301,826 results match your criteria Advances In Cement Research[Journal]

Association of selected gene polymorphisms with thermotolerance traits in cattle - A review.

Anim Biosci 2022 Jun 24. Epub 2022 Jun 24.

Beef Cattle Research Station, Indonesian Agency for Agricultural Research and Development, Pasuruan 67184, Indonesia.

Thermal stress due to extreme changes in the thermal environment is a critical issue in cattle production. Many previous findings have shown a decrease in feed intake, milk yield, growth rate, and reproductive efficiency of the cattle when subjected to thermal stress. Therefore, selecting thermo-tolerant animals is the primary goal of the efficiency of breeding programs to reduce those adverse impacts. Read More

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An in-Depth Analysis of Ovarian Cancer: Pathogenesis and Clinical Manifestation.

Drug Res (Stuttg) 2022 Jun 27. Epub 2022 Jun 27.

Department of Pharmacy, Goel Institute of Pharmaceutical Sciences, Lucknow, India.

Ovarian cancer is characterized by the establishment of tolerance, the recurrence of disease, as well as a poor prognosis. Gene signatures in ovarian cancer cells enable cancer medicine research, therapy, prevention, & management problematic. Notwithstanding advances in tumor puncture surgery, novel combinations regimens, and abdominal radiation, which can provide outstanding reaction times, the bulk of gynecological tumor patients suffer from side effects & relapse. Read More

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Mechanical Ventilation during ECMO: Lessons from Clinical Trials and Future Prospects.

Semin Respir Crit Care Med 2022 Jun 27. Epub 2022 Jun 27.

Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.

Acute Respiratory Distress Syndrome (ARDS) accounts for 10% of ICU admissions and affects 3 million patients each year. Despite decades of research, it is still associated with one of the highest mortality rates in the critically ill. Advances in supportive care, innovations in technologies and insights from recent clinical trials have contributed to improved outcomes and a renewed interest in the scope and use of Extracorporeal life support (ECLS) as a treatment for severe ARDS, including high flow veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) and low flow Extracorporeal Carbon Dioxide Removal (ECCO2R). Read More

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Importance of CAR-T cell therapy monitoring using high-throughput assays.

Drug Discov Today 2022 Jun 24. Epub 2022 Jun 24.

Bio-Rad Laboratories, Inc., 2000 Alfred Nobel Drive, Hercules, CA 94547, USA.

Advances in the development of chimeric antigen receptor (CAR)-T cells have undermined the paramount importance of this technology for the success of adoptive T-cell immunotherapy. The bespoke production of autologous CAR-T cells is a lengthy and costly process. Thus, the development of more cost-effective allogeneic 'off-the-shelf' CAR-T cells provides a more readily available treatment option. Read More

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Counteracting aged DNA methylation states to combat ageing and age-related diseases.

Mech Ageing Dev 2022 Jun 24:111695. Epub 2022 Jun 24.

Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy. Electronic address:

DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the genome. Age is one of these factors. Age causes characteristic DNAm changes that are thought to be not only major drivers of normal ageing but also precursors to diseases, cancer being one of these. Read More

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Methodological advances and strategies for high resolution structure determination of cellular protein aggregates.

J Biol Chem 2022 Jun 24:102197. Epub 2022 Jun 24.

Department of Chemistry, University of Waterloo Waterloo ON Canada. Electronic address:

Aggregation of proteins is at the nexus of molecular processes crucial to aging, disease, and employing proteins for biotechnology and medical applications. There has been much recent progress in determining the structural features of protein aggregates that form in cells; yet, owing to prevalent heterogeneity in aggregation, many aspects remain obscure and often experimentally intractable to define. Here we review recent results of structural studies for cell-derived aggregates of normally globular proteins, with a focus on high resolution methods for their analysis and prediction. Read More

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Review: Liposomes in the prophylaxis and treatment of infectious diseases.

Life Sci 2022 Jun 24:120734. Epub 2022 Jun 24.

Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address:

Infectious diseases remain as one of the major burdens among health communities as well as in the general public despite the advances in prevention and treatment. Although vaccination and vector eliminations have greatly prevented the transmission of these diseases, the effectiveness of these strategies is no longer guaranteed as new challenges such as drug resistance and toxicity as well as the missing effective therapeutics arise. Hence, the development of new tools to manage these challenges is anticipated, in which nano technology using liposomes as effective nanostructure is highly considered. Read More

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Chromosome organization in 4D: insights from C. elegans development.

Curr Opin Genet Dev 2022 Jun 24;75:101939. Epub 2022 Jun 24.

Biozentrum, University of Basel, 4056 Basel-Stadt, Switzerland. Electronic address:

Eukaryotic genome organization is ordered and multilayered, from the nucleosome to chromosomal scales. These layers are not static during development, but are remodeled over time and between tissues. Thus, animal model studies with high spatiotemporal resolution are necessary to understand the various forms and functions of genome organization in vivo. Read More

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Diversity and Evolution of Methane-Related Pathways in Archaea.

Annu Rev Microbiol 2022 Jun 27. Epub 2022 Jun 27.

Institut Pasteur, Université Paris Cité, UMR CNRS 6047, Evolutionary Biology of the Microbial Cell, Paris, France; email:

Methane is one of the most important greenhouse gases on Earth and holds an important place in the global carbon cycle. Archaea are the only organisms that use methanogenesis to produce energy and rely on the methyl-coenzyme M reductase (Mcr) complex. Over the last decade, new results have significantly reshaped our view of the diversity of methane-related pathways in the Archaea. Read More

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Engineering the human gut commensal Bacteroides thetaiotaomicron with synthetic biology.

Curr Opin Chem Biol 2022 Jun 24;70:102178. Epub 2022 Jun 24.

Synthetic Biology Group, MIT Synthetic Biology Center, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA; Research Laboratory of Electronics, MIT, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA; Senti Biosciences, 2 Corporate Drive South San Francisco, CA 94080, USA. Electronic address:

The role of the microbiome in health and disease is attracting the attention of researchers seeking to engineer microorganisms for diagnostic and therapeutic applications. Recent progress in synthetic biology may enable the dissection of host-microbiota interactions. Sophisticated genetic circuits that can sense, compute, memorize, and respond to signals have been developed for the stable commensal bacterium Bacteroides thetaiotaomicron, dominant in the human gut. Read More

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[Perception of working environment in the Laboratory of the Bajío's National Medical Center].

Rev Med Inst Mex Seguro Soc 2022 May 2;60(3):258-267. Epub 2022 May 2.

Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, Hospital de Especialidades No. 1, Laboratorio de Análisis Clínicos. León, Guanajuato, México.

Background: Since the development of the concepts of organizational climate and working environment, at the beginning of the 20th century, very important advances have been made to improve and increase the quality of professional performance in the health area. Belonging to an emblematic institution in health services, it is necessary to establish how the working environment is perceived within it.

Objective: To assess the perception of the working environment in the Clinical Analysis Laboratory of the Centro Médico Nacional del Bajío (Bajío's National Medical Center). Read More

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EEGSym: Overcoming Inter-subject Variability in Motor Imagery Based BCIs with Deep Learning.

IEEE Trans Neural Syst Rehabil Eng 2022 Jun 27;PP. Epub 2022 Jun 27.

In this study, we present a new Deep Learning (DL) architecture for Motor Imagery (MI) based Brain Computer Interfaces (BCIs) called EEGSym. Our implementation aims to improve previous state-of-the-art performances on MI classification by overcoming inter-subject variability and reducing BCI inefficiency, which has been estimated to affect 10-50% of the population. This convolutional neural network includes the use of inception modules, residual connections and a design that introduces the symmetry of the brain through the mid-sagittal plane into the network architecture. Read More

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Quantitative analysis of 3D cellular geometry and modeling of the Arabidopsis embryo.

J Microsc 2022 Jun 27. Epub 2022 Jun 27.

Laboratory of Biochemistry, Wageningen University.

As many multicellular organisms, land plants start their life as a single cell, which forms an embryo. Embryo morphology is relatively simple, yet comprises basic tissues and organs, as well as stem cells that sustain post-embryonic development. Being condensed in both time and space, early plant embryogenesis offers an excellent window to study general principles of plant development. Read More

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Applications of Artificial Intelligence and Machine Learning Algorithms to Crystallization.

Chem Rev 2022 Jun 27. Epub 2022 Jun 27.

School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, 15780 Zografou, Greece.

Artificial intelligence and specifically machine learning applications are nowadays used in a variety of scientific applications and cutting-edge technologies, where they have a transformative impact. Such an assembly of statistical and linear algebra methods making use of large data sets is becoming more and more integrated into chemistry and crystallization research workflows. This review aims to present, for the first time, a holistic overview of machine learning and cheminformatics applications as a novel, powerful means to accelerate the discovery of new crystal structures, predict key properties of organic crystalline materials, simulate, understand, and control the dynamics of complex crystallization process systems, as well as contribute to high throughput automation of chemical process development involving crystalline materials. Read More

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Molecular Mechanisms of Hepatic Dysfunction in Sickle Cell Disease: Lessons From The Townes Mouse Model.

Am J Physiol Cell Physiol 2022 Jun 27. Epub 2022 Jun 27.

Pittsburgh Heart, Liver and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Sickle cell disease (SCD) is an autosomal-recessive-genetic disorder that affects ~100,000 Americans and millions of people worldwide. Erythrocyte sickling, vaso-occlusion, sterile inflammation and hemolysis are the major pathophysiological pathways leading to liver injury in SCD. Although hepatic dysfunction affects up to 10-40% of SCD patients, therapeutic approaches to prevent liver injury in SCD are not known, and the molecular mechanisms promoting progressive liver injury in SCD remain poorly understood. Read More

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The AI Will See You Now: Feasibility and Acceptability of a Conversational AI Medical Interviewing System.

JMIR Form Res 2022 Jun 27;6(6):e37028. Epub 2022 Jun 27.

Stanford Healthcare AI Applied Research Team, Division of Primary Care and Population Health, Stanford University School of Medicine, Redwood City, CA, United States.

Background: Primary care physicians (PCPs) are often limited in their ability to collect detailed medical histories from patients, which can lead to errors or delays in diagnosis. Recent advances in artificial intelligence (AI) show promise in augmenting current human-driven methods of collecting personal and family histories; however, such tools are largely unproven.

Objective: The main aim of this pilot study was to evaluate the feasibility and acceptability of a conversational AI medical interviewing system among patients. Read More

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Necroptosis, Pyroptosis, Ferroptosis in Sepsis and Treatment.

Shock 2022 Jun;57(6):161-171

Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Abstract: As a global major health problem and a leading cause of death, sepsis is defined as a failure of homeostasis, which is mainly initiated by an infection and followed by sustained excessive inflammation until immune suppression. Despite advances in the identification and management of clinical sepsis, morbidity, and mortality remain high. In addition, clinical trials have failed to yield promising results. Read More

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Anti-Cancer Activity of Gedunin by Induction of Apoptosis in Human Gastric Cancer AGS Cells.

Appl Biochem Biotechnol 2022 Jun 27. Epub 2022 Jun 27.

College of Health, Binzhou Polytechnic, No. 919, Huanghe 12th Road, 256603, Binzhou City, China.

Currently, gastric cancer is considered one of the major causes of high mortality and morbidity worldwide. Recent advances in therapeutics, clinical treatment, staging procedures, and imaging techniques are high, yet the prevalence of gastric cancer has not been reduced. Usage of the synthetic drug has many side effects that can lead to other ailments. Read More

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Crosstalk between angiogenesis and immune regulation in the tumor microenvironment.

Arch Pharm Res 2022 Jun 27. Epub 2022 Jun 27.

Vessel-Organ Interaction Research Center, VOICE (MRC), Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, Republic of Korea.

Cancer creates a complex tumor microenvironment (TME) composed of immune cells, stromal cells, blood vessels, and various other cellular and extracellular elements. It is essential for the development of anti-cancer combination therapies to understand and overcome this high heterogeneity and complexity as well as the dynamic interactions between them within the TME. Recent treatment strategies incorporating immune-checkpoint inhibitors and anti-angiogenic agents have brought many changes and advances in clinical cancer treatment. Read More

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Possible Radioprotection of Submandibular Glands in Gamma- Irradiated Rats Using Kaempferol: A Histopathological and Immunohistochemical Study.

Int J Radiat Biol 2022 Jun 27:1-31. Epub 2022 Jun 27.

Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Egypt.

Background & Purpose: Salivary gland damage remains a problem despite advances in radiotherapy schedules for head and neck cancer. Kaempferol, a natural flavonoid, found in several fruits and vegetables, is a good antioxidant. This study was designed to evaluate the possible protective effects of kaempferol on submandibular glands (SMGs) of rats exposed to fractionated gamma irradiation. Read More

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Osteoporosis epidemiology using international cohorts.

Curr Opin Rheumatol 2022 Jun 28. Epub 2022 Jun 28.

Holbæk Hospital, Department of Medicine, Holbæk, Denmark.

Purpose Of Review: To provide an update on the most important new cohort studies within osteoporosis and their bearing on clinical management and directions for future research.

Recent Findings: We identified a collection of new observational cohort studies - including new reports from already established large cohorts - and intervention studies providing new insights into osteoporosis pathophysiology, risk finding, intervention, and treatment barriers.

Summary: Recent cohort studies in osteoporosis highlight the importance of timely identification and treatment of people who are at high risk of suffering osteoporotic fractures. Read More

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DECODE: a computational pipeline to discover T cell receptor binding rules.

Bioinformatics 2022 Jun;38(Supplement_1):i246-i254

IBM Research Europe, 8803 Rüschlikon, Switzerland.

Motivation: Understanding the mechanisms underlying T cell receptor (TCR) binding is of fundamental importance to understanding adaptive immune responses. A better understanding of the biochemical rules governing TCR binding can be used, e.g. Read More

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Self-supervised learning of cell type specificity from immunohistochemical images.

Bioinformatics 2022 Jun;38(Supplement_1):i395-i403

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Motivation: Advances in bioimaging now permit in situ proteomic characterization of cell-cell interactions in complex tissues, with important applications across a spectrum of biological problems from development to disease. These methods depend on selection of antibodies targeting proteins that are expressed specifically in particular cell types. Candidate marker proteins are often identified from single-cell transcriptomic data, with variable rates of success, in part due to divergence between expression levels of proteins and the genes that encode them. Read More

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Mutational Analysis of c-di-GMP-Modulating Genes Reveals Complex Regulation of Motility.

J Bacteriol 2022 Jun 27:e0010922. Epub 2022 Jun 27.

Loyola University Chicagogrid.164971.c, Maywood, Illinois, USA.

The symbiont Vibrio fischeri uses motility to colonize its host. In numerous bacterial species, motility is negatively controlled by cyclic-di-GMP (c-di-GMP), which is produced by diguanylate cyclases (DGCs) with GGDEF domains and degraded by phosphodiesterases with either EAL or HD-GYP domains. To begin to decode the functions of the 50 Vibrio fischeri genes with GGDEF, EAL, and/or HD-GYP domains, we deleted each gene and assessed each mutant's migration through tryptone broth salt (TBS) soft agar medium containing or lacking magnesium (Mg) and calcium (Ca), which are known to influence V. Read More

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The reciprocal relationship between social identification and social support over time: A four-wave longitudinal study.

Br J Soc Psychol 2022 Jun 27. Epub 2022 Jun 27.

Institute of Psychology, University of Hildesheim, Hildesheim, Germany.

It has been argued that the positive effect of a shared social identity on health and well-being critically hinges on the interplay between social identity and social support. This interplay, however, is poorly understood. Building on Haslam et al. Read More

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PRRSV Infection Induces Gasdermin D-Driven Pyroptosis of Porcine Alveolar Macrophages through NLRP3 Inflammasome Activation.

J Virol 2022 Jun 27:e0212721. Epub 2022 Jun 27.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen Universitygrid.12981.33, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, People's Republic of China.

For more than 3 decades, mounting evidence has associated porcine reproductive and respiratory syndrome virus (PRRSV) infection with late-term abortions and stillbirths in sows and respiratory disease in piglets, causing enormous economic losses to the global swine industry. However, to date, the underlying mechanisms of PRRSV-triggered cell death have not been well clarified, especially in the pulmonary inflammatory injury characterized by the massive release of pro-inflammatory factors. Here, we demonstrated that PRRSV infection triggered gasdermin D-mediated host pyroptosis and . Read More

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Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.

Am J Psychiatry 2022 Jun 27:appiajp21101083. Epub 2022 Jun 27.

Karuna Therapeutics, Boston.

Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerability. An unmet need remains for novel, mechanistically unique, and better tolerated therapeutic agents for treating schizophrenia, especially those that treat not only positive symptoms but also the negative and cognitive symptoms of the disease. Almost 25 years ago, the muscarinic acetylcholine receptor (mAChR) agonist xanomeline was reported to reduce psychotic symptoms and improve cognition in patients with Alzheimer's disease. Read More

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TIMSCONVER: A workflow to convert trapped ion mobility data to open data formats.

Bioinformatics 2022 Jun 27. Epub 2022 Jun 27.

Department of Computer Science and Engineering, University of California Riverside, 900 University Ave., Riverside, CA, 92521.

Motivation: Advances in mass spectrometry have led to the development of mass spectrometers with ion mobility spectrometry (IMS) capabilities and dual source instrumentation, however the current software ecosystem lacks interoperability with downstream data analysis using open-source software and pipelines.

Results: Here, we present TIMSCONVERT, a data conversion high-throughput workflow from timsTOF Pro/fleX mass spectrometer raw data files to mzML and imzML formats that incorporates ion mobility data while maintaining compatibility with data analysis tools. We showcase several examples using data acquired across different experiments and acquisition modalities on the timsTOF fleX MS. Read More

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Current trends in image-guided chest interventions.

Respirology 2022 Jun 27. Epub 2022 Jun 27.

Institute for Diagnostic and Interventional Radiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.

Interventional radiology (IR) is a rapidly expanding medical subspecialty and refers to a range of image-guided procedural techniques. The image guidance allows real-time visualization and precision placement of a needle, catheter, wire and device to deep body structures through small incisions. Advantages include reduced risks, faster recovery and shorter hospital stays, lower costs and less patient discomfort. Read More

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Recent Advances of Pore Structure in Disordered Carbons for Sodium Storage: a Mini Review.

Chem Rec 2022 Jun 27:e202200113. Epub 2022 Jun 27.

Institute for Clean Energy & Advanced Materials School of Materials and Energy, Southwest University, Chongqing, 400715, P. R. China.

Disordered carbons as the most promising anode materials for sodium ion batteries (SIBs) have attracted much attention, due to the widely-distributed sources and potentially high output voltage when applied in full cells owing to the almost lowest voltage plateau. The complex microstructure makes the sodium storage mechanism of disordered carbons controversial. Recently, many studies show that the plateau region of disordered carbons are closely related to the embedment of sodium ion/semimetal in nanopores. Read More

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