85 results match your criteria Advances In Materials Science And Engineering[Journal]


Plant-mediated synthesis of dual-functional Eggshell/Ag nanocomposites towards catalysis and antibacterial applications.

Mater Sci Eng C Mater Biol Appl 2020 Aug 24;113:111015. Epub 2020 Apr 24.

College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou 362000, Fujian Province, PR China. Electronic address:

Advances in nanotechnology provide plenty of exciting solutions to environmental issues affecting air, soil as well as water. To solve the water pollution problem caused by organics and microorganisms, development of a simple, environment-friendly, and cheap method for the synthesis of nanomaterials is of paramount importance. Herein, we prepared a novel nanocomposite (named Eggshell/Ag) using waste eggshell as a support and Cacumen platycladi extract as reducing and stabilizing agents in aqueous solutions at room temperature. Read More

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http://dx.doi.org/10.1016/j.msec.2020.111015DOI Listing

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents.

Mater Sci Eng C Mater Biol Appl 2020 Jul 6;112:110924. Epub 2020 Apr 6.

State Key Laboratory of Agricultural Microbiology, College of Science, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address:

Research on highly effective antiviral drugs is essential for preventing the spread of infections and reducing losses. Recently, many functional nanoparticles have been shown to possess remarkable antiviral ability, such as quantum dots, gold and silver nanoparticles, nanoclusters, carbon dots, graphene oxide, silicon materials, polymers and dendrimers. Despite their difference in antiviral mechanism and inhibition efficacy, these functional nanoparticles-based structures have unique features as potential antiviral candidates. Read More

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http://dx.doi.org/10.1016/j.msec.2020.110924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195146PMC

MoS quantum dots: synthesis, properties and biological applications.

Mater Sci Eng C Mater Biol Appl 2020 Apr 2;109:110511. Epub 2019 Dec 2.

Department of Chemistry, University of Turku, Vatselankatu 2, Turku 20014, Finland. Electronic address:

Fluorescent nanomaterials have gained momentum due to their specific properties and promising applications in various fields. Molybdenum disulfide quantum dots (MoS QDs) are emerging as a new class of fluorescent nanomaterials that have generated tremendous research interests due to their unique optical properties and good biocompatibility. In this review, we firstly present an overview of the significant advances of MoS QDs in synthetic strategies including top-down and bottom-up approaches, followed by discussing their distinctive properties. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110511DOI Listing

Design of new protein drug delivery system (PDDS) with photoactive compounds as a potential application in the treatment of glioblastoma brain cancer.

Mater Sci Eng C Mater Biol Appl 2020 May 7;110:110638. Epub 2020 Jan 7.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Science and Letters of Ribeirão Preto, University of São Paulo (USP), 14040-901 Ribeirão Preto, SP, Brazil. Electronic address:

Glioblastoma multiforme (GBM) is an extremely aggressive malignant brain tumor. Despite advances in treatment modalities, it remains largely incurable. This unfavorable prognosis for GBM is at least partly due to the lack of a successful drug delivery system across the blood-brain barrier (BBB). Read More

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http://dx.doi.org/10.1016/j.msec.2020.110638DOI Listing

Recent progress in the fabrication techniques of 3D scaffolds for tissue engineering.

Mater Sci Eng C Mater Biol Appl 2020 May 3;110:110716. Epub 2020 Feb 3.

Department of Chemical Engineering, Loughborough University, Loughborough LE113TU, Leicestershire, UK.

Significant advances have been made in the field of tissue engineering (TE), especially in the synthesis of three-dimensional (3D) scaffolds for replacing damaged tissues and organs in laboratory conditions. However, the gaps in knowledge in exploiting these techniques in preclinical trials and beyond and, in particular, in practical scenarios (e.g. Read More

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http://dx.doi.org/10.1016/j.msec.2020.110716DOI Listing

Advances in cartilage repair: The influence of inorganic clays to improve mechanical and healing properties of antibacterial Gellan gum-Manuka honey hydrogels.

Mater Sci Eng C Mater Biol Appl 2020 Mar 18;108:110444. Epub 2019 Nov 18.

Department of Chemistry, University of Bari "Aldo Moro", via E. Orabona 4, Bari 70126, Italy. Electronic address:

Effective treatment of cartilage defects represents a challenging problem, mainly due to the tissue's limited intrinsic self-repair capacity; the use of polymeric scaffolds as tissue substitute is rapidly increasing, but it is still limited by poor mechanical properties. Moreover, the onset of an infection can irreversibly affect the healing process. Accordingly, in this work we describe, for the first time, the preparation of composite scaffolds based on gellan gum, antibacterial Manuka honey and an inorganic clay (mesoporous silica, sodium‑calcium bentonite or halloysite nanotubes). Read More

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http://dx.doi.org/10.1016/j.msec.2019.110444DOI Listing

Electrospun silk nanofibers improve differentiation potential of human induced pluripotent stem cells to insulin producing cells.

Mater Sci Eng C Mater Biol Appl 2020 Mar 5;108:110398. Epub 2019 Nov 5.

Department of Biotechnology, School of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran; Dietary Supplements and Probiotic Center, Alborz University of Medical Sciences, Karaj, Iran.

With regard to lifestyle and diet, one of the problems that threaten mankind is diabetes. Given the lack of responsiveness to available drug therapies, the advances made in recent decades in tissue engineering and cell therapy have created a great deal of hope for the treatment of this disease. In this study, silk nanofibrous scaffold (3D) was fabricated by electrospinning and then its biocompatibility and non-toxicity by MTT assay. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110398DOI Listing
March 2020
3.088 Impact Factor

Scaffold strategies for modulating immune microenvironment during bone regeneration.

Mater Sci Eng C Mater Biol Appl 2020 Mar 9;108:110411. Epub 2019 Nov 9.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, PR China; Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, Chongqing 400044, PR China. Electronic address:

Implanted bone scaffolds often fail to successfully integrate with the host tissue because they do not elicit a favorable immune reaction. Properties of bone scaffold not only provide mechanical and chemical signals to support cell adhesion, migration, proliferation and differentiation, but also play a pivotal role in determining the extent of immune response during bone regeneration. Appropriate design parameters of bone scaffold are of great significance in the process of developing a new generation of bone implants. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110411DOI Listing
March 2020
3.088 Impact Factor

Recent advances in the application of mesoporous silica-based nanomaterials for bone tissue engineering.

Mater Sci Eng C Mater Biol Appl 2020 Feb 15;107:110267. Epub 2019 Oct 15.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA, 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, 02139, USA. Electronic address:

Silica nanomaterials (SNMs) and their composites have recently been investigated as scaffolds for bone tissue engineering. SNM scaffolds possess the ability to encourage bone cell growth and also allow the simultaneous delivery of biologically active biomolecules that are encapsulated in the mesopores. Their high mechanical strength, low cytotoxicity, ability to stimulate both the proliferation and osteogenic differentiation of progenitor cells make the SNMs appropriate scaffolds. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907012PMC
February 2020
3.088 Impact Factor

Folate-conjugated nanovehicles: Strategies for cancer therapy.

Mater Sci Eng C Mater Biol Appl 2020 Feb 23;107:110341. Epub 2019 Oct 23.

Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, 04620, Republic of Korea. Electronic address:

Cancer theranostics represents a strategy that aims at combining diagnosis with therapy through the simultaneous imaging and targeted delivery of therapeutics to cancer cells. Recently, the folate receptor alpha has emerged as an attractive theranostic target due to its overexpression in multiple solid tumors and its great functional versatility. In fact, it can be incorporated into folate-conjugated nano-systems for imaging and drug delivery. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110341DOI Listing
February 2020
50 Reads
3.088 Impact Factor

Spinel ferrite nanoparticles and nanocomposites for biomedical applications and their toxicity.

Mater Sci Eng C Mater Biol Appl 2020 Feb 23;107:110314. Epub 2019 Oct 23.

Nanotechnology and Water Sustainability Research Unit, College of Science, Engineering and Technology, University of South Africa, Florida Science Campus, 1710, South Africa; State Key Laboratory of Separation Membranes and Membrane Processes, National Centre for International Joint Research on Membrane Science and Technology, Tianjin, 300387, PR China. Electronic address:

This review focuses on the biomedical applications and toxicity of spinel ferrite nanoparticles (SFNPs) with more emphasis on the recently published work. A critical review is provided on recent advances of SFNPs applications in biomedical areas. The novelty of SFNPs in addressing the bottleneck problems encountered in the areas of health; in particular, for diagnosis and treatment of tumour cells are well reviewed. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110314DOI Listing
February 2020

Prosthodontics dental materials: From conventional to unconventional.

Mater Sci Eng C Mater Biol Appl 2020 Jan 7;106:110167. Epub 2019 Sep 7.

Department of Chemistry, COMSATS University Islamabad, Lahore Campus, Lahore 54600, Pakistan.

New inventions and innovations in the field of dentistry have potential applications to satisfy the patient's demand. In prosthodontics, a dental prosthesis plays a major role in improving the quality of oral health care. Currently, the trends have shifted towards the implants and implant-supported prosthesis for the replacement of missing teeth. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110167DOI Listing
January 2020
3.088 Impact Factor

Advanced nanoscale carrier-based approaches to overcome biopharmaceutical issues associated with anticancer drug 'Etoposide'.

Mater Sci Eng C Mater Biol Appl 2020 Jan 11;106:110275. Epub 2019 Oct 11.

National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Opposite Air Force Station Palaj, Gandhinagar, Gujarat, 382355, India; Department of Materials Engineering, Indian Institute of Technology (IIT) -Jammu, Jagti, PO Nagrota, Jammu, 181 221, J&K, India. Electronic address:

Etoposide (ETS), topoisomerase-II inhibitor, is a first-line anticancer therapeutics used in diverse cancer types. However, the therapeutic potential of this molecule has mainly impeded due to its detrimental toxicity profile, unfavorable rejection by the cancer cells due to P-glycoprotein (P-gp) efflux activity, and rapid hepatic clearance through extensive metabolism by Cytochrome-P450. To increase the therapeutic potency without significant adverse effects, the implication of novel ETS-nanoformulation strategies have recommended mainly. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110275DOI Listing
January 2020
3.088 Impact Factor

Nanotechnology-based biomaterials for orthopaedic applications: Recent advances and future prospects.

Mater Sci Eng C Mater Biol Appl 2020 Jan 2;106:110154. Epub 2019 Sep 2.

Department of Civil & Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul 04763, Republic of Korea. Electronic address:

Bioimplant engineering aims to mature biological alternatives to restore, retain, or modify damaged tissues and/or the functionality of organs. Remarkable advancements in modern material technology have helped the diversity of materials for orthopaedic implant application. As such, nanomaterials can simulate the surface properties of natural tissues, especially with respect to surface topography, surface chemistry, surface energy, and surface wettability. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110154DOI Listing
January 2020
3.088 Impact Factor

Magnetic, fluorescent and hybrid nanoparticles: From synthesis to application in biosystems.

Mater Sci Eng C Mater Biol Appl 2020 Jan 31;106:110104. Epub 2019 Aug 31.

BIOSCOPE Group, LAQV@REQUIMTE, Nova School of Science and Technology, NOVA University Lisbon, Caparica Campus, 2829-516 Caparica, Portugal; PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Caparica, Portugal. Electronic address:

Multifunctional nanoparticles have emerged as an outstanding candidate for a new generation of biomedical applications, mainly due to their remarkable properties and biocompatibility. Individual reports on multi-metal, semiconducting and superparamagnetic nanoparticles (SPIONs), elucidating on each's unique intrinsic properties, have demonstrated that the biological application of such materials is highly dependent of their size, shape, surface nature and core nature. However, reviews combining nanoparticles with multiple properties, as fluorescence and paramagnetism, as well as, biocompatibility, toxicology and biodegradability are yet seldom. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110104DOI Listing
January 2020

Nanoharvesting of bioactive materials from living plant cultures using engineered silica nanoparticles.

Mater Sci Eng C Mater Biol Appl 2020 Jan 11;106:110190. Epub 2019 Sep 11.

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA. Electronic address:

Plant secondary metabolites are valuable therapeutics not readily synthesized by traditional chemistry techniques. Although their enrichment in plant cell cultures is possible following advances in biotechnology, conventional methods of recovery are destructive to the tissues. Nanoharvesting, in which nanoparticles are designed to bind and carry biomolecules out of living cells, offers continuous production of metabolites from plant cultures. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935263PMC
January 2020

Sonication-assisted Layer-by-Layer self-assembly nanoparticles for resveratrol delivery.

Mater Sci Eng C Mater Biol Appl 2019 Dec 29;105:110022. Epub 2019 Jul 29.

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

This paper advances the development of a novel drug nanodelivery solution to the oral administration of resveratrol (RSV), a low soluble drug whose recognized therapeutic applications are circumscribed when administered in the free compound form. Layer-by-Layer (LbL) self-assembly is an emergent nanotechnology proposed to address this concern with means to afford control over key formulation parameters, which are able to ultimately promote an improved pharmacokinetics. LbL self-assembly consists in the sequential adsorption of oppositely charged polyelectrolytes upon a low soluble drug nanoparticle (NP) template, giving rise to onion-like multilayered nanoarchitectures. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110022DOI Listing
December 2019
1 Read

Mechanical properties of bioactive glasses, ceramics, glass-ceramics and composites: State-of-the-art review and future challenges.

Mater Sci Eng C Mater Biol Appl 2019 Nov 16;104:109895. Epub 2019 Jun 16.

School of Engineering, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

The repair and restoration of bone defects in orthopaedic and dental surgery remains a major challenge despite advances in surgical procedures and post-operative treatments. Bioactive glasses, ceramics, glass-ceramics and composites show considerable potential for such applications as they can promote bone tissue regeneration. This paper presents an overview of the mechanical properties of various bioactive materials, which have the potential for bone regeneration. Read More

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http://dx.doi.org/10.1016/j.msec.2019.109895DOI Listing
November 2019
6 Reads

Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review.

Mater Sci Eng C Mater Biol Appl 2019 Nov 15;104:109891. Epub 2019 Jun 15.

State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, 100029 Beijing, China. Electronic address:

Currently, a lot of efforts have been applied to diagnosis and treat tumors through the fabrication of highly-efficient and multi-functional nanomaterials. Superior to other methods, photothermal therapy (PTT) has been demonstrated as a noninvasive, controllable, and targeted strategy to eliminate tumor cells. The use of functional biomedical and bioactive nanomaterials can enhance the photothermal performances and meanwhile integrate with favorable functions, by taking into account their risk assessments. Read More

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http://dx.doi.org/10.1016/j.msec.2019.109891DOI Listing
November 2019

Recent advances on nanomaterials-based fluorimetric approaches for microRNAs detection.

Mater Sci Eng C Mater Biol Appl 2019 Nov 19;104:110007. Epub 2019 Jul 19.

Cellular and Molecular Research Center, Research Institute for Cellular and Molecular Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

MicroRNAs are types of small single-stranded endogenous highly conserved non-coding RNAs, which play main regulatory functions in a wide range of cellular and physiological events, such as proliferation, differentiation, neoplastic transformation, and cell regeneration. Recent findings have proved a close association between microRNAs expression and the development of many diseases, indicating the importance of microRNAs as clinical biomarkers and targets for drug discovery. However, due to a number of prominent characteristics like small size, high sequence similarity and low abundance, sensitive and selective identification of microRNAs has rather been a hardship through routine traditional assays, including quantitative polymerase chain reaction, microarrays, and northern blotting analysis. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110007DOI Listing
November 2019
1 Read

Recent development and biomedical applications of decellularized extracellular matrix biomaterials.

Mater Sci Eng C Mater Biol Appl 2019 Nov 3;104:109942. Epub 2019 Jul 3.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address:

Decellularized matrix (dECM) is isolated extracellular matrix of tissues from its original inhabiting cells, which has emerged as a promising natural biomaterial for tissue engineering, aiming at support, replacement or regeneration of damaged tissues. The dECM can be easily obtained from tissues/organs of various species by adequate decellularization methods, and mimics the structure and composition of the native extracellular matrix, providing a favorable cellular environment. In this review, we summarize the recent developments in the preparation of dECM materials, including decellularization, crosslinking and sterilization. Read More

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http://dx.doi.org/10.1016/j.msec.2019.109942DOI Listing
November 2019
3 Reads

Facile synthesized novel hybrid graphene oxide/cobalt ferrite magnetic nanoparticles based surface coating material inhibit bacterial secretion pathway for antibacterial effect.

Mater Sci Eng C Mater Biol Appl 2019 Nov 2;104:109932. Epub 2019 Jul 2.

Institute of Physics, Bhubaneswar 751 005, India.

Nanomaterial based paints are in current demand in the area of surface protective coatings due to the significant advances made to improve their antibacterial and anticorrosion characteristics. In this work, we have developed magnetic graphene oxide (MGO) paint with the incorporation of cobalt ferrite (CF) and graphene oxide (GO) along with paint materials by using high energy ball milling (HEBM). Morphological, elemental and functional analysis of the MGO paint is studied with ESEM, AFM, Raman, FTIR spectroscopy. Read More

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http://dx.doi.org/10.1016/j.msec.2019.109932DOI Listing
November 2019
3.088 Impact Factor

Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies.

Mater Sci Eng C Mater Biol Appl 2019 Oct 3;103:109717. Epub 2019 May 3.

NMIMS, School of Pharmacy and Technology Management, Shirpur, Maharashtra, India. Electronic address:

In the twenty-first century, microneedles based drug delivery is drawing attention worldwide in the research due to current signs of progress in the controlled release drug delivery through microneedles. The microneedles represent a promising technology to deliver therapeutic compounds into the skin for chronic complications like osteoporosis, diabetes, cancer and induction of immune responses from protein and DNA vaccines. However, the delivery of hydrophilic drugs and macromolecular agents are challenging. Read More

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http://dx.doi.org/10.1016/j.msec.2019.05.002DOI Listing
October 2019
3.088 Impact Factor

Thermo-responsive polymers: Applications of smart materials in drug delivery and tissue engineering.

Mater Sci Eng C Mater Biol Appl 2019 Sep 24;102:589-605. Epub 2019 Apr 24.

Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy.

Synthetic polymers are attracting great attention in the last decades for their use in the biomedical field as nanovectors for controlled drug delivery, hydrogels and scaffolds enabling cell growth. Among them, polymers able to respond to environmental stimuli have been recently under growing consideration to impart a "smart" behavior to the final product, which is highly desirable to provide it with a specific dynamic and an advanced function. In particular, thermo-responsive polymers, materials able to undergo a discontinuous phase transition or morphological change in response to a temperature variation, are among the most studied. Read More

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http://dx.doi.org/10.1016/j.msec.2019.04.069DOI Listing
September 2019
2 Reads

Supramolecular-based nanofibers.

Mater Sci Eng C Mater Biol Appl 2019 Aug 9;101:650-659. Epub 2019 Apr 9.

State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China. Electronic address:

Supramolecular-based nanofibers, which successfully combine the unique properties of supramolecular interactions with the advantages of nanofibrous structure, are widely used in a variety of biomedical applications such as controlled drug delivery. Compared with traditional polymer nanofibers, supramolecular-based nanofibers can overcome the bottleneck of sensitivity because of the non-covalent binding modes, and therefore match the requirements of rapid and reversible response to the external stimuli. In addition, supramolecular-based nanofibers can achieve extra controllable and dynamic responsive (e. Read More

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http://dx.doi.org/10.1016/j.msec.2019.04.021DOI Listing
August 2019
5 Reads

Advances in additive manufacturing for bone tissue engineering scaffolds.

Mater Sci Eng C Mater Biol Appl 2019 Jul 13;100:631-644. Epub 2019 Mar 13.

CONICET, National Scientific and Technical Research Council, Argentina; LAMEIN, Faculty of Exact Sciences and Engineering, National University of Tucuman, Argentina.

This article reviews the current state of the art of additive manufacturing techniques for the production of bone tissue engineering (BTE) scaffolds. The most well-known of these techniques include: stereolithography, selective laser sintering, fused deposition modelling and three-dimensional printing. This review analyses in detail the basic physical principles and main applications of these techniques and presents a list of biomaterials for BTE applications, including commercial trademarks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183079
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http://dx.doi.org/10.1016/j.msec.2019.03.037DOI Listing
July 2019
18 Reads

Advanced biomedical applications of carbon nanotube.

Mater Sci Eng C Mater Biol Appl 2019 Jul 13;100:616-630. Epub 2019 Mar 13.

College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala, India. Electronic address:

With advances in nanotechnology, the applications of nanomaterial are developing widely and greatly. The characteristic properties of carbon nanotubes (CNTs) make them the most selective candidate for various multi-functional applications. The greater surface area of the CNTs in addition to the capability to manipulate the surfaces and dimensions has provided greater potential for this nanomaterial. Read More

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http://dx.doi.org/10.1016/j.msec.2019.03.043DOI Listing
July 2019
5 Reads

Supercritical CO technology: The next standard sterilization technique?

Mater Sci Eng C Mater Biol Appl 2019 Jun 31;99:520-540. Epub 2019 Jan 31.

Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Porto, Portugal. Electronic address:

Sterilization of implantable medical devices is of most importance to avoid surgery related complications such as infection and rejection. Advances in biotechnology fields, such as tissue engineering, have led to the development of more sophisticated and complex biomedical devices that are often composed of natural biomaterials. This complexity poses a challenge to current sterilization techniques which frequently damage materials upon sterilization. Read More

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http://dx.doi.org/10.1016/j.msec.2019.01.121DOI Listing
June 2019
3 Reads

Recent advances of collagen-based biomaterials: Multi-hierarchical structure, modification and biomedical applications.

Mater Sci Eng C Mater Biol Appl 2019 Jun 19;99:1509-1522. Epub 2019 Feb 19.

College of Bioresources and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China. Electronic address:

Collagen is the most abundant structural protein of connective tissues including skin, tendon, bone and cartilage in mammals. The complicated biosynthesis of nature collagen in vivo, involving numerous intracellular and extracellular steps, causes it to have a multi-hierarchical fibrous architecture. The bioactivity of collagen is mostly depended on its tertiary structure or above. Read More

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http://dx.doi.org/10.1016/j.msec.2019.02.070DOI Listing
June 2019
2 Reads

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer.

Mater Sci Eng C Mater Biol Appl 2019 May 18;98:1252-1276. Epub 2019 Jan 18.

National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar, Gujarat 382355, India. Electronic address:

In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers great opportunity to treat cancer and the phenomenon is known as Enhanced permeability and retention (EPR) effect. The trends in treating cancer by making use of EPR effect is increasing day by day and generate multitudes of possibility to design novel anticancer therapeutics. This review aimed to present various factors affecting the EPR effect along with important things to know about EPR effect such as tumor perfusion, lymphatic function, interstitial penetration, vascular permeability, nanoparticle retention etc. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183263
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http://dx.doi.org/10.1016/j.msec.2019.01.066DOI Listing
May 2019
3 Reads
3.088 Impact Factor

Therapeutic angiogenesis: From conventional approaches to recent nanotechnology-based interventions.

Mater Sci Eng C Mater Biol Appl 2019 Apr 3;97:994-1008. Epub 2019 Jan 3.

Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha 2713, Qatar.

Intentional and regulated induction of blood vessels formation which is generally referred to as therapeutic angiogenesis has a lot of potential in the management of various kinds of ischemic complications as well as in wound healing, bone regeneration and tissue engineering. Conventionally, therapeutic angiogenesis relies on the controlled application of growth factors that helps to initiate the formation of blood vessels in the target tissues and bioengineered constructs. The emergence of nanotechnology in medicine, particularly its application in molecular medicine has the potential for a tremendous progress in the therapeutic angiogenesis interventions. Read More

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http://dx.doi.org/10.1016/j.msec.2019.01.006DOI Listing
April 2019
4 Reads

Recent advances on open fluidic systems for biomedical applications: A review.

Mater Sci Eng C Mater Biol Appl 2019 Apr 28;97:851-863. Epub 2018 Dec 28.

3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal; Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, Portugal. Electronic address:

Microfluidics has become an important tool to engineer microenvironments with high precision, comprising devices and methods for controlling and manipulating fluids at the submillimeter scale. A specific branch of microfluidics comprises open fluidic systems, which is mainly characterized by displaying a higher air/liquid interface when compared with traditional closed-channel setups. The use of open channel systems has enabled the design of singular architectures in devices that are simple to fabricate and to clean. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183044
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http://dx.doi.org/10.1016/j.msec.2018.12.040DOI Listing
April 2019
25 Reads

Fabrication of patterned three-dimensional micron scaled core-sheath architectures for drug patches.

Mater Sci Eng C Mater Biol Appl 2019 Apr 28;97:776-783. Epub 2018 Dec 28.

Key Laboratory for Biomedical Engineering of Education Ministry of China, Zhejiang University, Hangzhou 310027, PR China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, PR China. Electronic address:

Recent advances in selective integration of micro and nano-scaled features towards material design have paved way to enhance desirable properties or functions of biomaterials. For drug delivery applications these include improved active component encapsulation, controlled drug release and managed interaction with the intended host environment. Electrohydrodynamic (EHD) direct-printing technique is a one-step on demand fiber deposition method which enables precise micron-scaled topographic and structural enhancement during material fabrication. Read More

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http://dx.doi.org/10.1016/j.msec.2018.12.110DOI Listing
April 2019
5 Reads

Cyclodextrin-based delivery systems for cancer treatment.

Mater Sci Eng C Mater Biol Appl 2019 Mar 23;96:872-886. Epub 2018 Nov 23.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China. Electronic address:

Cyclodextrins, one of safe excipients, are able to form host-guest complexes with fitted molecules given the unique nature imparted by their structure in result of a number of pharmaceutical applications. On the other hand, targeted or responsive materials are appealing therapeutic platforms for the development of next-generation precision medications. Meanwhile, cyclodextrin-based polymers or assemblies can condense DNA and RNA in result to be used as genetic therapeutic agents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183094
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http://dx.doi.org/10.1016/j.msec.2018.11.031DOI Listing
March 2019
37 Reads

Novel sintering-free scaffolds obtained by additive manufacturing for concurrent bone regeneration and drug delivery: Proof of concept.

Mater Sci Eng C Mater Biol Appl 2019 Jan 19;94:426-436. Epub 2018 Sep 19.

Department of Materials and Ceramics Engineering, CICECO University of Aveiro, 3810-193 Aveiro, Portugal.

Advances on the fabrication of sintering-free biphasic calcium phosphate (BCP)/natural polymer composite scaffolds using robocasting as additive manufacturing technique are presented in the present work. Inks with high amounts of BCP powders (45 vol%) containing different HA/β-TCP ratios, in presence of crosslinked polymer, were successfully fine-tuned for extrusion by robocasting. The non-existence of sintering step opened the possibility to obtain drug loaded scaffolds by adding levofloxacin to the extrudable inks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183065
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http://dx.doi.org/10.1016/j.msec.2018.09.050DOI Listing
January 2019
33 Reads

Recent advances in the development of biodegradable PHB-based toughening materials: Approaches, advantages and applications.

Mater Sci Eng C Mater Biol Appl 2018 Nov 13;92:1092-1116. Epub 2017 Nov 13.

Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore; Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, 138634, Singapore. Electronic address:

Polyhydroxybutyrate (PHB) is a natural biodegradable polymer that is produced by many types of bacteria as an intracellular energy storage material. Due to its numerous advantages such as biodegradability, biocompatibility, availability and with physical properties comparable to petroleum-based thermoplastics, PHB is a potential substitute in biomedical and packaging fields. However, several physical drawbacks, such as high production cost, thermal instability, and poor mechanical properties, due to secondary crystallization and slow nucleation rate, limit its competition with traditional plastics in industrial and biomedical applications. Read More

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http://dx.doi.org/10.1016/j.msec.2017.11.006DOI Listing
November 2018
4 Reads

Biodegradable polyester shape memory polymers: Recent advances in design, material properties and applications.

Mater Sci Eng C Mater Biol Appl 2018 Nov 21;92:1061-1074. Epub 2017 Nov 21.

Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, Innovis, #08-03, 138634, Singapore. Electronic address:

Shape memory polymers (SMPs) is a class of well-studied smart materials with a variety of applications. In recent years, biodegradable polyester SMPs have received increasing attention from the research community both as academic interest and for their potential usefulness in biomedicine and soft robotics. In this contribution, the most recent progress in the area of biodegradable polyester-based SMPs is summarized with regards to their structural designs, thermomechanical properties, shape memory performance and some emerging characteristics, followed by a discussion on the specific applications of these SMPs in biomedicine and soft robotics. Read More

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http://dx.doi.org/10.1016/j.msec.2017.11.008DOI Listing
November 2018
3 Reads

Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics.

Mater Sci Eng C Mater Biol Appl 2018 Nov 5;92:1041-1060. Epub 2018 Jan 5.

BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, 1 CREATE Way, Enterprise Wing, Singapore 138602, Singapore. Electronic address:

Recent advancements in biopharmaceutical industry have facilitated the development of novel bioactive macromolecular therapeutics. One of the challenges towards the clinical use of these biomacromolecules lies in the selection of appropriate carriers to protect, deliver and release them in vivo to maximize their pharmacological effects. Micro/nanoparticles made from biodegradable poly (d,l-lactic-co-glycolic acid) (PLGA) have been explored as delivery vehicles for therapeutics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173414
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http://dx.doi.org/10.1016/j.msec.2017.12.036DOI Listing
November 2018
12 Reads

Advances in thermosensitive polymer-grafted platforms for biomedical applications.

Mater Sci Eng C Mater Biol Appl 2018 Nov 9;92:1016-1030. Epub 2018 Feb 9.

Institute of Research and Development, Duy Tan University, Da Nang City 550000, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 1A TL29, District 12, Hochiminh City 700000, Viet Nam; Graduate School of Science and Technology Viet Nam, Vietnam Academy of Science and Technology, 1A TL29, District 12, Hochiminh City 700000, Viet Nam. Electronic address:

Studies on "smart" polymeric material performing environmental stimuli such as temperature, pH, magnetic field, enzyme and photo-sensation have recently paid much attention to practical applications. Among of them, thermo-responsive grafted copolymers, amphiphilic steroids as well as polyester molecules have been utilized in the fabrication of several multifunctional platforms. Indeed, they performed a strikingly functional improvement comparing to some original materials and exhibited a holistic approach for biomedical applications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173407
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http://dx.doi.org/10.1016/j.msec.2018.02.006DOI Listing
November 2018
5 Reads

Biodegradable stents for coronary artery disease treatment: Recent advances and future perspectives.

Mater Sci Eng C Mater Biol Appl 2018 Oct 11;91:163-178. Epub 2018 May 11.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

Cardiovascular diseases are one of the major causes of human death in the world. Endovascular stents are the most important implantation devices in cardiovascular intervention, and their efficacy determines the success of cardiovascular disease treatment. In order to reduce the long-term side effects of permanent metallic stents, such as subacute thrombosis and in-stent restenosis, a new generation of endovascular stents so-called "biodegradable stents (BDSs)" is currently being vigorously developed and considered as the most promising candidate. Read More

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http://dx.doi.org/10.1016/j.msec.2018.04.100DOI Listing
October 2018
4 Reads

Advances on graphene-based nanomaterials for biomedical applications.

Mater Sci Eng C Mater Biol Appl 2018 Sep 4;90:764-780. Epub 2018 May 4.

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

Graphene-based nanomaterials, such as graphene oxide and reduced graphene oxide, have been attracting increasing attention in the field of biology and biomedicine over the past few years. Incorporation of these novel materials with drug, gene, photosensitizer and other cargos to construct novel delivery systems has witnessed rapid advance on the basis of their large surface area, distinct surface properties, excellent biocompatibility and pH sensitivity. Moreover, the inherent photothermal effect of these appealing materials enables them with the ability of killing targeting cells via a physical mechanism. Read More

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http://dx.doi.org/10.1016/j.msec.2018.05.018DOI Listing
September 2018
3 Reads

Biomedical application and controlled drug release of electrospun fibrous materials.

Mater Sci Eng C Mater Biol Appl 2018 Sep 4;90:750-763. Epub 2018 May 4.

Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China. Electronic address:

Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properties such as high surface to volume ratio, high porous, ease of fabrication and adaptability and so on. Read More

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http://dx.doi.org/10.1016/j.msec.2018.05.007DOI Listing
September 2018
7 Reads

Biodegradable dendrimers for drug delivery.

Authors:
Da Huang Decheng Wu

Mater Sci Eng C Mater Biol Appl 2018 Sep 10;90:713-727. Epub 2018 Mar 10.

Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.. Electronic address:

Dendrimers, as a type of artificial polymers with unique structural features, have been extensively explored for their applications in biomedical fields, especially in drug delivery. However, one important concern about the most commonly used dendrimers exists - the nondegradability, which may cause side effects induced by the accumulation of synthetic polymers in cells or tissues. Therefore, biodegradable dendrimers incorporating biodegradability with merits of dendrimers such as well-defined architectures, copious internal cavities and surface functionalities, are much more promising for developing novel nontoxic drug carriers. Read More

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http://dx.doi.org/10.1016/j.msec.2018.03.002DOI Listing
September 2018
3 Reads
3.090 Impact Factor

Advancing the frontiers of silk fibroin protein-based materials for futuristic electronics and clinical wound-healing (Invited review).

Mater Sci Eng C Mater Biol Appl 2018 May 31;86:151-172. Epub 2018 Jan 31.

Institute of Materials Research and Engineering, A*STAR, 2 Fusionopolis Way, Innovis, Singapore 138634, Singapore. Electronic address:

The present review will introduce the basic concepts of silk-based electronics/optoelectronics including the latest technological advances on the use of silk fibroin in combination with other functional components, with an emphasis on improving the performance of next-generation silk-based materials. It also highlights the patterning of silk fibroin to produce micro/nano-scale features, as well as the functionalization of silk fibroin to impart antimicrobial (i.e. Read More

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http://dx.doi.org/10.1016/j.msec.2018.01.007DOI Listing
May 2018
10 Reads

Spatially and Temporally Controlled Hydrogels for Tissue Engineering.

Mater Sci Eng R Rep 2017 Sep 25;119:1-35. Epub 2017 Jul 25.

Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels' properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Read More

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http://dx.doi.org/10.1016/j.mser.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708586PMC
September 2017
38 Reads

Bone regeneration: Biomaterials as local delivery systems with improved osteoinductive properties.

Mater Sci Eng C Mater Biol Appl 2018 Jan 11;82:363-371. Epub 2017 Apr 11.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal. Electronic address:

Bone is a mineralized conjunctive tissue, with a unique trauma healing capability. However, the replacement or regeneration of lost bone is not always successful and becomes more difficult the wider the bone defect. A significant growth in the demand for orthopedic and maxillofacial surgical procedures as a result of population aging and increase in chronic diseases as diabetes is a fact and successful approaches for bone regeneration are still needed. Read More

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http://dx.doi.org/10.1016/j.msec.2017.04.038DOI Listing
January 2018
36 Reads

Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays.

Mater Sci Eng C Mater Biol Appl 2017 Dec 19;81:84-89. Epub 2017 Jul 19.

Chimie et Biologie des Membranes et Nano-Objets (CBMN), UMR CNRS 5248, Univ. Bordeaux, 18 Av Geoffroy St Hilaire, 33600 Pessac, France. Electronic address:

Continuous and long-term monitoring of cellular and micro-organ activity is required for new insights into physiology and novel technologies such as Organs-on-Chip. Moreover, recent advances in stem cell technology and especially in the field of diabetes call for non-invasive approaches in quality testing of the large quantities of surrogate pancreatic islets to be generated. Electrical activity of such a micro-organ results in single cell action potentials (APs) of high frequency and in low frequency changes in local field potentials (slow potentials or SPs), reflecting coupled cell activity and overall organ physiology. Read More

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http://dx.doi.org/10.1016/j.msec.2017.07.028DOI Listing
December 2017
59 Reads

Instrumental methods and techniques for structural and physicochemical characterization of biomaterials and bone tissue: A review.

Mater Sci Eng C Mater Biol Appl 2017 Oct 18;79:930-949. Epub 2017 May 18.

University of Niš, Faculty of Mechanical Engineering, RS-18000 Niš, Serbia.

A review of recent advances in instrumental methods and techniques for structural and physicochemical characterization of biomaterials and bone tissue is presented in this paper. In recent years, biomaterials attracted great attention primarily because of the wide range of biomedical applications. This paper focuses on the practical aspects of instrumental methods and techniques that were most often applied (X-ray methods, vibrational spectroscopy (IR and Raman), magnetic-resonance spectroscopy (NMR and ESR), mass spectrometry (MS), atomic absorption spectrometry (AAS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES), thermogravimetry (TG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC), scanning electron microscopy (SEM), transmission electron microscopy (TEM)) in the structural investigation and physicochemical characterization of biomaterials and bone tissue. Read More

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http://dx.doi.org/10.1016/j.msec.2017.05.127DOI Listing
October 2017
9 Reads

Naturally derived proteins and glycosaminoglycan scaffolds for tissue engineering applications.

Mater Sci Eng C Mater Biol Appl 2017 Sep 5;78:1277-1299. Epub 2017 Apr 5.

Warsaw University of Technology, Faculty of Material Science and Engineering, 141 Woloska str., 02-507 Warsaw, Poland. Electronic address:

Tissue engineering (TE) aims to mimic the complex environment where organogenesis takes place using advanced materials to recapitulate the tissue niche. Cells, three-dimensional scaffolds and signaling factors are the three main and essential components of TE. Over the years, materials and processes have become more and more sophisticated, allowing researchers to precisely tailor the final chemical, mechanical, structural and biological features of the designed scaffolds. Read More

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http://dx.doi.org/10.1016/j.msec.2017.04.016DOI Listing
September 2017
6 Reads

Scavenging free radicals and soaring osteoinduction by extra cellular matrix protein-based nanocomposites on degenerative bone treatments.

Mater Sci Eng C Mater Biol Appl 2017 Aug 25;77:1189-1195. Epub 2017 Mar 25.

Department of Microbiology, Periyar University, Periyar Palkalai Nagar, Salem 636 011, Tamil Nadu, India. Electronic address:

A number of materials are now available to alleviate the ever-growing bone disruption. However, these are inadequate and inappropriate for addressing issues associated natural process of aging and degeneration of bone due to diseases. This study advances the existing material and offers more privileged and synergistically active remedy for these conditions. Read More

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http://dx.doi.org/10.1016/j.msec.2017.03.223DOI Listing
August 2017
16 Reads