229,626 results match your criteria Advances In Biochemical Engineering-biotechnology[Journal]


YY1 regulates cancer cell immune resistance by modulating PD-L1 expression.

Drug Resist Updat 2019 Apr 9;43:10-28. Epub 2019 Apr 9.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, United States. Electronic address:

Recent advances in the treatment of various cancers have resulted in the adaptation of several novel immunotherapeutic strategies. Notably, the recent intervention through immune checkpoint inhibitors has resulted in significant clinical responses and prolongation of survival in patients with several therapy-resistant cancers (melanoma, lung, bladder, etc.). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13687646193001
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http://dx.doi.org/10.1016/j.drup.2019.04.001DOI Listing
April 2019
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Targeted protein degradation: elements of PROTAC design.

Curr Opin Chem Biol 2019 Apr 16;50:111-119. Epub 2019 Apr 16.

Molecular, Cellular, and Developmental Biology Department, Yale University, 219 Prospect Street, KBT 400, New Haven, CT, 06511, United States. Electronic address:

Targeted protein degradation using Proteolysis Targeting Chimeras (PROTACs) has emerged as a novel therapeutic modality in drug discovery. PROTACs mediate the degradation of select proteins of interest (POIs) by hijacking the activity of E3 ubiquitin ligases for POI ubiquitination and subsequent degradation by the 26S proteasome. This hijacking mechanism has been used to degrade various types of disease-relevant POIs. Read More

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http://dx.doi.org/10.1016/j.cbpa.2019.02.022DOI Listing

Amino acid conformations control the morphological and chiral features of the self-assembled peptide nanostructures: Young investigators perspective.

J Colloid Interface Sci 2019 Apr 6;548:244-254. Epub 2019 Apr 6.

State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao, China. Electronic address:

Hypothesis: A variety of nanostructures with different chiral features can be self-assembled from short peptides with highly similar sequences. We hypothesize that these supramolecular nanostructures are ruled by the constituent amino acid residues which adopt their conformations under the influence of intra-/inter-molecular interactions during peptide self-assembly.

Approach: Through reviewing recent advances in the self-assembly of short peptides and focusing on the relationship between amino acid conformations, peptide secondary structures and intra-/inter-molecular interactions within the supramolecular architectures, we aim to rationalize the complex interactive processes involved in the self-assembly of short, designed peptides. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.04.019DOI Listing

A Single-Cell RNA Sequencing Profiles the Developmental Landscape of Arabidopsis Root.

Mol Plant 2019 Apr 17. Epub 2019 Apr 17.

National Key Laboratory of Plant Molecular Genetics (NKLPMG), CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology (SIPPE), Shanghai 200032, P. R. China; University of Chinese Academy of Sciences, Shanghai 200032, P. R. China; ShanghaiTech University, Shanghai 200031, P. R. China. Electronic address:

Cells have the inherent heterogeneity. Recent advances in the single-cell gene expression studies enable us to explore transcriptional regulation in dynamic development processes and highly heterogeneous cell populations. Using high-throughput single-cell RNA sequencing (scRNA-seq) assay, we found that the cells in Arabidopsis root are highly heterogeneous in their transcriptomes. Read More

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http://dx.doi.org/10.1016/j.molp.2019.04.004DOI Listing
April 2019
2 Reads

Should we abandon the term〝lone atrial fibrillation〞?

Hellenic J Cardiol 2019 Apr 17. Epub 2019 Apr 17.

(a)Heart Center, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China. Electronic address:

Characterized by lack of evidence of structural heart disease or any secondary causes of atrial fibrillation (AF), "lone AF" used to represent a unique subtype of AF among the young individuals who were under the age of 60. Despite the longstanding definition has been proposed for years, the diagnostic criteria for "lone AF" remain ambiguous. As more contributing factors causing AF are recognized gradually, the validity of the term of 'lone AF' is in question. Read More

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http://dx.doi.org/10.1016/j.hjc.2019.04.005DOI Listing

The impact of recent advances in lipidomics and redox lipidomics on dermatological research.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Medical University of Vienna, Austria; Christian Doppler Laboratory for the Biotechnology of Skin Aging, Vienna, Austria.

Dermatological research is a major beneficiary of the rapidly developing advances in lipid analytic technology and of bioinformatic tools which help to decipher and interpret the accumulating big lipid data. At its interface with the environment, the epidermis develops a blend of lipids that constitutes the epidermal lipid barrier, essential for the protection from water loss and entry of dangerous noxae. Apart from their structural role in the barrier, novel intra- and inter-cellular signaling functions of lipids and their oxidation products have been uncovered in most cutaneous cell types over the last decades, and the discovery rate has been boosted by the advent of high resolution and -throughput mass spectrometric techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849193015
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.019DOI Listing
April 2019
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Recent advances in 3D printing: vascular network for tissue and organ regeneration.

Transl Res 2019 Apr 5. Epub 2019 Apr 5.

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC; Department of Electrical and Computer Engineering, The George Washington University, Washington, DC; Department of Biomedical Engineering, The George Washington University, Washington, DC; Department of Medicine, The George Washington University Medical Center, Washington, DC. Electronic address:

Over the past years, the fabrication of adequate vascular networks has remained the main challenge in engineering tissues due to technical difficulties, while the ultimate objective of tissue engineering is to create fully functional and sustainable organs and tissues to transplant in the human body. There have been a number of studies performed to overcome this limitation, and as a result, 3D printing has become an emerging technique to serve in a variety of applications in constructing vascular networks within tissues and organs. 3D printing incorporated technical approaches allow researchers to fabricate complex and systematic architecture of vascular networks and offer various selections for fabrication materials and printing techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19315244193007
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http://dx.doi.org/10.1016/j.trsl.2019.04.002DOI Listing
April 2019
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Establishing reproductive potential and advances in fertility preservation techniques for XY individuals with DSD (differences in sex development).

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Elizabeth Garrett Anderson UCL Institute of Women's Health, University College London Hospitals, 250 Euston Road, London, NW12PG.

Discordance between gonadal type and gender identity has often led to an assumption of infertility in patients with differences in sex development (DSD). However, there is now greater recognition of fertility being an important issue for this group of patients. Currently, gonadal tissue that may have fertility potential is not being stored for individuals with DSD and, where gonadectomy forms part of management, is often discarded. Read More

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http://dx.doi.org/10.1111/cen.13994DOI Listing

Drugs in Development for Acute Kidney Injury.

Drugs 2019 Apr 19. Epub 2019 Apr 19.

Division of Nephrology, Department of Medicine, University of Virginia Health System, 135 Hospital Drive, Suite 1031, Charlottesville, VA, 22908, USA.

The care of patients with acute kidney injury (AKI) has been limited due to the lack of effective therapeutics that can either prevent AKI during high-risk situations or treat AKI once established. A revolution in the scientific understanding of the pathogenesis of AKI has led to the identification of potential therapeutic targets. These targets include pathways involved in inflammation, cellular repair and fibrosis, cellular metabolism and mitochondrial function, oxidative stress, apoptosis, and hemodynamics and oxygen delivery. Read More

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http://dx.doi.org/10.1007/s40265-019-01119-8DOI Listing

Current advances in haploid stem cells.

Protein Cell 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Diploidy is the typical genomic mode in all mammals. Haploid stem cells are artificial cell lines experimentally derived in vitro in the form of different types of stem cells, which combine the characteristics of haploidy with a broad developmental potential and open the possibility to uncover biological mysteries at a genomic scale. To date, a multitude of haploid stem cell types from mouse, rat, monkey and humans have been derived, as more are in development. Read More

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http://dx.doi.org/10.1007/s13238-019-0625-0DOI Listing

DamMet: ancient methylome mapping accounting for errors, true variants, and post-mortem DNA damage.

Gigascience 2019 Apr;8(4)

Lundbeck Foundation GeoGenetics Center, University of Copenhagen, Øster Voldgade 5-7, 1350K Copenhagen, Denmark.

Background: Recent computational advances in ancient DNA research have opened access to the detection of ancient DNA methylation footprints at the genome-wide scale. The most commonly used approach infers the methylation state of a given genomic region on the basis of the amount of nucleotide mis-incorporations observed at CpG dinucleotide sites. However, this approach overlooks a number of confounding factors, including the presence of sequencing errors and true variants. Read More

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http://dx.doi.org/10.1093/gigascience/giz025DOI Listing

Cell Death and Inflammation - A Vital but Dangerous Liaison.

Trends Immunol 2019 Apr 16. Epub 2019 Apr 16.

Centre for Cell Death, Cancer, and Inflammation, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK. Electronic address:

The immune system has developed multiple ways to fight infection. Yet, it is constantly tasked with overcoming newly developing pathogenic mechanisms of resistance to host immunity. In most mammals, the stimulation of both innate and adaptive immune receptors can result in gene activation and cell death induction by apoptosis and necroptosis. Read More

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http://dx.doi.org/10.1016/j.it.2019.03.006DOI Listing

Reinforcement Learning, Fast and Slow.

Trends Cogn Sci 2019 Apr 16. Epub 2019 Apr 16.

DeepMind, London, UK; University College London, London, UK.

Deep reinforcement learning (RL) methods have driven impressive advances in artificial intelligence in recent years, exceeding human performance in domains ranging from Atari to Go to no-limit poker. This progress has drawn the attention of cognitive scientists interested in understanding human learning. However, the concern has been raised that deep RL may be too sample-inefficient - that is, it may simply be too slow - to provide a plausible model of how humans learn. Read More

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http://dx.doi.org/10.1016/j.tics.2019.02.006DOI Listing

Use of ultrasound and mHealth to improve perinatal outcomes in low and middle income countries.

Semin Perinatol 2019 Mar 16. Epub 2019 Mar 16.

Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.

The explosion of mobile health and portable obstetric ultrasound interventions in low- and middle-income countries (LMIC) reflects the optimism that technology can help reduce persistently high rates of maternal and neonatal mortality and morbidity in these settings. While these technology-driven interventions have had success in improving aspects of antenatal and perinatal care, they have not clearly demonstrated reductions in mortality. The expanding synergy between mobile health (mHealth) and ultrasound technology shows promise to enhance care, but it will likely take combining these technological advances with system-wide approaches that also address referral patterns and infrastructure barriers to improve outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193004
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http://dx.doi.org/10.1053/j.semperi.2019.03.016DOI Listing
March 2019
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High-throughput phenotyping for crop improvement in the genomics era.

Plant Sci 2019 May 12;282:60-72. Epub 2019 Jan 12.

Division of Genetics & Plant Breeding, Faculty of Agriculture (FoA), Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir (SKUAST-K), Wadura Campus, Sopore-193201, Kashmir, India.

Tremendous progress has been made with continually expanding genomics technologies to unravel and understand crop genomes. However, the impact of genomics data on crop improvement is still far from satisfactory, in large part due to a lack of effective phenotypic data; our capacity to collect useful high quality phenotypic data lags behind the current capacity to generate high-throughput genomics data. Thus, the research bottleneck in plant sciences is shifting from genotyping to phenotyping. Read More

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http://dx.doi.org/10.1016/j.plantsci.2019.01.007DOI Listing

Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.

Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were discovered from bacteria, yet many eukaryotic cyclic peptides turned out to be of RiPP origin. Read More

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https://www.mdpi.com/1420-3049/24/8/1541
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http://dx.doi.org/10.3390/molecules24081541DOI Listing
April 2019
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Production of Mesenchymal Stem Cells Through Stem Cell Reprogramming.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea.

Mesenchymal stem cells (MSCs) possess a broad spectrum of therapeutic applications and have been used in clinical trials. MSCs are mainly retrieved from adult or fetal tissues. However, there are many obstacles with the use of tissue-derived MSCs, such as shortages of tissue sources, difficult and invasive retrieval methods, cell population heterogeneity, low purity, cell senescence, and loss of pluripotency and proliferative capacities over continuous passages. Read More

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http://dx.doi.org/10.3390/ijms20081922DOI Listing

Recent Advances in Brillouin Optical Time Domain Reflectometry.

Sensors (Basel) 2019 Apr 18;19(8). Epub 2019 Apr 18.

Key Laboratory of Advanced Transducers and Intelligent Control Systems (Ministry of Education and Shanxi Province), Taiyuan University of Technology, Taiyuan 030024, China.

In the past two decades Brillouin-based sensors have emerged as a newly-developed optical fiber sensing technology for distributed temperature and strain measurements. Among these, the Brillouin optical time domain reflectometer (BOTDR) has attracted more and more research attention, because of its exclusive advantages, including single-end access, simple system architecture, easy implementation and widespread field applications. It is realized mainly by injecting optical pulses into the fiber and detecting the Brillouin frequency shift (BFS), which is linearly related to the change of ambient temperature and axial strain of the sensing fiber. Read More

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http://dx.doi.org/10.3390/s19081862DOI Listing

Quantitative Analysis of Nuclear Lamins Imaged by Super-Resolution Light Microscopy.

Cells 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

The nuclear lamina consists of a dense fibrous meshwork of nuclear lamins, Type V intermediate filaments, and is ~14 nm thick according to recent cryo-electron tomography studies. Recent advances in light microscopy have extended the resolution to a scale allowing for the fine structure of the lamina to be imaged in the context of the whole nucleus. We review quantitative approaches to analyze the imaging data of the nuclear lamina as acquired by structured illumination microscopy (SIM) and single molecule localization microscopy (SMLM), as well as the requisite cell preparation techniques. Read More

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https://www.mdpi.com/2073-4409/8/4/361
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http://dx.doi.org/10.3390/cells8040361DOI Listing
April 2019
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Recent Advances in the Use of Sourdough Biotechnology in Pasta Making.

Foods 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Soil, Plant, and Food Science, University of Bari Aldo Moro, 70126 Bari, Italy.

The growing consumers' request for foods with well-balanced nutritional profile and functional properties promotes research on innovation in pasta making. As a staple food and a common component of diet, pasta can be considered as a vector of dietary fiber, vegetable proteins, vitamins, minerals, and functional compounds. The conventional process for pasta production does not include a fermentation step. Read More

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http://dx.doi.org/10.3390/foods8040129DOI Listing

Recent Advances on Metal-Free, Visible-Light- Induced Catalysis for Assembling Nitrogen- and Oxygen-Based Heterocyclic Scaffolds.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Institute of Organic Chemistry Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.

Heterocycles are important class of structures, which occupy a major space in the domain of natural and bioactive compounds. For this reason, development of new synthetic strategies for their controllable synthesis became of special interests. The development of novel photoredox systems with wide-range application in organic synthesis is particularly interesting. Read More

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http://dx.doi.org/10.3390/molecules24081533DOI Listing

Physiological validation of the decomposition of surface EMG signals.

Authors:
Roger M Enoka

J Electromyogr Kinesiol 2019 Mar 21;46:70-83. Epub 2019 Mar 21.

Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Electronic address:

Advances in technology have ushered in a new era in the measurement and interpretation of surface-recorded electromyographic (EMG) signals. These developments have included improvements in detection systems, the algorithms used to decompose the interference signals, and the strategies used to edit the identified waveforms. To evaluate the validity of the results obtained with this new technology, the purpose of this review was to compare the results achieved by decomposing surface-recorded EMG signals into the discharge times of single motor units with what is known about the rate coding characteristics of single motor units based on recordings obtained with intramuscular electrodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10506411183038
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http://dx.doi.org/10.1016/j.jelekin.2019.03.010DOI Listing
March 2019
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Mapping water and sediment connectivity.

Sci Total Environ 2019 Apr 6;673:763-767. Epub 2019 Apr 6.

Environmental Management Laboratory, Mykolas Romeris University, Atieitis, 20, LT-08303, Lithuania.

Connectivity has become a key issue in the study of processes acting in hydro-geomorphic systems and has strong implications on the understanding of their behaviour. Given the high complexity of hydro-geomorphic systems and the large variety of the processes controlling the efficiency of water and sediment transfer through a catchment, mapping hydrological and sediment connectivity is fundamental to understand the linkages between different parts of the system and the role played by system configuration, natural landforms and man-made structures in favouring or obstacolating the continuity of runoff and sediment pathways. Furthermore, the analysis of changes on connectivity through time can help to investigate the effect of both natural and anthropic disturbance on water and sediment fluxes and associated processes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193159
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.071DOI Listing
April 2019
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Therapeutic advances in the treatment of SLE.

Int Immunopharmacol 2019 Apr 16;72:218-223. Epub 2019 Apr 16.

Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, 139 Middle Renmin Road, Changsha, Hunan 410011, China. Electronic address:

In recent years, the research on the pathogenesis of systemic lupus erythematosus (SLE) has been deepened, from the level of histopathology to the cellular and molecular biology, thus promoting the progress of SLE drug therapeutics. In March 2011, the United States Food and Drug Administration (FDA) approved the humanized monoclonal antibody, Belimumab for the treatment of SLE and put an end to the dilemma of no new drug available to SLE for more than half a century. On the other hand, the continuous evidence-based medical information has enabled rheumatologists to have a more comprehensive and depth understanding of the application of SLE traditional therapies, further improve the treatment strategy of SLE and put forward higher requirements for treatment goals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193047
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http://dx.doi.org/10.1016/j.intimp.2019.03.010DOI Listing
April 2019
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Advanced Stage Non-Small Cell Lung Cancer: Advances in Thoracic Oncology 2018.

J Thorac Oncol 2019 Apr 16. Epub 2019 Apr 16.

Guangdong Lung Cancer Institute; Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences; Guangzhou; China.

In 2018 research in the field of advanced non-small cell lung cancers (NSCLC) led to an expanded reach and impact of immune-checkpoint inhibitors (ICIs) as part of frontline treatment strategy, regardless of histology subtype, while ICI use was extended to include stage III disease, shifting the prognosis of all these patients. This new standard first-line approach opens a gap in standard second-line treatment, and older combinations may again become standard care after progression on ICIs. The characterization of predictive biomarkers, patient selection, the definition of strategies with ICI combinations upon progression on ICIs, as well as prospective evaluation of the efficacy of ICIs in subpopulations (such as patients with poor performance status or brain metastases) represent upcoming challenges in advanced thoracic malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.03.022DOI Listing
April 2019
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The complexity of a monogenic neurodegenerative disease: More than two decades of therapeutic driven research into Niemann-Pick type C disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Department of Biology, Barnard College-Columbia University, New York, NY 10027, United States of America. Electronic address:

Niemann-Pick type C (NP-C) disease is a rare and fatal neurodegenerative disease typified by aberrations in intracellular lipid transport. Cholesterol and other lipids accumulate in the late endosome/lysosome of all diseased cells thereby causing neuronal and visceral atrophy. A cure for NP-C remains elusive despite the extensive molecular advances emanating from the identification of the primary genetic defect in 1997. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.002DOI Listing
April 2019
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Frailty biomarkers in humans and rodents: current approaches and future advances.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Department of Pharmacology, The University of New South Wales, Sydney, Australia. Electronic address:

Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374193003
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http://dx.doi.org/10.1016/j.mad.2019.03.007DOI Listing
April 2019
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Determinants of Infant Feeding Practices Among HIV-Infected Mothers in Urban Kano, Nigeria.

J Hum Lact 2019 Apr 19:890334419835171. Epub 2019 Apr 19.

5 Department of Health Policy and Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Tennessee, USA.

Background: Despite advances in prevention of mother-to-child HIV transmission, infants in Africa remain at risk of HIV acquisition from inappropriate feeding practices.

Research Aims: To assess maternal knowledge and predictors of appropriate infant feeding practices among HIV-infected mothers attending a tertiary facility in Kano, Nigeria.

Method: A cross section of 203 HIV-positive mothers were interviewed using structured, pretested survey questionnaires. Read More

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http://dx.doi.org/10.1177/0890334419835171DOI Listing
April 2019
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Inferring neural circuit structure from datasets of heterogeneous tuning curves.

PLoS Comput Biol 2019 Apr 19;15(4):e1006816. Epub 2019 Apr 19.

Institute of Neuroscience, University of Oregon, Eugene, Oregon, USA.

Tuning curves characterizing the response selectivities of biological neurons can exhibit large degrees of irregularity and diversity across neurons. Theoretical network models that feature heterogeneous cell populations or partially random connectivity also give rise to diverse tuning curves. Empirical tuning curve distributions can thus be utilized to make model-based inferences about the statistics of single-cell parameters and network connectivity. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006816DOI Listing

Heterogeneous Matrix Habitat Drives Species Occurrences in Complex, Fragmented Landscapes.

Am Nat 2019 May 12;193(5):748-754. Epub 2019 Mar 12.

A fundamental tenet of modern ecology and conservation science is the fact that species occurrence in habitat patches can be determined by patch area and isolation. But such island biogeographic models often poorly predict actual species occurrences in structurally complex landscapes that typify most ecosystems. Recent advances in circuit theory have enhanced estimates of species dispersal and can provide powerful ways to predict landscape-scale distribution of species assemblages through integration with island biogeography. Read More

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https://www.journals.uchicago.edu/doi/10.1086/702589
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http://dx.doi.org/10.1086/702589DOI Listing
May 2019
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Statistical uncertainty analysis for small-sample, high log-variance data: Cautions for bootstrapping and Bayesian bootstrapping.

J Chem Theory Comput 2019 Apr 19. Epub 2019 Apr 19.

Recent advances in molecular simulations allow the evaluation of previously unattainable observables, such as rate constants for protein folding. However, these calculations are usually computationally expensive and even significant computing resources may result in a small number of independent estimates spread over many orders of magnitude. Such small-sample, high "log-variance" data are not readily amenable to analysis using the standard uncertainty (i. Read More

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http://dx.doi.org/10.1021/acs.jctc.9b00015DOI Listing

CARDIAC INVOLVEMENT IN Beta-THALASSAEMIA: Current treatment strategies.

Postgrad Med 2019 Apr 19. Epub 2019 Apr 19.

e Department of Medicine , Sultan Qaboos University Hospital , Muscat , Oman.

Despite the advances in the management of thalassaemia major, heart disease remains the leading cause of mortality in patients afflicted with this disorder. Cardiac involvement in thalassaemia encompasses a spectrum of disorders including myocardial dysfunction, arrhythmias, pulmonary hypertension and peripheral vascular disease. Although cardiac siderosis (accumulation of iron in cardiac myocytes) as a consequence of repeated blood transfusions is deemed to be the main aetiologic factor for myocardial dysfunction in transfusion dependent patients, the significance of other pathophysiologic mechanisms is being increasingly recognized especially in non-transfusion dependent patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1608071DOI Listing
April 2019
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Emergency treatment of iatrogenic coronary perforation by transcatheter embolization with gelatin sponge particles-Description of technique.

Catheter Cardiovasc Interv 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, Poznań University of Medical Sciences, Poznan, Poland.

Coronary artery perforation (CAP) is a rare but potentially life-threatening complication of percutaneous coronary intervention (PCI) that requires prompt diagnosis and effective treatment. Importantly, dynamic advances in interventional cardiology reflected by the increasing percentage of more challenging PCIs performed in more complex lesions have resulted in significant changes in CAPs pattern. Herein, we describe a technique and present a case report of CAP that occurred during percutaneous recanalization of the occluded restenotic right coronary artery (RCA) successfully treated with transcatheter embolization using gelatin sponge particles prepared on-site. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccd.28291
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http://dx.doi.org/10.1002/ccd.28291DOI Listing
April 2019
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Correlation and agreement between 2D and 3D speckle-tracking echocardiography for left ventricular volumetric, strain, and rotational parameters in healthy volunteers and in patients with mild mitral stenosis.

Echocardiography 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Research and Training Hospital, Istanbul, Turkey.

Background: Recent advances had allowed measurement of myocardial deformation parameters using 3D speckle-tracking echocardiography (STE). Agreement between these two modalities and interchangeability of findings remain as an issue since 2DSTE is more widely available than 3DSTE. The aim of this study was to investigate the correlation and agreement between 2DSTE and 3DSTE in healthy volunteers and in patients with mild mitral stenosis (MS). Read More

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http://dx.doi.org/10.1111/echo.14336DOI Listing

Epigenetic dynamics during flowering plant reproduction: evidence for reprogramming?

Authors:
Mary Gehring

New Phytol 2019 Apr 19. Epub 2019 Apr 19.

Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.

Over the last ten years there have been major advances in documenting and understanding dynamic changes to DNA methylation, small RNAs, chromatin modifications, and chromatin structure that accompany reproductive development in flowering plants from germline specification to seed maturation. Here I highlight recent advances in the field, mostly made possible by microscopic analysis of epigenetic states or by the ability to isolate specific cell types or tissues and apply omics approaches. I consider in which contexts there is potentially reprogramming vs maintenance or reinforcement of epigenetic states. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/nph.15856
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http://dx.doi.org/10.1111/nph.15856DOI Listing
April 2019
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HOXD-AS1: a novel oncogenic long intergenic non-coding RNA in humans.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2898-2907

Department of Hepatobiliary Surgery, Haikou People's Hospital/Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou, Hainan, P.R. China.

Objective: Long non-coding RNAs are an emerging special class of regulatory RNAs with more than 200 nucleotides that play vital roles in gene regulation, metabolism, drug resistance, cell differentiation, and other processes. These RNAs were also reported to be dysregulated in human disease, especially malignant tumors. However, the underlying mechanisms remain elusive. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17568DOI Listing
April 2019
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[Advances in isopeptide bond-mediated molecular superglue].

Sheng Wu Gong Cheng Xue Bao 2019 Apr;35(4):607-615

College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, Zhejiang, China.

Isopeptide bond-mediated molecular superglue is the irreversible covalent bond spontaneously formed by the side chains of lysine (Lys) and asparagine/aspartic acid (Asn/Asp) residues. The peptide-peptide interaction is specific, stable, and can be achieved quickly without any particular physicochemical factor. In the light of recent progress by domestic and foreign researchers, here we summarize the origin, assembly system and mechanism of isopeptide bond reaction, as well as the molecular cyclization and protein topological structure mediated by it. Read More

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http://dx.doi.org/10.13345/j.cjb.180303DOI Listing

[Advances in microbial enzymatic elimination of ethyl carbamate in Chinese rice wine].

Sheng Wu Gong Cheng Xue Bao 2019 Apr;35(4):567-576

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China.

Ethyl carbamate (EC), a carcinogenic and teratogenic chemical that is widely distributed in various alcoholic beverages, has attracted much attention. Microbial enzymatic degradation of EC in rice wine is always efficient and attractive. In this review, we summarize the research progress and problems of microbial enzymatic elimination of EC in rice wine from three aspects: the mechanisms of EC formation in rice wine, the research progress of acid urease, and the research progress of urethanase. Read More

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http://dx.doi.org/10.13345/j.cjb.180386DOI Listing
April 2019
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Patient-Centeredness during In-Depth Consultation in the Outpatient Clinic of a Tertiary Hospital in Korea: Paradigm Shift from Disease to Patient.

J Korean Med Sci 2019 Apr 22;34(15):e119. Epub 2019 Apr 22.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background: Patient-centered care (PCC) and integrative care approach are widely advocated. However, their implementation usually requires an extended consultation time. Despite significant advances in medical diagnosis and treatment, no studies have examined consultation time and patient centeredness in Korea. Read More

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https://jkms.org/DOIx.php?id=10.3346/jkms.2019.34.e119
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http://dx.doi.org/10.3346/jkms.2019.34.e119DOI Listing
April 2019
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CO -fixing liquid droplets: towards a dissection of the microalgal pyrenoid.

Traffic 2019 Apr 18. Epub 2019 Apr 18.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

CO enters the biosphere via the slow, oxygen-sensitive carboxylase, Rubisco. To compensate, most microalgae saturate Rubisco with its substrate gas through a carbon dioxide concentrating mechanism. This strategy frequently involves compartmentalization of the enzyme in the pyrenoid, a non-membrane enclosed compartment of the chloroplast stroma. Read More

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http://dx.doi.org/10.1111/tra.12650DOI Listing

Innate immune cells orchestrate the repair of sterile injury in the liver and beyond.

Eur J Immunol 2019 Apr 19. Epub 2019 Apr 19.

Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

There is a close association between inflammation and sterile injury, however not all sterile injuries are the same. While a regulated inflammatory response is crucial for proper healing, a dysregulated or non-terminating response leads to disrepair. While immune cells are thought to contribute to the disrepair, they may also be critical for proper healing and as such their actions may dictate the end result. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184748
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http://dx.doi.org/10.1002/eji.201847485DOI Listing
April 2019
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Inconvenient Truths About Human Longevity.

J Gerontol A Biol Sci Med Sci 2019 Apr 17. Epub 2019 Apr 17.

University of Oklahoma.

The rise in human longevity is one of humanity's crowning achievements. While advances in public health beginning in the 19th century initiated the rise in life expectancy, recent gains have been achieved by reducing death rates at middle and older ages. A debate about the future course of life expectancy has been ongoing for the last quarter century. Read More

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http://dx.doi.org/10.1093/gerona/glz098DOI Listing
April 2019
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Overview of Some Recent Advances in Improving Water and Energy Efficiencies in Food Processing Factories.

Front Nutr 2019 2;6:20. Epub 2019 Apr 2.

Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA, United States.

Rapid development of food factories in both developed and developing countries, owing to continued growth in the world population, plays a critical role in the food supply chain, including environmental issues such as pollution, emissions, energy and water consumption, and thus food system sustainability. The objective of this study was to briefly review various environmental aspects of food processing operations, including aquatic, atmospheric, and solid waste generation, and also to discuss several strategies that many companies are using to reduce these negative impacts as well as to improve water and energy efficiency. To obtain higher energy efficiencies in food processing factories, two key operations can play critical roles: non-thermal processing (e. Read More

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http://dx.doi.org/10.3389/fnut.2019.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454086PMC

Assessing Cyberbiosecurity Vulnerabilities and Infrastructure Resilience.

Front Bioeng Biotechnol 2019 29;7:61. Epub 2019 Mar 29.

Argonne National Laboratory (DOE), Strategic Security Sciences Division, Lemont, IL, United States.

The convergence of advances in biotechnology with laboratory automation, access to data, and computational biology has democratized biotechnology and accelerated the development of new therapeutics. However, increased access to biotechnology in the digital age has also introduced additional security concerns and ultimately, spawned the new discipline of cyberbiosecurity, which encompasses cybersecurity, cyber-physical security, and biosecurity considerations. With the emergence of this new discipline comes the need for a logical, repeatable, and shared approach for evaluating facility and system vulnerabilities to cyberbiosecurity threats. Read More

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00061
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http://dx.doi.org/10.3389/fbioe.2019.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455068PMC
March 2019
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Epigenomics and Transcriptomics in the Prediction and Diagnosis of Childhood Asthma: Are We There Yet?

Front Pediatr 2019 2;7:115. Epub 2019 Apr 2.

Division of Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.

Asthma is the most common non-communicable chronic disease of childhood. Despite its high prevalence, to date we lack methods that are both efficient and accurate in diagnosing asthma. Most traditional approaches have been based on garnering clinical evidence, such as risk factors and exposures. Read More

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http://dx.doi.org/10.3389/fped.2019.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454089PMC

Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition.

Front Cell Infect Microbiol 2019 2;9:74. Epub 2019 Apr 2.

Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.

Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this scenario, innovative therapeutic strategies must be employed to restrict resistance. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454102PMC

Presentation Patterns, Diagnostic Markers, Management Strategies, and Outcomes of IgD Multiple Myeloma: A Systematic Review of Literature.

Cureus 2019 Feb 4;11(2):e4011. Epub 2019 Feb 4.

Internal Medicine, The University of Arizona, Tucson, USA.

Immunoglobulin (Ig) D multiple myeloma (MM) is a rare subtype of MM comprising 2% of all the cases. Malignant plasma cell invasion leads to signs and symptoms similar to other subtypes of MM. The synthesis rate of IgD is lower in IgD MM patients, making it very difficult to diagnose compared to other subtypes. Read More

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http://dx.doi.org/10.7759/cureus.4011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450588PMC
February 2019

Recent advances in managing/understanding the metabolic syndrome.

F1000Res 2019 3;8. Epub 2019 Apr 3.

Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14008, Mexico.

The metabolic syndrome (MetS) concept gathers in a single entity a set of metabolic abnormalities that have in common a close relationship with ectopic deposit of lipids, insulin resistance, and chronic low-grade inflammation. It is a valuable teaching tool to help health professionals to understand and integrate the consequences of lipotoxicity and the adverse metabolic consequences of insulin resistance. Also, it is useful to identify subjects with a high risk for having incident type 2 diabetes. Read More

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https://f1000research.com/articles/8-370/v1
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http://dx.doi.org/10.12688/f1000research.17122.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449786PMC
April 2019
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Tuning phonon transport spectrum for better thermoelectric materials.

Sci Technol Adv Mater 2019 21;20(1):10-25. Epub 2018 Dec 21.

Department of Mechanical Engineering, The University of Tokyo, Tokyo, Japan.

The figure of merit of thermoelectric materials can be increased by suppressing the lattice thermal conductivity without degrading electrical properties. Phonons are the carriers for lattice thermal conduction, and their transport can be impeded by nanostructuring, owing to the recent progress in nanotechnology. The key question for further improvement of thermoelectric materials is how to realize ultimate structure with minimum lattice thermal conductivity. Read More

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http://dx.doi.org/10.1080/14686996.2018.1548884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454406PMC
December 2018

Strongly correlated oxides for energy harvesting.

Sci Technol Adv Mater 2018 26;19(1):899-908. Epub 2018 Nov 26.

Department of Physics, Waseda University, Tokyo, Japan.

We review recent advances in strongly correlated oxides as thermoelectric materials in pursuit of energy harvesting. We discuss two topics: one is the enhancement of the ordinary thermoelectric properties by controlling orbital degrees of freedom and orbital fluctuation not only in bulk but also at the interface of correlated oxides. The other topic is the use of new phenomena driven by spin-orbit coupling (SOC) of materials. Read More

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https://www.tandfonline.com/doi/full/10.1080/14686996.2018.1
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http://dx.doi.org/10.1080/14686996.2018.1529524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454405PMC
November 2018
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