and quantitative (or semi-quantitative) analysis of metabolites synthetized in human's biological system. Read More

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http://dx.doi.org/10.1016/j.advms.2019.12.009DOI Listing

Life with the pancreas: A personal experience.

Authors:
Jean Morisset

Adv Med Sci 2020 Mar 31;65(1):46-64. Epub 2019 Dec 31.

Division of Gastroenterology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, Québec, J1H 5N4, Canada. Electronic address:

This review article has primary objective to summarize pancreatic research which has been done in our laboratory since 1965, the first year of the author's registration in the Ph.D. program at the University of Sherbrooke (Canada). Read More

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http://dx.doi.org/10.1016/j.advms.2019.11.002DOI Listing

Vitamin D deficiency and thyroid autoantibody fluctuations in patients with Graves' disease - A mere coincidence or a real relationship?

Adv Med Sci 2020 Mar 27;65(1):39-45. Epub 2019 Dec 27.

Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.

Purpose: The aim of this study was to evaluate the association between vitamin D (vitD) and changes in the titers of anti-TSH receptor (TSHR-Abs), antithyroglobulin (Tg-Abs), and antiperoxidase (TPO-Abs) autoantibodies.

Materials/methods: The study involved 269 patients with Graves' disease (GD), divided into four subgroups (1-4), i.e. Read More

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http://dx.doi.org/10.1016/j.advms.2019.11.001DOI Listing

Normal tolerance limits for side-to-side differences in diameters of major lower limbs arteries of 228 healthy subjects.

Adv Med Sci 2020 Mar 24;65(1):30-38. Epub 2019 Dec 24.

Institute of Innovative Medicine, Biomedical Advanced Image Laboratory, Bialystok, Poland.

Purpose: To determine reference values and tolerance limits of between-side differences for the calibers of the common femoral artery (CFA), superficial femoral artery (SFA), popliteal artery (PA), dorsalis pedis artery (DPA), and posterior tibial artery (PTA).

Materials And Methods: Calibers of arteries, defined as the largest distance between internal hyperechogenic lines of the intima-media complex of the arterial wall, were measured during the diastole phase determined from echo-tracking B mode ultrasound scanning and grey-scale ultrasound in 228 healthy volunteers aged 18-81 years (43.1 ± 16. Read More

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http://dx.doi.org/10.1016/j.advms.2019.10.001DOI Listing

The clinical applications of a multigene liquid biopsy (NETest) in neuroendocrine tumors.

Adv Med Sci 2020 Mar 13;65(1):18-29. Epub 2019 Dec 13.

Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT, USA.

Purpose: There are few effective biomarkers for neuroendocrine tumors. Precision oncology strategies have provided liquid biopsies for real-time and tailored decision-making. This has led to the development of the first neuroendocrine tumor liquid biopsy (the NETest). Read More

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http://dx.doi.org/10.1016/j.advms.2019.10.002DOI Listing

Comparative effectiveness of 8 versus 12 weeks of Ombitasvir/Paritaprevir/ritonavir and Dasabuvir in treatment-naïve patients infected with HCV genotype 1b with non-advanced hepatic fibrosis.

Adv Med Sci 2020 Mar 13;65(1):12-17. Epub 2019 Dec 13.

Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Białystok, Poland.

Purpose: Since 2017 treatment-naïve patients infected with genotype 1b of hepatitis C virus and minimal or moderate fibrosis can be treated with Ombitasvir/Paritaprevir/ritonavir + Dasabuvir (OPrD) for 8 weeks according to updated Summary of Product Characteristics. The aim of our study was to assess the comparative efficacy of 8 and 12-weeks therapy with OPrD in large cohort of patients eligible for 8 weeks regimen treated in real-world setting.

Materials And Methods: We analysed data of 3067 HCV genotype 1b infected patients treated with OPrD between 2015 and 2017. Read More

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http://dx.doi.org/10.1016/j.advms.2019.09.002DOI Listing

Unveiling the genetic etiology of primary ciliary dyskinesia: When standard genetic approach is not enough.

Adv Med Sci 2020 Mar 10;65(1):1-11. Epub 2019 Dec 10.

Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal; Multidisciplinary Unit for Biomedical Research, Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal. Electronic address:

Purpose: Primary ciliary dyskinesia (PCD) is a ciliopathy caused by dysfunction of motile cilia. As there is still no standard PCD diagnostics, the final diagnosis requires a combination of several tests. The genetic screening is a hallmark for the final diagnosis and requires high-throughput techniques, such as whole-exome sequencing (WES). Read More

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http://dx.doi.org/10.1016/j.advms.2019.10.003DOI Listing

Comparison of the QuantiFERON-TB Gold Plus and QuantiFERON-TB Gold In-Tube interferon-γ release assays: A systematic review and meta-analysis.

Adv Med Sci 2019 Sep 3;64(2):437-443. Epub 2019 Oct 3.

Pediatric Infectious Disease Research Center, Tehran University of Medical Science, Tehran, Iran. Electronic address:

Purpose: QuantiFERON-TB Gold Plus (QFT-Plus) is a new generation of QuantiFERON assay that differs from QuantiFERON-TB Gold In-Tube test (QFT-GIT). The aim of this study was to compare the performance of the new FDA-approved QFT-Plus interferon (IFN)-γ release assays (IGRAs) with the QFT-GIT version of this assay.

Material And Methods: We searched all studies published in English in electronic databases, including PubMed, Scopus, and Web of Science. Read More

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http://dx.doi.org/10.1016/j.advms.2019.09.001DOI Listing
September 2019
1 Read

Expression of several long noncoding RNAs in peripheral blood mononuclear cells of patients with systemic lupus erythematosus.

Adv Med Sci 2019 Sep 27;64(2):430-436. Epub 2019 Sep 27.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui, China. Electronic address:

Purpose: Accumulating evidence has linked long noncoding RNAs (lncRNAs) to autoimmune and inflammatory disorders. This study aimed to detect the expression levels of five lncRNAs (lnc0640, lnc3643, lnc5150, lnc7514 and lncagf) in peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as well as their correlation with clinical and laboratory features.

Materials/methods: We recruited 76 patients with SLE and 71 normal controls into the present study, and obtained PBMCs from the blood samples of all study subjects. Read More

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http://dx.doi.org/10.1016/j.advms.2019.08.002DOI Listing
September 2019
2 Reads
0.964 Impact Factor

Cell adhesion molecules in endometrial cancer - A systematic review.

Adv Med Sci 2019 Sep 17;64(2):423-429. Epub 2019 Sep 17.

Department of General Pathomorphology, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Adhesive molecules are responsible for the cell-cell interaction and the surrounding intercellular environment creating normal tissue architecture. The role of adhesion proteins in cancer refers to angiogenesis, loss of tissue continuity, and deprivation of intercellular contact with the extracellular matrix, promoting the spread of cancer through the formation of metastases. The integrity of the epithelium is disturbed - with disturbances in the whole mechanism of cell connections, thanks to which cancer cells infiltrate surrounding tissues, and move to lymphatic and blood vessels. Read More

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http://dx.doi.org/10.1016/j.advms.2019.08.003DOI Listing
September 2019