Search Our Scientific Publications & Authors

Psychogeriatrics 2021 May 4. Epub 2021 May 4.

National Centre for Geriatrics and Gerontology, Obu, Japan.

Background: This study aims to reconsider diagnostic approaches to dementia where pharmacological approaches are not available to reverse the pathological changes caused by dementia.

Methods: A questionnaire survey was conducted with 524 physicians specialising in dementia management in Aichi, Japan, with 163 (31.1%) valid responses. Read More

Z Orthop Unfall 2021 May 4. Epub 2021 May 4.

Klinik für Rehabilitationsmedizin, Medizinische Hochschule Hannover, Hannover, Germany.

Background: Before foreign language questionnaires, such as patient reported outcome measures (PROMs), can be scientifically used in the national language, guideline-based translation, cultural adaptation and comprehensive verification of their validity and reliability are needed. The aim of this study was to assess the psychometric properties of the German version of the LCI-5 (LCI-5-D) on a sample of people with lower limb amputation (LLA).

Methods: The LCI-5 was translated into German (LCI-5-D) based on the ISPOR guidelines for cross-cultural adaptation following pilot testing. Read More

J Knee Surg 2021 May 4. Epub 2021 May 4.

Center for Joint Preservation and Replacement, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland.

To our knowledge, no studies have compared postoperative outcomes between patients who received a temporary short or long intramedullary (IM) nail in the setting of infected total knee arthroplasty (TKA). Therefore, the aim of this study was to compare short-term outcomes for patients who underwent long or short IM nail insertion for treatment of periprosthetic knee infection. Specifically, we compared: (1) success rates; (2) patient reported/functional outcomes; and (3) complications between patients implanted with a short or a long IM nail following PJI of the knee. Read More

Tex Heart Inst J 2021 Jan;48(1)

Department of Advanced Cardiopulmonary Therapies and Transplantation, University of Texas Health Science Center at Houston, Houston, Texas.

Continuous-flow left ventricular assist device implantation is the typical treatment for end-stage heart failure. Improvements in device engineering and technology, surgical experience and technique, and perioperative management have advanced the field, and short-term results approach those of heart transplantation. Further improvements may be achieved by minimizing adverse physiologic effects associated with cardiopulmonary bypass. Read More

Arch Pathol Lab Med 2021 May 4. Epub 2021 May 4.

From the Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Context.—: Inflammatory polyps (IPs) in inflammatory bowel disease may have been associated in the past with increased neoplasia risk. Additionally, colonic mucosa in filiform polyposis and giant inflammatory polyposis may be difficult to visualize during endoscopic surveillance, perhaps contributing to early colectomy in these patients. Read More

Aging (Albany NY) 2021 May 3;13. Epub 2021 May 3.

Department of General Surgery III, Affiliated Hospital of Shaoxing University, Zhejiang 312000, China.

Fibroblasts are a highly heterogeneous population in tumor microenvironment. PDGFR-β fibroblasts, a subpopulation of activated fibroblasts, have proven to correlate with cancer progression through multiple of mechanisms including inducing angiogenesis and immune evasion. However, the prognostic role of these cells in solid tumors is still not conclusive. Read More

Aging (Albany NY) 2021 May 3;13. Epub 2021 May 3.

Toxicology and Functional Laboratory, Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, China.

Immune checkpoint inhibitors (ICI) prolong the survival for advanced/metastatic patients with lung cancer or melanoma; however, for hepatocellular carcinoma (HCC) patients, a durable response has not been reported. Herein, we used a total of 719 HCC patients with public genomic data to determine potential prognostic and immunogenic subtypes. The non-negative matrix factorization (NMF) method was applied to identify the immune classes and potential subtypes. Read More

Cancer Epidemiol 2021 May 1;72:101942. Epub 2021 May 1.

Program of Epidemiology, College of Health Sciences, University of Delaware, 100 Discovery Blvd, Newark, DE, 19713, United States.

Brain tumors, a group of heterogeneous diseases, are the second most common cancer and the leading cause of cancer-related deaths in children. Insight into the prognosis of pediatric brain tumor survival has led to improved outcomes and could be further advanced through precision in prognosis. We analyzed the United States SEER population-based dataset of 15,723 pediatric brain tumor patients diagnosed and followed between 1975 and 2016 using a stratified Cox proportional hazards model. Read More

J Colloid Interface Sci 2021 Apr 20;599:227-244. Epub 2021 Apr 20.

Department of Chemistry, Faculty of Science, Sohag University, 82524 Sohag, Egypt. Electronic address:

The current study provides a novel insight into the role of synergism of the changes in Mg/ Al in the best catalytic activity of indol-3-yl derivatives. A series of Co-Mg-Al layered triple hydroxides (LTHs) catalysts were produced by altering the Al/Mg ratio with respect to Co. The physicochemical properties of LTHs were well characterized by ICP-AES, XRD, FTIR, FE-SEM, BET, Zeta-sizer, and VSM. Read More

J Colloid Interface Sci 2021 Apr 20;599:219-226. Epub 2021 Apr 20.

College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China. Electronic address:

Stable and recyclable catalysts are crucial to the peroxymonosulfate (PMS) based advanced oxidation process (AOPs) for wastewater treatment. Herein, nitrogen-rich carbon wrapped FeC (FeC@CN) on carbon felt (CF) substrate was synthesized by using Prussian blue (PB) loaded CF as the precursors. The obtained FeC@CN/CF catalyst was applied for degradation of bisphenol A (BPA) via the heterogeneous catalytic activation of PMS. Read More

Waste Manag 2021 May 1;127:179-188. Epub 2021 May 1.

State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing, Beijing 100083, China.

More than 1.2 million tons of tailings containing approximately 30 wt% of Fe from traditional vanadium extraction processes are discarded every year as solid waste, which waste resources. In order to achieve effective and green utilization of waste, a novel process was proposed to keep Cr and V at Cr and V during extraction by using AlCl-NaCl-KCl molten salt in Ar gas atmosphere to control the valuable elements (Cr, V, Mn and Fe) from oxidized. Read More

J Affect Disord 2021 Apr 16;289:66-73. Epub 2021 Apr 16.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Francesco Sforza 28, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milan, Via Francesco Sforza 35, 20122 Milano, Italy.

Background: Psychopathological symptoms during euthymia in Bipolar Disorder (BD) affect quality of life and predispose to the occurrence of new acute episodes, however only few studies investigated potential risk-factors. This study aims to explore the association between childhood trauma (CT), lifetime stressful events (SLEs) and psychopathological symptoms in BD patients during euthymia and controls (HC).

Methods: A total of 261 participants (93 euthymic patients with BD, 168 HC) were enrolled. Read More

Biomed Pharmacother 2021 May 1;139:111643. Epub 2021 May 1.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Molecular Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Tumor angiogenesis plays a vital role in tumor growth and metastasis. It is proven that in tumor vasculature, endothelial cells (ECs) originate from a small population of cancer cells introduced as cancer stem cells (CSCs). Autophagy has a vital role in ECs differentiation from CSCs and tumor angiogenesis. Read More

Contemp Clin Trials 2021 May 1:106405. Epub 2021 May 1.

Department of Neurology and Neurosurgery, McGill University, CA, USA; Brigham and Women's Hospital, Harvard Medical School, USA.

Sedentary behavior increases the risk for multiple chronic diseases, early mortality, and accelerated cognitive decline in older adults. Interventions to reduce sedentary behavior among older adults are needed to improve health outcomes and reduce the burden on healthcare systems. We designed a randomized controlled trial that uses a self-affirmation manipulation and gain-framed health messaging to effectively reduce sedentary behavior in older adults. Read More

Acta Biomater 2021 May 1. Epub 2021 May 1.

Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland. Electronic address:

In cases of aortic stenosis, bioprosthetic heart valves (BHVs), with glutaraldehyde-fixed bovine pericardium leaflets (GLBP), are often implanted to replace the native diseased valve. Widespread use of BHVs, however, is restricted due to inadequate long-term durability, owing specifically to premature leaflet failure. Mechanical fatigue damage and calcification remain the primary leaflet failure modes, where glutaraldehyde treatment is known to accelerate calcification. Read More

Biochim Biophys Acta Rev Cancer 2021 May 1:188554. Epub 2021 May 1.

Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is characterized by early metastasis, low resectability, high recurrence, and therapy resistance. The experimental mouse models have played a central role in understanding the pathobiology of PDAC and in the preclinical evaluation of various therapeutic modalities. Different mouse models with targetable pathological hallmarks have been developed and employed to address the unique challenges associated with PDAC progression, metastasis, and stromal heterogeneity. Read More

Int J Cardiol 2021 May 1. Epub 2021 May 1.

Advanced Heart Failure & Pulmonary Hypertension Programs, Section of Heart Failure/Transplant/MCS & Pulmonary Hypertension, Echocardiography Staff, Allegheny General Hospital, Associate Professor of Medicine, Drexel University College of Medicine, 320 East North Avenue, Pittsburgh, PA 15212-4772, United States. Electronic address:

ACS Appl Mater Interfaces 2021 May 4. Epub 2021 May 4.

Faculty of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

The emergence of bacteria resistant to antibiotics and the resulting infections are increasingly becoming a public health issue. Multidrug-resistant (MDR) bacteria are responsible for infections leading to increased morbidity and mortality in hospitals, prolonged time of hospitalization, and additional burden to financial costs. Therefore, there is an urgent need for novel antibacterial agents that will both treat MDR infections and outsmart the bacterial evolutionary mechanisms, preventing further resistance development. Read More

Cell Biol Int 2021 May 4. Epub 2021 May 4.

Department of Shanghai Lung Cancer center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 200030, Shanghai, China.

Background: Patient-derived xenograft (PDX) assay has been widely used in preclinical researches in patients with multidrug-resistant lung cancer.

Methods: 100 patients with non-small cell lung cancer (NSCLC) were divided into MiniPDX group and conventional group, with 50 cases in each group. The MiniPDX assay was established by enriching high-purity tumor cells using microfluidic technology to detect the drug sensitivity of NSCLC cells. Read More

Ophthalmic Physiol Opt 2021 May 4. Epub 2021 May 4.

Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain.

Purpose: To estimate the prevalence of computer vision syndrome (CVS) in presbyopic digital device workers using two ophthalmic progressive lens designs during the working day, and to analyse the association of CVS with sociodemographic, occupational, digital device exposure and refractive factors.

Methods: This time series, quasi-experimental design study included 69 presbyopic digital device workers (age range: 46-69 years; mean ± SD = 54.7 ± 5. Read More

J Oral Implantol 2021 May 4. Epub 2021 May 4.

Associate Professor, Phillip Maurer Tennis Professor of Clinical Dentistry, Assistant Director of Advanced Prosthodontics, Director of Predoctoral Implant Dentistry, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, Califor.

Subcrestal placement of implants may have interproximal bone proximity issues that interfere with submucosal contour of the implant-supported Zirconia restorations during delivery of these restorations.  Modification of the mesial distal submucosal areas may be necessary to fully seat the restoration without impingement of the interproximal bone. Our aim was to determine if modification of submucosal cervical contour of implant supported zirconia titanium base (Zi-Ti base) restorations result in a significant change in fracture strength compared to Zi-Ti base restorations without any modification near the cervical submucosal area. Read More

PLoS One 2021 4;16(5):e0250985. Epub 2021 May 4.

Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Amhara, Ethiopia.

Background: Sleep is a physiologic necessity for all humankind. Pregnant women, in particular, need adequate sleep to develop their fetuses as well as save energy required for delivery. A change in sleep quality and quantity is the most common phenomena during pregnancy due to mechanical and hormonal factors. Read More

PLoS One 2021 4;16(5):e0251042. Epub 2021 May 4.

Faculty of Medicine, Department of Internal Medicine, Gastroenterology Unit, Thammasat University, Pathumthani, Thailand.

Background: Helicobacter pylori (HP) is a bacterium associated with many gastrointestinal (GI) diseases and has shown a high prevalence in Parkinson's disease (PD). As HP-associated GI dysfunction could affect L-dopa (levodopa) absorption, HP eradication might improve the clinical response and decrease motor fluctuations.

Methods: A prospective cohort study was conducted on the clinical symptoms of PD patients with motor fluctuations. Read More

PLoS One 2021 4;16(5):e0250072. Epub 2021 May 4.

Division of Lower GI Surgery, Department of Surgery, Hyogo College of Medicine, Hyogo, Japan.

Circulating microRNAs (miRNAs) are considered promising biomarkers for diagnosis, prognosis, and treatment efficacy of diseases. However, usefulness of circulating miRNAs as biomarkers for hereditary gastrointestinal diseases have not been confirmed yet. We explored circulating miRNAs specific for patients with familial adenomatous polyposis (FAP) as a representative hereditary gastrointestinal disease. Read More

J Clin Invest 2021 May 4. Epub 2021 May 4.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, United States of America.

Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achieves a durable remission. SIRT5 is a member of the sirtuin family of protein deacylases that regulate metabolism and other biological processes. Read More

Elife 2021 May 4;10. Epub 2021 May 4.

Optobiology, Humboldt-Universität zu Berlin, Institute of Biology, Berlin, Germany.

Members of the SH3- and ankyrin-rich repeat (SHANK) protein family are considered as master scaffolds of the post-synaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as causative for the development of autism spectrum disorders (ASDs). However, there is a surprising paucity of data linking missense mutation-induced changes in protein structure and dynamics to the occurrence of ASD-related synaptic phenotypes. Read More

Autophagy 2021 May 4:1-3. Epub 2021 May 4.

Department of Cell Death and Proliferation, Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Mitochondrial dysfunction is behind several neurodegenerative diseases, including Alzheimer disease (AD). Accumulation of damaged mitochondria is already observed at the early stages of AD and has been linked to impaired mitophagy, but the mechanisms underlying this alteration are still not fully known. In our recent study, we show that intracellular cholesterol enrichment can downregulate amyloid beta (Aβ)-induced mitophagy. Read More

Expert Opin Ther Targets 2021 May 4. Epub 2021 May 4.

Division of Medical Oncology, Department of Medicine, Montefiore Hospital and Medical Center, Bronx, NY, USA 10467-2490.

IntroductionThe gene and its pathway normally plays a crucial role in cell homeostasis, motility, and apoptosis. However, when the gene is altered, there is an imbalance towards cell proliferation and invasion commonly seen in numerous different types of cancers. The heterogeneous group of alterations that includes amplification, exon 14 skipping mutation, and fusions has been difficult to diagnose and treat. Read More

Expert Opin Investig Drugs 2021 May 4. Epub 2021 May 4.

Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Introduction: Von Hippel-Lindau (VHL) disease is an inherited autosomal dominant syndrome caused by a germline mutation and/or deletion of the gene. Inappropriate hypoxia inducible factor (HIF) meditated transcription of proangiogenic and metabolic genes leads to the development of tumors and cysts in multiple organs. Surgery is a standard treatment for localized tumors with a risk of metastasis or organ dysfunction. Read More

Environ Health Perspect 2021 May 4;129(5):57701. Epub 2021 May 4.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China.