252,728 results match your criteria Advances In Geometry[Journal]


Recent advances in single-molecule fluorescence microscopy render structural biology dynamic.

Curr Opin Struct Biol 2020 Jul 4;65:61-68. Epub 2020 Jul 4.

Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Electronic address:

Single-molecule fluorescence microscopy has long been appreciated as a powerful tool to study the structural dynamics that enable biological function of macromolecules. Recent years have witnessed the development of more complex single-molecule fluorescence techniques as well as powerful combinations with structural approaches to obtain mechanistic insights into the workings of various molecular machines and protein complexes. In this review, we highlight these developments that together bring us one step closer to a dynamic understanding of biological processes in atomic details. Read More

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http://dx.doi.org/10.1016/j.sbi.2020.05.006DOI Listing

Advances in menaquinone biosynthesis: sublocalisation and allosteric regulation.

Curr Opin Struct Biol 2020 Jul 4;65:33-41. Epub 2020 Jul 4.

Laboratory of Structural Biology, School of Biological Sciences and Maurice Wilkins Centre for MolecularBiodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand.

Menaquinones (vitamin K2) are a family of redox-active small molecules with critical functions across all domains of life, including energy generation in bacteria and bone health in humans. The enzymes involved in menaquinone biosynthesis also have bioengineering applications and are potential antimicrobial drug targets. New insights into the essential roles of menaquinones, and their potential to cause redox-related toxicity, have highlighted the need for this pathway to be tightly controlled. Read More

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http://dx.doi.org/10.1016/j.sbi.2020.05.005DOI Listing

Branching out: what omics can tell us about primate evolution.

Curr Opin Genet Dev 2020 Jul 4;62:65-71. Epub 2020 Jul 4.

Institute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain; Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, 08010, Barcelona, Spain; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Edifici ICTA-ICP, c/ Columnes s/n, 08193 Cerdanyola del Vallès, Barcelona, Spain. Electronic address:

The study of primate comparative genomics has long been a focus of research, particularly in the context of understanding human evolutionary history. Recently, high-throughput methods have become accessible that allow us to tackle these questions at scale by comparing genomes within and between species, or looking at gene regulatory and expression changes between species and tissues. This burst in large-scale genomic studies has drastically increased the resolution at which we are now able to understand the evolutionary forces acting upon our own species. Read More

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http://dx.doi.org/10.1016/j.gde.2020.06.006DOI Listing

Human pluripotent stem cells: A toolbox to understand and treat retinal degeneration.

Mol Cell Neurosci 2020 Jul 4:103523. Epub 2020 Jul 4.

INSERM U861, I-Stem, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, 91100 Corbeil-Essonnes, France; Université Paris-Saclay, Université d'Evry, U861, 91100 Corbeil-Essonnes, France; Centre d'Etude des Cellules Souches, 91100 Corbeil-Essonnes, France. Electronic address:

Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP) are retinal degenerative disorders that dramatically damage the retina. As there is no therapeutic options for the majority of patients, vision is progressively and irremediably lost. Owing to their unlimited renewal and potency to give rise to any cell type of the human adult body, human pluripotent stem cells (hPSCs) have been extensively studied in recent years to develop more physiologically relevant in vitro cellular models. Read More

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http://dx.doi.org/10.1016/j.mcn.2020.103523DOI Listing

Pharmacokinetic Investigation of Synthetic Cannabidiol Oral Formulations in Healthy Volunteers.

Eur J Pharm Biopharm 2020 Jul 4. Epub 2020 Jul 4.

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P.O.Box 12065, Jerusalem 91120, Israel. Electronic address:

Recent advances in the research of medicinal cannabis has placed the non-intoxicating cannabinoid cannabidiol (CBD) at the front of many investigations. The reasons behind this popularity is the compound's therapeutic properties, alongside a safe profile of administration lacking addictive properties such as euphoric state of mind and characterized with a wide dosing range. Oral administration of CBD is challenging due to poor solubility in the gastro-intestinal system and susceptibility to extensive first pass metabolism. Read More

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http://dx.doi.org/10.1016/j.ejpb.2020.06.021DOI Listing

Low bone mineral density in adults with complex congenital heart disease.

Int J Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Department of Public Health and Clinical Medicine, Umeå University, Sweden.

Aims: The majority of children with complex congenital heart disease (CHD) survive into adulthood due to advances in medical care. Adult patients with CHD have an increased incidence of diagnoses related to ageing such as heart failure, dementia, cancer and sarcopenia, despite a relatively low age. They also have a shorter life expectancy. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.053DOI Listing

A tetraprenylated benzophenone 7-epiclusianone induces cell cycle arrest at G1/S transition by modulating critical regulators of cell cycle in breast cancer cell lines.

Toxicol In Vitro 2020 Jul 4:104927. Epub 2020 Jul 4.

Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Minas Gerais, Brazil.. Electronic address:

Breast cancer is a complex disease and encompassing different types of tumor. Although advances in understanding of the molecular bases of breast cancer biology, the therapeutic proposals available still are not effective. In this scenario, the present study aimed to evaluate the mechanisms associated to antitumor activity of 7-Epiclusianone (7-Epi), a tetraprenylated benzopenone, on luminal A (MCF-7) and claudin-low (Hs 578 T) breast cancer cell lines. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104927DOI Listing

Updates in the treatment of Granulomatosis with Polyangiitis and Microscopic Polyangiitis.

Authors:
S Garner N Khalidi

Presse Med 2020 Jul 4:104038. Epub 2020 Jul 4.

McMaster University, Hamilton, Ontario, Canada.

There have been great advances in the management of ANCA associated vasculitis over the past decades. We have gone from an era where the disease was almost universally fatal to trying to prevent long term side effects of treatment regimens. With the ability to use pulse cyclophosphamide or rituximab as alternates to oral cyclophosphamide for induction of remission, side effects of therapy have been greatly reduced. Read More

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http://dx.doi.org/10.1016/j.lpm.2020.104038DOI Listing

A panel of circulating long non-coding RNAs as liquid biopsy biomarkers for breast and cervical cancers.

Biochimie 2020 Jul 4. Epub 2020 Jul 4.

Department of Zoology, Central University of Punjab, Bathinda, Punjab, India. Electronic address:

The early detection and diagnosis of cancer is critical to optimize the treatment and management of cancer patients. Typical methods such as imaging and tissue biopsy are invasive, time-consuming, and often imprecise. Thus, recent technological advances of dependable, facile, and minimally invasive collectible oncogenic biomarkers using human biofluids and secretions have been an active area of research. Read More

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http://dx.doi.org/10.1016/j.biochi.2020.06.012DOI Listing

The nuclear envelope: LINCing tissue mechanics to genome regulation in cardiac and skeletal muscle.

Biol Lett 2020 Jul 8;16(7):20200302. Epub 2020 Jul 8.

School of Cardiovascular Medicine and Sciences, King's College London, London SE5 9NU, UK.

Regulation of the genome is viewed through the prism of gene expression, DNA replication and DNA repair as controlled through transcription, chromatin compartmentalisation and recruitment of repair factors by enzymes such as DNA polymerases, ligases, acetylases, methylases and cyclin-dependent kinases. However, recent advances in the field of muscle cell physiology have also shown a compelling role for 'outside-in' biophysical control of genomic material through mechanotransduction. The crucial hub that transduces these biophysical signals is called the Linker of Nucleoskeleton and Cytoskeleton (LINC). Read More

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http://dx.doi.org/10.1098/rsbl.2020.0302DOI Listing

Electrocardiogram Standards for Children and Young Adults Using Z-scores.

Circ Arrhythm Electrophysiol 2020 Jul 7. Epub 2020 Jul 7.

Rady Children's Hospital San Diego & University of California San Diego, Department of Pediatrics, San Diego, CA.

- Normative ECG values for children are based on relatively few subjects and are not standardized, resulting in interpersonal variability of interpretation. Recent advances in digital technology allow a more quantitative, reproducible assessment of ECG variables. Our objective was to create the foundation of normative ECG standards in the young utilizing Z-scores. Read More

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http://dx.doi.org/10.1161/CIRCEP.119.008253DOI Listing

Recent Advances of Synthetic Macrocycle-Based Nonporous Adaptive Crystals for Molecular Separation.

Angew Chem Int Ed Engl 2020 Jul 7. Epub 2020 Jul 7.

Jilin University, College of Chemistry, 2699 Qianjin Street, 130012, Changchun, CHINA.

The exploitation of new materials for adsorptive separation of industrially important hydrocarbons is of great importance in both scientific research and petrochemical industry. Nonporous adaptive crystals (NACs) as a robust class of synthetic materials have drawn much attention during the past five years for their superior performance in adsorption and separation. Pillararenes are the main family of macrocyclic arenes used for NACs construction, where the structure-function relationship has been intensively studied. Read More

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http://dx.doi.org/10.1002/anie.202006999DOI Listing

Advances in Neurostimulation for Chronic Pain Disorders.

Pain Med 2020 Nov;21(7):1312-1314

Department of Pain Medicine, The James Cook University Hospital, Middlesbrough, UK.

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http://dx.doi.org/10.1093/pm/pnaa158DOI Listing
November 2020

Pediatric mental and behavioral health in the period of quarantine and social distancing (COVID-19).

Authors:
Jiancheng Ye

JMIR Pediatr Parent 2020 Jul 7. Epub 2020 Jul 7.

Northwestern University, 633 N. Saint Clair St, Chicago, US.

Unstructured: The COVID-19 pandemic has spread rapidly throughout the world and has generated a long-term impact. The pandemic has caused great harm to society and also caused serious psychological trauma to many people. Pediatrics are a vulnerable group in this global public health emergency, as their nervous systems, endocrine systems and hypothalamic-pituitary-adrenal axes are not well developed. Read More

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http://dx.doi.org/10.2196/19867DOI Listing

Immunosuppression in Visceral Transplantation: Current Trends and Future Perspectives.

Curr Pharm Des 2020 Jul 7. Epub 2020 Jul 7.

Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Fl. United States.

Visceral transplant represents an immunologic challenge due to high intestinal graft immunogenicity. Over the last 20 years, significant advances in immunosuppression regimens resulted in excellent short term outcomes. Currently, visceral transplant is the standard of care for patients with gut failure with life-threatening complications and complex abdominal pathology. Read More

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http://dx.doi.org/10.2174/1381612826666200707131857DOI Listing

Mathematical modelling can advance wound healing research.

Adv Wound Care (New Rochelle) 2020 Jul 7. Epub 2020 Jul 7.

The University of Melbourne - Parkville Campus, 2281, School of Mathematics and Statistics, Parkville, Melbourne, Victoria, Australia, 3010;

Significance: For over 30 years, there has been sustained interest in the development of mathematical models for investigating the complex mechanisms underlying each stage of the wound healing process. Despite the immense associated challenges, such models have helped usher in a paradigm shift in wound healing research. Recent Advances: In this paper, we review contributions in the field that span epidermal, dermal and corneal wound healing, and treatments of non-healing wounds. Read More

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http://dx.doi.org/10.1089/wound.2019.1132DOI Listing

Catalytic Nanoframes and Beyond.

Adv Mater 2020 Jul 7:e2001345. Epub 2020 Jul 7.

Department of Chemistry and Research Institute for Natural Sciences, Korea University, Seoul, 02841, Republic of Korea.

The ever-increasing need for the production and expenditure of sustainable energy is a result of the astonishing rate of consumption of fossil fuels and the accompanying environmental problems. Emphasis is being directed to the generation of sustainable energy by the fuel cell and water splitting technologies. Accordingly, the development of highly efficient electrocatalysts has attracted significant interest, as the fuel cell and water splitting technologies are critically dependent on their performance. Read More

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http://dx.doi.org/10.1002/adma.202001345DOI Listing

Synthesis of A-type Proanthocyanidins and their Analogues. A Comprehensive Review.

J Agric Food Chem 2020 Jul 7. Epub 2020 Jul 7.

Proanthocyanidins (PACs) are oligomers or polymers composed of units of flavanols. A-type proanthocyanidins are a subclass of PACs characterized by the presence of at least a double linkage between two consecutive monomers of flavanol. These A-type PACs are found in some fruits and spices and possess potential health benefits as a result of their interesting biological activities, and consequently their isolation and synthesis have given rise to great interest in the past. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c03380DOI Listing

Recent advances in nano-encapsulation of phytochemicals to combat obesity and its comorbidities.

J Agric Food Chem 2020 Jul 7. Epub 2020 Jul 7.

An increasing epidemic of obesity has become a serious public health concern primarily because it contributes to pathogenesis of many chronic diseases including type 2 diabetes, cardiovascular disease, hepatobiliary disease, obstructive sleep apnea, kidney disease, some types of cancer, among others. Consumption of a variety of phytochemicals has emerged as a promising potential for combating obesity and its comorbidities. However, the generally low aqueous solubility, stability, bioavailability, and target specificity of phytochemicals, along with their side-effects and toxicity seen when used at high doses, have restricted their clinical application. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c00131DOI Listing

Advances in Electrochemical Decarboxylative Transformation Reactions.

Chemistry 2020 Jul 7. Epub 2020 Jul 7.

Nanjing Tech University, Institute of Advanced Synthesis (IAS), NO.30 South Puzhu Road, 211816, Nanjing, CHINA.

Owing to their non-toxic, stable, inexpensive properties, carboxylic acids are considered as environmentally benign alternatives as coupling partners in various organic transformations. Electrochemical mediated decarboxylation of carboxylic acid has emerged as a new and efficient methodology for the construction of carbon-carbon or carbon-heteroatom bonds. Compared with transition-metal catalysis and photoredox catalysis, electro-organic decarboxylative transformations are considered as a green and sustainable protocol due to the absence of chemical oxidants and strong bases. Read More

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http://dx.doi.org/10.1002/chem.202001764DOI Listing

MHC class I transactivator NLRC5 in host immunity, cancer and beyond.

Immunology 2020 Jul 7. Epub 2020 Jul 7.

Department of Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules are crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family member, CIITA and NLRC5 functions as the major transcriptional activator of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class I related genes, there has been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Read More

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http://dx.doi.org/10.1111/imm.13235DOI Listing

[The volume of urological knowledge in the last 25 years.]

Arch Esp Urol 2020 Jul;73(6):487-490

Catedrático de Urología de la UAB. Jefe de Servicio de Urología y U.Q de Trasplante Renal (sin autoridad ejecutiva) Hospital del Mar. Barcelona. España.

Few specialties have gone through as many transitions in the last decades as Urology. Progressive physiology advances in several disease have become part of the urological knowledge. Laparoscopic surgery and ESWL (Extracorporeal Shock Wave Lithotripsy) wave have completely turn upside down the whole management of disease. Read More

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[Stroke Imaging].

Ther Umsch 2020 ;77(2):39-46

Klinik für Neuroradiologie, Universitätsspital Zürich.

Stroke Imaging In recent decades, imaging has become indispensable for the diagnosis and therapy of stroke. It provides information necessary to distinguish between hemorrhagic and ischemic stroke, to identify the cause of the symptoms and to determine the time of stroke. Increasingly, imaging is being used as a tool for making optimal therapeutic decisions. Read More

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http://dx.doi.org/10.1024/0040-5930/a001150DOI Listing
January 2020

[Imaging of the peripheral nervous system].

Ther Umsch 2020 ;77(2):63-68

Institut für Diagnostische und Interventionelle Radiologie, Universitätsspital Zürich.

Imaging of the peripheral nervous system With the technical advances in imaging achieved in recent years, the significance of radiology in everyday clinical practice has become definitely increased. This also applies to the diagnosis and evaluation of neuropathies. Highly sensitive electrophysiology is increasingly complemented by specific imaging. Read More

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http://dx.doi.org/10.1024/0040-5930/a001154DOI Listing
January 2020

[Magnetic resonance imaging of the liver - Diagnostic possibilities and new applications].

Ther Umsch 2020 ;77(2):69-74

Institut für Diagnostische und Interventionelle Radiologie, Universitätsspital Zürich.

Magnetic resonance imaging of the liver - Diagnostic possibilities and new applications Magnetic resonance imaging (MRI) of the liver plays an important role in the detection and characterization of focal and diffuse liver diseases and has many advantages over other imaging modalities. Liver MRI enables detection and diagnosis of most benign and malignant lesions. In addition to evaluating focal liver lesions, newer MR techniques for non-invasive accurate quantification of fat and iron in the liver have been established in recent years. Read More

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http://dx.doi.org/10.1024/0040-5930/a001155DOI Listing
January 2020

Recent advances in the development of asenapine formulations.

Expert Opin Drug Deliv 2020 Jul 7. Epub 2020 Jul 7.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education , Manipal, Karnataka, India 576104.

Introduction: Asenapine maleate (AM) is an atypical antipsychotic agent, that has been widely prescribed for the management of schizoaffective disorders. However, the bioavailability of AM is extremely poor due to the extensive first-pass metabolism. With the advancement in pharmaceutical technologies, significant strides have been made to create novel formulations to address the bioavailability problem of AM. Read More

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http://dx.doi.org/10.1080/17425247.2020.1792439DOI Listing

Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system.

J Zhejiang Univ Sci B 2020 Jul;21(7):509-523

Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

As the most prevalent and abundant transcriptional modification in the eukaryotic genome, the continuous and dynamic regulation of N6-methyladenosine (m6A) has been shown to play a vital role in physiological and pathological processes of cardiovascular diseases (CVDs), such as ischemic heart failure (HF), myocardial hypertrophy, myocardial infarction (MI), and cardiomyogenesis. Regulation is achieved by modulating the expression of m6A enzymes and their downstream cardiac genes. In addition, this process has a major impact on different aspects of internal biological metabolism and several other external environmental effects associated with the development of CVDs. Read More

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http://dx.doi.org/10.1631/jzus.B1900680DOI Listing

Bovine viral diarrhea virus: An updated American College of Veterinary Internal Medicine consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination.

J Vet Intern Med 2020 Jul 7. Epub 2020 Jul 7.

College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, USA.

Control of bovine viral diarrhea virus (BVDV) in cattle populations across most of the world has remained elusive in spite of advances in knowledge about this viral pathogen. A central feature of virus perseverance in cattle herds is the unique mechanism of persistent infection. Managing BVDV infection in herds involves controlling persistently infected carrier animals using a multidimensional approach of vaccination, biosecurity, and identification of BVDV reservoirs. Read More

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http://dx.doi.org/10.1111/jvim.15816DOI Listing

Smartdust 3D-Printed Graphene-Based Al/Ga Robots for Photocatalytic Degradation of Explosives.

Small 2020 Jul 7:e2002111. Epub 2020 Jul 7.

Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, Praha 6, Prague, 16822, Czech Republic.

Milli/micro/nanorobots are considered smart devices able to convert energy taken from different sources into mechanical movement and accomplish the appointed tasks. Future advances and realization of these tiny devices are mostly limited by the narrow window of material choices, the fuel requirement, multistep surface functionalization, rational structural design, and propulsion ability in complex environments. All these aspects call for intensive improvements that may speed up the real application of such miniaturized robots. Read More

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http://dx.doi.org/10.1002/smll.202002111DOI Listing

The role of population and quantitative genetics and modern sequencing technologies to understand evolved herbicide resistance and weed fitness.

Pest Manag Sci 2020 Jul 6. Epub 2020 Jul 6.

Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, 27695, USA.

Evolution of resistance to multiple herbicides with different sites of action and of nontarget site resistance (NTSR) often involves multiple genes. Thus, single-gene analyses, typical in studies of target site resistance, are not sufficient for understanding the genetic architecture and dynamics of NTSR and multiple-resistance. The genetics of weed adaptation to varied agricultural environments is also generally expected to be polygenic. Read More

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http://dx.doi.org/10.1002/ps.5988DOI Listing

Stereotactic radiotherapy for hepatocellular carcinoma: Expanding the multidisciplinary armamentarium.

J Gastroenterol Hepatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia.

Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third most common cause of cancer related death. Long-term prognosis remains poor with treatment options frequently limited by advanced tumor stage, tumor location, or underlying liver dysfunction. Stereotactic ablative body radiotherapy (SABR) utilises technological advances to deliver highly precise, tumoricidal doses of radiation. Read More

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http://dx.doi.org/10.1111/jgh.15175DOI Listing

Richard Allen Williams, M.D.: a Career Fighting Disparities and Fostering Equity.

J Racial Ethn Health Disparities 2020 Jul 6. Epub 2020 Jul 6.

Charles R. Drew University School of Medicine, Los Angeles, CA, USA.

This is a literature review where we acknowledge Richard Allen Williams, the first African American physician to win the John P. McGovern Compleat Physician Award, and recognize his achievements in race and ethnicity in healthcare. There have been significant advances in the diagnosis and treatment of cardiovascular disease; however, racial disparities continue to create inequity in the medical community especially for African Americans. Read More

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http://dx.doi.org/10.1007/s40615-020-00813-8DOI Listing

Correcting the Brain? The Convergence of Neuroscience, Neurotechnology, Psychiatry, and Artificial Intelligence.

Sci Eng Ethics 2020 Jul 6. Epub 2020 Jul 6.

St. Mary's University, Twickenham, UK.

The incorporation of neural-based technologies into psychiatry offers novel means to use neural data in patient assessment and clinical diagnosis. However, an over-optimistic technologisation of neuroscientifically-informed psychiatry risks the conflation of technological and psychological norms. Neurotechnologies promise fast, efficient, broad psychiatric insights not readily available through conventional observation of patients. Read More

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http://dx.doi.org/10.1007/s11948-020-00240-2DOI Listing

Strategies for living well with hormone-responsive advanced prostate cancer-a qualitative exploration.

Support Care Cancer 2020 Jul 6. Epub 2020 Jul 6.

Oxford School of Nursing and Midwifery, Oxford Brookes University, Oxford, OX3 0FL, UK.

Purpose: Due to recent treatment advances, men are increasingly living longer with advanced prostate cancer (PCa). This study sought to understand men's experiences of living with and adjusting to advanced hormone-responsive PCa and how this influenced their quality of life (QoL), in order to highlight how support could be optimized.

Methods: Participants were recruited through a UK wide survey-the 'Life After Prostate Cancer Diagnosis' study. Read More

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http://dx.doi.org/10.1007/s00520-020-05594-8DOI Listing

Comparative phosphoproteomic analysis of BR-defective mutant reveals a key role of GhSK13 in regulating cotton fiber development.

Sci China Life Sci 2020 Jul 3. Epub 2020 Jul 3.

Zhengzhou Research Base, State Key Laboratory of Cotton Biology, Zhengzhou University, Zhengzhou, 450001, China.

Brassinosteroid (BR), a steroid phytohormone, whose signaling transduction pathways include a series of phosphorylation and dephosphorylation events, and GSK3s are the main negative regulator kinases. BRs have been shown to play vital roles in cotton fiber elongation. However, the underlying mechanism is still elusive. Read More

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http://dx.doi.org/10.1007/s11427-020-1728-9DOI Listing

Recent advances in tau-directed immunotherapy against Alzheimer's disease: an overview of pre-clinical and clinical development.

Metab Brain Dis 2020 Jul 6. Epub 2020 Jul 6.

School of Health Science, Division of Biomedical Science and Biotechnology, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.

Alzheimer's disease (AD) has been a worldwide concern for many years now. This is due to the fact that AD is an irreversible and progressive neurodegenerative disease that affects quality of life. Failure of some Phase II/III clinical trials in AD targeting accumulation of β-amyloid in the brain has led to an increase in interest in studying alternative treatments against tubulin-associated unit (Tau) pathology. Read More

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http://dx.doi.org/10.1007/s11011-020-00591-6DOI Listing

Tumor dormancy in bone.

Cancer Rep (Hoboken) 2020 Feb 29;3(1). Epub 2019 Jan 29.

Vanderbilt Center for Bone Biology.

Background: Bone marrow is a common site of metastasis for a number of tumor types, including breast, prostate, and lung cancer, but the mechanisms controlling tumor dormancy in bone are poorly understood. In breast cancer, while advances in drug development, screening practices, and surgical techniques have dramatically improved survival rates in recent decades, metastatic recurrence in the bone remains common and can develop years or decades after elimination of the primary tumor.

Recent Findings: It is now understood that tumor cells disseminate to distant metastatic sites at early stages of tumor progression, leaving cancer survivors at a high risk of recurrence. Read More

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http://dx.doi.org/10.1002/cnr2.1156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337256PMC
February 2020

Associated liver partition and portal vein ligation for staged hepatectomy: a review.

Transl Gastroenterol Hepatol 2020 5;5:37. Epub 2020 Jul 5.

Department of General Surgery, Tan Tock Seng Hospital, Singapore.

Outcomes of liver resection have improved with advances in surgical techniques, improvements in critical care and expansion of resectability criteria. However, morbidity and mortality following liver resection continue to plague surgeons. Post-hepatectomy liver failure (PHLF) due to inadequate future liver remnant (FLR) is an important cause of morbidity and mortality following liver resection. Read More

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http://dx.doi.org/10.21037/tgh.2019.12.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063517PMC

Applying technological advances in behavioral researches.

Authors:
Erik Andersson

Mhealth 2020 5;6:25. Epub 2020 Jul 5.

Division of Psychology, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. (Email:

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http://dx.doi.org/10.21037/mhealth.2020.03.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327287PMC

Quality of Life After Radiotherapy for Rectal and Anal Cancer.

Curr Colorectal Cancer Rep 2020 Feb 16;16(1):1-10. Epub 2020 Jan 16.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States.

Purpose Of Review: With advances in radiation therapy (RT) techniques for rectal and anal cancers allowing for the modulation of critical normal tissues, there has been an increased emphasis on improving the quality of life (QOL) of cancer survivors. Herein, we review the literature to examine the impact of RT on QOL and patient reported outcomes (PROs) to better inform providers about the challenges of survivorship.

Recent Findings: Large systematic reviews, recent studies and long-term follow-up of pivotal clinical trials have shown that RT impacts QOL, particularly fecal continence and sexual function. Read More

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http://dx.doi.org/10.1007/s11888-019-00448-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336840PMC
February 2020

T cell antigen discovery.

Nat Methods 2020 Jul 6. Epub 2020 Jul 6.

Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that recognize short peptide antigens presented on major histocompatibility complex (MHC) proteins. The TCR-peptide-MHC interaction mediated between a T cell and its target cell dictates its function and thereby influences its role in disease. A lack of approaches for antigen discovery has limited the fundamental understanding of the antigenic landscape of the overall T cell response. Read More

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http://dx.doi.org/10.1038/s41592-020-0867-zDOI Listing

Publisher Correction: 'TRAIL-based gene delivery and therapeutic strategies' and 'Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy'.

Acta Pharmacol Sin 2020 Jul 6. Epub 2020 Jul 6.

State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41401-020-0444-0DOI Listing

Active photonic wireless power transfer into live tissues.

Proc Natl Acad Sci U S A 2020 Jul 6. Epub 2020 Jul 6.

School of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), 61005 Gwangju, Republic of Korea;

Recent advances in soft materials and mechanics activate development of many new types of electrical medical implants. Electronic implants that provide exceptional functions, however, usually require more electrical power, resulting in shorter period of usages although many approaches have been suggested to harvest electrical power in human bodies by resolving the issues related to power density, biocompatibility, tissue damage, and others. Here, we report an active photonic power transfer approach at the level of a full system to secure sustainable electrical power in human bodies. Read More

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http://dx.doi.org/10.1073/pnas.2002201117DOI Listing

ARTP statement on pulmonary function testing 2020.

BMJ Open Respir Res 2020 Jul;7(1)

Department of Respiratory Medicine, Dorset County Hospital NHS Foundation Trust, Dorchester, Dorset, UK.

The Association for Respiratory Technology & Physiology (ARTP) last produced a statement on the performance of lung function testing in 1994. At that time the focus was on a practical statement for people working in lung function laboratories. Since that time there have been many technological advances and alterations to best practice in the measurement and interpretation of lung function assessments. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000575DOI Listing

Pandemic advances alternatives to hallway medicine.

Authors:
Catherine Varner

CMAJ 2020 Jul;192(27):E789-E790

Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.1095880DOI Listing

Sharing vitamins: Cobamides unveil microbial interactions.

Science 2020 Jul;369(6499)

Department of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.

Microbial communities are essential to fundamental processes on Earth. Underlying the compositions and functions of these communities are nutritional interdependencies among individual species. One class of nutrients, cobamides (the family of enzyme cofactors that includes vitamin B), is widely used for a variety of microbial metabolic functions, but these structurally diverse cofactors are synthesized by only a subset of bacteria and archaea. Read More

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http://dx.doi.org/10.1126/science.aba0165DOI Listing

RIPK2 NODs to XIAP and IBD.

Semin Cell Dev Biol 2020 Jul 3. Epub 2020 Jul 3.

Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK. Electronic address:

The receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders. RIPK2 mediates signalling responses initiated by the bacterial-sensing pattern recognition receptors nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2), which play a key role in regulation of intestinal immunity and inflammation. Modification of RIPK2 by non-degradative ubiquitin chains generated by the E3 ubiquitin ligase XIAP and other ligases govern NOD1/2 signalling. Read More

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http://dx.doi.org/10.1016/j.semcdb.2020.07.001DOI Listing

Microbial communities from arid environments on a global scale. A systematic review.

Biol Res 2020 Jul 6;53(1):29. Epub 2020 Jul 6.

Laboratorio de Bioinformática y Expresión Génica, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile.

Arid environments are defined by the lack of water availability, which is directly related to the mean annual precipitation (MAP), and high values of solar irradiation, which impacts the community composition of animals, plants, and the microbial structure of the soil. Recent advances in NGS technologies have expanded our ability to characterize microbiomes, allowing environmental microbiologists to explore the complete microbial structure. Intending to identify and describe the state-of-the-art of bacterial communities in arid soils at a global scale, and to address the effect that some environmental features may have on them, we performed a systematic review based on the PRISMA guideline. Read More

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http://dx.doi.org/10.1186/s40659-020-00296-1DOI Listing

Hepatitis C virus vaccine design: focus on the humoral immune response.

J Biomed Sci 2020 Jul 6;27(1):78. Epub 2020 Jul 6.

Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Carretera Majadahonda-Pozuelo, Km 2.2;Majadahonda, 28220, Madrid, Spain.

Despite the recent development of safe and highly effective direct-acting antivirals, hepatitis C virus (HCV) infection remains a significant health problem. In 2016, the World Health Organization set out to reduce the rate of new HCV infections by 90% by 2030. Still, global control of the virus does not seem to be achievable in the absence of an effective vaccine. Read More

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http://dx.doi.org/10.1186/s12929-020-00669-4DOI Listing