Adv Anat Pathol 2022 Mar 7. Epub 2022 Mar 7.
Departments of Pathology Otorhinolaryngology, Faculty of Medicine in Plzen, Charles University Molecular and Genetic Laboratory, Bioptic Laboratory Ltd, Plzen, Czech Republic Institute of Biomedicine, Pathology, University of Turku and Department of Pathology, Turku University Hospital, Turku, Finland Epigenetics and Human Disease Laboratory, Department of Biomedical Sciences and Medicine, Algarve Biomedical Center (ABC), University of Algarve, Faro, Portugal Department of Anatomical Pathology, University of Calgary, Calgary, Alberta, Canada Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium Department of Pathology and Medical Biology, University of Groningen, Groningen, The Netherlands International Head and Neck Scientific Group, Padua, Italy.
This review focuses on the heterogenous group of clear cell neoplasms of salivary glands and attempts to identify major differential diagnostic features. Within the head and neck region, clear cells are found most commonly in salivary gland tumors, but may also be seen in tumors of squamous or odontogenic epithelial origin, primary or metastatic carcinomas, benign or malignant melanocytic lesions, or benign or malignant mesenchymal tumors. Clear cells occur fairly commonly among a wide variety of salivary gland neoplasms, but mostly they constitute only a minor component of the tumor cell population. Read More