611,437 results match your criteria Advanced materials Deerfield Beach Fla.[Journal]


Q Fever (Coxiella Burnetii).

Semin Respir Crit Care Med 2020 Aug 6;41(4):509-521. Epub 2020 Jul 6.

Department of Pneumology, Hospital Clinic of Barcelona, Barcelona, Spain.

Q fever is a zoonotic infectious disease caused by the bacterium. It is an obligate intracellular pathogen with a high infection capacity that proliferates exclusively in an acidified medium, forming a lysosome-like vacuole. It presents a peculiar phenomenon called "antigenic phase variation," produced by a modification in the complexity of the membrane lipopolysaccharides. Read More

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http://dx.doi.org/10.1055/s-0040-1710594DOI Listing

Impact of Disconnected Pancreatic Duct Syndrome on Endoscopic Ultrasound-Guided Drainage of Pancreatic Fluid Collections.

Endoscopy 2020 Jul 6. Epub 2020 Jul 6.

Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, United States.

Background/aims: Endoscopic intervention for pancreatic fluid collections (PFCs) with disconnected pancreatic duct syndrome (DPDS) has been associated with failures and increased need for additional endoscopic and non-endoscopic interventions. The primary aim of this study is to determine outcomes of EUS-guided transmural drainage of PFCs in patients with DPDS.

Methods: In patients undergoing EUS-guided drainage of PFCs from 1/2013 to 1/2018, demographic profiles, procedural indications and details, adverse events, outcomes, and subsequent interventions were retrospectively collected. Read More

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http://dx.doi.org/10.1055/a-1213-1489DOI Listing

Comparison between Fluoropyrimidine-Cisplatin and Gemcitabine-Cisplatin as First-Line Chemotherapy for Advanced Biliary Tract Cancer: A Meta-Analysis.

Oncol Res Treat 2020 Jul 6:1-9. Epub 2020 Jul 6.

Department of Hematology, The First People's Hospital of Yuhang District, Hangzhou, China.

Background: Gemcitabine-cisplatin (GP) has been regarded as standard first-line chemotherapy for advanced biliary tract cancer (BTC). Fluoropyrimidine-cisplatin (FP) has also shown a survival benefit. However, the clinical choice between them is controversial. Read More

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http://dx.doi.org/10.1159/000507093DOI Listing

Phase III Randomized Study of Induction Chemotherapy Followed by Definitive Radiotherapy + Cetuximab Versus Chemoradiotherapy in Squamous Cell Carcinoma of Head and Neck: The INTERCEPTOR-GONO Study (NCT00999700).

Oncology 2020 Jul 6:1-8. Epub 2020 Jul 6.

Statistic Unit, Genova University, Genova, Italy.

Objectives: Induction chemotherapy followed by cetuximab and RT (IBRT) (Arm A) was compared to cisplatin/RT (CRT) (Arm B) in a randomized phase III study.

Patients And Methods: Naïve patients with stage III-IVa, histologically proven locally advanced head and neck cancer (LASCCHN) were eligible. Arm A (IBRT): 3 TPF induction followed by cetuximab-RT (equivalent daily dose 2 Gy up to 70 Gy); Arm B: 3 cisplatin concurrent with the same RT scheduling. Read More

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http://dx.doi.org/10.1159/000507733DOI Listing

Electronic coupling in square planar LaNiO.

J Phys Condens Matter 2020 Jul 6. Epub 2020 Jul 6.

Materials Science Division, Argonne National Laboratory, Lemont, Illinois, UNITED STATES.

A study of a dd excitation in La4<\sub>Ni3<\sub>O8<\sub> (La-438) using x-ray absorption scattering (XAS) and resonant inelastic x-ray scattering (RIXS) at the Ni K-edge is presented. The incident energy dependence of this dd excitation shows a maximum at the 1s→4pπ<\sub> transition. Its intensity at the main edge is proportional to the amount of incident x-ray polarization parallel to the c-axis. Read More

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http://dx.doi.org/10.1088/1361-648X/aba314DOI Listing

Synthesis, structural, spectral and antimicrobial activity studies of copper-nalidixic acid complex with 1,10-phenanthroline: DFT and molecular docking.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 25;241:118639. Epub 2020 Jun 25.

Ondokuz Mayıs University, Faculty of Arts and Sciences, Physics Department, Samsun, Turkey.

The mix-ligand coordination compound, [Cu(Nal)(Phen)(HO)].(Phen).ClO. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118639DOI Listing

Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3.

EBioMedicine 2020 Jul 3;57:102862. Epub 2020 Jul 3.

Reference and Translation Center for Cardiac Stem Cell Therapy, Department Life, Light and Matter and Department of cardiac surgery, University Medicine Rostock, Schillingallee 35, 18055 Rostock, Germany. Electronic address:

Background: Bone marrow stem cell clonal dysfunction by somatic mutation is suspected to affect post-infarction myocardial regeneration after coronary bypass surgery (CABG).

Methods: Transcriptome and variant expression analysis was studied in the phase 3 PERFECT trial post myocardial infarction CABG and CD133 bone marrow derived hematopoetic stem cells showing difference in left ventricular ejection fraction (∆LVEF) myocardial regeneration Responders (n=14; ∆LVEF +16% day 180/0) and Non-responders (n=9; ∆LVEF -1.1% day 180/0). Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102862DOI Listing

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer.

EBioMedicine 2020 Jul 3;57:102858. Epub 2020 Jul 3.

Department of Gastroenterology and Pancreatology, CHU - Rangueil and University of Toulouse, Toulouse, France.

Background: A significant gap in pancreatic ductal adenocarcinoma (PDAC) patient's care is the lack of molecular parameters characterizing tumours and allowing a personalized treatment.

Methods: Patient-derived xenografts (PDX) were obtained from 76 consecutive PDAC and classified according to their histology into five groups. A PDAC molecular gradient (PAMG) was constructed from PDX transcriptomes recapitulating the five histological groups along a continuous gradient. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102858DOI Listing

The smart use of smartphones in pediatrics.

Authors:
Susan Solecki

J Pediatr Nurs 2020 Jun 26;55:6-9. Epub 2020 Jun 26.

Drexel University, College of Nursing and Health Professions, 915 Three Parkway, Philadelphia, PA 19102, United States of America. Electronic address:

The problematic overuse of electronic devices, in particular smartphones, is negatively affecting the lives of American youth. Cell phone technology has advanced its capabilities with smartphones to now easily provide children and teens with endless access to the internet, social media, and other online activities. Research is showing that addictive, smart phone activities of youth in their formative years is directly impacting their wellbeing. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.06.001DOI Listing

Flavobacterium pokkalii sp. nov., a novel plant growth promoting native rhizobacteria isolated from pokkali rice grown in coastal saline affected agricultural regions of southern India, Kerala.

Microbiol Res 2020 Jun 23;240:126533. Epub 2020 Jun 23.

Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695 019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, 110 001, India. Electronic address:

Nine plant-associated bacterial strains designated as L1I52, NRK F1, NRK F15, NRK F16, NRK F41, NRK F42, NRK F47, NRK F49, and NRK F50 originating from the roots and rhizosphere region of a coastal saline tolerant pokkali rice were taxonomically characterized in this study. Genomic fingerprinting using Enterobacterial Repetitive Intergenic Consensus (ERIC) primers discriminated the nine strains based on the DNA fingerprint patterns indicating that they were not clonal in origin. Phylogenetic analysis using 16S rRNA and other five housekeeping genes (gyrB, glyA, atpA, dnaK and murG) revealed that the novel strains constituted a single novel species within the genus Flavobacterium. Read More

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http://dx.doi.org/10.1016/j.micres.2020.126533DOI Listing

Advanced utilization of copper in waste printed circuit boards: Synthesis of nano-copper assisted by physical enrichment.

J Hazard Mater 2020 Jun 23;401:123294. Epub 2020 Jun 23.

College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao, Shandong 266590, China. Electronic address:

The copper in the waste printed circuit boards (WPCBs) is cleanly recycled by physical methods and presented in the form of nano copper particles by hydrometallurgical, which provides environmental approach to the advanced utilization of metal copper. Copper in WPCBs was first pre-concentrated by gradient enrichment process including gravity separation, mechanical grinding and flotation. The leaching method was then used to dissolve copper from the flotation concentrate in ammoniacal/ammonium salt solutions. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123294DOI Listing

Simultaneous generation of acrylamide, β-carboline heterocyclic amines and advanced glycation ends products in an aqueous Maillard reaction model system.

Food Chem 2020 Jun 20;332:127387. Epub 2020 Jun 20.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:

The simultaneous formation of acrylamide; β-carboline heterocyclic amines (HAs): harmane and norharmane; and advanced glycation end products (AGEs) (N-(carboxymethyl)lysine (CML) and N-(carboxyethyl)lysine (CEL)) was analyzed based on an aqueous model system. The model systems included lysine-glucose (Lys/Glu), asparagine-glucose (Asn/Glu), tryptophan-glucose (Trp/Glu), and a mixture of these amino acids (Mix/Glu). Only AGEs were generated when heated at 100 °C, Asn and Trp competed with Lys for glucose and methylglyoxal (MGO), and glyoxal (GO) decreased AGE content. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127387DOI Listing

Treatment technologies and degradation pathways of glyphosate: A critical review.

Sci Total Environ 2020 Jun 28;742:140559. Epub 2020 Jun 28.

Aix Marseille University, CNRS, Centrale Marseille, M2P2, Marseille, France. Electronic address:

Glyphosate is one of the most widely used post-emergence broad-spectrum herbicides in the world. This molecule has been frequently detected in aqueous environment and can cause adverse effects to plants, animals, microorganisms, and humans. This review offers a comparative assessment of current treatment methods (physical, biological, and advanced oxidation process) for glyphosate wastewaters, considering their advantages and drawbacks. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140559DOI Listing

Temperature and salinity drive comammox community composition in mangrove ecosystems across southeastern China.

Sci Total Environ 2020 Jun 24;742:140456. Epub 2020 Jun 24.

Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, PR China. Electronic address:

Complete ammonia-oxidizing (comammox) microorganisms are newly recognized nitrifying bacteria found in natural and engineered ecosystems. Mangrove ecosystems are hotspots for nitrogen cycling, but the knowledge of comammox diversity and abundance, and particularly, driving factors, in these ecosystems is scarce. We here used deep sequencing to investigate comammox diversity in six mangrove ecosystems across southeastern China. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140456DOI Listing

Selection of optimum biological treatment for coking wastewater using analytic hierarchy process.

Sci Total Environ 2020 Jun 20;742:140400. Epub 2020 Jun 20.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China. Electronic address:

The design of biological treatment process for the coking wastewater (CW) is complicated since wastewater treatment demand is gradually increasing lacking the systematic strategy in efficiency evaluation and advisable selection. Therefore, this study develops a holistic approach by means of the analytic hierarchy process (AHP) that uses numerical representation to rank the preferences of each participating alternatives for evaluation of the advanced biological technologies in CW treatment. Based on survey results, six types reactor combinations were selected as the alternatives, which were further classified as two group according to COD load. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140400DOI Listing

Analytical and fast Fiber Orientation Distribution reconstruction in 3D-Polarized Light Imaging.

Med Image Anal 2020 Jun 27;65:101760. Epub 2020 Jun 27.

Athena Project-Team, Inria Sophia Antipolis-Méditerranée, Université Côte d'Azur, France.

Three dimensional Polarized Light Imaging (3D-PLI) is an optical technique which allows mapping the spatial fiber architecture of fibrous postmortem tissues, at sub-millimeter resolutions. Here, we propose an analytical and fast approach to compute the fiber orientation distribution (FOD) from high-resolution vector data provided by 3D-PLI. The FOD is modeled as a sum of K orientations/Diracs on the unit sphere, described on a spherical harmonics basis and analytically computed using the spherical Fourier transform. Read More

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http://dx.doi.org/10.1016/j.media.2020.101760DOI Listing

Computational fluid dynamics modelling of human upper airway: A review.

Comput Methods Programs Biomed 2020 Jun 26;196:105627. Epub 2020 Jun 26.

Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background And Objective: Human upper airway (HUA) has been widely investigated by many researchers covering various aspects, such as the effects of geometrical parameters on the pressure, velocity and airflow characteristics. Clinically significant obstruction can develop anywhere throughout the upper airway, leading to asphyxia and death; this is where recognition and treatment are essential and lifesaving. The availability of advanced computer, either hardware or software, and rapid development in numerical method have encouraged researchers to simulate the airflow characteristics and properties of HUA by using various patient conditions at different ranges of geometry and operating conditions. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105627DOI Listing

Using taTME to maintain restorative options in locally advanced rectal cancer: A technical note.

Int J Surg Case Rep 2020 Jun 12;73:39-43. Epub 2020 Jun 12.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, Australia; University of Melbourne, Melbourne, Australia. Electronic address:

Background: The safe adoption of transanal total mesorectal excision (taTME) has occurred in Australasia as previously reported by the current authors. Planes beyond TME can be utilised in more advanced cases to achieve negative margins during transanal dissection.

Methods: In this article we describe how taTME is used to perform an en-bloc partial vaginectomy and aid restore intestinal and vaginal continuity in a young female with a locally advanced rectal cancer and posterior vaginal wall involvement in the pre-treatment magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.015DOI Listing

Improvement of organisms by biomimetic mineralization: a material incorporation strategy for biological modification.

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, 310027 China; Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, 310027 China. Electronic address:

Biomineralization, a bio-organism controlled mineral formation process, plays an important role in linking biological organisms and mineral materials in nature. Inspired by biomineralization, biomimetic mineralization is used as a bridge tool to integrate biological organisms and functional materials together, which can be beneficial for the development of diversified functional organism-material hybrids. In this review, recent progresses on the techniques of biomimetic mineralization for organism-material combinations are summarized and discussed. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.038DOI Listing

Lateralized Connectivity between Globus Pallidus and Motor Cortex is Associated with Freezing of Gait in Parkinson's Disease.

Neuroscience 2020 Jul 3. Epub 2020 Jul 3.

Department of Behavioral Neuroscience, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97239, United States; Department of Biomedical Engineering, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97239, United States; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97239, United States. Electronic address:

Freezing of gait (FoG) is a brief, episodic absence or marked reduction of forward progression of the feet, despite the intention to walk, that is common in people with Parkinson's disease (PD). We hypothesized that not only motor, but higher level cognitive and attention areas may be impaired in freezers. In this study, we aimed to characterize differences in cortical and subcortical functional connectivity specific to FoG. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.06.036DOI Listing

Modal analysis and moving performance of a single-mode linear ultrasonic motor.

Ultrasonics 2020 Jun 29;108:106216. Epub 2020 Jun 29.

Suzhou Changfeng Avionics Co., Ltd., AVIC, Suzhou 215151, PR China.

A single-mode linear ultrasonic motor was developed in this study. On the stator, a group of four pieces of piezoelectric ceramics PZT8 were utilized to generate the ultrasonic vibration. A specially designed modal conversion horn with an oblique beam was applied to transfer the longitudinal vibration to an additional bending vibration. Read More

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http://dx.doi.org/10.1016/j.ultras.2020.106216DOI Listing

ALS, a cellular whodunit on motor neuron degeneration.

Mol Cell Neurosci 2020 Jul 3:103524. Epub 2020 Jul 3.

Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), Kyoto, Japan; Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan. Electronic address:

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily targets motor neurons. Motor neurons from ALS patients show cytoplasmic inclusions that are reflective of an altered RNA metabolism and protein degradation. Causal gene mutations are found in all cell types even though patient motor neurons are by far the most susceptible to the degeneration. Read More

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http://dx.doi.org/10.1016/j.mcn.2020.103524DOI Listing

Xylanase immobilization onto trichlorotriazine-functionalized polyethylene glycol grafted magnetic nanoparticles: A thermostable and robust nanobiocatalyst for fruit juice clarification.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.

The covalent immobilization of xylanase onto the trichlorotriazine-functionalized polyethylene glycol grafted magnetic nanoparticles was exploited to generate a stabilized xylanase with improved catalytic activity and stability. Several tools were deployed to monitor the synthesis and immobilization processes, the loading capacity of nanocarrier, and the structural/chemical characteristics of the nanobiocatalyst. The optimum immobilization yield of xylanase was 260 mg xylanase/g nanocarrier in 20 mM phosphate buffer, pH 6. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.273DOI Listing

Development of sustainable magnetic chitosan biosorbent beads for kinetic remediation of arsenic contaminated water.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

Department of Chemistry, University of Agriculture, Faisalabad 38000, Pakistan.

We report the preparation of both control chitosan and magnetic chitosan beads as biosorbents using chitosan as matrix and magnetite (FeO) nanoparticles as reinforcement followed by detailed advanced characterization. The batch trials were performed to study the adsorption kinetics of biosorbents by removing As and As species from water systems. The experimental data was inserted into Langmuir and Freundlich's isotherms to undertake the mechanism and adsorption capacity of the test biosorbents. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.287DOI Listing

Self-assembled DNA nanoparticles loaded with Travoprost for Glaucoma-treatment.

Nanomedicine 2020 Jul 3:102260. Epub 2020 Jul 3.

Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747, AG, Groningen, The Netherlands; DWI - Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany; Institute for Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074, Aachen, Germany. Electronic address:

Lipid DNA nanoparticles (NPs) exhibit an intrinsic affinity to the ocular surface and can be loaded by hybridization with fluorophore-DNA conjugates or with the anti-glaucoma drug travoprost by hybridizing an aptamer that binds the medication. In the travoprost-loaded NPs (Trav-NPs), the drug is bound by specific, non-covalent interactions, not requiring any chemical modification of the active pharmaceutical ingredient. Fluorescently labeled Trav-NPs show a long-lasting adherence to the eye, up to sixty minutes after eye drop instillation. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102260DOI Listing

Motor neuroplasticity: A MEG-fMRI study of motor imagery and execution in healthy ageing.

Neuropsychologia 2020 Jul 3:107539. Epub 2020 Jul 3.

ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, Australia; Department of Cognitive Science, Macquarie University, Sydney, Australia; Perception in Action Research Centre, Faculty of Human Sciences, Macquarie University, Sydney, Australia.

Age-related decline in motor function is associated with over-activation of the sensorimotor circuitry. Using a multimodal MEG-fMRI paradigm, we investigated whether this neural over-recruitment in old age would be related to changes in movement-related beta desynchronization (MRBD), a correlate of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), and whether it would characterize compensatory recruitment or a reduction in neural specialization (dedifferentiation). We used MEG to assess age-related changes in beta band oscillations in primary motor cortices, fMRI to localize age-related changes in brain activity, and the Finger Configuration Task to measure task performance during overt and covert motor processing: motor execution (ME) and motor imagery (MI). Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2020.107539DOI Listing

Identification of human glycerophosphodiesterase 3 as an ecto phospholipase C that converts the G protein-coupled receptor 55 agonist lysophosphatidylinositol to bioactive monoacylglycerols in cultured mammalian cells.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 3:158761. Epub 2020 Jul 3.

Graduate School of Biomedical Sciences, Tokushima University, 1-78-1 Shomachi, Tokushima 770-8505, Japan; Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan. Electronic address:

A family of glycerol-based lysolipid mediators comprises lysophosphatidic acid as a representative phospholipidic member but also a monoacylglycerol as a non-phosphorus-containing member. These critical lysolipid mediators are known to be produced from different lysophospholipids by actions of lysophospholipases C and D in mammals. Some members of the glycerophosphodiesterase (GDE) family have attracted recent attention due to their phospholipid-metabolizing activity. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158761DOI Listing

The past, present and future of intestinal in vitro cell systems for drug absorption studies.

J Pharm Sci 2020 Jul 3. Epub 2020 Jul 3.

Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address:

The intestinal epithelium acts as a selective barrier for the absorption of water, nutrients and orally administered drugs. To evaluate the gastrointestinal permeability of a candidate molecule, scientists and drug developers have a multitude of cell culture models at their disposal. Static transwell cultures constitute the most extensively characterized intestinal in vitro system and can accurately categorize molecules into low, intermediate and high permeability compounds. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.07.001DOI Listing

Type 5 phosphodiesterase (PDE5) and the vascular tree: from embryogenesis to aging and disease.

Mech Ageing Dev 2020 Jul 3:111311. Epub 2020 Jul 3.

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. Electronic address:

Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111311DOI Listing

Microvascular Reconstruction of Total Maxillary Avascular Necrosis as a Complication of Routine Orthognathic Surgery.

J Oral Maxillofac Surg 2020 Jun 10. Epub 2020 Jun 10.

Assistant Professor and Division Chair, Section of Head and Neck Oncologic Surgery and Reconstruction, Division of Oral and Maxillofacial Surgery, Department of Surgery, Mayo Clinic and Mayo College of Medicine, Rochester, MN.

Severe complications and morbidity after orthognathic surgery are infrequently encountered and have been even more infrequently reported considering the extent to which this procedure is performed by surgeons within the specialty of maxillofacial surgery. Avascular necrosis of the maxilla after Le Fort I osteotomy is perhaps the most dreaded outcome of orthognathic surgery. However, it accounts for an extremely small subset of overall surgical complications. Read More

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http://dx.doi.org/10.1016/j.joms.2020.06.009DOI Listing

Levodopa Positively Affects Neovascular Age-related Macular Degeneration.

Am J Med 2020 Jul 3. Epub 2020 Jul 3.

Snyder Biomedical Corporation, Tucson, AZ 85712, USA; Department of Biomedical Engineering, The University of Arizona, Tucson, AZ, 85721, USA.

Background: Age-related macular degeneration (AMD) is a common cause of blindness worldwide. Neovascular AMD (nAMD) is an advanced form of the disease, in which excess vascular endothelial growth factor (VEGF) induces growth of new blood vessels that leak fluid, accounting for 90% of vision loss in AMD. Dysfunction of the retinal pigment epithelium likely initiates AMD. Read More

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http://dx.doi.org/10.1016/j.amjmed.2020.05.038DOI Listing

Anti-amoebic potential of azole scaffolds and nanoparticles against pathogenic Acanthamoeba.

Acta Trop 2020 Jul 3:105618. Epub 2020 Jul 3.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.

Acanthamoeba spp. are free living amoeba (FLA) which are widely distributed in nature. They are opportunistic parasites and can cause severe infections to the eye, skin and central nervous system. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105618DOI Listing

Rh(III)-Catalyzed C(sp)-H Acetoxylation of 8-Methylquinolines.

Org Lett 2020 Jul 6. Epub 2020 Jul 6.

Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China.

A mild and efficient Rh(III)-catalyzed aliphatic C-H acetoxylation directed by quinolines has been developed with widespread functional groups, including various halogens, which usually can provide precursors for further organic synthesis but easily results in selectivity issues in the Pd- and Ni-catalyzed reaction. Interestingly, AcO plays an essential role in promoting the transformation. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01715DOI Listing

Symmetry Dictated Grain Boundary State in a Two-Dimensional Topological Insulator.

Nano Lett 2020 Jul 6. Epub 2020 Jul 6.

Korea Institute for Advanced Study, Seoul 02455, Korea.

Grain boundaries (GBs) are ubiquitous in solids and have been of central importance in understanding the nature of polycrystals. In addition to their classical roles, topological insulators (TIs) offer a chance to realize GBs hosting distinct topological states that can be controlled by their crystal symmetries. However, such roles of crystalline symmetry in two-dimensional (2D) TIs have not been definitively measured yet. Read More

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http://dx.doi.org/10.1021/acs.nanolett.0c01756DOI Listing

Comprehensive analysis of 5-hydroxymethylcytosine in zw10 kinetochore protein as a promising biomarker for screening and diagnosis of early colorectal cancer.

Clin Transl Med 2020 Jul 6. Epub 2020 Jul 6.

Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: As a new epigenetic biomarker, 5-hydroxymethylcytosine (5hmC) is broadly involved in various diseases including cancers. However, the function and diagnostic performance of 5hmC in colorectal cancer (CRC) remain unclear.

Results: High-throughput sequencing was used to profile 5hmC levels in adjacent normal colon, advanced adenomas, and CRC. Read More

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http://dx.doi.org/10.1002/ctm2.125DOI Listing

The Geometry of the roots of the Brachial Plexus.

J Anat 2020 Jul 6. Epub 2020 Jul 6.

Leeds Institute for Medical Research, University of Leeds, Leeds, UK.

Diffusion tensor magnetic resonance imaging (DTI) can be used to reconstruct the brachial plexus in 3D via tracts connecting contiguous diffusion tensors with similar primary eigenvector orientations. When creating DTI tractograms, the turning angle of connecting lines (step angle) must be prescribed by the user; however, the literature is lacking detailed geometry of brachial plexus to inform such decisions. Therefore, the spinal cord and brachial plexus of 10 embalmed adult cadavers were exposed bilaterally by posterior dissection. Read More

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http://dx.doi.org/10.1111/joa.13270DOI Listing

Higher incidence of penetrating keratoplasty having effects on repeated keratoplasty in South Korea: A nationwide population-based study.

PLoS One 2020 6;15(7):e0235233. Epub 2020 Jul 6.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: To investigate the incidence of corneal transplantation and identify rates and risk factors of repeated corneal transplantation in South Korea.

Methods: This is a retrospective population-based cohort study using the Korean National Health Insurance System database. Among the entire South Korean population (N = 51,827,813), we included those who underwent corneal transplantation more than once between January 2006 and December 2016, and analyzed the annual incidence of keratoplasty. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235233PLOS

The perception of the stereo effect in bilateral and bimodal cochlear implant users and its contribution to music enjoyment.

PLoS One 2020 6;15(7):e0235435. Epub 2020 Jul 6.

Cluster of Excellence Hearing4all, Germany.

Objectives: In this clinical study, stereo perception of music samples and its contribution to music enjoyment in CI users is investigated. It is studied in free field as well as direct audio presentation.

Methods: 20 bilateral and 9 bimodal CI users performed stereo detection tests and music enjoyment ratings. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235435PLOS

GSMN-ML- a genome scale metabolic network reconstruction of the obligate human pathogen Mycobacterium leprae.

PLoS Negl Trop Dis 2020 Jul 6;14(7):e0007871. Epub 2020 Jul 6.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.

Leprosy, caused by Mycobacterium leprae, has plagued humanity for thousands of years and continues to cause morbidity, disability and stigmatization in two to three million people today. Although effective treatment is available, the disease incidence has remained approximately constant for decades so new approaches, such as vaccine or new drugs, are urgently needed for control. Research is however hampered by the pathogen's obligate intracellular lifestyle and the fact that it has never been grown in vitro. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007871DOI Listing

Emerging role of immunotherapy in locally advanced non-small cell lung cancer.

Clin Adv Hematol Oncol 2020 Apr;18(4):212-217

Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Non-small cell lung cancer (NSCLC) accounts for 85% of the cases of lung cancer in the United States, and 70% of patients with NSCLC have locally advanced or metastatic disease at the time of diagnosis. The 5-year overall survival rate for patients with locally advanced NSCLC is 15% to 20%. The traditional treatment paradigm for unresectable locally advanced NSCLC consists of platinum-based chemotherapy with concurrent radiation. Read More

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Scalp electroencephalography (sEEG) based advanced prediction of epileptic seizure time and identification of epileptogenic region.

Biomed Tech (Berl) 2020 Jul 5. Epub 2020 Jul 5.

Department of Applied Mechanics, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh, India.

Objectives Epilepsy is characterized by uncontrollable seizure during which consciousness of patient is disturbed. Prediction of the seizure in advance will increase the remedial possibilities for the patients suffering from epilepsy. An automated system for seizure prediction is important for seizure enactment, prevention of sudden unexpected deaths and to avoid seizure related injuries. Read More

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http://dx.doi.org/10.1515/bmt-2020-0044DOI Listing

Accurate Prediction of Coronary Heart Disease for Patients With Hypertension From Electronic Health Records With Big Data and Machine-Learning Methods: Model Development and Performance Evaluation.

JMIR Med Inform 2020 Jul 6;8(7):e17257. Epub 2020 Jul 6.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Background: Predictions of cardiovascular disease risks based on health records have long attracted broad research interests. Despite extensive efforts, the prediction accuracy has remained unsatisfactory. This raises the question as to whether the data insufficiency, statistical and machine-learning methods, or intrinsic noise have hindered the performance of previous approaches, and how these issues can be alleviated. Read More

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http://dx.doi.org/10.2196/17257DOI Listing

Technological Prospection of Oil Nanoparticles: Primary Characteristics and Profiles.

Recent Pat Nanotechnol 2020 Jul 5. Epub 2020 Jul 5.

Nutrition School, Federal University of Bahia, Salvador. Brazil.

Background: The search for technological applications for oils has been growing, largely due to their potential nutritional and economic applications. Encapsulation makes it possible to reduce the disadvantages of oils, such as physical instability or thermodynamics, or to improve their technological properties, enabling their use in various industrial areas. Nanoencapsulated oils have the potential to improve oil bioavailability and achieve controlled release and are able to target bioactive compounds with greater precision than microencapsulated oils. Read More

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http://dx.doi.org/10.2174/1872210514666200705234030DOI Listing

Prevalence and Factors Associated with Lower Limb Amputation in Patients Hospitalized for Diabetic Foot: a Cross-sectional Study.

Curr Diabetes Rev 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery and Surgical Specialties, Gaston Berger University of Saint-Louis. Senegal.

Background: Diabetes is the leading cause of non-traumatic amputation of the lower limb. Several factors associated with amputation are described in the literature, but they remain not well studied in our context.

Objectives: Our aim is to determine the prevalence and factors associated with amputation in patients hospitalized for diabetic foot. Read More

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http://dx.doi.org/10.2174/1573399816666200705205224DOI Listing

Genetic Counseling, Testing, and Management of HBOC in India: An Expert Consensus Document from Indian Society of Medical and Pediatric Oncology.

JCO Glob Oncol 2020 Jul;6:991-1008

Molecular Oncology and Cancer Genetics, Max Hospital, New Delhi, India.

Purpose: Hereditary breast and ovarian cancer (HBOC) syndrome is primarily characterized by mutations in the genes. There are several barriers to the implementation of genetic testing and counseling in India that may affect clinical decisions. These consensus recommendations were therefore convened as a collaborative effort to improve testing and management of HBOC in India. Read More

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http://dx.doi.org/10.1200/JGO.19.00381DOI Listing

Randomized, Parallel Group, Open-Label Bioequivalence Trial of Intramuscular Pegaspargase in Patients With Relapsed Acute Lymphoblastic Leukemia.

JCO Glob Oncol 2020 Jul;6:1009-1016

Homi Bhabha National Institute, Anushakthi Nagar, Mumbai, Maharashtra, India.

Purpose: Pegylated asparaginase is comparatively safer than native asparaginase in the management of acute lymphoblastic leukemia (ALL). However, the high price and nonavailability in low- and middle-income countries limits its use. In 2014, the first generic of pegaspargase (Hamsyl) was approved in India for use as a second-line treatment option for ALL. Read More

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http://dx.doi.org/10.1200/GO.20.00113DOI Listing

Development of Best Practices of Peer Review for Lung Radiation Therapy.

JCO Oncol Pract 2020 Jul 6:OP2000066. Epub 2020 Jul 6.

Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario, Canada.

Purpose: Peer review (PR) is an important component in ensuring high-quality lung radiotherapy (RT) plans. However, there are inconsistencies in the extent, timing, and minimum requirements for PR. We sought to develop guidelines of best practices for PR in curative lung RT through an expert consensus process. Read More

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http://dx.doi.org/10.1200/OP.20.00066DOI Listing

NEAR-FIELD THERMAL RADIATION BETWEEN TWO PLATES WITH SUB-10 NM VACUUM SEPARATION.

Nano Lett 2020 Jul 6. Epub 2020 Jul 6.

Radiation greatly exceeding blackbody between two objects separated by microscale distances has attracted great interest. However, challenges in reaching small separation between two plates have so far prevented studies below a separation distance of about 25 nm. Here, we report a study of radiation enhancement in the near-field regime of less than 10 nm between two parallel plates. Read More

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http://dx.doi.org/10.1021/acs.nanolett.0c02137DOI Listing

Topologically Nontrivial Phase-Change Compound GeSbTe.

ACS Nano 2020 Jul 6. Epub 2020 Jul 6.

Department of Physical Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.

Chalcogenide phase-change materials show strikingly contrasting optical and electrical properties, which has led to their extensive implementation in various memory devices. By performing spin-, time-, and angle-resolved photoemission spectroscopy combined with the first-principles calculation, we report the experimental results that the crystalline phase of GeSbTe is topologically nontrivial in the vicinity of the Dirac semimetal phase. The resulting linearly dispersive bulk Dirac-like bands that cross the Fermi level and are thus responsible for conductivity in the stable crystalline phase of GeSbTe can be viewed as a 3D analogue of graphene. Read More

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http://dx.doi.org/10.1021/acsnano.0c04145DOI Listing

On the Threshold Photoelectron Spectrum of Fulvenone, a Reactive Ketene Derivative in Lignin Valorization.

Chemphyschem 2020 Jul 6. Epub 2020 Jul 6.

Ben-Gurion University of the Negev, Chemistry, ISRAEL.

Unveiling reaction mechanisms by isomer-selective detection of reactive intermediates requires advanced spectroscopic knowledge. We study the photoionization of fulvenone (c-C 5 H 4 =C=O), a reactive ketene species relevant in catalytic pyrolysis of lignin, which was generated by pyrolysis of 2-methoxy acetophenone. The highresolution threshold photoelectron spectrum (TPES) with vacuum ultraviolet synchrotron radiation revealed well-resolved vibrational transitions, assigned to ring deformation modes of the cyclopentadienyl moiety. Read More

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http://dx.doi.org/10.1002/cphc.202000477DOI Listing
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