229,723 results match your criteria Advances In Concrete Construction[Journal]


A scalable database of organ doses for common diagnostic fluoroscopy examinations of children: procedures of current practice at the University of Florida.

Phys Med Biol 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Engineering, University of Florida, PO Box 116131, 1275 Center Drive, Gainesville, Florida, 32611-6131, UNITED STATES.

Of all the medical imaging modalities that utilize ionizing radiation, fluoroscopy proves to be the most difficult to assess values of patient organ dose owing to the dynamic and patient-specific nature of the irradiation geometry and its associated x-ray beam characteristics. With the introduction of the radiation dose structured report (RDSR) in the mid-2000s, however, computational tools have been developed to extract patient and procedure-specific data for each irradiation event of the study, and when coupled to a computational phantom of the patient, values of skin and internal organ dose may be assessed. Unfortunately, many legacy and even current diagnostic fluoroscopy units do not have RDSR reporting capabilities, thus limiting these dosimetry reporting advances. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1badDOI Listing

Direct-write crosslinking in vacuum-deposited small-molecule films using focussed ion and electron beams.

Nanotechnology 2019 Apr 23. Epub 2019 Apr 23.

School of Chemistry Physics and Mechanical Engineering and Institute for Future Environments, Queensland University of Technology Faculty of Science and Engineering, Brisbane, Queensland, AUSTRALIA.

Recent advances in helium ion microscopy (HIM) have enabled the use of fine-focused He+ beams to image and shape materials at the nanoscale. In addition to traditional ion milling, the beam can also be used to induce reactions, such as cross-linking, in films of organic molecules. Here, we compare the use of focused ion and electron beams to fabricate spatially-defined cross-linked features in nanometre-thick films of tetracene. Read More

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http://dx.doi.org/10.1088/1361-6528/ab1b86DOI Listing

Multifunctional Organic Emitters for High-performance and Low-cost Organic Light-emitting Didoes.

Chem Rec 2019 Apr 23. Epub 2019 Apr 23.

Microelectronic R&D Center, School of Mechatronic Engineering and Automation, Shanghai University, 149 Yanchang Road, Shanghai, 200072, P. R. China.

Organic light-emitting diodes (OLEDs) have great potential applications in display and solid-state lighting. Stability, cost and high operational efficiency are key issues governing the future commercial application of OLEDs. In this context, searching for multifunctional emitting materials with acceptable light-emitting and charge-transporting characteristics has gained increasing attention. Read More

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http://dx.doi.org/10.1002/tcr.201900005DOI Listing

Advances in lead-free double perovskite nanocrystals, engineering band-gaps and enhancing stability through composition tunability.

Nanoscale 2019 Apr 23. Epub 2019 Apr 23.

Department of Materials Science and Engineering, Technion - Israel Institute of Technology, 32000 Haifa, Israel. and The Solid-State Institute, Technion - Israel Institute of Technology, 32000 Haifa, Israel.

In this topical review, we have focused on the recent advances made in the studies of lead-free perovskites in the bulk form and as nanocrystals. Substitution of lead in halide perovskites is essential to overcome the toxicity concerns and improve the relatively low stability of these materials. In lead-free double perovskites the unit cell is doubled and two divalent lead cations are replaced by mono and trivalent cations. Read More

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http://dx.doi.org/10.1039/c9nr01031aDOI Listing

Implementing continuous non-normal skewed distributions in latent growth mixture modeling: An assessment of specification errors and class enumeration.

Multivariate Behav Res 2019 Apr 23:1-27. Epub 2019 Apr 23.

b Pontificia Universidad Católica Madre y Maestra , Santiago , Dominican Republic.

Recent advances have allowed for modeling mixture components within latent growth modeling using robust, skewed mixture distributions rather than normal distributions. This feature adds flexibility in handling non-normality in longitudinal data, through manifest or latent variables, by directly modeling skewed or heavy-tailed latent classes rather than assuming a mixture of normal distributions. The aim of this study was to assess through simulation the potential under- or over-extraction of latent classes in a growth mixture model when underlying data follow either normal, skewed-normal, or skewed-t distributions. Read More

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http://dx.doi.org/10.1080/00273171.2019.1593813DOI Listing

Laser Acceleration of Highly Energetic Carbon Ions Using a Double-Layer Target Composed of Slightly Underdense Plasma and Ultrathin Foil.

Phys Rev Lett 2019 Jan;122(1):014803

Center for Relativistic Laser Science, Institute for Basic Science, Gwangju 61005, Korea.

We report the experimental generation of highly energetic carbon ions up to 48 MeV per nucleon by shooting double-layer targets composed of well-controlled slightly underdense plasma and ultrathin foils with ultraintense femtosecond laser pulses. Particle-in-cell simulations reveal that carbon ions are ejected from the ultrathin foils due to radiation pressure and then accelerated in an enhanced sheath field established by the superponderomotive electron flow. Such a cascaded acceleration is especially suited for heavy ion acceleration with femtosecond laser pulses. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.014803DOI Listing
January 2019

Phonon Spectroscopy at Atomic Resolution.

Phys Rev Lett 2019 Jan;122(1):016103

School of Physics, University of Melbourne, Parkville, Victoria 3010, Australia.

Advances in source monochromation in transmission electron microscopy have opened up new possibilities for investigations of condensed matter using the phonon-loss sector of the energy-loss spectrum. Here, we explore the spatial variations of the spectrum as an atomic-sized probe is scanned across a thin flake of hexagonal boron nitride. We demonstrate that phonon spectral mapping of atomic structure is possible. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.016103DOI Listing
January 2019

Adhesive supramolecular polymeric materials constructed from macrocycle-based host-guest interactions.

Chem Soc Rev 2019 Apr 23. Epub 2019 Apr 23.

Department of Chemistry, The University of Texas at Austin, 105 East 24th Street, Stop A5300, Austin, Texas 78712, USA. and Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai, 200444, P. R. China.

Nature uses the power of non-covalent interactions as the basis for many kinds of adhesion phenomena. Inspired by nature, scientists have prepared various synthetic adhesive materials that rely on a number of non-covalent interactions at the interfaces. Commonly used non-covalent interactions include hydrogen bonding, π-π stacking, charge transfer interactions, electrostatic interactions, hydrophobic interactions, macrocycle-based host-guest interactions, among others. Read More

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http://dx.doi.org/10.1039/c8cs00955dDOI Listing

Integration of genomic and clinical data augments surveillance of healthcare-acquired infections.

Infect Control Hosp Epidemiol 2019 Apr 23:1-7. Epub 2019 Apr 23.

Department of Microbiology and Physiological Systems,University of Massachusetts Medical School,Worcester,Massachusetts.

Background: Determining infectious cross-transmission events in healthcare settings involves manual surveillance of case clusters by infection control personnel, followed by strain typing of clinical/environmental isolates suspected in said clusters. Recent advances in genomic sequencing and cloud computing now allow for the rapid molecular typing of infecting isolates.

Objective: To facilitate rapid recognition of transmission clusters, we aimed to assess infection control surveillance using whole-genome sequencing (WGS) of microbial pathogens to identify cross-transmission events for epidemiologic review. Read More

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http://dx.doi.org/10.1017/ice.2019.75DOI Listing

From disability to human flourishing: how fourth wave psychotherapies can help to reimagine rehabilitation and medicine as a whole.

Disabil Rehabil 2019 Apr 23:1-7. Epub 2019 Apr 23.

c Department of Psychiatry, Brigham And Women's Hospital , Harvard Medical School , Boston , MA , USA.

Aim: With disabled patients, clinicians are often mechanistically oriented, limiting goals to bodily improvements of perceived deficits back to species-typical functioning. Psychological goals, when present at all, are often pessimistically narrow, or phenomenologically shallow. Recent research on fourth wave psychotherapies helps broaden clinical concepts of healing and treatment beyond mere deficit remediation, and helps match clinical goals with the richness of human flourishing and the layered complexity of the patient's evolving experience of meaning. Read More

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http://dx.doi.org/10.1080/09638288.2019.1602674DOI Listing

Recent Advances on Electrochemical Sensors for the Detection of Organic Disinfection Byproducts in Water.

ACS Sens 2019 Apr 23. Epub 2019 Apr 23.

College of Engineering , Swansea University , Bay Campus, Swansea SA1 8EN , United Kingdom.

Irreversible organ damage or even death frequently occurs when humans or animals unknowingly drink contaminated water. Therefore, in many countries drinking water is disinfected to ensure removal of harmful pathogens from drinking water. If upstream water treatment prior to disinfection is not adequate, disinfection byproducts (DBPs) can be formed. Read More

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http://dx.doi.org/10.1021/acssensors.9b00272DOI Listing

3D Bioprinting in Skeletal Muscle Tissue Engineering.

Small 2019 Apr 23:e1805530. Epub 2019 Apr 23.

Center for Minimally Invasive Therapeutics (C-MIT), Department of Radiological Sciences, University of California, Los Angeles, CA, 90095, USA.

Skeletal muscle tissue engineering (SMTE) aims at repairing defective skeletal muscles. Until now, numerous developments are made in SMTE; however, it is still challenging to recapitulate the complexity of muscles with current methods of fabrication. Here, after a brief description of the anatomy of skeletal muscle and a short state-of-the-art on developments made in SMTE with "conventional methods," the use of 3D bioprinting as a new tool for SMTE is in focus. Read More

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http://dx.doi.org/10.1002/smll.201805530DOI Listing

Quantum Sensing in a Physiological-Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers.

Small 2019 Apr 22:e1900455. Epub 2019 Apr 22.

Optics and Photonics Research Group, Faculty of Engineering, University Park, Nottingham, NG7 2RD, UK.

Fluorescent nanodiamonds (fNDs) containing nitrogen vacancy (NV) centers are promising candidates for quantum sensing in biological environments. This work describes the fabrication and implementation of electrospun poly lactic-co-glycolic acid (PLGA) nanofibers embedded with fNDs for optical quantum sensing in an environment, which recapitulates the nanoscale architecture and topography of the cell niche. A protocol that produces uniformly dispersed fNDs within electrospun nanofibers is demonstrated and the resulting fibers are characterized using fluorescent microscopy and scanning electron microscopy (SEM). Read More

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http://dx.doi.org/10.1002/smll.201900455DOI Listing

Failure to place evidence at the centre of quality improvement remains a major barrier for advances in quality improvement.

J Eval Clin Pract 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Mondoux and Shojania (M&S) issued a critique of our call to unify all disciplines of relevance for quality improvement (QI). They do not challenge the need for alignment of different fields that have played roles in the QI space. They selected to focus their critique on our views that ultimately the discipline of QI should be based on the principles of evidence-based medicine (EBM) and decision sciences. Read More

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http://dx.doi.org/10.1111/jep.13146DOI Listing

Cancer immunotherapy: advances and future challenges.

Immunol Cell Biol 2019 Apr;97(4):353-354

Department of Biochemistry and Molecular Biology, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1111/imcb.12250DOI Listing

Characterizing Proteins in their Cellular Environment: Examples of recent advances in quantitative fluorescence microscopy.

Protein Sci 2019 Apr 23. Epub 2019 Apr 23.

Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180.

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http://dx.doi.org/10.1002/pro.3630DOI Listing

Biotechnological application of endophytic filamentous bipolaris and curvularia: a review on bioeconomy impact.

World J Microbiol Biotechnol 2019 Apr 22;35(5):69. Epub 2019 Apr 22.

Institute of Child Health, Kolkata, West Bengal, 700017, India.

The filamentous Bipolaris and Curvularia genera consist of species known to cause severe diseases in plants and animals amounting to an estimated annual loss of USD $10 billion worldwide. Despite the harmful effect of Bipolaris and Curvularia species, scarce attention is paid on beneficial areas where the fungi are used in industrial processes to generate biotechnological products. Catalytic potential of Bipolaris and Curvularia species in the production of biodiesel, bioflucculant, biosorbent, and mycoherbicide are promising for the bioeconomy. Read More

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http://dx.doi.org/10.1007/s11274-019-2644-7DOI Listing

Recent advances in the biocontrol of Xanthomonas spp.

World J Microbiol Biotechnol 2019 Apr 22;35(5):72. Epub 2019 Apr 22.

Department of Biochemistry and Microbiology, Institute of Biosciences, São Paulo State University (UNESP) "Júlio de Mesquita Filho", Rio Claro, São Paulo, Brazil.

Bacterial diseases caused by members of the genus Xanthomonas affect agricultural crops of great importance in the world. At least 350 different plant diseases are caused by species of Xanthomonas. Important crops, such as: rice, citrus, cassava, tomato, sugar cane, passionfruit and brassicas are severely affected by bacteria of this genus. Read More

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http://dx.doi.org/10.1007/s11274-019-2646-5DOI Listing

Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes.

Curr Cardiol Rep 2019 Apr 22;21(6):45. Epub 2019 Apr 22.

Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, 5001 El Paso Drive, MSC 21009, El Paso, TX, 79905, USA.

Purpose Of Review: The aims of this review are to summarize recent data on mortality and cardiovascular disease (CVD) in type 1 and type 2 diabetes and to determine the interventions that could have contributed to a reduction in mortality.

Recent Findings: Recent studies found a downward trend in mortality and CVD among both diabetics and non-diabetics worldwide over the last few decades. The decline among diabetics is steeper than that among non-diabetics. Read More

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http://link.springer.com/10.1007/s11886-019-1133-9
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http://dx.doi.org/10.1007/s11886-019-1133-9DOI Listing
April 2019
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Impact framework: A python package for writing data analysis workflows to interpret microbial physiology.

Metab Eng Commun 2019 Dec 4;9:e00089. Epub 2019 Apr 4.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.

Microorganisms can be genetically engineered to solve a range of challenges in diverse including health, environmental protection and sustainability. The natural complexity of biological systems makes this an iterative cycle, perturbing metabolism and making stepwise progress toward a desired phenotype through four major stages: design, build, test, and data interpretation. This cycle has been accelerated by advances in molecular biology (e. Read More

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http://dx.doi.org/10.1016/j.mec.2019.e00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462781PMC
December 2019

Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept.

Aging Dis 2019 Apr 1;10(2):367-382. Epub 2019 Apr 1.

8Department of Physiology, The University of Texas Health Science Center at San Antonio, TX 78229, USA.

Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. Currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. However, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0324
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http://dx.doi.org/10.14336/AD.2018.0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457053PMC

Management of Hodgkin Lymphoma in a Sickle Cell Patient: A Case Report.

Case Rep Oncol 2019 Jan-Apr;12(1):224-227. Epub 2019 Mar 5.

New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.

Sickle cell disease (SCD) is an inherited disorder of hemoglobin mutation in red blood cells, with a patient population that is increasing in age in recent decades due to advances in modern medicine. Hodgkin's lymphoma (HL) is a cancer of white blood cells, and while concomitance of SCD and Hodgkin's has been reported, a discussion of treatment for HL in SCD is lacking from the literature. We present a case of effectively treated HL in SCD and put forth that the regimen used is a practical choice, and as it was completed fully as outpatient, it improved the patient's quality of life compared to an inpatient regimen. Read More

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http://dx.doi.org/10.1159/000497480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465740PMC

Integration of a Personalized Molecular Targeted Therapy into the Multimodal Treatment of Refractory Childhood Embryonal Tumor with Multilayered Rosettes (ETMR).

Case Rep Oncol 2019 Jan-Apr;12(1):211-217. Epub 2019 Feb 28.

Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.

Embryonal tumor with multilayered rosettes (ETMR) are rare pediatric brain tumors with increased malignant potential. Despite the advances in multimodal treatment schemes the overall 5-year event free survival rates for ETMR are not favorable. Further, therapeutic regimes are limited to a case by case basis due to the limited amount of literature and guidelines available for treating childhood ETMR. Read More

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http://dx.doi.org/10.1159/000497380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465683PMC
February 2019

Update on hepatocellular carcinoma: Pathologists' review.

World J Gastroenterol 2019 Apr;25(14):1653-1665

Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208, United States.

Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma (HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Read More

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http://dx.doi.org/10.3748/wjg.v25.i14.1653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465943PMC

Programming CAR-T cells to kill cancer.

Nat Biomed Eng 2018 Jun 11;2(6):377-391. Epub 2018 Jun 11.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

T cells engineered to express chimeric antigen receptors (CARs) that are specific for tumour antigens have led to high complete response rates in patients with haematologic malignancies. Despite this early success, major challenges to the broad application of CAR-T cells as cancer therapies remain, including treatment-associated toxicities and cancer relapse with antigen-negative tumours. Targeting solid tumours with CAR-T cells poses additional obstacles because of the paucity of tumour-specific antigens and the immunosuppressive effects of the tumour microenvironment. Read More

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http://www.nature.com/articles/s41551-018-0235-9
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http://dx.doi.org/10.1038/s41551-018-0235-9DOI Listing
June 2018
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Harnessing cell pluripotency for cardiovascular regenerative medicine.

Nat Biomed Eng 2018 Jun 11;2(6):392-398. Epub 2018 Jun 11.

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.

Human pluripotent stem cells (hPSCs), in particular embryonic stem cells and induced pluripotent stem cells, have received enormous attention in cardiovascular regenerative medicine owing to their ability to expand and differentiate into functional cardiomyocytes and other cardiovascular cell types. Despite the potential applications of hPSCs for tissue regeneration in patients suffering from cardiovascular disease, whether hPSC-based therapies can be safe and efficacious remains inconclusive, with strong evidence from clinical trials lacking. Critical factors limiting therapeutic efficacy are the degree of maturity and purity of the hPSC-derived differentiated progeny, and the tumorigenic risk associated with residual undifferentiated cells. Read More

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http://dx.doi.org/10.1038/s41551-018-0244-8DOI Listing

Impact and mitigation of angular uncertainties in Bragg coherent x-ray diffraction imaging.

Sci Rep 2019 Apr 23;9(1):6386. Epub 2019 Apr 23.

Materials Science Division, Argonne National Laboratory, Argonne, Illinois, 60439, USA.

Bragg coherent diffraction imaging (BCDI) is a powerful technique to explore the local strain state and morphology of microscale crystals. The method can potentially reach nanometer-scale spatial resolution thanks to the advances in synchrotron design that dramatically increase coherent flux. However, there are experimental bottlenecks that may limit the image reconstruction quality from future high signal-to-noise ratio measurements. Read More

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http://www.nature.com/articles/s41598-019-42797-4
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http://dx.doi.org/10.1038/s41598-019-42797-4DOI Listing
April 2019
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Naturalistic Driving: A Framework and Advances in Using Big Data.

Geriatrics (Basel) 2018 Mar 29;3(2). Epub 2018 Mar 29.

Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada.

Driving is an activity that facilitates physical, cognitive, and social stimulation in older adults, ultimately leading to better physical and cognitive health. However, aging is associated with declines in vision, physical health, and cognitive health, all of which can affect driving ability. One way of assessing driving ability is with the use of sensors in the older adult's own vehicle. Read More

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http://www.mdpi.com/2308-3417/3/2/16
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http://dx.doi.org/10.3390/geriatrics3020016DOI Listing
March 2018
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Challenges for Older Drivers in Urban, Suburban, and Rural Settings.

Geriatrics (Basel) 2018 Mar 22;3(2). Epub 2018 Mar 22.

Department of Industrial and Systems Engineering, College of Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

Along with age-related factors, geographical settings-urban, suburban, and rural areas-also contribute to the differences in fatal crashes among older drivers. These differences in crash outcomes might be attributed to the various driving challenges faced by older drivers residing in different locations. To understand these challenges from the perspective of the older driver, a focus group study was conducted with drivers 65 and older from urban, suburban, and rural settings. Read More

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http://dx.doi.org/10.3390/geriatrics3020014DOI Listing

Fitting pieces into the puzzle of type III secretion system gene expression.

J Bacteriol 2019 Apr 22. Epub 2019 Apr 22.

Department of Microbiology and Immunology, University of Iowa

Type III secretion systems (T3SS) are widely distributed in Gram-negative microorganisms and critical for host-pathogen and host-symbiont interactions with plants and animals. Central features of the T3SS are a highly conserved set of secretion and translocation genes and contact-dependence wherein host-pathogen interactions trigger effector protein delivery and serve as an inducing signal for T3SS gene expression. In addition to these conserved features there are also pathogen-specific properties that include a unique repertoire of effector genes and mechanisms to control T3SS gene expression. Read More

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http://dx.doi.org/10.1128/JB.00209-19DOI Listing

Monoclonal gammopathy of undetermined significance (MGUS).

Blood 2019 Apr 22. Epub 2019 Apr 22.

Medical Oncology/Hematologic Malignancies, Dana-Farber Cancer Institute, United States

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell dyscrasia that consistently precedes multiple myeloma (MM) with a 1% risk of progression per year. Recent advances have improved understanding of the complex genetic and immunologic factors that drive and permit progression from aberrant plasma cell clone to MGUS and overt MM. Additional evidence supports a bidirectional interaction of MGUS cells with surrounding cells in the bone marrow niche that regulates malignant transformation. Read More

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http://dx.doi.org/10.1182/blood.2019846782DOI Listing

Oral Drug Delivery Technologies-A Decade of Developments.

J Pharmacol Exp Ther 2019 Apr 22. Epub 2019 Apr 22.

Texas A&M University

Advanced drug delivery technologies in general can enable drug reformulation and administration routes, together contributing to life-cycle management allowing the innovator to maintain the product monopoly. Over the years there has been a steady shift from mere life-cycle management to drug re-purposing, or applying delivery technologies to tackle solubility and permeability issues in early stage or safety and efficacy issues in the late stage drug discovery processes. While the drug and the disease in question primarily drives the choice of route of administration, oral route for its compliance and safety attributes is the most preferred route, particularly when it comes to chronic conditions including pain that is not considered a disease, but a symptom of a primary cause. Read More

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http://dx.doi.org/10.1124/jpet.118.255828DOI Listing

[New insights in the pathogenesis of pulmonary arterial hypertension].

Rev Mal Respir 2019 Apr 19. Epub 2019 Apr 19.

Inserm UMR_S 999, hôpital Marie Lannelongue, 133, avenue de la Résistance, 92350 Le Plessis-Robinson, France; Faculté de Médecine, université Paris-Sud, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France. Electronic address:

Pulmonary arterial hypertension (PAH) is a severe and incurable cardiopulmonary disorder. Research from the past 10 years illustrates the complex and multifactorial aspects of PAH pathophysiology. Furthermore, latest advances in the field have led to a better understanding of the key components underlying this inadequate accumulation of pulmonary vascular cells within the pulmonary arterial walls, leading to pulmonary vascular remodelling. Read More

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http://dx.doi.org/10.1016/j.rmr.2019.03.003DOI Listing

Contact tracing for hepatitis C: The case for novel screening strategies as we strive for viral elimination.

Int J Drug Policy 2019 Apr 19. Epub 2019 Apr 19.

NYU School of Medicine, United States.

Contact tracing has been a key element of the public health response to infectious diseases for decades. These practices have been powerful in slowing the spread of tuberculosis, HIV, and other sexually transmitted infections. Despite success in other contexts, contact tracing for hepatitis C virus (HCV) has historically been considered infeasible because of a long asymptomatic period, which often makes it difficult to pinpoint the time of acquisition. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.04.003DOI Listing

Recent updates on alcoholic hepatitis.

Dig Liver Dis 2019 Apr 19. Epub 2019 Apr 19.

Division of Gastroenterology and Hepatology, University of South Dakota, Avera McKennan University Health Center and Transplant Institute, Sioux Falls, SD 57105, United States. Electronic address:

Alcoholic hepatitis (AH) is a unique clinical syndrome that affects patients with chronic and active harmful alcohol consumption, and is associated with a high mortality of up to 40% at 1 month from presentation. It is important to assess disease severity and prognosis at time of presentation to identify patients at risk for high mortality and potential candidates for specific therapies. The cornerstone therapy for AH is enteral nutrition and abstinence. Read More

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http://dx.doi.org/10.1016/j.dld.2019.03.023DOI Listing

A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer.

Biochem Biophys Res Commun 2019 Apr 19. Epub 2019 Apr 19.

National Translational Science Center for Molecular Medicine, Air Force Medical University, Xi'an, 710032, China; Department of Cell Biology, School of Basic Medicine, Air Force Medical University, Xi'an, 710032, China. Electronic address:

Cluster of differentiation 147 (CD147), a transmembrane protein of the immunoglobulin superfamily, is a potential target of treatment against human non-small cell lung cancer (NSCLC). Although there have been exciting advances in epidermal growth factor receptor (EGFR)-targeted therapy for NSCLC in recent years, additional novel targeted agents are needed to improve the efficiency and to offer more options for patients. Antibody-drug conjugates (ADCs) utilize a chemical linker to conjugate cytotoxic drugs to a monoclonal antibody to maximize the delivery to target cells and minimize the delivery to other normal cells. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.046DOI Listing

Hot topics in opioid pharmacology: mixed and biased opioids.

Br J Anaesth 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiovascular Sciences, University of Leicester, Anaesthesia, Critical Care and Pain Management, Leicester Royal Infirmary, Leicester, UK. Electronic address:

Analgesic design and evaluation have been driven by the desire to create high-affinity high-selectivity mu (μ)-opioid peptide (MOP) receptor agonists. Such ligands are the mainstay of current clinical practice, and include morphine and fentanyl. Advances in this sphere have come from designing pharmacokinetic advantage, as in rapid metabolism for remifentanil. Read More

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http://dx.doi.org/10.1016/j.bja.2019.03.006DOI Listing

Elevated serum concentrations of DNAJB9 in fibrillary glomerulonephritis: another step toward understanding a progressive disease.

Authors:
Nicole K Andeen

Kidney Int 2019 May;95(5):1025-1026

Department of Pathology, Oregon Health & Science University, Portland, Oregon, USA. Electronic address:

DnaJ homolog subfamily B member 9 (DNAJB9) is a sensitive and specific marker of fibrillary glomerulonephritis (FGN) in kidney biopsies. In this issue, Nasr and Dasari et al. demonstrate significantly elevated concentrations of DNAJB9 in serum from patients with FGN. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.034DOI Listing

Current and Future Idiopathic Pulmonary Fibrosis Therapy.

Am J Med Sci 2019 May 11;357(5):370-373. Epub 2019 Feb 11.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

The last years have led to advances in the therapeutic management of idiopathic pulmonary fibrosis (IPF), mainly through the discovery of new pathological pathways and drugs and better design of clinical trials. The objective of this review is both to describe the current therapies approved for the treatment of IPF and the emerging therapeutic approaches. Currently, nintedanib and pirfenidone are the basis of IPF therapy, based on the results of large randomized clinical trials showing their safety and efficacy in reducing disease progression. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.006DOI Listing

Future Prospects in the Treatment of Parasitic Diseases: 2-Amino-1,3,4-Thiadiazoles in Leishmaniasis.

Authors:
Georgeta Serban

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga, 410028 Oradea, Romania.

Neglected tropical diseases affect the lives of a billion people worldwide. Among them, the parasitic infections caused by protozoan parasites of the family have a huge impact on human health. Leishmaniasis, caused by spp. Read More

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http://dx.doi.org/10.3390/molecules24081557DOI Listing

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment.

Nanomaterials (Basel) 2019 Apr 19;9(4). Epub 2019 Apr 19.

Department of Organic Chemistry, Faculty of Sciences. University of Málaga, 29071 Málaga, Spain.

Many therapeutically active molecules are non-soluble in aqueous systems, chemically and biologically fragile or present severe side effects. Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. Read More

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http://dx.doi.org/10.3390/nano9040638DOI Listing

Advances on Photonic Crystal Fiber Sensors and Applications.

Sensors (Basel) 2019 Apr 21;19(8). Epub 2019 Apr 21.

Dipartimento di Ingegneria Elettrica e dell'Informazione, Politecnico di Bari, Via E. Orabona 4, 70125 Bari, Italy.

In this review paper some recent advances on optical sensors based on photonic crystal fibres are reported. The different strategies successfully applied in order to obtain feasible and reliable monitoring systems in several application fields, including medicine, biology, environment sustainability, communications systems are highlighted. Emphasis is given to the exploitation of integrated systems and/or single elements based on photonic crystal fibers employing Bragg gratings (FBGs), long period gratings (LPGs), interferometers, plasmon propagation, off-set spliced fibers, evanescent field and hollow core geometries. Read More

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http://dx.doi.org/10.3390/s19081892DOI Listing

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Viruses 2019 Apr 20;11(4). Epub 2019 Apr 20.

Department of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.

Parvoviruses, infecting vertebrates and invertebrates, are a family of single-stranded DNA viruses with small, non-enveloped capsids with T = 1 icosahedral symmetry. A quarter of a century after the first parvovirus capsid structure was published, approximately 100 additional structures have been analyzed. This first structure was that of Canine Parvovirus, and it initiated the practice of structure-to-function correlation for the family. Read More

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https://www.mdpi.com/1999-4915/11/4/362
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http://dx.doi.org/10.3390/v11040362DOI Listing
April 2019
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Pediatric Pulseless Ventricular Tachycardia: A Simulation Scenario for Fellows, Residents, Medical Students, and Advanced Practitioners.

MedEdPORTAL 2016 Jun 3;12:10407. Epub 2016 Jun 3.

Assistant Professor of Pediatric Critical Care Medicine, Medical College of Wisconsin.

Introduction: Pulseless ventricular tachycardia is an uncommon presentation to the pediatric emergency department (ED) or the pediatric ICU (PICU); however, if unrecognized or inappropriately treated, it can lead to significant morbidity and mortality. This resource was created to simulate a high-acuity and low-frequency event targeting PICU fellows, pediatric emergency medicine fellows, pediatric residents, ED residents, medical students, and advanced nursing providers.

Methods: This scenario details the case of a 12-year-old boy with a history of heart transplant who presents with the chief complaint of dizziness. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464469PMC

Greenland Ice Mapping Project: Ice Flow Velocity Variation at sub-monthly to decadal time scales.

Cryosphere 2018 11;12(7):2211-2227. Epub 2018 Jul 11.

Byrd Polar and Climate Research Center, Ohio State University, 1090 Carmack Road, Columbus, OH 43210, USA.

We describe several new ice velocity maps produced by the Greenland Ice Mapping Project (GIMP) using Landsat 8 and Copernicus Sentinel 1A/B data. We then focus on several sites where we analyse these data in conjunction with earlier data from this project, which extend back to the year 2000. At Jakobshavn Isbrae and Koge Bugt, we find good agreement when comparing results from different sensors. Read More

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http://dx.doi.org/10.5194/tc-12-2211-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469699PMC

Basophil involvement in lupus nephritis: a basis for innovation in daily care.

Nephrol Dial Transplant 2018 Jul 25. Epub 2018 Jul 25.

Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252, Université Paris Diderot, Sorbonne Paris Cité, Faculté de Médecine site Bichat, Laboratoire d'Excellence Inflamex, DHU FIRE, Paris, France.

Lupus nephritis (LN) affects a large proportion of patients with systemic lupus erythematosus (SLE). LN can lead to end-stage renal disease depending on when it is diagnosed and on the adequacy of the treatment administered to the patient based on the class of LN. Determination of the class and activity of LN is only possible by histological analysis of kidney biopsies. Read More

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http://dx.doi.org/10.1093/ndt/gfy245DOI Listing

Antibacterial activity study of 1,2,4-triazole derivatives.

Eur J Med Chem 2019 Apr 16;173:274-281. Epub 2019 Apr 16.

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, PR China. Electronic address:

Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.043DOI Listing
April 2019
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Role of nuclear RNA in regulating chromatin structure and transcription.

Curr Opin Cell Biol 2019 Apr 19;58:120-125. Epub 2019 Apr 19.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

The importance of three-dimensional chromatin organisation in genome regulation has never been clearer. But in spite of the enormous technological advances to probe chromatin organisation in vivo, there is still a lack of mechanistic understanding of how such an arrangement is achieved. Here we review emerging evidence pointing to an intriguing role of nuclear RNA in shaping large-scale chromatin structure and regulating genome function. Read More

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http://dx.doi.org/10.1016/j.ceb.2019.03.007DOI Listing

Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy.

Drug Discov Today 2019 Apr 19. Epub 2019 Apr 19.

Centre for Biosystems and Genome Network Medicine, Ioannina University, Ioannina, Greece; Department of Surgery, Ioannina University Hospital, Ioannina, Greece; Department of Systems Biology, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. Electronic address:

Progress in understanding and overcoming fatal intrinsic and acquired resistance is slow, with only a few exceptions. Despite advances in modern genome and transcriptome analysis, the controversy of the three different theories on drug resistance and tumor progression, namely dynamic intratumor heterogeneity, pre-existing minor genomic clones and tumor ecosystem, is unresolved. Moreover, evidence on transcriptional heterogeneity suggests the necessity of a drug bank for individualized, precise drug-sensitivity prediction. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.04.008DOI Listing

Recent advances in gelatin-based therapeutics.

Expert Opin Biol Ther 2019 Apr 22. Epub 2019 Apr 22.

a NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7 , Vitoria-Gasteiz 01006 , Spain .

Introduction: Biomaterials have provided a wide range of exciting opportunities in tissue engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has been extensively used in regenerative medicine applications over the years, due to its cell-responsive properties and the capacity to deliver a wide range of biomolecules. Areas covered: The most relevant properties of gelatin as biomaterial are presented together with its main therapeutic applications. Read More

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http://dx.doi.org/10.1080/14712598.2019.1610383DOI Listing