250,792 results match your criteria Advances In Manufacturing[Journal]


Role of inflammasomes in innate host defense against Entamoeba histolytica.

J Leukoc Biol 2020 Jun 4. Epub 2020 Jun 4.

Department of Microbiology, Immunology and Infectious Diseases, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada.

Intestinal amebiasis is the disease caused by the extracellular protozoan parasite Entamoeba histolytica (Eh) that induces a dynamic and heterogeneous interaction profile with the host immune system during disease pathogenesis. In 90% of asymptomatic infection, Eh resides with indigenous microbiota in the outer mucus layer of the colon without prompting an immune response. However, for reasons that remain unclear, in a minority of the Eh-infected individuals, this fine tolerated relationship is switched to a pathogenic phenotype and advanced to an increasingly complex host-parasite interaction. Read More

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http://dx.doi.org/10.1002/JLB.3MR0420-465RDOI Listing

Machine Learning in Aging: An Example of Developing Prediction Models for Serious Fall Injury in Older Adults.

J Gerontol A Biol Sci Med Sci 2020 Jun 4. Epub 2020 Jun 4.

Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC.

Background: Advances in computational algorithms and the availability of large datasets with clinically relevant characteristics provide an opportunity to develop machine learning prediction models to aid in diagnosis, prognosis, and treatment of older adults. Some studies have employed machine learning methods for prediction modeling, but skepticism of these methods remains due to lack of reproducibility and difficulty understanding the complex algorithms that underlie models. We aim to provide an overview of two common machine learning methods: decision tree and random forest. Read More

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http://dx.doi.org/10.1093/gerona/glaa138DOI Listing

Can Insoles Be Used to Improve Static and Dynamic Balance of Community-Dwelling Older Adults? A Systematic Review on Recent Advances and Future Perspectives.

J Aging Phys Act 2020 Jun 4:1-16. Epub 2020 Jun 4.

This systematic review investigated the effects of orthopedic, vibrating, and textured insoles on the postural balance of community-dwelling older adults. Articles published in English from 1999 to 2019 investigating the effects of (a) orthopedic, (b) vibrating, and (c) textured insoles on static and dynamic balance in community-dwelling older adults were considered. Twenty-four trials with a total of 634 older adults were identified. Read More

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http://dx.doi.org/10.1123/japa.2019-0293DOI Listing

Disentangling of the ecotoxicological signal using "omics" analyses, a lesson from the survey of the impact of cyanobacterial proliferations on fishes.

Authors:
Benjamin Marie

Sci Total Environ 2020 May 26;736:139701. Epub 2020 May 26.

Muséum National d'Histoire Naturelle, UMR 7245, CNRS, MNHN Molécules de Communication et Adaptation des Micro-organismes (MCAM), équipe "Cyanobactéries, Cyanotoxines et Environnement", 12 rue Buffon, CP 39, 75231 Paris Cedex 05, France. Electronic address:

Omics technologies offer unprecedented perspectives for the rational investigation of complex biological systems. Indeed, omics present the ability of offering an extensive perception of the biochemistry and physiology of the cell and of any perturbing consequences of contaminants through the joint investigation of thousands of molecular responses simultaneously; then it has recently conducted to a fervent attention by research ecotoxicologists. Beyond the presentation of latest advances, exemplified here by omics investigation of cyanobacterial deleterious effects on various fishes (at various experimental and biological scales and with various analytical tools and pipeline), the present review paper re-explores the promising perspectives and also the pitfalls of such holistic investigations of the ecotoxicological response of organisms for environmental assessment. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139701DOI Listing

The critical impacts of small RNA biogenesis proteins on aging, longevity and age-related diseases.

Ageing Res Rev 2020 Jun 1:101087. Epub 2020 Jun 1.

Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya St., 167982, Syktyvkar, Russian Federation; Pitirim Sorokin Syktyvkar State University, 55 Oktyabrsky Prosp., 167001, Syktyvkar, Russian Federation; Laboratory of Post-Genomic Research, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St., 119991, Moscow, Russian Federation; Moscow Institute of Physics and Technology, 9 Institutskiy Per., 141701, Dolgoprudny, Moscow Region, Russian Federation. Electronic address:

Small RNAs and enzymes that provide their biogenesis and functioning are involved in the organism development and coordination of biological processes, including metabolism, maintaining genome integrity, immune and stress responses. In this review, we focused on the role of small RNA biogenesis proteins in determining the aging and longevity of animals and human. A number of studies have revealed that changes in expression profiles of key enzymes, in particular proteins of the Drosha, Dicer and Argonaute families, are associated with the aging process, as well as with some age-related diseases and progeroid syndromes. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101087DOI Listing

New and Emerging Treatments for Inflammatory Itch.

Ann Allergy Asthma Immunol 2020 Jun 1. Epub 2020 Jun 1.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO, 63110. Electronic address:

Objective: Chronic pruritus, or itch lasting >6 weeks, is a common symptom and has a profoundly negative impact on quality of life. While many primary dermatologic disorders such as atopic dermatitis and chronic urticaria are characterized by pruritus, numerous other allergic, hepatobiliary, lymphoproliferative, neurologic, and renal disorders are associated with chronic pruritus. Itch involves complex interactions orchestrated by a variety of factors released from and acting on the skin, immune system, and the sensory nervous system. Read More

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http://dx.doi.org/10.1016/j.anai.2020.05.028DOI Listing

Proceeding report of the fourth Symposium on Hidradenitis Suppurativa Advances (SHSA) 2019.

J Am Acad Dermatol 2020 Jun 1. Epub 2020 Jun 1.

The Rockefeller University, New York, NY.

The 4 Annual Symposium on Hidradenitis Suppurativa (SHSA) took place on 1-3 November 2019 at the Westin Book Cadillac Hotel in Detroit, Michigan, U.S.A. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.114DOI Listing

Beyond the term penetrating aortic ulcer: A morphologic descriptor covering a constellation of entities with different prognoses.

Prog Cardiovasc Dis 2020 Jun 1. Epub 2020 Jun 1.

Department of Pathology, Hospital Germans Trias i Pujol, Barcelona, Spain.

Penetrating aortic ulcer (AU) is defined as localized disruption of the intimal layer of the aortic wall, resulting in a crater-like lesion outpouching from the vessel contour. AU is a generic term which encompasses a constellation of entities with different etiologies and prognoses and may be a complication of infective, inflammatory, traumatic, iatrogenic, atherosclerotic processes or intramural hematoma. One of the most challenging scenarios of AU for a differential diagnosis, but also for treatment implications, is when they are associated with acute aortic syndrome. Read More

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http://dx.doi.org/10.1016/j.pcad.2020.05.006DOI Listing

Natural and forced neurogenesis in the adult brain: mechanisms and their possible application to treat neurological disorders.

Neurosci Res 2020 Jun 1. Epub 2020 Jun 1.

Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Neural stem cells (NSCs) in the adult hippocampus generate new neurons via a process referred to as neurogenesis, supporting cognitive functions. Since altered neurogenesis has been reportedly associated with several diseases such as epilepsy, the molecular basis of NSC activity is an important focus in the study of neurogenesis. Furthermore, facilitation of neurogenesis in the injured brain would be an ideal approach to replenish lost neurons for damage recovery. Read More

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http://dx.doi.org/10.1016/j.neures.2020.05.011DOI Listing

Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer.

J Control Release 2020 Jun 1. Epub 2020 Jun 1.

Institute of Biomedical Sciences, Research Center, Academia Sinica, Taipei 11529, Taiwan; the Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei 10051, Taiwan. Electronic address:

Lung cancer is the primary cause of cancer-related death worldwide. 85%-90% of cases are non-small cell lung cancer (NSCLC) which characteristically exhibits altered epidermal growth factor receptor (EGFR) signaling is a major driver pathway. Unfortunately, therapeutic outcomes in treating NSCLC are compromised by the emergence of drug resistance in response to EGFR-tyrosine kinase inhibitor (TKI) targeted therapy due to the acquired resistance mutation EGFR T790M or activation of alternative pathways. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.05.043DOI Listing

Thermally Activated Delayed Photoluminescence: Deterministic Control of Excited State Decay.

J Am Chem Soc 2020 Jun 4. Epub 2020 Jun 4.

Thermally activated photophysical processes are ubiquitous in numerous organic and metal-organic molecules, leading to chromophores with excited state properties that can be considered an equilibrium mixture of the available low-lying states. Relative populations of the equilibrated states are governed by temperature. Such molecules have been devised as high quantum yield emitters in modern organic light-emitting diode technology and for deterministic excited state lifetime control to enhance chemical reactivity in solar energy conversion and photocatalytic schemes. Read More

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http://dx.doi.org/10.1021/jacs.0c03331DOI Listing

On setting expectations for a SARS-CoV-2 Vaccine.

Clin Infect Dis 2020 Jun 4. Epub 2020 Jun 4.

Alpert Medical School and School of Public Health, Brown University, Providence Veteran Administration Medical Center, Providence, RI, U.S.A.

The global coronavirus pandemic is unlike any other since 1918. A century of dramatic medical advances has produced a public expectation that the medical field will rapidly provide solutions to restore normalcy. In under 6 months, since SARS-CoV-2 was identified, the massive international effort to develop a SARS-CoV-2 vaccine has generated more than 140 vaccines in different stages of development with 9 already recruiting into clinical trials posted on clinicaltrials. Read More

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http://dx.doi.org/10.1093/cid/ciaa726DOI Listing

G-OnRamp: Generating genome browsers to facilitate undergraduate-driven collaborative genome annotation.

PLoS Comput Biol 2020 Jun 4;16(6):e1007863. Epub 2020 Jun 4.

Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America.

Scientists are sequencing new genomes at an increasing rate with the goal of associating genome contents with phenotypic traits. After a new genome is sequenced and assembled, structural gene annotation is often the first step in analysis. Despite advances in computational gene prediction algorithms, most eukaryotic genomes still benefit from manual gene annotation. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007863DOI Listing

Exponential increase in mortality with age is a generic property of a simple model system of damage accumulation and death.

Authors:
Anders Ledberg

PLoS One 2020 4;15(6):e0233384. Epub 2020 Jun 4.

Department of Public Health Sciences, Stockholm University, Stockholm, Sweden.

The risk of dying increases exponentially with age, in humans as well as in many other species. This increase is often attributed to the "accumulation of damage" known to occur in many biological structures and systems. The aim of this paper is to describe a generic model of damage accumulation and death in which mortality increases exponentially with age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233384PLOS

Potent, specific MEPicides for treatment of zoonotic staphylococci.

PLoS Pathog 2020 Jun 4;16(6):e1007806. Epub 2020 Jun 4.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Coagulase-positive staphylococci, which frequently colonize the mucosal surfaces of animals, also cause a spectrum of opportunistic infections including skin and soft tissue infections, urinary tract infections, pneumonia, and bacteremia. However, recent advances in bacterial identification have revealed that these common veterinary pathogens are in fact zoonoses that cause serious infections in human patients. The global spread of multidrug-resistant zoonotic staphylococci, in particular the emergence of methicillin-resistant organisms, is now a serious threat to both animal and human welfare. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007806DOI Listing

Population density and habitat use of two sympatric small cats in a central Indian reserve.

PLoS One 2020 4;15(6):e0233569. Epub 2020 Jun 4.

Wildlife Institute of India, Dehradun, Uttarakhand, India.

Despite appreciable advances in carnivore ecology, studies on small cats remain limited with carnivore research in India being skewed towards large cats. Small cats are more specialized than their larger cousins in terms of resource selection. Studies on small cat population and habitat preference are critical to evaluate their status to ensure better management and conservation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233569PLOS

Anti-Insulin Receptor Antibodies in the Pathology and the Therapy of Diabetes Mellitus.

Curr Diabetes Rev 2020 Jun 4. Epub 2020 Jun 4.

Department of Biology, College of Science, The United Arab Emirates University (UAEU), PO Box 15551, Al Ain. United Arab Emirates.

Diabetes mellitus (DM) is recognized as the most common and the world's fastestgrowing chronic disease with severe complications leading to increased mortality. Many strategies exist for the management of DM and its control including treatment with insulin and insulin analogs, oral hypoglycemic therapy such as insulin secretion stimulators and insulin sensitizers, and diet and physical training. Over the years, many types of drugs and molecules with an interesting pharmacological diversity have been developed and proposed for their anti-diabetic potential. Read More

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http://dx.doi.org/10.2174/1573399816666200604122345DOI Listing

Current in vitro biofilm-infected chronic wound models for developing new treatment possibilities.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

University of Copenhagen, International Health, Immunology and Microbiology, Blegdamsvej 3b, opgang 24.1, Copenhagen, Denmark, DK-2200.

Significance: The prevalence of chronic wounds is increasing worldwide. The most recent estimates suggest that up to 2% of the population in the industrialized countries are affected.1 Recent Advances: During the past few decades, bacterial biofilms have been elucidated as one of the primary reasons why chronic wounds fail to heal. Read More

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http://dx.doi.org/10.1089/wound.2020.1176DOI Listing

Evidence-Based Review of Anti-Biofilm Agents for Wound Care.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

University of Miami Miller School of Medicine, 12235, Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, Miami, Florida, United States;

Significance Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. Biofilms attach to each other and to nearby surfaces. They are difficult to study and identify in a clinical setting as their quantification necessitates the use of advanced microscopy techniques such as confocal scanning laser microscopy (CLSM). Read More

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http://dx.doi.org/10.1089/wound.2020.1193DOI Listing

Approaches to modulate the chronic wound environment using localized nucleic acid delivery.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

Massachusetts Institute of Technology, 2167, Chemical Engineering, Cambridge, Massachusetts, United States.

Significance: Non-healing wounds have been the subject of decades of basic and clinical research. Despite new knowledge about the biology of impaired wound healing, little progress has been made in treating chronic wounds, leaving patients with few therapeutic options. Diabetic ulcers are a particularly common form of non-healing wound. Read More

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http://dx.doi.org/10.1089/wound.2020.1167DOI Listing

Diagnostics for Wound Infections.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

University of Texas at Arlington, 12329, Box 19138, Arlington, Texas, United States, 76019;

Significance: Infections can significantly delay the healing process in chronic wounds placing an enormous economic burden on health care resources. Identification of infection biomarkers and imaging modalities to observe and quantify them has seen progress over the years. Recent Advances: Traditionally, clinicians determine the presence of infection through visual observation of wounds and confirm their diagnosis through wound culture. Read More

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http://dx.doi.org/10.1089/wound.2019.1103DOI Listing

Architecture of Cancer-Associated Fibroblasts in Tumor Microenvironment: Mapping Their Origins, Heterogeneity, and Role in Cancer Therapy Resistance.

OMICS 2020 Jun;24(6):314-339

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

The tumor stroma, a key component of the tumor microenvironment (TME), is a key determinant of response and resistance to cancer treatment. The stromal cells, extracellular matrix (ECM), and blood vessels influence cancer cell response to therapy and play key roles in tumor relapse and therapeutic outcomes. Of the stromal cells present in the TME, much attention has been given to cancer-associated fibroblasts (CAFs) as they are the most abundant and important in cancer initiation, progression, and therapy resistance. Read More

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http://dx.doi.org/10.1089/omi.2020.0023DOI Listing

Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19.

Postgrad Med 2020 Jun 4. Epub 2020 Jun 4.

Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University , Xi'an 710061, China.

Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. Read More

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http://dx.doi.org/10.1080/00325481.2020.1778982DOI Listing

Systems Genetics for Mechanistic Discovery in Heart Diseases.

Circ Res 2020 Jun 4;126(12):1795-1815. Epub 2020 Jun 4.

From the Departments of Anesthesiology (C.D.R., Y.W.), David Geffen School of Medicine, University of California, Los Angeles.

Cardiovascular diseases are the leading cause of death worldwide. Complex diseases with highly heterogenous disease progression among patient populations, cardiovascular diseases feature multifactorial contributions from both genetic and environmental stressors. Despite significant effort utilizing multiple approaches from molecular biology to genome-wide association studies, the genetic landscape of cardiovascular diseases, particularly for the nonfamilial forms of heart failure, is still poorly understood. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315863DOI Listing

Challenges to reduce or replace NaCl by chloride salts in meat products made from whole pieces - a review.

Crit Rev Food Sci Nutr 2020 Jun 4:1-13. Epub 2020 Jun 4.

Faculdade de Engenharia de Alimentos, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.

NaCl is fundamental for the development of the physico-chemical, sensorial and microbiological stability in meat products made from whole pieces such as dry-cured lacón, loin, ham, bacon, jerked beef, and pastirma). The substitution of NaCl by other chloride salts (KCl, CaCl and MgCl), in order to minimize changes in the processing steps and insertion of new ingredients, is a major challenge for the elaboration of salted meat products in the context of increasing awareness among consumer about sodium consumption and health. This review aims to discuss the potential use of binary, ternary and quaternary salting mixtures in the processing of salted meat products and their effects on microbiological evolution and safety, sensory properties, oxidative reactions on proteins and lipid, and proteolysis and lipolysis reactions. Read More

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http://dx.doi.org/10.1080/10408398.2020.1774495DOI Listing

Hyperbaric storage at room like temperatures as a possible alternative to refrigeration: evolution and recent advances.

Crit Rev Food Sci Nutr 2020 Jun 4:1-12. Epub 2020 Jun 4.

QOPNA & LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal.

From 2012, the preservation of food products under pressure has been increasingly studied and the knowledge acquired has enlarged since several food products have been studied at different storage conditions. This new food preservation methodology concept called Hyperbaric Storage (HS) has gain relevance due to its potential as a replacement or an improvement to the conventional cold storage processes, such as the traditional refrigeration (RF), or even frosting, from the energetic savings to the reduction of the carbon foot-print. Briefly, HS is capable to inhibit the microbial proliferation or its inactivation which results in the extension of the shelf-life of several food products when compared to RF. Read More

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http://dx.doi.org/10.1080/10408398.2020.1770687DOI Listing

Harnessing Conformational Plasticity to Generate Designer Enzymes.

J Am Chem Soc 2020 Jun 4. Epub 2020 Jun 4.

Recent years have witnessed an explosion of interest in understanding the role of conformational dynamics in both the evolution of new enzymatic activities from existing enzymes, and in facilitating the emergence of enzymatic activity on scaffolds that were previously non-catalytic. There are also an increasing number of examples in the literature of targeted engineering of conformational dynamics being successfully used to alter enzyme selectivity and activity. Despite the obvious importance of conformational dynamics to both enzyme function and evolvability, many (although not all) computational design approaches still focus on either pure sequence-based approaches or on using structures with limited flexibility to guide the design. Read More

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http://dx.doi.org/10.1021/jacs.0c04924DOI Listing

[Cardiotoxicity of immune checkpoint inhibitors used in cancer treatment].

Rev Med Suisse 2020 Jun;16(696):1165-1168

Service de cardiologie, CHUV, 1011 Lausanne.

Immune checkpoint inhibitors (ICI) have revolutionized the field of oncology, by reshaping the prognosis of many cancers and are progressively becoming the standard of care. One of the costs of these advances is the emergence of a new spectrum of immune-related adverse events (irAEs), of which cardiovascular irAEs are particularly feared. ICI-induced myocarditis is often a diagnostic challenge because of the vast heterogeneity of clinical presentations, and it is associated with a high mortality rate of around 50%. Read More

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[Evolution of systemic anti-cancer therapies].

Rev Med Liege 2020 May;75(5-6):466-472

Service d'Oncologie médicale, CHU Liège, Belgique.

Before the advent of chemotherapy in the 1940s, cancer treatment was dominated by surgery and radiation therapy. The developments of targeted anti-cancer therapies in the 2000s followed by immunotherapy have largely changed the treatment landscape in particular in the metastatic setting. Here we provide a history of these advances. Read More

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[Novel drug targets and therapeutic perspectives. Towards a precision medicine].

Authors:
J Hanson

Rev Med Liege 2020 May;75(5-6):460-465

Laboratoire de Pharmacologie moléculaire, GIGA - Molecular Biology of Diseases, ULiège, Belgique.

A therapeutic target can be defined as the biochemical entity by which a drug exerts its beneficial effects. Historically, most drugs have been used without a precise knowledge of their mechanism of action. The rational drug design for a predefined target has been progressively implemented during the second half of the 20th century. Read More

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[Innovations in physical and rehabilitation medicine].

Rev Med Liege 2020 May;75(5-6):445-451

Service de Médecine Physique, Réadaptation et Traumatologie du Sport, CHU Liège, Belgique.

Over the last decade, Physical and Rehabilitation Medicine (PRM) is a medical specialty that has evolved considerably in the various fields that concern it : from the management of low back pain and lumbosciatalgia or osteoporosis in a multidisciplinary manner, through the use of new technologies in neuro-locomotor rehabilitation and robotisation in amputee patients for example, the development of regenerative medicine and prevention in sports traumatology and, finally, the progress of electrophysiology techniques for the diagnosis of small-fibre neuropathies. These various advances will be discussed in this article. Read More

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[What's new in diabetic retinopathy ?]

Rev Med Liege 2020 May;75(5-6):432-439

Service d'Ophtalmologie, CHU Liège, Belgique.

Diabetic retinopathy is a public health issue and the leading cause of blindness in adults in industrialized countries. Many advances have been made during the last few years in the diagnosis, the understanding of the pathophysiology and the treatment of diabetic retinopathy, especially with the rise of anti-angiogenic treatments. We bring here an overview of the last advances, the current therapeutic algorithms and future perspectives. Read More

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[Innovative therapeutic approaches in psychiatry : neuromodulation. For whom, why and how ?]

Rev Med Liege 2020 May;75(5-6):426-431

Service de Neurochirurgie, CHU Liège, Belgique.

Recent technological advances have seen the resumption or the advent of new approaches in the field of psychiatry such as electroconvulsive therapy, repeated transcranial magnetic stimulation, transcranial direct current electrical stimulation or even deep brain stimulation. These new approaches offer a window into the understanding of the neurobiological mechanisms linked to mental illnesses. This review summarizes current knowledges in the field and the future directions for the treatment of depression or obsessive-compulsive disorder. Read More

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[Current and new therapeutic options in inborn errors of metabolism].

Rev Med Liege 2020 May;75(5-6):420-425

Unité Métabolique, Service de Génétique, CHU Liège, Belgique.

Inborn errors of metabolism (IEM) represent a vast group of orphan genetic disorders associated with enzyme deficiencies, substrates accumulation and products depletion. For several decades, the cornerstone of life-saving therapies in IEM was based on extreme manipulations of the nutritional intakes. Such outstanding dietary engineering is still relevant today, but new therapeutic avenues have emerged last years, based on better pathophysiological understanding and technological advances. Read More

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[Therapeutic advances in neonatology].

Rev Med Liege 2020 May;75(5-6):415-419

Service de Néonatologie, CHU Liège, Belgique.

In this article, we will review major therapeutic advances in neonatology over the past ten years. We will discuss the antenatal administration of magnesium sulfate, the interest of hypothermia in the context of hypoxic ischaemic encephalopathy, the benefits and modalities of placental transfusion, less invasive techniques for ventilation and administration of the surfactant, possibilities to fortify breast milk and the concept of developmental care. These therapeutic advances are sometimes based on new therapeutics, sometimes on new concepts and, sometimes, on new less invasive techniques. Read More

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[Technological progress and novelty in insulin therapy during those last ten years for diabetes children and adolescents].

Rev Med Liege 2020 May;75(5-6):406-409

Service de Pédiatrie, CHU Liège, Belgique.

These last few years, new advances in technologies and modern insulin regimens have improved diabetes care for children and adolescents and have led to the definition of new therapeutic goals. Read More

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[Therapeutic and technological advances in the management of adult patients with type 1 diabetes].

Rev Med Liege 2020 May;75(5-6):399-405

Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Liège,Faculté de Médecine ULiège Belgique.

Management of type 1 diabetes remains a challenge. Indeed, many parameters can influence glycemia. Faced with this challenge, recent years have seen the emergence of various advances. Read More

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[Remarkable medical advances in rheumatology : may be…].

Rev Med Liege 2020 May;75(5-6):369-375

Clinical Trial Center, CHU Liège, Belgique.

The development of new drugs is a significant activity in a university hospital that favors access to therapeutic novelties to patients. Rheumatology, whose drug armamentarium was poor in the 1980s, has benefited from the huge progresses of immunology in the 1980-1990s, allowing a therapeutic revolution in whom the academic hospital of Liège (CHU Liège) has been strongly implicated. First protocols with anti-TNF-? monoclonal antibodies have been applied in 1997. Read More

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[Therapeutic innovation in nephrology : 10 years of progress].

Rev Med Liege 2020 May;75(5-6):336-343

Service de Néphrologie-Dialyse-Transplantation, CHU Liège, Belgique.

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression. During the past decade, a better understanding of the pathophysiological mechanisms of glomerular diseases has highlighted the benefits of rituximab. Read More

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[Hemophilia : a disease on the move].

Authors:
P Péters A Gothot

Rev Med Liege 2020 May;75(5-6):322-328

Service d'Hématologie biologique et Immunohématologie, CHU Liège, Belgique.

Over the last hundred years, the treatment of hemophilia has evolved considerably. To date, its principle is still to prevent the occurrence of hemorrhages by regular intravenous injections of factor VIII or IX concentrate. It allows to reach a life expectancy similar to the general population. Read More

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[Therapeutic revolution in heart failure].

Rev Med Liege 2020 May;75(5-6):304-309

Service de Cardiologie, GIGA Cardiovasculaire, CHU Liège, Belgique.

The introduction of basic treatment for heart failure dates to the late 1990s. Since that time, apart from a few new developments reserved for selected patients, there has been little progress. During these years, the epidemiology of the disease has evolved. Read More

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[Editorial. Therapeutic advances during the decade 2010-2020].

Authors:
A J Scheen

Rev Med Liege 2020 May;75(5-6):273-275

Professeur ordinaire honoraire, ULiège, Rédacteur de Chef de la Revue Médicale de Liège.

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Characterizing the Dynamics of Learning in Repeated Reference Games.

Cogn Sci 2020 Jun;44(6):e12845

Department of Psychology, Stanford University.

The language we use over the course of conversation changes as we establish common ground and learn what our partner finds meaningful. Here we draw upon recent advances in natural language processing to provide a finer-grained characterization of the dynamics of this learning process. We release an open corpus (>15,000 utterances) of extended dyadic interactions in a classic repeated reference game task where pairs of participants had to coordinate on how to refer to initially difficult-to-describe tangram stimuli. Read More

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http://dx.doi.org/10.1111/cogs.12845DOI Listing

Moving from "I know it when I see it" to an empirical classification of severe and enduring anorexia nervosa: Commentary on Wonderlich et al. (2020).

Int J Eat Disord 2020 Jun 4. Epub 2020 Jun 4.

Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, Illinois, USA.

Severe and enduring anorexia nervosa (SE-AN) is well known to clinicians who treat eating disorders, especially in adults, yet an empirically validated definition of SE-AN is lacking. Current approaches to delineating SE-AN rely on expert opinion, and there is little consensus regarding the criteria that distinguish SE-AN from other clinical presentations or the thresholds that define the boundaries of severity and enduringness. Empirical classification techniques and clinical staging frameworks that incorporate biomarkers offer intriguing alternatives to expert consensus in refining the definition of SE-AN. Read More

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http://dx.doi.org/10.1002/eat.23321DOI Listing

Diagnosis, Risk Stratification, and Treatment of Peripheral T-Cell Lymphomas: Past and Present.

Cancer J 2020 May/Jun;26(3):253-259

From the Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL.

Peripheral T-cell lymphomas represent an evolving class of aggressive T-cell malignancies that are generally refractory to conventional treatments and historically carry a poor prognosis. Recent advances in gene expression profiling have begun to unravel the specific molecular mechanisms of tumorigenesis in these disease processes, allowing for discrete classification schemes that help guide discussions regarding prognosis and therapy options. We outline here a review of the histopathology, epidemiology, clinical features, and treatment strategies currently used in the management of these diseases. Read More

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http://dx.doi.org/10.1097/PPO.0000000000000452DOI Listing

Central Nervous System Lymphoma: Approach to Diagnosis and Treatment.

Cancer J 2020 May/Jun;26(3):241-252

From the Department of Neurology, Memorial Sloan Kettering Cancer Center.

Central nervous system lymphoma (CNSL) is a rare form of extranodal non-Hodgkin lymphoma. Central nervous system lymphoma can be primary (isolated to the central nervous space) or secondary in the setting of systemic disease. Treatment of CNSL has improved since the introduction of high-dose methotrexate and aggressive consolidation regimens. Read More

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http://dx.doi.org/10.1097/PPO.0000000000000449DOI Listing

Advances in Treatment of Follicular Lymphoma.

Cancer J 2020 May/Jun;26(3):231-240

Department of Surgical, Medical and Dental Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Follicular lymphoma (FL) is a heterogeneous disease with varying prognosis owing to differences in clinical, laboratory, and disease parameters. Although generally considered incurable, prognosis for early and advanced stage disease has improved because of therapeutic advances, several of which have resulted from elucidation of the biologic and molecular basis of the disease. The choice of treatment for FL is highly dependent on patient and disease characteristics. Read More

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http://dx.doi.org/10.1097/PPO.0000000000000444DOI Listing

An Evaluation of Syndromic Surveillance-Related Practices Among Selected State and Local Health Agencies.

J Public Health Manag Pract 2020 Jun 2. Epub 2020 Jun 2.

Division of Health Informatics and Surveillance, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia.

Context: Syndromic surveillance consists of the systematic collection and use of near real-time data about health-related events for situational awareness and public health action. As syndromic surveillance programs continue to adopt new technologies and expand, it is valuable to evaluate these syndromic surveillance systems and practices to ensure that they meet public health needs.

Objective: This assessment's aim is to provide recent information about syndromic surveillance systems and practice characteristics among a group of state and local health departments. Read More

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http://dx.doi.org/10.1097/PHH.0000000000001216DOI Listing

A baculoviral system for the production of human β-glucocerebrosidase enables atomic resolution analysis.

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):565-580. Epub 2020 May 29.

Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, United Kingdom.

The lysosomal glycoside hydrolase β-glucocerebrosidase (GBA; sometimes called GBA1 or GC) catalyses the hydrolysis of glycosphingolipids. Inherited deficiencies in GBA cause the lysosomal storage disorder Gaucher disease (GD). Consequently, GBA is of considerable medical interest, with continuous advances in the development of inhibitors, chaperones and activity-based probes. Read More

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http://dx.doi.org/10.1107/S205979832000501XDOI Listing