611,747 results match your criteria Advanced science Weinheim Baden-Wurttemberg Germany[Journal]


Paired Kidney Exchange Transplantation - Pushing the boundaries.

Transpl Int 2020 Jul 7. Epub 2020 Jul 7.

Deptt. Of Nephrology & transplant Medicine, Medanta - The Medicity, Sector 38, Gurgaon, Harayana, India.

The scarcity of living organ donors makes it imperative to develop newer innovations to optimize and maximize the utilization of the available pool. ABO and HLA sensitization are important immunological barriers in renal transplant and can potentially lead to rejection of almost one-third of the willing living donors. Paired kidney exchange (PKE) is a rapidly growing method used to overcome these barriers and has grown in popularity over the last three decades since its introduction in 1986. Read More

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http://dx.doi.org/10.1111/tri.13693DOI Listing

Statewide Interventions and Covid-19 Mortality in the United States: An Observational Study.

Clin Infect Dis 2020 Jul 8. Epub 2020 Jul 8.

Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.

Background: Social distancing is encouraged to mitigate viral spreading during outbreaks. However, the association between distancing and patient-centered outcomes in Covid-19 has not been demonstrated. In the United States social distancing orders are implemented at the state level with variable timing of onset. Read More

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http://dx.doi.org/10.1093/cid/ciaa923DOI Listing

Feasibility, Reliability, and Agreement of Transperineal Ultrasound Measurement: Results from a Longitudinal Cohort Study.

Fetal Diagn Ther 2020 Jul 7:1-10. Epub 2020 Jul 7.

Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong,

Objectives: To evaluate the feasibility, reliability, and agreement of serial transperineal ultrasound (TPU) assessment of fetal head station (parasagittal angle of progression [psAOP], head-perineum distance [HPD], and head-symphysis distance [HSD]) and sonographic cervical dilatation (SCD), compared to fetal head station and cervical dilatation determined by vaginal examination, respectively.

Methods: This was a prospective longitudinal study in singleton pregnancies undergoing induction of labor at term. Paired assessment of fetal head station and cervical dilatation by vaginal examination, with TPU assessment of psAOP, HPD, HSD, and SCD was made serially. Read More

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http://dx.doi.org/10.1159/000507549DOI Listing

Structural correlations in the enhancement of ferroelectric properties of Sr doped BaTiO.

J Phys Condens Matter 2020 Jul 7. Epub 2020 Jul 7.

Dr BR Ambedkar National Institute of Technology, Jalandhar, Punjab, INDIA.

The effect of Sr doping in BaTiO(BTO) with nominal compositions BaSrTiO(BSTO) have been explored on its structural, lattice vibration, dielectric, ferroelectric and electrocaloric properties. The temperature dependent dielectric results elucidate the enhancement in dielectric constant and exhibit three frequency independent transitions around 335, 250 and 185 K which are related to different structural transitions. All these transitions occur at lower temperature as compared with pristine BTO, however; remnant electric polarization (P) of BSTO is much higher than in BTO. Read More

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http://dx.doi.org/10.1088/1361-648X/aba384DOI Listing

Senescence-like phenotype in post-mitotic cells of mice entering middle age.

Aging (Albany NY) 2020 Jul 7;12. Epub 2020 Jul 7.

International Clinical Research Center (FNUSA-ICRC), St' Anne University Hospital, Brno, Czech Republic.

Staining mice tissues for β-galactosidase activity is a fundamental tool to detect age- or disease-associated cellular senescence. However, reported analyses of positivity for senescence-associated β-galactosidase activity or for other markers of senescence in post-mitotic cells of healthy murine tissues have been fragmentary or inconclusive. Here, we attempted to independently deepen this knowledge using multiple senescence markers within the same cells of wild type mice entering middle age (9 months of age). Read More

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http://dx.doi.org/10.18632/aging.103637DOI Listing

Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2020 Jul;18(7):873-898

29National Comprehensive Cancer Network.

Treatment is complex for patients with head and neck (H&N) cancers with specific site of disease, stage, and pathologic findings guiding treatment decision-making. Treatment planning for H&N cancers involves a multidisciplinary team of experts. This article describes supportive care recommendations in the NCCN Guidelines for Head and Neck Cancers, as well as the rationale supporting a new section on imaging recommendations for patients with H&N cancers. Read More

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http://dx.doi.org/10.6004/jnccn.2020.0031DOI Listing

Relationship Between Perceptions of Treatment Goals and Psychological Distress in Patients With Advanced Cancer.

J Natl Compr Canc Netw 2020 Jul;18(7):849-855

1Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center.

Background: Studies have shown gaps in prognostic understanding among patients with cancer. However, few studies have explored patients' perceptions of their treatment goals versus how they perceive their oncologist's goals, and the association of these views with their psychological distress.

Methods: We conducted a cross-sectional study of 559 patients with incurable lung, gastrointestinal, breast, and brain cancers. Read More

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http://dx.doi.org/10.6004/jnccn.2019.7525DOI Listing

Neoadjuvant Immunotherapy-Based Systemic Treatment in MMR-Deficient or MSI-High Rectal Cancer: Case Series.

J Natl Compr Canc Netw 2020 Jul;18(7):798-804

1UC Davis Comprehensive Cancer Center, Sacramento, California.

Treatment options for locally advanced rectal cancer have continued to consist largely of chemotherapy, chemoradiation, and/or surgical resection. For patients who are unable to undergo these therapeutic modalities or who do not to experience a response to them, treatment options are limited. We report 3 cases of mismatch repair-deficient (dMMR) locally advanced adenocarcinoma of the rectum that showed significant response with neoadjuvant immunotherapy-based systemic treatment. Read More

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http://dx.doi.org/10.6004/jnccn.2020.7558DOI Listing

Assessment pedestrian crossing safety using vehicle-pedestrian interaction data through two different approaches: Fixed videography (FV) vs In-Motion Videography (IMV).

Accid Anal Prev 2020 Jul 4;144:105661. Epub 2020 Jul 4.

Department of Civil Engineering, Babol Noshirvani University of Technology, Shariati Ave., PO Box: 4714871167, Babol, Iran. Electronic address:

A significant portion of pedestrian accidents occurs in the outskirts areas due to the high vehicle speed and lack of safety facilities for pedestrians. Behavioral study on drivers and pedestrians is the key to better understand the causes of pedestrian accidents in order to develop safety models. Despite numerous studies on pedestrian safety based on various roads, outskirt areas have not been considered. Read More

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http://dx.doi.org/10.1016/j.aap.2020.105661DOI Listing

On-demand drug release nanoplatform based on fluorinated aza-BODIPY for imaging-guided chemo-phototherapy.

Biomaterials 2020 Jul 1;256:120211. Epub 2020 Jul 1.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing, 211800, China; School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing, 210044, China. Electronic address:

Intelligent drug delivery systems (DDS), integrating with multi-modal imaging guidance and controlled drug release, have practical significance in enhancing the therapeutic efficiency of tumors. Herein, fluorinated aza-boron-dipyrromethene (NBF) with high near-infrared absorption is synthesized by introducing nonadecafluorodecanoic acid into aza-BODIPY via the amide bond. Through the co-precipitation methods, nanoparticles (NPs) based on NBF are fabricated and the obtained NBF NPs can not only load with DOX with a high loading efficiency (25%, DNBF NPs), but also absorb PFC droplets (1H-perfluoropentane) with bp of 42 °C because of the fluorinated chains inside NBF NPs (PDNBF NPs). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120211DOI Listing

Impact of the insect gut microbiota on ecology, evolution, and industry.

Curr Opin Insect Sci 2020 Jun 21;41:33-39. Epub 2020 Jun 21.

Graduate School of Agriculture, Hokkaido University, 060-8589 Sapporo, Japan; Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Hokkaido Center, 062-8517 Sapporo, Japan. Electronic address:

Insects harbor diverse microorganisms in the gut, providing their host with physiological and ecological advantages. For example, gut symbionts contribute to detoxification in phytophagous insects, degradation of lignocellulose in xylophagous insects, and in many insects, protection from pathogens by producing antimicrobial compounds. Furthermore, an unexpected function of the insect gut microbiota has been discovered-plastic degradation. Read More

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http://dx.doi.org/10.1016/j.cois.2020.06.004DOI Listing

Clinical phenotypes, genotypes and treatment in Chinese dystonia patients with KMT2B variants.

Parkinsonism Relat Disord 2020 Jun 9;77:76-82. Epub 2020 Jun 9.

Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, China. Electronic address:

Background: KMT2B-related dystonia is a recently discovered hereditary dystonia that mostly occurs in childhood. This dystonia usually progresses to generalized dystonia with cervical, cranial, pharynx and larynx involvement. Our study summarizes genotype-phenotype features and deep brain stimulation (DBS) efficacy observed with KMT2B-related dystonia patients in China. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2020.06.002DOI Listing

Branching out: what omics can tell us about primate evolution.

Curr Opin Genet Dev 2020 Jul 4;62:65-71. Epub 2020 Jul 4.

Institute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain; Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, 08010, Barcelona, Spain; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Edifici ICTA-ICP, c/ Columnes s/n, 08193 Cerdanyola del Vallès, Barcelona, Spain. Electronic address:

The study of primate comparative genomics has long been a focus of research, particularly in the context of understanding human evolutionary history. Recently, high-throughput methods have become accessible that allow us to tackle these questions at scale by comparing genomes within and between species, or looking at gene regulatory and expression changes between species and tissues. This burst in large-scale genomic studies has drastically increased the resolution at which we are now able to understand the evolutionary forces acting upon our own species. Read More

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http://dx.doi.org/10.1016/j.gde.2020.06.006DOI Listing

Microbial selenate reduction in membrane biofilm reactors using ethane and propane as electron donors.

Water Res 2020 Jun 13;183:116008. Epub 2020 Jun 13.

Advanced Water Management Centre, The University of Queensland, St Lucia, Brisbane, Queensland, 4072, Australia. Electronic address:

Selenate (Se(VI)) contamination in groundwater is one of major concerns for human health, in particular in shale gas extraction sites. Microbial selenate reduction coupled to methane (CH) oxidation has been demonstrated very recently. Little is known whether ethane (CH) and butane (CH) are able to drive selenate reduction, although they are also important components in shale gas. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116008DOI Listing

Rhizoremediation as a green technology for the remediation of petroleum hydrocarbon-contaminated soils.

J Hazard Mater 2020 Jun 22;401:123282. Epub 2020 Jun 22.

Global Centre for Environmental Remediation (GCER), Advanced Technology Centre (ATC) Building, Faculty of Science, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia. Electronic address:

Rhizoremediation is increasingly becoming a green and sustainable alternative to physico-chemical methods for remediation of contaminated environments through the utilization of symbiotic relationship between plants and their associated soil microorganisms in the root zone. The overall efficiency can be enhanced by identifying suitable plant-microbe combinations for specific contaminants and supporting the process with the application of appropriate soil amendments. This approach not only involves promoting the existing activity of plants and soil microbes, but also introduces an adequate number of microorganisms with specific catabolic activity. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123282DOI Listing

The Comb Sign.

Clin Gastroenterol Hepatol 2020 Jul 4. Epub 2020 Jul 4.

Gastroenterology Staff Specialist, Prince of Wales Hospital.

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http://dx.doi.org/10.1016/j.cgh.2020.06.054DOI Listing

Trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer and brain metastases: exploratory final analysis of cohort 1 from KAMILLA, a single-arm phase IIIb clinical trial.

Ann Oncol 2020 Jul 4. Epub 2020 Jul 4.

Department of Medical Oncology, Guy's Hospital and Sarah Cannon Research Institute, London, UK.

Background: Patients with brain metastases (BM) from human epidermal growth factor receptor 2 (HER2)-positive breast cancer represent a difficult-to-treat population. Trastuzumab emtansine (T-DM1) has shown potential activity in this subset of patients in small clinical series.

Patients And Methods: KAMILLA is an ongoing, phase IIIb study of T-DM1 in patients with HER2-positive locally advanced/metastatic breast cancer (MBC) with prior HER2-targeted therapy and chemotherapy. Read More

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http://dx.doi.org/10.1016/j.annonc.2020.06.020DOI Listing

The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes.

Public Health 2020 Jul 4;185:153-158. Epub 2020 Jul 4.

Institute for Clinical and Experimental Medicine, Department of Gastroenterology and Hepatology, Prague, Czech Republic.

Objectives: Colorectal cancer (CRC) remains a major health burden. Although screening is recommended and considered beneficial, further data on its positive effects are needed for worldwide implementation.

Study Design: The aim of our national multicentre prospective observational study was to reveal and document clinicopathological differences in CRC diagnosed by screening and presented by disease symptoms as well as assess the efficiency of the screening programme in the Czech Republic. Read More

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http://dx.doi.org/10.1016/j.puhe.2020.05.021DOI Listing

Quantification of brain oxygen extraction and metabolism with [O]-gas PET: A technical review in the era of PET/MRI.

Neuroimage 2020 Jul 4:117136. Epub 2020 Jul 4.

Department of Radiology, Stanford University, Stanford CA, USA.

Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117136DOI Listing

Cyclodextrin nanosponge as a Temoporfin nanocarrier: balancing between accumulation and penetration in 3D tumor spheroids.

Eur J Pharm Biopharm 2020 Jul 4. Epub 2020 Jul 4.

Université de Lorraine, CNRS, CRAN, F-54500 Nancy, France; Institut de Cancérologie de Lorraine, 6 avenue de Bourgogne, 54519 Vandoeuvre-lès-Nancy, France.

As the intertissue delivery of hydrophobic temoporfin (mTHPC) remains inefficient, we propose the use of cyclodextrin-based nanosponges as a smart, advanced system for improved mTHPC delivery. Recently, we demonstrated that cyclodextrins (CDs) allow mTHPC to penetrate into tumor spheroids via a nanoshuttle mechanism. However, the CD complexes were very sensitive to the dilution, thus limiting their translation invivo. Read More

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http://dx.doi.org/10.1016/j.ejpb.2020.06.022DOI Listing

Adverse reproductive function induced by maternal BPA exposure is associated with abnormal autophagy and activating inflamation via mTOR and TLR4/NF-κB signaling pathways in female offspring rats.

Reprod Toxicol 2020 Jul 4. Epub 2020 Jul 4.

Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, China. Electronic address:

Bisphenol A (BPA) can affect reproductive function, but its mechanism of reproductive toxicity is unclear, and the effect of BPA on the onset of puberty was inconsistent. The main purpose of this study is to investigate the effects of perinatal exposure to BPA on the onset of puberty and reproductive function, and its mechanism from the aspect of autophagy and inflammation in ovarian and uterus tissues of female offspring. Twenty-one pregnant SD rats were randomly divided into three groups: Control group, 1 μg/mL BPA (LBPA) and 10 μg/mL BPA group (HBPA) via drinking water from gestational day 6 to the end of lactation. Read More

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http://dx.doi.org/10.1016/j.reprotox.2020.07.001DOI Listing

Facile strategy for immobilizing horseradish peroxidase on a novel acetate functionalized ionic liquid/MWCNT matrix for electrochemical biosensing.

Int J Biol Macromol 2020 Jul 4. Epub 2020 Jul 4.

Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore 632014, India. Electronic address:

Facile yet simple platforms for the immobilization of biomolecules have always been a substantial requirement for the fabrication of proficient biosensors. In this study, we report a naphthyl substituted acetate functionalized ionic liquid (NpAc-IL) for the covalent anchoring of horseradish peroxidase (HRP), using which the direct electrochemistry of HRP was successfully accomplished and a HO biosensor was developed. The naphthyl substitution on the NpAc-IL was utilized for the π-π stacking with the MWCNT modified GCE and the terminal -OCH group of NpAc-IL was used for the covalent attachment with the free -NH group of HRP via amide bond formation. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.005DOI Listing

Heterologous expression of lytic polysaccharide monooxygenases (LPMOs). A mini-review.

Biotechnol Adv 2020 Jul 4:107583. Epub 2020 Jul 4.

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1430, Norway. Electronic address:

Lytic polysaccharide monooxygenases (LPMOs) are relatively new enzymes that have been discovered 10 years ago. LPMOs comprise a diverse group of enzymes which play a pivotal role in the depolymerization of sugar-based biopolymers including cellulose, hemicellulose, chitin, and starch. Their mechanism of action relies on the correct coordination of a copper ion in the active site, which is partly composed of the N-terminal histidine. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2020.107583DOI Listing

Detecting caries lesions of different radiographic extension on bitewings using deep learning.

J Dent 2020 Jul 4:103425. Epub 2020 Jul 4.

Department of Oral Diagnostics, Digital Health and Health Services Research, Charité - Universitätsmedizin Berlin, Germany. Electronic address:

Objectives: We aimed to apply deep learning to detect caries lesions of different radiographic extension on bitewings, hypothesizing it to be significantly more accurate than individual dentists.

Methods: 3,686 bitewing radiographs were assessed by four experienced dentists. Caries lesions were marked in a pixelwise fashion. Read More

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http://dx.doi.org/10.1016/j.jdent.2020.103425DOI Listing

In vivo gene delivery mediated by non-viral vectors for cancer therapy.

J Control Release 2020 Jul 4. Epub 2020 Jul 4.

Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul 34956, Turkey; Center of Excellence for Functional Surfaces and Interfaces (EFSUN), Faculty of Engineering and Natural Sciences, Sabanci University, Tuzla, Istanbul 34956, Turkey. Electronic address:

Gene therapy by expression constructs or down-regulation of certain genes has shown great potential for the treatment of various diseases. The wide clinical application of nucleic acid materials dependents on the development of biocompatible gene carriers. There are enormous various compounds widely investigated to be used as non-viral gene carriers including lipids, polymers, carbon materials, and inorganic structures. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.038DOI Listing

A deep learning MR-based radiomic nomogram may predict survival for nasopharyngeal carcinoma patients with stage T3N1M0.

Radiother Oncol 2020 Jul 4. Epub 2020 Jul 4.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing 100191, PR China. Electronic address:

Purpose: To estimate the prognostic value of deep learning (DL) magnetic resonance (MR)-based radiomics for stage T3N1M0 nasopharyngeal carcinoma (NPC) patients receiving induction chemotherapy (ICT) prior to concurrent chemoradiotherapy (CCRT).

Methods: A total of 638 stage T3N1M0 NPC patients (training cohort: n = 447; test cohort: n = 191) were enrolled and underwent MRI scans before receiving ICT+CCRT. From the pretreatment MR images, DL-based radiomic signatures were developed to predict disease-free survival (DFS) in an end-to-end way. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.06.050DOI Listing

Multimodal Theranostics Augmented by Transmembrane Polymer-Sealed Nano-enzymatic Porous MoS Nanoflowers.

Int J Pharm 2020 Jul 4:119606. Epub 2020 Jul 4.

Minhang Hospital and School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China. Electronic address:

Developing an all-in-one multimodal theranostic platform that can synergistically integrate sensitive photoacoustic (PA) imaging, enhanced photothermal therapy (PTT) and photodynamic therapy (PDT) as well as the nano-enzyme activated chemodynamic therapy (CDT) presents a great challenge for the current nanomedicine design. Herein, a simple hydrothermal method was used to prepare porous molybdenum disulfide (MoS) nanoflowers. These nanoflowers were assembled by three dimensional (3D)-stacked MoS nanosheets with plentiful pores and large surfaces, which thus exhibited enhanced photothermal conversion via light trapping and peroxidase (POD)-like activity via active defects exposure. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119606DOI Listing

Autophagy in the crosstalk between tumor and microenvironment.

Cancer Lett 2020 Jul 4. Epub 2020 Jul 4.

UMR E-4320 TIRO-MATOs CEA/DRF/Institut des sciences du vivant Frédéric Joliot, Université Côte d'Azur, Faculté de Médecine, Nice, France. Electronic address:

Autophagy is the major catabolic process in eukaryotic cells for the degradation and recycling of damaged macromolecules and organelles. It plays a crucial role in cell quality control and nutrient supply under stress conditions. Although autophagy is classically described as a degradative mechanism, it can also be involved in some secretion pathways, leading to the extracellular release of proteins, aggregates, or organelles. Read More

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http://dx.doi.org/10.1016/j.canlet.2020.06.015DOI Listing

Inhibition of miR-34a reduces cellular senescence in human adipose tissue-derived mesenchymal stem cells through the activation of SIRT1.

Life Sci 2020 Jul 4:118055. Epub 2020 Jul 4.

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Aims: Human adipose derived mesenchymal stem cells (hAD-MSCs) as the most promising target for cell therapy and regenerative medicine, face senescence as a major drawback resulting in their limited proliferation and differentiation potentials. To evaluate the efficacy of miR-34a silencing as an anti-senescence strategy in hAD-MSCs, in this study common hallmarks of senescence were assessed after transient inhibition of miR-34a in hAD-MSCs.

Materials And Methods: The expression levels of miR-34a in hAD-MSCs at different passages were evaluated by real-time quantitative PCR. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118055DOI Listing

How geographic productivity patterns affect food-web evolution.

J Theor Biol 2020 Jul 4:110374. Epub 2020 Jul 4.

Integrated Science Lab, Department of Mathematics and Mathematical Statistics, UmeåUniversity, SE-90187 Umeå, Sweden; Evolution and Ecology Program, International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, 2361 Laxenburg, Austria.

It is well recognized that spatial heterogeneity and overall productivity have important consequences for the diversity and community structure of food webs. Yet, few, if any, studies have considered the effects of heterogeneous spatial distributions of primary production. Here, we theoretically investigate how the variance and autocorrelation length of primary production affect properties of evolved food webs consisting of one autotroph and several heterotrophs. Read More

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http://dx.doi.org/10.1016/j.jtbi.2020.110374DOI Listing

Fatal fulminant hepatitis induced by combined ipilimumab and nivolumab therapy despite favorable histologic response and confirmed by autopsy in a patient with clear cell renal cell carcinoma.

Immunol Med 2020 Jul 7:1-6. Epub 2020 Jul 7.

Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

Effective management of immune-related adverse events in patients receiving immunotherapy for cancer is problematic. In this report, we present the case of a 58-year-old man with advanced clear cell renal cell carcinoma who responded well to a combination of ipilimumab and nivolumab. However, after two courses of treatment, he developed fulminant hepatitis and died. Read More

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http://dx.doi.org/10.1080/25785826.2020.1788229DOI Listing

Multidisciplinary approaches to the management of malignant pleural effusions: a guide for the clinician.

Expert Rev Respir Med 2020 Jul 7. Epub 2020 Jul 7.

Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Trust , Oxford, UK.

Introduction: Malignant pleural effusion (MPE) is a complication of advanced cancer, associated with significant mortality and morbidity. This entity is commonly treated by respiratory physicians, oncologists and thoracic surgeons. There have been various randomised clinical trials assessing the relative merits of chest drain pleurodesis, indwelling pleural catheters, treatment of septated MPEs, the use of thoracoscopy and pleurodesis and pleurodesis through IPCs in the past decade which have addressed some key areas in the management of MPEs, with an increasing focus on patient related outcome. Read More

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http://dx.doi.org/10.1080/17476348.2020.1793672DOI Listing

A study on clinical outcomes of combination of terlipressin and albumin in Hepatorenal Syndrome.

Scand J Gastroenterol 2020 Jul 7:1-5. Epub 2020 Jul 7.

Department of GI surgery, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Background: Hepatorenal Syndrome (HRS) is a reversible functional renal impairment that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure.

Aim: To evaluate the effect of terlipressin and albumin combination in various clinical outcomes in Hepatorenal Syndrome patients It was a prospective study involving 50 patients with HRS. The effectiveness parameters of the treatments were: confirmed HRS reversal, Recurrence of HRS within 90 days of treatment and mortality rate up to 90 days. Read More

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http://dx.doi.org/10.1080/00365521.2020.1786851DOI Listing

Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole-body metabolic homeostasis.

Am J Physiol Endocrinol Metab 2020 Jul 7. Epub 2020 Jul 7.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 34141 Daejeon, Korea; KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, 34141 Daejeon, Korea.

Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis at both organ and systemic levels. Inositol polyphosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), reportedly control adipocyte functions and energy expenditure. However, the physiological roles of the inositol polyphosphate (IP) pathway in the adipose tissue are not yet fully defined. Read More

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http://dx.doi.org/10.1152/ajpendo.00030.2020DOI Listing

Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease.

J Intern Med 2020 Jul 7. Epub 2020 Jul 7.

University of Buenos Aires, School of Medicine, Institute of Medical Research A Lanari, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Background & Aims: The progression of nonalcoholic fatty liver disease (NAFLD) into severe histological forms (steatohepatitis-NASH) is paralleled by the occurrence of complex molecular processes. Mitochondrial dysfunction is a hallmark feature of advanced disease. Mitochondrially-encoded cytochrome B (cytochrome b, MT-CYB)-a member of the oxidative phosphorylation system, is a key component of the respirasome supercomplex. Read More

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http://dx.doi.org/10.1111/joim.13147DOI Listing

Serum interleukin-10 as a valuable biomarker for early diagnosis and therapeutic monitoring in intravascular large B-cell lymphoma.

Clin Transl Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1002/ctm2.131DOI Listing

Engineered Anisotropic Fluids of Rare Earth Nanomaterials.

Angew Chem Int Ed Engl 2020 Jul 7. Epub 2020 Jul 7.

Tsinghua University, Department of Chemistry, Shuangqing road, 100084, Beijing, CHINA.

The self-assembly of inorganic nanoparticles into well-ordered structures in the absence of solvents is generally hindered by van der Waals forces, leading to random aggregates between them. To address the problem, we functionalized rigid rare earth (RE) nanoparticles with a layer of flexible polymers by electrostatic complexation. Consequently, an ordered and solvent-free liquid crystal (LC) state of RE nanoparticles was realized. Read More

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http://dx.doi.org/10.1002/anie.202007676DOI Listing

A case of pure erythroid leukemia with MYB-GATA1 fusion that developed tumor lysis syndrome with dexamethasone.

Pediatr Blood Cancer 2020 Jul 7:e28285. Epub 2020 Jul 7.

Department of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan.

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http://dx.doi.org/10.1002/pbc.28285DOI Listing

Optimal paramedic numbers in resuscitation of patients with out-of-hospital cardiac arrest: A randomized controlled study in a simulation setting.

PLoS One 2020 7;15(7):e0235315. Epub 2020 Jul 7.

Department of Emergency Medicine, National Taiwan University Hospital, Taipei City, Taiwan.

Background: The effect of paramedic crew size in the resuscitation of patients with out-of-hospital cardiac arrest (OHCA) remains inconclusive. We hypothesised that teams with a larger crew size have better resuscitation performance including chest compression fraction (CCF), advanced life support (ALS), and teamwork performance than those with a smaller crew size.

Methods: We conducted a randomized controlled study in a simulation setting. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235315PLOS

Origin of circulating free DNA in patients with lung cancer.

PLoS One 2020 7;15(7):e0235611. Epub 2020 Jul 7.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.

Liquid biopsy has become widely applied in clinical medicine along with the progress in innovative technologies, such as next generation sequencing, but the origin of circulating tumor DNA (ctDNA) has not yet been precisely established. We reported bimodal peaks of long fragment circulating free DNA (cfDNA) of 5 kb and short fragment cfDNA of 170 bp in patients with advanced lung cancer, and both contained ctDNA. In this paper, we demonstrate that the total amount of cfDNA is higher when patients with lung cancer have extrathoracic metastases, and the amount of long fragment cfDNA is significantly higher in those patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235611PLOS

MicroRNA-21-3p accelerates diabetic wound healing in mice by downregulating SPRY1.

Aging (Albany NY) 2020 Jul 7;12. Epub 2020 Jul 7.

Department of Orthopaedics, Puren Hospital, Wuhan University of Science and Technology, Wuhan 430081, Hubei, China.

A variety of novel drugs and advanced therapeutic strategies have been developed for diabetic foot ulcers (DFUs); however, the clinical outcomes are unsatisfactory and the underlying mechanisms of DFU remain elusive. MicroRNAs (miRNA) regulate the pathological processes of many diseases. Fibroblasts are involved in each stage of wound healing, and the functions of fibroblasts may be regulated by miRNAs. Read More

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http://dx.doi.org/10.18632/aging.103610DOI Listing

Design of Transcutaneous Stimulation Electrodes for Wearable Neuroprostheses.

IEEE Trans Neural Syst Rehabil Eng 2020 Jul;28(7):1651-1660

Ease of use and non-invasiveness has made transcutaneous stimulation a pervasive approach for restoration of hand function. Besides, limited targetability and induced discomfort pose a significant impediment for its clinical translation. By modifying the electrode geometry, we aim to improve the stimulation performance of small surface area electrodes that are suited for forearm muscles. Read More

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http://dx.doi.org/10.1109/TNSRE.2020.2994900DOI Listing

Asynchronous Prediction of Human Gait Intention in a Pseudo Online Paradigm Using Wavelet Transform.

IEEE Trans Neural Syst Rehabil Eng 2020 Jul;28(7):1623-1635

Prediction of human voluntary gait intention is a very significant task to ensure direct cortical control of real-life assistive technologies for locomotion rehabilitation. Neurophysiological studies provide that human voluntary gait intention is represented by slow DC potentials and power shifts in specific frequency ranges of brain wave, which can be detected 1.5- 2 seconds before the actual onset. Read More

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http://dx.doi.org/10.1109/TNSRE.2020.2998778DOI Listing

Current assessment and management of endoleaks after advanced EVAR: new devices, new endoleaks?

Expert Rev Cardiovasc Ther 2020 Jul 7. Epub 2020 Jul 7.

Vascular and Interventional Unit, Department of Radiological Sciences, Policlinico Umberto I, "Sapienza" University of Rome , Rome, Italy.

Introduction In recent years there has been an increasing application of advanced EVAR techniques to tackle complex clinical and anatomical scenarios. In a bid to overcome the limitations of the traditional stent-grafts, newer EVAR endografts and techniques have been developed and introduced into clinical practice, permitting endovascular management of difficult infrarenal, juxta-renal and thoracoabdominal aneurysms for which previously there was no endovascular solution. As a consequence, we are now confronted with unique patterns of endoleak requiring customised clinical-radiological assessment and treatment. Read More

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http://dx.doi.org/10.1080/14779072.2020.1792294DOI Listing

Differential biomarker profiles between unprovoked venous thromboembolism and cancer.

Ann Med 2020 Jul 7:1-26. Epub 2020 Jul 7.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Seville, Spain.

Background: The relationship between cancer and venous thromboembolic disease (VTD) are complex because the activated coagulation factors are not only involved in thrombosis, but also in malignant processes, such as angiogenesis and metastasis.

Objective: To compare phenotypes of extracellular vesicles (EVs), and levels of D-dimer, soluble P-selectin (sP-selectin) and antigenic tissue factor (TF) between unprovoked VTD patients, who did not develop cancer during one year follow-up, and those with advanced stage of cancer but not associated with VTD.

Methods: A prospective study in which we included 138 unprovoked VTD patients and 67 advanced cancer patients, who did not develop thrombosis. Read More

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http://dx.doi.org/10.1080/07853890.2020.1779956DOI Listing

Probing Mg Intercalation in the Tetragonal Tungsten Bronze Framework VNbO.

Inorg Chem 2020 Jul 7. Epub 2020 Jul 7.

Department of Chemistry, University College London, 20 Gower Street, London WC1H 0AJ, U.K.

While commercial Li-ion batteries offer the highest energy densities of current rechargeable battery technologies, their energy storage limit has almost been achieved. Therefore, there is considerable interest in Mg batteries, which could offer increased energy densities in comparison to Li-ion batteries if a high-voltage electrode material, such as a transition-metal oxide, can be developed. However, there are currently very few oxide materials which have demonstrated reversible and efficient Mg insertion and extraction at high voltages; this is thought to be due to poor Mg diffusion kinetics within the oxide structural framework. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.0c01013DOI Listing

Multifaceted Stereo-Selectivity in Polyatomic Reactions.

J Phys Chem A 2020 Jul 7. Epub 2020 Jul 7.

Stereo-selectivity or stereo-requirement refers to the enhancement of chemical reactivity resulting from the preferential alignment/orientation of the colliding reactants. This concept is deeply embodied in the pre-exponential A-factor of the Arrhenius rate expression or the entropy effect of thermal kinetics in physical chemistry textbooks. To understand its dynamical consequence and seek for its mechanistic origin, two different approaches of either selecting the rotational states of the reactant or aligning/orienting the reactant in the laboratory have traditionally been taken. Read More

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http://dx.doi.org/10.1021/acs.jpca.0c04838DOI Listing

Magnetothermia-Induced Catalytic Hollow Nanoreactor for Bioorthogonal Organic Synthesis in Living Cells.

Nano Lett 2020 Jul 7. Epub 2020 Jul 7.

Nanoreactors, where rates of the reactions can be controlled remotely by magnetic fields, have tremendous value in biorthogonal chemistry. Here, we introduce silica-confined magnetothermia-induced nanoreactor (MAG-NER) by growing catalytic Pd-nanocrystal selectively on pre-installed iron oxide core inside hollow silica nanoshell, through magnetic-induction. Due to the activation of interfacial catalytic site by stimulated localized magnetothermia and nano-compartmentalization by size selective porous silica, MAG-NER can be conveniently used in complex bio-media, and even can be internalized into living cells for on-demand high performance intramolecular carbocyclization reaction by the remote operation, without compromising the cell viability while maintaining the high catalytic rates. Read More

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http://dx.doi.org/10.1021/acs.nanolett.0c01507DOI Listing

Training of Hepatology Providers Improves the Screening and Resultant Interventions for Alcohol Use Disorder.

Liver Int 2020 Jul 7. Epub 2020 Jul 7.

Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Central Virginia VA Health Care System, Richmond, Virginia, USA.

Alcohol use disorder (AUD) screening is important but focused training with using AUDIT-10 with counselling/mental health (MH) referral may be needed. We aimed to compare the effect of training on AUD screening/intervention in hepatology clinics in pre versus post-training phases of a quality-improvement initiative. Pre-training encounters were evaluated for inquiry into AUD, AUDIT-10 and MH referrals. Read More

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http://dx.doi.org/10.1111/liv.14589DOI Listing

Cell-free DNA profiling in retinoblastoma patients with advanced intraocular disease: An MSKCC experience.

Cancer Med 2020 Jul 7. Epub 2020 Jul 7.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: The enucleation rate for retinoblastoma has dropped from over 95% to under 10% in the past 10 years as a result of improvements in therapy. This reduces access to tumor tissue for molecular profiling, especially in unilateral retinoblastoma, and hinders the confirmation of somatic RB1 mutations necessary for genetic counseling. Plasma cell-free DNA (cfDNA) has provided a platform for noninvasive molecular profiling in cancer, but its applicability in low tumor burden retinoblastoma has not been shown. Read More

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http://dx.doi.org/10.1002/cam4.3144DOI Listing
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