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J Assoc Physicians India 2022 May;70(5):11-12

Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu.

India shoulders a heavy burden of diabetes mellitus (DM), the management of which is suboptimal globally.& Objectives: Insulin Management: Practical Aspects in Choice of Therapy (IMPACT) survey was designed to gain insight into the ground (in-clinic) reality of DM management by physicians in India.

Methods: A survey consisting of 12 multiple-choice questions was conducted by SurveyMonkey® , focusing on practice profile, patient profile, and other aspects of DM management. Read More

Exp Physiol 2022 May 22. Epub 2022 May 22.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

New Findings: What is the central question of this study? Does the AGEs-RAGE axis mediate myocardial fibrosis in heart failure? What is the main finding and its importance? The AGEs-RAGE axis is involved in the pathogenesis of myocardial fibrosis through CFs activation induced by autophagy in heart failure. Inhibiting AGEs-RAGE axis attenuates dysfunction in the heart and attenuates myocardial fibrosis in mice with TAC via suppressing CFs activation.

Abstract: Background: Heart failure is the end stage of cardiovascular diseases, and is a critical medical condition that poses an important therapeutic challenge for physicians due to its high morbidity and mortality. Read More

Macromol Biosci 2022 May 21:e2200019. Epub 2022 May 21.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.

Wound healing in diabetes is retarded by the dysfunctional local microenvironment. Although there are many studies using hydrogels as substitutes for natural extracellular matrices (ECMs), hydrogels that can mimic both the structure and functions of natural ECM remain a challenge. Self-assembling peptide RADA16 nanofiber has distinct advantageous to provide a biomimetic extracellular matrix nanofiber structure. Read More

Stem Cell Res Ther 2022 May 21;13(1):209. Epub 2022 May 21.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Background: The metabolic phenotype of stem cells is increasingly recognized as a hallmark of their pluripotency with mitochondrial and oxygen-related metabolism playing a not completely defined role in this context. In a previous study, we reported the ectopic expression of myoglobin (MB) in bone marrow-derived hematopoietic stem/progenitor cells. Here, we have extended the analysis to mesenchymal stem cells (MSCs) isolated from different tissues. Read More

Virol J 2022 May 21;19(1):87. Epub 2022 May 21.

Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: The new coronavirus (COVID-19) has been transmitted exponentially. Numerous studies have been performed in recent years that have shown the inhibitory effect of plant extracts or plant-derived compounds on the coronavirus family. In this study, we want to use systematic review and meta-analysis to answer the question, which herbal compound has been more effective?

Main Body: The present study is based on the guidelines for conducting meta-analyzes. Read More

Respir Res 2022 May 21;23(1):129. Epub 2022 May 21.

Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Recombinant human pentraxin-2 (rhPTX-2) significantly decreased decline in percent predicted forced vital capacity (FVC) and stabilized 6-min walk distance (6MWD) in patients with idiopathic pulmonary fibrosis (IPF) during the 28-week, placebo-controlled, randomized period of the Phase II PRM-151-202 study. Interim (76-week) data from the open-label extension (OLE) demonstrated sustained safety and efficacy with rhPTX-2 treatment. Here, we present the entire long-term OLE safety and efficacy data to 128 weeks. Read More

Radiat Oncol 2022 May 21;17(1):100. Epub 2022 May 21.

Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: We investigated the prognostic impact of the neutrophil-to-lymphocyte ratio (NLR) in patients with locally advanced rectal cancer (LARC) and whether modifiable factors in radiotherapy (RT) influenced the NLR.

Methods: Data of 1386 patients who were treated with neoadjuvant RT and concurrent or sequential chemotherapy for LARC between 2006 and 2019 were evaluated. Most patients (97. Read More

BMC Public Health 2022 May 21;22(1):1022. Epub 2022 May 21.

British Columbia Centre for Excellence in HIV/AIDS, 608-1081 Burrard Street, Vancouver, BC, V6Z1Y6, Canada.

Introduction: In 2010, the Canadian province of British Columbia (BC) initiated the Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) program to improve HIV testing, linkage to care, and treatment uptake, thereby operationalizing the HIV Treatment as Prevention (TasP) framework at the population-level. In this analysis, we evaluated self-reported HIV care experiences and therapeutic outcomes among people diagnosed with HIV prior to and after implementation of this provincial program.

Methods: A cross-sectional analysis was performed on the baseline data of a cohort of people living with HIV (PLWH) (19 years and older) in the province of BC sampled from July 2016 to September 2018. Read More

ISME J 2022 May 21. Epub 2022 May 21.

CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Dietary fibers are generally thought to benefit intestinal health. Their impacts on the composition and metabolic function of the gut microbiome, however, vary greatly across individuals. Previous research showed that each individual's response to fibers depends on their baseline gut microbiome, but the ecology driving microbiota remodeling during fiber intake remained unclear. Read More

Br J Cancer 2022 May 21. Epub 2022 May 21.

Department of General, Visceral and Pediatric Surgery, University Medical Center, Göttingen, Germany.

Purpose: Preoperative (neoadjuvant) chemoradiotherapy (CRT) and total mesorectal excision is the standard treatment for rectal cancer patients (UICC stage II/III). Up to one-third of patients treated with CRT achieve a pathological complete response (pCR). These patients could be spared from surgery and its associated morbidity and mortality, and assigned to a "watch and wait" strategy. Read More

J Assist Reprod Genet 2022 May 21. Epub 2022 May 21.

Department of Obstetrics and Gynecology, Saitama Medical University, 38, Morohongo, Moroyama, Saitama, 350-0495, Japan.

Purpose: The use of assisted reproductive technology (ART) and prenatal genetic testing have become more widespread in line with an increase in maternal age. However, the effect of the introduction of non-invasive prenatal testing (NIPT) in April 2013 on pregnancy outcomes in Japan, including the prevalence of Down syndrome live births following ART, has not been investigated. This study aimed to evaluate the trends in the prevalence of Down syndrome live births following ART in Japan. Read More

Ann Surg Oncol 2022 May 21. Epub 2022 May 21.

Department of Surgical Oncology, The University of Texas at MD Anderson Cancer Center, Houston, TX, USA.

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon peripheral T cell lymphoma arising in response to textured-surface breast implants. Frequently, BIA-ALCL is indolent and typically presents with peri-implant swelling after breast reconstruction or cosmetic augmentation. However, patients can present with an invasive breast or chest wall mass, palpable lymphadenopathy, or metastatic disease. Read More

Breast Cancer Res Treat 2022 May 21. Epub 2022 May 21.

Department of Molecular Oncology, Cancer Institute WIA, Chennai, 600036, Tamil Nadu, India.

Background: Therapeutic response predictors like age, nodal status, and tumor grade and markers, like ER/PR, HER2, and Ki67, are not reliable in predicting the response to a specific form of chemotherapy. The current study aims to identify and validate reliable markers that can predict pathological complete response (pCR) in fluorouracil, epirubicin, and cyclophosphamide (FEC)-based neoadjuvant therapy with (NACT/RT) and without concurrent radiation (NACT).

Materials And Methods: Tandem mass tag (TMT) quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to identify differentially expressed proteins from core needle breast biopsy between pCR (n = 4) and no-pCR (n = 4). Read More

World J Microbiol Biotechnol 2022 May 22;38(7):117. Epub 2022 May 22.

International Clean Water Institute, Manassas, VA, USA.

Microplastics are one of the major contaminants of aquatic nature where they can interact with organic and inorganic pollutants, including trace metals, and adsorb them. At the same time, after the microplastics have entered the aquatic environments, they are quickly covered with a biofilm - microorganisms which are able to produce extracellular polymeric substances (EPS) that can facilitate sorption of trace metals from surrounding water. The microbial community of biofilm contains bacteria which synthesizes EPS with antimicrobial activity making them more competitive than other microbial inhabitants. Read More

J Geriatr Oncol 2022 May 18. Epub 2022 May 18.

Moffitt Cancer Center, Florida, USA.

Introduction: Pancreatic ductal adenocarcinoma (PDAC) mainly occurs in older adults. Since randomized clinical trials (RCTs) provide the highest-quality evidence incorporated in NCCN recommendations, the underrepresentation of older patients in RCTs challenges guidelines' external validity and limits the solidity of evidence in this specific population.

Materials And Methods: The study aimed to investigate external validity of NCCN guidelines for PDCA and the impact of reference studies eligibility on overall survival (OS) in a real-world older population. Read More

J Biosci Bioeng 2022 May 18. Epub 2022 May 18.

Graduate School of Advanced Technology and Science, Tokushima University, 2-1 Minamijosanjima-cho, Tokushima 770-8513, Japan; Graduate School of Technology, Industrial and Social Sciences, Tokushima University, 2-1 Minamijosanjima-cho, Tokushima 770-8513, Japan. Electronic address:

Quantification of leuco-indigo is most important for Aizome, Japanese indigo-dyeing; however, there has been no convenient quantitative method. This study demonstrated that normal pulse voltammetry under quiescent conditions can be used to detect leuco-indigo. As a result of quantification of leuco-indigo in the depth direction in fermenting suspensions, the steady-state concentrations of leuco-indigo showed sigmoidal profiles in the depth direction. Read More

Cardiovasc Revasc Med 2022 May 13. Epub 2022 May 13.

Department of Cardiovascular Medicine, National Cerebral & Cardiovascular Center, 6-1, Kishibe-shimmachi, Suita, Osaka 564-8565, Japan; Department of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

Background: The distal radial approach (DRA) is a novel catheter cannulation technique to access the distal radial artery for coronary angiography (CAG). It is associated with less occurrence of puncture site occlusion than the conventional transradial approach. However, cannulation failure occasionally occurs due to difficulty in puncturing the smaller distal radial artery. Read More

Trends Biochem Sci 2022 May 18. Epub 2022 May 18.

Chemistry Department, Universidad Autónoma de Madrid, 28049, Madrid, Spain; IADCHEM, Institute for Advanced Research in Chemistry, Universidad Autónoma de Madrid, 28049, Madrid, Spain. Electronic address:

Mous et al. recently reported the molecular mechanism of chloride transport through a light-activated pumping rhodopsin, a key process involved in a range of cellular functions. Their results open exciting new challenges for photopharmacology and computational modeling that should be addressed in the coming years. Read More

Int J Oral Maxillofac Surg 2022 May 18. Epub 2022 May 18.

Division of Maxillofacial Surgery, City of Health and Science of Turin Hospital, University of Turin, Turin, Italy.

The aim of this systematic review and meta-analysis was to analyse the literature on the infrahyoid myocutaneous flap (IHMCF) and evaluate its clinical outcomes. The MEDLINE, Embase, Web of Science, Cochrane Library, and Scopus databases were searched (inception to December 31, 2021). Meta-analyses were then conducted to estimate the overall rates of partial flap loss, total flap loss, salivary fistula, and surgical revision. Read More

J Chem Phys 2022 May;156(19):194111

International School for Advanced Studies (SISSA), Via Bonomea 265, 34136 Trieste, Italy.

The effect of atomic relaxations on the temperature-dependent elastic constants (TDECs) is usually taken into account at zero temperature by the minimization of the total energy at each strain. In this paper, we investigate the order of magnitude of this approximation on a paradigmatic example: the C elastic constant of diamond and zincblende materials. We estimate the effect of finite-temperature atomic relaxations within the quasi-harmonic approximation by computing ab initio the internal strain tensor from the second derivatives of the Helmholtz free-energy with respect to strain and atomic displacements. Read More

J Chem Phys 2022 May;156(19):194901

Theoretical Physics of Living Matter, Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum Jülich, 52425 Jülich, Germany.

The properties of microswimmer dumbbells composed of pusher-puller pairs are investigated by mesoscale hydrodynamic simulations employing the multiparticle collision dynamics approach for the fluid. An individual microswimmer is represented by a squirmer, and various active-stress combinations in a dumbbell are considered. The squirmers are connected by a bond, which does not impose any geometrical restriction on the individual rotational motion. Read More

J Chem Phys 2022 May;156(19):194303

Departamento de Química, Módulo 13, Facultad de Ciencias and Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, Madrid 28049, Spain.

Although triazoles and tetrazole are amphoteric and may behave as weak acids, the latter property can be hugely enhanced by beryllium bonds. To explain this phenomenon, the structure and bonding characteristics of the complexes between triazoles and tetrazoles with one and two molecules of BeF have been investigated through the use of high-level G4 ab initio calculations. The formation of the complexes between the N basic sites of the azoles and the Be center of the BeF molecule and the (BeF) dimer leads to a significant bonding perturbation of both interacting subunits. Read More

Bull Cancer 2022 May 18. Epub 2022 May 18.

Oncology Department, Portuguese Institute of Oncology Francisco Gentil, Rua Dr. António Bernardino de Almeida 865, 4200-072 Porto, Portugal.

ISA Trans 2022 May 9. Epub 2022 May 9.

Key Laboratory of Advanced Transducers and Intelligent Control System, Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China.

In the single-excitation-motor inertial flip-flow screen, the vibration phase difference is difficult to maintain at the ideal angle of 180° for two screen frames, which results in the low screening efficiency. To solve this problem, a flip-flow screen driven by double excitation motors is established, together with its control system. The vibration phase difference for two screen frames can reach 180° when the phase difference for two eccentric blocks is 170° based on the experimental model. Read More

Gene 2022 May 18:146586. Epub 2022 May 18.

Department of Medical Biotechnology, Molecular and Cell Biology Research Center, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

The use of umbilical cord-derived mesenchymal stem cells along with three-dimensional (3D) scaffolds in pancreatic tissue engineering can be considered as a treatment for diabetes. This study aimed to investigate the differentiation of Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) into pancreatic islet-insulin producing cells (IPCs) on silk/gelatin nanofibers as a 3D scaffold. Mesenchymal markers were evaluated at the mesenchymal stem cells (MSCs) level by flowcytometry. Read More

Gene 2022 May 18:146581. Epub 2022 May 18.

Department of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, C.P. 07360 Mexico City, Mexico. Electronic address:

The assembly of transcription complexes on eukaryotic promoters involves a series of steps, including chromatin remodeling, recruitment of TATA-binding protein (TBP)-containing complexes, the RNA polymerase II holoenzyme, and additional basal transcription factors. This review describes the transcriptional regulation by TBP and its corresponding homologs that constitute the TBP family and their interactions with promoter DNA. The C-terminal core domain of TBP is highly conserved and contains two structural repeats that fold into a saddle-like structure, essential for the interaction with the TATA-box on DNA. Read More

Drug Discov Today 2022 May 18. Epub 2022 May 18.

Advanced Computation and Data Sciences Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, 785006, India.

A typical drug discovery project involves identifying active compounds with significant binding potential for selected disease-specific targets. Experimental high-throughput screening (HTS) is a traditional approach to drug discovery, but is expensive and time-consuming when dealing with huge chemical libraries with billions of compounds. The search space can be narrowed down with the use of reliable computational screening approaches. Read More

Chemosphere 2022 May 18:134995. Epub 2022 May 18.

School of Environmental & Safety Engineering, Changzhou University, Changzhou, 213164, China.

Mono-to octa-chlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in pooled blood from the general population living near a typical industrialized area were investigated. Less chlorinated PCDD/Fs (mean: 2602 pg L) were 7.5 times those of highly chlorinated ones (mean: 349 pg L). Read More

Semin Cancer Biol 2022 May 18. Epub 2022 May 18.

Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, CA, USA. Electronic address:

Prostate cancer is the most common non-cutaneous cancer and the second leading cause of cancer-associated deaths among men in the United States. Androgen deprivation therapy (ADT) is the standard of care for advanced prostate cancer. While patients with advanced prostate cancer initially respond to ADT, the disease frequently progresses to a lethal metastatic form, defined as castration-resistant prostate cancer (CRPC). Read More

Int J Surg 2022 May 18:106682. Epub 2022 May 18.

Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Izatnagar, Uttar Pradesh, 243122, India. Electronic address: