251 results match your criteria Advances In Carbohydrate Chemistry And Biochemistry[Journal]


Preface.

Authors:
David C Baker

Adv Carbohydr Chem Biochem 2019 ;76:ix-x

Knoxville, TN, United States.

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http://dx.doi.org/10.1016/S0065-2318(19)30022-8DOI Listing
January 2019
1 Read

Sialic Acids in Nonenveloped Virus Infections.

Adv Carbohydr Chem Biochem 2019 7;76:65-111. Epub 2018 Nov 7.

Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany; Vanderbilt University School of Medicine, Nashville, TN, United States.

Sialic acid-based glycoconjugates cover the surfaces of many different cell types, defining key properties of the cell surface such as overall charge or likely interaction partners. Because of this prominence, sialic acids play prominent roles in mediating attachment and entry to viruses belonging to many different families. In this review, we first describe how interactions between viruses and sialic acid-based glycan structures can be identified and characterized using a range of techniques. Read More

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http://dx.doi.org/10.1016/bs.accb.2018.09.004DOI Listing
November 2018

The Biology of Gangliosides.

Authors:
Ronald L Schnaar

Adv Carbohydr Chem Biochem 2019 23;76:113-148. Epub 2018 Oct 23.

Departments of Pharmacology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Gangliosides comprise a varied family of glycosphingolipid structures bearing one or more sialic acid residues. They are found in all mammalian tissues but are most abundant in the brain, where they represent the quantitatively major class of sialoglycans. As prominent molecular determinants on cell surfaces, they function as molecular-recognition partners for diverse glycan-binding proteins ranging from bacterial toxins to endogenous cell-cell adhesion molecules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00652318183000
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http://dx.doi.org/10.1016/bs.accb.2018.09.002DOI Listing
October 2018
7 Reads

Sialic Acids in Neurology.

Adv Carbohydr Chem Biochem 2019 15;76:1-64. Epub 2018 Nov 15.

Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan.

Sialic acid (Sia) is involved in many biological activities and commonly occurs as a monosialyl residue at the nonreducing terminal end of glycoconjugates. The loss of activity of UDP-GlcNAc2-epimerase/ManNAc kinase, which is a key enzyme in Sia biosynthesis, is lethal to the embryo, which clearly indicates the importance of Sia in embryogenesis. Occasionally, oligo/polymeric Sia structures such as disialic acid (diSia), oligosialic acid (oligoSia), and polysialic acid (polySia) occur in glycoconjugates. Read More

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http://dx.doi.org/10.1016/bs.accb.2018.09.003DOI Listing
November 2018

Preface.

Authors:
David C Baker

Adv Carbohydr Chem Biochem 2018 ;75:ix-x

Knoxville, TN, USA.

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http://dx.doi.org/10.1016/S0065-2318(18)30014-3DOI Listing
January 2018
1 Read

Chemical Synthesis of Glycosides of N-Acetylneuraminic Acid.

Adv Carbohydr Chem Biochem 2018 23;75:215-316. Epub 2018 Nov 23.

Department of Chemistry, Southern Illinois University-Edwardsville, Edwardsville, IL, United States.

Investigations of methodologies aimed on improving the stereoselective synthesis of sialosides and the efficient assembly of sialic acid glycoconjugates has been the mission of dedicated research groups from the late 1960s. This review presents major accomplishments in the field, with the emphasis on significant breakthroughs and influential synthetic strategies of the last decade. Read More

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http://dx.doi.org/10.1016/bs.accb.2018.09.005DOI Listing
November 2018

Exploration of the Sialic Acid World.

Adv Carbohydr Chem Biochem 2018 28;75:1-213. Epub 2018 Nov 28.

Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands. Electronic address:

Sialic acids are cytoprotectors, mainly localized on the surface of cell membranes with multiple and outstanding cell biological functions. The history of their structural analysis, occurrence, and functions is fascinating and described in this review. Reports from different researchers on apparently similar substances from a variety of biological materials led to the identification of a 9-carbon monosaccharide, which in 1957 was designated "sialic acid. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00652318183000
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http://dx.doi.org/10.1016/bs.accb.2018.09.001DOI Listing
November 2018
10 Reads

Preface.

Authors:
David C Baker

Adv Carbohydr Chem Biochem 2017 ;74:ix-x

Knoxville, TN, United States.

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http://dx.doi.org/10.1016/S0065-2318(17)30012-4DOI Listing
July 2018
4 Reads

Application of Porous Materials to Carbohydrate Chemistry and Glycoscience.

Authors:
Keith J Stine

Adv Carbohydr Chem Biochem 2017 13;74:61-136. Epub 2017 Nov 13.

University of Missouri-St. Louis, St. Louis, MO, United States.

There is a growing interest in using a range of porous materials to meet research needs in carbohydrate chemistry and glycoscience in general. Among the applications of porous materials reviewed in this chapter, enrichment of glycans from biological samples prior to separation and analysis by mass spectrometry is a major emphasis. Porous materials offer high surface area, adjustable pore sizes, and tunable surface chemistry for interacting with glycans, by boronate affinity, hydrophilic interactions, molecular imprinting, and polar interactions. Read More

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http://dx.doi.org/10.1016/bs.accb.2017.10.002DOI Listing
December 2017
8 Reads

The Synthesis and Biological Characterization of Acetal-Free Mimics of the Tumor-Associated Carbohydrate Antigens.

Adv Carbohydr Chem Biochem 2017 20;74:137-237. Epub 2017 Nov 20.

University of Windsor, Windsor, ON, Canada.

Carcinomas express unique carbohydrates, known as tumor-associated carbohydrate antigens (TACAs), on their surface. These are potential targets for anticancer vaccines; however, to date, no such vaccine has reached the clinic. One factor that may complicate the success of this effort is the lability of the glycosidic bond. Read More

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http://dx.doi.org/10.1016/bs.accb.2017.10.003DOI Listing
December 2017
1 Read

Hyaluronan and Hyaluronan Fragments.

Authors:
Mary K Cowman

Adv Carbohydr Chem Biochem 2017 13;74:1-59. Epub 2017 Nov 13.

Tandon School of Engineering, New York University, New York, NY, United States.

The glycosaminoglycan hyaluronan (HA) is a key component of the microenvironment surrounding cells. In healthy tissues, HA molecules have extremely high molecular mass and consequently large hydrodynamic volumes. Tethered to the cell surface by clustered receptor proteins, HA molecules crowd each other, as well as other macromolecular species. Read More

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http://dx.doi.org/10.1016/bs.accb.2017.10.001DOI Listing
December 2017
4 Reads

Preface.

Authors:
David C Baker

Adv Carbohydr Chem Biochem 2016 ;73:ix-x

The University of Tennessee, Knoxville, Tennessee, USA.

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http://dx.doi.org/10.1016/S0065-2318(16)30013-0DOI Listing
October 2017
7 Reads

Endoglycosidases for the Synthesis of Polysaccharides and Glycoconjugates.

Authors:
Chao Li Lai-Xi Wang

Adv Carbohydr Chem Biochem 2016 23;73:73-116. Epub 2016 Aug 23.

University of Maryland, College Park, MD, United States.

Recent advances in glycobiology have implicated essential roles of oligosaccharides and glycoconjugates in many important biological recognition processes, including intracellular signaling, cell adhesion, cell differentiation, cancer progression, host-pathogen interactions, and immune responses. A detailed understanding of the biological functions, as well as the development of carbohydrate-based therapeutics, often requires structurally well-defined oligosaccharides and glycoconjugates, which are usually difficult to isolate in pure form from natural sources. To meet with this urgent need, chemical and chemoenzymatic synthesis has become increasingly important as the major means to provide homogeneous compounds for functional glycocomics studies and for drug/vaccine development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00652318163000
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http://dx.doi.org/10.1016/bs.accb.2016.07.001DOI Listing
April 2017
3 Reads

Carbohydrate-Processing Enzymes of the Lysosome: Diseases Caused by Misfolded Mutants and Sugar Mimetics as Correcting Pharmacological Chaperones.

Adv Carbohydr Chem Biochem 2016 17;73:225-302. Epub 2016 Oct 17.

Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Graz, Austria.

Lysosomal storage diseases are hereditary disorders caused by mutations on genes encoding for one of the more than fifty lysosomal enzymes involved in the highly ordered degradation cascades of glycans, glycoconjugates, and other complex biomolecules in the lysosome. Several of these metabolic disorders are associated with the absence or the lack of activity of carbohydrate-processing enzymes in this cell compartment. In a recently introduced therapy concept, for susceptible mutants, small substrate-related molecules (so-called pharmacological chaperones), such as reversible inhibitors of these enzymes, may serve as templates for the correct folding and transport of the respective protein mutant, thus improving its concentration and, consequently, its enzymatic activity in the lysosome. Read More

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http://dx.doi.org/10.1016/bs.accb.2016.08.002DOI Listing
April 2017
1 Read

Recent Advances Toward Robust N-Protecting Groups for Glucosamine as Required for Glycosylation Strategies.

Adv Carbohydr Chem Biochem 2016 18;73:117-224. Epub 2016 Oct 18.

Faculty of Science, Alexandria University, Alexandria, Egypt; Universität Konstanz, Konstanz, Germany.

2-Amino-2-deoxy-d-glucose (d-glucosamine) is among the most abundant monosaccharides found in natural products. This constituent, recognized for its ubiquity, is presented in most instances as its N-acetyl derivative 2-acetamido-2-deoxy-d-glucopyranose (N-acetylglucosamine, GlcNAc, NAG). It occurs as the β-linked pyranosyl group in polysaccharides and oligosaccharides, and sometimes as the monosaccharide itself, either in its native state or as a glycoconjugate. Read More

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http://dx.doi.org/10.1016/bs.accb.2016.08.001DOI Listing
April 2017
9 Reads

Stevia Glycosides: Chemical and Enzymatic Modifications of Their Carbohydrate Moieties to Improve the Sweet-Tasting Quality.

Adv Carbohydr Chem Biochem 2016 29;73:1-72. Epub 2016 Aug 29.

Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, The Netherlands.

Stevia glycosides, extracted from the leaves of the plant Stevia rebaudiana Bertoni, display an amazing high degree of sweetness. As processed plant products, they are considered as excellent bio-alternatives for sucrose and artificial sweeteners. Being noncaloric and having beneficial properties for human health, they are the subject of an increasing number of studies for applications in food and pharmacy. Read More

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http://dx.doi.org/10.1016/bs.accb.2016.05.001DOI Listing
April 2017
16 Reads
2 Citations
2.100 Impact Factor

Preface.

Authors:
David C Baker

Adv Carbohydr Chem Biochem 2015 ;72:ix-xi

University of Tennessee, Knoxville, Tennessee, USA.

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http://dx.doi.org/10.1016/S0065-2318(15)00014-1DOI Listing
June 2016
1 Read

Human Milk Oligosaccharides (HMOS): Structure, Function, and Enzyme-Catalyzed Synthesis.

Authors:
Xi Chen

Adv Carbohydr Chem Biochem 2015 11;72:113-90. Epub 2015 Nov 11.

Department of Chemistry, University of California, Davis, California, USA.

The important roles played by human milk oligosaccharides (HMOS), the third major component of human milk, in the health of breast-fed infants have been increasingly recognized, as the structures of more than 100 different HMOS have now been elucidated. Despite the recognition of the various functions of HMOS as prebiotics, antiadhesive antimicrobials, and immunomodulators, the roles and the applications of individual HMOS species are less clear. This is mainly due to the limited accessibility to large amounts of individual HMOS in their pure forms. Read More

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http://dx.doi.org/10.1016/bs.accb.2015.08.002DOI Listing
June 2016
6 Reads

Glycosylation of Cellulases: Engineering Better Enzymes for Biofuels.

Adv Carbohydr Chem Biochem 2015 24;72:63-112. Epub 2015 Oct 24.

Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, Colorado, USA.

Cellulose in plant cell walls is the largest reservoir of renewable carbon on Earth. The saccharification of cellulose from plant biomass into soluble sugars can be achieved using fungal and bacterial cellulolytic enzymes, cellulases, and further converted into fuels and chemicals. Most fungal cellulases are both N- and O-glycosylated in their native form, yet the consequences of glycosylation on activity and structure are not fully understood. Read More

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http://dx.doi.org/10.1016/bs.accb.2015.08.001DOI Listing
June 2016
5 Reads

Synthetic Approaches to L-Iduronic Acid and L-Idose: Key Building Blocks for the Preparation of Glycosaminoglycan Oligosaccharides.

Adv Carbohydr Chem Biochem 2015 24;72:21-61. Epub 2015 Oct 24.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.

L-Iduronic acid (IdoA) is an important monosaccharide component of glycosaminoglycans (GAGs) such as heparin, heparan sulfate and dermatan sulfate. GAGs are complex, highly sulfated polysaccharides that mediate a multitude of physiological and pathological processes via their interactions with a range of diverse proteins. The main challenge in the synthesis of GAG oligosaccharides is the efficient gram-scale preparation of IdoA building blocks since neither IdoA nor L-idose is commercially available or readily accessible from natural sources. Read More

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http://dx.doi.org/10.1016/bs.accb.2015.07.001DOI Listing
June 2016
3 Reads

Robert John (Robin) Ferrier: 1932-2013.

Adv Carbohydr Chem Biochem 2015 24;72:2-19. Epub 2015 Oct 24.

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http://dx.doi.org/10.1016/bs.accb.2015.08.003DOI Listing

Serge David: 1921-2014.

Adv Carbohydr Chem Biochem 2014 ;71:2-8

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July 2015
70 Reads

Carbohydrate topics, from a critical and integrating view. Preface.

Authors:
Derek Horton

Adv Carbohydr Chem Biochem 2014 ;71:xi-xiii

Washington, DC; Columbus, Ohio.

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http://dx.doi.org/10.1016/B978-0-12-800128-8.09986-6DOI Listing
July 2015
1 Read

Modulating LPS signal transduction at the LPS receptor complex with synthetic Lipid A analogues.

Adv Carbohydr Chem Biochem 2014 ;71:339-89

Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri, USA. Electronic address:

Sepsis, defined as a clinical syndrome brought about by an amplified and dysregulated inflammatory response to infections, is one of the leading causes of death worldwide. Despite persistent attempts to develop treatment strategies to manage sepsis in the clinical setting, the basic elements of treatment have not changed since the 1960s. As such, the development of effective therapies for reducing inflammatory reactions and end-organ dysfunction in critically ill patients with sepsis remains a global priority. Read More

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http://dx.doi.org/10.1016/B978-0-12-800128-8.00005-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465581PMC

Mechanism-based inhibitors of glycosidases: design and applications.

Adv Carbohydr Chem Biochem 2014 ;71:297-338

Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

This article covers recent developments in the design and application of activity-based probes (ABPs) for glycosidases, with emphasis on the different enzymes involved in metabolism of glucosylceramide in humans. Described are the various catalytic reaction mechanisms employed by inverting and retaining glycosidases. An understanding of catalysis at the molecular level has stimulated the design of different types of ABPs for glycosidases. Read More

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http://dx.doi.org/10.1016/B978-0-12-800128-8.00004-2DOI Listing
July 2015
31 Reads

Nitrogen-containing macrocycles having a carbohydrate scaffold.

Adv Carbohydr Chem Biochem 2014 ;71:227-95

Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland. Electronic address:

Nitrogen-containing macrocyclic compounds (amines, amides, and N-heterocyclic derivatives) are important targets in supramolecular chemistry. This chapter discusses the importance of aza-macrocycles in general and, in particular, those receptors containing sugar unit(s). The combination of a carbohydrate scaffold bearing nitrogen-containing functional groups in macrocyclic molecules opens a convenient route to chiral receptors having potentially useful properties. Read More

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http://dx.doi.org/10.1016/B978-0-12-800128-8.00003-0DOI Listing
July 2015
5 Reads

Chemical synthesis of saponins.

Adv Carbohydr Chem Biochem 2014 ;71:137-226

State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, PR China. Electronic address:

Saponins are a large family of amphiphilic glycosides of steroids and triterpenes found in plants and some marine organisms. By expressing a large diversity of structures on both sugar chains and aglycones, saponins exhibit a wide range of biological and pharmacological properties and serve as major active principles in folk medicines, especially in traditional Chinese medicines. Isolation of saponins from natural sources is usually a formidable task due to the microheterogeneity of saponins in Nature. Read More

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http://dx.doi.org/10.1016/B978-0-12-800128-8.00002-9DOI Listing
July 2015
7 Reads

Carbohydrate-protein interactions: molecular modeling insights.

Adv Carbohydr Chem Biochem 2014 ;71:9-136

Department of Chemistry, Slovak Academy of Sciences, Bratislava, Slovak Republic; Department of Chemistry, Faculty of Natural Sciences, Constantine The Philosopher University, Nitra, Slovak Republic. Electronic address:

The article reviews the significant contributions to, and the present status of, applications of computational methods for the characterization and prediction of protein-carbohydrate interactions. After a presentation of the specific features of carbohydrate modeling, along with a brief description of the experimental data and general features of carbohydrate-protein interactions, the survey provides a thorough coverage of the available computational methods and tools. At the quantum-mechanical level, the use of both molecular orbitals and density-functional theory is critically assessed. Read More

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http://dx.doi.org/10.1016/B978-0-12-800128-8.00001-7DOI Listing
July 2015
4 Reads

Preface.

Authors:
Derek Horton

Adv Carbohydr Chem Biochem 2013 ;70:ix-xi

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http://dx.doi.org/10.1016/B978-0-12-408092-8.09999-7DOI Listing
September 2014
1 Read

Seven decades of "advances".

Authors:
Derek Horton

Adv Carbohydr Chem Biochem 2013 ;70:13-209

Department of Chemistry, Ohio State University, Columbus, Ohio, USA; Department of Chemistry, American University, Washington, District of Columbia, USA.

The field of carbohydrate science, as documented in the 70 volumes of Advances in Carbohydrate Chemistry (and Biochemistry) during the years 1944 through 2014, is surveyed. Subject areas detailed in individual volumes cover a broad range to include fundamental structural studies, synthesis, reactivity, mechanisms, analytical methodology, enzymology, biological and medicinal applications, food technology, and industrial and commercial aspects. The contributions of many prominent research leaders in the carbohydrate field are recorded in biographical memoirs. Read More

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http://dx.doi.org/10.1016/B978-0-12-408092-8.00003-3DOI Listing
September 2014
1 Read

Different aspects of new developments in the carbohydrate field. Preface.

Authors:
Derek Horton

Adv Carbohydr Chem Biochem 2013 ;69:xi-xiii

Washington, DC.

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http://dx.doi.org/10.1016/B978-0-12-408093-5.09995-0DOI Listing

Bacterial cell-envelope glycoconjugates.

Adv Carbohydr Chem Biochem 2013 ;69:209-72

Department of NanoBiotechnology, NanoGlycobiology Unit, University of Natural Resources and Life Sciences, Vienna, Austria.

Prokaryotic glycosylation fulfills an important role in maintaining and protecting the structural integrity and function of the bacterial cell wall, as well as serving as a flexible adaption mechanism to evade environmental and host-induced pressure. The scope of bacterial and archaeal protein glycosylation has considerably expanded over the past decade(s), with numerous examples covering the glycosylation of flagella, pili, glycosylated enzymes, as well as surface-layer proteins. This article addresses structure, analysis, function, genetic basis, biosynthesis, and biomedical and biotechnological applications of cell-envelope glycoconjugates, S-layer glycoprotein glycans, and "nonclassical" secondary-cell wall polysaccharides. Read More

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http://dx.doi.org/10.1016/B978-0-12-408093-5.00006-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396862PMC
June 2014
1 Read

Recent advances toward the development of inhibitors to attenuate tumor metastasis via the interruption of lectin-ligand interactions.

Adv Carbohydr Chem Biochem 2013 ;69:125-207

Alberta Glycomics Centre, Department of Chemistry, University of Calgary, Calgary, Alberta, Canada.

Aberrant glycosylation is a well-recognized phenomenon that occurs on the surface of tumor cells, and the overexpression of a number of ligands (such as TF, sialyl Tn, and sialyl Lewis X) has been correlated to a worse prognosis for the patient. These unique carbohydrate structures play an integral role in cell-cell communication and have also been associated with more metastatic cancer phenotypes, which can result from binding to lectins present on cell surfaces. The most well studied metastasis-associated lectins are the galectins and selectins, which have been correlated to adhesion, neoangiogenesis, and immune-cell evasion processes. Read More

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http://dx.doi.org/10.1016/B978-0-12-408093-5.00005-8DOI Listing

De novo asymmetric synthesis of the pyranoses: from monosaccharides to oligosaccharides.

Adv Carbohydr Chem Biochem 2013 ;69:55-123

Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.

The various methods for the de novo asymmetric synthesis of the pyranose sugars are surveyed. The presentation begins with the work of Masamune and Sharpless with the use of the Sharpless asymmetric epoxidation for the synthesis of all eight l-hexoses. The development of other asymmetric reactions and their application for the synthesis of specific hexopyranoses are further discussed. Read More

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http://dx.doi.org/10.1016/B978-0-12-408093-5.00004-6DOI Listing
June 2014
6 Reads

Carbohydrate science. Preface.

Authors:
Derek Horton

Adv Carbohydr Chem Biochem 2012 ;68:xi-xii

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http://dx.doi.org/10.1016/B978-0-12-396523-3.09988-7DOI Listing
April 2013
1 Read

Enzymatic conversions of starch.

Adv Carbohydr Chem Biochem 2012 ;68:59-436

Krakow College of Health Promotion, Poland.

This article surveys methods for the enzymatic conversion of starch, involving hydrolases and nonhydrolyzing enzymes, as well as the role of microorganisms producing such enzymes. The sources of the most common enzymes are listed. These starch conversions are also presented in relation to their applications in the food, pharmaceutical, pulp, textile, and other branches of industry. Read More

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http://dx.doi.org/10.1016/B978-0-12-396523-3.00001-4DOI Listing
April 2013
3 Reads

Molecular architecture and therapeutic potential of lectin mimics.

Adv Carbohydr Chem Biochem 2012 ;68:1-58

Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, Japan.

Lectins are proteins of non-immune origin that bind specific carbohydrates without chemical modification. Coupled with the emerging biological and pathological significance of carbohydrates, lectins have become extensively used as research tools in glycobiology. However, lectin-based drug development has been impeded by high manufacturing costs, low chemical stability, and the potential risk of initiating an unfavorable immune response. Read More

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http://dx.doi.org/10.1016/B978-0-12-396523-3.00002-6DOI Listing
April 2013
4 Reads

Nathan Sharon: 1925-2011.

Adv Carbohydr Chem Biochem 2012 ;67:2-18

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November 2012
3 Reads

Carbohydrates. Preface.

Authors:
Derek Horton

Adv Carbohydr Chem Biochem 2012 ;67:xi-xii

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http://dx.doi.org/10.1016/B978-0-12-396527-1.00006-1DOI Listing
November 2012
1 Read

Effect of protein dynamics and solvent in ligand recognition by promiscuous aminoglycoside-modifying enzymes.

Adv Carbohydr Chem Biochem 2012 ;67:221-48

Department of Biochemistry, Cellular and Molecular Biology, The University of Tennessee, Knoxville, TN, USA.

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http://dx.doi.org/10.1016/B978-0-12-396527-1.00005-XDOI Listing
November 2012
15 Reads

Chemical synthesis of glycosylphosphatidylinositol anchors.

Adv Carbohydr Chem Biochem 2012 ;67:137-219

Department of Chemistry, Wayne State University, Detroit, MI, USA.

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http://dx.doi.org/10.1016/B978-0-12-396527-1.00004-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874811PMC
November 2012
4 Reads

Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present.

Adv Carbohydr Chem Biochem 2012 ;67:95-136

Department of Chemistry, Michigan State University, East Lansing, MI, USA.

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http://dx.doi.org/10.1016/B978-0-12-396527-1.00003-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646295PMC
November 2012
1 Read

Combining computational chemistry and crystallography for a better understanding of the structure of cellulose.

Authors:
Alfred D French

Adv Carbohydr Chem Biochem 2012 ;67:19-93

Southern Regional Research Center, U.S. Department of Agriculture, New Orleans, LA, USA.

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http://dx.doi.org/10.1016/B978-0-12-396527-1.00002-4DOI Listing
November 2012

Life and work.

Authors:
Derek Horton

Adv Carbohydr Chem Biochem 2011 ;66:ix-x

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http://dx.doi.org/10.1016/B978-0-12-385518-3.00012-2DOI Listing
March 2012
1 Read

Imino sugars and glycosyl hydrolases: historical context, current aspects, emerging trends.

Adv Carbohydr Chem Biochem 2011 ;66:187-298

Institut für Organische Chemie, Technische Universität Graz, Austria.

Forty years of discoveries and research on imino sugars, which are carbohydrate analogues having a basic nitrogen atom instead of oxygen in the sugar ring and, acting as potent glycosidase inhibitors, have made considerable impact on our contemporary understanding of glycosidases. Imino sugars have helped to elucidate the catalytic machinery of glycosidases and have refined our methods and concepts of utilizing them. A number of new aspects have emerged for employing imino sugars as pharmaceutical compounds, based on their profound effects on metabolic activities in which glycosidases are involved. Read More

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http://dx.doi.org/10.1016/B978-0-12-385518-3.00004-3DOI Listing
March 2012
1 Read

Synthesis and properties of septanose carbohydrates.

Adv Carbohydr Chem Biochem 2011 ;66:121-86

Department of Chemistry, University of Connecticut, Storrs, Connecticut, USA.

Seven-atom ring sugars, called septanoses, are increasingly the focus of scientific inquiries because of their potential biological activities. This article details the synthesis, conformational analysis, and protein-binding properties of septanose carbohydrates. A distinction is drawn between septanoses that are substituted in the 6-position of the ring and those that are not. Read More

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http://dx.doi.org/10.1016/B978-0-12-385518-3.00003-1DOI Listing
March 2012
2 Reads

Detection and structural characterization of oxo-chromium(V)-sugar complexes by electron paramagnetic resonance.

Adv Carbohydr Chem Biochem 2011 ;66:69-120

Departamento de Químico Física-Área Química General, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.

This article describes the detection and characterization of oxo-Cr(V)-saccharide coordination compounds, produced during chromic oxidation of carbohydrates by Cr(VI) and Cr(V), using electron paramagnetic resonance (EPR) spectroscopy. After an introduction into the main importance of chromium (bio)chemistry, and more specifically the oxo-chromium(V)-sugar complexes, a general overview is given of the current state-of-the-art EPR techniques. The next step reviews which types of EPR spectroscopy are currently applied to oxo-Cr(V) complexes, and what information about these systems can be gained from such experiments. Read More

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http://dx.doi.org/10.1016/B978-0-12-385518-3.00002-XDOI Listing
March 2012
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Toward automated glycan analysis.

Adv Carbohydr Chem Biochem 2011 ;65:219-71

Field of Drug Discovery Research, Faculty of Advanced Life Science, Hokkaido University, Kita-ku, Sapporo, Japan.

As drastic structural changes in cell-surface glycans of glycoproteins and glycosphingolipids, as well as serum glycoproteins, are often observed during cell differentiation and cancer progression, it is considered that glycans can be potential candidates for novel diagnostic and therapeutic biomarkers. Although there have been substantial advances in our understanding of the effects of glycosylation on some biological systems, we still do not fully understand the significance and mechanism of glycoform alteration that is widely observed in many human diseases. This is due to the highly complicated structures of the glycans and the extremely tedious and time-consuming processes required for their separation from complex mixtures and their subsequent analysis. Read More

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http://dx.doi.org/10.1016/B978-0-12-385520-6.00005-4DOI Listing
November 2011
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Polysaccharides of the red algae.

Authors:
Anatolii I Usov

Adv Carbohydr Chem Biochem 2011 ;65:115-217

N. D. Zelinsky Institute of Organic Chemistry, Leninskii Prospect 47, Moscow, Russian Federation.

Red algae (Rhodophyta) are known as the source of unique sulfated galactans, such as agar, agarose, and carrageenans. The wide practical uses of these polysaccharides are based on their ability to form strong gels in aqueous solutions. Gelling polysaccharides usually have molecules built up of repeating disaccharide units with a regular distribution of sulfate groups, but most of the red algal species contain more complex galactans devoid of gelling ability because of various deviations from the regular structure. Read More

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http://dx.doi.org/10.1016/B978-0-12-385520-6.00004-2DOI Listing
November 2011
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Potential trehalase inhibitors: syntheses of trehazolin and its analogues.

Adv Carbohydr Chem Biochem 2011 ;65:45-114

Environmental Division, National Institute of Oceanography and Fisheries, Kayet Bey, El Anfoushy, Alexandria, Egypt.

Trehazolin is a natural pseudodisaccharide obtained from Micromonospora strain SANK 62390 and Amycolaptosis trehalostatica, and later on it was found to be widely distributed in microorganisms, insects, plants, and animals. It has received much attention because of its importance as an inhibitor of the enzyme trehalase. This article is focused on the synthesis of natural trehazolin and its analogues, with details of the synthetic methods. Read More

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http://dx.doi.org/10.1016/B978-0-12-385520-6.00003-0DOI Listing
November 2011
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