602 results match your criteria Advanced Studies in Medicine [Journal]


Upregulation of lncRNA SNHG1 is associated with metastasis and poor prognosis in cancers: A meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15196

Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University.

Background: Accumulating evidence suggested that the expression level of long noncoding RNA small nucleolar RNA host gene 1 (lncRNA SNHG1) was upregulated in various cancers, and high expression of SNHG1 was associated with metastasis and prognosis in patients with cancer.The relationship between SNHG1 expression and metastasis or prognosis in malignant tumors was investigated in this meta-analysis.

Methods: A systematic search was performed in PubMed, Web of Science, and Cochrane Library from inception until May 31, 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000015196DOI Listing

Risk factors of malignant fluorodeoxyglucose-avid lymph node on preablation positron emission tomography in patients with papillary thyroid cancer undergoing radioiodine ablation therapy.

Medicine (Baltimore) 2019 Apr;98(16):e14858

Department of Nuclear Medicine, Chonnam National University Hospital.

F-18 fluorodeoxyglucose (FDG)-avid metastatic lesions are associated with a poor response to radioiodine ablation therapy (RIT) in papillary thyroid cancer (PTC). This study evaluated the significance of preablative FDG positron emission tomography (PET) for the assessment of risk factors and frequency of malignant FDG-avid lymph nodes in patients with PTC undergoing RIT.The study included 339 consecutive patients (mean age 46. Read More

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http://dx.doi.org/10.1097/MD.0000000000014858DOI Listing
April 2019
1 Read

Protocol for a systematic review and meta-analysis of the efficacy of acupuncture and electroacupuncture against chemotherapy-induced peripheral neuropathy.

Medicine (Baltimore) 2019 Apr;98(14):e15098

Institute for Integrative Medicine, Catholic Kwandong University International St. Mary's Hospital, Incheon.

Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) occurs in approximately 30% to 40% of patients who receive chemotherapy; however, standardized treatment for CIPN has not yet been developed. Acupuncture is widely used to treat CIPN in Korea, but its efficacy has not been investigated. The purpose of this study is to review the current literature on the efficacy of acupuncture and electroacupuncture (EA) in treating CIPN. Read More

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http://dx.doi.org/10.1097/MD.0000000000015098DOI Listing
April 2019
2 Reads

Diagnostic accuracy of red blood cell distribution width to platelet ratio for predicting staging liver fibrosis in chronic liver disease patients: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Apr;98(14):e15096

Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University.

Background: Red cell volume distribution width to platelet ratio (RPR), as a novel noninvasive assessment, is frequently investigated. However, the utility of RPR to evaluate the diagnostic accuracy of liver fibrosis remains controversial. We performed a meta-analysis to determine the diagnostic performance of RPR for detecting staging liver fibrosis in patients with chronic liver disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000015096DOI Listing
April 2019
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CT findings and clinical features of Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma.

Medicine (Baltimore) 2019 Apr;98(14):e14839

Department of Pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Epstein-Barr virus (EBV)-associated lymphoepithelioma-like gastric carcinoma (LELGC) is a rare primary stomach tumor, which has overlapping imaging features with mass forming gastric carcinoma (GC). The aim of our study was to present the computed tomography (CT) findings and clinical features of EBV-associated LELGC to increase awareness of this entity.The CT findings and clinical features of 4 patients with pathologically documented EBV-associated LELGC were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014839DOI Listing
April 2019
2 Reads

Prognostic values of 18F-FDG PET/CT metabolic parameters and clinical figures in locally advanced pancreatic cancer underwent chemotherapy combined with stereotactic body radiation therapy.

Medicine (Baltimore) 2019 Mar;98(13):e15064

Department of Nuclear Medicine.

Stereotactic body radiation therapy (SBRT) has emerged to be a preference treatment for locally advanced pancreatic cancer (LAPC) patients. In this study, we aimed to investigate the prognostic roles of F-FDG PET/CT metabolic parameters and clinical figures in LAPC patients underwent chemo-SBRT combined therapy.During January 2013 to January 2017, 23 LAPC patients who underwent F-FDG PET/CT within 2 weeks before treatment were recruited and retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000015064DOI Listing
March 2019
1 Read

Specialist palliative care support is associated with improved pain relief at home during the last 3 months of life in patients with advanced disease: analysis of 5-year data from the national survey of bereaved people (VOICES).

BMC Med 2019 Mar 22;17(1):50. Epub 2019 Mar 22.

Academic Unit of Palliative Care, Leeds Institute of Health Sciences (LIHS), School of Medicine, University of Leeds, Room 10.39, Level 10, Worsley Building, Clarendon Way, Leeds, LS2 9NL, UK.

Background: Studies have shown that more than half of patients with advanced progressive diseases approaching the end-of-life report pain and that pain relief for these patients is poorest at home compared to other care settings such as acute care facilities and hospice. Although home is the most common preferred place of death, the majority of deaths occur outside the home. Specialist palliative care is associated with improved quality of life, but systematic reviews of RCTs have failed to show a consistent association with better pain relief. Read More

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http://dx.doi.org/10.1186/s12916-019-1287-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429790PMC

Sentinel node biospy using intravital blue dye: An useful technique for identification of skip metastases in gastric cancer.

Medicine (Baltimore) 2019 Mar;98(12):e14951

Department of Surgery.

As the lymph node status remains the main prognostic factor of gastric cancer (GC), several lymph node-based staging systems have been recently proposed for an appropriate postoperative therapy. The identification of sentinel lymph nodes (SLNs) might improve the postoperative protocols. The aim of this study was to present our experience in detecting SLNs in GC using methylene blue dye. Read More

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http://dx.doi.org/10.1097/MD.0000000000014951DOI Listing
March 2019
1 Read

Serum YKL-40 predicts long-term outcome in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.

Medicine (Baltimore) 2019 Mar;98(12):e14920

Department of Intensive Care Unit.

Serum YKL-40, a potential inflammatory marker, is greatly increased at the early stage of ST-segment elevation myocardial infarction (STEMI). Here, we hypothesized that YKL-40 levels at admission could predict the long-term outcomes after STEMI.A total of 324 patients with acute STEMI undergoing primary percutaneous coronary intervention (PCI) were consecutively enrolled and followed for 24 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000014920DOI Listing
March 2019
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The clinicopathologic of pulmonary adenocarcinoma transformation to small cell lung cancer.

Medicine (Baltimore) 2019 Mar;98(12):e14893

Department of Lung Cancer and Gastroenterology.

Transformation to small cell lung cancer (SCLC) is one of the mechanisms of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, it is uncertain how it works and there is no standard treatment after the transformation. In this study, 7 patients with transformation of SCLC from advanced lung adenocarcinoma (ADC) were analyzed retrospectively and the clinical pathology, imaging characteristics and treatment were analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014893DOI Listing

Interproximal caries and premature tooth loss in primary dentition as risk factors for loss of space in the posterior sector: A cross-sectional study.

Medicine (Baltimore) 2019 Mar;98(11):e14875

Advanced Studies and Research Center in Dentistry, "Dr Keisaburo Miyata" Faculty of Dentistry at Autonomous University of State of Mexico, Toluca.

Dental caries-a highly prevalent public health problem in preschoolers and school children-is the main cause of premature dental loss during childhood, and this may be related to loss of space in the posterior sector. The objective of this study was to evaluate whether interproximal caries and premature tooth loss (D and/or E) are risk factors for loss of space in the posterior sector.A comparative cross-sectional study (split-mouth type) was performed in schoolchildren (6-8 years old). Read More

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http://dx.doi.org/10.1097/MD.0000000000014875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426507PMC
March 2019
1 Read

Evidence of Astragalus injection combined platinum-based chemotherapy in advanced nonsmall cell lung cancer patients: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Mar;98(11):e14798

Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine.

Background: Platinum-based chemotherapy is one of the standard treatments for advanced nonsmall cell lung cancer (NSCLC). Despite on an effective treatment for advanced NSCLC patients, its high toxicity and limited clinical effects have raised big concerns. Astragalus injection (AGI) has been commonly employed as an adjutant chemotherapy drug for NSCLC in China. Read More

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http://dx.doi.org/10.1097/MD.0000000000014798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426520PMC
March 2019
1 Read
5.723 Impact Factor

Cognitive decline and mortality among community-dwelling Chinese older people.

BMC Med 2019 Mar 15;17(1):63. Epub 2019 Mar 15.

Dementia Care and Research Center, Clinical Research Division, Peking University Institute of Mental Health (Sixth Hospital), No. 51 Huayuanbei Road, Haidian District, Beijing, 100191, China.

Background: Whether cognitive decline is related to a higher risk of death independent of the initial cognitive function is inconclusive. Evidence of the association between cognitive decline and mortality among Chinese older people is limited. We aimed to examine whether cognitive decline, assessed by the rate of decrease in the Mini-Mental State Examination (MMSE) score, was associated with mortality independent of initial cognitive function (baseline MMSE score) among Chinese older people. Read More

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https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291
Publisher Site
http://dx.doi.org/10.1186/s12916-019-1295-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419492PMC
March 2019
4 Reads

Efficacy of erlotinib and celecoxib for patients with advanced non-small cell lung cancer: A retrospective study.

Medicine (Baltimore) 2019 Mar;98(10):e14785

Department of Hematology, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

This study evaluated the efficacy and toxicity of erlotinib and celecoxib (EC) for treating Chinese patients with advanced non-small cell lung cancer (ANSCLC) and epidermal growth factor receptor (EGFR) wild type.Totally, 75 subjects with ANSCLC and EGFR wild type were included. They all underwent EC treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000014785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417627PMC
March 2019
2 Reads

Effect of advanced care on psychological condition in patients with chronic renal failure undergoing hemodialysis: A protocol of a systematic review.

Authors:
Yun Guan Yu-Xia He

Medicine (Baltimore) 2019 Mar;98(10):e14738

Department of Nephrology, Yanan University Affiliated Hospital, Yan'an, China.

Background: The protocol of this systematic review will be proposed for assessing the effects of advanced care (AC) on psychological condition in patients with chronic renal failure (CRF) undergoing hemodialysis.

Methods: We will search the following electronic databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from inception to the January 30, 2019. Any randomized controlled trials (RCTs) for assessing the effects of AC on psychological condition in patients with CRF undergoing hemodialysis will be fully considered. Read More

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http://dx.doi.org/10.1097/MD.0000000000014738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417536PMC
March 2019
1 Read

Learning curve and short-term outcomes of modularized LADG for advanced gastric cancer: A retrospective study.

Medicine (Baltimore) 2019 Mar;98(10):e14670

Department of Gastrointestinal Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Laparoscopy-assisted distal gastrectomy (LADG) is a complicated procedure. To reduce the difficulty of the operation and standardize the surgical procedure, we explored a new operation mode, which we termed modularized LADG (MLADG). To further extend the new operation mode, we conducted this study to evaluate the short-term outcomes of MLADG for advanced gastric cancer, and determine the learning curve. Read More

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http://dx.doi.org/10.1097/MD.0000000000014670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417604PMC
March 2019
1 Read
5.723 Impact Factor

Increased expression of plakophilin 3 is associated with poor prognosis in ovarian cancer.

Medicine (Baltimore) 2019 Mar;98(10):e14608

Department of Pathology.

Considering the essential role of plakophilin 3 (PKP3) in the maintenance cell-cell adhesion, dysregulation of PKP3 is involved in human diseases. This study aimed to explore the clinical significance of PKP3 in ovarian cancer. Immunohistochemistry was performed to examine the PKP3 expression in 157 cancer specimens from primary ovarian cancer patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000014608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417525PMC
March 2019
4 Reads

Co-alteration of EGFR mutation and ALK rearrangement in non-small cell lung cancer: Case series.

Medicine (Baltimore) 2019 Mar;98(9):e14699

Department of Internal Medicine, Chonnam National University Medical School.

Rationale: Current guidelines for advanced non-small cell lung cancer (NSCLC) recommend the use of targeted agents for specific driver genes after confirming genetic alterations. Although epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement are usually mutually exclusive, EGFR and ALK co-alterations have been reported increasingly in cases of NSCLC. However, the optimal treatment for these cases has not been established. Read More

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http://dx.doi.org/10.1097/MD.0000000000014699DOI Listing

Prognostic and clinicopathological value of MUC1 expression in colorectal cancer: A meta-analysis.

Medicine (Baltimore) 2019 Mar;98(9):e14659

Department of Colorectal and Anal Surgery.

Background: Accumulating evidence supports the overexpression of mucin 1 (MUC1) in colorectal cancer (CRC), but the value of elevated MUC1 expression remains controversial. Here, we evaluated the prognostic and clinicopathological value of MUC1 expression in CRC.

Materials And Methods: The Web of Science, PubMed, Embase, Cochrane Library, and Wanfang databases, as well as the China Biology Medicine disc (CBMdisc) and China National Knowledge Infrastructure (CNKI) were searched for studies on MUC1 expression and prognosis of CRC through July 20, 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000014659DOI Listing
March 2019
2 Reads
5.723 Impact Factor

Characteristics of dry eye in patients with pre-existing Sjögren's syndrome according to the revised 2016 ACR-EULAR classification criteria.

Medicine (Baltimore) 2019 Mar;98(9):e14641

Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju.

To compare the characteristics of dry eye (DE) patients who did and did not satisfy the 2016 American College of Rheumatology (ACR)-European League Against Rheumatism (EULAR) classification criteria for primary Sjögren's syndrome (SS) among patients with pre-existing SS diagnosed according to the 2012 ACR criteriaThis cross-sectional study evaluated 91 patients with pre-existing SS and 55 with non-SS DE. Patients with SS were divided into 2 groups according to whether they met the revised 2016 ACR-EULAR classification criteria for primary SS. Group 1 (n = 71) was comprised of patients who satisfied the revised 2016 criteria and group 2 (n = 20) was comprised of patients who did not satisfy the newly revised criteria. Read More

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http://dx.doi.org/10.1097/MD.0000000000014641DOI Listing
March 2019
1 Read

Impact of inflammation-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation - the FIBRO-RISK study: Protocol for a non-randomized clinical trial.

Medicine (Baltimore) 2019 Mar;98(9):e14504

University of Medicine, Pharmacy, Sciences and Technology.

Introduction: Interventional ablation has been demonstrated to represent an effective therapy in patients with atrial fibrillation (AF), leading to restoration and maintenance of sinus rhythm in the majority of cases. However, recurrence of AF is encountered in 35% to 40% of cases, and the causes for this frequent complication have not been elucidated so far.

Material And Methods: Here we present the study protocol of the FIBRO-RISK trial, a prospective, single-center, cohort study which aims to investigate the impact of inflammatory-mediated myocardial fibrosis on the risk of recurrence after successful catheter ablation of atrial fibrillation. Read More

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http://dx.doi.org/10.1097/MD.0000000000014504DOI Listing
March 2019
3 Reads

Protocol for the development and validation of a driving simulator for evaluating the influence of drugs on driving performance.

Medicine (Baltimore) 2019 Feb;98(8):e14613

Department of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya, Aichi.

Introduction: Although automobile driving is often necessary in daily life, most package inserts for psychotropic drugs in Japan prohibit patients from driving under the influence of medication. This may be partially because no system to evaluate the influence of drugs on driving performance has been established. Standardized evaluation methods have been established in the Netherlands and the United States, but these cannot be implemented in Japan because of differences in road situations, traffic laws, and ethnicities. Read More

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http://dx.doi.org/10.1097/MD.0000000000014613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408048PMC
February 2019
1 Read

Apatinib treatment of advanced hepatocellular carcinoma with portal vein and inferior vena cava tumor thrombus: A case report.

Medicine (Baltimore) 2019 Feb;98(8):e14582

Department of Interventional Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.

Rationale: Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with vascular invasion. The survival of advanced HCC is very poor. In this case study, we describe the efficacy and safety of apatinib in patient with advanced HCC as the first-line therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408098PMC
February 2019
3 Reads

Prognostic factors in patients with advanced extrahepatic cholangiocarcinoma: A single center experience.

Medicine (Baltimore) 2019 Feb;98(8):e14556

Department of Medical Oncology, Acibadem University School of Medicine, Istanbul, Turkey.

Extrahepatic cholangiocarcinoma (ECC) is an aggressive malignancy causing a lot of fatalities and comorbidities. Endoscopic biliary stenting (EBS) is mostly needed for ECC. In this study, we aimed to investigate the prognostic factors for the overall survival (OS) and the factors predicting the patients eligible for chemotherapy after EBS in ECC. Read More

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http://dx.doi.org/10.1097/MD.0000000000014556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408093PMC
February 2019
5 Reads

Oral glutamine supplements reduce concurrent chemoradiotherapy-induced esophagitis in patients with advanced non-small cell lung cancer.

Medicine (Baltimore) 2019 Feb;98(8):e14463

Division of Chest Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Background: Complications related to concurrent chemoradiotherapy (CCRT) such as acute radiation-induced esophagitis (ARIE) may cause significant morbidity and unplanned treatment delays in patients with advanced non-small cell lung cancer (NSCLC). We designed a prospective randomized study to assess the impact of glutamine (GLN) supplementation in preventing CCRT-induced toxicities of advanced NSCLC patients.

Methods: From September 2014 to September 2015, 60 patients diagnosed with NSCLC were included to the study. Read More

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http://dx.doi.org/10.1097/MD.0000000000014463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408144PMC
February 2019
3 Reads

The association between heatwaves and risk of hospitalization in Brazil: A nationwide time series study between 2000 and 2015.

PLoS Med 2019 Feb 22;16(2):e1002753. Epub 2019 Feb 22.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Background: To our knowledge, no study has assessed the association between heatwaves and risk of hospitalization and how it may change over time in Brazil. We quantified the heatwave-hospitalization association in Brazil during 2000-2015.

Methods And Findings: Daily data on hospitalization and temperature were collected from 1,814 cities (>78% of the national population) in the hottest five consecutive months during 2000-2015. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386221PMC
February 2019
1 Read

Characteristics of late-onset spondyloarthritis in Japan: A retrospective cohort study.

Medicine (Baltimore) 2019 Feb;98(7):e14431

Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences.

Spondyloarthritis may be increasingly present in older patients as life expectancy increases. We investigated clinical differences between early-onset and late-onset spondyloarthritis in Japan.We retrospectively reviewed 114 patients consecutively diagnosed with spondyloarthritis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407927PMC
February 2019
2 Reads

Association of SENPs single-nucleotide polymorphism and breast cancer in Chinese population.

Medicine (Baltimore) 2019 Feb;98(6):e14168

Department of Pharmacy.

SUMO-specific Cysteine Proteases (SENPs) have involvement in the initiation and progression of human cancers. In the present study, we evaluated the association of SENPs polymorphism with susceptibility as well as clinicopathologic features and patients' response of breast cancer (BC) in a Chinese population.We genotyped SENP1 (rs61918808), SENP2 (rs6762208), SENP7 (rs61697963) by sequencing in a case-control study including 210 BC patients and 225 healthy volunteers. Read More

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http://dx.doi.org/10.1097/MD.0000000000014168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380865PMC
February 2019
5.723 Impact Factor

Liver fibrosis is associated with risk for colorectal adenoma in patients with nonalcoholic fatty liver disease.

Medicine (Baltimore) 2019 Feb;98(6):e14139

Medical Research Collaboration Center in KNUH and School of Medicine, Kyungpook National University, Daegu, South Korea.

Nonalcoholic fatty liver disease (NAFLD) is associated with risks for developing colorectal adenoma. This study aimed to evaluate the association between advanced fibrosis in NAFLD and the risk for colorectal adenoma.We retrospectively analyzed the data of 6332 adults who underwent abdominal ultrasound and 1st-time colonoscopy on the same day in a health screening program at a single center. Read More

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http://dx.doi.org/10.1097/MD.0000000000014139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380844PMC
February 2019
1 Read

Efficacy and toxicity of apatinib combined with or without chemotherapy for patients with advanced or metastatic chemotherapy-refractory gastric adenocarcinoma: A prospective clinical study.

Medicine (Baltimore) 2019 Feb;98(6):e13908

Department of Chemotherapy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research &The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Apatinib (Jiangsu HengRui Medicine Co. Ltd), a vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitor, has been proven to be safe and to significantly prolong survival in advanced chemotherapy-refractory gastric cancer. This study aimed to assess and compare the efficacy and safety of apatinib combined with chemotherapy with that of chemotherapy alone as second- or higher-line treatment in patients with advanced and metastatic gastric or those with metastatic gastroesophageal junction adenocarcinoma (mGC). Read More

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http://dx.doi.org/10.1097/MD.0000000000013908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380695PMC
February 2019
2 Reads

Enhanced functional connectivity of the default mode network (DMN) in patients with spleen deficiency syndrome: A resting-state fMRI study.

Medicine (Baltimore) 2019 Feb;98(5):e14372

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University.

Numerous studies had investigated the biological basis of spleen deficiency syndrome on gastrointestinal dysfunctions. However, little was known about neuropsychological mechanism of spleen deficiency syndrome. The default model network (DMN) plays an important role in cognitive processing. Read More

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http://dx.doi.org/10.1097/MD.0000000000014372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380821PMC
February 2019

The impact of advanced maternal age on the outcomes of very low birth weight preterm infants.

Medicine (Baltimore) 2019 Feb;98(5):e14336

Department of Neonatology, MacKay Children's Hospital, Taipei.

The association between advanced maternal age and neonatal outcomes remains controversial. This study attempted to determine the short-term and long-term outcomes of very low birth weight (VLBW, <1500 g) preterm infants, born to mothers of advanced age (≥35 years).In this retrospective cohort study, VLBW infants were divided into the advanced maternal age group and comparison group. Read More

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http://dx.doi.org/10.1097/MD.0000000000014336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380823PMC
February 2019

Efficacy of sorafenib adjuvant therapy in northwestern Chinese patients with non-metastatic renal-cell carcinoma after nephrectomy: A multicenter retrospective study.

Medicine (Baltimore) 2019 Feb;98(5):e14237

Department of Urology, Xijing Hospital, Fourth Military Medical University.

Recent studies have confirmed the efficacy of sorafenib for patients with advanced renal cell carcinoma; however, its efficacy and safety as an adjuvant therapy in patients with non-metastatic and loco-regional renal cell carcinoma after surgery remains controversial. Thus, the aim of the present retrospective study was to evaluate the efficacy of adjuvant sorafenib therapy in such patients from 8 centers in northwestern China that were treated from August 2009 to December 2016.After surgery, the patients (n = 48) received oral sorafenib for 3 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000014237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380792PMC
February 2019
2 Reads

Herbal medicine (Hyeolbuchukeo-tang or Xuefu Zhuyu decoction) for treating primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2019 Feb;98(5):e14170

Department of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

Background: Primary dysmenorrhea is a condition characterized by painful menstrual cramps that usually occurs in the absence of any identifiable pathological condition among menstruating women, with the prevalence estimates varying between 45% and 95%. Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as a standard treatment for primary dysmenorrhea; however, the failure rate of NSAIDs is often 20% to 25% and these drugs commonly cause adverse effects. In this review, we investigated the current evidence related to the effectiveness of Xuefu Zhuyu decoction (XZD) or Hyeolbuchukeo-tang, a traditional herbal formula, as a treatment for primary dysmenorrhea. Read More

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http://dx.doi.org/10.1097/MD.0000000000014170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380829PMC
February 2019
10 Reads

Significant response of low-dose apatinib monotherapy in brain metastases of triple-negative breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14182

Department of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, P. R. China.

Rationale: The potential efficacy of apatinib in patients with advanced triple-negative breast cancer (TNBC) has been observed in a previous phase II clinical study. However, there is no study to evaluate its efficacy and safety in TNBC patients with brain metastasis (BM). Here we report one case that apatinib exhibited excellent antitumor effects in a breast cancer patient with brain metastasis, with no serious treatment-associated with adverse event. Read More

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http://dx.doi.org/10.1097/MD.0000000000014182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358397PMC
January 2019
2 Reads

Impact of prehospital mechanical ventilation: A retrospective matched cohort study of 911 calls in the United States.

Medicine (Baltimore) 2019 Jan;98(4):e13990

Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.

Prehospital use of ventilators by emergency medical services (EMS) during 911 calls is increasing. This study described the impact of prehospital mechanical ventilation on prehospital time intervals and on mortality.This retrospective matched-cohort study used 4 consecutive public releases of the US National Emergency Medical Services Information System dataset (2011-2014). Read More

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http://dx.doi.org/10.1097/MD.0000000000013990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358412PMC
January 2019
1 Read

Pancreatitis cytosorbents (CytoSorb) inflammatory cytokine removal: A Prospective Study (PACIFIC).

Medicine (Baltimore) 2019 Jan;98(4):e13044

Medizinische Klinik I, Kliniken Nordoberpfalz, Klinikum, Weiden, Germany.

Background: Acute pancreatitis (AP) usually has a mild course with a mortality rate below 1%. However, around 10% of patients develop severe AP (SAP) involving extra-pancreatic tissues and other organ systems. The mortality of SAP is around 42%. Read More

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http://dx.doi.org/10.1097/MD.0000000000013044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358351PMC
January 2019
9 Reads

Acupotomy for the treatment of lumbar spinal stenosis: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(3):e14160

Chung-Yeon Central Institute, Gwangju, Republic of Korea.

Introduction: This systematic review protocol describes the methods that will be used to evaluate the efficacy and safety of acupotomy for the treatment of lumbar spinal stenosis.

Methods And Analysis: The following electronic databases will be searched until December 2018 without language or publication status restrictions: five English databases, that is Medline, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Allied and Complementary Medicine Database (AMED), and Cumulative Index to Nursing and Allied Health Literature (CINAHL); three Korean databases, that is Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Service System (RISS), and Korea Citation Index (KCI); and three Chinese databases, that is China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP. Any clinical, randomized controlled trials using acupotomy for lumbar spinal stenosis treatment will be included. Read More

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http://dx.doi.org/10.1097/MD.0000000000014160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370031PMC
January 2019
1 Read

Prognostic value of PD-L1 expression in patients with pancreatic cancer: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Jan;98(3):e14006

Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing 210028, Jiangsu Province, China.

Background: Programmed cell death ligand 1 (PD-L1) expression was reported to be associated with poor prognosis in various solid tumors. However, the prognosis value of PD-L1 in pancreatic cancer remained inconclusive. We performed a meta-analysis to assess the clinical value of PD-L1 as a novel prognostic biomarker of pancreatic cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370132PMC
January 2019
17 Reads

No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study.

PLoS Med 2019 Jan 15;16(1):e1002725. Epub 2019 Jan 15.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Background: Studies have shown strong positive associations between serum urate (SU) levels and chronic kidney disease (CKD) risk; however, whether the relation is causal remains uncertain. We evaluate whether genetic data are consistent with a causal impact of SU level on the risk of CKD and estimated glomerular filtration rate (eGFR).

Methods And Findings: We used Mendelian randomization (MR) methods to evaluate the presence of a causal effect. Read More

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http://dx.plos.org/10.1371/journal.pmed.1002725
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http://dx.doi.org/10.1371/journal.pmed.1002725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333326PMC
January 2019
18 Reads

Musculoskeletal ultrasound: a useful tool for diagnosis of hip developmental dysplasia: One single-center experience.

Medicine (Baltimore) 2019 Jan;98(2):e14081

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mureş, Romania.

Developmental dysplasia of the hip (DDH) is one of the most common congenital abnormalities of the musculoskeletal apparatus in newborns. The aim of this study was to analyze the contribution of ultrasonography in the detection of DDH in newborns and infants, identifying the regional incidence of this pathology in the central area of Romania, emphasizing the risk factors that underlie DDH etiopathogenicity.This article represents a retrospective study of 847 newborns and infants examined in the Imagistic Department of a medical center from the central area of Romania, between January 1 and December 31, 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000014081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336624PMC
January 2019
7 Reads

Acupuncture for pain caused by prostate cancer: Protocol for a systematic review.

Medicine (Baltimore) 2019 Jan;98(2):e13954

Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing.

Background: Prostate cancer is a male malignant tumor disease with high prevalence in recent years. Patients with advanced prostate cancer are more likely to have bone metastasis and strong bone pain, and even lead to pathological fracture, which has a serious impact on the quality of life of patients. Acupuncture has good clinical efficacy in treating pain caused by prostate cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000013954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336609PMC
January 2019
14 Reads

Human papilloma virus identification in ocular surface squamous neoplasia by p16 immunohistochemistry and DNA chip test: A strobe-compliant article.

Medicine (Baltimore) 2019 Jan;98(2):e13944

Department of Ophthalmology and Research Institute of Medical Sciences.

The aim of this study was to identify the association between human papilloma virus (HPV) infection and ocular surface squamous neoplasia (OSSN) using p16 immunohistochemistry (IHC) and deoxyribonucleic acid (DNA) chip test.Thirty-eight patients who underwent surgical excision of OSSN were retrospectively studied using tissue samples. The IHC was performed to assess the expression of p16 and DNA chip test was used to detect 24 HPV serotypes. Read More

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http://dx.doi.org/10.1097/MD.0000000000013944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336645PMC
January 2019
1 Read

Health system costs for individual and comorbid noncommunicable diseases: An analysis of publicly funded health events from New Zealand.

PLoS Med 2019 Jan 8;16(1):e1002716. Epub 2019 Jan 8.

Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.

Background: There is little systematic assessment of how total health expenditure is distributed across diseases and comorbidities. The objective of this study was to use statistical methods to disaggregate all publicly funded health expenditure by disease and comorbidities in order to answer three research questions: (1) What is health expenditure by disease phase for noncommunicable diseases (NCDs) in New Zealand? (2) Is the cost of having two NCDs more or less than that expected given the independent costs of each NCD? (3) How is total health spending disaggregated by NCDs across age and by sex?

Methods And Findings: We used linked data for all adult New Zealanders for publicly funded events, including hospitalisation, outpatient, pharmaceutical, laboratory testing, and primary care from 1 July 2007 to 30 June 2014. These data include 18. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324792PMC
January 2019
3 Reads

Trigger finger secondary to a neglected flexor tendon rupture.

Medicine (Baltimore) 2019 Jan;98(1):e13980

Department of Orthopedic Surgery, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Chonbuk, Republic of Korea.

Secondary trigger finger caused by trauma to the hand, especially associated with partial flexor tendon rupture, is not a common condition. Thus, the clinical manifestations of these patients are not well-known. The aim of this study is to present secondary trigger finger caused by a neglected partial flexor tendon rupture including discussion of the mechanism and treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000013980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344173PMC
January 2019
3 Reads

Meta-analysis of overall incidence and risk of ALK inhibitors-induced liver toxicities in advanced non-small-cell lung cancer.

Medicine (Baltimore) 2019 Jan;98(1):e13726

Aim: Activation of the anaplastic lymphoma kinase (ALK) gene has been found in several human cancers, including non-small-cell lung cancer (NSCLC). Currently, novel drugs targeting ALK gene have been extensively investigated in NSCLC. However, concerns about ALK inhibitors-induced liver toxicities have been increasing. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901040-0000
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http://dx.doi.org/10.1097/MD.0000000000013726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344205PMC
January 2019
16 Reads

Self-perceived limitations and difficulties by Primary Health Care Physicians to assist emergencies.

Medicine (Baltimore) 2018 Dec;97(52):e13819

The study was aimed to identify the training received in Emergency Medicine by physicians and the limitations and difficulties self-perceived by those physicians to assist in emergencies, as well as to analyze the differences according to the work context.Observational cross-sectional study made by a survey using a self-administered questionnaire to a representative simple random sample (with replacement) of 294 doctors (n) working at the Primary Health Care centers out of the total of 851 doctors (N) that form the staff of physicians of Primary Health Care system of Asturias (Spain).In rural areas, the most frequently mentioned reasons were the lack of practical skills (32. Read More

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http://dx.doi.org/10.1097/MD.0000000000013819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314741PMC
December 2018
1 Read

Staged reconstructive treatment for extensive irregular cicatricial alopecia after burn.

Medicine (Baltimore) 2018 Dec;97(52):e13522

Department of Plastic Surgery, Affiliated Hangzhou First People's Hospital.

For extensive irregular cicatricial alopecia after burn, effective and pleasing restoration of hair-bearing scalp remains challenging. In this article, the authors presented staged reconstructive treatment for extensive irregular cicatricial alopecia with the goal to achieve better and reliable results. A retrospective review of staged reconstructive treatment performed in 16 patients with extensive irregular cicatricial alopecia after burn was conducted. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0000
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http://dx.doi.org/10.1097/MD.0000000000013522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314779PMC
December 2018
7 Reads

Nonsmall cell lung cancer with rare exon 7 p.A289V mutation in the EGFR gene responds to Icotinib treatment: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13809

Department of Clinical Oncology, 901 Hospital of Joint Logistics Support Force (The 105 Hospital of People Liberation Army), Hefei, Anhui, China.

Rationale: Mutation p.A289V involving extracellular region of epidermal growth factor receptor (EGFR) exon 7 has not yet been reported in nonsmall cell lung cancer (NSCLC). Studies have shown p. Read More

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http://dx.doi.org/10.1097/MD.0000000000013809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319919PMC
December 2018
5 Reads

Effect of nerve electrical stimulation for treating chemotherapy-induced nausea and vomiting in patients with advanced gastric cancer: A randomized controlled trial.

Medicine (Baltimore) 2018 Dec;97(51):e13620

Department of Gastroenterology, Yulin No.2 Hospital, Yulin, Shaanxi, China.

Background: This randomized controlled trial evaluated the effectiveness of nerve electrical stimulation (NES) for the treatment of chemotherapy-induced nausea and vomiting (CINV) in patients with advanced gastric cancer (AGC).

Methods: One hundred twenty-four eligible patients with AGC were included in this randomized controlled trial. They were equally divided the NES group and the sham group. Read More

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http://dx.doi.org/10.1097/MD.0000000000013620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319986PMC
December 2018
4 Reads