229,678 results match your criteria Advances In Geophysics[Journal]


Basophil involvement in lupus nephritis: a basis for innovation in daily care.

Nephrol Dial Transplant 2018 Jul 25. Epub 2018 Jul 25.

Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252, Université Paris Diderot, Sorbonne Paris Cité, Faculté de Médecine site Bichat, Laboratoire d'Excellence Inflamex, DHU FIRE, Paris, France.

Lupus nephritis (LN) affects a large proportion of patients with systemic lupus erythematosus (SLE). LN can lead to end-stage renal disease depending on when it is diagnosed and on the adequacy of the treatment administered to the patient based on the class of LN. Determination of the class and activity of LN is only possible by histological analysis of kidney biopsies. Read More

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http://dx.doi.org/10.1093/ndt/gfy245DOI Listing

Antibacterial activity study of 1,2,4-triazole derivatives.

Eur J Med Chem 2019 Apr 16;173:274-281. Epub 2019 Apr 16.

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, PR China. Electronic address:

Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.043DOI Listing

Role of nuclear RNA in regulating chromatin structure and transcription.

Curr Opin Cell Biol 2019 Apr 19;58:120-125. Epub 2019 Apr 19.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

The importance of three-dimensional chromatin organisation in genome regulation has never been clearer. But in spite of the enormous technological advances to probe chromatin organisation in vivo, there is still a lack of mechanistic understanding of how such an arrangement is achieved. Here we review emerging evidence pointing to an intriguing role of nuclear RNA in shaping large-scale chromatin structure and regulating genome function. Read More

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http://dx.doi.org/10.1016/j.ceb.2019.03.007DOI Listing

Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy.

Drug Discov Today 2019 Apr 19. Epub 2019 Apr 19.

Centre for Biosystems and Genome Network Medicine, Ioannina University, Ioannina, Greece; Department of Surgery, Ioannina University Hospital, Ioannina, Greece; Department of Systems Biology, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. Electronic address:

Progress in understanding and overcoming fatal intrinsic and acquired resistance is slow, with only a few exceptions. Despite advances in modern genome and transcriptome analysis, the controversy of the three different theories on drug resistance and tumor progression, namely dynamic intratumor heterogeneity, pre-existing minor genomic clones and tumor ecosystem, is unresolved. Moreover, evidence on transcriptional heterogeneity suggests the necessity of a drug bank for individualized, precise drug-sensitivity prediction. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.04.008DOI Listing

Recent advances in gelatin-based therapeutics.

Expert Opin Biol Ther 2019 Apr 22. Epub 2019 Apr 22.

a NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7 , Vitoria-Gasteiz 01006 , Spain .

Introduction: Biomaterials have provided a wide range of exciting opportunities in tissue engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has been extensively used in regenerative medicine applications over the years, due to its cell-responsive properties and the capacity to deliver a wide range of biomolecules. Areas covered: The most relevant properties of gelatin as biomaterial are presented together with its main therapeutic applications. Read More

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http://dx.doi.org/10.1080/14712598.2019.1610383DOI Listing

Uncommon Histopathological Variants of Malignant Melanoma. Part 2.

Am J Dermatopathol 2019 May;41(5):321-342

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Despite new horizons opened by recent advances in molecular pathology, histological evaluation still remains the diagnostic gold standard regarding cutaneous melanocytic neoplasms. Several histological variants of melanoma have been described, and their knowledge is crucial for accurate diagnosis and classification of cases with unusual clinico-pathological features. Uncommon histological variants of melanoma have been described based on a broad constellation of features, including architectural pattern, stromal alterations, cytological attributes, and other morphological properties. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001226DOI Listing

Machine Learning and Deep Neural Networks in Thoracic and Cardiovascular Imaging.

J Thorac Imaging 2019 May;34(3):192-201

Department of Radiology, University of California San Diego.

Advances in technology have always had the potential and opportunity to shape the practice of medicine, and in no medical specialty has technology been more rapidly embraced and adopted than radiology. Machine learning and deep neural networks promise to transform the practice of medicine, and, in particular, the practice of diagnostic radiology. These technologies are evolving at a rapid pace due to innovations in computational hardware and novel neural network architectures. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000385DOI Listing

Environmental DNA Shaping A New Era of Ecotoxicological Research.

Authors:
Xiaowei Zhang

Environ Sci Technol 2019 Apr 22. Epub 2019 Apr 22.

Aquatic ecosystems, such as rivers and lakes, are exposed to multiple stressors from anthropogenic activity and changes in climate, which have resulted in a general decrease in biodiversity, alteration of community structures, and can ultimately result in reduction of resources provided by natural ecosystems. Adverse outcomes caused by pollutants to ecosystems are determined not only by toxic properties, but also ecological contexts of ecosystems, including indigenous biodiversity and community composition. It is therefore important to identify key factors, such as diversity of species and traits that determine the vulnerability of structures and functions of ecosystems in response to toxic substances. Read More

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http://dx.doi.org/10.1021/acs.est.8b06631DOI Listing

Challenges for Exposure Science in Developing Countries.

Authors:
Saloshni Naidoo

Ann Work Expo Health 2019 Apr 22. Epub 2019 Apr 22.

Discipline of Public Health Medicine, School of Nursing and Public Health, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Occupational and environmental exposures are important contributors influencing the burden of disease in developing countries. It is important to quantify the impact of exposures from working and living environments on individual and population health in order to reduce the burden of related diseases. Despite the tremendous advances made internationally in the field of exposure science, numerous challenges, including low literacy levels, poor organization of work and living, legislative gaps, and limited exposure science capacity, exist in developing countries. Read More

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http://dx.doi.org/10.1093/annweh/wxz029DOI Listing

The clinical efficacy and safety of the Chinese herbal medicine Astragalus (Huangqi) preparation for the treatment of acute myocardial infarction: A systematic review of randomized controlled trials.

Medicine (Baltimore) 2019 Apr;98(16):e15256

School of Chinese Medicine.

Background: In recent years, with the enormous advances in the field of cardiac intervention technology, the survival rate of patients with acute myocardial infarction (AMI) has been improved significantly. However, the risk of arrhythmias and heart failure remains very high in AMI patients for long-term prognosis. Chinese herbal medicine (CHM) is more and more used in the treatment of AMI because of its good curative effect and less side effects. Read More

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http://dx.doi.org/10.1097/MD.0000000000015256DOI Listing

New approach for investigating neuropathic allodynia by optogenetics.

Authors:
Makoto Tsuda

Pain 2019 May;160 Suppl 1:S53-S58

Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Mechanical allodynia is pain caused by normally innocuous mechanical stimuli and is a cardinal and intractable symptom of neuropathic pain. Roles of low-threshold mechanoreceptors (LTMRs), including Aβ fibers, in mechanical allodynia have previously been proposed, but the necessity and sufficiency of LTMRs in allodynia have not been fully determined. Recent technological advances have made it possible to achieve subpopulation-specific ablation, silencing or stimulation, and to dissect and elucidate complex neuronal circuitry. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001506DOI Listing
May 2019
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Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain.

Pain 2019 May;160 Suppl 1:S37-S48

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

This review expounds on types and properties of biomarkers for chronic pain, given a mechanistic model of processes underlying development of chronic pain. It covers advances in the field of developing biomarkers for chronic pain, while outlining the general principles of categorizing types of biomarkers driven by specific hypotheses regarding underlying mechanisms. Within this theoretical construct, example biomarkers are described and their properties expounded. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001529DOI Listing

Structure-function relationships in peripheral nerve contributions to diabetic peripheral neuropathy.

Pain 2019 May;160 Suppl 1:S29-S36

Department of Molecular Pharmacology, Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.

Diabetes mellitus (DM) is a major global health concern, affecting more than 9% of the world population. The most common complication of DM is diabetic peripheral neuropathy (DPN), which leads to neuropathic pain in as many as 50% of patients. Despite its prevalence, there is neither good prevention of nor treatments for DPN, representing a major gap in care for the many who are afflicted. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001530DOI Listing

Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats.

Anesthesiology 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

What We Already Know About This Topic: Opioid-induced respiratory depression results in part from direct activation of μ-opioid receptors expressed in the inspiratory rhythm generator located in the ventrolateral medulla, the preBötzinger ComplexRespiratory neurons within the medulla also express nicotinic acetylcholine receptors, which are made up of five subunits, arranged symmetrically around a central poreActivation of the nicotinic acetylcholine receptor α4, α7, and β2 subunits increases respiratory rhythm, whereas activation of the nicotinic acetylcholine receptor α4β2 or α7 subunits induces analgesia in multiple forms of pain WHAT THIS ARTICLE TELLS US THAT IS NEW: The nonselective nicotinic acetylcholine receptor agonist nicotine and the α4β2 nicotinic acetylcholine receptor agonist A85380, but not the α7 nicotinic acetylcholine receptor agonist PNU282987, reversed respiratory depression induced by activation of μ-opioid receptors in rats both in vitro and in vivoCoadministration of A85380 with fentanyl not only markedly reduced respiratory depression and apneas but also enhanced the fentanyl-induced analgesia BACKGROUND:: Opioid analgesics are widely used for treatment of acute, postoperative, and chronic pain. However, activation of opioid receptors can result in severe respiratory depression. There is an unmet clinical need to develop a pharmacologic therapy to counter opioid-induced respiratory depression without interfering with analgesia. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002676DOI Listing

Calciphylaxis: Diagnosis, Pathogenesis, and Treatment.

Authors:
John J Chang

Adv Skin Wound Care 2019 May;32(5):205-215

John J. Chang, MD • Assistant Professor • Department of Internal Medicine • Yale School of Medicine, New Haven, Connecticut.

General Purpose: To provide information on the pathogenesis, clinical features, diagnosis, and treatment of calciphylaxis.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant should be better able to:1. Read More

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http://dx.doi.org/10.1097/01.ASW.0000554443.14002.13DOI Listing

Pressure Injuries: Nursing-Sensitive Indicator or Team- and Systems-Sensitive Indicator?

Adv Skin Wound Care 2019 May;32(5):199-200

Elizabeth A. Ayello, PhD, RN, CWON, ETN, MAPWCA, FAAN, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Faculty, Excelsior College School of Nursing, Albany, New York; President, World Council of Enterostomal Therapists, President, Ayello Harris & Associates, Inc, Copake, New York; and President (1999), National Pressure Ulcer Advisory Panel. R. Gary Sibbald, MD, DSc (Hons), MEd, BSc, FRCPC (Med Derm), FAAD, MAPWCA, JM, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Professor, Medicine and Public Health, University of Toronto, Ontario, Canada; Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana Faculty of Public Health, University of Toronto; and President (2008-2012), World Union of Wound Healing Societies.

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http://dx.doi.org/10.1097/01.ASW.0000557754.10070.88DOI Listing

The meaning of donor-specific antibodies after heart transplant.

Curr Opin Organ Transplant 2019 Apr 16. Epub 2019 Apr 16.

Medical University of Vienna, Department of Cardiac Surgery, Vienna, Austria.

Purpose Of Review: Antibody-mediated rejection (AMR) is a major contributor of impaired long-term survival after heart transplantation (HTx). The presence of circulating donor-specific antihuman leukocyte antigen (HLA) antibodies (DSAs) is considered as a mandatory criterion for AMR after HTx. DSA are known prognostic biomarkers of outcome, for example, recipients with de-novo DSA have a three-fold increased risk of mortality. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000641DOI Listing

Drug discovery strategies for acute radiation syndrome.

Expert Opin Drug Discov 2019 Apr 22:1-15. Epub 2019 Apr 22.

b Scientific Research Department , Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences , Bethesda , MD , USA.

Introduction: There are at the minimum two major, quite different approaches to advance drug discovery. The first being the target-based drug discovery (TBDD) approach that is commonly referred to as the molecular approach. The second approach is the phenotype-based drug discovery (PBDD), also known as physiology-based drug discovery or empirical approach. Read More

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http://dx.doi.org/10.1080/17460441.2019.1604674DOI Listing

Floral colour structure in two Australian herbaceous communities: it depends on who is looking.

Ann Bot 2019 Apr 22. Epub 2019 Apr 22.

School of Biological Sciences, Monash University, Melbourne, Australia.

Background And Aims: Pollinator-mediated interactions between plant species may affect the composition of angiosperm communities. Floral colour signals should play a role in these interactions, but the role will arise from the visual perceptions and behavioural responses of multiple pollinators. Recent advances in the visual sciences can be used to inform our understanding of these perceptions and responses. Read More

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http://dx.doi.org/10.1093/aob/mcz043DOI Listing

Joint linkage and association mapping of complex traits in shrub willow (Salix purpurea L.).

Ann Bot 2019 Apr 22. Epub 2019 Apr 22.

Horticulture Section, School of Integrative Plant Science, Cornell University, Cornell AgriTech, Geneva, NY, USA.

Background And Aims: Increasing energy demands and the necessity to reduce greenhouse gas emissions are key motivating factors driving the development of lignocellulosic crops as an alternative to non-renewable energy sources. The effects of global climate change will require a better understanding of the genetic basis of complex adaptive traits to breed more resilient bioenergy feedstocks, like willow (Salix spp.). Read More

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http://dx.doi.org/10.1093/aob/mcz047DOI Listing

[Advances in the roles and mechanisms of nonsense-mediated mRNA decay in embryonic development].

Sheng Li Xue Bao 2019 Apr;71(2):327-335

Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Nonsense-mediated mRNA decay (NMD) is originally identified as a widespread mRNA surveillance machinery in degrading 'aberrant' mRNA species with premature termination codons (PTCs) rapidly, which protects the cells from the accumulation of truncated proteins. Recent studies show that NMD can also regulate the degradation of normal gene transcripts, which execute important cellular and physiological functions. Therefore, NMD is considered as a highly conserved post-transcriptional regulatory mechanism in eukaryotes. Read More

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[Advances on the anti-inflammatory and protective effect of AMPK activators].

Sheng Li Xue Bao 2019 Apr;71(2):319-326

Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China.

AMP-activated protein kinase (AMPK) is a key enzyme in the regulation of cellular energy homeostasis. Recent studies demonstrated that AMPK also plays an important role in the modulation of inflammation, an energy-intensive molecular response. The commonly used AMPK activators include 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and A-769662. Read More

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[Research advances of autonomic nervous system in the regulation of cardiac inflammation].

Sheng Li Xue Bao 2019 Apr;71(2):225-234

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.

The autonomic nervous system consists of the sympathetic nervous system and the parasympathetic nervous system. These two systems control the heart and work in a reciprocal fashion to modulate myocardial energy metabolism, heart rate as well as blood pressure. Multiple cardiac pathological conditions are accompanied by autonomic imbalance, characterized by sympathetic overactivation and parasympathetic inhibition. Read More

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Gonadal Tissue Cryopreservation for a Girl With Partial Androgen Insensitivity Syndrome.

J Endocr Soc 2019 May 13;3(5):887-891. Epub 2019 Mar 13.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Individuals with differences/disorders of sex development (DSD) have increased rates of infertility. For children and youth undergoing prophylactic gonadectomy for malignancy risk, our institution offers gonadal tissue cryopreservation, an experimental technique to preserve fertility cryopotential. An 11-year-old girl with partial androgen insensitivity syndrome presented for evaluation for fertility preservation in the setting of a planned bilateral gonadectomy at an outside institution. Read More

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http://dx.doi.org/10.1210/js.2019-00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467392PMC

Functional Characterization of Glucocorticoid Receptor Variants Is Required to Avoid Misinterpretation of NGS Data.

J Endocr Soc 2019 May 6;3(5):865-881. Epub 2019 Mar 6.

INSERM UMR_S U1185, Fac Med Paris Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France.

Recent advances in genetic analysis technologies such as next-generation sequencing (NGS) have considerably increased the incidental discovery of genetic abnormalities. Six heterozygous missense mutations of the human glucocorticoid receptor (GR; encoded by the gene) have been identified in the context of genetic screening of endocrine pathologies. GR, a nuclear receptor, hormone-induced transcription factor, is involved in many physiological processes. Read More

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http://dx.doi.org/10.1210/js.2019-00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467410PMC

Tissue Destruction Caused by Parasite Cell Death, Inflammation, Invasion, and the Gut Microbiome.

Curr Clin Microbiol Rep 2019 21;6(1):51-57. Epub 2019 Jan 21.

1Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA USA.

Purpose Of Review: is a protozoan parasite that causes amebiasis, which remains a significant cause of morbidity and mortality worldwide. causes tissue destruction which leads to clinical disease. This review outlines some of the recent advances that have furthered our understanding of the processes that lead to the tissue damage caused by

Recent Findings: Recent studies have identified new mechanisms involved in -induced tissue damage. Read More

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http://link.springer.com/10.1007/s40588-019-0113-6
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http://dx.doi.org/10.1007/s40588-019-0113-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449278PMC
January 2019
1 Read

Earthquake Nucleation Size: Evidence of Loading Rate Dependence in Laboratory Faults.

J Geophys Res Solid Earth 2019 Jan 22;124(1):689-708. Epub 2019 Jan 22.

Department of Geosciences University of Padova Padova Italy.

Recent Global Positioning System observations of major earthquakes such as the 2014 Chile megathrust show a slow preslip phase releasing a significant portion of the total moment (Ruiz et al., 2014, https://doi.org/10. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1029/2018JB016803
Publisher Site
http://dx.doi.org/10.1029/2018JB016803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472498PMC
January 2019
1 Read

Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer.

Prostate Cancer 2019 17;2019:4047680. Epub 2019 Mar 17.

Department of Genetics, Louisiana State University Health Sciences Center, School of Medicine, 533 Bolivar St., New Orleans, LA 70112, USA.

Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA. Advances in high-throughput genotyping and next generation sequencing technologies have enabled discovery of germline genetic susceptibility variants and somatic mutations acquired during tumor formation. Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis. Read More

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https://www.hindawi.com/journals/pc/2019/4047680/
Publisher Site
http://dx.doi.org/10.1155/2019/4047680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441536PMC
March 2019
1 Read

Outcome and Complications of Combined Phacoemulsification and 23-Gauge Pars Plana Vitrectomy.

J Ophthalmol 2019 17;2019:7918237. Epub 2019 Mar 17.

Cukurova University, School of Medicine, Department of Ophthalmology, Adana, Turkey.

Background: With the advances in surgical tools, simultaneous removal of cataract associated with vitreoretinal disorders is gaining popularity. This combined surgery offers several advantages besides limitations. The aim of this study is to assess the outcome and complications of phacoemulsification combined with pars plana vitrectomy (PPV). Read More

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http://dx.doi.org/10.1155/2019/7918237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441543PMC

Informed Consent in Biomedical Research.

Comput Struct Biotechnol J 2019 25;17:463-474. Epub 2019 Mar 25.

Independent Scientist, Ottawa, Canada.

Informed consent is the result of tumultuous events in both the clinical and research arenas over the last 100 years. Throughout this time, the notion of informed consent has shifted tremendously, both due to advances in medicine, as well as the type of data being gathered. As such, informed consent has misaligned with the goals of medical research. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458444PMC

Biomedical applications of mRNA nanomedicine.

Nano Res 2018 Oct 27;11(10):5281-5309. Epub 2018 Jul 27.

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. Read More

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http://dx.doi.org/10.1007/s12274-018-2146-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472920PMC
October 2018

A Perspective on Recent Advances in Phosphorene Functionalization and Its Applications in Devices.

Eur J Inorg Chem 2019 Mar 21;2019(11-12):1476-1494. Epub 2018 Dec 21.

Consiglio Nazionale delle Ricerche - Istituto di Chimica dei Composti Organometallici Via Madonna del Piano 10 50019 Sesto Fiorentino, Florence Italy.

Phosphorene, the 2D material derived from black phosphorus, has recently attracted a lot of interest for its properties, suitable for applications in materials science. The physical features and the prominent chemical reactivity on its surface render this nanolayered substrate particularly promising for electrical and optoelectronic applications. In addition, being a new potential ligand for metals, it opens the way for a new role of the inorganic chemistry in the 2D world, with special reference to the field of catalysis. Read More

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http://dx.doi.org/10.1002/ejic.201801219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472490PMC

Photoactive Molecular-Based Devices, Machines and Materials: Recent Advances.

Eur J Inorg Chem 2018 Nov 22;2018(42):4589-4603. Epub 2018 Oct 22.

Istituto per la Sintesi Organica e la Fotoreattività Consiglio Nazionale delle Ricerche CLAN-Center for Light Activated Nanostructures Via Gobetti 101 40129 Bologna Italy.

Molecular and supramolecular-based systems and materials that can perform predetermined functions in response to light stimulation have been extensively studied in the past three decades. Their investigation continues to be a highly stimulating topic of chemical research, not only because of the inherent scientific value related to a bottom-up approach to functional nanostructures, but also for the prospective applications in diverse fields of technology and medicine. Light is an important tool in this context, as it can be conveniently used both for supplying energy to the system and for probing its states and transformations. Read More

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http://dx.doi.org/10.1002/ejic.201800923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472663PMC
November 2018

Scanning Microwave Microscopy of Vital Mitochondria in Respiration Buffer.

IEEE MTTS Int Microw Symp 2018 Jun 20;2018:115-118. Epub 2018 Aug 20.

Integrated Nanosystems Research Facility, University of California, Irvine, Irvine, CA 92697, USA.

We demonstrate imaging using scanning microwave microscopy (SMM) of vital mitochondria in respiration buffer. The mitochondria are isolated from cultured HeLa cells and tethered to a solid graphene support. The mitochondria are kept vital (alive) using a respiration buffer, which provides nutrients to sustain the Krebs cycle. Read More

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http://dx.doi.org/10.1109/MWSYM.2018.8439645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469850PMC

Recent advances in the development of polyethylenimine-based gene vectors for safe and efficient gene delivery.

Expert Opin Drug Deliv 2019 Apr 22:1-14. Epub 2019 Apr 22.

a Department of Pharmaceutics , China Pharmaceutical University , Nanjing , PR China.

Introduction: Despite the great therapeutic potential of gene therapy for treating critical diseases, the clinical application is limited by lack of safe and effective gene delivery vectors. Nonviral gene vectors have attracted tremendous attention due to the favorable loading capacity and facile manufacture. Among them, polyethylenimine-based gene vectors (PEIs) hold great promise for highly efficient gene delivery. Read More

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http://dx.doi.org/10.1080/17425247.2019.1604681DOI Listing

Educational attainment of childhood cancer survivors: A systematic review.

Cancer Med 2019 Apr 21. Epub 2019 Apr 21.

Institute of Health & Society, Newcastle University, Newcastle upon Tyne, United Kingdom.

Background: Advances in treatment mean that most children diagnosed with cancer during childhood survive. Therefore, it is increasingly important to examine the long-term consequences of childhood cancer, including educational attainment. This systematic review investigated whether the educational attainment of childhood cancer survivors differ from the cancer-free population. Read More

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http://dx.doi.org/10.1002/cam4.2154DOI Listing

Neuroimaging in alcohol use disorder: From mouse to man.

J Neurosci Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.

This article provides an overview of recent advances in understanding the effects of alcohol use disorders (AUD) on the brain from the perspective of magnetic resonance imaging (MRI) research in preclinical models and clinical studies. As a noninvasive investigational tool permitting assessment of morphological, metabolic, and hemodynamic changes over time, MRI offers insight into the dynamic course of alcoholism beginning with initial exposure through periods of binge drinking and escalation, sobriety, and relapse and has been useful in differential diagnosis of neurological diseases associated with AUD. Structural MRI has revealed acute and chronic effects of alcohol on both white and gray matter volumes. Read More

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http://dx.doi.org/10.1002/jnr.24423DOI Listing

miR-1285-3p is a potential prognostic marker in human osteosarcoma and functions as a tumor suppressor by targeting YAP1.

Cancer Biomark 2019 Apr 8. Epub 2019 Apr 8.

Background: Despite the major advances in the treatment, the overall survival of osteosarcoma remains poor. MicroRNAs (miRNAs) are involved in tumorigenesis and progression though modulating their target genes. In the present study, the roles of miR-1285-3p in osteosarcoma was investigated. Read More

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http://dx.doi.org/10.3233/CBM-180013DOI Listing

CRISPR in Parasitology: Not Exactly Cut and Dried!

Trends Parasitol 2019 Apr 18. Epub 2019 Apr 18.

INSERM, Unit U1201, Paris, France; Molecular Parasitology and Signaling Unit, Institut Pasteur, 75015 Paris, France.

CRISPR/Cas9 technology has been developing rapidly in the field of parasitology, allowing for the dissection of molecular processes with unprecedented efficiency. Optimization and implementation of a new technology like CRISPR, especially in nonmodel organisms, requires communication and collaboration throughout the field. Recently, a 'CRISPR in Parasitology' symposium was held at the Institut Pasteur Paris, bringing together scientists studying Leishmania, Plasmodium, Trypanosoma, and Anopheles. Read More

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http://dx.doi.org/10.1016/j.pt.2019.03.004DOI Listing

[Superficial angiomas: Treatment].

Presse Med 2019 Apr 18. Epub 2019 Apr 18.

Université François-Rabelais de Tours, centre hospitalier régional universitaire de Tours, service de neuroradiologie interventionnelle, 37000 Tours, France; Centre hospitalier régional universitaire de Tours, centre de référence des maladies rares de la peau et des muqueuses d'origine génétique (MAGEC), 37000 Tours, France.

Beta-blockers are efficient for treating complicated infantile hemangiomas; propranolol is currently the first-line treatment. Superficial vascular malformations have to be managed by multidisciplinary teams. T2 FAT-SAT MRI is the most interesting sequence to explore superficial vascular malformations. Read More

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http://dx.doi.org/10.1016/j.lpm.2019.03.010DOI Listing

The Spanish Network of Agencies for Health Technology Assessment and Services of the National Health System (RedETS).

Int J Technol Assess Health Care 2019 Apr 22:1-5. Epub 2019 Apr 22.

Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC).

Earlier activities on health technology assessment (HTA) started in Spain around 1984, with the creation of a National Advisory Board on HTA, and the development of national and regional HTA organizations in the early 1990s. In 2012, the Spanish Health Ministry established the Spanish Network for Health Technology Assessment of the National Health System (RedETS); funded at national level and including all public HTA organizations at national and regional levels. RedETSis focused on the assessment of nondrug health technologies to inform the revision (approval and funding or disinvestment) of the Benefit Portfolio of the Spanish NHS. Read More

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http://dx.doi.org/10.1017/S0266462319000205DOI Listing

Use of personal mobile devices to record patient data by Canadian emergency physicians and residents.

CJEM 2019 Apr 22:1-5. Epub 2019 Apr 22.

†Emergency Department,Vancouver General Hospital,Vancouver Coastal Health,Vancouver,BC.

Objective: Use of personal mobile devices to record patient data appears to be increasing, but remains poorly studied. We sought to determine the extent and reasons that Canadian emergency physicians (EPs) and emergency medicine residents use personal mobile devices to record patient data in the emergency department (ED).

Methods: A national survey was distributed to Canadian EPs and residents between 27/02/17 and 23/03/17. Read More

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http://dx.doi.org/10.1017/cem.2019.29DOI Listing

The Cognitive Lens: a primer on conceptual tools for analysing information processing in developmental and regenerative morphogenesis.

Philos Trans R Soc Lond B Biol Sci 2019 Jun;374(1774):20180369

Allen Discovery Center, Tufts University , Medford, MA 02155 , USA.

Brains exhibit plasticity, multi-scale integration of information, computation and memory, having evolved by specialization of non-neural cells that already possessed many of the same molecular components and functions. The emerging field of basal cognition provides many examples of decision-making throughout a wide range of non-neural systems. How can biological information processing across scales of size and complexity be quantitatively characterized and exploited in biomedical settings? We use pattern regulation as a context in which to introduce the Cognitive Lens-a strategy using well-established concepts from cognitive and computer science to complement mechanistic investigation in biology. Read More

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http://dx.doi.org/10.1098/rstb.2018.0369DOI Listing

Nipah virus: epidemiology, pathology, immunobiology and advances in diagnosis, vaccine designing and control strategies - a comprehensive review.

Vet Q 2019 Dec;39(1):26-55

k National Institute of Virology , Ministry of Health and Family Welfare, Govt of India , Pune , India.

Nipah (Nee-pa) viral disease is a zoonotic infection caused by Nipah virus (NiV), a paramyxovirus belonging to the genus Henipavirus of the family Paramyxoviridae. It is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly Pteropus spp. which are natural reservoir host. Read More

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December 2019

Tattoo removal by Q-switched Nd:YAG laser: an objective evaluation using histometry.

J Cosmet Laser Ther 2019 Apr 22:1-4. Epub 2019 Apr 22.

c Faculty of Medicine, Dermatology , Minia University , El Minia , Egypt.

Background: Tattoos have played an important role in various human cultures for thousands of years. The creation of high power, short pulse Q-switched lasers (QS) has provided a tool for considerable therapeutic advances in tattoo removal.

Objective: The aim of the study is to correlate the clinical efficacy of QS Nd: YAG laser for tattoo removal with histological as well as histometric findings. Read More

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http://dx.doi.org/10.1080/14764172.2019.1605451DOI Listing

Cardiovascular manifestations of sickle cell disease.

Eur Heart J 2019 Apr 21. Epub 2019 Apr 21.

Sorbonne Université, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), ACTION Study Group and Department of Cardiology, Institute of Cardiology (AP-HP), Hôpital Pitié- Salpêtrière, Boulevard de l'hôpital, Paris F-75013, France.

Sickle cell disease (SCD) is the most frequent genetic haemoglobinopathy worldwide. Early childhood mortality has dramatically decreased in high-income countries, and most patients now survive beyond the 5th decade. However, in the aging SCD population, the morbidity related to chronic organ damage, especially kidney and heart, has become a major concern. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz217DOI Listing

Leveraging anaerobic fungi for biotechnology.

Curr Opin Biotechnol 2019 Apr 18;59:103-110. Epub 2019 Apr 18.

Department of Agricultural and Biological Engineering, Purdue University, 225 South University Street, West Lafayette, IN 47907-2093, United States; Laboratory of Renewable Resources Engineering (LORRE), Purdue University, 500 Central Drive, West Lafayette, IN 47907-2022, United States; Purdue UniversityInterdisciplinary Life Sciences (PULSe) Program, Purdue University, 155 South Grant Street, West Lafayette, IN 47907-2114, United States. Electronic address:

Early-branching anaerobic fungi are critical for hydrolyzing untreated lignocellulose in the digestive tracts of large herbivorous animals. While these fungi were discovered more than 40 years ago, they remain understudied and underexploited. Recent advances in -omics technologies, however, have enabled studies that reveal significant biosynthetic potential within anaerobic fungal genomes for diverse biotechnological applications. Read More

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http://dx.doi.org/10.1016/j.copbio.2019.03.013DOI Listing

End-to-End Differentiable Learning of Protein Structure.

Cell Syst 2019 Mar 26. Epub 2019 Mar 26.

Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Predicting protein structure from sequence is a central challenge of biochemistry. Co-evolution methods show promise, but an explicit sequence-to-structure map remains elusive. Advances in deep learning that replace complex, human-designed pipelines with differentiable models optimized end to end suggest the potential benefits of similarly reformulating structure prediction. Read More

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http://dx.doi.org/10.1016/j.cels.2019.03.006DOI Listing

Single embryo transfer: Why and how to identify the embryo with the best developmental potential.

Authors:
Aila Tiitinen

Best Pract Res Clin Endocrinol Metab 2019 Apr 13. Epub 2019 Apr 13.

Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, FI-00029 Helsinki, Finland. Electronic address:

Multiple pregnancies with higher risk of preterm birth and the associated higher morbidity have been a major obstacle from the early days of in vitro fertilization. A good strategy to avoid multiple pregnancies is elective single embryo transfer and cryopreservation of spare embryos. Important factors in adopting this strategy are good counselling of the patients and the selection of embryos with high implantation potential. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X193001
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http://dx.doi.org/10.1016/j.beem.2019.04.001DOI Listing
April 2019
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Making Learning Fun: Gaming in Radiology Education.

Acad Radiol 2019 Apr 17. Epub 2019 Apr 17.

University of Utah Hospital, Salt Lake City, Utah. Electronic address:

With continued technologic advances, it is not surprising that gaming techniques are increasingly being used in radiology residency programs. This comprehensive review on gaming in radiology education offers insight into the importance of gaming, types of games and principles utilized in gaming, as well as applications that are inherent in artificial intelligence and continued medical education. The advantages and disadvantages of gaming will be considered, as well as barriers to successful adoption of gaming. Read More

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http://dx.doi.org/10.1016/j.acra.2019.02.020DOI Listing