1,368 results match your criteria Advances In Clinical And Experimental Medicine[Journal]


The assessment of phonatory and ventilatory functions in patients after microsurgery for Reinke's edema.

Adv Clin Exp Med 2020 Jul 3. Epub 2020 Jul 3.

Nofer Institute of Occupational Medicine, Department of Audiology and Phoniatrics, Łódź, Poland.

Background: Short and long-term results of microsurgical treatment with the mini-microflap technique in patients with Reinke's edema (RE) were assessed based on the phonatory and ventilatory functions of the larynx.

Objectives: To assess the short and long-term results of microsurgical treatment with the mini-microflap technique in patients with RE based on the phonatory and ventilatory functions of the larynx.

Material And Methods: Twenty patients diagnosed with advanced stage of RE confirmed with laryngovideostroboscopy (LVS) were enrolled in the study. Read More

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http://dx.doi.org/10.17219/acem/116755DOI Listing

The role of GLP-1/GIP receptor agonists in Alzheimer's disease.

Adv Clin Exp Med 2020 Jun;29(6):661-668

Department of Geriatrics, Second Affiliated Hospital of the Harbin Medical University, China.

Background: New glucagon-like peptide-1 (GLP-1) analogues developed in recent years have a long half-life and offer further prospects for clinical application. At present, the neuroprotection of GLP-1 analogues in Alzheimer's disease (AD) has just begun to be explored.

Objectives: To investigate how glucagon-like peptide-1 (liraglutide) plays a protective role in AD by regulating tau activation and BACE1 expression. Read More

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http://dx.doi.org/10.17219/acem/121007DOI Listing

MicroRNA-548k upregulates a spliced variant of human CD2-associated protein by targeting its promoter.

Adv Clin Exp Med 2020 06;29(6):677-682

Department of Pediatrics, First Affiliated Hospital, Nanjing Medical University, China.

Background: MicroRNAs (miRNAa) regulate gene expression by repressing the translation or directing the degradation of mRNA in the cytoplasm. However, recent studies have shown that miRNAs act to regulate transcription at target gene promoters.

Objectives: To investigate whether miR-548k regulates CD2AP002 expression at the transcriptional level. Read More

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http://dx.doi.org/10.17219/acem/122168DOI Listing

Application of 3D-FS-SPGR imaging combined synovial fluid GGCX detection in the evaluation of knee osteoarthritis.

Adv Clin Exp Med 2020 Jun;29(6):701-706

Department of Orthopedics, Autonomous Region People's Hospital of Ningxia Medical University, China.

Background: Osteoarthritis represents a kind of chronic and degenerative joint disease characterized by articular cartilage injury and osteoproliferation. Osteoarthritis especially poses a serious threat to the elderly patients. At present, the diagnosis of osteoarthritis mainly consists of clinical examination, X-ray examination, magnetic resonance imaging (MRI), and arthroscopy. Read More

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http://dx.doi.org/10.17219/acem/121522DOI Listing

Relationship between serum potassium level and survival outcome in out-of-hospital cardiac arrest using CAPTURES database of Korea: Does hypokalemia have good neurological outcomes in out-of-hospital cardiac arrest?

Adv Clin Exp Med 2020 Jun;29(6):727-734

Department of Emergency Medicine, Kyung Hee University Hospital at Gangdong, South Korea.

Background: Sudden cardiac arrest is a major cause of death worldwide. Serum potassium level is an initial laboratory test that serves as part of an electrolyte panel easily obtainable by most emergency departments (EDs).

Objectives: To evaluate the relationship between serum potassium level and the survival outcome for out-of-hospital cardiac arrest (OHCA) patients. Read More

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http://dx.doi.org/10.17219/acem/122178DOI Listing

Current management of pediatric appendicitis: A Central European survey.

Adv Clin Exp Med 2020 06;29(6):745-750

Department of Pediatric Surgery and Urology, Wroclaw Medical University, Poland.

Background: Appendicitis is one of the most common diagnoses in pediatric populations. Although new recommendations for the treatment of pediatric appendicitis were published, management varies among different institutions.

Objectives: To determine current practices in 4 (n = 4) representative pediatric surgical departments in Central Europe. Read More

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http://dx.doi.org/10.17219/acem/122176DOI Listing

Detecting tumor-infiltrating Forkhead box P3-positive T cells in the prognosis of lung adenocarcinoma: Possible role of clustering tumor interleukin-12 subunit alpha and transforming growth factor beta 1 expression.

Adv Clin Exp Med 2020 Jun;29(6):715-725

Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Japan.

Background: While regulatory T cells (Tregs) are a poor prognostic factor for lung cancer, they may be detected as Forkhead box P3+ (FOXP3+) and cluster of differentiation (-CD) 4+ T cells by classifying FOXP3+CD4+ T cells into different subpopulations of CD4 cells.

Objectives: To classify clusters of tumor-infiltrating Tregs in lung adenocarcinoma based on the mRNA expression levels of interleukin-12 subunit alpha (IL12A) and transforming growth factor beta 1 (TGFB1) in tumor specimens.

Material And Methods: Seventy-nine patients with lung adenocarcinoma were evaluated in this study. Read More

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http://dx.doi.org/10.17219/acem/121922DOI Listing

Large animals as models of atrial fibrillation.

Adv Clin Exp Med 2020 Jun;29(6):757-767

Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Poland.

In clinical practice, atrial fibrillation (AF) is the most common cardiac arrhythmia in humans and it may lead to numerous complications, including central nervous system embolism. The electrical activity of the heart in AF is rapid and chaotic, while the atrioventricular conduction leads to irregular ventricular contraction. Consequently, the stroke volume is reduced, which may lead to symptoms of heart failure. Read More

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http://dx.doi.org/10.17219/acem/122130DOI Listing

Isoflurane cerebral preconditioning in a spontaneous hypertension rat model is associated with sphingosine kinases.

Adv Clin Exp Med 2020 06;29(6):695-700

Department of Nephrology, First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Isoflurane preconditioning could reduce different kinds of brain injury via sphingosine kinase (SPK). Both sphingosine kinase 1 and sphingosine kinase 2 play important roles in brain protection. However, the effects of isoflurane preconditioning on SPK expression in hypertension have not been investigated before. Read More

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http://dx.doi.org/10.17219/acem/121944DOI Listing

The small heterodimer partner inhibits activation of hepatic stellate cells via autophagy.

Adv Clin Exp Med 2020 Jun;29(6):683-693

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai Institute of Liver Diseases, China.

Background: Hepatic fibrosis is a health concern worldwide, and it is of great importance to develop effective therapeutic targets. The small heterodimer partner (SHP) is a regulator of lipid and bile acid metabolism in the liver.

Objectives: The objective of this study was to investigate the contribution of SHP to hepatic fibrosis and the underlying mechanism. Read More

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http://dx.doi.org/10.17219/acem/122175DOI Listing

Oral cancer: The first symptoms and reasons for delaying correct diagnosis and appropriate treatment.

Adv Clin Exp Med 2020 Jun;29(6):735-743

Department of Maxillofacial Surgery, Wroclaw Medical University Hospital, Poland.

Background: The first symptoms of oral cancer are nonspecific. They raise suspicions of other, less serious conditions. Treatment of oral cancer is challenging, and the time of its detection and the implementation of appropriate therapy affect the prognosis. Read More

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http://dx.doi.org/10.17219/acem/116753DOI Listing

Streptococcus agalactiae and Chlamydia trachomatis detection in women without symptoms of infection.

Adv Clin Exp Med 2020 Jun;29(6):707-713

Department of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, Poland.

Background: Chlamydia trachomatis (C. trachomatis) and Streptococcus agalactiae (GBS) may be present in the female cervical canal without any symptoms of infection. Chronic chlamydial infections lead to many serious complications and perinatal infections, while the presence of GBS is a reservoir for infections of newborns or invasive streptococcal infection in adults. Read More

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http://dx.doi.org/10.17219/acem/122397DOI Listing

In vivo delivery of MMP3-shRNA and Sox9 lentivirus cocktail enhances matrix synthesis to prevent lumbar disc degeneration.

Adv Clin Exp Med 2020 Jun;29(6):639-647

Department of Orthopedics, Affiliated Hospital of Qingdao University, China.

Background: Intervertebral disc degeneration (IDD) is characterized by increased proteolytic degradation of the extracellular matrix (ECM), leading to a loss of collagen II and proteoglycan in the nucleus pulposus (NP). Although MMP3 has been reported to play a central role in disc degeneration, it is still unknown whether gene therapy targeting MMP3 can inhibit IDD.

Objectives: To investigate whether lentivirus-mediated MMP3 knockdown is capable of attenuating IDD. Read More

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http://dx.doi.org/10.17219/acem/121509DOI Listing

Organ of hearing and balance in peri- and postmenopausal women. Effects of hormone replacement therapy on hearing and balance in peri- and post-menopausal women: The current state of knowledge.

Adv Clin Exp Med 2020 Jun;29(6):751-755

Department and Clinic of Otolaryngology Head and Neck Surgery, Wroclaw Medical University, Poland.

Sensory-neural hearing loss in people over 50 - senile deafness - is currently an increasing problem due to the growing proportion of the elderly people in the population. We can find a number of worldwide publications on hearing loss and dizziness in peri-menopausal women, but the data is inconsistent. Reports describing the influence of sex hormones on the ear and its aging are similarly controversial. Read More

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http://dx.doi.org/10.17219/acem/121935DOI Listing

Pruritus in renal transplant recipients: Current state of knowledge.

Adv Clin Exp Med 2020 Jun;29(6):769-772

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland.

Chronic itch (CI) is the most common symptom in dermatology. It is considered a great burden with a large impact on patients' quality of life, interfering with everyday activities. During the course of chronic kidney disease (CKD) many patients develop end-stage renal disease (ESRD)-associated CI (ESRDCI). Read More

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http://dx.doi.org/10.17219/acem/122174DOI Listing

The development and evaluation of a multi-epitope antigen as a serodiagnostic marker of Toxoplasma gondii infection.

Adv Clin Exp Med 2020 Jun;29(6):669-675

Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Toxoplasma gondii (T. gondii) is a ubiquitous protozoan parasite which causes a serious disease called toxoplasmosis. The high prevalence of T. Read More

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http://dx.doi.org/10.17219/acem/104554DOI Listing

Weighted gene co-expression network analysis to investigate the key genes implicated in global brain ischemia/reperfusion injury in rats.

Adv Clin Exp Med 2020 Jun;29(6):649-659

Department of Rehabilitation Medicine, Shanghai General Hospital, Shanghai Jiaotong University, China.

Background: Ischemia/reperfusion (I/R) refers to situations where blood is perfused into ischemic or hypoxic tissues, potentially resulting in an inflammatory response and oxidative injury.

Objectives: This study was conducted to explore the pathogenesis of I/R injury.

Material And Methods: GSE82146 was extracted from the Gene Expression Omnibus, consisting of 15 complete global brain ischemia (CGBI) reperfusion hippocampus samples and 12 non-ischemic control (NIC) hippocampus samples. Read More

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http://dx.doi.org/10.17219/acem/121918DOI Listing

A long-term follow-up study on biochemical and clinical biomarkers of response to interferon beta-1b treatment in relapsing-remitting multiple sclerosis.

Adv Clin Exp Med 2020 Jun 5. Epub 2020 Jun 5.

Department of Neurochemistry and Neuropathology, Department of Neurology, Poznan University of Medical Sciences, Poland.

Background: While interferon beta-1b (IFN-β-1b) is still a commonly used disease-modifying drug in the treatment of multiple sclerosis (MS), therapeutic possibilities are expanding, and treatment failure should be identified early. Markers to predict response to IFN-β-1b, either clinical or biochemical, are therefore urgently needed. Interferon-induced proteins, including viperin, suppressor of cytokine signaling 3 (SOCS3), ubiquitin specific peptidase-18 (USP18), and myxovirus resistance protein A (MxA), are possible markers of IFN-β-1b bioavailability and treatment response. Read More

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http://dx.doi.org/10.17219/acem/121063DOI Listing
June 2020
0.333 Impact Factor

Expressions of miR-122a and miR-3195 in laryngeal cancer and their effects on the proliferation and apoptosis of laryngeal cancer cell Hep-2.

Adv Clin Exp Med 2020 May;29(5):525-534

Department of Otorhinolaryngology, and Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, China.

Background: Laryngeal cancer (LC) is one of the common malignant tumors in the head and neck area, and the survival rate for patients is low.

Objectives: To investigate miR-122a and miR-3195 expressions in LC tissue, their correlations with clinicopathological features, and their impacts on Hep-2 proliferation and apoptosis.

Material And Methods: Thirty LC and 20 peritumoral tissue specimens were analyzed. Read More

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http://dx.doi.org/10.17219/acem/118848DOI Listing

Annexin V in children with idiopathic nephrotic syndrome treated with cyclosporine A.

Adv Clin Exp Med 2020 May;29(5):603-609

Department and Clinic of Pediatric Nephrology, Wroclaw Medical University, Poland.

Background: Treatment with cyclosporine A (CsA), a calcineurin inhibitor, is effective in children with difficult idiopathic nephrotic syndrome (INS). Prolonged CsA treatment can result in several adverse effects, the most significant being nephrotoxicity (CsAN). The plasma and urine levels of the proteins annexin V (AnV) and uromodulin (UM) were investigated in order to assess their usefulness as indicators of early-stage CsAN. Read More

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http://dx.doi.org/10.17219/acem/121519DOI Listing

Kidney transplantation and other methods of renal replacement therapy in children: 30 years of observations in one center.

Adv Clin Exp Med 2020 May;29(5):611-613

Department of Pediatric Nephrology, Wroclaw Medical University, Poland.

Background: Kidney transplantation (Tx) is regarded as the optimal treatment method for renal replacement therapy (RRT) for end-stage renal disease (ESRD) patients. Children qualified for Tx should receive the organ as soon as possible in order to improve their chances for healthy development. In our center, RRT for children with ESRD has been conducted for 36 years: hemodialysis (HD) since 1982, peritoneal dialysis (PD) since 1992 and the first transplant in 1987. Read More

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http://dx.doi.org/10.17219/acem/121928DOI Listing

The significance of angiotensin II type 1 receptor (AT1 receptor) in renal transplant injury.

Adv Clin Exp Med 2020 May;29(5):629-633

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Poland.

Humoral response beyond human leukocyte antigen (HLA) is of great interest in the transplant community. We decided to summarize the data on a new antigenic target called angiotensin II type 1 receptor (AT1 receptor). Non-HLA antibodies can now be detected in routine clinical care of patients after transplantation, but their role is not fully understood. Read More

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http://dx.doi.org/10.17219/acem/121510DOI Listing

Efficacy of intra-arterial lidocaine infusion in the treatment of cerulein-induced acute pancreatitis.

Adv Clin Exp Med 2020 May;29(5):587-595

Department of General, Gastroenterological and Endocrine Surgery, Wroclaw Medical University, Poland.

Background: Disturbances in pancreatic microcirculation, beginning with vasoconstriction, are crucial in early pancreatitis and progression to necrotizing pancreatitis. Thus, vascular-targeted treatment aiming to restore a sufficient level of microcirculation through vasodilation would possibly reduce the severity of pancreatitis. Lidocaine is an anti-arrhythmic and local anesthetic drug, which also acts as a vasodilator at higher concentrations. Read More

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http://dx.doi.org/10.17219/acem/121932DOI Listing

Antifungal itraconazole ameliorates experimental autoimmune encephalomyelitis through a novel mechanism of action.

Adv Clin Exp Med 2020 May;29(5):535-545

Department of Neurology, Lishui Hospital, Zhejiang University School of Medicine, Lishui, China.

Background: Multiple sclerosis (MS) is an autoimmune disease characterized by a loss of myelin, limb disabilities and dysregulation of gene expression. Unfortunately, there still is no treatment to cure MS.

Objectives: To explore a novel way to treat MS using currently available antifungal drugs. Read More

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http://dx.doi.org/10.17219/acem/121008DOI Listing

Evaluation of the association between angiotensin converting enzyme insertion/deletion polymorphism and the risk of endometrial cancer in and characteristics of Polish women.

Adv Clin Exp Med 2020 May;29(5):581-585

Institute of Medical Sciences, College of Medical Sciences, University of Rzeszów, Poland.

Background: Endometrial cancer is the most common malignant neoplasm of the female reproductive organs. A dysfunctional endometrial renin-angiotensin system (RAS) might contribute to the growth and spread of endometrial cancer. The RAS-related gene polymorphisms, including the polymorphism of insertion/deletion (I/D) in the angiotensin-converting enzyme (ACE) gene, influence RAS activity. Read More

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http://dx.doi.org/10.17219/acem/118843DOI Listing

Classification algorithm of patients with endometriosis: Proposal for tailored management.

Adv Clin Exp Med 2020 May;29(5):615-622

Gynecology and Obstetrics, Department of Surgical Sciences, City of Health and Science, University of Torino, Italy.

Endometriosis is a pseudoneoplastic disease that has a significant personal and social impact. Unlike other neoplastic diseases, its management is burdened by uncertainty and controversy. The aim of this article is to furnish clinicians with a simple, useful and updated tool to select an appropriate diagnostic-therapeutic care pathway for affected women. Read More

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http://dx.doi.org/10.17219/acem/118849DOI Listing

Macrophage migration inhibitory factor gene polymorphisms as exacerbating factors of apical periodontitis.

Adv Clin Exp Med 2020 May;29(5):597-602

Department of Pharmacy, University of Guanajuato, Mexico.

Background: Two polymorphisms in the macrophage migration inhibitory factor (MIF) gene have been associated with inflammatory diseases (-794 CATT5-8 and -173G>C); however, so far there are no reports of studies related to oral health.

Objectives: To genotype the -794 CATT5-8 and -173G>C MIF polymorphisms in Mexican patients with apical periodontitis as a genetic risk of exacerbation.

Material And Methods: The study involved 120 patients with apical periodontitis: 60 with a diagnosis of acute apical periodontitis (Group A) and 60 without previous episodes of exacerbation (Group B). Read More

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http://dx.doi.org/10.17219/acem/121508DOI Listing

Whole blood ACTB, B2M and GAPDH expression reflects activity of inflammatory bowel disease, advancement of colorectal cancer, and correlates with circulating inflammatory and angiogenic factors: Relevance for real-time quantitative PCR.

Adv Clin Exp Med 2020 May;29(5):547-556

Department of Medical Biochemistry, Wroclaw Medical University, Poland.

Background: The effect of bowel inflammation and cancer on the expression of the most prevalent internal controls: ACTB, GAPDH and B2M in whole blood is unknown, although at least GAPDH occurred to be tightly regulated and suspected of supporting cancer growth, challenging its suitability as a reference.

Objectives: To evaluate the effect of colorectal cancer (CRC) and active inflammatory bowel disease (IBD) on the stability of ACTB, B2M, GAPDH, HPRT1, SDHA, and TBP leukocyte expression.

Material And Methods: Gene expression in controls and CRC and IBD patients (n = 21/18/25) was evaluated in real-time quantitative polymerase chain reaction (RT-qPCR) using NormFinder, geNorm, BestKeeper, and comparative ΔCt method, and validated by comparison with absolute quantification of interleukin 1β (IL-1β) and CCL4. Read More

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http://dx.doi.org/10.17219/acem/118845DOI Listing

Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm.

Adv Clin Exp Med 2020 May;29(5):565-572

Department and Clinic of Cardiac Surgery, Wroclaw Medical University, Poland.

Background: Thoracic aortic aneurysm (TAA) formation is accompanied by degradation of extracellular matrix components (EMC). Numerous matrix metalloproteinases (MMPs) have been implicated in the process, but the involvement of MMP-3 remains unclear. Additionally, the changes in proteoglycan (PG) structure can alter the signal transduction pathways in TAA, though the enzymatic systems which originate them are not fully understood. Read More

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http://dx.doi.org/10.17219/acem/119383DOI Listing

Anatomy-related ratios predict colonoscopy incompleteness in similar examination conditions.

Adv Clin Exp Med 2020 May;29(5):573-580

Institute of Functional and Clinical Anatomy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Background: Screening colonoscopy is one of the most popular modalities for screening and surveillance of colorectal cancer and other colon disorders.

Objectives: To introduce new ratios to predict the colonoscopy course in patients with similar characteristics.

Material And Methods: Five hundred screening colonoscopies (252 females and 248 males) were performed by an experienced endoscopist. Read More

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http://dx.doi.org/10.17219/acem/118847DOI Listing

The role of genetic factors in carpal tunnel syndrome etiology: A review.

Authors:
Andrzej Żyluk

Adv Clin Exp Med 2020 May;29(5):623-628

Clinic of General and Hand Surgery, Pomeranian Medical University in Szczecin, Poland.

The direct causes of idiopathic carpal tunnel syndrome (CTS) still remain obscure. It has been suggested that the pathology of tendons and other connective tissue structures within the carpal tunnel may be involved in its etiology. The objective of this study was to review the literature about the potential role of genetic factors in the etiology of CTS. Read More

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http://dx.doi.org/10.17219/acem/118846DOI Listing

Thermal effect of Er:YAG and Er,Cr:YSGG used for debonding ceramic and metal orthodontic brackets: An experimental analysis.

Adv Clin Exp Med 2020 May;29(5):557-563

Department of Maxillofacial Surgery, Wroclaw Medical University, Poland.

Background: In orthodontics, erbium (Er:YAG) lasers can be used for bracket debonding.

Objectives: To assess the changes in temperature of pulp and enamel during laser debonding of brackets.

Material And Methods: A total of 13 brackets (n = 13; 2 metal and 11 ceramic brackets) were bonded to 13 caries-free premolars extracted for orthodontic reasons. Read More

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http://dx.doi.org/10.17219/acem/118844DOI Listing

Diffusion tensor imaging of normal-appearing cervical spinal cords in patients with multiple sclerosis: Correlations with clinical evaluation and cerebral diffusion tensor imaging changes. Preliminary experience.

Adv Clin Exp Med 2020 Apr;29(4):441-448

Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Background: Several studies have identified changes in the spinal cord DTI measurements in patients with multiple sclerosis (MS). However, correlations between changes in DTI parameters in normal appearing cervical spine and neurological findings have not been clearly established.

Objectives: To determine whether diffusion tensor imaging (DTI) measurements such as fractional anisotropy (FA) and apparent diffusion coefficient (ADC) are sufficiently sensitive in detecting microstructure alterations in normal-appearing spinal cords in patients with MS and whether they reflect these patients' clinical disability. Read More

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http://dx.doi.org/10.17219/acem/116754DOI Listing

Evaluation of the relationship between splenic iron overload and liver, heart and muscle features evident on T2*-weighted magnetic resonance imaging.

Adv Clin Exp Med 2020 Apr;29(4):475-480

Department of Radiology, Medical School, Dicle University, Diyarbakir, Turkey.

Background: Splenic iron overload is the most common clinical condition in patients with thalassemia. However, few studies of the effects of splenectomy have been published.

Objectives: To evaluate the relationship between splenic iron overload and liver, heart and muscle features visible in T2*-weighted magnetic resonance imaging, and to investigate the effects of splenectomy on these tissues in patients with beta-thalassemia major (TM). Read More

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http://dx.doi.org/10.17219/acem/116758DOI Listing

Study of PLGA microspheres loaded with pOsx/PEI nanoparticles for repairing bone defects in vivo and in vitro.

Adv Clin Exp Med 2020 Apr;29(4):431-440

Department of Orthopedics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, China.

Background: Autogenous or allogenic bone transplantation is the main treatment for bone defects and nonunions. However, the shortcomings of autogenous or allogenic bone transplantation limit its wide application in clinical use.

Objectives: This study investigated the effect of poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with pOsterix (pOsx)/polyethylenimine (PEI) nanoparticles in repairing bone defects and explored its mechanism. Read More

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http://dx.doi.org/10.17219/acem/116752DOI Listing

Receptor-mediated attenuation of insulin-like growth factor-1 activity by galactose-1-phosphate in neonate skin fibroblast cultures: Galactosemia pathogenesis.

Adv Clin Exp Med 2020 Apr;29(4):499-504

Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait.

Background: The pathogenesis of classical galactosemia, a rare metabolic disorder associated with developmental complications in neonates and children due to inherited deficiency of galactose-1-phosphate (Gal-1-P) uridylyltransferase (GALT), is known to be mediated by elevated Gal-1-P levels and involves a cascade of cytokines, reactive oxygen species (ROS) and growth factors.

Objectives: To examine ex vivo the effect of Gal-1-P on the mitogenic activity of different growth factors, particularly insulin-like growth factor-1 (IGF-1), known to regulate growth and development from the fetal stage to adulthood.

Material And Methods: Fibroblasts derived from the foreskin of 3-8-day-old healthy neonates were cultured for 1-14 days with 0-20 mM galactose or 0-10 mM Gal-1-P and then stimulated with 5% fetal bovine serum (FBS) or 50 ng/mL of platelet-derived growth factor (PDGF) or fibroblast growth factor (FGF) or IGF-1 for 24 h. Read More

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http://dx.doi.org/10.17219/acem/111807DOI Listing

IgA vasculitis with nephritis in children.

Adv Clin Exp Med 2020 Apr;29(4):513-519

Chair and Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Poland.

Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura (HSP), is the most common form of systemic vasculitis in children. Although the first case of IgAV was described more than 200 years ago, its etiology still remains unclear. Nephrological symptoms are observed in 30-50% of children during the course of the disease, and in up to 91% of cases within 6 weeks of the onset of the first symptoms. Read More

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http://dx.doi.org/10.17219/acem/112566DOI Listing

Mayer-Rokitansky-Küster-Hauser syndrome as an interdisciplinary problem.

Adv Clin Exp Med 2020 Apr;29(4):505-511

1st Department and Clinic of Gynecology and Obstetrics, Wroclaw Medical University, Poland.

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, also known as Müllerian agenesis or aplasia, is a congenital disease manifested by the aplasia of the uterus and the upper 2/3 of the vagina; its incidence is 1 in 4,000-5,000 female live births. We can distinguish 2 types of the MRKH syndrome: type I, which is characterized by an isolated absence of 2/3 of the vagina and uterus; and type II or MURCS (Müllerian duct aplasia, unilateral renal agenesis and cervicothoracic somite anomalies), which is also associated with other symptoms. The treatment of the MRKH syndrome patients aims at creating a neovagina and enabling sexual intercourse. Read More

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http://dx.doi.org/10.17219/acem/118850DOI Listing

Comparative biomechanical testing of customized three-dimensional printing acetabular-wing plates for complex acetabular fractures.

Adv Clin Exp Med 2020 Apr;29(4):459-468

The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.

Background: Three-dimensional (3D) printing of an acetabular wing-plate is a new minimally invasive surgical technique for complex acetabular fractures.

Objectives: To investigate the biomechanical stability of 3D printing acetabular wing-plates. The results were compared with 2 conventional fixation systems. Read More

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http://dx.doi.org/10.17219/acem/116749DOI Listing
April 2020
0.333 Impact Factor

The impact of health education on treatment outcomes in heart failure patients.

Adv Clin Exp Med 2020 Apr;29(4):481-492

Faculty of Health Sciences, Wroclaw Medical University, Poland.

Background: In 2016 heart failure (HF) affected between 600,000 and 700,000 people in Poland being one of the most common causes of hospitalization and death. Health education is an elements of patient treatment aimed at improving the level of self-care and adherence to the treatment recommendations.

Objectives: To perform a systematic review and meta-analysis of the available literature in order to determine the role of health education in HF treatment and its impact on outcomes in patients with chronic HF. Read More

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http://dx.doi.org/10.17219/acem/115079DOI Listing

Social participation of patients with multiple sclerosis.

Adv Clin Exp Med 2020 Apr;29(4):469-473

Clinical Department of Neurology, Wroclaw Medical University, Poland.

Background: The effect multiple sclerosis (MS) has on the social functioning and integration of patients has been recently considered as an important factor of the disease.

Objectives: To assess social participation of MS patients with regard to demographic and disease-related variables.

Material And Methods: The study comprised 201 MS patients: 140 women, 61 men, aged 24-69 years. Read More

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http://dx.doi.org/10.17219/acem/115237DOI Listing

The effect of diabetes on vitreous levels of adiponectin and inflammatory cytokines in experimental rat model.

Adv Clin Exp Med 2020 Apr;29(4):449-452

Etimesgut Public Health Laboratory, Ankara, Turkey.

Background: Diabetic retinopathy is one of the most common eye diseases faced by diabetic patients. It is a slow-progressing complication that results from damage to the blood vessels of the retina.

Objectives: To investigate the role of adiponectin and inflammatory cytokines in the vitreous of diabetic rats. Read More

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http://dx.doi.org/10.17219/acem/115004DOI Listing

The relation of endocan and galectin-3 with ST-segment resolution in patients with ST-segment elevation myocardial infarction.

Adv Clin Exp Med 2020 Apr;29(4):453-458

Department of Cardiology, Faculty of Medicine, Bozok University, Yozgat, Turkey.

Background: ST-segment elevation myocardial infarction (STEMI) remains a leading cause of morbidity and mortality around the world. In patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), electrocardiographic measures of ST-segment resolution (STR) may give information about the myocardial perfusion and poor prognosis.

Objectives: To investigate the relation of endocan and galectin-3 levels with STR in STEMI patients. Read More

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http://dx.doi.org/10.17219/acem/118126DOI Listing

The preservation effect of coronary collateral circulation on left ventricular function in chronic total occlusion and its association with the expression of vascular endothelial growth factor A.

Adv Clin Exp Med 2020 Apr;29(4):493-497

Department of Cardiology, Fudan University Affiliated Zhongshan Hospital, Shanghai, China.

Background: Patients with coronary chronic total occlusion (CTO) typically have collateralization of the distal vessel, and these collaterals can contribute to the relief of ischemia and anginal symptoms and to the preservation of ventricular function.

Objectives: To investigate the preservation effect of coronary collateral circulation on left ventricular (LV) function in coronary CTO, and to explore the potential mechanism behind the development of coronary collateral circulation.

Material And Methods: A total of 102 consecutive patients with coronary CTO were divided into 2 groups: the left ventricular ejection fraction (LVEF)-preserved group (LVEF ≥ 50%; n = 46) and the LVEF-decreased group (LVEF < 50%; n = 56). Read More

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http://dx.doi.org/10.17219/acem/104535DOI Listing
April 2020
0.333 Impact Factor

Single nucleotide polymorphisms of SCN5A and SCN10A genes increase the risk of ventricular arrhythmias during myocardial infarction.

Adv Clin Exp Med 2020 Apr;29(4):423-429

Laboratory of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Monastir, Tunisia.

Background: Coronary artery disease (CAD) and its ultimate consequence - myocardial infarction (MI) - are major causes of sudden cardiac death (SCD). Previous studies have demonstrated the role of genetic polymorphisms in the risk of SCD and ventricular arrhythmia (VA) during MI.

Objectives: To investigate the association between single nucleotide polymorphisms (SNPs) of genes implicated in congenital cardiac arrhythmias and the risk of developing VA in the context of MI. Read More

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http://dx.doi.org/10.17219/acem/116750DOI Listing

Effect of glucocorticoids on the function of microvascular endothelial cells in the human femoral head bone.

Adv Clin Exp Med 2020 Mar;29(3):345-353

Department of Orthopedic Surgery, Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, China.

Background: The pathogenesis of glucocorticoid (GC)-induced osteonecrosis (ON) of the femoral head remains unclear. Recent research has suggested that it is closely associated with injured bone microvascular endothelial cells (BMECs). However, few studies have used BMECs to perform research pertaining ON of the femoral head. Read More

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http://dx.doi.org/10.17219/acem/112602DOI Listing

Estimating brain volume loss after radiation therapy in children treated for posterior fossa tumors (Corpus callosum and whole brain volume changes following radiotherapy in children).

Adv Clin Exp Med 2020 03;29(3):331-337

CRUK Imaging Centre at The Institute of Cancer Research, Sutton, London, UK.

Background: More than half of pediatric tumors of central nervous system (CNS) primarily originate in the posterior fossa and are conventionally treated with radiation therapy (RT).

Objectives: The objective of this study was to establish whether corpus callosum volumes (CCV) and whole brain volumes (WBV) are correlated and to determine the impact of whole-brain lowvs high-dose RT on brain parenchymal volume loss as assessed using each technique.

Material And Methods: Of the 30 identified children (6-12 years) with newly diagnosed posterior fossa tumors treated with cranial RT, including focal and whole-brain RT, suitable imaging was obtained for 23. Read More

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http://dx.doi.org/10.17219/acem/114827DOI Listing

Evaluation of the potential of nanoparticles containing active substances in selected chronic diseases.

Adv Clin Exp Med 2020 Mar;29(3):385-397

Department of Pharmaceutical Technology, Medical University of Silesia in Katowice, Poland.

Currently, over 80% of all deaths result from the incidence of chronic diseases. The challenge of modern medicine is to develop innovative and effective methods of diagnosis and therapy of these disorders. Different types of particles can be obtained with the use of nanotechnology, including nanoliposomes, solid lipid nanoparticles (SLN), nanospheres, dendrimers, as well as carbon nanotubes (CNT) or fullerenes. Read More

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http://dx.doi.org/10.17219/acem/115005DOI Listing

A prospective observational study on perioperative use of antibacterial agents in implant surgery.

Adv Clin Exp Med 2020 Mar;29(3):355-363

Private practice, Lisbon, Portugal.

Background: Dental implant surgery has become routine practice for replacing missing teeth. Little is known about the use of local antisepsis to control the development of bacterial plaque and to facilitate healing, as current practice guidelines do not address this issue.

Objectives: The objectives of this study were to describe antiseptic practices for implant surgery and to assess plaque control at the operative site as well as the investigator's satisfaction. Read More

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http://dx.doi.org/10.17219/acem/115087DOI Listing

Does the status quo have to remain? The current legal issues of transsexualism in Poland.

Adv Clin Exp Med 2020 Mar;29(3):409-417

2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.

Transsexual persons often undergo the process of transition, which is a long, multi-stage procedure. One of the stages, often final, is the lawful reassignment of sex, which is often perceived by transsexual individuals as more meaningful than the medical interventions. The aim of the study was to analyze the current legal situation of transsexual individuals in Poland. Read More

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http://dx.doi.org/10.17219/acem/115294DOI Listing