60 results match your criteria Advances In Materials Science And Engineering[Journal]


Advances in additive manufacturing for bone tissue engineering scaffolds.

Mater Sci Eng C Mater Biol Appl 2019 Jul 13;100:631-644. Epub 2019 Mar 13.

CONICET, National Scientific and Technical Research Council, Argentina; LAMEIN, Faculty of Exact Sciences and Engineering, National University of Tucuman, Argentina.

This article reviews the current state of the art of additive manufacturing techniques for the production of bone tissue engineering (BTE) scaffolds. The most well-known of these techniques include: stereolithography, selective laser sintering, fused deposition modelling and three-dimensional printing. This review analyses in detail the basic physical principles and main applications of these techniques and presents a list of biomaterials for BTE applications, including commercial trademarks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183079
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http://dx.doi.org/10.1016/j.msec.2019.03.037DOI Listing
July 2019
2 Reads

Advanced biomedical applications of carbon nanotube.

Mater Sci Eng C Mater Biol Appl 2019 Jul 13;100:616-630. Epub 2019 Mar 13.

College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala, India. Electronic address:

With advances in nanotechnology, the applications of nanomaterial are developing widely and greatly. The characteristic properties of carbon nanotubes (CNTs) make them the most selective candidate for various multi-functional applications. The greater surface area of the CNTs in addition to the capability to manipulate the surfaces and dimensions has provided greater potential for this nanomaterial. Read More

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http://dx.doi.org/10.1016/j.msec.2019.03.043DOI Listing
July 2019
2 Reads

Supercritical CO technology: The next standard sterilization technique?

Mater Sci Eng C Mater Biol Appl 2019 Jun 31;99:520-540. Epub 2019 Jan 31.

Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Porto, Portugal. Electronic address:

Sterilization of implantable medical devices is of most importance to avoid surgery related complications such as infection and rejection. Advances in biotechnology fields, such as tissue engineering, have led to the development of more sophisticated and complex biomedical devices that are often composed of natural biomaterials. This complexity poses a challenge to current sterilization techniques which frequently damage materials upon sterilization. Read More

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http://dx.doi.org/10.1016/j.msec.2019.01.121DOI Listing

Recent advances of collagen-based biomaterials: Multi-hierarchical structure, modification and biomedical applications.

Mater Sci Eng C Mater Biol Appl 2019 Jun 19;99:1509-1522. Epub 2019 Feb 19.

College of Bioresources and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China. Electronic address:

Collagen is the most abundant structural protein of connective tissues including skin, tendon, bone and cartilage in mammals. The complicated biosynthesis of nature collagen in vivo, involving numerous intracellular and extracellular steps, causes it to have a multi-hierarchical fibrous architecture. The bioactivity of collagen is mostly depended on its tertiary structure or above. Read More

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http://dx.doi.org/10.1016/j.msec.2019.02.070DOI Listing

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer.

Mater Sci Eng C Mater Biol Appl 2019 May 18;98:1252-1276. Epub 2019 Jan 18.

National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar, Gujarat 382355, India. Electronic address:

In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers great opportunity to treat cancer and the phenomenon is known as Enhanced permeability and retention (EPR) effect. The trends in treating cancer by making use of EPR effect is increasing day by day and generate multitudes of possibility to design novel anticancer therapeutics. This review aimed to present various factors affecting the EPR effect along with important things to know about EPR effect such as tumor perfusion, lymphatic function, interstitial penetration, vascular permeability, nanoparticle retention etc. Read More

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http://dx.doi.org/10.1016/j.msec.2019.01.066DOI Listing
May 2019
3.088 Impact Factor

Therapeutic angiogenesis: From conventional approaches to recent nanotechnology-based interventions.

Mater Sci Eng C Mater Biol Appl 2019 Apr 3;97:994-1008. Epub 2019 Jan 3.

Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha 2713, Qatar.

Intentional and regulated induction of blood vessels formation which is generally referred to as therapeutic angiogenesis has a lot of potential in the management of various kinds of ischemic complications as well as in wound healing, bone regeneration and tissue engineering. Conventionally, therapeutic angiogenesis relies on the controlled application of growth factors that helps to initiate the formation of blood vessels in the target tissues and bioengineered constructs. The emergence of nanotechnology in medicine, particularly its application in molecular medicine has the potential for a tremendous progress in the therapeutic angiogenesis interventions. Read More

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http://dx.doi.org/10.1016/j.msec.2019.01.006DOI Listing
April 2019
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Recent advances on open fluidic systems for biomedical applications: A review.

Mater Sci Eng C Mater Biol Appl 2019 Apr 28;97:851-863. Epub 2018 Dec 28.

3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal; Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, Portugal. Electronic address:

Microfluidics has become an important tool to engineer microenvironments with high precision, comprising devices and methods for controlling and manipulating fluids at the submillimeter scale. A specific branch of microfluidics comprises open fluidic systems, which is mainly characterized by displaying a higher air/liquid interface when compared with traditional closed-channel setups. The use of open channel systems has enabled the design of singular architectures in devices that are simple to fabricate and to clean. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183044
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http://dx.doi.org/10.1016/j.msec.2018.12.040DOI Listing
April 2019
12 Reads

Fabrication of patterned three-dimensional micron scaled core-sheath architectures for drug patches.

Mater Sci Eng C Mater Biol Appl 2019 Apr 28;97:776-783. Epub 2018 Dec 28.

Key Laboratory for Biomedical Engineering of Education Ministry of China, Zhejiang University, Hangzhou 310027, PR China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, PR China. Electronic address:

Recent advances in selective integration of micro and nano-scaled features towards material design have paved way to enhance desirable properties or functions of biomaterials. For drug delivery applications these include improved active component encapsulation, controlled drug release and managed interaction with the intended host environment. Electrohydrodynamic (EHD) direct-printing technique is a one-step on demand fiber deposition method which enables precise micron-scaled topographic and structural enhancement during material fabrication. Read More

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http://dx.doi.org/10.1016/j.msec.2018.12.110DOI Listing

Cyclodextrin-based delivery systems for cancer treatment.

Mater Sci Eng C Mater Biol Appl 2019 Mar 23;96:872-886. Epub 2018 Nov 23.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China. Electronic address:

Cyclodextrins, one of safe excipients, are able to form host-guest complexes with fitted molecules given the unique nature imparted by their structure in result of a number of pharmaceutical applications. On the other hand, targeted or responsive materials are appealing therapeutic platforms for the development of next-generation precision medications. Meanwhile, cyclodextrin-based polymers or assemblies can condense DNA and RNA in result to be used as genetic therapeutic agents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183094
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http://dx.doi.org/10.1016/j.msec.2018.11.031DOI Listing
March 2019
9 Reads

Novel sintering-free scaffolds obtained by additive manufacturing for concurrent bone regeneration and drug delivery: Proof of concept.

Mater Sci Eng C Mater Biol Appl 2019 Jan 19;94:426-436. Epub 2018 Sep 19.

Department of Materials and Ceramics Engineering, CICECO University of Aveiro, 3810-193 Aveiro, Portugal.

Advances on the fabrication of sintering-free biphasic calcium phosphate (BCP)/natural polymer composite scaffolds using robocasting as additive manufacturing technique are presented in the present work. Inks with high amounts of BCP powders (45 vol%) containing different HA/β-TCP ratios, in presence of crosslinked polymer, were successfully fine-tuned for extrusion by robocasting. The non-existence of sintering step opened the possibility to obtain drug loaded scaffolds by adding levofloxacin to the extrudable inks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183065
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http://dx.doi.org/10.1016/j.msec.2018.09.050DOI Listing
January 2019
16 Reads

Recent advances in the development of biodegradable PHB-based toughening materials: Approaches, advantages and applications.

Mater Sci Eng C Mater Biol Appl 2018 Nov 13;92:1092-1116. Epub 2017 Nov 13.

Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore; Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, 138634, Singapore. Electronic address:

Polyhydroxybutyrate (PHB) is a natural biodegradable polymer that is produced by many types of bacteria as an intracellular energy storage material. Due to its numerous advantages such as biodegradability, biocompatibility, availability and with physical properties comparable to petroleum-based thermoplastics, PHB is a potential substitute in biomedical and packaging fields. However, several physical drawbacks, such as high production cost, thermal instability, and poor mechanical properties, due to secondary crystallization and slow nucleation rate, limit its competition with traditional plastics in industrial and biomedical applications. Read More

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http://dx.doi.org/10.1016/j.msec.2017.11.006DOI Listing
November 2018
2 Reads

Biodegradable polyester shape memory polymers: Recent advances in design, material properties and applications.

Mater Sci Eng C Mater Biol Appl 2018 Nov 21;92:1061-1074. Epub 2017 Nov 21.

Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, Innovis, #08-03, 138634, Singapore. Electronic address:

Shape memory polymers (SMPs) is a class of well-studied smart materials with a variety of applications. In recent years, biodegradable polyester SMPs have received increasing attention from the research community both as academic interest and for their potential usefulness in biomedicine and soft robotics. In this contribution, the most recent progress in the area of biodegradable polyester-based SMPs is summarized with regards to their structural designs, thermomechanical properties, shape memory performance and some emerging characteristics, followed by a discussion on the specific applications of these SMPs in biomedicine and soft robotics. Read More

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http://dx.doi.org/10.1016/j.msec.2017.11.008DOI Listing
November 2018
1 Read

Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics.

Mater Sci Eng C Mater Biol Appl 2018 Nov 5;92:1041-1060. Epub 2018 Jan 5.

BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, 1 CREATE Way, Enterprise Wing, Singapore 138602, Singapore. Electronic address:

Recent advancements in biopharmaceutical industry have facilitated the development of novel bioactive macromolecular therapeutics. One of the challenges towards the clinical use of these biomacromolecules lies in the selection of appropriate carriers to protect, deliver and release them in vivo to maximize their pharmacological effects. Micro/nanoparticles made from biodegradable poly (d,l-lactic-co-glycolic acid) (PLGA) have been explored as delivery vehicles for therapeutics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173414
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http://dx.doi.org/10.1016/j.msec.2017.12.036DOI Listing
November 2018
9 Reads

Advances in thermosensitive polymer-grafted platforms for biomedical applications.

Mater Sci Eng C Mater Biol Appl 2018 Nov 9;92:1016-1030. Epub 2018 Feb 9.

Institute of Research and Development, Duy Tan University, Da Nang City 550000, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 1A TL29, District 12, Hochiminh City 700000, Viet Nam; Graduate School of Science and Technology Viet Nam, Vietnam Academy of Science and Technology, 1A TL29, District 12, Hochiminh City 700000, Viet Nam. Electronic address:

Studies on "smart" polymeric material performing environmental stimuli such as temperature, pH, magnetic field, enzyme and photo-sensation have recently paid much attention to practical applications. Among of them, thermo-responsive grafted copolymers, amphiphilic steroids as well as polyester molecules have been utilized in the fabrication of several multifunctional platforms. Indeed, they performed a strikingly functional improvement comparing to some original materials and exhibited a holistic approach for biomedical applications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173407
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http://dx.doi.org/10.1016/j.msec.2018.02.006DOI Listing
November 2018
2 Reads

Biodegradable stents for coronary artery disease treatment: Recent advances and future perspectives.

Mater Sci Eng C Mater Biol Appl 2018 Oct 11;91:163-178. Epub 2018 May 11.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

Cardiovascular diseases are one of the major causes of human death in the world. Endovascular stents are the most important implantation devices in cardiovascular intervention, and their efficacy determines the success of cardiovascular disease treatment. In order to reduce the long-term side effects of permanent metallic stents, such as subacute thrombosis and in-stent restenosis, a new generation of endovascular stents so-called "biodegradable stents (BDSs)" is currently being vigorously developed and considered as the most promising candidate. Read More

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http://dx.doi.org/10.1016/j.msec.2018.04.100DOI Listing
October 2018
1 Read

Advances on graphene-based nanomaterials for biomedical applications.

Mater Sci Eng C Mater Biol Appl 2018 Sep 4;90:764-780. Epub 2018 May 4.

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

Graphene-based nanomaterials, such as graphene oxide and reduced graphene oxide, have been attracting increasing attention in the field of biology and biomedicine over the past few years. Incorporation of these novel materials with drug, gene, photosensitizer and other cargos to construct novel delivery systems has witnessed rapid advance on the basis of their large surface area, distinct surface properties, excellent biocompatibility and pH sensitivity. Moreover, the inherent photothermal effect of these appealing materials enables them with the ability of killing targeting cells via a physical mechanism. Read More

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http://dx.doi.org/10.1016/j.msec.2018.05.018DOI Listing
September 2018
1 Read

Biomedical application and controlled drug release of electrospun fibrous materials.

Mater Sci Eng C Mater Biol Appl 2018 Sep 4;90:750-763. Epub 2018 May 4.

Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China. Electronic address:

Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properties such as high surface to volume ratio, high porous, ease of fabrication and adaptability and so on. Read More

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http://dx.doi.org/10.1016/j.msec.2018.05.007DOI Listing
September 2018
4 Reads

Biodegradable dendrimers for drug delivery.

Authors:
Da Huang Decheng Wu

Mater Sci Eng C Mater Biol Appl 2018 Sep 10;90:713-727. Epub 2018 Mar 10.

Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.. Electronic address:

Dendrimers, as a type of artificial polymers with unique structural features, have been extensively explored for their applications in biomedical fields, especially in drug delivery. However, one important concern about the most commonly used dendrimers exists - the nondegradability, which may cause side effects induced by the accumulation of synthetic polymers in cells or tissues. Therefore, biodegradable dendrimers incorporating biodegradability with merits of dendrimers such as well-defined architectures, copious internal cavities and surface functionalities, are much more promising for developing novel nontoxic drug carriers. Read More

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http://dx.doi.org/10.1016/j.msec.2018.03.002DOI Listing
September 2018
3.090 Impact Factor

Advancing the frontiers of silk fibroin protein-based materials for futuristic electronics and clinical wound-healing (Invited review).

Mater Sci Eng C Mater Biol Appl 2018 May 31;86:151-172. Epub 2018 Jan 31.

Institute of Materials Research and Engineering, A*STAR, 2 Fusionopolis Way, Innovis, Singapore 138634, Singapore. Electronic address:

The present review will introduce the basic concepts of silk-based electronics/optoelectronics including the latest technological advances on the use of silk fibroin in combination with other functional components, with an emphasis on improving the performance of next-generation silk-based materials. It also highlights the patterning of silk fibroin to produce micro/nano-scale features, as well as the functionalization of silk fibroin to impart antimicrobial (i.e. Read More

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http://dx.doi.org/10.1016/j.msec.2018.01.007DOI Listing
May 2018
5 Reads

Spatially and Temporally Controlled Hydrogels for Tissue Engineering.

Mater Sci Eng R Rep 2017 Sep 25;119:1-35. Epub 2017 Jul 25.

Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels' properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Read More

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http://dx.doi.org/10.1016/j.mser.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708586PMC
September 2017
24 Reads

Bone regeneration: Biomaterials as local delivery systems with improved osteoinductive properties.

Mater Sci Eng C Mater Biol Appl 2018 Jan 11;82:363-371. Epub 2017 Apr 11.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal. Electronic address:

Bone is a mineralized conjunctive tissue, with a unique trauma healing capability. However, the replacement or regeneration of lost bone is not always successful and becomes more difficult the wider the bone defect. A significant growth in the demand for orthopedic and maxillofacial surgical procedures as a result of population aging and increase in chronic diseases as diabetes is a fact and successful approaches for bone regeneration are still needed. Read More

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http://dx.doi.org/10.1016/j.msec.2017.04.038DOI Listing
January 2018
20 Reads

Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays.

Mater Sci Eng C Mater Biol Appl 2017 Dec 19;81:84-89. Epub 2017 Jul 19.

Chimie et Biologie des Membranes et Nano-Objets (CBMN), UMR CNRS 5248, Univ. Bordeaux, 18 Av Geoffroy St Hilaire, 33600 Pessac, France. Electronic address:

Continuous and long-term monitoring of cellular and micro-organ activity is required for new insights into physiology and novel technologies such as Organs-on-Chip. Moreover, recent advances in stem cell technology and especially in the field of diabetes call for non-invasive approaches in quality testing of the large quantities of surrogate pancreatic islets to be generated. Electrical activity of such a micro-organ results in single cell action potentials (APs) of high frequency and in low frequency changes in local field potentials (slow potentials or SPs), reflecting coupled cell activity and overall organ physiology. Read More

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http://dx.doi.org/10.1016/j.msec.2017.07.028DOI Listing
December 2017
35 Reads

Instrumental methods and techniques for structural and physicochemical characterization of biomaterials and bone tissue: A review.

Mater Sci Eng C Mater Biol Appl 2017 Oct 18;79:930-949. Epub 2017 May 18.

University of Niš, Faculty of Mechanical Engineering, RS-18000 Niš, Serbia.

A review of recent advances in instrumental methods and techniques for structural and physicochemical characterization of biomaterials and bone tissue is presented in this paper. In recent years, biomaterials attracted great attention primarily because of the wide range of biomedical applications. This paper focuses on the practical aspects of instrumental methods and techniques that were most often applied (X-ray methods, vibrational spectroscopy (IR and Raman), magnetic-resonance spectroscopy (NMR and ESR), mass spectrometry (MS), atomic absorption spectrometry (AAS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES), thermogravimetry (TG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC), scanning electron microscopy (SEM), transmission electron microscopy (TEM)) in the structural investigation and physicochemical characterization of biomaterials and bone tissue. Read More

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http://dx.doi.org/10.1016/j.msec.2017.05.127DOI Listing
October 2017
4 Reads

Naturally derived proteins and glycosaminoglycan scaffolds for tissue engineering applications.

Mater Sci Eng C Mater Biol Appl 2017 Sep 5;78:1277-1299. Epub 2017 Apr 5.

Warsaw University of Technology, Faculty of Material Science and Engineering, 141 Woloska str., 02-507 Warsaw, Poland. Electronic address:

Tissue engineering (TE) aims to mimic the complex environment where organogenesis takes place using advanced materials to recapitulate the tissue niche. Cells, three-dimensional scaffolds and signaling factors are the three main and essential components of TE. Over the years, materials and processes have become more and more sophisticated, allowing researchers to precisely tailor the final chemical, mechanical, structural and biological features of the designed scaffolds. Read More

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http://dx.doi.org/10.1016/j.msec.2017.04.016DOI Listing
September 2017
3 Reads

Scavenging free radicals and soaring osteoinduction by extra cellular matrix protein-based nanocomposites on degenerative bone treatments.

Mater Sci Eng C Mater Biol Appl 2017 Aug 25;77:1189-1195. Epub 2017 Mar 25.

Department of Microbiology, Periyar University, Periyar Palkalai Nagar, Salem 636 011, Tamil Nadu, India. Electronic address:

A number of materials are now available to alleviate the ever-growing bone disruption. However, these are inadequate and inappropriate for addressing issues associated natural process of aging and degeneration of bone due to diseases. This study advances the existing material and offers more privileged and synergistically active remedy for these conditions. Read More

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http://dx.doi.org/10.1016/j.msec.2017.03.223DOI Listing
August 2017
10 Reads

Liquid formulation containing doxorubicin-loaded lipid-core nanocapsules: Cytotoxicity in human breast cancer cell line and in vitro uptake mechanism.

Mater Sci Eng C Mater Biol Appl 2017 Jul 14;76:374-382. Epub 2017 Mar 14.

Programa de Pós-Graduação em Nanotecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre 90610-000, RS, Brazil; Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, Porto Alegre 91501-970, RS, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre 90610-000, RS, Brazil. Electronic address:

Cancer is a major public health problem in the world, being breast cancer the most frequent cancer affecting women. Despite advances in detection and treatment, mortality rates remain high. Therefore, new approaches for breast cancer treatments are necessary. Read More

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http://dx.doi.org/10.1016/j.msec.2017.03.099DOI Listing
July 2017
20 Reads

Modeling the permeability of multiaxial electrospun poly(ε-caprolactone)-gelatin hybrid fibers for controlled doxycycline release.

Mater Sci Eng C Mater Biol Appl 2017 Jul 14;76:161-170. Epub 2017 Mar 14.

School of Chemical Engineering, Oklahoma State University, Stillwater, 74078, OK, United States. Electronic address:

Recent advances in electrospinning allow the formation of multiple layers of micro and nanosize fibers to regulate drug/therapeutic agent release. Although there has been significant progress in fiber formation techniques and drug loading, fundamental models providing insights into controlling individual permeabilities is lacking. In this regard, we first explored forming coaxial hybrid fibers from hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic gelatin (GT) in three different configurations, and the release of hydrophilic doxycycline (Dox) at 37°C over five days. Read More

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http://dx.doi.org/10.1016/j.msec.2017.03.093DOI Listing
July 2017
10 Reads

Electrospun nanofibers for wound healing.

Mater Sci Eng C Mater Biol Appl 2017 Jul 14;76:1413-1423. Epub 2017 Mar 14.

College of Chemical Engineering & Materials Science, Quanzhou Normal University, Quanzhou, China; Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, China. Electronic address:

Electrospinning has been widely used as a nanofiber fabrication technique. Its simple process, cost effectiveness and versatility have appealed to materials scientists globally. Pristine polymeric nanofibers or composite nanofibers with dissimilar morphologies and multidimensional assemblies ranging from one dimension (1D) to three dimensions (3D) can be obtained from electrospinning. Read More

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http://dx.doi.org/10.1016/j.msec.2017.03.034DOI Listing
July 2017
38 Reads

Nanomaterials made of non-toxic metallic sulfides: A systematic review of their potential biomedical applications.

Mater Sci Eng C Mater Biol Appl 2017 Jul 27;76:1305-1315. Epub 2017 Feb 27.

Laboratorio de Investigación Interdisciplinaria, Área de Nanoestructuras y Biomateriales, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, 37684 Guanajuato, México.. Electronic address:

Metallic sulfides involve the chemical bonding of one or more sulfur atoms to a metal. Metallic sulfides are cheap, abundant semiconductor materials that can be used for several applications. However, an important and emerging use for non-toxic metallic sulfides in biomedical applications has arisen quickly in the medical field. Read More

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http://dx.doi.org/10.1016/j.msec.2017.02.120DOI Listing
July 2017
31 Reads

Advances in ultra high molecular weight polyethylene/hydroxyapatite composites for biomedical applications: A brief review.

Mater Sci Eng C Mater Biol Appl 2017 Jul 16;76:1248-1262. Epub 2017 Feb 16.

Department of Chemical Engineering, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.

Ultra high molecular weight polyethylene (UHMWPE) is a semicrystalline polymer that has been applied, as a bearing surface in total human joint replacements and artificial bones. UHMWPE has a superior wear resistance, low-friction surface, biological inertness, high levels of strength, creep resistance and low friction coefficient. However, the wear debris generated during the joint motions could cause problem in human implant, such as osteolysis and loosening. Read More

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http://dx.doi.org/10.1016/j.msec.2017.02.070DOI Listing
July 2017
2 Reads
3.088 Impact Factor

Personalized plasma-based medicine to treat age-related diseases.

Mater Sci Eng C Mater Biol Appl 2017 May 13;74:459-464. Epub 2016 Dec 13.

Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain; NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country, School of Pharmacy, Vitoria, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain. Electronic address:

As social and health needs are changing, new challenges to develop innovative alternatives arise to address unmet medical needs. Personalized medicine is emerging as a promising and appealing therapeutic option. The use of patient's own plasma and platelets as therapeutics is providing new avenues in the treatment of acute and chronic tissue injuries by promoting tissue repair and regeneration. Read More

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http://dx.doi.org/10.1016/j.msec.2016.12.040DOI Listing
May 2017
6 Reads

Ion-substituted calcium phosphate coatings deposited by plasma-assisted techniques: A review.

Mater Sci Eng C Mater Biol Appl 2017 May 8;74:219-229. Epub 2016 Dec 8.

Rizzoli Orthopaedic Institute, NanoBiotechnology Laboratory (NaBi), Research Innovation and Technology Department (RIT), via di Barbiano 1/10, Bologna 40136, Italy.

One of the main critical aspects behind the failure or success of an implant resides in its ability to fast bond with the surrounding bone. To boost osseointegration, the ideal implant material should exhibit composition and structure similar to those of biological apatite. To this aim, the most common approach is to coat the implant surface with a coating of hydroxyapatite (HA), resembling the main component of mineralized tissues. Read More

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http://dx.doi.org/10.1016/j.msec.2016.12.018DOI Listing

A comprehensive study on the fabrication and properties of biocomposites of poly(lactic acid)/ceramics for bone tissue engineering.

Mater Sci Eng C Mater Biol Appl 2017 Jan 7;70(Pt 1):897-912. Epub 2016 Sep 7.

Department of Chemical and Petroleum Engineering, Sharif University of Technology, P.O. Box 11155-9465, Tehran, Iran.

The fabrication of a suitable scaffold material is one of the major challenges for bone tissue engineering. Poly(lactic acid) (PLA) is one of the most favorable matrix materials in bone tissue engineering owing to its biocompatibility and biodegradability. However, PLA suffers from some shortcomings including low degradation rate, low cell adhesion caused by its hydrophobic property, and inflammatory reactions in vivo due to its degradation product, lactic acid. Read More

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http://dx.doi.org/10.1016/j.msec.2016.09.008DOI Listing
January 2017

Enhanced near-infrared photoacoustic imaging of silica-coated rare-earth doped nanoparticles.

Mater Sci Eng C Mater Biol Appl 2017 Jan 7;70(Pt 1):340-346. Epub 2016 Sep 7.

Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore. Electronic address:

Near-infrared photoacoustic (PA) imaging is an emerging diagnostic technology that utilizes the tissue transparent window to achieve improved contrast and spatial resolution for deep tissue imaging. In this study, we investigated the enhancement effect of the SiO shell on the PA property of our core/shell rare-earth nanoparticles (REs) consisting of an active rare-earth doped core of NaYF:Yb,Er (REDNPs) and an undoped NaYF shell. We observed that the PA signal amplitude increased with SiO shell thickness. Read More

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http://dx.doi.org/10.1016/j.msec.2016.09.018DOI Listing
January 2017
22 Reads

Orbital implants: State-of-the-art review with emphasis on biomaterials and recent advances.

Mater Sci Eng C Mater Biol Appl 2016 Dec 8;69:1410-28. Epub 2016 Aug 8.

Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.

In the treatment of severe oculo-orbital traumas, intraocular malignancies or other life-threatening conditions it is sometimes necessary to surgically remove the patient's diseased eye. Following the removal of the eye, an orbital implant is inserted into the anophthalmic socket in order to provide satisfactory volume replacement and restore the aesthetic appearance of a normal eye. Over the last decades, the implant design and the criteria of materials selection evolved from simple non-porous polymeric sphere to devices with more complex shape and functionalities for ensuring better clinical outcomes in the long-term. Read More

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http://dx.doi.org/10.1016/j.msec.2016.08.003DOI Listing
December 2016
1 Read

Fabrication of dense α-alumina layer on Ti-6Al-4V alloy hybrid for bearing surfaces of artificial hip joint.

Mater Sci Eng C Mater Biol Appl 2016 Dec 12;69:1229-39. Epub 2016 Aug 12.

Department of Biomedical Sciences, College of Life & Health Sciences, Chubu University,1200 Matsumoto cho, Kasugai, Aichi 487-8501, Japan.

Recent advances in hip replacements are focused towards producing reliable bearing surfaces to enhance their longevity. In this perspective, progressive attempts have been made to improve the wear resistance of polyethylene to eliminate osteolysis and mechanical reliability of brittle alumina ceramics, but in vain. It is proposed that both high wear resistance and mechanical reliability can be retained if a thin layer of dense alumina is formed onto high toughness Ti-6Al-4V alloy. Read More

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http://dx.doi.org/10.1016/j.msec.2016.08.025DOI Listing
December 2016
9 Reads

Two dimension (2-D) graphene-based nanomaterials as signal amplification elements in electrochemical microfluidic immune-devices: Recent advances.

Mater Sci Eng C Mater Biol Appl 2016 Nov 8;68:482-493. Epub 2016 Jun 8.

Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Graphene is a 2-D carbon nanomaterial with many distinctive properties that are electrochemically beneficial, such as large surface-to-volume ratio, lowered power usage, high conductivity and electron mobility. Graphene-based electrochemical immune-devices have recently gained much importance for detecting antigens and biomarkers responsible for cancer diagnosis. This review describes fabrication and chemical modification of the surfaces of graphene for immunesensing applications. Read More

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http://dx.doi.org/10.1016/j.msec.2016.06.023DOI Listing
November 2016
13 Reads

Advances in peripheral nervous system regenerative therapeutic strategies: A biomaterials approach.

Mater Sci Eng C Mater Biol Appl 2016 Aug 16;65:425-32. Epub 2016 Apr 16.

Centre for Nanotechnology & Regenerative Medicine, Division of Surgery and Interventional Science, University College of London, London, UK; Royal Free London NHS Foundation Trust Hospital, London, UK. Electronic address:

Peripheral nerve injury is a very common medical condition with varying clinical severity but always great impact on the patients' productivity and the quality of life. Even the current 1st-choice surgical therapeutic approach or the "gold standard" as frequently called in clinical practice, is not addressing the problem efficiently and cost-effectively, increasing the mortality through the need of a second surgical intervention, while it does not take into account the several different types of nerves involved in peripheral nerve injuries. Neural tissue engineering approaches could potentially offer a very promising and attractive tool for the efficient peripheral nerve injury management, not only by mechanically building the gap, but also by inducing neuroregenerative mechanisms in a well-regulated microenvironment which would mimic the natural environment of the specific nerve type involved in the injury to obtain an optimum clinical outcome. Read More

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http://dx.doi.org/10.1016/j.msec.2016.04.048DOI Listing
August 2016
6 Reads

Stimulus-responsive hydrogels: Theory, modern advances, and applications.

Mater Sci Eng R Rep 2015 Jul 16;93:1-49. Epub 2015 May 16.

McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, United States; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, United States; College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States.

Over the past century, hydrogels have emerged as effective materials for an immense variety of applications. The unique network structure of hydrogels enables very high levels of hydrophilicity and biocompatibility, while at the same time exhibiting the soft physical properties associated with living tissue, making them ideal biomaterials. Stimulus-responsive hydrogels have been especially impactful, allowing for unprecedented levels of control over material properties in response to external cues. Read More

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http://dx.doi.org/10.1016/j.mser.2015.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847551PMC
July 2015
4 Reads

High-permeability functionalized silicone magnetic microspheres with low autofluorescence for biomedical applications.

Mater Sci Eng C Mater Biol Appl 2016 May 13;62:860-9. Epub 2016 Feb 13.

Elon University, 100 Campus Drive, Elon, NC 27244, USA. Electronic address:

Functionalized magnetic microspheres are widely used for cell separations, isolation of proteins and other biomolecules, in vitro diagnostics, tissue engineering, and microscale force spectroscopy. We present here the synthesis and characterization of a silicone magnetic microsphere which can be produced in diameters ranging from 0.5 to 50 μm via emulsion polymerization of a silicone ferrofluid precursor. Read More

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http://dx.doi.org/10.1016/j.msec.2016.01.094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588664PMC
May 2016
6 Reads

Development of meniscus substitutes using a mixture of biocompatible polymers and extra cellular matrix components by electrospinning.

Mater Sci Eng C Mater Biol Appl 2016 Apr 9;61:893-905. Epub 2016 Jan 9.

Centro de Física Aplicada y Tecnología Avanzada (CFATA), Universidad Nacional Autónoma de México, Campus Juriquilla, Blvd. Juriquilla 3000, C.P. 76230, Querétaro, Mexico. Electronic address:

Despite the significant advances in the meniscus tissue engineering field, it is difficult to recreate the complex structure and organization of the collagenous matrix of the meniscus. In this work, we developed a meniscus prototype to be used as substitute or scaffold for the regeneration of the meniscal matrix, recreating the differential morphology of the meniscus by electrospinning. Synthetic biocompatible polymers were combined with the extracellular matrix component, collagen and used to replicate the meniscus. Read More

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http://dx.doi.org/10.1016/j.msec.2016.01.018DOI Listing

Bioengineered silk scaffolds in 3D tissue modeling with focus on mammary tissues.

Mater Sci Eng C Mater Biol Appl 2016 Feb 9;59:1168-1180. Epub 2015 Oct 9.

Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA. Electronic address:

In vitro generation of three-dimensional (3D) biological tissues and organ-like structures is a promising strategy to study and closely model complex aspects of the molecular, cellular, and physiological interactions of tissue. In particular, in vitro 3D tissue modeling holds promises to further our understanding of breast development. Indeed, biologically relevant 3D structures that combine mammary cells and engineered matrices have improved our knowledge of mammary tissue growth, organization, and differentiation. Read More

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http://dx.doi.org/10.1016/j.msec.2015.10.007DOI Listing
February 2016
1 Read

Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents.

Mater Sci Eng C Mater Biol Appl 2016 Feb 3;59:324-332. Epub 2015 Oct 3.

Hamlyn Centre for Robotic Surgery, Institute of Global Health Innovation and Department of Surgery and Cancer, Imperial College London, UK.

GNRs are emerging as a new class of probes for theradiagnostic applications thanks to their unique optical properties. However, the achievement of proper nanoconstructs requires the synthesis of highly pure GNRs with well-defined aspect ratio (AR), in addition to extensive surface chemistry modification to provide them with active targeting and, possibly, multifunctionality. In this work, we refined the method of the seed mediated growth and developed a robust procedure for the fabrication of GNRs with specific AR. Read More

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http://dx.doi.org/10.1016/j.msec.2015.09.101DOI Listing
February 2016
7 Reads

Inorganic hemostats: The state-of-the-art and recent advances.

Mater Sci Eng C Mater Biol Appl 2016 Jan 5;58:1255-68. Epub 2015 Sep 5.

Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia; Department of Mechanical & Industrial Engineering, Ryerson University, Toronto M5B 2K3, ON, Canada. Electronic address:

Hemorrhage is the most common cause of death both in hospitals and on the battlefield. The need for an effective hemostatic agent remains, since all injuries are not amenable to tourniquet use. There are many topical hemostatic agents and dressings available to control severe bleeding. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931153033
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http://dx.doi.org/10.1016/j.msec.2015.09.008DOI Listing
January 2016
3 Reads

Effect of nanocomposite packaging containing ZnO on growth of Bacillus subtilis and Enterobacter aerogenes.

Mater Sci Eng C Mater Biol Appl 2016 Jan 25;58:1058-63. Epub 2015 Sep 25.

National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Recent advances in nanotechnology have opened new windows in active food packaging. Nano-sized ZnO is an inexpensive material with potential antimicrobial properties. The aim of the present study is to evaluate the antibacterial effect of low density Polyethylene (LDPE) containing ZnO nanoparticles on Bacillus subtilis and Enterobacter aerogenes. Read More

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http://dx.doi.org/10.1016/j.msec.2015.09.078DOI Listing
January 2016
22 Reads

Nanoparticles incorporating pH-responsive surfactants as a viable approach to improve the intracellular drug delivery.

Mater Sci Eng C Mater Biol Appl 2015 Dec 26;57:100-6. Epub 2015 Jul 26.

Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Av. Roraima 1000, 97105-900 Santa Maria, RS, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima 1000, 97105-900 Santa Maria, RS, Brazil.

The pH-responsive delivery systems have brought new advances in the field of functional nanodevices and might allow more accurate and controllable delivery of specific cargoes, which is expected to result in promising applications in different clinical therapies. Here we describe a family of chitosan-TPP (tripolyphosphate) nanoparticles (NPs) for intracellular drug delivery, which were designed using two pH-sensitive amino acid-based surfactants from the family N(α),N(ε)-dioctanoyl lysine as bioactive compounds. Low and medium molecular weight chitosan (LMW-CS and MMW-CS, respectively) were used for NP preparation, and it was observed that the size distribution for NPs with LMW-CS were smaller (~168 nm) than that for NPs prepared with MMW-CS (~310 nm). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931153022
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http://dx.doi.org/10.1016/j.msec.2015.07.036DOI Listing
December 2015
4 Reads

Synthesis, characterization, and biodistribution studies of (99m)Tc-labeled SBA-16 mesoporous silica nanoparticles.

Mater Sci Eng C Mater Biol Appl 2015 Nov 16;56:181-8. Epub 2015 Jun 16.

Centro de Desenvolvimento da Tecnologia Nuclear, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Along with anti-cancer drug delivery researches, many efforts have been done to develop new tracers for diagnostic applications. Based on advances in molecular imaging, nanoparticles can be used to visualize, characterize and measure biological process at molecular and cellular level. Therefore, the purpose of this study was to synthesize, characterize and radiolabeled mesoporous silica nanoparticles (MSNs) for in vivo applications. Read More

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http://dx.doi.org/10.1016/j.msec.2015.06.030DOI Listing
November 2015
40 Reads

Hybrid scaffold bearing polymer-siloxane Schiff base linkage for bone tissue engineering.

Mater Sci Eng C Mater Biol Appl 2015 25;52:333-42. Epub 2015 Mar 25.

Division of Tissue Engineering and Regeneration Technologies, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695012, Kerala, India. Electronic address:

Scaffolds that can provide the requisite biological cues for the fast regeneration of bone are highly relevant to the advances in tissue engineering and regenerative medicine. In the present article, we report the fabrication of a chitosan-gelatin-siloxane scaffold bearing interpolymer-siloxane Schiff base linkage, through a single-step dialdehyde cross-linking and freeze-drying method using 3-aminopropyltriethoxysilane as the siloxane precursor. Swelling of the scaffolds in phosphate buffered saline indicates enhancement with increase in siloxane concentration, whereas compressive moduli of the wet scaffolds reveal inverse dependence, owing to the presence of siloxane, rich in silanol groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931150022
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http://dx.doi.org/10.1016/j.msec.2015.03.040DOI Listing
February 2016
40 Reads

Engineering of a polymer layered bio-hybrid heart valve scaffold.

Mater Sci Eng C Mater Biol Appl 2015 Jun 11;51:263-73. Epub 2015 Mar 11.

Stem Cell and Molecular Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, TN, India. Electronic address:

Current treatment strategy for end stage valve disease involves either valvular repair or replacement with homograft/mechanical/bioprosthetic valves. In cases of recurrent stenosis/ regurgitation, valve replacement is preferred choice of treatment over valvular repair. Currently available mechanical valves primarily provide durability whereas bioprosthetic valves have superior tissue compatibility but both lack remodelling and regenerative properties making their utility limited in paediatric patients. Read More

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http://dx.doi.org/10.1016/j.msec.2015.03.009DOI Listing
June 2015
1 Read

An update on glass fiber dental restorative composites: a systematic review.

Mater Sci Eng C Mater Biol Appl 2015 Feb 8;47:26-39. Epub 2014 Nov 8.

Department of Materials Science and Engineering, University of Sheffield, Sheffield, United Kingdom.

Dentistry is a much developed field in the last few decades. New techniques have changed the conventional treatment methods as applications of new dental materials give better outcomes. The current century has suddenly forced on dentistry, a new paradigm regarding expected standards for state-of-the-art patient care. Read More

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http://dx.doi.org/10.1016/j.msec.2014.11.015DOI Listing
February 2015
8 Reads
3.088 Impact Factor