559 results match your criteria Advanced pharmaceutical bulletin[Journal]


Retraction Note: Expression of Functional Anti-p24 scFv 183-H12-5C in HEK293T and Jurkat T Cells.

Adv Pharm Bull 2018 Nov 29;8(4):727. Epub 2018 Nov 29.

Cluster of Oncology and Radiological Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia.

[This retracts the article DOI: 10.15171/apb.2017. Read More

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http://dx.doi.org/10.15171/apb.2018.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311636PMC
November 2018
1 Read

Overcoming Poor Solubility of Dimenhydrinate: Development, Optimization and Evaluation of Fast Dissolving Oral Film.

Adv Pharm Bull 2018 Nov 29;8(4):721-725. Epub 2018 Nov 29.

Department of Pharmaceutics, Modern College of Pharmacy, Sector 21, Yamunanagar, Nigdi, Pune 411 044, Maharashtra, India.

To develop fast dissolving oral film to address vomiting and nausea in pediatric population. Oral films of Dimenhydrinate were prepared by solvent casting method by using hydroxypropylmethyl cellulose E5 (HPMC E5), polyethylene glycol 400 (PEG 400) and croscarmellose sodium. Solubility of dimenhydrinate was enhanced by ethanol as a co-solvent. Read More

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http://dx.doi.org/10.15171/apb.2018.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311638PMC
November 2018
11 Reads

Determination of the Predictive Value of Serum Bilirubin in Patients with Ischemic Stroke: A Prospective Descriptive Analytical Study.

Adv Pharm Bull 2018 Nov 29;8(4):715-719. Epub 2018 Nov 29.

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

In all types of ischemic stroke, especially in the acute phase, excessive oxidative stress causes structural and functional damage to the brain. This may play a major role in the pathophysiology of the brain damage. Higher serum levels of bilirubin have therapeutic effects in oxidative stress-induced stroke. Read More

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http://dx.doi.org/10.15171/apb.2018.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311645PMC
November 2018

Physiological and Biochemical Effects of Echium Amoenum Extract on Mn-Imposed Parkinson Like Disorder in Rats.

Adv Pharm Bull 2018 Nov 29;8(4):705-713. Epub 2018 Nov 29.

Department of Physiology, Payam Noor University of Iran, Iran.

Manganism is a cognitive disorder take places in peoples are exposed to environmental manganese pollution. Overexposure to manganese ion (Mn) mainly influences central nervous system and causes symptoms that increase possibility of hippocampal damages. In this study rats were administrated by two different doses of MnCl2 and behavioral and physiological consequences were evaluated. Read More

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http://dx.doi.org/10.15171/apb.2018.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311646PMC
November 2018
21 Reads

Metformin Protects Against Radiation-Induced Pneumonitis and Fibrosis and Attenuates Upregulation of Dual Oxidase Genes Expression.

Adv Pharm Bull 2018 Nov 29;8(4):697-704. Epub 2018 Nov 29.

Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Science, Kermanshah, Iran.

Lung tissue is one of the most sensitive organs to ionizing radiation (IR). Early and late side effects of exposure to IR can limit the radiation doses delivered to tumors that are within or adjacent to this organ. Pneumonitis and fibrosis are the main side effects of radiotherapy for this organ. Read More

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http://dx.doi.org/10.15171/apb.2018.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311649PMC
November 2018
4 Reads

Molecular Identification and Probiotic Potential Characterization of Lactic Acid Bacteria Isolated from Human Vaginal Microbiota.

Adv Pharm Bull 2018 Nov 29;8(4):683-695. Epub 2018 Nov 29.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The increased demand for probiotics because of their health purposes provides the context for this study, which involves the molecular identification of lactic acid bacteria (LAB) obtained from the vaginal microbiota of healthy fertile women. The isolates were subjected for examination to prove their probiotic potential. In particular, the isolates were subjected to various tests, including acid/bile tolerance, antimicrobial activity, antibiotic susceptibility, Gram staining, and catalase enzyme activity assessment. Read More

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http://dx.doi.org/10.15171/apb.2018.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311637PMC
November 2018

Inhibits SW480 Cells Growth by Apoptosis Induction.

Adv Pharm Bull 2018 Nov 29;8(4):675-682. Epub 2018 Nov 29.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Streptomyces sp., a dominant genus in Actinomycetes, is the source of a wide variety of secondary metabolites. Microbial metabolites can be utilized as novel anticancer agents; with fewer side effects. Read More

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http://dx.doi.org/10.15171/apb.2018.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311630PMC
November 2018
1 Read

Induces Apoptosis via Gene Expression in Pancreatic Cancer Cells.

Adv Pharm Bull 2018 Nov 29;8(4):667-674. Epub 2018 Nov 29.

Nutrition Research Center, School of Nutrition, Tabriz University of Medical Science, Tabriz, Iran.

Pancreatic adenocarcinoma has a high prevalence all over the world. Most of the therapeutic approaches failed as a result of tumor invasion and rapid metastasis. Several natural plants have been shown to have promising therapeutic effects. Read More

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http://dx.doi.org/10.15171/apb.2018.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311640PMC
November 2018
8 Reads

Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients.

Adv Pharm Bull 2018 Nov 29;8(4):657-666. Epub 2018 Nov 29.

Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Assessment of drug substance and excipients compatibility is an important issue during pre-formulation studies as well as the quality control of pharmaceutical dosage forms. In this study, potential incompatibility between methyldopa and reducing excipients was evaluated using physicochemical methods. Dextrose and lactose (anhydrous & monohydrate) were selected as reducing carbohydrates. Read More

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https://apb.tbzmed.ac.ir/Abstract/apb-19466
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http://dx.doi.org/10.15171/apb.2018.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311631PMC
November 2018
1 Read

An Experimental Study on the Mechanical and Biological Properties of Bio-Printed Alginate/Halloysite Nanotube/Methylcellulose/Russian Olive-Based Scaffolds.

Adv Pharm Bull 2018 Nov 29;8(4):643-655. Epub 2018 Nov 29.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz Iran.

Cartilage shows neither repairs nor regenerative properties after trauma or gradual wear and causes severe pain due to bones rubbing. Bioprinting of tissue-engineered artificial cartilage is one of the most fast-growing sciences in this area that can help millions of people against this disease. Bioprinting of proper bioscaffolds for cartilage repair was the main goal of this study. Read More

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http://dx.doi.org/10.15171/apb.2018.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311641PMC
November 2018
1 Read

Evaluation of Flavonoid Derivative and Doxorubicin Effects in Lung Cancer Cells (A549) Using Differential Pulse Voltammetry Method.

Adv Pharm Bull 2018 Nov 29;8(4):637-642. Epub 2018 Nov 29.

Department of Analytical Chemistry, University of Valencia, Valencia, Spain.

Electrochemical measurements have prompted the progress as a consequence of their affectability, cost-affectivity and comparatively short examination time. The aim of this study was the fast evaluation of the effect of chemotherapy compounds on the viability of lung cancer cells (A549) via electrochemical methods. Cyclic voltammetry (CV) was used as a primary method to distinguish between electrochemical behavior of normal and lung cancer cells. Read More

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http://dx.doi.org/10.15171/apb.2018.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311643PMC
November 2018
2 Reads

Investigating the Cytotoxicity of Folate-Conjugated Bismuth Oxide Nanoparticles on KB and A549 Cell Lines.

Adv Pharm Bull 2018 Nov 29;8(4):627-635. Epub 2018 Nov 29.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Lately, bismuth-based nanomaterials have been widely utilized in medical researches such as imaging, drug delivery and radio-sensitization. Despite their advantages, bismuth-based compounds have shown toxic effects in humans. There are few studies on cytotoxicity effects of bismuth oxide (Bi2O3) nanoparticles (NPs) in-vitro. Read More

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http://dx.doi.org/10.15171/apb.2018.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311633PMC
November 2018
4 Reads

Bio Pharmaceutics Classification System (BCS) Class IV Drug Nanoparticles: Quantum Leap to Improve Their Therapeutic Index.

Adv Pharm Bull 2018 Nov 29;8(4):617-625. Epub 2018 Nov 29.

Department of Biotechnology, Jaypee Institute of Information Technology Noida 201307, India.

Biopharmaceutics classification system (BCS) class IV compounds, exhibits least oral bioavailability, low solubility and intestinal permeability among all pharmaceutical classes of drugs. Thus, these drugs need more compatible and efficient delivery system. Since, their solubility in various medium, remains a limitation so, polymeric nano coacervates based drug loading with modified approach for them may prove to be a solution ahead. Read More

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http://dx.doi.org/10.15171/apb.2018.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311639PMC
November 2018
19 Reads

Development and Characterization of Nanostructured Pharmacosomal Mesophases: An Innovative Delivery System for Bioactive Peptides.

Adv Pharm Bull 2018 Nov 29;8(4):609-615. Epub 2018 Nov 29.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

To potentially enhance the bioavailability and extend the bioactivity effectiveness of Isoleucine-Proline-Proline (IPP, an antihypertensive bioactive peptide of dairy origin), a novel Lyotropic Liquid Crystalline Pharmacosomal Nanoparticle (LLCPNP) was synthesized, and its physicochemical and technological characteristics were studied. LLCPNPs precursors were developed using IPP and soy phosphatidylcholine via complex formation. Polarized light microscopy, small angle X-ray scattering, differential scanning calorimetry, dynamic light scattering and Fourier transform infrared spectroscopy were employed to characterize the physicochemical properties of the nanoparticles. Read More

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http://dx.doi.org/10.15171/apb.2018.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311634PMC
November 2018
2 Reads

Anti-CD24 bio Modified PEGylated Gold Nanoparticles as Targeted Computed Tomography Contrast Agent.

Adv Pharm Bull 2018 Nov 29;8(4):599-607. Epub 2018 Nov 29.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Molecular imaging is one of the import methods for recognition of cancer at the early stage in order to enhance the capacity of remedy. This study was aimed to introduce a new contrast agent that was targeted with CD24 so as to improve the CT scan detection of cancer cells with higher CD24 expression. The surface modifications of gold nanoparticles (Au-NPs) were done with long PEG (HS-PEG-CH3O) and short PEG (HS-PEG-COOH) chains to enhance their stability and capacity for immobilization of different antibodies. Read More

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http://dx.doi.org/10.15171/apb.2018.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311644PMC
November 2018
1 Read

The Impact of CRISPR-Cas System on Antiviral Therapy.

Adv Pharm Bull 2018 Nov 29;8(4):591-597. Epub 2018 Nov 29.

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein nuclease (Cas) is identified as an adaptive immune system in archaea and bacteria. Type II of this system, CRISPR-Cas9, is the most versatile form that has enabled facile and efficient targeted genome editing. Viral infections have serious impacts on global health and conventional antiviral therapies have not yielded a successful solution hitherto. Read More

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http://dx.doi.org/10.15171/apb.2018.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311650PMC
November 2018
8 Reads

A Review of Herbal Therapy in Multiple Sclerosis.

Adv Pharm Bull 2018 Nov 29;8(4):575-590. Epub 2018 Nov 29.

Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Multiple sclerosis is a complex autoimmune disorder which characterized by demyelination and axonal loss in the central nervous system (CNS). Several evidences indicate that some new drugs and stem cell therapy have opened a new horizon for multiple sclerosis treatment, but current therapies are partially effective or not safe in the long term. Recently, herbal therapies represent a promising therapeutic approach for multiple sclerosis disease. Read More

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http://dx.doi.org/10.15171/apb.2018.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311642PMC
November 2018
1 Read

Effects of Prebiotic and Synbiotic Supplementation on Glycaemia and Lipid Profile in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.

Adv Pharm Bull 2018 Nov 29;8(4):565-574. Epub 2018 Nov 29.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Diabetes Mellitus (T2DM) as a chronic disease, is on rise in parallel with other non-communicable diseases. Several studies have shown that probiotics and prebiotics might exert beneficial effects in chronic diseases including diabetes. Because of controversial results from different trials, the present study aims to assess the effects of prebiotic/synbiotic consumption on metabolic parameters in patients with type2 diabetes. Read More

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http://dx.doi.org/10.15171/apb.2018.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311648PMC
November 2018
1 Read

Potential of Peptide Nucleic Acids in Future Therapeutic Applications.

Adv Pharm Bull 2018 Nov 29;8(4):551-563. Epub 2018 Nov 29.

Anatomical Sciences Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker. Considering the unique properties of PNA, including resistance to enzymatic digestion, higher biostability combined with great hybridization affinity toward DNA and RNA, it has attracted great attention toward PNA- based technology as a promising approach for gene alteration. However, an important challenge in utilizing PNA is poor intracellular uptake. Read More

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http://dx.doi.org/10.15171/apb.2018.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311635PMC
November 2018
6 Reads

Transdermal Evaporation Drug Delivery System: Concept to Commercial Products.

Adv Pharm Bull 2018 Nov 29;8(4):535-550. Epub 2018 Nov 29.

Southern Institute of Medical Sciences, College of Pharmacy, Department of Pharmaceutics, SIMS Group of Institutions, Mangaldas Nagar, Vijyawada Road, Guntur-522 001, Andhra Pradesh, India.

Since two decades or so transdermal route established itself as better alternative to traditional oral route. This is possible due to continuous innovations in transdermal drug delivery (TDD), which not only enables researchers from academia and industry to successfully develop and launch many new pharmaceuticals but also allow to include new classes of drugs that can be developed into transdermal formulations. These successes are achieved due to the use of novel techniques based on either physical or chemical approaches. Read More

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http://dx.doi.org/10.15171/apb.2018.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311647PMC
November 2018
2 Reads

Doping in Sports, a Never-Ending Story?

Adv Pharm Bull 2018 Nov 29;8(4):529-534. Epub 2018 Nov 29.

Cluj Municipal Clinical Hospital, Cluj-Napoca, Romania.

Through doping, we understand the use by athletes of substances prohibited by the antidoping agencies in order to gain a competitive advantage. Since sport plays an important role in physical and mental education and in promoting international understanding and cooperation, the widespread use of doping products and methods has consequences not only on health of the athletes, but also upon the image of sport. Thus, doping in sports is forbidden for both ethical and medical reasons. Read More

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http://dx.doi.org/10.15171/apb.2018.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311632PMC
November 2018

Astaxanthin-Rich Algal Hepatic Modulation in D-Galactose-Induced Aging in Rats: Role of Nrf2.

Adv Pharm Bull 2018 Aug 29;8(3):523-528. Epub 2018 Aug 29.

Pharmacology Department, National Research Centre, Giza, Egypt.

Aging is associated with hepatic morphological and physiological deterioration due to the accumulation of endogenous and exogenous free radicals and the resultant oxidative stress. The present study aims to investigate the effect of Haematococcus pluvialis microalgae on hepatic changes associated with D-galactose (D-Gal)-induced aging in rats. Aging was induced in rats by daily intraperitoneal injection of D-Gal (200 mg/kg/day) for eight consecutive weeks. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19472
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http://dx.doi.org/10.15171/apb.2018.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156486PMC
August 2018
1 Read

Presynaptic Activity of an Isolated Fraction from Rhinella schneideri Poison.

Adv Pharm Bull 2018 Aug 29;8(3):517-522. Epub 2018 Aug 29.

School of Medicine Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, SP, Brazil.

Rhinella schneideri is a toad found in many regions of the South America. The poison of the glands has cardiotoxic effect in animals and neuromuscular effects in mice and avian preparation. The purpose of this work was to identify the toxin responsible for the neuromuscular effect in avian and mice neuromuscular preparation. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19511
Publisher Site
http://dx.doi.org/10.15171/apb.2018.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156484PMC
August 2018
1 Read

The Cytotoxic and Antimigratory Activity of Brazilin-Doxorubicin on MCF-7/HER2 Cells.

Adv Pharm Bull 2018 Aug 29;8(3):507-516. Epub 2018 Aug 29.

Departement of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.

Breast cancer cells with overexpression of HER2 are known to be more aggressive, invasive, and resistant to chemotherapeutic agent. Brazilin, the major compound in the Caesalpinia sappan L. (CS) heartwood, has been studied for it's anticancer activity. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19498
Publisher Site
http://dx.doi.org/10.15171/apb.2018.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156471PMC
August 2018
17 Reads

Determining Abuse Deterrence Performance of Poly (ethylene oxide) Using a Factorial Design.

Adv Pharm Bull 2018 Aug 29;8(3):495-505. Epub 2018 Aug 29.

Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida, USA.

The purpose of this study was to determine the effects of thermal processing and antioxidant formulation variables on the abuse deterrence performance of a high molecular weight poly(ethylene oxide) (PEO) polymer. A 2 factorial design with one categorical factor (antioxidant type) and three continuous factors (curing time, curing temperature, % antioxidant) was used. Abuse deterrence performance was evaluated using solution viscosity, surface melting temperature, and mechanical strength. Read More

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http://dx.doi.org/10.15171/apb.2018.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156473PMC
August 2018
19 Reads

Evaluation of NPP1 as a Novel Biomarker of Coronary Artery Disease: A Pilot Study in Human Beings.

Adv Pharm Bull 2018 Aug 29;8(3):489-493. Epub 2018 Aug 29.

Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Coronary artery calcification (CAC) is utilized as an important tool for global risk assessment of cardiovascular events in individuals with intermediate risk. Ecto phosphodiesterase/nucleotide phosphohydrolase-1(ENPP1) converts extracellular nucleotides into inorganic pyrophosphate and it is a key regulator of tissue calcification that adjusts calcification in tissues like vascular smooth muscle cells. The main purpose of this clinical study was to find out the correlation between ENPP1 serum concentration and CAC in human for the first time. Read More

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http://apb.tbzmed.ac.ir/Abstract/APB_19575_20170904192030
Publisher Site
http://dx.doi.org/10.15171/apb.2018.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156488PMC
August 2018
5 Reads

Oleoylethanolamide Supplementation Reduces Inflammation and Oxidative Stress in Obese People: A Clinical Trial.

Adv Pharm Bull 2018 Aug 29;8(3):479-487. Epub 2018 Aug 29.

Nutrition Research Center, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.

Obesity as a serious public health problem worldwide, results in the incidence of many chronic diseases. Obesity has been recognized as a chronic low-grade inflammation disorder. Altered endocannabinoid system tone is also involved in the pathogenesis of obesity. Read More

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http://dx.doi.org/10.15171/apb.2018.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156479PMC
August 2018
19 Reads

Impact of Omega-3 Supplementation on High Sensitive C-Reactive Protein Level and 30-Day Major Adverse Cardiac Events After the Implementation of Coronary Stent in Patients with Chronic Kidney Disease: A Randomized Clinical Study.

Adv Pharm Bull 2018 Aug 29;8(3):471-478. Epub 2018 Aug 29.

Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

Studies have revealed that patients with chronic kidney disease (CKD) are more susceptible to adverse effects of percutaneous coronary intervention (PCI). In addition, the role of elevated high sensitive C-reactive protein (hs-CRP) in the prediction of adverse cardiac outcomes after coronary stent implantation has already been shown. Therefore, in this study, we aimed to evaluate the effect of omega-3 supplementation on hs-CRP and 30-day major adverse cardiac events (MACE) in patients with CKD undergoing elective PCI. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19487
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http://dx.doi.org/10.15171/apb.2018.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156476PMC
August 2018
7 Reads

Dual Preconditioning: A Novel Strategy to Withstand Mesenchymal Stem Cells against Harsh Microenvironments.

Adv Pharm Bull 2018 Aug 29;8(3):465-470. Epub 2018 Aug 29.

Cardiovascular Disease Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Poor survival rate of mesenchymal stem cells (MSCs) following their transplantation is one of the major challenges in their therapeutic application. Therefore, it is necessary to augment the viability of the MSCs in order to improve their therapeutic efficacy. Several strategies have been used to overcome this problem. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19441
Publisher Site
http://dx.doi.org/10.15171/apb.2018.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156477PMC
August 2018
3 Reads

Mummy Material Can Promote Differentiation of Adipose Derived Stem Cells into Osteoblast through Enhancement of Bone Specific Transcription Factors Expression.

Adv Pharm Bull 2018 Aug 29;8(3):457-464. Epub 2018 Aug 29.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Application of Mummy material for treatment of different diseases such as bone fracture, cutaneous wounds and joint inflammation has been advised since hundred years ago in Persian traditional medicine. Due to the claims of indigenous people and advice of traditional medicine for application of this material in healing of bone fractures, this study has been designed to evaluate whether Mummy material can promote the differentiation of mesenchymal stem cells into osteoblasts and enhance the expression of bone specific genes and proteins. Adipose derived stem cells (ASCs) at fourth cell passage were divided into control, osteogenesis group (received osteogenic medium), Mummy group (received Mummy at concentration of 500 µg/ml). Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-20640
Publisher Site
http://dx.doi.org/10.15171/apb.2018.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156472PMC
August 2018
2 Reads

Simulation and Stability Assessment of Anti-EpCAM Immunotoxin for Cancer Therapy.

Adv Pharm Bull 2018 Aug 29;8(3):447-455. Epub 2018 Aug 29.

Department of Biology, Khorasan Razavi Science and Research Branch, Islamic Azad University, Neyshabur, Iran.

Epithelial cell adhesion molecule (EpCAM) is a dominant antigen in human colon carcinoma tissue. Topology features of this antigen are different in normal and malignant conditions; for instance, EpCAM is much less accessible to antibodies in normal cells than in cancerous tissues. Hence, EpCAM has been considered as a suitable candidate for cancer target therapy via immunotoxins (ITs) development. Read More

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http://dx.doi.org/10.15171/apb.2018.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156485PMC
August 2018
31 Reads

Snail-1 Silencing by siRNA Inhibits Migration of TE-8 Esophageal Cancer Cells Through Downregulation of Metastasis-Related Genes.

Adv Pharm Bull 2018 Aug 29;8(3):437-445. Epub 2018 Aug 29.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Snail-1 is a transcription factor, which takes part in EMT, a process related to the emergence of invasion and cancer progression. The purpose of this study was to evaluate the effect of Snail-1 silencing on the human esophageal squamous cell carcinoma cell line, namely TE-8, in vitro. In this study, transfection of Snail-1 specific siRNA was conducted into TE-8 cells. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19431
Publisher Site
http://dx.doi.org/10.15171/apb.2018.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156482PMC
August 2018
2 Reads

Effect of Ghrelin on Caspase 3 and Bcl2 Gene Expression in H2O2 Treated Rat's Bone Marrow Stromal Cells.

Adv Pharm Bull 2018 Aug 29;8(3):429-435. Epub 2018 Aug 29.

Department of Physiology and Pharmacology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

The antiapoptotic effect of ghrelin in various cell lines including bone marrow stromal cells (BMSCs) has been proved. However, the real mechanism of this effect is not clear. Caspase3 and Bcl2 are well-known pro- and antiapoptotic regulatory genes in eukaryotes. Read More

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http://dx.doi.org/10.15171/apb.2018.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156489PMC

Fabrication and Characterization of Gliclazide Nanocrystals.

Adv Pharm Bull 2018 Aug 29;8(3):419-427. Epub 2018 Aug 29.

Department of Pharmaceutics, MNR College of Pharmacy, Sangareddy, Telangana, India.

The main aim of the present investigation was to enhance the solubility of poorly soluble Gliclazide by nanocrystallization. In present investigation gliclazide nanocrystals were prepared by sonoprecipitation using Pluronic F68, Poly Vinyl Alcohol (PVA), Poly ethylene Glycol 6000 (PEG), Poly Vinyl Pyrrolidine (PVP K30) and Sodium Lauryl Sulphate (SLS) as stabilizers. Fourier Transform Infrared Spectroscopic study (FTIR), Differential Scanning Calorimetry (DSC) and X ray diffraction (XRD) studies were conducted to study the drug interactions. Read More

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http://apb.tbzmed.ac.ir/Abstract/APB_19242_20170321195718
Publisher Site
http://dx.doi.org/10.15171/apb.2018.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156478PMC
August 2018
8 Reads

Enhanced Intestinal Permeation of Doxorubicin Using Chitosan Nanoparticles.

Adv Pharm Bull 2018 Aug 29;8(3):411-417. Epub 2018 Aug 29.

Department of Quality Control, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Due to limited oral bioavailability of doxorubicin (Dox) many efforts during the last decades focused on the development of novel delivery systems to overcome these limitations. In the present study, Dox encapsulated chitosan nanoparticles were prepared to evaluate the intestinal permeation of Dox via oral administration. Nanoparticles were fabricated based on ionic gelation method using tripolyphosphate. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19542
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http://dx.doi.org/10.15171/apb.2018.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156480PMC
August 2018
1 Read

Comparison of Pectin Layers for Nicotine Transdermal Patch Preparation.

Adv Pharm Bull 2018 Aug 29;8(3):401-410. Epub 2018 Aug 29.

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.

The objective of the present investigation was to prepare and evaluate transdermal patches for nicotine. Pectin isolated from the hulls of Monthong durian or leaves of Krueo Ma Noy was used as a matrix membrane for the controlled release of nicotine and compared with commercial pectin. The mechanical properties, moisture uptake, and Fourier transform infrared spectra were characterized. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19489
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http://dx.doi.org/10.15171/apb.2018.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156487PMC
August 2018
4 Reads

Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles, , and Characteristics.

Adv Pharm Bull 2018 Aug 29;8(3):395-400. Epub 2018 Aug 29.

Young Researchers and Elite Club, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.

Wound healing is a natural biologic process, but the duration of it may take too long. Trying to shorten this process is one of the challenges for scientists. Many technologies were applied to achieve this goal as well as nanotechnology. Read More

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http://dx.doi.org/10.15171/apb.2018.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156481PMC
August 2018
3 Reads

Targeted Co-Delivery of Docetaxel and cMET siRNA for Treatment of Mucin1 Overexpressing Breast Cancer Cells.

Adv Pharm Bull 2018 Aug 29;8(3):383-393. Epub 2018 Aug 29.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Targeted treatment of breast cancer through combination of chemotherapeutic agents and siRNA had been drawing much attention in recent researches. This study was carried out to evaluate mucin1 aptamer-conjugated chitosan nanoparticles containing docetaxel and cMET siRNA on SKBR3 cells. Nano-drugs were characterized by transmission electron microscope, Zetasizer and loading efficiency calculation. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19589
Publisher Site
http://dx.doi.org/10.15171/apb.2018.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156474PMC
August 2018
2 Reads

Isotretinoin; A review on the Utilization Pattern in Pregnancy.

Adv Pharm Bull 2018 Aug 29;8(3):377-382. Epub 2018 Aug 29.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Isotretinoin is the most effective anti-acne drug with a long-term remission. However; it contains severe teratogenic effects with serious adverse drug reactions, which limits the use of medication. To review the use of isotretinoin during pregnancy, we carried out a comprehensive search of literature in Google Scholar, Scopus and PubMed/Medline from their inception until April 2015. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19464
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http://dx.doi.org/10.15171/apb.2018.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156490PMC
August 2018
1 Read

Natural Phytotherapeutic Antioxidants in the Treatment of Mercury Intoxication-A Review.

Authors:
Velid Unsal

Adv Pharm Bull 2018 Aug 29;8(3):365-376. Epub 2018 Aug 29.

Heavy metals taken into the organism can make the toxic effects on the metabolism in various ways. For example, they may interact with proteins to alter and inhibit their enzymatic and structural functions. Mercury is one of the toxic elements that are widely distributed in nature. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19567
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http://dx.doi.org/10.15171/apb.2018.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156483PMC
August 2018
102 Reads

A Review about Regulatory Status and Recent Patents of Pharmaceutical Co-Crystals.

Adv Pharm Bull 2018 Aug 29;8(3):355-363. Epub 2018 Aug 29.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.

Pharmaceutical Co-crystals are not new, they have gained much attention since the last decade among scientists and pharmaceutical industry. Pharmaceutical co-crystals are multicomponent systems composed of two or more molecules and held together by non-covalent interactions. The development of pharmaceutical co-crystals, a new solid crystalline form, offer superior physico-chemical properties (such as melting point, stability, solubility, permeability, bioavailability, taste masking, etc. Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19525
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http://dx.doi.org/10.15171/apb.2018.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156475PMC
August 2018
4 Reads

Erratum to: Chirality of Modern Antidepressants: An Overview.

Adv Pharm Bull 2018 Jun 19;8(2):353. Epub 2018 Jun 19.

Department of Analytical Chemistry and Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy from Tîrgu Mureș, Tîrgu Mureș, Romania.

[This corrects the article DOI: 10.15171/apb.2017. Read More

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http://dx.doi.org/10.15171/apb.2018.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046425PMC

Effect of on Control of Blood Glucose in Diabetic Critically Ill Patients.

Adv Pharm Bull 2018 Jun 19;8(2):347-351. Epub 2018 Jun 19.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Cucurbita maxima Duchense (C. maxima) has been widely used in China and Mexico as a hypoglycemic plant for controlling blood glucose in diabetic patients. Furthermore, in northwest of Iran, this plant is used traditionally for controlling of diabetes. Read More

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http://dx.doi.org/10.15171/apb.2018.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046431PMC
June 2018
1 Read

Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive.

Adv Pharm Bull 2018 Jun 19;8(2):341-346. Epub 2018 Jun 19.

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.

Ascorbyl palmitate (AP) is a widely used food additive in food industry. In this study, AP was evaluated for potential cyto-genotoxicity on Human Umbilical Vein Endothelial Cells (HUVECs). MTT assay and flow cytometry analysis was used for cytotoxicity evaluation, while genotoxicity was carried out using DAPI staining assays and real time PCR. Read More

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http://dx.doi.org/10.15171/apb.2018.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046424PMC
June 2018
11 Reads

Protective Effect of Gemfibrozil on Hepatotoxicity Induced by Acetaminophen in Mice: the Importance of Oxidative Stress Suppression.

Adv Pharm Bull 2018 Jun 19;8(2):331-339. Epub 2018 Jun 19.

Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Gemfibrozil (GEM) apart from agonist activity at peroxisome proliferator-activated receptor-alpha (PPAR-α) has antioxidant and anti-inflammatory properties. Accordingly, the present study was designed to investigate the protective effect of GEM on acute liver toxicity induced by acetaminophen (APAP) in mice. In this study, mice divided in seven groups include, control group, APAP group, GEM group, three APAP groups pretreated with GEM at the doses of 25, 50 and 100 mg/kg respectively and APAP group pretreated with N-Acetyl cysteine. Read More

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http://dx.doi.org/10.15171/apb.2018.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046434PMC
June 2018
10 Reads

Combination of Vildagliptin and Ischemic Postconditioning in Diabetic Hearts as a Working Strategy to Reduce Myocardial Reperfusion Injury by Restoring Mitochondrial Function and Autophagic Activity.

Adv Pharm Bull 2018 Jun 19;8(2):319-329. Epub 2018 Jun 19.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Diabetic hearts are resistant to cardioprotection by ischemic-postconditioning (IPostC). Protection of diabetic hearts and finding related interfering mechanisms would have clinical benefits. This study investigated the combination effects of vildagliptin (Vilda) and IPostC on cardioprotection and the levels of autophagy and mitochondrial function following myocardial ischemia/reperfusion (I/R) injury in type-II diabetic rats. Read More

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http://dx.doi.org/10.15171/apb.2018.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046419PMC
June 2018
1 Read

Effects of Pharmacologic Dose of Resveratrol Supplementation on Oxidative/Antioxidative Status Biomarkers in Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.

Adv Pharm Bull 2018 Jun 19;8(2):307-317. Epub 2018 Jun 19.

Liver and Gastrointestinal Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.

Despite a proposed role for oxidative stress in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), antioxidant approaches have not been sufficiently investigated in human NAFLD management. Resveratrol has been reported to possess a wide range of biological functions, including antioxidant activities. This study aimed to evaluate the effects of resveratrol supplementation on oxidative/anti-oxidative status in patients with NAFLD. Read More

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http://dx.doi.org/10.15171/apb.2018.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046420PMC
June 2018
2 Reads

An Investigation on the Regenerative Effects of Intra Articular Injection of Co-Cultured Adipose Derived Stem Cells with Chondron for Treatment of Induced Osteoarthritis.

Adv Pharm Bull 2018 Jun 19;8(2):297-306. Epub 2018 Jun 19.

Department of Anatomical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

Adipose tissue derived stem cells (ASCs) and chondrocytes are best cells for articular cartilage regeneration. Chondrocyte with peri-cellular matrix (PCM) is called chondron provides ideal microenviroment than chondrocytes. We aimed to evaluate the regenerative effects of intra-articular injection of ASCs co-cultures with chondron in induced osteoarthritis (OA). Read More

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http://apb.tbzmed.ac.ir/Abstract/apb-19549
Publisher Site
http://dx.doi.org/10.15171/apb.2018.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046423PMC
June 2018
3 Reads

The Effect of Mesenchymal Stem Cell-Derived Microvesicles on Erythroid Differentiation of Umbilical Cord Blood-Derived CD34 Cells.

Adv Pharm Bull 2018 Jun 19;8(2):291-296. Epub 2018 Jun 19.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Mesenchymal stem cells (MSCs) play an important role in the proliferation and differentiation of hematopoietic stem cells (HSCs) in the bone marrow via cell-to-cell contact, as well as secretion of cytokines and microvesicles (MVs). In this study, we investigated the effect of mesenchymal stem cell-derived microvesicles (MSC-MVs) on erythroid differentiation of umbilical cord blood-derived CD34 cells. In this descriptive study, CD34 cells were cultured with mixture of SCF (10 ng/ml) and rhEPO (5 U/ml) cytokines in complete IMDM medium as positive control group. Read More

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http://dx.doi.org/10.15171/apb.2018.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046427PMC
June 2018
2 Reads

Mummy Prevents IL-1β-Induced Inflammatory Responses and Cartilage Matrix Degradation via Inhibition of NF-қB Subunits Gene Expression in Pellet Culture System.

Adv Pharm Bull 2018 Jun 19;8(2):283-289. Epub 2018 Jun 19.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

In Persian traditional medicine, application of Mummy material has been advised since hundred years ago for treatment of different diseases as bone fracture, cutaneous wounds and joint inflammation. Regarding to the claim of indigenous people for application of this material in the treatment of joint inflammation, the present study was designed to evaluate whether Mummy can revoke the inflammatory responses in chondrocytes stimulated with interleukin 1-β (IL-1β). Isolated chondrocytes at the second passage were plated in 50 ml conical tubes at density of 1x10 for pellet culture or were plated in T75 culture flasks as monolayer. Read More

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http://dx.doi.org/10.15171/apb.2018.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046416PMC
June 2018
1 Read