679 results match your criteria Advanced pharmaceutical bulletin[Journal]


Validation and Optimization of Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction as a Preparation Method for Detection of Methadone in Saliva with Gas Chromatography-Mass Spectrometry Technique.

Adv Pharm Bull 2020 Jun 18;10(2):329-333. Epub 2020 Feb 18.

Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.

We investigated validation and optimization of ultrasound-assisted dispersive liquidliquid microextraction (UADLLME) as a preparation method for detection of methadone in saliva samples. We used blank and methadone-containing saliva samples and also standard methadone solution. Sodium hydroxide and chloroform were added to samples and they were held in ultrasonic bath. Read More

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http://dx.doi.org/10.34172/apb.2020.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191241PMC

Expression of Diverse Angiogenesis Factor in Different Stages of the 4T1 Tumor as a Mouse Model of Triple-Negative Breast Cancer.

Adv Pharm Bull 2020 Jun 18;10(2):323-328. Epub 2020 Feb 18.

Cancer Biology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Triple-negative breast cancer (TNBC) is specified by high vascularity and repetitious metastasis. Although several studies have indicated that angiogenesis has an important role in invasive breast cancer, a suitable model of TNBC that can show the exact onset of angiogenesis factors still needs to be developed. The purpose of this study is to determine the expression level of angiogenesis factors in different clinical stages of the 4T1 tumor as TNBC mouse model. Read More

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http://dx.doi.org/10.34172/apb.2020.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191227PMC

Effect of Mesenchymal Stem Cell-derived Microvesicles on Megakaryocytic Differentiation of CD34 Hematopoietic Stem Cells.

Adv Pharm Bull 2020 Jun 20;10(2):315-322. Epub 2020 Feb 20.

Umbilical Cord Blood Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Mesenchymal stem cells (MSCs) release hematopoietic cytokines, growth factors, and Microvesicles (MVs) supporting the hematopoietic stem cells (HSCs). MVs released from various cells, playing a crucial role in biological functions of their parental cells. MSC-derived MVs contain microRNAs and proteins with key roles in the regulation of hematopoiesis. Read More

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http://dx.doi.org/10.34172/apb.2020.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191234PMC

Interleukin-6, -8, and TGF-β Secreted from Mesenchymal Stem Cells Show Functional Role in Reduction of Telomerase Activity of Leukemia Cell Via Wnt5a/β-Catenin and P53 Pathways.

Adv Pharm Bull 2020 Jun 18;10(2):307-314. Epub 2020 Feb 18.

Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The effect of mesenchymal stem cells (MSCs) on the immortality features of malignant cells, such as hematologic cancerous cells, are controversial, and the associated mechanisms are yet to be well understood. The aim of the present study was to investigate the in vitro effect of bone marrow-derived MSCs (BMSCs) on the chronic myeloid leukemia cell line K562 through telomere length measurements, telomerase activity assessments, and gene expression. The possible signaling pathways involved in this process, including Wnt-5a/β-catenin and P53, were also evaluated. Read More

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http://dx.doi.org/10.34172/apb.2020.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191235PMC

Effect of Hypoxia Preconditioned Adipose-Derived Mesenchymal Stem Cell Conditioned Medium on Cerulein-Induced Acute Pancreatitis in Mice.

Adv Pharm Bull 2020 Jun 18;10(2):297-306. Epub 2020 Feb 18.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Acute pancreatitis (AP) is an inflammatory disorder distinguished by tissue injury and inflammation of the pancreas. Using paracrine potential of mesenchymal stem cells (MSCs) provides a useful clinical approach in treating inflammatory diseases. We investigated the therapeutic effects of adipose-derived MSC conditioned medium (CM) and hypoxia preconditioned adipose-derived MSC conditioned medium (HCM) in cerulein-induced AP in mice. Read More

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http://dx.doi.org/10.34172/apb.2020.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191232PMC

Comparison of Linear Poly Ethylene Imine (LPEI) and Poly L-Lysine (PLL) in Fabrication of CHOK Cell-Loaded Multilayer Alginate Microcapsules.

Adv Pharm Bull 2020 Jun 18;10(2):290-296. Epub 2020 Feb 18.

Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Poly l-lysine (PLL) has been introduced as a strengthening covering layer for alginate microcapsules which are the most convenient way for cell encapsulation. Some disadvantages of PLL such as high price and low biocompatibility have prompted scientists to find better alternatives. Linear poly ethylene imine (LPEI), thanks to its highly similar structure to PLL, could be considered as a proper cost-effective alternative. Read More

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http://dx.doi.org/10.34172/apb.2020.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191236PMC

Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial.

Adv Pharm Bull 2020 Jun 18;10(2):284-289. Epub 2020 Feb 18.

Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Stroke is one of the most common conditions causing death. There have been few studies examining the effects of alpha lipoic acid (ALA) on stroke patients. In this regard, the present randomized controlled clinical trial was conducted to examine the effects of ALA supplementation on serum albumin, and inflammatory and oxidative stress markers in stroke patients. Read More

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http://dx.doi.org/10.34172/apb.2020.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191243PMC

Phosphorylation Modulates Survivin Function in Behcet's Disease.

Adv Pharm Bull 2020 Jun 18;10(2):278-283. Epub 2020 Feb 18.

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Survivin is critical for proliferation, maturation, homeostasis and differentiation of effector and memory lymphocytes. In this study the baculoviral inhibitors of apoptosis proteins (IAPs) repeat containing 5 (BIRC5) mRNA, survivin, and phosphorylated survivin expression were evaluated in peripheral blood mononuclear cells (PBMCs), and plasma of patients with Behcet's disease (BD). In this study, 26 Iranian Azari patients diagnosed with BD and 30 healthy controls were recruited. Read More

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http://dx.doi.org/10.34172/apb.2020.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191240PMC

A QSAR Study on the 4-Substituted Coumarins as Potent Tubulin Polymerization Inhibitors.

Adv Pharm Bull 2020 Jun 18;10(2):271-277. Epub 2020 Feb 18.

Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Despite the discovery and synthesis of several anticancer drugs, cancer is still a major life threatening incident for human beings after cardiovascular diseases. Toxicity, severe side effects, and drug resistance are serious problems of available commercial anticancer drugs. Coumarins are synthetic and natural heterocycles that show promising antiproliferative activities against various tumors. Read More

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http://dx.doi.org/10.34172/apb.2020.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191237PMC

Recombinant CagA Regulates Th1/Th2 Balance in a BALB/c Murine Model.

Adv Pharm Bull 2020 Jun 18;10(2):264-270. Epub 2020 Feb 18.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

is recognized as one of the prevalent causes of human gastricinfection. In the present study, the role of mixed immunization with lipopolysaccharide(LPS) and recombinant cytotoxin-associated gene A (rCagA) as a stimulator of host immuneresponses was determined. BALB/c mice were immunized with different formulations by the systemic administrationat 14-day intervals. Read More

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http://dx.doi.org/10.34172/apb.2020.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191242PMC

Characterization and Prospective Applications of the Exopolysaccharides Produced by .

Adv Pharm Bull 2020 Jun 18;10(2):254-263. Epub 2020 Feb 18.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Due to the potential industrial and therapeutic applications of the yeast exopolysaccharides (EPSs), there has been an increasing demand to assess these biopolymers with improved characteristics. This study aimed to characterize the EPSs from (ATCC 90942 and IBRC-M 30088) as well as to evaluate their possible antioxidant, emulsifying and antiproliferative activities. was cultured for 5 days and following isolation of supernatant, EPSs precipitated with adding of cold absolute ethanol and freeze-dried. Read More

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http://dx.doi.org/10.34172/apb.2020.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191244PMC

Surfactant Modified Graphite Paste Electrode as an Electrochemical Sensor for the Enhanced Voltammetric Detection of Estriol with Dopamine and Uric acid.

Adv Pharm Bull 2020 Jun 18;10(2):247-253. Epub 2020 Feb 18.

Department of Chemistry, FMKMC College, Mangalore University Constituent College, Madikeri, Karnataka, India.

Estriol (ERL) is a type of hormone among the groups of estrogen hormone that was detected through the voltammetric technique by constructing an electrochemical sensor based on the octoxynol-9 modified graphite paste electrode (OXL-9MGPE). Using the strategy of cyclic voltammetry (CV) and differential pulse voltammetry (DPV) with a bare graphite paste electrode (BGPE) immobilized with OXL-9, ERL electro-oxidation has been assessed in 0.2 M phosphate buffer solution (PBS) of pH 6. Read More

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http://dx.doi.org/10.34172/apb.2020.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191228PMC

Development and Evaluation of Azelaic Acid-Loaded Microemulsion for Transfollicular Drug Delivery Through Guinea Pig Skin: A Mechanistic Study.

Adv Pharm Bull 2020 Jun 18;10(2):239-246. Epub 2020 Feb 18.

Department of Physics, University of Zabol, Zabol, Iran.

Azelaic acid is a natural keratolytic, comedolytic, and antibacterial drug that is used to treat acne. The topical application of azelaic acid is associated with problems such as irritation and low permeability. For dissolving, the problem is that microemulsion (ME) is used as a drug carrier. Read More

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http://dx.doi.org/10.34172/apb.2020.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191225PMC

Solubilization of Human Interferon β-1b Inclusion Body Proteins by Organic Solvents.

Adv Pharm Bull 2020 Jun 18;10(2):233-238. Epub 2020 Feb 18.

Department of Drug & Food Control, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

Solubilization of inclusion bodies expressed in is a critical step during manufacturing of recombinant proteins expressed as inclusion bodies. So far, various methods have been used for solubilization and purification of inclusion body proteins to obtain active proteins with high purity and yield. The aim of this study was to examine the benefit of organic solvents such as alcohols in solubilization of recombinant interferon β-1b inclusion bodies. Read More

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http://dx.doi.org/10.34172/apb.2020.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191233PMC

All-Trans Retinoic Acid Grafted Poly Beta-Amino Ester Nanoparticles: A Novel Anti-angiogenic Drug Delivery System.

Adv Pharm Bull 2020 Jun 18;10(2):221-232. Epub 2020 Feb 18.

Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran.

Developing chemotherapy with nanoplatforms offers a promising strategy for effective cancer treatment. In the present study, we propose a novel all-trans retinoic acid (ATRA) grafted poly beta-amino ester (PBAE) copolymer for preparing nanoparticles (NPs). ATRA grafted PBAE (ATRA-g-PBAE) copolymer was synthesized by grafting ATRA to PBAE; it was characterized by proton nuclear magnetic resonance, Fourier transform infrared, and thermogravimetric analysis. Read More

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http://dx.doi.org/10.34172/apb.2020.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191239PMC

Cupric Oxide Nanoparticles Induce Cellular Toxicity in Liver and Intestine Cell Lines.

Adv Pharm Bull 2020 Jun 18;10(2):213-220. Epub 2020 Feb 18.

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.

The wide application of cupric oxide nanoparticles (copper (II) oxide, CuO-NPs) in various fields has increased exposure to the kind of active nanomaterials, which can cause negative effects on human and environment health. Although CuO-NPs were reported to be harmful to human, there is still a lack information related to their toxic potentials. In the present study, the toxic potentials of CuO-NPs were evaluated in the liver (HepG2 hepatocarcinoma) and intestine (Caco-2 colorectal adenocarcinoma) cells. Read More

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http://dx.doi.org/10.34172/apb.2020.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191231PMC

Pharmaceutical Co-Crystallization: Regulatory Aspects, Design, Characterization, and Applications.

Adv Pharm Bull 2020 Jun 18;10(2):203-212. Epub 2020 Feb 18.

Faculty of Industrial Pharmacy, Bapuji Pharmacy College, SS layout, Shamnur road, Davanagere-577004, Karnataka, India. Introduction.

Pharmaceutical co-crystals are novel class of pharmaceutical substances, which possess an apparent probability of advancement of polished physical properties offering stable and patentable solid forms. These multi-component crystalline forms influence pertinent physicochemical parameters like solubility, dissolution rate, chemical stability, physical stability, etc. which in turn result in the materials with superior properties to those of the free drug. Read More

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http://dx.doi.org/10.34172/apb.2020.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191238PMC

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review.

Adv Pharm Bull 2020 Jun 18;10(2):184-202. Epub 2020 Feb 18.

Department of Urology, Faculty of Medicine, Gaziosmanpasa University,Tokat, Turkey.

Cadmium (Cd) is a significant ecotoxic heavy metal that adversely affects all biological processes of humans, animals and plants. Exposure to acute and chronic Cd damages many organs in humans and animals (e.g. Read More

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http://dx.doi.org/10.34172/apb.2020.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191230PMC

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics.

Adv Pharm Bull 2020 Jun 18;10(2):166-183. Epub 2020 Feb 18.

School of Pharmacy, SRTM University,Vishnupuri, Nanded- 431606, India.

Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. Read More

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http://dx.doi.org/10.34172/apb.2020.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191229PMC

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery.

Adv Pharm Bull 2020 Jun 18;10(2):150-165. Epub 2020 Feb 18.

Department of Pharmaceutics, I.T.S College of Pharmacy, Muradnagar, Ghaziabad- 201206, Uttar Pradesh, India.

Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. Read More

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http://dx.doi.org/10.34172/apb.2020.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191226PMC

Isolation of Indigenous Selenium Tolerant Yeast and Investigation of the Relationship Between Growth and Selenium Biotransformation.

Adv Pharm Bull 2020 Jan 11;10(1):146-149. Epub 2019 Dec 11.

Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Organic selenium compound such as selenomethionine plays a significant function in the response to oxidative stress. Saccharomyces cerevisiae have the ability to accumulate selenium and selenium biotransformation. Selection of indigenous selenium tolerant yeast is our goals. Read More

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http://dx.doi.org/10.15171/apb.2020.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983986PMC
January 2020

Hollow Alginate-Poly-L-Lysine-Alginate Microspheres Promoted an Epithelial-Mesenchymal Transition in Human Colon Adenocarcinoma Cells.

Adv Pharm Bull 2020 Jan 11;10(1):141-145. Epub 2019 Dec 11.

Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Today, there is an urgent need to develop a three-dimentional culture systems mimicking native condition in order to screen potency of drugs and possibly any genetic alterations in tumor cells. Due to the existence of limitations in animal models, the development of three dimensional systems is highly recommended. To this end, we encapsulated human colon adenocarcinoma cell line HT29 with alginate-poly-L-lysine (Alg-PLL) microspheres and the rate of epithelial-mesenchymal transition was monitored. Read More

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http://dx.doi.org/10.15171/apb.2020.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983985PMC
January 2020

Effect of Whey Protein Supplementation on Inflammatory and Antioxidant Markers, and Clinical Prognosis in Acute Ischemic Stroke (TNS Trial): A Randomized, Double Blind, Controlled, Clinical Trial.

Adv Pharm Bull 2020 Jan 11;10(1):135-140. Epub 2019 Dec 11.

Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Malnutrition is extensively prevalent amongst critically ill patients afflicted by ischemic stroke (IS). This study purpose was to evaluate the protein whey effect on inflammatory and antioxidant markers and functional prognosis in acute IS patients. out of 42 patients with acute IS who were referred to Imam Reza Educational Hospital, Tabriz, Iran, 40 patients participated in the study. Read More

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http://dx.doi.org/10.15171/apb.2020.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983999PMC
January 2020

Restoration of miR-193a-5p and miR-146 a-5p Expression Induces G1 Arrest in Colorectal Cancer through Targeting of MDM2/p53.

Adv Pharm Bull 2020 Jan 11;10(1):130-134. Epub 2019 Dec 11.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Colorectal cancer (CRC) remains a universal and lethal cancer owing to metastatic and relapsing disease. Currently, the role of microRNAs has been checked in tumorigeneses. Numerous studies have revealed that between the tumor suppressor miRNAs, the reduced expression of miR-146a-5p and -193a-5p in several cancers including CRC tissues are related with tumor progression and poor prognosis of patients. Read More

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http://dx.doi.org/10.15171/apb.2020.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983996PMC
January 2020

UT1 Isolated from Northwest of Iran Traditional Curd Exerts Anti-proliferative and Apoptosis Inducing Effects in Human Colorectal Tumor HCT 116 Cells.

Adv Pharm Bull 2020 Jan 11;10(1):125-129. Epub 2019 Dec 11.

Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.

The present study was mainly designed to assess anti-cancer effects of lactobacilli isolated from traditional dairy products, on HCT116 colorectal cancer cell lines. Traditional dairy products samples were collected from the region of Azarbayjan and the suspensions were cultured in MRS agar medium. The isolates were identified by biochemical and molecular methods. Read More

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http://dx.doi.org/10.15171/apb.2020.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983980PMC
January 2020

Toxicity and Anti-promastigote Activity of Benzoxazinoid Analogs Against and .

Adv Pharm Bull 2020 Jan 11;10(1):119-124. Epub 2019 Dec 11.

Laboratório de Parasitologia e Doenças Parasitárias, Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del-Rei (UFSJ), Divinopolis, MG, Brazil.

Here, we aim to evaluate the antileishmanial activity of compounds with a benzoxazinoid (BX) skeleton, previously synthesized by our group, against and promastigotes. Anti-promastigote activity, as well as cytotoxicity, were determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assays. The selectivity index (SI) for each compound was calculated using a ratio of the cytotoxicity of compounds and the geometric mean (GM) of antileishmanial concentrations to each species tested. Read More

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http://dx.doi.org/10.15171/apb.2020.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983991PMC
January 2020

Evaluation of Amikacin Pharmacokinetics in Critically Ill Patients with Intra-abdominal Sepsis.

Adv Pharm Bull 2020 Jan 11;10(1):114-118. Epub 2019 Dec 11.

Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Although the current widespread use of amikacin is in intra-abdominal sepsis treatment, its pharmacokinetic changes in the present setting are not yet well known. This study was aimed to evaluate the amikacin pharmacokinetic profile in critically ill patients with intraabdominal sepsis compared to pneumosepsis. Adult septic patients received amikacin therapy were studied. Read More

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http://dx.doi.org/10.15171/apb.2020.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983982PMC
January 2020

Association of Omentin-1 with Oxidative Stress and Clinical Significances in Patients with Breast Cancer.

Adv Pharm Bull 2020 Jan 11;10(1):106-113. Epub 2019 Dec 11.

Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Breast cancer (BC) is globally the main reason of cancer-related deaths in women. Omentin-1, an anti-inflammatory and antioxidant adipokine, plays different roles in tumorigenesis and anti-oncogenic pathways. In present study, we investigated the association of omentin-1 with oxidative stress and clinical significances in healthy controls and BC patients to assess the prognostic and diagnostic value of omentin-1 in this cancer. Read More

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http://dx.doi.org/10.15171/apb.2020.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983997PMC
January 2020

Classification of Riboswitch Families Using Block Location-Based Feature Extraction (BLBFE) Method.

Adv Pharm Bull 2020 Jan 11;10(1):97-105. Epub 2019 Dec 11.

Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Riboswitches are special non-coding sequences usually located in mRNAs' un-translated regions and regulate gene expression and consequently cellular function. Furthermore, their interaction with antibiotics has been recently implicated. This raises more interest in development of bioinformatics tools for riboswitch studies. Read More

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http://dx.doi.org/10.15171/apb.2020.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983983PMC
January 2020

Resveratrol Effect on Adipose-Derived Stem Cells Differentiation to Chondrocyte in Three-Dimensional Culture.

Adv Pharm Bull 2020 Jan 11;10(1):88-96. Epub 2019 Dec 11.

Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Adipose stem cells (ASCs) are pluripotent cells with the ability of self-renewal and differentiation into different types of mesenchymal cells. As cartilage repair is difficult due to lack of blood capillary, resveratrol (Res) is a polyphenolic compound with diverse biological properties to be possibly used in this case. The aim of the present study was to investigate the effect of Res on differentiation of ASCs into chondrocyte in a three-dimensional (3D) culture model. Read More

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http://dx.doi.org/10.15171/apb.2020.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983992PMC
January 2020

Emerging Effects of Sepantronium Bromide (YM155) on MOLT-4 Cell Line Apoptosis Induction and Expression of Critical Genes Involved in Apoptotic Pathways.

Adv Pharm Bull 2020 Jan 11;10(1):81-87. Epub 2019 Dec 11.

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Sepantronium bromide (YM155) is a Survivin inhibitor which recently advanced as an anticancer agent in phase II clinical trials. Survivin belongs to IAP (inhibitor of apoptosis) gene family and is a pivotal target for treatment due to its overexpression and oncogenic function in many malignancies, including acute lymphoblastic leukemia (ALL). Although survivin is a specific target for YM155, recent reports have shown that it has many other crucial targets that regulate its anti-apoptotic effects. Read More

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http://dx.doi.org/10.15171/apb.2020.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983994PMC
January 2020

Hydrogen Peroxide Preconditioning Promotes Protective Effects of Umbilical Cord Vein Mesenchymal Stem Cells in Experimental Pulmonary Fibrosis.

Adv Pharm Bull 2020 Jan 11;10(1):72-80. Epub 2019 Dec 11.

Marquette University School of Dentistry, Milwaukee, WI, 53233, USA.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder with few available treatments. Mesenchymal stem cell therapy (MSCT), an innovative approach, has high therapeutic potential when used to treat IPF. According to recent data, preconditioning of MSCs can improve their therapeutic effects. Read More

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http://dx.doi.org/10.15171/apb.2020.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983995PMC
January 2020

Alpha7 Nicotinic Acetylcholine Receptor Mediates Nicotine-induced Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma HepG2 Cells.

Adv Pharm Bull 2020 Jan 11;10(1):65-71. Epub 2019 Dec 11.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The cytotoxic properties upon treatment with nicotine have been reported in several studies, but the underlying mechanisms remain not fully defined. The alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the important nicotinic receptors, which nicotine partly by binding to this receptor exerts its effects. The current study aimed to investigates the influences of nicotine on cellular proliferative and apoptotic activities and tried to determine the involvement of α7nAChR in these functions. Read More

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http://dx.doi.org/10.15171/apb.2020.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983989PMC
January 2020

Kinetics Analysis and Susceptibility Coefficient of the Pathogenic Bacteria by Titanium Dioxide and Zinc Oxide Nanoparticles.

Adv Pharm Bull 2020 Jan 11;10(1):56-64. Epub 2019 Dec 11.

Nutrition Research Center, Department of Food Sciences and Technology, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

The increase of bacterial resistance to common antibacterial agents is one of the major problems of health care systems and hospital infection control programs. In this study, antimicrobial activity of titanium dioxide (TiO ) and zinc oxide (ZnO) nanoparticles (NPs) was investigated against , , and pathogenic bacteria by determining sensitivity coefficient and kinetics of bacterial death. Antimicrobial tests were performed with ~10 CFU/mL of each bacterium at baseline. Read More

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http://dx.doi.org/10.15171/apb.2020.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983981PMC
January 2020

Efficient Electrochemical Sensor Based on Gold Nanoclusters/Carbon Ionic Liquid Crystal for Sensitive Determination of Neurotransmitters and Anti-Parkinson Drugs.

Adv Pharm Bull 2020 Jan 11;10(1):46-55. Epub 2019 Dec 11.

Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt.

Herein we introduce a simple and sensitive sensor for the electrochemical determination of neurotransmitters compounds and anti-Parkinson drugs. The electrochemical sensor (Au/CILCE) based on gold nanoclusters modified carbon ionic liquid crystal (ILC) electrode was characterized using scanning electron microscopy and voltammetry measurements. The effect of ionic liquid type in the carbon paste composite for the electro-catalytic oxidation of L-dopa was evaluated. Read More

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http://dx.doi.org/10.15171/apb.2020.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983987PMC
January 2020

Development and Characterization of Nanoliposomal Hydroxyurea Against BT-474 Breast Cancer Cells.

Adv Pharm Bull 2020 Jan 11;10(1):39-45. Epub 2019 Dec 11.

Department of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.

Hydroxyurea (HU) is a well-known chemotherapy drug with several side effects which limit its clinical application. This study was conducted to improve its therapeutic efficiency against breast cancer using liposomes as FDA-approved drug carriers. PEGylated nanoliposomes-containing HU (NL-HU) were made via a thin-film hydration method, and assessed in terms of zeta potential, size, morphology, release, stability, cellular uptake, and cytotoxicity. Read More

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http://dx.doi.org/10.15171/apb.2020.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983993PMC
January 2020

Evaluating Inhibitory Effects of Paclitaxel and Vitamin D Loaded Poly Lactic Glycolic Acid Co-Delivery Nanoparticles on the Breast Cancer Cell Line.

Adv Pharm Bull 2020 Jan 11;10(1):30-38. Epub 2019 Dec 11.

Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Paclitaxel (PTX) has transpired as a significant agent in the treatment of breast cancer. Meanwhile, polylactic glycolic acid (PLGA) nanoparticles (NPs) are able to increase the anticancer effect of the PTX in the blood. Nano-precipitation was used to prepare the PLGA-PTX-VitD3 co-delivery NPs. Read More

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http://dx.doi.org/10.15171/apb.2020.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983998PMC
January 2020

Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine.

Adv Pharm Bull 2020 Jan 11;10(1):20-29. Epub 2019 Dec 11.

Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Rivastigmine hydrogen tartrate (RHT) is commonly used for the treatment of mild to moderate Alzheimer's disease (AD). The aim of this work was to formulate in-situ pluronic F-127 (PF-127) hydrogels containing Eudragit RL-100 (EU-RL) nanoparticles (NPs) in order to improve the therapeutic efficacy of RHT through the nasal route. The NPs were prepared using different polymer to drug ratios and evaluated for their physicochemical characteristics, cellular uptake and in vitro cytotoxicity against lung adenocarcinoma cells (A459). Read More

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http://dx.doi.org/10.15171/apb.2020.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983984PMC
January 2020

An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects.

Adv Pharm Bull 2020 Jan 11;10(1):13-19. Epub 2019 Dec 11.

Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Considering the remarkable application of radiotherapy in the treatment and diagnosis of various diseases and even nuclear war, it is important to protect healthy tissues and people at risk from the radiation. Currently, there is no ideal and safe radioprotective agent available and we are seeing a great effort to find these agents from natural sources. Phenolic compounds, as well as flavonoid, are presented widely as the second metabolite in plants and they have been considered for investigation according to their benefits for human health, healing and preventing many disorders. Read More

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http://dx.doi.org/10.15171/apb.2020.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983988PMC
January 2020

Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery.

Adv Pharm Bull 2020 Jan 11;10(1):1-12. Epub 2019 Dec 11.

Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682041, India.

An ideal colon specific drug delivery system needs to perform multiple functions like greater bio availability, less toxicity and higher therapeutic efficacy, all of which require high degree of smartness. This article focuses on the overview of the stimuli-responsive polymers and various nanodrug delivery systems which have found applications in colon specific delivery of drugs as this system provide a link between therapeutic need and drug delivery. These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration in their structure/properties. Read More

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http://dx.doi.org/10.15171/apb.2020.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983990PMC
January 2020

10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest.

Adv Pharm Bull 2019 Oct 24;9(4):685-689. Epub 2019 Oct 24.

Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.

Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Cell growth was measured by MTT assays, flow cytometry was used to assess cell proliferation, cytotoxicity and cell cycle progression, and western blotting was used to measure cyclin protein expression. Read More

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http://dx.doi.org/10.15171/apb.2019.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912173PMC
October 2019

Molecular Docking and Preclinical Study of Five-Membered S,S-Palladaheterocycle as Hepatoprotective Agent.

Adv Pharm Bull 2019 Oct 24;9(4):674-684. Epub 2019 Oct 24.

Bashkir State Medical University, 3 Lenin Str., 450008 Ufa, Russia.

In order to investigate mechanisms underlying the hepatoprotective action of S,Spalladaheterocycle, inhibition of cytochromes P450 has been modeled by molecular docking of four palladaheterocycle stereoisomers to the active sites of an enzymatic oxidase system. To obtain a deeper insight into biochemical aspects providing a basis for the therapeutic effects of five-membered palladacycles (as mixture of stereoisomers), a number of preclinical trials has been conducted 2D and 3D structures of palladaheterocycle stereoisomers were obtained via converting into SDF files by means of software MarvinSketch. Binding of palladaheterocycle at the active sites of cytochromes P450 2E1 and P450 2C9 has been studied by molecular docking using LeadIT 2. Read More

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http://dx.doi.org/10.15171/apb.2019.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912183PMC
October 2019

The Effect of Bacterial Peptide p28 on Viability and Apoptosis Status of P53-null HeLa Cells.

Adv Pharm Bull 2019 Oct 24;9(4):668-673. Epub 2019 Oct 24.

Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Despite all the efforts for discovery of efficient anti-cancer therapeutics, cancer is still a major health concern worldwide. p28 is a bacterial small peptide which has been widely investigated due to its preferential cell internalization and anti-cancer activities. Intracellularly, p28 offers its anti-cancer traits by impeding the degradation of tumor-suppressor protein "p53". Read More

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http://dx.doi.org/10.15171/apb.2019.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912191PMC
October 2019

Aloe Vera/Collagen Mixture Induces Integrin α1β1 and PECAM-1 Genes Expression in Human Adipose-Derived Stem Cells.

Adv Pharm Bull 2019 Oct 24;9(4):662-667. Epub 2019 Oct 24.

Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Natural biomaterials are a key base in tissue engineering, and collagen, as the main content of the extracellular matrix (ECM), is frequently used in tissue engineering. Aloe vera has some therapeutic effects on ulcers, therefore, the use of this natural resource has always been considered for improving collagen function. We aimed to evaluate the effect of Aloe vera/ Collagen blended on cell viability, cell attachment, and angiogenic potential by determining of integrin α1β1 and platelet endothelial cell adhesion molecule (PECAM-1) genes expression in human adipose-derived stem cells (hASCs). Read More

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http://dx.doi.org/10.15171/apb.2019.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912176PMC
October 2019

Cloning and Overexpression of Strictosidine β-D-Glucosidase Gene Short Sequence from in .

Adv Pharm Bull 2019 Oct 24;9(4):655-661. Epub 2019 Oct 24.

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, Egypt, 32897.

Strictosidine-β-D-glucosidase (SGD) is considered as a key enzyme in the production of bisindole alkaloids in . The present study illustrated the production of a short sequence of this enzyme in without codon optimization. Strictosidine-β-D-glucosidase () gene short sequence (1434 bp), which lacks the conserved sequence KGFFVWS and the localization peptide sequence at the C-terminal, was amplified from cDNA of leaves, cloned and expressed in . Read More

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http://dx.doi.org/10.15171/apb.2019.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912177PMC
October 2019

Assessment of Cytokine Expression Profile of MCF-7 Cells in Response to hWJ-MSCs Secretome.

Adv Pharm Bull 2019 Oct 24;9(4):649-654. Epub 2019 Oct 24.

Medicinal Chemistry Department, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Several attempts have been made to identify the mechanisms by which mesenchymal stem cells (MSCs)-derived secretome exert anti-tumor or tumorigenic effects, but still further investigations are needed to explore this subject. Thus, in this study we want to examine the expression of different cytokines in secretome of hWJ-MSCs and their effects on cytokine expression profile of the MCF-7 tumor cells. The hWJ-MSCs were isolated and characterized according to the International Society for Cellular Therapy criteria. Read More

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http://dx.doi.org/10.15171/apb.2019.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912178PMC
October 2019

The Comparison Between the Mutated HuIFN-β 27-101 and the Wild Type Interferon β: the Comprehensive In Silico Study to Evaluate the Effect of Mutations on IFN-β.

Adv Pharm Bull 2019 Oct 24;9(4):640-648. Epub 2019 Oct 24.

Division of Genetics, Department of Biology, Faculty of Sciences, University of Isfahan, Postal Code: 81746-73441 Isfahan, Iran.

Interferon beta (IFN-β) is used to combat multiple sclerosis (MS) disease. Creating R27T and V101F mutations (mHuIFN-β-27 and mHuIFN-β-101) is one of the tasks performed to improve human interferon beta (HuIFN-β) half-life, function and expression. In this work, the impact of R27T and V101F mutations in recombinant IFN-β on its binding to interferon receptors were studied by molecular docking. Read More

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http://dx.doi.org/10.15171/apb.2019.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912172PMC
October 2019

Evaluation of Immunogenic Effect of Recombinant SAG-1 Antigen with Propranolol as Adjuvant in BALB/c Mice.

Adv Pharm Bull 2019 Oct 24;9(4):632-639. Epub 2019 Oct 24.

Department of Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Propranolol as a novel adjuvant, was used to evaluate the immunogenic effect of three doses of recombinant SAG-1 (rSAG-1) antigen of in BALB/c mice for finding the optimal dose, and was compared with efficacy of tachyzoite lysate antigen (TLA). Eight different groups of 15 BALB/c mice received different volumes of the immunogenic material (three doses of r SAG-1 and one dose of TLA antigens), with or without propranolol adjuvant, subcutaneously. The control group mice received only PBS. Read More

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http://dx.doi.org/10.15171/apb.2019.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912185PMC
October 2019

---Successful Application of Whole Cell Panning for Isolation of Phage Antibody Fragments Specific to Differentiated Gastric Cancer Cells.

Adv Pharm Bull 2019 Oct 24;9(4):624-631. Epub 2019 Oct 24.

Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Generation of antibodies which potentially discriminate between malignant and healthy cells is an important prerequisite for early diagnosis and treatment of gastric cancer (GC). Comparative analysis of cell surface protein landscape will provide an experimental basis for biomarker discovery, which is essential for targeted molecular therapies. This study aimed to isolate phage-displayed antibody fragments recognizing cell surface proteins, which were differently expressed between two closely related GC cell lines, namely AGS and MKN-45. Read More

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http://dx.doi.org/10.15171/apb.2019.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912189PMC
October 2019

Immunomodulatory Activities of Extracts in DMBA-Exposed BALB/c Mouse.

Adv Pharm Bull 2019 Oct 24;9(4):619-623. Epub 2019 Oct 24.

Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia.

Accumulating evidence shows the genus of exerts a broad spectrum of medicinal potencies such as anticancer, antiviral, antibacterial, and antidiabetes. Based on the previous studies, we hypothesized that bioactive compounds of might alter several biological systems, including the immune system. Therefore, this study extensively aimed to evaluate the immunomodulatory activities of extracts in 7,12-dimethylbenz[a] anthracene (DMBA)-treated BALB/c mouse. Read More

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http://dx.doi.org/10.15171/apb.2019.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912186PMC
October 2019