Adv Immunol 2021 18;152:157-222. Epub 2021 Nov 18.
Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, United States; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, United States; Department of Pathology and Laboratory Medicine, University of California, Irvine, School of Medicine, Irvine, CA, United States. Electronic address:
The complement system was long considered as only a powerful effector arm of the immune system that, while critically protective, could lead to inflammation and cell death if overactivated, even in the central nervous system (CNS). However, in the past decade it has been recognized as playing critical roles in key physiological processes in the CNS, including neurogenesis and synaptic remodeling in the developing and adult brain. Inherent in these processes are the interactions with cells in the brain, and the cascade of interactions and functional consequences that ensue. Read More