889 results match your criteria Advances In Medical Sciences[Journal]


Ultrasound images in hepatic alveolar echinococcosis and clinical stage of the disease.

Adv Med Sci 2019 Apr 16;64(2):324-330. Epub 2019 Apr 16.

Department of Tropical and Parasitic Diseases, University Centre of Maritime and Tropical Medicine (UCMMiT), Medical University of Gdansk, Gdynia, Poland; Department of Tropical Medicine and Epidemiology, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, Gdynia, Poland.

Purpose: Hepatic alveolar echinococcosis (AE) is a parasitic disease caused by the larval stage of the tapeworm Echinococcus multilocularis. Ultrasonography is the method of choice in the initial diagnosis of AE. The aim of the study is to present the most frequent sonomorphological patterns of lesions in hepatic AE based on the analysis of ultrasound findings in patients treated for AE at the University Centre of Maritime and Tropical Medicine (UCMMiT; Gdynia, Poland), and to establish whether there is a relationship between the clinical stage of AE and the occurrence of a specific sonomorphological pattern of hepatic lesions. Read More

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http://dx.doi.org/10.1016/j.advms.2019.04.002DOI Listing
April 2019
1 Read

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.

Adv Med Sci 2019 Apr 9;64(2):315-323. Epub 2019 Apr 9.

Department of Medicine A, University Medicine Greifswald, Greifswald, Germany. Electronic address:

The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins. The fraction of protein passing through the ER represents a large proportion of the total protein in the cell. Protein folding, glycosylation, sorting and transport are essential tasks of the ER and a compromised ER folding network has been recognized to be a key component in the disease pathogenicity of common neurodegenerative, metabolic and malignant diseases. Read More

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http://dx.doi.org/10.1016/j.advms.2019.03.004DOI Listing

Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary circulation in patients with systemic sclerosis.

Adv Med Sci 2019 Apr 8;64(2):309-314. Epub 2019 Apr 8.

Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland.

Purpose: Pulmonary hypertension (PH) is an ominous complication in systemic sclerosis patients (SSc) and echocardiography is a screening tool for its detection. The goal of this study was to assess the reliability of resting and exercise echo Doppler parameters with data obtained by right heart catheterization (RHC).

Material And Methods: We included 91 patients (84 F, 53. Read More

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http://dx.doi.org/10.1016/j.advms.2019.03.006DOI Listing
April 2019
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Clinical importance of sex differences in dyspnea and its sex related determinants in asthma and COPD patients.

Adv Med Sci 2019 Apr 3;64(2):303-308. Epub 2019 Apr 3.

Department of Pneumonology in Katowice, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Purpose: There is an increasing amount of data regarding the influence of sex on dyspnea perception, however, the influence of sex has not been included in clinical guidelines for asthma and chronic obstructive pulmonary disease (COPD).

Materials And Methods: The study included 123 clinically stable subjects. Seventy five patients had COPD, of which 70. Read More

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http://dx.doi.org/10.1016/j.advms.2019.03.003DOI Listing
April 2019
2 Reads

Diagnostic accuracy of frontotemporal dementia. An artificial intelligence-powered study of symptoms, imaging and clinical judgement.

Adv Med Sci 2019 Apr 1;64(2):292-302. Epub 2019 Apr 1.

Bristol Institute of Clinical Neurosciences, University of Bristol, Southmead Hospital, Bristol, UK.

Purpose: Frontotemporal dementia (FTD) is a neurodegenerative disorder associated with a poor prognosis and a substantial reduction in quality of life. The rate of misdiagnosis of FTD is very high, with patients often waiting for years without a firm diagnosis. This study investigates the current state of the misdiagnosis of FTD using a novel artificial intelligence-based algorithm. Read More

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http://dx.doi.org/10.1016/j.advms.2019.03.002DOI Listing
April 2019
1 Read

Combined pulmonary fibrosis and emphysema: How does cohabitation affect respiratory functions?

Adv Med Sci 2019 Apr 1;64(2):285-291. Epub 2019 Apr 1.

Department of Chest Disease, Ankara University School of Medicine, Ankara, Turkey.

Purpose: Combined pulmonary fibrosis and emphysema (CPFE) has emerged as a new syndrome with characteristics of both fibrosis and emphysema. We determined the impacts of radiologic emphysema severity on pulmonary function tests (PFTs), exercise capacity and mortality.

Patients And Methods: IPF patients (n = 110) diagnosed at the Chest Diseases Clinic between September 2013 and January 2016 were enrolled in the study and followed up until June 2017. Read More

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http://dx.doi.org/10.1016/j.advms.2019.03.005DOI Listing
April 2019
2 Reads

Can hepatokines be regarded as novel non-invasive serum biomarkers of intrahepatic lipid content in obese children?

Adv Med Sci 2019 Mar 25;64(2):280-284. Epub 2019 Mar 25.

Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Bialystok, Poland.

Purpose: Hepatokines are proteins produced by the liver and involved in regulating glucose and lipid metabolism. However, their role as the biomarkers of intrahepatic lipid content is not clear. The aim of the study was to evaluate the serum concentration of selected hepatokines: fibroblast growth factor-21 (FGF-21), selenoprotein P (SELENOP) and sex hormone-binding globulin (SHBG) in obese children. Read More

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http://dx.doi.org/10.1016/j.advms.2019.02.005DOI Listing
March 2019
4 Reads

Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion.

Adv Med Sci 2019 Mar 19;64(2):274-279. Epub 2019 Mar 19.

Laboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Purpose: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity of genes responsible for the maintenance of epigenetic stability. Read More

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http://dx.doi.org/10.1016/j.advms.2019.03.001DOI Listing
March 2019
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Contribution of sialic acids to integrin α5β1 functioning in melanoma cells.

Adv Med Sci 2019 Mar 4;64(2):267-273. Epub 2019 Mar 4.

Department of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland.

Purpose: To establish the relationship between sialylation of integrin α5β1 and possible alteration in the function of α5β1 receptor in melanoma cells.

Materials And Methods: Integrin α5β1 was isolated from primary WM115 (RGP/VGP-like phenotype) and metastatic WM266-4 (lymph node metastasis) cells via affinity chromatography. Integrin α5β1 sialylation and the shift in relative masses of the enzymatically desialylated subunits were confirmed by confocal microscopy and SDS-PAGE, respectively. Read More

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http://dx.doi.org/10.1016/j.advms.2019.02.002DOI Listing
March 2019
6 Reads

IL-1α and IL-6 predict vascular events or death in patients with cerebral small vessel disease-Data from the SHEF-CSVD study.

Adv Med Sci 2019 Mar 4;64(2):258-266. Epub 2019 Mar 4.

Clinic of Neurology, Military Institute of Medicine, Warsaw, Poland.

Purpose: The natural clinical course of cerebral small vessel disease (CSVD) was not thoroughly described. The aim of this single center cohort study was to establish biochemical predictors of vascular events and death in CSVD patients during a 24-month follow-up.

Patients And Methods: A total of 130 functionally independent patients with marked MRI features of CSVD and recent lacunar stroke (n = 52,LS), vascular Parkinsonism (n = 28,VaP) or dementia (n = 50,VaD) were prospectively recruited. Read More

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http://dx.doi.org/10.1016/j.advms.2019.02.003DOI Listing
March 2019
3 Reads

Novel potential biomarkers for pancreatic cancer - A systematic review.

Adv Med Sci 2019 Mar 4;64(2):252-257. Epub 2019 Mar 4.

Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland; Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Background: It is estimated that in developed countries the incidence rate of pancreatic cancer (PC) will continue to rise and by 2020 will be the second most fatal cancer. The mortality of PC patients closely parallels the incidence rate, as this malignancy remains asymptomatic until it reaches an advanced stage of disease. Thus, novel biochemical markers that improve the management of PC patients are necessary. Read More

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http://dx.doi.org/10.1016/j.advms.2019.02.004DOI Listing

Clinical characteristics of autoimmune pancreatitis with IgG4 related kidney disease.

Adv Med Sci 2019 Feb 27;64(2):246-251. Epub 2019 Feb 27.

Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.

Purpose: To clarify the clinical characteristics of autoimmune pancreatitis (AIP) in immunoglobulin (Ig)G4-related kidney disease (IgG4-RKD).

Patients And Methods: A total of 92 patients with AIP were divided into an IgG4-RKD-positive group (RKD-P group, n = 13) and an IgG4-RKD-negative group (RKD-N group, n = 79) on the basis of the diagnostic criteria for IgG4-RKD. Clinical characteristics, including: age; sex; the presence of extrapancreatic lesions other than renal lesions, proteinuria, and hematuria; serum concentrations of IgG, IgG4, IgE, and creatinine; and urinary concentrations of liver-type fatty acid binding protein, α1-microglobulin, β2-microglobulin, and N-acetyl-β-d-glucosaminidase were compared between the RKD-P and RKD-N groups. Read More

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http://dx.doi.org/10.1016/j.advms.2018.12.005DOI Listing
February 2019
11 Reads

Exercise training program in patients with NYHA III class systolic heart failure - Parallel comparison to the effects of resynchronization therapy.

Adv Med Sci 2019 Feb 26;64(2):241-245. Epub 2019 Feb 26.

2nd Department of Coronary Artery Disease, Institute of Cardiology, Warsaw, Poland.

Purpose: The aim of this study was to assess exercise capacity and echocardiographic parameters in patients with heart failure with reduced ejection fraction (HFrEF) in NYHA III functional class, after cardiac resynchronization therapy (CRT) or implantable cardioverter-defibrillator (ICD) implantation followed by 6 months of supervised rehabilitation in ICD patients.

Materials And Methods: The study included patients with HFrEF and impaired left ventricle systolic function (LVEF ≤ 35%), divided into two groups: CRT group - patients after CRT-D implantation > six weeks, and ICD-rehab group - patients after ICD implantation > six weeks, followed by 6 months of supervised aerobic interval training and the conditioning exercises. At baseline and after 6 months in all the patients cardiopulmonary exercise tests (CPX) and standard echocardiographic examinations were performed. Read More

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http://dx.doi.org/10.1016/j.advms.2018.12.006DOI Listing
February 2019
5 Reads

Significance of BRCA1 expression in breast and ovarian cancer patients with brain metastasis - A multicentre study.

Adv Med Sci 2019 Feb 26;64(2):235-240. Epub 2019 Feb 26.

Department of Gynecology and Gynecologic Oncology, Medical University of Bialystok, Bialystok, Poland.

Purpose: Cerebral metastases develop in 10-30% of patients with breast cancer (BC) and in around 3.3 to 4% of patients with ovarian cancer (OC). The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), stromal cell-derived factor 1 (SDF1) and its receptor C-X-C chemokine receptor type 4 (CXCR4), breast cancer metastasis suppressor 1 (BRMS1), astrocyte elevated gene 1 (AEG1), depending on the status of BRCA1 protein, in patients suffering from OC and BC with brain metastases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18961126183015
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http://dx.doi.org/10.1016/j.advms.2018.12.007DOI Listing
February 2019
5 Reads

Analysis of chosen SNVs in GPC5, CD58 and IRF8 genes in multiple sclerosis patients.

Adv Med Sci 2019 Feb 25;64(2):230-234. Epub 2019 Feb 25.

Department of Neurology, Medical University in Bialystok, Bialystok, Poland.

Purpose: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system with a neurodegenerative compound. Heterogenetic background of autoimmunity pathway components has been suggested in the MS pathogenesis. The main aim of our study was to evaluate the association between selected polymorphisms of theCD58, IRF8 and GPC5 genes and treatment effectiveness in a group of relapsing-remitting MS patients. Read More

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http://dx.doi.org/10.1016/j.advms.2018.12.004DOI Listing
February 2019

Circadian clock genes and circadian phenotypes in patients with myocardial infarction.

Adv Med Sci 2019 Feb 25;64(2):224-229. Epub 2019 Feb 25.

Clinical Institute of Medical Genetics, University Medical Center Ljubljana, Ljubljana, Slovenia.

Purpose: Human physiological activities and diseases are under the control of the circadian rhythm. There are strong epidemiological associations between disrupted circadian rhythms, sleep duration and diseases. Sleep disorders are associated with vascular outcomes, such as myocardial infarction (MI). Read More

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http://dx.doi.org/10.1016/j.advms.2018.12.003DOI Listing
February 2019
3 Reads

Anti-angiogenic efficacy in invasive breast carcinoma patients depends on clinicopathological determinants.

Adv Med Sci 2019 Feb 25;64(2):216-223. Epub 2019 Feb 25.

Department of Pathophysiology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland. Electronic address:

Purpose: The biggest problem with the occurrence of breast cancer is late diagnosis, which is associated with high mortality rates. The aim of the study was to appraise the number of circulating endothelial precursors and the concentration of vascular endothelial growth factor A (VEGF-A) and the soluble forms of its receptors, sVEGFR1 and sVEGFR2, in breast cancer patients with respect to clinicopathological features.

Material And Methods: The study involved 85 women of Caucasian ethnicity aged 45-66 with primary breast cancer without distant metastases (M0). Read More

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http://dx.doi.org/10.1016/j.advms.2019.02.001DOI Listing
February 2019
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Hepcidin - Potential biomarker of contrast-induced acute kidney injury in patients undergoing percutaneous coronary interventions.

Adv Med Sci 2019 Feb 25;64(2):211-215. Epub 2019 Feb 25.

Department of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.

Purpose: Contrast-induced acute kidney injury (CI-AKI) is a common and potentially serious complication of percutaneous coronary interventions (PCI). In this study, we tested the hypothesis whether serum and urinary hepcidin could represent early biomarkers of CI-AKI in patients with normal serum creatinine undergoing PCI. In addition, we assessed serum and urinary neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, eGFR and serum creatinine in these patients. Read More

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http://dx.doi.org/10.1016/j.advms.2018.12.008DOI Listing
February 2019
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Influence of copper (I) nicotinate complex and autophagy modulation on doxorubicin-induced cytotoxicity in HCC1806 breast cancer cells.

Adv Med Sci 2019 Feb 22;64(1):202-209. Epub 2019 Feb 22.

Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt.

Purpose: Doxorubicin is regarded as the most therapeutic active agent available for triple-negative breast cancer (TNBC) treatment. However, the development of drug resistance and toxicity limits its effectiveness. Thus, developing novel strategies for TNBC treatment remains a significant challenge and doxorubicin-based combinations either by metal complexes (Copper I nicotinate complex) or with autophagy modulators could provide novel strategies and alternative strategies contributed to cancer cell death pathways, autophagy and apoptosis. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.014DOI Listing
February 2019
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Insulin-like growth factor-binding protein 7 (IGFBP 7) as a new biomarker in coronary heart disease.

Adv Med Sci 2019 Feb 12;64(1):195-201. Epub 2019 Feb 12.

Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.

Purpose: The role of insulin-like growth factor-binding protein-7 (IGFBP-7) in atherosclerosis is still not well-known. The objective of this study was to find out the following: 1) whether IGFBP-7 may act as a biomarker of coronary artery disease (CAD) occurrence and extent; 2) whether IGFBP-7 is potentially related to the classical and new markers of cardiovascular risk (carotid intima-media thickness - cIMT); 3) whether IGFBP-7 may be a marker of mortality in the group of patients with myocardial infarction (MI).

Materials/methods: The study group consisted of 212 patients with MI and 75 patients with stable CAD, the control group included 100 healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.017DOI Listing
February 2019
2 Reads

Urinary procollagen III aminoterminal propeptide and β-catenin - New diagnostic biomarkers in solitary functioning kidney?

Adv Med Sci 2019 Feb 6;64(1):189-194. Epub 2019 Feb 6.

Department of Pediatrics and Nephrology, Medical University of Bialystok, Poland.

Purpose: We aimed at evaluating urinary levels of procollagen III aminoterminal propeptide (PIIINP) and β-catenin and the relationship between these markers and clinical and laboratory variables in children with a solitary functioning kidney (SFK).

Patients And Methods: The study group consisted of 98 (M/F: 62/36) children with an SFK with a median age of 8 years. An age-matched control group contained 54 healthy peers. Read More

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http://dx.doi.org/10.1016/j.advms.2018.10.002DOI Listing
February 2019

Ensembling rules in automatic analysis of pressure on plantar surface in children with pes planovalgus.

Adv Med Sci 2019 Feb 1;64(1):181-188. Epub 2019 Feb 1.

2nd Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Bialystok, Poland.

Purpose: This paper presents a method of ensembling rules obtained through induction of several basic types of decision trees.

Material And Methods: The proposed method uses rules generated by means of well-known decision trees: CART, CHAID, exhaustive CHAID and C4.5. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.009DOI Listing
February 2019
2 Reads

Evaluation of the serum prooxidant-antioxidant balance before and after vitamin D supplementation in adolescent Iranian girls.

Adv Med Sci 2019 Jan 30;64(1):174-180. Epub 2019 Jan 30.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Purpose: Oxidative stress is caused by an imbalance between the antioxidant defenses and pro-oxidant production in favor of pro-oxidant production. Vitamin D has the potential for both pro- and anti-oxidative effects. The aim of this study was to assess the effect of high dose vitamin D supplementation on the prooxidant-antioxidant balance (PAB) in Iranian girls attending High School. Read More

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http://dx.doi.org/10.1016/j.advms.2018.10.004DOI Listing
January 2019

Serotonin transporter gene linked polymorphism (5-HTTLPR) determines progredience of alcohol dependence in Belarusian young males.

Adv Med Sci 2019 Jan 29;64(1):169-173. Epub 2019 Jan 29.

Department of Psychiatry, Medical University of Bialystok, Choroszcz, Poland. Electronic address:

Purpose: Allelic duality and functional impact of degenerate repeat at 5'- flanking promoter region in SLC6A4 gene of the serotonin transporter (5-HTTLPR), have been in the focus of investigations over the years. Various outcomes regarding an association of its polymorphism with risks of alcohol dependence syndrome (ADS) were presented. Such studies have not been conducted in the Eastern European population e. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.010DOI Listing
January 2019
1 Read

Comparison of left side or right side vagotomy in the rat subjected to acute pancreatitis.

Adv Med Sci 2019 Jan 25;64(1):162-168. Epub 2019 Jan 25.

Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland. Electronic address:

Purpose: We aimed to evaluate the effects of unilateral vagotomy (right-VR or left-VL) on the severity of caerulein-induced acute pancreatitis (AP).

Material And Methods: VR or VL was done in Wistar rats 4 days before AP, except in control, sham operated group. Following 5 h administration of subcutaneous injections of caerulein, the pancreatic blood flow (PBF), serum lipase and IL-10 in caval blood samples were measured. Read More

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http://dx.doi.org/10.1016/j.advms.2018.10.001DOI Listing
January 2019
1 Read

Personal mobile device-based pocket echocardiograph-The diagnostic value and clinical utility.

Adv Med Sci 2019 Jan 25;64(1):157-161. Epub 2019 Jan 25.

Department of Cardiology, Medical University of Lodz, Lodz, Poland.

Purpose: A microUSB ultrasound probe, which can be connected to a personal mobile device constitutes a new class of diagnostic pocket-size imaging devices (PSID). The aim of this study was to assess the feasibility and diagnostic value of brief transthoracic echocardiographic examination (bTTE) performed with the use of such equipment.

Material And Methods: The study population comprised 87 consecutive patients (58 men, mean age 61 ± 16 years), 53 of whom were admitted to intensive cardiac care unit and 34 patients, who were referred for transthoracic echocardiography from outpatient clinic. Read More

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http://dx.doi.org/10.1016/j.advms.2018.11.003DOI Listing
January 2019
2 Reads

An endoscopic training and assessment model for argon plasma coagulation.

Adv Med Sci 2019 Jan 19;64(1):152-156. Epub 2019 Jan 19.

Gastroenterology Division, Department of Internal Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA.

Purpose: Argon plasma coagulation (APC) is a standard modality for the treatment of gastrointestinal bleeding. However, there are no metrics to assess technical proficiency. We aimed to determine if a Quick APC Training Test (QAPCTT) can improve performance and assess proficiency with this modality. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.012DOI Listing
January 2019
7 Reads

Pleiotrophin: Analysis of the endothelialisation potential.

Adv Med Sci 2019 Jan 17;64(1):144-151. Epub 2019 Jan 17.

Laboratory of Human Anatomy, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. Electronic address:

Purpose: Endothelialisation of vascular substitutes, in fact, remains one of the most unsolved problems in cardiovascular diseases treatment. Stromal Derived Factor 1 (SDF-1) has been largely investigated as an endothelialisation promoter and Pleiotrophin is a promising alternative. Although it has been known to exert beneficial effects on different cell types, its potential as an inducer of proliferation and migration of endothelial cells was not investigated. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.007DOI Listing
January 2019
4 Reads

Association of 18bp insertion/deletion polymorphism, at -2549 position of VEGF gene, with diabetic vascular complications in type 2 diabetes mellitus.

Adv Med Sci 2019 Jan 15;64(1):137-143. Epub 2019 Jan 15.

Department of Genetics, Chair of Molecular Medicine, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland; Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland.

Purpose: Diabetes mellitus type 2 (T2DM) and its vascular complications are a serious world health problem. For this reason it is important to look for new diabetes complication risk factors. The aim of this study was to determine whether 18-bp insertion/deletion (I/D) polymorphism at -2549 position of the vascular endothelial growth factor (VEGF) gene is associated with diabetic vascular complications (DVC). Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.011DOI Listing
January 2019
18 Reads

Cardiac troponins in chronic kidney disease patients with special emphasis on their importance in acute coronary syndrome.

Adv Med Sci 2019 Jan 12;64(1):131-136. Epub 2019 Jan 12.

1st Department of Nephrology and Transplantation with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.

Troponin measurement is one of crucial assessments facilitating diagnosis of acute coronary syndrome. Patients with chronic kidney disease are decimated by cardiovascular disease. Unfortunately, elevated concentration of serum troponin is commonly faced in clinical practice creating a challenge to rule out acute cardiac ischaemia in this vulnerable population. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.016DOI Listing
January 2019
1 Read

Mast cells in mastocytosis and allergy - Important player in metabolic and immunological homeostasis.

Adv Med Sci 2019 Jan 11;64(1):124-130. Epub 2019 Jan 11.

Department of General and Medical Biochemistry, University of Gdańsk, Gdańsk, Poland.

The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell mediators, especially those released from mast cells in degranulation, but also those released constitutively, are important both in metabolic and immunological processes. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.013DOI Listing
January 2019
8 Reads

Combination therapy profoundly improved skin flap survival by modulating KATP channels and nitric oxide.

Adv Med Sci 2019 Jan 10;64(1):117-123. Epub 2019 Jan 10.

Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: A potential therapeutic approach on skin flap necrosis is to target parallel pathways involved in necrosis. Azelaic Acid, Minoxidil and Caffeine combination was tried on skin flap survival by their possible interaction with ATP sensitive potassium (KATP) channels and nitric oxide pathway.

Material And Methods: Sprauge-Dawley rats were divided into 8 groups for skin flap surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18961126183034
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http://dx.doi.org/10.1016/j.advms.2018.08.015DOI Listing
January 2019
7 Reads

The concentration-dependent effect of anethole on collagen, MMP-2 and GAG in human skin fibroblast cultures.

Adv Med Sci 2019 Jan 10;64(1):111-116. Epub 2019 Jan 10.

Department of Medical Chemistry, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Purpose: In aging skin and some skin disorders, components of skin extracellular matrix (ECM) are disturbed and therefore research to find skin drugs is important. Evaluation of anethole impact on collagen, GAGs and MMP-2 in human skin fibroblasts was the aim of this study.

Materials And Methods: For collagen assay the Sircol dye, 5-[H]proline and real time-PCR were used. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.008DOI Listing
January 2019
13 Reads

Metabolic pathways of L-arginine and therapeutic consequences in tumors.

Adv Med Sci 2018 Dec 31;64(1):104-110. Epub 2018 Dec 31.

Department of Propaedeutics of Oncology, Medical University of Gdansk, Gdansk, Poland; Department of Oncological Surgery, Gdynia Oncology Centre, Gdynia, Poland.

Difference in the metabolism of normal and cancer cells inspires to search for new, more specific and less toxic therapies than those currently used. The development of tumors is conditioned by genetic changes in cancer-transformed cells, immunological tolerance and immunosuppression. At the initial stages of carcinogenesis, the immune system shows anti-tumor activity, however later, cancer disrupts the function of Th1/Th17/Th2 lymphocytes by regulatory T (Treg) cells, tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) and finally causes immunosuppression. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.018DOI Listing
December 2018
17 Reads
0.964 Impact Factor

Twenty years of growth hormone treatment in dialyzed children in Poland-Results of national multicenter study.

Adv Med Sci 2018 Dec 20;64(1):90-99. Epub 2018 Dec 20.

Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

Purpose: The aim of the study was to analyze the effect of recombinant human growth hormone (rhGH) therapy and to establish factors influencing growth rate in dialyzed children in Poland.

Methods: We retrospectively analyzed medical records of 81 children with end-stage renal disease (ESRD) on chronic dialysis treated with rhGH for ≥12 months between 1994 and 2014. The following data were recorded: cause of ESRD, dialysis modality, age at the dialysis and rhGH initiation [years]. Read More

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http://dx.doi.org/10.1016/j.advms.2018.12.001DOI Listing
December 2018
2 Reads

The implantation of the scleral-fixated posterior chamber intraocular lens with 9/0 polypropylene sutures - Long-term visual outcomes and complications.

Adv Med Sci 2018 Dec 21;64(1):100-103. Epub 2018 Dec 21.

Department of Ophthalmology, The Medical University of Bialystok Clinical Hospital, Bialystok, Poland.

Purpose: To analyze long-term visual outcomes and complications of the implantation of a scleralfixated posterior chamber intraocular lens (PC-IOL) in patients with the lack of adequate capsular support, and to verify if the procedure can be performed with 9-0 polypropylene sutures.

Methods: The study was designed as a long-term retrospective analysis. Patients after the implantation of a scleralfixated PC-IOL were evaluated for the best corrected visual acuity (BCVA), intraocular pressure and occurrence of postoperative complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18961126183033
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http://dx.doi.org/10.1016/j.advms.2018.08.005DOI Listing
December 2018
11 Reads

Serum levels and gene expression of pentraxin 3 are elevated in COPD.

Adv Med Sci 2018 Dec 17;64(1):85-89. Epub 2018 Dec 17.

Department of General and Oncological Pulmonology, First Chair of Internal Diseases, Medical University of Lodz, Lodz, Poland.

Purpose: Pentraxin 3 (PTX-3) is an acute phase protein that belongs to the pentraxin superfamily. It is synthesized locally at the site of inflammation and its levels are related to the damage of blood vessels. There are only a few studies examining the relationship between PTX-3 and chronic obstructive pulmonary disease (COPD). Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.006DOI Listing
December 2018
16 Reads

DNA variants in Helicobacter pylori infected patients with chronic gastritis, dysplasia and gastric cancer.

Adv Med Sci 2018 Dec 13;64(1):79-84. Epub 2018 Dec 13.

Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Poznan, Poland; Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland. Electronic address:

Purpose: The main scope of this study was to evaluate the importance of selected DNA variants for developing inflammation of gastric mucosa and carcinogenesis in gastrointestinal diseases in patients infected with Helicobacter pylori.

Patients And Methods: Patients subjected to analysis constituted a group of 131 consecutive cases, with control groups consisting of 100 healthy volunteers and 13 dyspeptic patients. Molecular analysis included the following genes: TP53 (c. Read More

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http://dx.doi.org/10.1016/j.advms.2018.12.002DOI Listing
December 2018

16 α-Hydroxyestrone induced adduct generate high affinity autoantibodies in SLE.

Authors:
Wahid Ali Khan

Adv Med Sci 2018 Dec 5;64(1):72-78. Epub 2018 Dec 5.

Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia. Electronic address:

Purpose: Increased 16 α-hydroxyestrone (16 α-OHE) and autoantibodies against histone H1 (H) have been well described in systemic lupus erythematosus (SLE), but the combination effects of 16 α-OHE and H remains unclear. Here, we tried to assess the affinity and binding specificity of SLE autoantibodies against the 16 α-OHE-H adduct. IgG was induced against this adduct and was also used as immunochemical probe for the estimation of 16 α-OHE in the serum of SLE patients. Read More

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http://dx.doi.org/10.1016/j.advms.2018.11.002DOI Listing
December 2018
0.964 Impact Factor

Beneficial effect of ovocystatin on the cognitive decline in APP/PS1 transgenic mice.

Adv Med Sci 2018 Nov 30;64(1):65-71. Epub 2018 Nov 30.

Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland.

Purpose: Cystatin C plays an important role in the course of neurodegenerative diseases and has a beneficial effect through inhibiting cysteine proteases and amyloid-β aggregation. It also induces proliferation and autophagy. Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.002DOI Listing
November 2018

Epilepsy identification based on EEG signal using RQA method.

Adv Med Sci 2018 Nov 23;64(1):58-64. Epub 2018 Nov 23.

Faculty of Mechanical Engineering, Bialystok University of Technology, Bialystok, Poland.

Purpose: Epilepsy is one of the most common neurological diseases and its cause is not unequivocal. Thus, additional methods and searches that may help to diagnose the disease are used in the clinical practice. In this study, we tested the possibility of using the Recurrence Quantification Analysis (RQA) method to identify epilepsy and present the analysis of EEG signals of healthy patients and epileptic patients by the RQA method. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.003DOI Listing
November 2018
14 Reads

Effect of Lactobacillus acidophilus and Porphyromonas gingivalis on proliferation and apoptosis of gingival epithelial cells.

Adv Med Sci 2018 Nov 22;64(1):54-57. Epub 2018 Nov 22.

National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, China; Department of Preventive and Pediatric Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, China. Electronic address:

Purpose: This study aimed to evaluate the possible antagonistic effects of Lactobacillus acidophilus on Porphyromonas gingivalis, and detect inhibition of Lactobacillus acidophilus on Porphyromonas gingivalis when they are co-cultured with human gingival epithelial cells.

Materials And Methods: Human gingival epithelial cells were co-cultured with Lactobacillus acidophilus and Porphyromonas gingivalis alone or together. The amount of Porphyromonas gingivalis adhering to or invading the epithelial cells were determined by bacterial counts. Read More

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http://dx.doi.org/10.1016/j.advms.2018.04.008DOI Listing
November 2018
11 Reads
0.964 Impact Factor

Association between gastric myoelectric activity disturbances and dyspeptic symptoms in gastrointestinal cancer patients.

Adv Med Sci 2018 Nov 21;64(1):44-53. Epub 2018 Nov 21.

Department of Pathophysiology, Jagiellonian University Medical College, Cracow, Poland.

Purpose: Dyspeptic symptoms present a severe problem in gastrointestinal (GI) cancer patients. The aim of the study was to analyze an association between gastric myoelectric activity changes and dyspeptic symptoms in gastrointestinal cancer patients.

Material And Methods: The study included 80 patients (37 men and 43 women, mean age 61. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.004DOI Listing
November 2018
1 Read
0.964 Impact Factor

Fluid therapy in non-septic, refractory acute decompensated heart failure patients - The cautious role of central venous pressure.

Adv Med Sci 2018 Nov 14;64(1):37-43. Epub 2018 Nov 14.

Department of Cardiology, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Purpose: Fluid therapy in congestive acute decompensated heart failure (ADHF) patients might be inappropriate and worsening the prognosis. The aim of our study was to analyze the effect of fluid administration on mortality in non-septic, ADHF patients with reduced ejection fraction.

Material And Methods: We analyzed 41 ADHF consecutive 'cold-wet' patients (mean age 69. Read More

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http://dx.doi.org/10.1016/j.advms.2018.11.001DOI Listing
November 2018

Hypertension prevalence in early breast cancer patients undergoing primary surgery.

Adv Med Sci 2018 Nov 9;64(1):32-36. Epub 2018 Nov 9.

2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland; Department of Nephrology, Dialysis and Internal Medicine, Warsaw Medical University, Warsaw, Poland. Electronic address:

Purpose: Treatment with chemotherapy and targeted drugs may results in elevated risk of cardiac and renal toxicity as well as hypertension. However, data on prevalence of chronic kidney disease and hypertension in subjects with early breast cancer undergoing primary surgery are very limited.

Patients And Methods: The study aimed to assess the prevalence of chronic kidney disease and hypertension (evaluated as a preoperative assessment and defined according to ESC/ESH guidelines) in a cohort of 100 consecutive female patients with early breast cancer treated with primary surgery with curative intent. Read More

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http://dx.doi.org/10.1016/j.advms.2018.10.003DOI Listing
November 2018
1 Read

Activity of lysosomal exoglycosidases in the urine of healthy normotensive and pre-hypertensive children.

Adv Med Sci 2018 Oct 9;64(1):24-31. Epub 2018 Oct 9.

Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland.

Purpose: We investigated the relationship between blood pressure (BP) and the activity of lysosomal exoglycosidases: N-acetyl-β-hexosaminidase (HEX), its isoenzymes A (HEX A) and B (HEX B), α-fucosidase (FUC), β-galactosidase (GAL), β-glucuronidase (GLU) and α-mannosidase (MAN) in pre-hypertensive (high normal blood pressure - HNBP) and normal blood pressure (NBP) children.

Material And Methods: The study was carried out with urine samples collected from 176 children, aged 6-17.9 years, divided into 2 groups: 42 HNBP and 134 NBP subjects. Read More

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http://dx.doi.org/10.1016/j.advms.2018.09.001DOI Listing
October 2018
10 Reads

Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism.

Adv Med Sci 2018 Sep 19;64(1):15-23. Epub 2018 Sep 19.

Department of Analytical Chemistry, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Purpose: The effect of chronic administration of [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate (URB597), inhibitor of fatty acid amide hydrolase (FAAH) that hydrolyzes anandamide, on cross-talk between endocannabinoid system, oxidative status and pro-inflammatory factors in the liver of spontaneously hypertensive rats (SHRs) was investigated.

Materials/methods: Experiments were conducted using SHRs and normotensive control Wistar-Kyoto rats treated by intraperitoneal injection with URB597 for 14 days. The biochemical parameters were assayed in the rat's livers. Read More

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http://dx.doi.org/10.1016/j.advms.2018.06.002DOI Listing
September 2018
2 Reads

The combination of fecal calprotectin with ESR, CRP and albumin discriminates more accurately children with Crohn's disease.

Adv Med Sci 2018 Sep 18;64(1):9-14. Epub 2018 Sep 18.

Department of Pediatrics, Gastroenterology and Allergology, Medical University of Bialystok, Bialystok, Poland.

Purpose: Increased fecal calprotectin is a sensitive marker of various types of intestinal inflammation. We investigated correlations between high fecal calprotectin concentration and serum inflammatory markers in children with different intestinal diseases with diarrhea with/without blood and/or abdominal pain, to test whether the combination of these markers can differentiate potential patients with inflammatory bowel disease.

Materials/methods: The study included 128 children with high fecal calprotectin concentration (>150ug/g) and symptoms suggesting bowel disorders, hospitalized in the years 2013- 2015. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.001DOI Listing
September 2018
24 Reads

Diagnostic power of VEGF, MMP-9 and TIMP-1 in patients with breast cancer. A multivariate statistical analysis with ROC curve.

Adv Med Sci 2018 Sep 15;64(1):1-8. Epub 2018 Sep 15.

Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.

Purpose: Vascular endothelial growth factor is an important factor in promoting angiogenesis in malignant processes, matrix metalloproteinase-9 in the degradation of extracellular matrix, which enhances metastasis, and tissue inhibitor of metalloproteinase-1 is its inhibitor. The aim of this study was to investigate the diagnostic power of these parameters in comparison to CA15-3 in breast cancer patients and in relation to the control group.

Materials/methods: The study included 120 breast cancer patients, 60 patients with benign breast tumors and 60 healthy women. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18961126183027
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http://dx.doi.org/10.1016/j.advms.2018.07.002DOI Listing
September 2018
7 Reads

TiC-composite materials in applications for kinematic denture connections.

Adv Med Sci 2018 Sep 20;63(2):374-381. Epub 2018 Aug 20.

Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Bialystok, Poland.

Purpose: This paper presents an own proposal for the construction of a ball latch intended for use in prosthetic dentistry. Attention was paid to the existing commercial constructions of elements of the same type, indicating their advantages and disadvantages. Based on the analysis of the present solutions, own ones were proposed. Read More

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http://dx.doi.org/10.1016/j.advms.2018.04.012DOI Listing
September 2018
1 Read