252,876 results match your criteria Advances In Astronomy[Journal]


Outcomes and factors associated with early mortality in pediatric post-cardiotomy veno-arterial extracorporeal membrane oxygenation.

Artif Organs 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Mortality and morbidity of children received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support after cardiac surgery remain high despite remarkable advances in medical management and devices. The purpose of this study was to describe outcomes and risk factors of applying VA-ECMO in the surgical pediatric population. We retrospectively analyzed 85 consecutive pediatric patients (aged <18 years) who received post-cardiotomy VA-ECMO from January 2010 to December 2018. Read More

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http://dx.doi.org/10.1111/aor.13773DOI Listing

Interfacial Fracture Toughness Comparison of Three Indirect Resin Composites to Dentin and Polyether Ether Ketone Polymer.

Eur J Dent 2020 Jul 9. Epub 2020 Jul 9.

Department of Restorative Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Objectives:  Advances in laboratory composites and their high wear resistance and fracture toughness have resulted in their growing popularity and increasing use for dental restorations. This study sought to assess the fracture toughness of three indirect composites bonded to dental substrate and polyether ether ketone (PEEK) polymer.

Materials And Methods:  This study was conducted on two groups of dental and polymer substrates. Read More

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http://dx.doi.org/10.1055/s-0040-1713309DOI Listing

Mortality of Patients with Cushing's Disease.

Exp Clin Endocrinol Diabetes 2020 Jul 9. Epub 2020 Jul 9.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Cushing's disease is a rare condition of cortisol excess attributed to a pituitary adenoma with an annual incidence of 1.2-2.4 cases per million population. Read More

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http://dx.doi.org/10.1055/a-1197-6380DOI Listing

Proximal Tubular Transcription Factors in Acute Kidney Injury: Recent Advances.

Nephron 2020 Jul 9:1-3. Epub 2020 Jul 9.

Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York, USA.

The proximal tubule (PT) is a major target in acute kidney injury (AKI), leading to profound changes in PT cell biology. Amongst the genes with early and robust changes in expression are many transcription factors (TFs), which themselves account for other transcriptomic changes. Potentially important TFs are being revealed in large sequencing datasets; however, to understand whether these TFs account for adaptive or maladaptive changes requires further mechanistic studies, which may reveal novel therapeutic targets. Read More

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http://dx.doi.org/10.1159/000508856DOI Listing

Recent advances of thiol-selective bioconjugation reactions.

Curr Opin Chem Biol 2020 Jul 6;58:28-36. Epub 2020 Jul 6.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP), Campus Berlin-Buch, Robert-Roessle-Str. 10, Berlin, D-13125, Germany; Humboldt-Universität zu Berlin, Institut für Chemie, Brook-Taylor-Str.2, Berlin, D-12489, Germany. Electronic address:

Proteins are the most abundant biomolecules within a cell and are involved in all biochemical cellular processes, fulfilling specific functions with unmatched precision. This unique specificity makes proteins an ideal scaffold to generate tools for the exploration of natural systems or for the construction of modern therapeutics. Thus, the chemoselective modification of proteins with functionalities that are not defined by the genetic code has become an indispensable approach for life science research and the development of therapeutics. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.04.017DOI Listing

Recent advances on the structure and function of NDH-1: The complex I of oxygenic photosynthesis.

Biochim Biophys Acta Bioenerg 2020 Jul 6:148254. Epub 2020 Jul 6.

Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Molecular Biophysics and Integrative Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. Electronic address:

Photosynthetic NADH dehydrogenase-like complex type-1 (a.k.a, NDH, NDH-1, or NDH-1 L) is a multi-subunit, membrane-bound oxidoreductase related to the respiratory complex I. Read More

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http://dx.doi.org/10.1016/j.bbabio.2020.148254DOI Listing

Machine learning for precision dermatology: Advances, opportunities, and outlook.

J Am Acad Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Division of Dermatology, Department of Medicine, UCLA, Los Angeles, CA 90095, United States.

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http://dx.doi.org/10.1016/j.jaad.2020.06.1019DOI Listing

Novel advances in biotransformation and bioactivation research-2019 year in review.

Drug Metab Rev 2020 Jul 9:1-33. Epub 2020 Jul 9.

Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.

Biotransformation is one of the main mechanisms used by the body to eliminate drugs. As drug molecules become more complicated, the involvement of drug metabolizing enzymes increases beyond those that are typically studied, such as the cytochrome P450 enzymes. In this review, we try to capture the many outstanding articles that were published in the past year in the field of biotransformation (see Table 1). Read More

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http://dx.doi.org/10.1080/03602532.2020.1772281DOI Listing

Cancer immunoediting and immune dysregulation in multiple myeloma.

Blood 2020 Jul 9. Epub 2020 Jul 9.

INSERM, Toulouse, France.

Avoiding immune destruction is a hallmark of cancer. Over the past few years, significant advances have been made in understanding immune dysfunction and immunosuppression in multiple myeloma (MM), and various immunotherapeutic approaches have delivered improved clinical responses. However, it is still challenging to completely eliminate malignant plasma cells (PCs) and achieve complete cure. Read More

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http://dx.doi.org/10.1182/blood.2020006540DOI Listing

Keeping the power on to home medical devices.

PLoS One 2020 9;15(7):e0235068. Epub 2020 Jul 9.

Centre for Energy Data Innovation, University of Queensland, Brisbane, QLD, Australia.

Advances in digital health technologies have revolutionised home medical care. Yet many home medical devices (HMEDs, which includes devices referred to as 'life support equipment') rely upon a stable and resilient electricity supply. For users of HMEDs, interruptions to electricity supply can compromise treatment, well-being or survival. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235068PLOS

Control of vessel diameters mediated by flow-induced outward vascular remodeling in vitro.

Biofabrication 2020 Jul 9;12(4):045008. Epub 2020 Jul 9.

Department of System Design Engineering, Keio University, Yokohama 223-8522, Japan.

Vascular networks consist of hierarchical structures of various diameters and are necessary for efficient blood distribution. Recent advances in vascular tissue engineering and bioprinting have allowed us to construct large vessels, such as arteries, small vessels, such as capillaries and microvessels, and intermediate-scale vessels, such as arterioles, individually. However, little is known about the control of vessel diameters between small vessels and intermediate-scale vessels. Read More

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http://dx.doi.org/10.1088/1758-5090/ab9316DOI Listing

Advances in Telemedicine in Ophthalmology.

Semin Ophthalmol 2020 Jul 9:1-6. Epub 2020 Jul 9.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School , Boston, MA, USA.

Telemedicine is the provision of healthcare-related services from a distance and is poised to move healthcare from the physician's office back into the patient's home. The field of ophthalmology is often at the forefront of technological advances in medicine including telemedicine and the use of artificial intelligence. Multiple studies have demonstrated the reliability of tele-ophthalmology for use in screening and diagnostics and have demonstrated benefits to patients, physicians, as well as payors. Read More

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http://dx.doi.org/10.1080/08820538.2020.1789675DOI Listing

The lecture-free curriculum: Setting the stage for life-long learning: AMEE Guide No. 135.

Med Teach 2020 Jul 9:1-8. Epub 2020 Jul 9.

Faculty Development Unit, Education Development Center, Tehran University of Medical Sciences, Tehran, Iran.

In this AMEE Guide we propose that instruction in health sciences education transform to 'lecture-free.' We present rationale for this proposal, guidance on approaches and strategies to achieve the goal, likely challenges, and what we consider the value-added outcomes. We are supported by a confluence of factors: advances in the science of learning the learning of science and clinical reasoning, incontrovertible evidence that active and engaged learning strategies have better outcomes, current and emerging technology infrastructure in and out of the classroom, and best-practice instructional design. Read More

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http://dx.doi.org/10.1080/0142159X.2020.1789083DOI Listing

Virtual monoenergetic images preserve diagnostic assessability in contrast media reduced abdominal spectral detector CT.

Br J Radiol 2020 Jul 8:20200340. Epub 2020 Jul 8.

Institute for Diagnostic and Interventional Radiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Objectives: To investigate if low-keV virtual monoenergetic images (VMI) from abdominal spectral detector CT (SDCT)with reducedintravenous contrast media (RCM) provide abdominal assessment similar to conventionalimages with standard contrast media dose (SCM).

Methods: 78 patients with abdominal SDCT were retrospectively included: 41 patients at risk for adverse reactions who received 44 RCM examinations with 50 ml and 37 patients who underwent 44 SCM examinations with 100 ml of contrast media and who were matched for effective body diameters. RCM, SCM images and RCM-VMI were reconstructed. Read More

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http://dx.doi.org/10.1259/bjr.20200340DOI Listing

Collaborative, Multidisciplinary Evaluation of Cancer Variants Through Virtual Molecular Tumor Boards Informs Local Clinical Practices.

JCO Clin Cancer Inform 2020 Jul;4:602-613

Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC.

Purpose: The cancer research community is constantly evolving to better understand tumor biology, disease etiology, risk stratification, and pathways to novel treatments. Yet the clinical cancer genomics field has been hindered by redundant efforts to meaningfully collect and interpret disparate data types from multiple high-throughput modalities and integrate into clinical care processes. Bespoke data models, knowledgebases, and one-off customized resources for data analysis often lack adequate governance and quality control needed for these resources to be clinical grade. Read More

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http://dx.doi.org/10.1200/CCI.19.00169DOI Listing

Imaging of Monoamine Neurotransmitters with Fluorescent Nanoscale Sensors.

Chempluschem 2020 Jul;85(7):1465-1480

Institute of Physical Chemistry, Göttingen University, Tammannstrasse 2, 37077, Göttingen, Germany.

Cells use biomolecules to convey information. For instance, neurons communicate by releasing chemicals called neurotransmitters, including several monoamines. The information transmitted by neurons is, in part, coded in the type and amount of neurotransmitter released, the spatial distribution of release sites, the frequency of release events, and the diffusion range of the neurotransmitter. Read More

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http://dx.doi.org/10.1002/cplu.202000248DOI Listing

The astrocytic-neuronal crosstalk gets jammed: alternative perspectives on the onset of neuropsychiatric disorders.

Eur J Neurosci 2020 Jul 9. Epub 2020 Jul 9.

Department of Psychiatry and Psychotherapy, University of Regensburg, 93053, Regensburg, Germany.

Investigating interactions of glia cells and synapses during development and in adulthood is the focus of several research programmes which aim at understanding the neurobiology of brain physiological and pathological processes. Both glia-specific released and membrane-bound proteins play essential roles in the development, maintenance and functionality of synaptic connections. Alterations in synaptic contacts in specific brain areas are hallmarks of several brain diseases, such as major depressive disorder, autism spectrum disorder and schizophrenia. Read More

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http://dx.doi.org/10.1111/ejn.14900DOI Listing

Designer Metal-Organic Frameworks for Size-Exclusion-Based Hydrocarbon Separations: Progress and Challenges.

Adv Mater 2020 Jul 9:e2002603. Epub 2020 Jul 9.

Hoffmann Institute of Advanced Materials, Shenzhen Polytechnic, 7098 Liuxian Boulevard, Shenzhen, Guangdong, 518055, China.

The separation of hydrocarbons is of primary importance in the petrochemical industry but remains a challenging process. Hydrocarbon separations have traditionally relied predominantly on costly and energy-intensive heat-driven procedures such as low-temperature distillations. Adsorptive separation based on porous solids represents an alternative technology that is potentially more energy efficient for the separation of some hydrocarbons. Read More

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http://dx.doi.org/10.1002/adma.202002603DOI Listing

Functional annotation of genomic variation: DNA methylation episignatures in neurodevelopmental Mendelian disorders.

Hum Mol Genet 2020 Jul 9. Epub 2020 Jul 9.

Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, ON N6A5W9, Canada.

The breadth and complexity of genetic testing in patients with suspected Mendelian neurodevelopmental disorders has rapidly expanded in the past two decades. However, in spite of advances in genomic technologies, genetic diagnosis remains elusive in more than half of these patients. Epigenomics, and in particular genomic DNA methylation profiles, are now known to be associated with the underpinning genetic defects in a growing number of Mendelian disorders. Read More

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http://dx.doi.org/10.1093/hmg/ddaa144DOI Listing

Nanocomposite hydrogels for tissue engineering applications.

Nanoscale 2020 Jul 9. Epub 2020 Jul 9.

CAS Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.

Tissue engineering is an important field of regenerative medicine, which combines scaffolds and cell transplantation to develop substitute tissues and/or promote tissue regeneration. Hydrogels, a three-dimensional network with high water content and biocompatibility, have been widely used as scaffolds to mimic the structure and properties of tissues. However, the low mechanical strength and limited functions of traditional hydrogels greatly limited their applications in tissue engineering. Read More

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http://dx.doi.org/10.1039/d0nr03785kDOI Listing

Perspective on theoretical methods and modeling relating to electro-catalysis processes.

Chem Commun (Camb) 2020 Jul 9. Epub 2020 Jul 9.

School of Physics, Southeast University, Nanjing 211189, China.

Electro-catalysis is expected to be a promising clean alternative for energy conversion, and the search for effective and stable electro-catalysts is fundamental. Theoretical calculations play an important role in the rational design and optimization of the performance of electro-catalysts by revealing active sites for reactions and corresponding reaction mechanisms. However, the simulation of electrochemical processes under realistic conditions, for instance, electrode-electrolyte interface structures and the dynamic movement of species around the interface, is still limited. Read More

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http://dx.doi.org/10.1039/d0cc02998jDOI Listing

Luminescent lanthanide metal-organic framework nanoprobes: from fundamentals to bioapplications.

Nanoscale 2020 Jul 9. Epub 2020 Jul 9.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, State Key Laboratory of Structural Chemistry, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China. and Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou, Fujian 350108, China.

Metal-organic frameworks (MOFs), a unique type of porous material characterized by high porosity, large internal surface area and remarkable structural tunability, have emerged as very attractive functional materials for a variety of applications. As a promising subclass of MOFs, lanthanide metal-organic frameworks (Ln-MOFs) integrate the unique advantages of MOFs and the intrinsic features of lanthanide ions, such as sharp emission bands, long luminescent lifetimes, large Stokes shifts, high color purity and high resistance to photobleaching. In this minireview, we provide a brief overview of the most recent advances in luminescent Ln-MOF nanoprobes, which covers from their chemical and physical fundamentals to bioapplications, including their synthetic strategies, optical properties and promising bioapplications in biodetection, bioimaging and therapy. Read More

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http://dx.doi.org/10.1039/d0nr03373aDOI Listing

AI on a chip.

Lab Chip 2020 Jul 9. Epub 2020 Jul 9.

Department of Chemistry, University of Tokyo, Tokyo 113-0033, Japan. and Institute of Technological Sciences, Wuhan University, Hubei 430072, China and Department of Bioengineering, University of California, Los Angeles, California 90095, USA.

Artificial intelligence (AI) has dramatically changed the landscape of science, industry, defence, and medicine in the last several years. Supported by considerably enhanced computational power and cloud storage, the field of AI has shifted from mostly theoretical studies in the discipline of computer science to diverse real-life applications such as drug design, material discovery, speech recognition, self-driving cars, advertising, finance, medical imaging, and astronomical observation, where AI-produced outcomes have been proven to be comparable or even superior to the performance of human experts. In these applications, what is essentially important for the development of AI is the data needed for machine learning. Read More

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http://dx.doi.org/10.1039/d0lc00521eDOI Listing

[Advances in the experimental mechanism of acupuncture in the treatment of Alzheimer's disease based on Wnt/β-catenin pathway].

Zhen Ci Yan Jiu 2020 Jun;45(6):508-2

Hospital Affiliated to Institute of Neurology, Anhui University of Chinese Medcine, Hefei 230061; Institute of Neurology, Anhui University of Chinese Medicine, Hefei 230061.

Alzheimer's disease is a neurodegenerative disease closely related to age, which is characterized by cognitive and memory impairment. Extensive studies have confirmed that Wnt/β-catenin signal pathway is involved in the occurrence and development of Alzheimer's disease. With the characteristics of holistic concept and syndrome differentiation, acupuncture is widely used in clinic. Read More

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http://dx.doi.org/10.13702/j.1000-0607.200016DOI Listing

Ovarian incision enhances folliculogenesis: A rat model.

J Obstet Gynaecol Res 2020 Jul 8. Epub 2020 Jul 8.

Department of Obstetrics and Gynecology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Aim: To determine whether performing incision on the surface of the ovarian cortex in rats advances follicular development.

Methods: Five to seven separate superficial incisions were performed on the surface of right ovaries of 6-7-month-old albino Wistar rats. Daily 40 IU of gonadotropins were administered for 14 days. Read More

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http://dx.doi.org/10.1111/jog.14373DOI Listing

40 years and beyond for the National Society of Genetic Counselors: Reflections on genetic counseling practice.

J Genet Couns 2020 Jul 8. Epub 2020 Jul 8.

Invitae, San Francisco, CA, USA.

The National Society of Genetic Counselors (NSGC) was established in 1979 and has grown from a small dedicated group of genetic counselors to over 5,000 certified genetic counselors in 2019. During this time period, there have been tremendous advances in the practice of genetic counseling, the availability of genetic testing, and the use of technology. These advances have significantly changed our roles and responsibilities and have contributed to the expansion and diversification of our field in clinical and non-clinical work settings. Read More

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http://dx.doi.org/10.1002/jgc4.1301DOI Listing

COVID-19 Clinical Diagnostics and Testing Technology.

Pharmacotherapy 2020 Jul 8. Epub 2020 Jul 8.

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Given the global nature of the COVID-19 pandemic, the need for disease detection and expanding testing capacity remains a critical priority. This review discusses the technological advances in testing capability and methodology that are currently employed or in development for detecting the novel coronavirus. We describe the current clinical diagnostics and technology, including molecular and serological testing approaches, for SARS-CoV-2 testing as well as address their advantages and limitations. Read More

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http://dx.doi.org/10.1002/phar.2439DOI Listing

Tailoring Polymer Colloids Derived Porous Carbon Spheres Based on Specific Chemical Reactions.

Adv Mater 2020 Jul 9:e2002475. Epub 2020 Jul 9.

Department of Chemistry, University of Tennessee, Knoxville, TN, 37996, USA.

Porous carbon spheres derived from polymer colloids with regular geometry, monodispersed morphology, well-controlled contents and structures play important roles in many areas of application, such as energy storage/conversion, gas adsorption/separation, catalysis, and chemo-photothermal therapy. Suitable polymerization reaction and synthetic strategy are both critical for the obtainment of stable polymer colloids as carbon precursors. Basic polymerization reactions are the cornerstones of synthetic strategies, which directly provides the direct molecular-based design of functionalized polymer/carbon spheres. Read More

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http://dx.doi.org/10.1002/adma.202002475DOI Listing

Robotic Head and Neck Surgery: Beyond TORS.

Curr Oncol Rep 2020 Jul 9;22(9):88. Epub 2020 Jul 9.

Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, Rua Professor Antonio Prudente, 211, São Paulo, 01509-900, Brazil.

Purpose Of Review: To explore the advances in robotic head and neck surgery (HNS) beyond TORS.

Recent Findings: Although limited, the current literature corroborates the safety of robotic neck surgery, revealing similar surgical/oncologic outcomes, except longer operative time and superior cosmesis. In most of the remote thyroid approaches, use of robotic-assisted surgery is essential. Read More

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http://dx.doi.org/10.1007/s11912-020-00950-7DOI Listing

A review of CRISPR associated genome engineering: application, advances and future prospects of genome targeting tool for crop improvement.

Biotechnol Lett 2020 Jul 8. Epub 2020 Jul 8.

Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, Prayagraj, (U.P.), 211004, India.

The Cas9 nuclease initiates double-stranded breaks at the target position in DNA, which are repaired by the intracellular restoration pathways to eliminate or insert pieces of DNA. CRISPR-Cas9 is proficient and cost-effective since cutting is guided by a piece of RNA instead of protein. Emphasis on this technology, in contrast with two recognized genome editing platforms (i. Read More

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http://dx.doi.org/10.1007/s10529-020-02950-wDOI Listing

The selective dorsal rhizotomy technique for spasticity in 2020: a review.

Authors:
Rick Abbott

Childs Nerv Syst 2020 Jul 9. Epub 2020 Jul 9.

Albert Einstein College of Medicine, Montefiore Health System, 110 E. 210th St, Bronx, NY, 10467, USA.

This review looks at the advances in the surgical technique, selective dorsal rhizotomy, used for the management of spasticity in children. Read More

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http://dx.doi.org/10.1007/s00381-020-04765-6DOI Listing

Recent advances in optical aptasensor technology for amplification strategies in cancer diagnostics.

Anal Bioanal Chem 2020 Jul 8. Epub 2020 Jul 8.

School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China.

Aptamers are chemically synthetic single-stranded DNA or RNA molecules selected by molecular evolution. They have been widely used as attractive tools in biosensing and bioimaging because they can bind to a large variety of targets with high sensitivity and high affinity and specificity. As recognition elements, aptamers contribute in particular to cancer diagnostics by recognizing different cancer biomarkers, while they can also facilitate ultrasensitive detection by further employing signal amplification elements. Read More

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http://dx.doi.org/10.1007/s00216-020-02774-7DOI Listing

Genetics of human malignant peripheral nerve sheath tumors.

Neurooncol Adv 2020 Jul 28;2(Suppl 1):i50-i61. Epub 2019 Nov 28.

Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts.

Malignant peripheral nerve sheath tumors (MPNSTs) are heterogeneous, highly aggressive tumors with no widely effective treatment other than surgery. Genomic architecture of MPNST is similar to other soft tissue sarcomas, with a relatively modest burden of single nucleotide variants and an elevated frequency of copy-number alterations. Recent advances in genomic studies identified previously unrecognized critical involvement of polycomb repressor complex 2 (PRC2) core components and in transition to malignancy. Read More

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http://dx.doi.org/10.1093/noajnl/vdz049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317054PMC

Soluble protein tyrosine phosphatase receptor type Z (PTPRZ) in cerebrospinal fluid is a potential diagnostic marker for glioma.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa055. Epub 2020 Apr 30.

Preparing Section for New Faculty of Medical Science, Fukushima Medical University, Fukushima, Japan.

Background: High-grade glioma is the most pervasive and lethal of all brain malignancies. Despite advances in imaging technologies, discriminating between gliomas and other brain diseases such as multiple sclerosis (MS) often requires brain biopsy. Several reports show that protein tyrosine phosphatase receptor Z (PTPRZ) is highly expressed in glioblastoma, and we found that a soluble cleaved form of PTPRZ (sPTPRZ) was present in the cerebrospinal fluid (CSF). Read More

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http://dx.doi.org/10.1093/noajnl/vdaa055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260697PMC

NCI-CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors-Histone Mutated Midline Glioma Workshop Proceedings.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa007. Epub 2020 Jan 16.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Histone mutations occur in approximately 4% of different cancer types. In 2012, mutations were found in the gene encoding histone variant H3.3 ( gene) in pediatric diffuse intrinsic pontine gliomas and pediatric hemispheric gliomas. Read More

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http://dx.doi.org/10.1093/noajnl/vdaa007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212875PMC
January 2020

Sexually dimorphic impact of the iron-regulating gene, , on survival in glioblastoma.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa001. Epub 2020 Feb 17.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

Background: The median survival for patients with glioblastoma (GBM), the most common primary malignant brain tumor in adults, has remained approximately 1 year for more than 2 decades. Recent advances in the field have identified GBM as a sexually dimorphic disease. It is less prevalent in females and they have better survival compared to males. Read More

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http://dx.doi.org/10.1093/noajnl/vdaa001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212901PMC
February 2020

Highlights of the inaugural ten - the launch of Neuro-Oncology Advances.

Neurooncol Adv 2019 May-Dec;1(1):vdz016. Epub 2019 Aug 28.

Division of Neurosurgery, University Health Network and MacFeeters-Hamilton Neuro-Oncology Program, Princess Margaret Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/noajnl/vdz016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212904PMC

Modeling heterogeneous tumor growth dynamics and cell-cell interactions at single-cell and cell-population resolution.

Curr Opin Syst Biol 2019 Oct 16;17:24-34. Epub 2019 Sep 16.

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Cancer is a complex, dynamic disease that despite recent advances remains mostly incurable. Inter- and intratumoral heterogeneity are generally considered major drivers of therapy resistance, metastasis, and treatment failure. Recent advances in high-throughput experimentation have produced a wealth of data on tumor heterogeneity and researchers are increasingly turning to mathematical modeling to aid in the interpretation of these complex datasets. Read More

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http://dx.doi.org/10.1016/j.coisb.2019.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343346PMC
October 2019

Exploring medical teachers' and interns' experiences regarding professional ethics.

J Educ Health Promot 2020 28;9:131. Epub 2020 May 28.

Medical Education Development Center, Qom University of Medical Sciences, Qom, Iran.

Context: Medical ethics is a practical subject as well as a branch of ethical philosophy and an integral part of the proper practice in medicine. However, the ethics changes in places and over time and is variable. Furthermore, many issues that have occurred as a result of advances in technology add to the complexity of the ethical issues. Read More

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http://dx.doi.org/10.4103/jehp.jehp_706_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325762PMC

Liver Transplant Complications Radiologist Can't Miss.

Cureus 2020 Jun 5;12(6):e8465. Epub 2020 Jun 5.

Radiology, Instituto Nacional De Ciencias Medicas Y Nutricion Salvador Zubiran, Mexico City, MEX.

Liver transplantation is considered the ideal and definitive therapy for patients with end-stage liver disease. Since 1963 advances in liver transplant surgical techniques and immunosuppressive therapies have improved outcomes and patients' survival. However, early diagnosis of graft dysfunction, through different imaging modalities, is crucial for graft survival. Read More

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http://dx.doi.org/10.7759/cureus.8465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336585PMC

Neoadjuvant therapy and immunotherapy strategies for hepatocellular carcinoma.

Am J Cancer Res 2020 1;10(6):1658-1667. Epub 2020 Jun 1.

Department of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Peking Union Medical College Hospital Beijing, China.

Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality rate worldwide. Due to aggressive and invasive characteristics of HCC, poor prognosis is often displayed at advanced stages while therapeutic options are limited. Liver resection is still an essential curative-intent treatment in HCC management, while locoregional and systematic therapies made promising advances that may improve the proportion and outcomes of patients who are surgical candidates. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339264PMC

Noninvasive biomarkers for lung cancer diagnosis, where do we stand?

J Thorac Dis 2020 Jun;12(6):3317-3330

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

The 2010's saw demonstration of the power of lung cancer screening to reduce mortality. However, with implementation of lung cancer screening comes the challenge of diagnosing millions of lung nodules every year. When compared to other cancers with widespread screening strategies (breast, colorectal, cervical, prostate, and skin), obtaining a lung nodule tissue biopsy to confirm a positive screening test remains associated with higher morbidity and cost. Read More

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http://dx.doi.org/10.21037/jtd-2019-ndt-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330751PMC

Do we need to see to believe?-radiomics for lung nodule classification and lung cancer risk stratification.

J Thorac Dis 2020 Jun;12(6):3303-3316

Divison of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

Despite multiple recent advances, the diagnosis and management of lung cancer remain challenging and it continues to be the deadliest malignancy. In 2011, the National Lung Screening Trial (NLST) reported 20% reduction in lung cancer related mortality using annual low dose chest computed tomography (CT). These results led to the approval and nationwide establishment of lung cancer CT-based lung cancer screening programs. Read More

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http://dx.doi.org/10.21037/jtd.2020.03.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330769PMC