34,074 results match your criteria Advancement Flaps


Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Cytometry A 2018 Dec;93(12):1213-1219

Faculty of the Heinrich-Heine, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, University Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany.

Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. Read More

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December 2018
1 Read

DEPArray™ system: An automatic image-based sorter for isolation of pure circulating tumor cells.

Cytometry A 2018 Dec;93(12):1260-1266

Menarini Silicon Biosystems S.p.A, Bologna, Italy.

Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single-cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Read More

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December 2018
1 Read

CytoML for cross-platform cytometry data sharing.

Cytometry A 2018 Dec;93(12):1189-1196

Program in Biostatistics Bioinformatics and Epidemiology, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Western Australia.

CytoML is an R/Bioconductor package that enables cross-platform import, export, and sharing of gated cytometry data. It currently supports Cytobank, FlowJo, Diva, and R, allowing users to import gated cytometry data from commercial platforms into R. Once data are available in R, the data can be further manipulated. Read More

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December 2018
1 Read

Centrifugation affects the purity of liquid biopsy-based tumor biomarkers.

Cytometry A 2018 Dec;93(12):1207-1212

Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Clinical Chemistry, Amsterdam, the Netherlands.

Biomarkers in the blood of cancer patients include circulating tumor cells (CTCs), tumor-educated platelets (TEPs), tumor-derived extracellular vesicles (tdEVs), EV-associated miRNA (EV-miRNA), and circulating cell-free DNA (ccfDNA). Because the size and density of biomarkers differ, blood is centrifuged to isolate or concentrate the biomarker of interest. Here, we applied a model to estimate the effect of centrifugation on the purity of a biomarker according to published protocols. Read More

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December 2018
2 Reads

Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address:

Aims: Idiopathic nature of male infertility disorder needs to be investigated by different horizons of molecular biology for its treatment and to device male contraceptive. Further, it can also aid in advancement of assisted reproductive technology (ART), as nowadays the failure and disquiets of ART are consistent. Herein, we have attempted to find out proteins responsible for male infertility by comparing proteome profile of sperms collected from normal control and asthenozoospermic (AS) males. Read More

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December 2018

Individual and sexual network predictors of HIV incidence among men who have sex with men in Nigeria.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: To date, HIV incidence studies among men who have sex with men (MSM) across sub-Saharan Africa have focused on studying sexual risk practices with less focus on sexual networks.

Setting: TRUST/RV368 conducted in Abuja and Lagos, Nigeria recruited MSM using respondent driven sampling (RDS) and followed HIV negative men for incident infection over 4 years.

Methods: Four-hundred forty-one HIV-uninfected MSM underwent a parallel rapid HIV testing algorithm every 3 months for up to 18 months. Read More

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December 2018

Comparison of Distraction Osteogenesis and Single-Stage Remodeling for Correction of Unilateral Coronal Craniosynostosis.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Plastic and Reconstructive Surgery, Dalhousie University, Halifax.

Background: Unilateral coronal craniosynostosis is a challenging condition in craniofacial surgery. Frontoorbital advancement by single-stage resorbable remodeling and distraction osteogenesis (DO) techniques have known intraoperative differences, but their comparative outcomes are less well characterized.

Methods: A systematic literature search of the MEDLINE, EMBASE, LILACS, and Web of Science databases was conducted. Read More

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December 2018

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties.

MAbs 2018 Dec 14. Epub 2018 Dec 14.

a Genentech, Inc ., South San Francisco , CA , USA.

Bispecific antibody production using single host cells has been a new advancement in the antibody engineering field. We previously showed comparable in vitro biological activity and in vivo mouse pharmacokinetics (PK) for two novel single cell variants (v10 and v11) and one traditional dual cell in vitro-assembled anti-human epidermal growth factor receptor 2/CD3 T-cell dependent bispecific (TDB) antibodies. Here, we extended our previous work to assess single cell-produced bispecific variants of a novel TDB against FcRH5, a B-cell lineage marker expressed on multiple myeloma (MM) tumor cells. Read More

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December 2018

Higher well-being is related to reduced affective reactivity to positive events in daily life.

Emotion 2018 Dec 13. Epub 2018 Dec 13.

Institute of Psychology, Humboldt-Universität zu Berlin.

Within the study of emotions, researchers have increasingly stressed the importance of studying individual differences in emotion dynamics and emotional responding and the way these relate to more stable differences in well-being. However, there is no clear picture regarding affective reactivity to positive events and how different emotional reactions relate to differences in well-being, particularly higher levels of well-being. Theoretical work and empirical findings from different lines of research (e. Read More

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December 2018

Ultra-High Evaporative Heat Fluxes in Nano-Confined Geometries.

Langmuir 2018 Dec 14. Epub 2018 Dec 14.

Advancement in high-performance photonics/electronics devices has amplified generated thermal energy making thermal management a bottleneck for the accelerated innovation in these disciplines. While various methods have been used to tackle the thermal management problem, evaporation with nanometer fluid thickness is one of the most promising approaches for future technological demands. Here, we studied thin-film evaporation in nanochannels under absolute negative pressure in both transient and steady-state conditions. Read More

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December 2018

An integrated enrichment system to facilitate isolation and molecular characterization of single cancer cells from whole blood.

Cytometry A 2018 Dec;93(12):1226-1233

Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Circulating tumor cells (CTCs) carry valuable biological information. While enumeration of CTCs in peripheral blood is an FDA-approved prognostic indicator of survival in metastatic prostate and other cancers, analysis of CTC phenotypic and genomic markers is needed to identify cancer origin and elucidate pathways that can guide therapeutic selection for personalized medicine. Given the emergence of single-cell mRNA sequencing technologies, a method is needed to isolate CTCs with high sensitivity and specificity as well as compatibility with downstream genomic analysis. Read More

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December 2018

A Flow Cytometry-Based Assay for High-Throughput Detection and Quantification of Neutrophil Extracellular Traps in Mixed Cell Populations.

Cytometry A 2018 Dec 14. Epub 2018 Dec 14.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Neutrophil extracellular traps (NETs) are web-like structures composed of decondensed chromatin and antimicrobial proteins that are released into the extracellular space during microbial infections. This active cell death program is known as NETosis. To date, florescence microscopy is the widely accepted method for visualization and quantification of NETs. Read More

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December 2018

Reimbursement pricing for new medical devices in Japan: Is the evaluation of innovation appropriate?

Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.

Department of Economics, Hosei University, Tokyo, Japan.

Objectives: In Japan, strong reimbursement pricing control measures for existing medical device products have rendered new medical device reimbursement pricing critical for manufacturers. Few studies have been conducted on this aspect; therefore, this paper (1) clarifies whether evaluation of innovation is appropriate or not and (2), if not, investigates its background.

Methods: In this research, 319 C1/C2 government decisions for new medical devices in the 10 years from April 2008 to March 2018 were analyzed. Read More

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December 2018

Trends in Female Leadership at High-Profile Otolaryngology Journals, 1997-2017.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington.

Objectives: To determine the proportion and relative advancement of women in leadership positions at high-impact otolaryngology journals.

Methods: Nine clinical otolaryngology journals were selected based on high impact factor and subspecialty representation (journal impact factor, 2016: 1.16-2. Read More

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December 2018

Self-Powered Chemical Sensing Driven by Graphene-Based Photovoltaic Heterojunctions with Chemically Tunable Built-In Potentials.

Small 2018 Dec 12:e1804303. Epub 2018 Dec 12.

KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Ultralow power chemical sensing is essential toward realizing the Internet of Things. However, electrically driven sensors must consume power to generate an electrical readout. Here, a different class of self-powered chemical sensing platform based on unconventional photovoltaic heterojunctions consisting of a top graphene (Gr) layer in contact with underlying photoactive semiconductors including bulk silicon and layered transition metal dichalcogenides is proposed. Read More

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December 2018
1 Read

Patient and public involvement in medical performance processes: A systematic review.

Health Expect 2018 Dec 11. Epub 2018 Dec 11.

Collaboration for the Advancement of Medical Education Research and Assessment, Faculty of Medicine and Dentistry, University of Plymouth, Plymouth, UK.

Background: Patient and public involvement (PPI) continues to develop as a central policy agenda in health care. The patient voice is seen as relevant, informative and can drive service improvement. However, critical exploration of PPI's role within monitoring and informing medical performance processes remains limited. Read More

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December 2018

High-energy nutrition in paediatric cardiac critical care patients: a randomized controlled trial.

Nurs Crit Care 2018 Dec 9. Epub 2018 Dec 9.

Nursing Department, Children's Hospital of Fudan University, Shanghai, People's Republic of China.

Background: Previous studies have shown that feeding a high-energy formula (HF) to infants after cardiac surgery increases energy intake, with fewer side effects on cardiopulmonary function. However, impacts on weight gain and gastrointestinal function remain unclear.

Aims And Objectives: To determine the impact of HF compared with standard formula on weight gain and gastrointestinal tolerance in postoperative infants with congenital heart disease. Read More

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December 2018

Household food insecurity and coping strategies among pensioners in Jimma Town, South West Ethiopia.

BMC Public Health 2018 Dec 14;18(1):1373. Epub 2018 Dec 14.

Department of Health, Behaviour and Society, Jimma University, Jimma, Ethiopia.

Background: Ethiopia is currently facing new challenges related to food insecurity among the urban poor. Pensioners are segments of the population with reduced income and working capacity because of advancement of age and other related problems. There is no empirical evidence on Jimma Town pensioner's household food insecurity and coping strategies. Read More

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December 2018

E-waste: A Challenge for Sustainable Development.

J Health Pollut 2015 Dec 21;5(9):3-11. Epub 2015 Dec 21.

Department of Management and Engineering- Environmental Technology and Management, Linköping University, Linköping, Sweden.

Background: E-waste has been identified as the fastest growing waste stream in the world at present. Rapid socio-economic development and technological advancement are the main drivers of this trend. The hazardous chemical components of e-waste have potential adverse impacts on ecosystems and human health if not managed properly. Read More

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December 2015

Inhibitory Control and Information Processing in ADHD: Comparing the Dual Task and Performance Adjustment Hypotheses.

J Abnorm Child Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Center for Advancement of Youth, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.

Inhibition is a key neurocognitive domain in ADHD that is commonly assessed with the stop-signal task. The stop-signal involves both "go" and "stop" trials; previous research indicates that response times are reliably slower to "go" trials during tasks with vs. without intermittent "stop" trials. Read More

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December 2018
1 Read

Perfluorophenyl Derivatives as Unsymmetrical Linkers for Solid Phase Conjugation.

Front Chem 2018 28;6:589. Epub 2018 Nov 28.

School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.

Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two different series of fluorinated linkers were introduced to the backbone of a model peptide using solid phase peptide synthesis. These fluorinated linkers have the potential to conjugate two asymmetrical groups. Read More

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November 2018

A public health framework for the regulation of marketing.

J Public Health Policy 2018 Dec 13. Epub 2018 Dec 13.

Oregon Research Institute, 1776 Millrace, Eugene, OR, 97403, USA.

Cross-sectional, longitudinal, and experimental studies have found a link between youth exposure to cigarette marketing and youth initiation of smoking. These decisive research findings led to regulations of cigarette marketing to youth-including no television or radio ads, prohibitions on the use of cartoons, bans on transit and billboard advertisements, and disallowing tobacco brand sponsorships of sporting events or concerts. Similar products that may cause more harm than benefits include alcohol, electronic cigarettes, and opioids. Read More

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December 2018

Studies of Radioaerosol Deposition in the Respiratory Tract.

Semin Nucl Med 2019 Jan;49(1):62-70

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.

Deposition of aerosols in the respiratory tract can be quantitatively and qualitatively studied by scintigraphy. The most commonly used radionuclide for this purpose is technetium-99m. The effects of various factors on particle deposition have been investigated by using radiolabeled aerosols in the past decade. Read More

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January 2019
1 Read

Assessing the Role of Artificial Intelligence (AI) in Clinical Oncology: Utility of Machine Learning in Radiotherapy Target Volume Delineation.

Medicines (Basel) 2018 Dec 11;5(4). Epub 2018 Dec 11.

Worcestershire Oncology Centre, Worcestershire Acute Hospitals NHS Trust, Worcester WR5 1DD, UK.

The fields of radiotherapy and clinical oncology have been rapidly changed by the advances of technology. Improvement in computer processing power and imaging quality heralded precision radiotherapy allowing radiotherapy to be delivered efficiently, safely and effectively for patient benefit. Artificial intelligence (AI) is an emerging field of computer science which uses computer models and algorithms to replicate human-like intelligence and perform specific tasks which offers a huge potential to healthcare. Read More

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December 2018
5 Reads

Recent Advances in AIV Biosensors Composed of Nanobio Hybrid Material.

Micromachines (Basel) 2018 Dec 9;9(12). Epub 2018 Dec 9.

School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea.

Since the beginning of the 2000s, globalization has accelerated because of the development of transportation systems that allow for human and material exchanges throughout the world. However, this globalization has brought with it the rise of various pathogenic viral agents, such as Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), Zika virus, and Dengue virus. In particular, avian influenza virus (AIV) is highly infectious and causes economic, health, ethnical, and social problems to human beings, which has necessitated the development of an ultrasensitive and selective rapid-detection system of AIV. Read More

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December 2018
1 Read

Experimental Phantom-Based Security Analysis for Next-Generation Leadless Cardiac Pacemakers.

Sensors (Basel) 2018 Dec 7;18(12). Epub 2018 Dec 7.

iTEAM, Universitat Politècnica de València, 46022 Valencia, Spain.

With technological advancement, implanted medical devices can treat a wide range of chronic diseases such as cardiac arrhythmia, deafness, diabetes, etc. Cardiac pacemakers are used to maintain normal heart rhythms. The next generation of these pacemakers is expected to be completely wireless, providing new security threats. Read More

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December 2018

The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.

Animal models play important roles in investigating the pathobiology of cancer, identifying relevant pathways, and developing novel therapeutic tools. Despite rapid progress in the understanding of disease mechanisms and technological advancement in drug discovery, negative trial outcomes are the most frequent incidences during a Phase III trial. Skin cancer is a potential life-threatening disease in humans and might be medically futile when tumors metastasize. Read More

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December 2018

Update on prevention of cytomegalovirus in hematopoietic cell transplantation.

Authors:
Sanjeet S Dadwal

Curr Opin Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Division of Infectious Disease, City of Hope National Medical Center, Duarte, California, USA.

Purpose Of Review: Cytomegalovirus infection (CMVi) has been the troll of allogeneic hematopoietic cell transplantation (allo-HCT). Over the last 4 decades various approaches have been adopted to minimize the burden from CMVi. There has been major advancement in the management of CMVi in HCT within the last few years that is poised to change the approaches employed in preventing and managing CMVi. Read More

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December 2018

The ability of the ICD-AIS map to identify seriously injured patients in road traffic accidents-A study from Finland.

Traffic Inj Prev 2018 Dec 13:1-6. Epub 2018 Dec 13.

d Department of Orthopaedics and Traumatology , North Kymi Hospital , Kouvola , Finland.

Objective: In Finland, the severity of road traffic injuries is determined using the International Classification of Diseases, 10th Revision, Finnish Modification (ICD-10-FM) injury codes from Finnish Hospital Discharge data and the automatic conversion tool (ICD-AIS map) developed by the Association for the Advancement of Automotive Medicine (AAAM). The aim of this study was to evaluate the ability of the ICD-AIS map to identify seriously injured patients due to traffic accidents in Finnish injury data by comparing the severity rating generated by an expert and by the ICD-AIS map.

Methods: Our data came from the North Kymi Hospital (level 2 trauma center at the time of the study). Read More

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December 2018

Transition-metal-catalyzed site-selective C7-functionalization of indoles: advancement and future prospects.

Chem Commun (Camb) 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.

C7-Decorated indoles are important structural motifs present in a plethora of bioactive and pharmaceutical compounds. Early stage developments for C7 modifications were realized through directed metallation (DOM) and subsequent quenching with suitable electrophiles or by halogenation with Cu(ii) halides. Direct C-7 functionalization of indoles is comparatively difficult compared to functionalization at C-2 and C-3 positions owing to the inherent reactivity of the pyrrole-type ring. Read More

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December 2018

Recent Advancement against Neglected Diseases.

Curr Top Med Chem 2018 ;18(18):1520-1521

Department of Biochemistry/Bioinformatics Institute of Science GITAM University, Visakhapatnam, A.P, India.

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January 2018

Development of an Enzyme-Linked Immunosorbent Assay for the Detection of GM Proteins in Transgenic Crops/Produce.

Methods Mol Biol 2019 ;1902:159-166

Faculty of Science, Molecular Biology and Immunology Lab, School of Biotechnology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Enzyme-linked immunosorbent assays are always being used extensively for the identification of genetically modified protein in transgenic crops/produce. With the advancement in the detection strategies, competitive and sandwich immunoassays are more convenient and sensitive for the GM protein detection and its quantification in transgenic crops. This chapter is focusing on the competitive ELISA including sandwich ELISA for the detection of the GM proteins. Read More

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January 2019

Effects of Hat-Shaped Mortised Genioplasty with Genioglossus Muscle Advancement on Retrogenia and Snoring: Assessment of Esthetic, Functional, and Psychosocial Results.

Aesthetic Plast Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea.

Background: An increasing number of patients undergo genioplasty for esthetic purposes to correct micrognathism or retrognathism. However, these conditions are considered an important risk factor for snoring. The purpose of this study was to evaluate both esthetic improvement and functional changes of snoring symptoms in patients who underwent hat-shaped mortised advancing genioplasty with genioglossus muscle advancement. Read More

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December 2018

Physician mothers' experience of workplace discrimination: a qualitative analysis.

BMJ 2018 Dec 12;363:k4926. Epub 2018 Dec 12.

Program for Clinical Research, Department of Dermatology, University of California, San Francisco, San Francisco, California, USA

Objectives: To report woman physicians' experiences, in their own words, of discrimination based on their role as a mother.

Design: Qualitative analysis of physician mothers' free-text responses to the open question: "We want to hear your story and experience. Please share" included in questions about workplace discrimination. Read More

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December 2018

Transitioning to academia: Exploring the experience of new family medicine faculty members at the beginning of their academic careers.

Can Fam Physician 2018 Dec;64(12):907-913

Professor and Chair of the master of clinical science and doctoral programs in the Centre for Studies in Family Medicine in the Department of Family Medicine at the Schulich School of Medicine and Dentistry at Western University in London, Ont, and Professor in the School of Social Work at King's University College in London.

Objective: To explore the experience of new family medicine faculty members at the beginning of their academic careers and determine what factors might facilitate their transition to an academic role in family medicine.

Design: Qualitative, phenomenologic study of new academic family physicians.

Setting: Eight Canadian departments of family medicine. Read More

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December 2018

Artificial Intelligence for infectious disease Big Data Analytics.

Infect Dis Health 2018 Nov 1. Epub 2018 Nov 1.

Department of Systems Engineering and Engineering Management, City University of Hong Kong, Hong Kong, China.

Background: Since the beginning of the 21st century, the amount of data obtained from public health surveillance has increased dramatically due to the advancement of information and communications technology and the data collection systems now in place.

Methods: This paper aims to highlight the opportunities gained through the use of Artificial Intelligence (AI) methods to enable reliable disease-oriented monitoring and projection in this information age.

Results And Conclusion: It is foreseeable that together with reliable data management platforms AI methods will enable analysis of massive infectious disease and surveillance data effectively to support government agencies, healthcare service providers, and medical professionals to response to disease in the future. Read More

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November 2018

Ocular ultrasound versus MRI in the detection of extrascleral extension in a patient with choroidal melanoma.

BMC Ophthalmol 2018 Dec 12;18(1):320. Epub 2018 Dec 12.

Department of Ophthalmology, University of Utah, Salt Lake City, UT, USA.

Background: To describe the superiority of ocular ultrasound in the diagnostic management of extrascleral extension in choroidal melanoma.

Case Presentation: We present a case of a 94-year-old male with choroidal melanoma of the right eye imaged with MRI and ocular ultrasound to aid in the detection of extrascleral extension.

Conclusions: With advancement in technology and new imaging modalities emerging, it can become difficult to determine the best diagnostic approach for patients. Read More

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December 2018

Ten myths (or facts?) about workaholism: An appetitive motivation framework.

Authors:
Steve Sussman

J Behav Addict 2018 Dec 13:1-4. Epub 2018 Dec 13.

1 Preventive Medicine, Psychology, and Social Work, Institute for Health Promotion and Disease Prevention Research, University of Southern California , Los Angeles, CA, USA.

This commentary intends to provide constructive input into the "Ten myths about work addiction" by Griiffiths et al. (2018). I place the information into an appetitive motivation theoretical lens of addiction as well as outline the kernels of truth associated with each myth. Read More

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December 2018

3D Printing-Encompassing the Facets of Dentistry.

Front Bioeng Biotechnol 2018 22;6:172. Epub 2018 Nov 22.

Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

This narrative review presents an overview on the currently available 3D printing technologies and their utilization in experimental, clinical and educational facets, from the perspective of different specialties of dentistry, including oral and maxillofacial surgery, orthodontics, endodontics, prosthodontics, and periodontics. It covers research and innovation, treatment modalities, education and training, employing the rapidly developing 3D printing process. Research-oriented advancement in 3D printing in dentistry is witnessed by the rising number of publications on this topic. Read More

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November 2018

Micro-channel sieve electrode for concurrent bidirectional peripheral nerve interface. Part A: Recording.

J Neural Eng 2018 Nov 9. Epub 2018 Nov 9.

Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Drive, Saint Louis, Missouri, 63130-4899, UNITED STATES.

Objective: Advancement in prosthetic limb technology requires corresponding improvements in the capability of the amputee to naturally control the device via original motor pathways while simultaneously receiving haptic feedback via sensory pathways. Recording efferent axonal activity using a peripheral neural interface (PNI) allows a good tradeoff between invasiveness and selectivity while possibly preserving the phenomenology of controlling the original limb. One such PNI, the thin-film transverse intrafascicular multichannel electrode (tfTIME), has been shown to be successful in controlling powered prosthetics. Read More

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November 2018

Improving Quality, Reproducibility, and Usability of FRET-Based Tension Sensors.

Cytometry A 2018 Dec 6. Epub 2018 Dec 6.

Department of Biomedical Engineering, Duke University, Durham, North Carolina, 27708.

Mechanobiology, the study of how mechanical forces affect cellular behavior, is an emerging field of study that has garnered broad and significant interest. Researchers are currently seeking to better understand how mechanical signals are transmitted, detected, and integrated at a subcellular level. One tool for addressing these questions is a Förster resonance energy transfer (FRET)-based tension sensor, which enables the measurement of molecular-scale forces across proteins based on changes in emitted light. Read More

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December 2018

Best Practices for Preparing a Single Cell Suspension from Solid Tissues for Flow Cytometry.

Cytometry A 2018 Dec 6. Epub 2018 Dec 6.

Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio.

Preparing a single cell suspension is a critical step in any solid tissue flow cytometry experiment. Tissue dissection, enzymatic digestion, and mechanical dissociation are three significant steps leading to the degradation of the extracellular matrix and the isolation of single cells, allowing the generation of high-quality flow cytometry data. Cells and the extracellular matrix contain various proteins and other structures which must be considered when designing a tissue digestion protocol to preserve the viability of cells and the presence of relevant antigens while digesting matrix components and cleaving cell-cell junctions. Read More

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December 2018

OVO homologue-like 1 promotes osteoblast differentiation through BMP2 expression.

J Cell Physiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Biotechnology, College of Engineering, Daegu University, Daegu, Korea.

OVO homologue-like 1 (OVOL1) encodes a C2H2 zinc finger protein and is an evolutionarily conserved gene in mammals. The OVOL1 expression is required for development. However, the function of OVOL1 in bone metabolism remains unreported. Read More

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December 2018

National survey: current prevalence and characteristics of home mechanical ventilation in Hungary.

BMC Pulm Med 2018 Dec 6;18(1):190. Epub 2018 Dec 6.

Department of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78B, Budapest, Hungary.

Background: Home mechanical ventilation is an established treatment for chronic respiratory failure resulting in improved survival and quality of life. Technological advancement, evolving health care reimbursement systems and newly implemented national guidelines result in increased utilization worldwide. Prevalence shows great geographical variations and data on East-Central European practice has been scarce to date. Read More

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December 2018
2 Reads

Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations.

PLoS One 2018 12;13(12):e0206579. Epub 2018 Dec 12.

Institute of Statistics, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.

Multistage tumorigenesis is a dynamic process characterized by the accumulation of mutations. Thus, a tumor mass is composed of genetically divergent cell subclones. With the advancement of next-generation sequencing (NGS), mathematical models have been recently developed to decompose tumor subclonal architecture from a collective genome sequencing data. Read More

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December 2018

Delayed graft function in kidney transplantation.

Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.

Transplant Nephrology, Keck Hospital of USC, California, USA.

Purpose Of Review: Delayed graft function (DGF) has several long-term graft implications in the field of kidney transplantation and remains a challenge. The incidence of DGF is on the rise because of an increasing use of marginal kidneys in an era of organ shortage. Risk factors for DGF are numerous and stem from multiple sources in the transplant chain starting from the donor to its final allocation in the recipient. Read More

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December 2018
1 Read

Surgical Algorithmic Approach to Facilitate Primary Closure of the Anterolateral Thigh Flap Donor Site in Head and Neck Reconstruction.

Ann Plast Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Plastic and Reconstructive Surgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan.

Background: Use of the anterolateral thigh (ALT) flap has gained popularity in head and neck reconstruction. However, donor sites that cannot achieve primary closure are reported to have poorer functional and aesthetic outcomes. Therefore, we propose an algorithm to facilitate primary closure of the donor site. Read More

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December 2018
1 Read

[Science and nursing science: What links, what issues and what future development for the discipline of nursing?]

Rech Soins Infirm 2018 09(134):6-15

This article examines the terms science, discipline and knowledge from the perspective of the use and advancement of knowledge in the discipline of nursing. It views the notion of organized knowledge as the foundation of a science as well as considering the use of scientific methods as imperative in any discipline that aims to contribute to the world of ideas by relying on rationality. This paper aims to trace the link between science and nursing science, to clarify scientific issues for nursing, and to begin thinking about understanding the concept of diversity and the effective contribution of doctoral training in nursing as a guarantee of the future evolution of this discipline. Read More

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September 2018

Comparative Analysis of Defects in Mg-Implanted and Mg-Doped GaN Layers on Freestanding GaN Substrates.

Nanoscale Res Lett 2018 Dec 11;13(1):403. Epub 2018 Dec 11.

National Institute for Materials Science, Tsukuba, Ibaraki, 305-0047, Japan.

Inefficient Mg-induced p-type doping has been remained a major obstacle in the development of GaN-based electronic devices for solid-state lighting and power applications. This study reports comparative structural analysis of defects in GaN layers on freestanding GaN substrates where Mg incorporation is carried out via two approaches: ion implantation and epitaxial doping. Scanning transmission electron microscopy revealed the existence of pyramidal and line defects only in Mg-implanted sample whereas Mg-doped sample did not show presence of these defects which suggests that nature of defects depends upon incorporation method. Read More

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December 2018
1 Read

Selective and super-selective C-arm based cone beam CT angiography (CBCTA) with DynaCT for CyberKnife radiosurgery planning of intracranial arteriovenous malformations (AVMs).

J Radiosurg SBRT 2018 ;5(4):305-313

Division of Radiation Oncology, University of Ottawa, Ottawa, ON, Canada.

Background: Successful radiosurgery for intracranial arteriovenous malformations (AVMs) requires accurate delineation of the nidus in 3D. Exact targeting and precise equipment is needed to achieve obliteration of the nidus while minimizing toxicity to the surrounding brain. In some micro-AVMs and poorly visible AVMs we have used cone beam CT angiography (CBCTA) with selective and super-selective angiography where a micro-catheter is advanced into the feeding arteries- to assist with nidus definition for CyberKnife radiosurgery planning. Read More

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January 2018