250,712 results match your criteria Advances In Geophysics[Journal]


One panel to rule them all: DArTcap genotyping for population structure, historical demography, and kinship analyses, and its application to a threatened shark.

Mol Ecol Resour 2020 Jun 3. Epub 2020 Jun 3.

Research Institute for the Environment and Livelihoods, Charles Darwin University, Ellengowan Drive, Darwin, NT, 0909, Australia.

With recent advances in sequencing technology, genomic data are changing how important conservation management decisions are made. Applications such as Close-Kin Mark-Recapture demand large amounts of data to estimate population size and structure, and their full potential can only be realised through ongoing improvements in genotyping strategies. Here we introduce DArTcap, a cost-efficient method that combines DArTseq and sequence capture, and illustrate its use in a high resolution population analysis of Glyphis garricki, a rare, poorly known and threatened euryhaline shark. Read More

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http://dx.doi.org/10.1111/1755-0998.13204DOI Listing

P4-ATPases: how an old dog learnt new tricks - structure and mechanism of lipid flippases.

Curr Opin Struct Biol 2020 May 31;63:65-73. Epub 2020 May 31.

Aarhus University, Dept. Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic EMBL Partnership for Molecular Medicine, Denmark. Electronic address:

Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is essential for a wide range of cellular processes such as vesicle biogenesis and trafficking and membrane protein regulation, whereas dissipation of lipid asymmetry is required in blood coagulation and apoptosis. Through recent advances in cryo-electron microscopy, several landmark structures of yeast and human lipid flippases have been reported, highlighting the similarities and differences they share with the cation transporting P-type ATPases. Read More

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http://dx.doi.org/10.1016/j.sbi.2020.04.001DOI Listing

Recent advance in the biosynthesis of nitrogen-nitrogen bond-containing natural products.

Curr Opin Chem Biol 2020 May 16;59:62-68. Epub 2020 May 16.

Faculty of Pharmaceutical Sciences, Hokkaido University, Japan.

Nitrogen-nitrogen (N-N) bond-containing compounds are occasionally described in nature. Despite their interesting structural and biological features, biosynthetic machineries of N-N bond formation in nature remained undiscovered for a long time. However, the understanding on biosynthetic machineries of N-N bond formation have rapidly accumulated within the last few years. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.05.002DOI Listing

Unsupervised lesion detection via image restoration with a normative prior.

Med Image Anal 2020 May 1;64:101713. Epub 2020 May 1.

Computer Vision Laboratory, ETH Zürich, Sternwartstrasse 7, Zürich, 8092, Switzerland. Electronic address:

Unsupervised lesion detection is a challenging problem that requires accurately estimating normative distributions of healthy anatomy and detecting lesions as outliers without training examples. Recently, this problem has received increased attention from the research community following the advances in unsupervised learning with deep learning. Such advances allow the estimation of high-dimensional distributions, such as normative distributions, with higher accuracy than previous methods. Read More

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http://dx.doi.org/10.1016/j.media.2020.101713DOI Listing

Synthetic biology for protein-based materials.

Curr Opin Biotechnol 2020 May 31;65:197-204. Epub 2020 May 31.

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, People's Republic of China. Electronic address:

Recombinant protein polymers that mimic the structures and functions of natural proteins and those tailor-designed with new properties provide a family of uniquely tunable and functional materials. However, the diversity of genetically engineered protein polymers is still limited. As a powerful engine for the creation of new biological devices and systems, synthetic biology is promising to tackle the challenges that exist in conventional studies on protein polymers. Read More

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http://dx.doi.org/10.1016/j.copbio.2020.04.004DOI Listing

Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds.

Pharmacol Ther 2020 May 31:107593. Epub 2020 May 31.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China. Electronic address:

Cell death plays a critical role in organism development and the pathogenesis of diseases. Necrosis is considered a non-programmed cell death in an extreme environment. Recent advances have provided solid evidence that necrosis could be programmed and quite a few types of programmed necrosis, such as necroptosis, ferroptosis, pyroptosis, paraptosis, mitochondrial permeability transition-driven necrosis, and oncosis, have been identified. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2020.107593DOI Listing

Robotic intersphincteric resection with TME and coloanal anastomosis: a video vignette.

Colorectal Dis 2020 Jun 3. Epub 2020 Jun 3.

Division of Oncological and Robotic General Surgery, Careggi University Hospital, Florence, Italy.

The advances in oncology and the application of new technology in surgery have increased the use of sphincter-preserving procedures for the treatment of low rectal cancer. [1] Additionally, traditional ultralow anterior resection for rectal cancer results frequently in bowel, urinary and sexual dysfunctions. [2]. Read More

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http://dx.doi.org/10.1111/codi.15179DOI Listing

Transcriptional activities of human elongation factor-1α and cytomegalovirus promoter in transgenic dogs generated by somatic cell nuclear transfer.

PLoS One 2020 3;15(6):e0233784. Epub 2020 Jun 3.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seongbuk-gu, Seoul, Republic of Korea.

Recent advances in somatic cell nuclear transfer (SCNT) in canines facilitate the production of canine transgenic models. Owing to the importance of stable and strong promoter activity in transgenic animals, we tested human elongation factor 1α (hEF1α) and cytomegalovirus (CMV) promoter sequences in SCNT transgenic dogs. After transfection, transgenic donor fibroblasts with the hEF1α-enhanced green fluorescence protein (EGFP) transgene were successfully isolated using fluorescence-activated cell sorting (FACS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233784PLOS

Rethinking Space: A Review of Perception, Attention, and Memory in Scene Processing.

Annu Rev Vis Sci 2020 Jun 3. Epub 2020 Jun 3.

Department of Psychology, Queen's University, Kingston, Ontario K7L 3N6, Canada; email:

Scene processing is fundamentally influenced and constrained by spatial layout and spatial associations with objects. However, semantic information has played a vital role in propelling our understanding of real-world scene perception forward. In this article, we review recent advances in assessing how spatial layout and spatial relations influence scene processing. Read More

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http://dx.doi.org/10.1146/annurev-vision-121219-081745DOI Listing

Global Estimates and Long-Term Trends of Fine Particulate Matter Concentrations (1998-2018).

Environ Sci Technol 2020 Jun 3. Epub 2020 Jun 3.

Exposure to outdoor fine particulate matter (PM) is a leading risk factor for mortality. We develop global estimates of annual PM concentrations and trends for 1998-2018 using advances in satellite observations, chemical transport modeling, and ground-based monitoring. Aerosol optical depth (AOD) from advanced satellite products including finer resolution, increased global coverage, and improved long-term stability, are combined and related to surface PM concentrations using geophysical relationships between surface PM and AOD simulated by the GEOS-Chem chemical transport model with updated algorithms. Read More

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http://dx.doi.org/10.1021/acs.est.0c01764DOI Listing

Clinical Potential of UTE-MRI for Assessing COVID-19: Patient- and Lesion-Based Comparative Analysis.

J Magn Reson Imaging 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Background: Chest computed tomography (CT) has shown tremendous clinical potential for screening, diagnosis, and surveillance of COVID-19. However, safety concerns are warranted due to repeated exposure of X-rays over a short period of time. Recent advances in MRI suggested that ultrashort echo time MRI (UTE-MRI) was valuable for pulmonary applications. Read More

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http://dx.doi.org/10.1002/jmri.27208DOI Listing

Brønsted Acid-Catalysed Dehydrative Substitution Reactions of Alcohols.

Chemistry 2020 Jun 3. Epub 2020 Jun 3.

University of St Andrews, Chemistry, EaStCHEM School of Chemistry, University of St Andrews, North Haugh, KY16 9ST, St Andrews, UNITED KINGDOM.

The direct, catalytic dehydrative substitution of alcohols is a challenging, yet highly desirable process in the development of more sustainable approaches to organic chemistry. This review outlines recent advances in Brønsted acid-catalysed dehydrative substitution reactions for C-C, C-O, C-N and C-S bond formation. The wide range of processes that are now accessible using simple alcohols as the formal electrophile are highlighted, while current limitations and therefore possible future directions for research are also discussed. Read More

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http://dx.doi.org/10.1002/chem.202002106DOI Listing

One fly-one genome: chromosome-scale genome assembly of a single outbred Drosophila melanogaster.

Nucleic Acids Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.

A high quality genome assembly is a vital first step for the study of an organism. Recent advances in technology have made the creation of high quality chromosome scale assemblies feasible and low cost. However, the amount of input DNA needed for an assembly project can be a limiting factor for small organisms or precious samples. Read More

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http://dx.doi.org/10.1093/nar/gkaa450DOI Listing

Education in the genomics era: Generating high-quality genome assemblies in university courses.

Gigascience 2020 Jun;9(6)

LOEWE-Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.

Recent advances in genome sequencing technologies have simplified the generation of genome data and reduced the costs for genome assemblies, even for complex genomes like those of vertebrates. More practically oriented genomic courses can prepare university students for the increasing importance of genomic data used in biological and medical research. Low-cost third-generation sequencing technology, along with publicly available data, can be used to teach students how to process genomic data, assemble full chromosome-level genomes, and publish the results in peer-reviewed journals, or preprint servers. Read More

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http://dx.doi.org/10.1093/gigascience/giaa058DOI Listing

Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity.

Gigascience 2020 Jun;9(6)

Department of Computational Medicine, University of California, Los Angeles, 621 Charles E Young Dr S, Los Angeles, CA, 90095, USA.

Background: Consecutive testing of single nucleotide polymorphisms (SNPs) is usually employed to identify genetic variants associated with complex traits. Ideally one should model all covariates in unison, but most existing analysis methods for genome-wide association studies (GWAS) perform only univariate regression.

Results: We extend and efficiently implement iterative hard thresholding (IHT) for multiple regression, treating all SNPs simultaneously. Read More

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http://dx.doi.org/10.1093/gigascience/giaa044DOI Listing

New Coronavirus (SARS-CoV-2): advances to flatten the curve the prison population.

Rev Soc Bras Med Trop 2020 20;53:e20200219. Epub 2020 May 20.

Programa de Pós-Graduação Stricto Sensu em Cuidado em Enfermagem, Universidade Federal de Goiás, Goiânia, GO, Brasil.

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http://dx.doi.org/10.1590/0037-8682-0219-2020DOI Listing

Artificial Intelligence in Cardiology: Concepts, Tools and Challenges - "The Horse is the One Who Runs, You Must Be the Jockey".

Arq Bras Cardiol 2020 Apr 29;114(4):718-725. Epub 2020 May 29.

Universidade Federal Fluminense, Niterói, RJ, Brasil.

The recent advances at hardware level and the increasing requirement of personalization of care associated with the urgent needs of value creation for the patients has helped Artificial Intelligence (AI) to promote a significant paradigm shift in the most diverse areas of medical knowledge, particularly in Cardiology, for its ability to support decision-making and improve diagnostic and prognostic performance. In this context, the present work does a non-systematic review of the main papers published on AI in Cardiology, focusing on its main applications, potential impacts and challenges. Read More

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http://dx.doi.org/10.36660/abc.20180431DOI Listing

AutoProteome Chip System for Fully Automated and Integrated Proteomics Sample Preparation and Peptide Fractionation.

Anal Chem 2020 Jun 3. Epub 2020 Jun 3.

With recent advances in LC-MS systems, current MS-based proteomics has an increasing need for automated, high-throughput sample preparation with neglectable sample loss. In this study, we developed a microfluidic system for fully automated proteomics sample preparation. All of the required proteomics sample preparation steps for both protein digestion and peptide fractionation are fully integrated into a disposable plastic chip device (named AutoProteome Chip). Read More

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http://dx.doi.org/10.1021/acs.analchem.0c00752DOI Listing

Depletion of Lubricant from Nanostructured Oil-Infused Surfaces by Pendant Condensate Droplets.

ACS Nano 2020 Jun 3. Epub 2020 Jun 3.

Due to recent advances in nanofabrication, phase-change condensation heat transfer has seen a renaissance. Compared to conventional heat transfer surfaces, nanostructured surfaces impregnated with chemically matched lubrication film (hereinafter referred to as "nanostructured lubricated surfaces") have been demonstrated to improve the vapor-side phase-change condensation heat transfer by facilitating droplet nucleation, growth and departure. While the presence of nanoscale roughness improves performance longevity by stabilizing the lubrication film via capillary forces, such enhancement is short-lived due to the eventual loss of lubrication oil by departing droplets. Read More

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http://dx.doi.org/10.1021/acsnano.9b10184DOI Listing

Remote C-C bond formation via visible light photoredox-catalyzed intramolecular hydrogen atom transfer.

Authors:
Hui Chen Shouyun Yu

Org Biomol Chem 2020 Jun 3. Epub 2020 Jun 3.

State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Carbon-carbon bonds comprise the major framework of organic molecules, rendering their formation one of the most fundamental transformations in synthetic organic chemistry. Visible light photoredox catalysis has recently been established as a powerful technique to construct molecular architectures that would otherwise be inaccessible under mild conditions. Photoredox catalysis combined with intramolecular hydrogen atom transfer (HAT) can serve as a unique tool for achieving remote C-C bond formation. Read More

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http://dx.doi.org/10.1039/d0ob00854kDOI Listing

Advances in the surgical treatment of esophageal cancer since 1965.

Ann Gastroenterol Surg 2020 May 14;4(3):243-249. Epub 2020 Apr 14.

Department of Frontier Surgery Graduate School of Medicine Chiba University Chiba Japan.

In Japan, the treatment of esophageal cancer has undergone significant development since the Japanese Society for Esophageal Diseases was established in 1965 by Doctors Komei Nakayama, Shigetsugu Katsura, and Ichiro Akakura. When the Society was established, surgery was the first-line treatment for esophageal cancer. Since then, the Society has been led by three successive chairpersons-Doctors Katsura, Nakayama, and Satoh. Read More

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http://dx.doi.org/10.1002/ags3.12332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240144PMC

Essential updates 2018/2019: Liver transplantation.

Ann Gastroenterol Surg 2020 May 25;4(3):195-207. Epub 2020 Feb 25.

Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan.

Among the recent topics in the field of liver transplantation (LT), one of the significant therapeutic breakthroughs is the introduction of direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) infection. With cure rates close to 100%, a better proportion of LT candidates and recipients can be cured of HCV infection by DAA therapies that are simple and well-tolerated. Other critical topics include the issue of indication of LT for patients with hepatocellular carcinoma, which has been continuously studied. Read More

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http://dx.doi.org/10.1002/ags3.12321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240140PMC

Conformable self-assembling amyloid protein coatings with genetically programmable functionality.

Sci Adv 2020 May 20;6(21):eaba1425. Epub 2020 May 20.

Materials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Functional coating materials have found broad technological applications in diverse fields. Despite recent advances, few coating materials simultaneously achieve robustness and substrate independence while still retaining the capacity for genetically encodable functionalities. Here, we report biofilm-inspired protein nanofiber coatings that simultaneously exhibit substrate independence, resistance to organic solvents, and programmable functionalities. Read More

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http://dx.doi.org/10.1126/sciadv.aba1425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239643PMC

Solution-Processed, Large-Area, Two-Dimensional Crystals of Organic Semiconductors for Field-Effect Transistors and Phototransistors.

ACS Cent Sci 2020 May 8;6(5):636-652. Epub 2020 May 8.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.

Organic electronics with π-conjugated organic semiconductors are promising candidates for the next electronics revolution. For the conductive channel, the large-area two-dimensional (2D) crystals of organic semiconductors (2DCOS) serve as useful scaffolds for modern organic electronics, benefiting not only from long-range order and low defect density nature but also from unique charge transport characteristic and photoelectrical properties. Meanwhile, the solution process with advantages of cost-effectiveness and room temperature compatibility is the foundation of high-throughput print electrical devices. Read More

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http://dx.doi.org/10.1021/acscentsci.0c00251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256937PMC

Caspase Dependent and Independent Anti-hematological Malignancy Activity of AMHA1 Attenuated Newcastle Disease Virus.

Int J Mol Cell Med 2019 ;8(3):211-223

Experimental Therapy Department, Iraqi Center for cancer and medical genetics research, Mustansiriyah University, Baghdad, Iraq.

Hematological malignancies remain one of the leading causes of death worldwide despite advances in cancer therapeutics. Newcastle disease virus (NDV) is a member of that elicits considerable interest as an anticancer agent because it can replicate up to 10 000 times faster in human cancer cells than in most normal cancer cells. Several NDV strains reportedly induce the cytolysis of cancerous cell lines. Read More

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http://dx.doi.org/10.22088/IJMCM.BUMS.8.3.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241843PMC
January 2019

Minimally invasive periodontal therapy.

J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):161-165. Epub 2020 Apr 19.

Department of Periodontology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, 110025, India.

Historically, surgical techniques were governed by specific incisions and surgical designs. With the advent of anesthesia, the complicated cases were managed but at the cost of the tissues leading to morbidities of various degrees. The innovations and the advances in the surgical techniques led to the ideology that surgeries could be done with minimal tissue manipulation and sacrifice. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254457PMC

Parkinson Disease and Orthostatic Hypotension in the Elderly: Recognition and Management of Risk Factors for Falls.

Aging Dis 2020 May 9;11(3):679-691. Epub 2020 May 9.

3University of South Florida Parkinson's Disease and Movement Disorders Center, Parkinson Foundation Center of Excellence, Tampa, FL 33613, USA.

Parkinson disease (PD) is often associated with postural instability and gait dysfunction that can increase the risk for falls and associated consequences, including injuries, increased burden on healthcare resources, and reduced quality of life. Patients with PD have nearly twice the risk for falls and associated bone fractures compared with their general population counterparts of similar age. Although the cause of falls in patients with PD may be multifactorial, an often under-recognized factor is neurogenic orthostatic hypotension (nOH). Read More

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http://dx.doi.org/10.14336/AD.2019.0805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220277PMC

Plasmacytoid dendritic cell biology and its role in immune-mediated diseases.

Clin Transl Immunology 2020 May 26;9(5):e1139. Epub 2020 May 26.

INSERM, Centre de Recherche Saint-Antoine (CRSA) Sorbonne Université Paris France.

Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and have been implicated in the initiation and development of many autoimmune and inflammatory diseases. This review summarises the latest advances in recent years in several aspects of pDC biology, with special focus on pDC heterogeneity, pDC development via the lymphoid pathway, and newly identified proteins/pathways involved in pDC trafficking, nucleic acid sensing and interferon production. Read More

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http://dx.doi.org/10.1002/cti2.1139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248678PMC

Recent trends in airway management.

F1000Res 2020 13;9. Epub 2020 May 13.

Department of General Anesthesiology, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

Clinical airway management continues to advance at a fast pace. To help update busy anesthesiologists, this abbreviated review summarizes notable airway management advances over the past few years. We briefly discuss advances in video laryngoscopy, in flexible intubation scopes, in jet ventilation, and in extracorporeal membrane oxygenation (ECMO). Read More

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http://dx.doi.org/10.12688/f1000research.21914.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222034PMC

Targeting the "PVR-TIGIT axis" with immune checkpoint therapies.

F1000Res 2020 13;9. Epub 2020 May 13.

Cancer Research Center of Marseille, INSERM U1068, CNRS U7258, Aix Marseille Université, Institut Paoli - Calmettes, Marseille, France.

Checkpoint inhibitors have become an efficient way to treat cancers. Indeed, anti-CTLA-4, anti-PD1, and anti-PDL-1 antibodies are now used as therapies for cancers. However, while these therapies are very efficient in certain tumors, they remain poorly efficient in others. Read More

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http://dx.doi.org/10.12688/f1000research.22877.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222031PMC

Within-season changes in habitat use of forest-dwelling boreal bats.

Ecol Evol 2020 May 13;10(9):4164-4174. Epub 2020 Apr 13.

Finnish Museum of Natural History University of Helsinki Helsinki Finland.

Bats utilize forests as roosting sites and feeding areas. However, it has not been documented how bats utilize these habitats in the boreal zone with methods afforded by recent technological advances. Forest structure and management practices can create a variety of three-dimensional habitats for organisms capable of flight, such as bats. Read More

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http://dx.doi.org/10.1002/ece3.6253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244798PMC

Self-Supervised Representation Learning for Ultrasound Video.

Proc IEEE Int Symp Biomed Imaging 2020 Apr;2020:1847-1850

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, UK.

Recent advances in deep learning have achieved promising performance for medical image analysis, while in most cases ground-truth annotations from human experts are necessary to train the deep model. In practice, such annotations are expensive to collect and can be scarce for medical imaging applications. Therefore, there is significant interest in learning representations from unlabelled raw data. Read More

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http://dx.doi.org/10.1109/ISBI45749.2020.9098666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266673PMC

Heart rate variability: Measurement and emerging use in critical care medicine.

J Intensive Care Soc 2020 May 11;21(2):148-157. Epub 2019 Jun 11.

University of Liverpool and The Royal Liverpool University Hospital, Liverpool Healthcare Partners, Liverpool, UK.

Variation in the time interval between consecutive R wave peaks of the QRS complex has long been recognised. Measurement of this RR interval is used to derive heart rate variability. Heart rate variability is thought to reflect modulation of automaticity of the sinus node by the sympathetic and parasympathetic components of the autonomic nervous system. Read More

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http://dx.doi.org/10.1177/1751143719853744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238479PMC

Recent advances in mass spectrometry based clinical proteomics: applications to cancer research.

Clin Proteomics 2020 24;17:17. Epub 2020 May 24.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Cancer biomarkers have transformed current practices in the oncology clinic. Continued discovery and validation are crucial for improving early diagnosis, risk stratification, and monitoring patient response to treatment. Profiling of the tumour genome and transcriptome are now established tools for the discovery of novel biomarkers, but alterations in proteome expression are more likely to reflect changes in tumour pathophysiology. Read More

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http://dx.doi.org/10.1186/s12014-020-09283-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247207PMC

Progress of ethylene action mechanism and its application on plant type formation in crops.

Saudi J Biol Sci 2020 Jun 3;27(6):1667-1673. Epub 2020 Jan 3.

CIMMYT-China Specialty Maize Research Center, Crop Breeding and Cultivation Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.

The plant hormone ethylene exerts a huge influence in the whole life cycle of plants, especially stress-resistance responses. With the development of functional genomics, that the action mechanism of ethylene takes part in mediated plant architecture has been clarified gradually, such as plant roots, stems, leaves, fiber elongation and so on. Accordingly, the application of ethylene on crops chemical control and genetic improvement is greatly expanded. Read More

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http://dx.doi.org/10.1016/j.sjbs.2019.12.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253889PMC

Canadian consensus: a new systemic treatment algorithm for advanced mutated non-small-cell lung cancer.

Curr Oncol 2020 Apr 1;27(2):e146-e155. Epub 2020 May 1.

William Osler Health System, University of Toronto, Brampton, ON.

Background: Multiple clinical trials for the treatment of advanced mutated non-small-cell lung cancer (nsclc) have recently been reported. As a result, the treatment algorithm has changed, and many important clinical questions have been raised:■ What is the optimal first-line treatment for patients with mutated nsclc?■ What is preferred first-line treatment for patients with brain metastasis?■ What is the preferred second-line treatment for patients who received first-line first- or second-generation tyrosine kinase inhibitors (tkis)?■ What is the preferred treatment after osimertinib?■ What evidence do we have for treating patients whose tumours harbour uncommon mutations?

Methods: A Canadian expert panel was convened to define the key clinical questions, review recent evidence, and discuss and agree on practice recommendations for the treatment of advanced mutated nsclc.

Results: The published overall survival results for osimertinib, combined with its central nervous system activity, have led to osimertinib becoming the preferred first-line treatment for patients with common mutations, including those with brain metastasis. Read More

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http://dx.doi.org/10.3747/co.27.6007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253730PMC

Longitudinal Analysis of Gene Expression Changes During Cervical Carcinogenesis Reveals Potential Therapeutic Targets.

Evol Bioinform Online 2020 18;16:1176934320920574. Epub 2020 May 18.

Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, China.

Despite advances in the treatment of cervical cancer (CC), the prognosis of patients with CC remains to be improved. This study aimed to explore candidate gene targets for CC. CC datasets were downloaded from the Gene Expression Omnibus database. Read More

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http://dx.doi.org/10.1177/1176934320920574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241206PMC

Contemporary x-ray wavelength metrology and traceability.

Radiat Phys Chem Oxf Engl 1993 2020 Feb 3;167. Epub 2019 Jul 3.

National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, MD, 20899, USA.

We report recent advances in absolute x-ray wavelength metrology in the context of producing modern standard reference data. Primary x-ray wavelength standards are produced today using diffraction spectrometers using crystal optics arranged to be operated in dispersive and non-dispersive geometries, giving natural-line-width limited profiles with high resolution and accuracy. With current developments, measurement results can be made traceable to the definition of the meter by using diffraction crystals that have absolute lattice-spacing provenance through x-ray-optical interferometry. Read More

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http://dx.doi.org/10.1016/j.radphyschem.2019.108392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266105PMC
February 2020

Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture after Myocardial Infarction.

Circulation 2020 Jun 3. Epub 2020 Jun 3.

Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA.

Cardiac rupture is a major lethal complication of acute myocardial infarction (MI). Despite significant advances in reperfusion strategies, mortality from cardiac rupture remains high. Studies suggest that cardiac rupture can be accelerated by thrombolytic therapy, but the relevance of this risk factor remains controversial. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044340DOI Listing

Palliative Care for the Asian American Adult Population: A Scoping Review.

Am J Hosp Palliat Care 2020 Jun 3:1049909120928063. Epub 2020 Jun 3.

Health Sciences and Human Services Library, University of Maryland, Baltimore, MD, USA.

Background: The Asian American (AA) population is rapidly becoming one of the largest racial/ethnic groups in the United States. Despite this growth and advances in palliative care (PC) programs in the United States, the scope and nature of the literature regarding PC for AAs remains unclear. This review provides an overview of existing research on PC for AAs, identifies gaps in the research with recommendations for future research and delineates practice implications. Read More

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http://dx.doi.org/10.1177/1049909120928063DOI Listing