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    Should fraction flow reserve be considered an important decision-making tool to stratify patients with stable coronary artery disease for percutaneous coronary intervention?: A meta-analysis.
    Medicine (Baltimore) 2017 Nov;96(46):e8748
    aInstitute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi Medical University bGuangxi Medical University cInstitute of Cardiovascular Diseases and Guangxi Key Laboratory Base of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P. R. China.
    Background: Nowadays, fraction flow reserve (FFR) is being discussed in every percutaneous coronary intervention (PCI) capable hospitals. Owing to recent development in the medical field, FFR-guided PCI should be able to find a place in Interventional Cardiology. At present, the importance of FFR to stratify patients who require PCI has seldom systematically been investigated. Read More

    Indications and outcomes of pediatric keratoplasty in a tertiary eye care center: A retrospective review.
    Medicine (Baltimore) 2017 Nov;96(45):e8587
    aResearch Department, Association to Prevent Blindness in Mexico IAP, "Dr. Luis Sanchez Bulnes Hospital" bCell Biology Department, Center for Advanced Research and Studies of the IPN, CINVESTAV-IPN cCornea Department, Association to Prevent Blindness in Mexico IAP, "Dr. Luis Sanchez Bulnes Hospital", Mexico City, Mexico.
    To evaluate indications and outcomes of pediatric keratoplasty in a tertiary eye center, and identify factors that affect visual outcomes.We performed a retrospective review of penetrating keratoplasty in children aged 0 to 18 years between 1995 and 2011 in the Asociación para Evitar la Ceguera en México IAP, Hospital "Dr. Luis Sánchez Bulnes". Read More

    A case report of mixed acinar-endocrine carcinoma of the pancreas treated with S-1 chemotherapy: Does it work or induce endocrine differentiation?
    Medicine (Baltimore) 2017 Nov;96(45):e8534
    aDepartment of Gastroenterology and Hepatology, Kobe City Medical Center West Hospital bDepartment of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
    Rationale: Acinar cell carcinomas (ACCs) and mixed acinar-endocrine carcinomas (MAECs) of the pancreas are rare, accounting for only 1% of pancreatic tumors. Although both typically present at an advanced stage, chemotherapeutic regimes have not yet been standardized.

    Patient Concerns: A 65-year-old man presented with a large mass in the pancreatic tail with multiple liver metastases. Read More

    Outcomes of percutaneous coronary intervention in patients with coronary chronic total occlusions with versus without type 2 diabetes mellitus: A systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Nov;96(45):e8499
    aInstitute of Cardiovascular Diseases, Yichang Central People's Hospital, Yichang, Hubei Province bInstitute of Cardiovascular Diseases, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P. R. China.
    Background: Nowadays, due to advanced techniques and well-trained interventionists in catheter labs, new scientific research has shown percutaneous coronary intervention (PCI) to be a safe treatment procedure in patients with chronic total occlusion (CTO). However, no study has systematically compared PCI outcomes in CTO patients with versus without type 2 diabetes mellitus (T2DM). Therefore, through this meta-analysis we aimed to systematically solve this issue. Read More

    Validity of a minimally invasive autopsy for cause of death determination in maternal deaths in Mozambique: An observational study.
    PLoS Med 2017 Nov 8;14(11):e1002431. Epub 2017 Nov 8.
    ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain.
    Background: Despite global health efforts to reduce maternal mortality, rates continue to be unacceptably high in large parts of the world. Feasible, acceptable, and accurate postmortem sampling methods could provide the necessary evidence to improve the understanding of the real causes of maternal mortality, guiding the design of interventions to reduce this burden.

    Methods And Findings: The validity of a minimally invasive autopsy (MIA) method in determining the cause of death was assessed in an observational study in 57 maternal deaths by comparing the results of the MIA with those of the gold standard (complete diagnostic autopsy [CDA], which includes any available clinical information). Read More

    Clinicopathological factors associated with HER2-positive gastric cancer: A meta-analysis.
    Medicine (Baltimore) 2017 Nov;96(44):e8437
    Department of General Surgery, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei, China.
    Background: The treatment of patients with advanced gastric cancer remains a most challenging task in the clinical practice. Recently, targeted therapies have significantly impacted the treatment strategy for many common malignancies. The use of trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2; also known as ERBB2), plus chemotherapy proved to improve median overall survival in patients with advanced gastric cancer, compared with chemotherapy alone in Trastuzumab for Gastric Cancer (ToGA) trial. Read More

    Experience of weekly cisplatin concurrent with intensity-modulated radiotherapy for locally advanced nasopharyngeal carcinoma patients with resistance to neoadjuvant chemotherapy.
    Medicine (Baltimore) 2017 Nov;96(44):e8434
    aDepartment of Radiation Oncology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University bProvincial Clinical College, Fujian Medical University cDepartment of Radiation Oncology, Cancer Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
    Nasopharyngeal carcinoma (NPC) is highly sensitive to radiotherapy. Locally advanced NPC has a relatively poor prognosis if treated with radiotherapy alone. Several studies have demonstrated that chemoradiotherapy confers survival benefit in locally advanced NPC. Read More

    Immune-related adverse events associated with PD-1 and PD-L1 inhibitors for nonsmall cell lung cancer: Protocol for a systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Nov;96(44):e8407
    aDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine bInstitute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China cOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran dDepartment of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Shandong academy of Medical Science, Jinan, Shandong, China.
    Introduction: Nonsmall cell lung cancer accounts for approximately 80% of all lung cancers, and approximately 75% of cases are diagnosed in the middle and late stages of disease. Unfortunately, limited treatment does not improve the prognosis of advanced disease. Monoclonal antibodies targeting programmed cell death protein-1 (PD-1) and programmed death-ligand 1 (PD-L1) represent a new treatment paradigm for nonsmall cell lung cancer. Read More

    Comparison of breast-conserving surgery with mastectomy in locally advanced breast cancer after good response to neoadjuvant chemotherapy: A PRISMA-compliant systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Oct;96(43):e8367
    aDepartment of General Surgery bDepartment of Traditional Chinese Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Discipline Construction Research Center of China Hospital Development Institute, Shanghai Jiao Tong University cDepartment of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Discipline Construction Research Center of China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, 200011, China.
    Background: The application of breast-conserving surgery (BCS) on patients with locally advanced breast cancer (LABC) with good response to neoadjuvant chemotherapy (NACT) still remains controversial. The objective in this study is to analyze the safety of BCS in the management of LABC in patients with good response to NACT.

    Methods: We searched the electronic databases of Medline (Pubmed) and Cochrane Library for reports on local recurrence (LR), regional recurrence (RR), distant recurrence (DR), 5-year disease-free survival (DFS) or 5-year overall survival (OS) in patients with LABC receiving BCS or mastectomy (MT) and with good response to NACT. Read More

    Risk of rash associated with vandetanib treatment in non-small-cell lung cancer patients: A meta-analysis of 9 randomized controlled trials.
    Medicine (Baltimore) 2017 Oct;96(43):e8345
    Department of Dermatovenereology, Tianjin Medical University General Hospital, Tianjin, China.
    Background: Vandetanib is a promising anticancer target agent for treating advanced carcinomas, such as non-small-cell lung cancer (NSCLC) and breast cancer. Rash is a frequently reported adverse event of vandetanib. We conducted this meta-analysis to determine the incidence rate and overall risks of all-grade and high-grade rash with vandetanib in NSCLC patients. Read More

    Outcomes of patients with abdominoperineal resection (APR) and low anterior resection (LAR) who had very low rectal cancer.
    Medicine (Baltimore) 2017 Oct;96(43):e8249
    aDepartment of Colon and Rectal Surgery bDepartment of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
    We compared the oncological outcomes of sphincter-saving resection (SSR) and abdominoperineal resection (APR) in 409 consecutive patients with very low rectal cancer (i.e., tumors within 3 cm from the anal verge); 335 (81. Read More

    Effectiveness of cervical screening after age 60 years according to screening history: Nationwide cohort study in Sweden.
    PLoS Med 2017 Oct 24;14(10):e1002414. Epub 2017 Oct 24.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Background: The relatively high incidence of cervical cancer in women at older ages is a continuing concern in countries with long-established cervical screening. Controversy remains on when and how to cease screening. Existing population-based studies on the effectiveness of cervical screening at older ages have not considered women's screening history. Read More

    Comparison of oncological outcomes of right-sided colon cancer versus left-sided colon cancer after curative resection: Which side is better outcome?
    Medicine (Baltimore) 2017 Oct;96(42):e8241
    Section of Colon and Rectal Surgery, Department of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
    Propose: There are embryological origins, anatomical, histological, genetic, and immunological differences between right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Many studies have sought to determine the survival and prognosis according to tumor location. This study aimed to analyze outcomes between RCC and LCC. Read More

    Retrospective analysis for the false positive diagnosis of PET-CT scan in lung cancer patients.
    Medicine (Baltimore) 2017 Oct;96(42):e7415
    aDepartment of Respiratory Disease bDepartment of Pathology, Daping Hospital, Third Military Medical University, Chongqing, China.
    Early diagnosis is pivotal for prognosis of lung cancer patients. Positron emission tomography/computed tomography (PET-CT) is a useful method for human cancer diagnosis. In this study, we aimed to explore the false positive diagnosis of PET-CT in lung cancerIn total, 754 patients diagnosed with lung cancer via PET-CT were retrospectively collected in this study. Read More

    Tuberculosis detection and the challenges of integrated care in rural China: A cross-sectional standardized patient study.
    PLoS Med 2017 Oct 17;14(10):e1002405. Epub 2017 Oct 17.
    Development Research Group, The World Bank, Washington, D.C., United States of America.
    Background: Despite recent reductions in prevalence, China still faces a substantial tuberculosis (TB) burden, with future progress dependent on the ability of rural providers to appropriately detect and refer TB patients for further care. This study (a) provides a baseline assessment of the ability of rural providers to correctly manage presumptive TB cases; (b) measures the gap between provider knowledge and practice and; (c) evaluates how ongoing reforms of China's health system-characterized by a movement toward "integrated care" and promotion of initial contact with grassroots providers-will affect the care of TB patients.

    Methods/findings: Unannounced standardized patients (SPs) presenting with classic pulmonary TB symptoms were deployed in 3 provinces of China in July 2015. Read More

    The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study.
    PLoS Med 2017 Oct 10;14(10):e1002400. Epub 2017 Oct 10.
    Renal Unit, Royal Derby Hospital, Derby, United Kingdom.
    Background: To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK and international guidelines recommend that cystatin-C-based estimates of GFR be used to confirm or exclude the diagnosis in people with GFR 45-59 ml/min/1.73 m2 and no albuminuria (CKD G3aA1). Whilst there is good evidence for cystatin C being a marker of GFR and risk in people with CKD, its use to define CKD in this manner has not been evaluated in primary care, the setting in which most people with GFR in this range are managed. Read More

    Outcomes of robotic versus laparoscopic surgery for mid and low rectal cancer after neoadjuvant chemoradiation therapy and the effect of learning curve.
    Medicine (Baltimore) 2017 Oct;96(40):e8171
    aDepartment of Surgery, College of Medicine bDivision of Gastrointestinal Surgery, Department of Surgery cCancer Research Center dDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Hospital eDivision of Colorectal Surgery, Department of Surgery, Wan Fang Hospital fTranslational Laboratory, Department of Medical Research, Taipei Medical University Hospital gGraduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan.
    Randomized controlled trials have demonstrated that laparoscopic surgery for rectal cancer is safe and can accelerate recovery without compromising oncological outcomes. However, such a surgery is technically demanding, limiting its application in nonspecialized centers. The operational features of a robotic system may facilitate overcoming this limitation. Read More

    Flattening effect of corneal cross-linking depends on the preoperative severity of keratoconus.
    Medicine (Baltimore) 2017 Oct;96(40):e8160
    aDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba bDepartment of Ophthalmology, Jikei University School of Medicine, Tokyo cDepartment of Ophthalmology, Saitama Medical University Hospital, Saitama dDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
    A retrospective observational study was conducted to validate the effect of corneal cross-linking (CXL) on eyes with progressing keratoconus, depending on severity.In total, 45 eyes of 33 patients (age: 23.9 ± 6. Read More

    Clinicopathological, radiographic, and oncogenic features of primary pulmonary enteric adenocarcinoma in comparison with invasive adenocarcinoma in resection specimens.
    Medicine (Baltimore) 2017 Sep;96(39):e8153
    Department of Nuclear Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
    Primary pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of primary lung adenocarcinoma. However, it is not known whether there are any distinctive clinical or molecular features.PEACs were retrospectively identified in 28 patients from July 2014 to June 2016. Read More

    Clinical characteristics of angioimmunoblastic T-cell lymphoma in China and C-reactive protein as an independent prognostic factor.
    Medicine (Baltimore) 2017 Sep;96(39):e8091
    aDepartment of Hematology, the First Affiliated Hospital of Zhejiang University bInstitute of Hematology, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
    Angioimmunoblastic T-cell lymphoma (AITL) is a major subtype of peripheral T-cell lymphoma (PTCL). Due to its low incidence, the characteristics of AITL are still not well understood. The prognostic evaluation of this disease has not been established. Read More

    SYNTAX score based on coronary computed tomography angiography may have a prognostic value in patients with complex coronary artery disease: An observational study from a retrospective cohort.
    Medicine (Baltimore) 2017 Sep;96(37):e7999
    aDepartment of Radiology, Research Institute of Radiological Science, Severance Hospital bBiostatistics Collaboration Unit, Medical Research Center, Yonsei University College of Medicine, Seoul, Korea.
    The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score is an invasive coronary angiography (ICA)-based score for quantifying the complexity of coronary artery disease (CAD). Although the SYNTAX score was originally developed based on ICA, recent publications have reported that coronary computed tomography angiography (CCTA) is a feasible modality for the estimation of the SYNTAX score.The aim of our study was to investigate the prognostic value of the SYNTAX score, based on CCTA for the prediction of major adverse cardiac and cerebrovascular events (MACCEs) in patients with complex CAD. Read More

    The prognostic value and potential drug target of phosphatase and tensin homolog in breast cancer patients: A meta-analysis.
    Medicine (Baltimore) 2017 Sep;96(36):e8000
    Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
    Background: The prognostic significance of phosphatase and tensin homolog (PTEN) in patients with breast cancer (BC) remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic value in patients with breast cancer.

    Methods: PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure (CNKI) were systematically searched up to December 2016. Read More

    Clinical features of idiopathic restrictive cardiomyopathy: A retrospective multicenter cohort study over 2 decades.
    Medicine (Baltimore) 2017 Sep;96(36):e7886
    aDepartment of Cardiology, Asan Medical Center, University of Ulsan College of Medicine bDepartment of Internal Medicine, Seoul National University Hospital cDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul dDepartment of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju eDepartment of Internal Medicine, Wonju College of Medicine,Yonsei University, Wonju fDepartment of Internal Medicine, Kangbuk Samsung Hospital, Seoul gDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University school of Medicine, Bundang hDepartment of Cardiology, Sejong General Hospital iDepartment of Cardiovascular Medicine, Gachon University Gil Medical Center, Incheon jDepartment of Internal Medicine, Chungbuk National University School of Medicine, Cheongju, Korea.
    Idiopathic restrictive cardiomyopathy (RCMP) has not been fully understood because this disease is difficult to diagnose. The present study aimed to assess the clinical profile and outcome of idiopathic RCMP from a multicenter cohort.This investigation is a retrospective study of consecutive patients with idiopathic RCMP at 10 centers in Korea between 1990 and 2010. Read More

    Is serum high-mobility group box 1 (HMGB-1) level correlated with liver fibrosis in chronic hepatitis B?
    Medicine (Baltimore) 2017 Sep;96(36):e7547
    aDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara bDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Selçuk University, Konya cDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Adiyaman University, Adiyaman dDepartment of Public Health, Faculty of Medicine, Necmettin Erbakan University, Konya eDepartment of Pathology, Adiyaman Education and Research Hospital, Adiyaman fDepartment of Biochemistry, Adiyaman Education and Research Hospital, Adiyaman gDepartment of Biochemistry, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
    Background: High-mobility group box 1 (HMGB1), identified as an alarmin molecule, was shown to have a role in virus-triggered liver injury. We aimed to evaluate the association between serum levels of HMGB1 and liver fibrosis.

    Method: This cross-sectional case-control study included 189 chronic hepatitis B (CHB) patients and 51 healthy controls. Read More

    Comparison of definitive chemoradiotherapy and radiotherapy alone in patients older than 75 years with locally advanced esophageal carcinoma: A retrospective cohort study.
    Medicine (Baltimore) 2017 Sep;96(35):e7920
    aThe Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou province bSchool of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong province cDepartment of Rehabilitation, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou province, China.
    The aim of this study was to evaluate the efficacy and acute toxicity of definitive chemoradiotherapy (CRT) and radiotherapy (RT) alone as initial treatment in patients aged 75 years and older with locally advanced esophageal squamous cell carcinoma (ESCC) who are not eligible for surgery.Between February 2009 and February 2015, 122 patients older than 75 years with locally advanced ESCC were retrospectively reviewed, in whom 52 patients allocated to the CRT group were treated with at least 2 cycles of platinum and 5-fluorouracil, 70 patients allocated to the RT group were treated with RT alone, all patients were received a total radiation dose of 54-66 Gy, with 1.8 or 2-Gy/fraction. Read More

    Comparative analysis of diagnostic colonoscopy in symptomatic young adults from South Korea and the United States.
    Medicine (Baltimore) 2017 Sep;96(35):e7504
    aDepartment of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine bDepartment of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea cDigestive Disease Institute, Virginia Mason Medical Center, Seattle, WA.
    To date, not much is known about ethnic differences in the prevalence of colorectal neoplasia in symptomatic young patients with lower gastrointestinal symptoms. This study sought to compare diagnostic colonoscopic findings in symptomatic young patients from South Korea and the United States. Results from the first diagnostic colonoscopies in symptomatic 18- to 49-year-old patients were compared between the United States and Korean cohorts. Read More

    Trend analysis of end-of-life care between hospice and nonhospice groups of cancer patients in Taiwan for 2002-11.
    Medicine (Baltimore) 2017 Aug;96(34):e7825
    aDepartment of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi bDivision of Hematology and Oncology, Tainan Municipal Hospital, Tainan cDepartment of Family Medicine, Tainan Municipal Hospital, Tainan, Taiwan.
    The aim of the study is to examine the effect of hospice care on quality of end-of-life (EOL) care for patients with advanced cancer in Taiwan between 2002 and 2011.It is a population-based longitudinal study following National Health Insurance medical care claims of hospice and nonhospice patients with advanced cancer in their last month of life.Utilization of hospice service doubled from 10. Read More

    Effective apatinib treatment of pleomorphic liposarcoma: A case report.
    Medicine (Baltimore) 2017 Aug;96(33):e7771
    Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
    Rationale: Pleomorphic liposarcoma (PLS) is a rare and aggressive malignant tumor, and both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease.

    Patient Concerns: We presented an 81-year-old Chinese woman with advanced PLS who received apatinib after failure chemotherapy.

    Diagnoses: The patient was diagnosed as having PLS by biopsy. Read More

    Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma.
    Medicine (Baltimore) 2017 Aug;96(32):e7764
    aTianjin Key Laboratory of Artificial Cell, Tianjin Institute of Hepatobiliary Disease, Artificial Cell Engineering Technology Research Center of Public Health Ministry bDepartment of General Surgery, Third Central Hospital of Tianjin, Tianjin, China.
    The aim of the study was to explore the clinical significance of let-7 expression in hepatocellular carcinoma (HCC).A PCR array was conducted to screen for let-7 expression in early-stage HCC. Next, the deregulation of let-7 was confirmed by quantitative real-time RT-PCR (qRT-PCR) in another set of liver tissues, including normal control (NC), chronic hepatitis (CH), liver cirrhosis (LC), HCC, and adjacent nontumor (NT) tissues. Read More

    Effects of calcium on the incidence of recurrent colorectal adenomas: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials.
    Medicine (Baltimore) 2017 Aug;96(32):e7661
    aSchool of Pharmacy/School of Postgraduate Studies, International Medical University, Kuala Lumpur bDepartment of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia cMalaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, Malaysia dClinical School, Department of Surgery, International Medical University, Seremban, Negeri Sembilan, Malaysia eCenter of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, Thailand fSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia gCenter of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok hUnit of Excellence on Herbal Medicine, School of Pharmaceutical Sciences, University of Phayao iDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand jSchool of Pharmacy, University of Wisconsin, Madison, USA kAsian Centre for Evidence Synthesis in Population, Implementation and Clinical Outcomes (PICO), Health and Well-being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
    Background: Protective effects of calcium supplementation against colorectal adenomas have been documented in systematic reviews; however, the results have not been conclusive. Our objective was to update and systematically evaluate the evidence for calcium supplementation taking into consideration the risks of systematic and random error and to GRADE the evidence.

    Methods: The study comprised a systematic review with meta-analysis and trial sequential analysis (TSA) of randomized controlled trials (RCTs). Read More

    Clinicopathological features, surgical treatments, and survival outcomes of patients with small bowel adenocarcinoma.
    Medicine (Baltimore) 2017 Aug;96(31):e7713
    aDepartment of Pancreatic and Gastric Surgery bState Key Laboratory of Molecular Oncology cDepartment of Clinical Laboratory, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China dDepartment of Biotherapy, Beijing Hospital, National Center of Gerontology, Beijing, China.
    To date, because of their rarity, the clinicopathological features and surgical outcomes of small bowel adenocarcinomas (SBAs) have been insufficiently explored. We evaluated the clinicopathological features and long-term outcomes of patients who underwent surgery for SBA.This retrospective study (from 1999 to 2016) examined patients with SBA treated surgically at the China National Cancer Center/Cancer Hospital. Read More

    The impact of host's genetic susceptibility on Helicobacter pylori infection in children.
    Medicine (Baltimore) 2017 Jul;96(30):e7612
    aDepartment of Pediatrics, University of Medicine and Pharmacy Tîrgu Mureş bDepartment of Epidemiology, University of Medicine and Pharmacy Tîrgu Mureş cGenetics Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine and Pharmacy Tîrgu Mureş, Romania.
    The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. Read More

    S-1 monotherapy versus S-1 combination therapy in gemcitabine-refractory advanced pancreatic cancer: A meta-analysis (PRISMA) of randomized control trials.
    Medicine (Baltimore) 2017 Jul;96(30):e7611
    aDepartment of Neurosurgery, the First Hospital of Jilin University bClinical College, Jilin University, Changchun, China cDepartment of the Radiotherapy, Hebei University Affiliated Hospital, Baoding dPublic Health College, Jilin University eBasic Medical College, Qiqihar Medical University, Qiqihar fRadiology Department, Jixi Mining General Hospital, Jixi gHepatopancreatobiliary Medicine Department, the First Hospital of Jilin University, Changchun, China.
    Background: Pancreatic cancer (PC) is one of the most lethal digestive system tumors. Most new cases are diagnosed based on metastasis or local aggression and are known as "advanced PC." Recently, studies investigating S-1 have indicated that it has a better clinical curative effect on PC. Read More

    Community burden of undiagnosed HIV infection among adolescents in Zimbabwe following primary healthcare-based provider-initiated HIV testing and counselling: A cross-sectional survey.
    PLoS Med 2017 Jul 25;14(7):e1002360. Epub 2017 Jul 25.
    Biomedical Research and Training Institute, Harare, Zimbabwe.
    Background: Children living with HIV who are not diagnosed in infancy often remain undiagnosed until they present with advanced disease. Provider-initiated testing and counselling (PITC) in health facilities is recommended for high-HIV-prevalence settings, but it is unclear whether this approach is sufficient to achieve universal coverage of HIV testing. We aimed to investigate the change in community burden of undiagnosed HIV infection among older children and adolescents following implementation of PITC in Harare, Zimbabwe. Read More

    Increased nuchal translucency in fetuses with a normal karyotype-diagnosis and management: An observational study.
    Medicine (Baltimore) 2017 Jul;96(29):e7521
    aDepartment of Mother and Child Medicine, University of Medicine and Pharmacy Gr. T. Popa Iasi bHospital of Obstetrics and Gynecology Elena Doamna-Iasi cHuman Genetics Department, University of Medicine and Pharmacy Gr. T. Popa Iasi dUniversity of Medicine and Pharmacy Carol Davila-Bucharest, Romania.
    The use of nuchal translucency (NT) in 1992 by Nicolaides et al was a major breakthrough in screening for chromosomal aneuploidies at the end of the first trimester. However, pathological conditions other than chromosomal aneuploidies are also associated with increased NT, which can also be detected in normal fetuses. This study sought to evaluate the causes of this ultrasound sign in a group of patients from Iasi, Romania. Read More

    Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study.
    BMC Med 2017 Jul 13;15(1):115. Epub 2017 Jul 13.
    Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom.
    Background: The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of and death from prostate cancer in 141,896 men in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

    Methods: Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Read More

    Multiple pedicled flaps cover for large defects following resection of malignant tumors with partition concept.
    Medicine (Baltimore) 2017 Jul;96(27):e7455
    Department of Plastic Surgery, Sun Yat-sen Memorial Hosptial, Sun Yat-sen University, Guangdong Province, China.
    Large defects after skin malignant tumors resection were difficult to repair. We introduced a partition concept, in which the large defects were divided into several subunits, and each subunit was repaired by a certain pedicled flap to achieve a complete coverage.Between May 2012 and Oct 2016, 8 patients with skin malignant tumors underwent radical resection. Read More

    Overall evaluation of the clinical value of prenatal screening for fetal-free DNA in maternal blood.
    Medicine (Baltimore) 2017 Jul;96(27):e7114
    Changzhou Woman and Children Health Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu, China.
    Objective: To explore the clinical value of prenatal screening for fetal-free DNA in maternal blood.

    Methods: A total of 10,275 maternal blood samples were collected from October 2012 to May 2016 at the prenatal diagnosis center of Changzhou Woman and Children Health Hospital.

    Results: Among 10,275 pregnant women accepted noninvasive prenatal testing (NIPT), 9 cases could not get the results after collected the blood second times. Read More

    Multimorbidity and polypharmacy in diabetic patients with NAFLD: Implications for disease severity and management.
    Medicine (Baltimore) 2017 Jun;96(26):e6761
    aDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital bCentre for Liver Disease Research, Translational Research Institute, School of Medicine, The University of Queensland cSchool of Medicine, The University of Queensland dPharmacy Department, Princess Alexandra Hospital eInala Primary Care fPathology Queensland gDepartment of Radiology, Princess Alexandra Hospital hQIMR Berghofer Medical Research Institute iDepartment of Endocrinology, Princess Alexandra Hospital, Brisbane, Australia.
    An observational study describing the number and type of chronic conditions and medications taken by diabetic patients with NAFLD and identifying characteristics that may impact liver disease severity or clinical management.Adults with type 2 diabetes have a high prevalence of nonalcoholic fatty liver disease (NAFLD) and increased risk of developing advanced liver disease. Appropriate management should consider the characteristics of the diabetic NAFLD population, as comorbid conditions and medications may increase the complexity of treatment strategies. Read More

    Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer.
    BMC Med 2017 Jun 26;15(1):118. Epub 2017 Jun 26.
    MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
    Background: Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable investment in molecular risk stratification has sought to overcome the performance ceiling encountered by methods restricted to traditional clinical parameters. However, replication of results has proven challenging, and intratumoural heterogeneity (ITH) may confound attempts at tissue-based stratification. Read More

    Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer.
    BMC Med 2017 Jun 23;15(1):116. Epub 2017 Jun 23.
    Department of Gynecologic Oncology, Cancer Research Center Groningen, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.
    Background: Despite an early response to platinum-based chemotherapy in advanced stage high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug-resistant disease. Aberrant epigenetic alterations like DNA methylation are common in HGSOC. Differences in DNA methylation are associated with chemoresponse in these patients. Read More

    Prognostic impact of Ki-67 in patients with gastric cancer-the importance of depth of invasion and histologic differentiation.
    Medicine (Baltimore) 2017 Jun;96(25):e7181
    aDepartment of Pathology bDepartment of Internal Medicine cDepartment of Surgery, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
    Ki-67 protein is a cellular marker for proliferation. The role of Ki-67 as a prognostic biomarker has not been established in gastric cancer. The present study was performed to investigate the significance of Ki-67 expression as a biomarker in early gastric cancer (EGC). Read More

    Clinical significance of plasma D-dimer in ovarian cancer: A meta-analysis.
    Medicine (Baltimore) 2017 Jun;96(25):e7062
    aNantong Maternity and Child Health Care Hospital, Nantong bNanjing Maternity and Child Health Medical Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing cDepartment of Obstetrics and Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.
    Background: D-dimer has been widely used for the diagnosis and prognosis of ovarian cancer, but there is still controversy on its prediction value of ovarian cancer.

    Objectives: To explore the clinical significance of plasma D-dimer level on ovarian cancer systematically.

    Methods: Using PubMed, Cochrane Library, and Web of Science libraries, all the relevant studies for the diagnostic and prognostic value of plasma D-dimer for ovarian cancer and the relationship between elevated D-dimer level and venous thromboembolism (VTE) risk of ovarian cancer were searched till May 30, 2016. Read More

    Validity of a minimally invasive autopsy tool for cause of death determination in pediatric deaths in Mozambique: An observational study.
    PLoS Med 2017 Jun 20;14(6):e1002317. Epub 2017 Jun 20.
    ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain.
    Background: In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually in low- and middle-income countries remains poor, partly because of the inadequacy and reduced precision of the methods currently utilized in these settings to investigate causes of death (CoDs). The study objective was to validate the use of a minimally invasive autopsy (MIA) approach as an adequate and more acceptable substitute for the complete diagnostic autopsy (CDA) for pediatric CoD investigation in a poor setting. Read More

    Validity of a minimally invasive autopsy for cause of death determination in stillborn babies and neonates in Mozambique: An observational study.
    PLoS Med 2017 Jun 20;14(6):e1002318. Epub 2017 Jun 20.
    ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain.
    Background: Over 5 million stillbirths and neonatal deaths occur annually. Limited and imprecise information on the cause of these deaths hampers progress in achieving global health targets. Complete diagnostic autopsies (CDAs)-the gold standard for cause of death determination-are difficult to perform in most high-burden settings. Read More

    Lymph node metastasis characteristics of papillary thyroid carcinoma located in the isthmus: A single-center analysis.
    Medicine (Baltimore) 2017 Jun;96(24):e7143
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China.
    The frequency and pattern of lymph node metastasis and the extent of dissection for isthmic papillary thyroid carcinoma (PTC) remain unclear, and the aim of this present study was to evaluate these characteristics and to attempt to detect the best surgical protocol for isthmic PTCs. A total of 3185 consecutive patients with PTCs were reviewed. Of these patients, 47 with a single isthmic PTC were enrolled in our study, and matched 47 patients with a single PTC located in the unilateral lobe were randomly selected and added for comparison of their baseline tumor characteristics and lymph node metastasis characteristics. Read More

    Effects of branched-chain amino acids (BCAAs) on the progression of advanced liver disease: A Korean nationwide, multicenter, retrospective, observational, cohort study.
    Medicine (Baltimore) 2017 Jun;96(24):e6580
    aDepartment of Internal Medicine, College of Medicine, Yeungnam University bDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu cDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea dDepartment of Internal Medicine, College of Medicine, Soonchunhyang University eDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul fDepartment of Internal Medicine, Ilsan Paik Hospital, College of Medicine, Inje University College of Medicine, Goyang gDepartment of Internal Medicine, College of Medicine, Hallym University, Chuncheon hDepartment of Internal Medicine, School of Medicine, Chonbuk National University, Chungju iDepartment of Internal Medicine, School of Medicine, Keimyung University, Daegu jDepartment of Internal Medicine, College of Medicine, Dongguk University, Gyeongju kDepartment of Internal Medicine, School of Medicine, Pusan National University, Pusan lMedical Research Collabration Center in KNUH and School of Medicine, Kyungpook National University, Daegu, Korea.
    Evidence of the potential benefits of long-term oral branched-chain amino acid (BCAA) supplementation in reducing the severity of liver disease is limited.Patients who were diagnosed with liver cirrhosis with a Child-Pugh (CP) score of 8-10 were included. The BCAA group consumed BCAAs daily for at least 6 months, and the control group consumed a diet without BCAA. Read More

    Clinicopathological and prognostic significance of homeobox transcript antisense RNA expression in various cancers: A meta-analysis.
    Medicine (Baltimore) 2017 Jun;96(23):e7084
    aDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, Beijing bSchool of Life Science, University of Science and Technology of China, Hefei cDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
    Background: Increased expression of the homeobox (HOX) transcript antisense RNA (HOTAIR) has been reported in multiple types of malignancies and enhances the proliferation and migration of cancer cells. However, the association between HOTAIR expression and tumor progression and prognosis remains controversial. We performed a meta-analysis to clarify the association between the expression of HOTAIR and the clinicopathological features and prognosis in different cancers. Read More

    Immunotherapy in head and neck cancer: aiming at EXTREME precision.
    BMC Med 2017 Jun 2;15(1):110. Epub 2017 Jun 2.
    Department of Medical Oncology, Antwerp University Hospital, Edegem, Belgium.
    Background: Locoregionally advanced, recurrent, and metastatic squamous cell carcinomas of the head and neck (SCCHN) remain difficult to treat disease entities, in which systemic treatment often forms an integral part of their management. Immunotherapy is based on functional restoration of the host immune system, helping to counteract various tumour evasion strategies. Broadly, immunotherapeutic approaches encompass tumour-specific antibodies, cancer vaccines, cytokines, adoptive T-cell transfer, and immune-modulating agents. Read More

    Surgery of the primary tumor improves survival in women with stage IV breast cancer in Southwest China: A retrospective analysis.
    Medicine (Baltimore) 2017 Jun;96(22):e7048
    aCancer Center bLaboratory of Molecular Diagnosis of Cancer, State Key Laboratory of Biotherapy, National Collaborative Innovation Center for Biotherapy cState Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu dDepartments of Anesthesiology, Mianyang Central Hospital, Mianyang, Sichuan, China.
    The International Consensus Guidelines for advanced breast cancer (ABC) considers that the surgery of the primary tumor for stage IV breast cancer patients does not usually improve the survival. However, studies have showed that resection of the primary tumor may benefit these patients. The correlation between surgery and survival remains unclear. Read More

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