569 results match your criteria Advanced Studies in Medicine [Journal]


Enhanced functional connectivity of the default mode network (DMN) in patients with spleen deficiency syndrome: A resting-state fMRI study.

Medicine (Baltimore) 2019 Feb;98(5):e14372

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University.

Numerous studies had investigated the biological basis of spleen deficiency syndrome on gastrointestinal dysfunctions. However, little was known about neuropsychological mechanism of spleen deficiency syndrome. The default model network (DMN) plays an important role in cognitive processing. Read More

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http://dx.doi.org/10.1097/MD.0000000000014372DOI Listing
February 2019

The impact of advanced maternal age on the outcomes of very low birth weight preterm infants.

Medicine (Baltimore) 2019 Feb;98(5):e14336

Department of Neonatology, MacKay Children's Hospital, Taipei.

The association between advanced maternal age and neonatal outcomes remains controversial. This study attempted to determine the short-term and long-term outcomes of very low birth weight (VLBW, <1500 g) preterm infants, born to mothers of advanced age (≥35 years).In this retrospective cohort study, VLBW infants were divided into the advanced maternal age group and comparison group. Read More

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http://dx.doi.org/10.1097/MD.0000000000014336DOI Listing
February 2019

Efficacy of sorafenib adjuvant therapy in northwestern Chinese patients with non-metastatic renal-cell carcinoma after nephrectomy: A multicenter retrospective study.

Medicine (Baltimore) 2019 Feb;98(5):e14237

Department of Urology, Xijing Hospital, Fourth Military Medical University.

Recent studies have confirmed the efficacy of sorafenib for patients with advanced renal cell carcinoma; however, its efficacy and safety as an adjuvant therapy in patients with non-metastatic and loco-regional renal cell carcinoma after surgery remains controversial. Thus, the aim of the present retrospective study was to evaluate the efficacy of adjuvant sorafenib therapy in such patients from 8 centers in northwestern China that were treated from August 2009 to December 2016.After surgery, the patients (n = 48) received oral sorafenib for 3 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000014237DOI Listing
February 2019
1 Read

Herbal medicine (Hyeolbuchukeo-tang or Xuefu Zhuyu decoction) for treating primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2019 Feb;98(5):e14170

Department of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

Background: Primary dysmenorrhea is a condition characterized by painful menstrual cramps that usually occurs in the absence of any identifiable pathological condition among menstruating women, with the prevalence estimates varying between 45% and 95%. Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as a standard treatment for primary dysmenorrhea; however, the failure rate of NSAIDs is often 20% to 25% and these drugs commonly cause adverse effects. In this review, we investigated the current evidence related to the effectiveness of Xuefu Zhuyu decoction (XZD) or Hyeolbuchukeo-tang, a traditional herbal formula, as a treatment for primary dysmenorrhea. Read More

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http://dx.doi.org/10.1097/MD.0000000000014170DOI Listing
February 2019
1 Read

Significant response of low-dose apatinib monotherapy in brain metastases of triple-negative breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14182

Department of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, P. R. China.

Rationale: The potential efficacy of apatinib in patients with advanced triple-negative breast cancer (TNBC) has been observed in a previous phase II clinical study. However, there is no study to evaluate its efficacy and safety in TNBC patients with brain metastasis (BM). Here we report one case that apatinib exhibited excellent antitumor effects in a breast cancer patient with brain metastasis, with no serious treatment-associated with adverse event. Read More

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http://dx.doi.org/10.1097/MD.0000000000014182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358397PMC
January 2019
1 Read

Pancreatitis cytosorbents (CytoSorb) inflammatory cytokine removal: A Prospective Study (PACIFIC).

Medicine (Baltimore) 2019 Jan;98(4):e13044

Medizinische Klinik I, Kliniken Nordoberpfalz, Klinikum, Weiden, Germany.

Background: Acute pancreatitis (AP) usually has a mild course with a mortality rate below 1%. However, around 10% of patients develop severe AP (SAP) involving extra-pancreatic tissues and other organ systems. The mortality of SAP is around 42%. Read More

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http://dx.doi.org/10.1097/MD.0000000000013044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358351PMC
January 2019
2 Reads

Acupotomy for the treatment of lumbar spinal stenosis: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(3):e14160

Chung-Yeon Central Institute, Gwangju, Republic of Korea.

Introduction: This systematic review protocol describes the methods that will be used to evaluate the efficacy and safety of acupotomy for the treatment of lumbar spinal stenosis.

Methods And Analysis: The following electronic databases will be searched until December 2018 without language or publication status restrictions: five English databases, that is Medline, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Allied and Complementary Medicine Database (AMED), and Cumulative Index to Nursing and Allied Health Literature (CINAHL); three Korean databases, that is Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Service System (RISS), and Korea Citation Index (KCI); and three Chinese databases, that is China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP. Any clinical, randomized controlled trials using acupotomy for lumbar spinal stenosis treatment will be included. Read More

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http://dx.doi.org/10.1097/MD.0000000000014160DOI Listing
January 2019
1 Read

Prognostic value of PD-L1 expression in patients with pancreatic cancer: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Jan;98(3):e14006

Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing 210028, Jiangsu Province, China.

Background: Programmed cell death ligand 1 (PD-L1) expression was reported to be associated with poor prognosis in various solid tumors. However, the prognosis value of PD-L1 in pancreatic cancer remained inconclusive. We performed a meta-analysis to assess the clinical value of PD-L1 as a novel prognostic biomarker of pancreatic cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014006DOI Listing
January 2019
9 Reads

No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study.

PLoS Med 2019 Jan 15;16(1):e1002725. Epub 2019 Jan 15.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Background: Studies have shown strong positive associations between serum urate (SU) levels and chronic kidney disease (CKD) risk; however, whether the relation is causal remains uncertain. We evaluate whether genetic data are consistent with a causal impact of SU level on the risk of CKD and estimated glomerular filtration rate (eGFR).

Methods And Findings: We used Mendelian randomization (MR) methods to evaluate the presence of a causal effect. Read More

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http://dx.plos.org/10.1371/journal.pmed.1002725
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http://dx.doi.org/10.1371/journal.pmed.1002725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333326PMC
January 2019
11 Reads

Musculoskeletal ultrasound: a useful tool for diagnosis of hip developmental dysplasia: One single-center experience.

Medicine (Baltimore) 2019 Jan;98(2):e14081

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mureş, Romania.

Developmental dysplasia of the hip (DDH) is one of the most common congenital abnormalities of the musculoskeletal apparatus in newborns. The aim of this study was to analyze the contribution of ultrasonography in the detection of DDH in newborns and infants, identifying the regional incidence of this pathology in the central area of Romania, emphasizing the risk factors that underlie DDH etiopathogenicity.This article represents a retrospective study of 847 newborns and infants examined in the Imagistic Department of a medical center from the central area of Romania, between January 1 and December 31, 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000014081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336624PMC
January 2019
2 Reads

Acupuncture for pain caused by prostate cancer: Protocol for a systematic review.

Medicine (Baltimore) 2019 Jan;98(2):e13954

Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing.

Background: Prostate cancer is a male malignant tumor disease with high prevalence in recent years. Patients with advanced prostate cancer are more likely to have bone metastasis and strong bone pain, and even lead to pathological fracture, which has a serious impact on the quality of life of patients. Acupuncture has good clinical efficacy in treating pain caused by prostate cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000013954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336609PMC
January 2019
8 Reads

Human papilloma virus identification in ocular surface squamous neoplasia by p16 immunohistochemistry and DNA chip test: A strobe-compliant article.

Medicine (Baltimore) 2019 Jan;98(2):e13944

Department of Ophthalmology and Research Institute of Medical Sciences.

The aim of this study was to identify the association between human papilloma virus (HPV) infection and ocular surface squamous neoplasia (OSSN) using p16 immunohistochemistry (IHC) and deoxyribonucleic acid (DNA) chip test.Thirty-eight patients who underwent surgical excision of OSSN were retrospectively studied using tissue samples. The IHC was performed to assess the expression of p16 and DNA chip test was used to detect 24 HPV serotypes. Read More

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http://dx.doi.org/10.1097/MD.0000000000013944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336645PMC
January 2019

Health system costs for individual and comorbid noncommunicable diseases: An analysis of publicly funded health events from New Zealand.

PLoS Med 2019 Jan 8;16(1):e1002716. Epub 2019 Jan 8.

Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.

Background: There is little systematic assessment of how total health expenditure is distributed across diseases and comorbidities. The objective of this study was to use statistical methods to disaggregate all publicly funded health expenditure by disease and comorbidities in order to answer three research questions: (1) What is health expenditure by disease phase for noncommunicable diseases (NCDs) in New Zealand? (2) Is the cost of having two NCDs more or less than that expected given the independent costs of each NCD? (3) How is total health spending disaggregated by NCDs across age and by sex?

Methods And Findings: We used linked data for all adult New Zealanders for publicly funded events, including hospitalisation, outpatient, pharmaceutical, laboratory testing, and primary care from 1 July 2007 to 30 June 2014. These data include 18. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324792PMC
January 2019
2 Reads

Trigger finger secondary to a neglected flexor tendon rupture.

Medicine (Baltimore) 2019 Jan;98(1):e13980

Department of Orthopedic Surgery, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Chonbuk, Republic of Korea.

Secondary trigger finger caused by trauma to the hand, especially associated with partial flexor tendon rupture, is not a common condition. Thus, the clinical manifestations of these patients are not well-known. The aim of this study is to present secondary trigger finger caused by a neglected partial flexor tendon rupture including discussion of the mechanism and treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000013980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344173PMC
January 2019
2 Reads

Meta-analysis of overall incidence and risk of ALK inhibitors-induced liver toxicities in advanced non-small-cell lung cancer.

Medicine (Baltimore) 2019 Jan;98(1):e13726

Aim: Activation of the anaplastic lymphoma kinase (ALK) gene has been found in several human cancers, including non-small-cell lung cancer (NSCLC). Currently, novel drugs targeting ALK gene have been extensively investigated in NSCLC. However, concerns about ALK inhibitors-induced liver toxicities have been increasing. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901040-0000
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http://dx.doi.org/10.1097/MD.0000000000013726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344205PMC
January 2019
7 Reads

Self-perceived limitations and difficulties by Primary Health Care Physicians to assist emergencies.

Medicine (Baltimore) 2018 Dec;97(52):e13819

The study was aimed to identify the training received in Emergency Medicine by physicians and the limitations and difficulties self-perceived by those physicians to assist in emergencies, as well as to analyze the differences according to the work context.Observational cross-sectional study made by a survey using a self-administered questionnaire to a representative simple random sample (with replacement) of 294 doctors (n) working at the Primary Health Care centers out of the total of 851 doctors (N) that form the staff of physicians of Primary Health Care system of Asturias (Spain).In rural areas, the most frequently mentioned reasons were the lack of practical skills (32. Read More

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http://dx.doi.org/10.1097/MD.0000000000013819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314741PMC
December 2018
1 Read

Staged reconstructive treatment for extensive irregular cicatricial alopecia after burn.

Medicine (Baltimore) 2018 Dec;97(52):e13522

Department of Plastic Surgery, Affiliated Hangzhou First People's Hospital.

For extensive irregular cicatricial alopecia after burn, effective and pleasing restoration of hair-bearing scalp remains challenging. In this article, the authors presented staged reconstructive treatment for extensive irregular cicatricial alopecia with the goal to achieve better and reliable results. A retrospective review of staged reconstructive treatment performed in 16 patients with extensive irregular cicatricial alopecia after burn was conducted. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0000
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http://dx.doi.org/10.1097/MD.0000000000013522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314779PMC
December 2018
4 Reads

Nonsmall cell lung cancer with rare exon 7 p.A289V mutation in the EGFR gene responds to Icotinib treatment: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13809

Department of Clinical Oncology, 901 Hospital of Joint Logistics Support Force (The 105 Hospital of People Liberation Army), Hefei, Anhui, China.

Rationale: Mutation p.A289V involving extracellular region of epidermal growth factor receptor (EGFR) exon 7 has not yet been reported in nonsmall cell lung cancer (NSCLC). Studies have shown p. Read More

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http://dx.doi.org/10.1097/MD.0000000000013809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319919PMC
December 2018
3 Reads

Effect of nerve electrical stimulation for treating chemotherapy-induced nausea and vomiting in patients with advanced gastric cancer: A randomized controlled trial.

Medicine (Baltimore) 2018 Dec;97(51):e13620

Department of Gastroenterology, Yulin No.2 Hospital, Yulin, Shaanxi, China.

Background: This randomized controlled trial evaluated the effectiveness of nerve electrical stimulation (NES) for the treatment of chemotherapy-induced nausea and vomiting (CINV) in patients with advanced gastric cancer (AGC).

Methods: One hundred twenty-four eligible patients with AGC were included in this randomized controlled trial. They were equally divided the NES group and the sham group. Read More

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http://dx.doi.org/10.1097/MD.0000000000013620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319986PMC
December 2018
3 Reads

Clinical effects of mindfulness meditation and cognitive behavioral therapy standardized for insomnia: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(51):e13499

The Institute of Mind Humanities, Wonkwang University, Iksan, Republic of Korea.

Introduction: This systematic review protocol describes the methods that will be used to evaluate the efficacy and safety of mindfulness meditation and cognitive behavioral therapy programs as a psychological intervention for insomnia disorders.

Methods And Analysis: We will search the following 11 electronic databases without language or publication status restrictions: MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, Allied and Complementary Medicine Database, Cumulative Index to Nursing and Allied Health Literature, and PsycARTICLES. Furthermore, we will also search 5 Korean-language databases (Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, Research Information Service System, Korean Medical Database, and Korea Citation Index). Read More

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http://dx.doi.org/10.1097/MD.0000000000013499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320014PMC
December 2018
2 Reads

Upregulated delta-like protein 3 expression is a diagnostic and prognostic marker in endometrial cancer: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(51):e13442

Upregulated delta-like protein 3 (DLL3) functions as a Notch ligand and has been a target for cancer therapy. The present study assessed DLL3 expression as a tumor marker for endometrial cancer.RNA-Seq expression data and clinicopathologic records from 545 patients with endometrial cancer were downloaded from The Cancer Genome Atlas database. Read More

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http://dx.doi.org/10.1097/MD.0000000000013442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320086PMC
December 2018
3 Reads

Utility of power Doppler ultrasonography for detecting forefoot bursae in early rheumatoid arthritis: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13295

Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Rationale: Power Doppler ultrasonography (PDUS) in musculoskeletal ultrasound (MSUS) is a sensitive and reliable method for the assessment of rheumatoid arthritis (RA). The association between ultrasound-detectable forefoot bursae and the development of RA has gained attention. However, a few studies have evaluated the utility of PDUS for examining forefoot bursae in early RA. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0001
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http://dx.doi.org/10.1097/MD.0000000000013295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320102PMC
December 2018
6 Reads

Intensity-modulated radiotherapy combined with sequential cisplatin and fluorouracil chemotherapy for locoregionally advanced nasopharyngeal carcinoma.

Medicine (Baltimore) 2018 Dec;97(50):e13361

Department of Radiation Oncology, Fudan University Shanghai Cancer Center.

To investigate the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) combined with induction-adjuvant cisplatin and fluorouracil (PF) in locoregionally advanced nasopharyngeal carcinoma (NPC).A total of 91 biopsy-proven NPC patients treated with IMRT were retrospectively analyzed. All patients received induction chemotherapy (IC) consisting of cisplatin 25 mg/m2 on day 1 to 3, and 5-Fu 2500 mg/m as an intravenous infusion over 120 hours every 3 weeks for 2 cycles. Read More

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http://dx.doi.org/10.1097/MD.0000000000013361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320135PMC
December 2018
1 Read

Telerehabilitation in individuals with severe acquired brain injury: Rationale, study design, and methodology.

Medicine (Baltimore) 2018 Dec;97(50):e13292

IRCCS Centro Neurolesi Bonino Pulejo.

Background: Severe acquired brain injury (SABI) rehabilitation should be as intensive and long as to allow the patients get the best independence and quality of life (QoL), but facing with the rehabilitation socioeconomic burden. Telerehabilitation (TR) could supply frail subjects requiring long-term rehabilitation.

Methods: A multicenter, prospective, parallel design, single-blind trial will be conducted at the IRCCS Neurolesi Bonino Pulejo (Messina, Italy) and IRCCS Hospital San Camillo (Venice, Italy) involving patients suffering from SABI and requiring home motor and cognitive rehabilitation. Read More

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http://dx.doi.org/10.1097/MD.0000000000013292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320067PMC
December 2018
1 Read

Laparoscopic transabdominal preperitoneal technique versus open surgery with the ULTRAPRO Hernia System for the repair of female primary femoral hernias-an observational retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13575

Department of General Surgery, Linyi People's Hospital, Linyi, Shandong Province, China.

Femoral hernias (FHs), predominantly seen in females, require surgery for cure. To date, surgical repair of primary FHs in female patients with either open surgery or laparoscopic operation has been poorly documented. We retrospectively investigated the treatment of female primary FHs with open surgery using the ULTRAPRO Hernia System (UHS procedure) or the laparoscopic procedure, namely, the transabdominal preperitoneal (TAPP) technique. Read More

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http://dx.doi.org/10.1097/MD.0000000000013575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310592PMC
December 2018
1 Read

Meta-analysis of the prognostic value of long non-coding RNA PVT1 for cancer patients.

Medicine (Baltimore) 2018 Dec;97(49):e13548

Department of Orthopedics.

Background: Plasmacytoma variant translocation 1 (PVT1) is reported to be dysregulated in various cancers. Therefore, this meta-analysis was performed to clarify its utility as a prognosis marker in malignant tumors.

Methods: Electronic databases, including PubMed, OVID, Cochrane Library, and Web of Science databases, were retrieved from inception to December 16, 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000013548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310588PMC
December 2018
8 Reads

The impact of lymphovascular invasion in patients with prostate cancer following radical prostatectomy and its association with their clinicopathological features: An updated PRISMA-compliant systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13537

Department of Urology, Affiliated Jiang-yin Hospital of the Southeast University Medical College, Jiang-yin, Jiangsu Province, China.

Objective: Numerous studies have shown that lymphovascular invasion (LVI) is linked to biochemical recurrence (BCR) in prostate cancer (PCa) patients following radical prostatectomy (RP). However, the actual clinicopathological impacts of LVI remain unclear. Thus, we performed a meta-analysis to evaluate the pathologic and prognostic impacts of LVI in PCa patients. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812070-0009
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http://dx.doi.org/10.1097/MD.0000000000013537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310490PMC
December 2018
11 Reads

Prognostic significance of the degree of lymphatic vessel invasion in locally advanced, surgically resectable pancreatic head cancer: A single center experience.

Medicine (Baltimore) 2018 Dec;97(49):e13466

Department of Diagnostic Pathology, Jichi Medical University Hospital.

Little is known concerning the prognostic significance of the degree of lymphatic vessel invasion in pancreatic head cancer. To address this gap in knowledge, we retrospectively examined 60 patients with locally advanced, surgically resectable pancreatic head cancer who underwent pancreaticoduodenectomy and lymph node (LN) dissection.All cases were histopathologically diagnosed as ductal adenocarcinoma, stage II (25 pT3N0 cases, 35 pT3N1 cases). Read More

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http://dx.doi.org/10.1097/MD.0000000000013466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310507PMC
December 2018
1 Read

Baseline 18F-FDG PET/CT as predictor of the pathological response to neoadjuvant therapy in esophageal cancer: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13412

Department of Nuclear Medicine, Rabin Medical Center, Beilinson Hospital.

The type of pathological response to neoadjuvant chemoradiation in patients with locally advanced esophageal cancer predicts overall survival (OS).We aimed to assess early 18F-FDG positron emission tomography/computed tomography parameters in predicting the pathological response to neoadjuvant treatment.The cohort included consecutive patients with locally advanced esophageal cancer who underwent baseline 18F-FDG positron emission tomography/computed tomography between September 2006 and February 2015. Read More

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http://dx.doi.org/10.1097/MD.0000000000013412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310504PMC
December 2018
1 Read

Increased red cell width distribution to lymphocyte ratio is a predictor of histologic severity in primary biliary cholangitis.

Medicine (Baltimore) 2018 Nov;97(48):e13431

Department of Hepatology, First Hospital of Jilin University, Jilin University.

Primary biliary cholangitis (PBC) is a chronic disease that is increasingly being recognized in recent years. In this study, we sought to identify noninvasive markers of the severity of cirrhosis in patients with PBC based on routinely investigated laboratory parameters.Ninety-four patients with histologically-confirmed PBC based on liver biopsy performed between January 2013 and December 2017 at the First Hospital of Jilin University were divided into 2 groups: early-stage cirrhosis (fibrosis stage F1 and F2; n = 74) and advanced-stage cirrhosis (fibrosis stage F3 and F4; n = 20). Read More

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http://dx.doi.org/10.1097/MD.0000000000013431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283214PMC
November 2018
2 Reads

LncRNA PCAT-1 in gastrointestinal cancers: A meta-analysis.

Authors:
Wanwei Liu Jiwei Xu

Medicine (Baltimore) 2018 Nov;97(48):e13429

Background: Prostate-cancer-associated ncRNA transcript 1 (PCAT-1), a newly discovered lncRNA, was implicated in the progression of multiple tumors. We conducted a systematic review and meta-analysis to determine its prognostic potential for gastrointestinal cancers.

Methods: A literature survey was conducted by searching the PubMed, Web of Science, Cochrane Library, Embase together with Wanfang, and China National Knowledge Infrastructure (CNKI) database for articles published as of October 15, 2017. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811300-0007
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http://dx.doi.org/10.1097/MD.0000000000013429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283125PMC
November 2018
9 Reads

Sarcopenia is poor prognostic factor in older patients with locally advanced rectal cancer who received preoperative or postoperative chemoradiotherapy.

Medicine (Baltimore) 2018 Nov;97(48):e13363

Department of Radiation Oncology, Chung-Ang University College of Medicine, Seoul, South Korea.

Sarcopenia is associated with low muscle mass and low physical performance. Here, we performed to evaluate the sarcopenia as prognostic factor and treatment outcomes in older patients with locally advanced rectal cancer (LARC) who received preoperative or postoperative chemoradiotherapy (CRT).LARC patients aged ≥65 years who received either preoperative or postoperative CRT were analyzed retrospectively. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811300-0004
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http://dx.doi.org/10.1097/MD.0000000000013363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283099PMC
November 2018
6 Reads

Long-term results of vascularized os pisiform transfer for advanced Kienböck disease after follow-up for at least 15 years: A case series.

Medicine (Baltimore) 2018 Nov;97(48):e13229

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

No surgical procedure perfectly treats advanced Kienböck disease. Although vascularized os pisiform transferring (VOPT) is one of the main therapeutic approaches, reports on long-term follow-up and case series for this technique are scarce.We collected postoperative results in 11 patients with advanced Kienböck disease who underwent VOPT between 1986 and 2001 in our Hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000013229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283118PMC
November 2018
2 Reads

Enhancing the prediction of acute kidney injury risk after percutaneous coronary intervention using machine learning techniques: A retrospective cohort study.

PLoS Med 2018 Nov 27;15(11):e1002703. Epub 2018 Nov 27.

Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut, United States of America.

Background: The current acute kidney injury (AKI) risk prediction model for patients undergoing percutaneous coronary intervention (PCI) from the American College of Cardiology (ACC) National Cardiovascular Data Registry (NCDR) employed regression techniques. This study aimed to evaluate whether models using machine learning techniques could significantly improve AKI risk prediction after PCI.

Methods And Findings: We used the same cohort and candidate variables used to develop the current NCDR CathPCI Registry AKI model, including 947,091 patients who underwent PCI procedures between June 1, 2009, and June 30, 2011. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258473PMC
November 2018
8 Reads

Prognostic value of pretreatment serum lactate dehydrogenase level in pancreatic cancer patients: A meta-analysis of 18 observational studies.

Medicine (Baltimore) 2018 Nov;97(46):e13151

Department of General Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.

Background: Several studies were conducted to investigate the prognostic value of pretreatment serum lactate dehydrogenase (LDH) level in pancreatic cancer (PC), but the results were inconsistent. This study aims to comprehensively assess the prognostic value of pretreatment serum LDH level in PC patients by combining the data of the published literatures on this topic.

Methods: Embase, PubMed, and Web of Science were completely retrieved until June, 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000013151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257391PMC
November 2018
1 Read

Postoperative morbidity and mortality in patients receiving neoadjuvant chemotherapy for locally advanced gastric cancers: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Oct;97(43):e12932

Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Guangxi Autonomous Region, China.

Aim: To investigate the postoperative morbidity and mortality for neoadjuvant chemotherapy (NAC) plus surgery compared with surgery alone.

Methods: PubMed and Embase were searched to capture the incidence of any postoperative complications, pulmonary complications, anastomotic leakage, surgical site infections, and postoperative mortality in randomized clinical trials comparing NAC plus surgery with surgery alone. The meta-analyses were performed with a random effects model. Read More

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http://dx.doi.org/10.1097/MD.0000000000012932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221738PMC
October 2018
12 Reads

The value of magnetic resonance imaging to diagnose pathological complete response of rectal cancer after therapy: A protocol for meta-analysis.

Medicine (Baltimore) 2018 Oct;97(43):e12901

Gansu Provincial Hospital, Lanzhou, China.

Background: Although the trends of colorectal incidence rate and mortality have decreased during the past 20 years, however, they are still high. Neoadjuvant chemoradiotherapy is recommended as the standard treatment strategy of local advanced rectal cancer followed by surgery and adjuvant therapy. Predicting pathological complete response (pCR) accurately is relative to the next treatment strategy to avoid extensive therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000012901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221727PMC
October 2018
8 Reads

Age-related variations in corneal geometry and their association with astigmatism: The Yamagata Study (Funagata).

Medicine (Baltimore) 2018 Oct;97(43):e12894

Department of Ophthalmology and Visual Sciences.

To investigate how aging affects corneal geometry in Japanese adults, and the association between corneal geometry and astigmatism.We included 421 participants who had undergone systemic and ophthalmological examinations in 2015 in Funagata town, Yamagata, Japan. Corneal topographic data were obtained using anterior-segment optical coherence tomography (CASIA SS-1000). Read More

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http://dx.doi.org/10.1097/MD.0000000000012894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221551PMC
October 2018
11 Reads

Factors predicting adjacent segment disease after anterior cervical discectomy and fusion treating cervical spondylotic myelopathy: A retrospective study with 5-year follow-up.

Medicine (Baltimore) 2018 Oct;97(43):e12893

Department of Orthopaedics, Affliated Hospital of Hebei University, Baoding.

The purpose of this study is to explore perioperative factors predicting symptomatic adjacent segment disease (ASD) after anterior cervical discectomy and fusion (ACDF) for patients with cervical spondylotic myelopathy (CSM) at 5-year follow-up.This study included 356 patients who underwent ACDF for CSM from Jan.2011 to Jan. Read More

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http://dx.doi.org/10.1097/MD.0000000000012893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221637PMC
October 2018
8 Reads

Clinical signs of retroperitoneal abscess from colonic perforation: Two case reports and literature review.

Medicine (Baltimore) 2018 Nov;97(45):e13176

Department and Clinic of Gastrointestinal and General Surgery, Medical University, Wroclaw. Poland.

Rationale: Retroperitoneal colonic perforation is a rare cause of retroperitoneal abscess. It presents, more frequently in frail elderly patients, with heterogeneous signs and symptoms which hamper the clinical diagnosis. Subcutaneous emphysema with pneumomediastinum and iliopsoas muscle abscess are unusual signs. Read More

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http://dx.doi.org/10.1097/MD.0000000000013176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250550PMC
November 2018
11 Reads

Prognostic value of the systematic immune-inflammation index among patients with operable colon cancer: A retrospective study.

Medicine (Baltimore) 2018 Nov;97(45):e13156

Department of Gastroenterology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu Province, China.

The systematic immune-inflammation index (SII) has been used to predict the prognosis of patients with various cancers. This study aimed to determine whether the preoperative SII was associated with postoperative survival among patients with operable colon cancer.This retrospective study included 118 age- and sex-matched healthy subjects and 118 patients who underwent radical surgery for colon cancer between January 2011 and December 2013. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0006
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http://dx.doi.org/10.1097/MD.0000000000013156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250528PMC
November 2018
19 Reads

Propranolol eye drops in patients with corneal neovascularization.

Medicine (Baltimore) 2018 Nov;97(45):e13002

Pediatric Ophthalmology Unit, Niguarda Ca' Granda Metropolitan Hospital, Milan, Italy.

Rationale: Studies performed in animal models of corneal neovascularization suggested the possible efficacy of a treatment with propranolol. Corneal neovascularization is one of the most feared complications of Stevens-Johnson syndrome that frequently involves ocular surface. We report the first 2 patients with severe ocular neo-vascularization treated with different degrees of success, with propranolol eye drops. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0001
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http://dx.doi.org/10.1097/MD.0000000000013002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250516PMC
November 2018
15 Reads

XRCC1 polymorphism and overall survival in ovarian cancer patients treated with platinum-based chemotherapy: A systematic review and MOOSE-compliant meta-analysis.

Medicine (Baltimore) 2018 Nov;97(45):e12996

Department of Pharmacy, Peking University First Hospital, Beijing, China.

Objectives: Although platinum-based chemotherapy is widely used for advanced ovarian cancer (OC), genetic polymorphisms can influence the chemotherapeutic response. This study investigated the association between XRCC1 polymorphisms Arg194Trp, Arg280His, and Arg399Gln, and overall survival (OS) in OC patients who received platinum-based chemotherapy.

Methods: We systematically searched PubMed, Embase, the Cochrane library, Chinese National Knowledge Infrastructure, Wanfang, and Weipu databases for relevant studies from inception to October, 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000012996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250521PMC
November 2018
8 Reads

Determinants of the urinary and serum metabolome in children from six European populations.

BMC Med 2018 Nov 8;16(1):202. Epub 2018 Nov 8.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK.

Background: Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environment-health interactions. However, large-scale metabolome studies in children combining analyses of these biological fluids are lacking. Read More

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https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291
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http://dx.doi.org/10.1186/s12916-018-1190-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223046PMC
November 2018
9 Reads

The prognostic value of lymph node ratio for local advanced gastric cancer patients with adjuvant chemoradiotherapy after D2 gastrectomy.

Medicine (Baltimore) 2018 Nov;97(44):e13079

State Key Laboratory of Biotherapy, Cancer Center.

This study aimed to find the prognostic factors of local advanced gastric cancer patients with adjuvant concurrent chemoradiotherapy after radical D2 gastrectomy, and explore the prognostic value of lymph node ratio (LNR).We retrospectively analyzed 164 gastric cancer patients enrolled in West China Hospital from 2006 to 2013, who underwent D2 radical gastrectomy and adjuvant chemoradiotherapy. With univariate analysis and the Cox regression model, we evaluated the association of LNR and other clinical pathological characteristics with overall survival (OS) and relapse-free survival (RFS) of patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000013079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221689PMC
November 2018
3 Reads
5.723 Impact Factor

Intra-arterial chemotherapy for unilateral advanced intraocular retinoblastoma: Results and short-term complications.

Medicine (Baltimore) 2018 Oct;97(42):e12676

Department of Interventional Radiology and hemangioma.

Intra-arterial chemotherapy (IAC) has become an essential technique for the management of advanced intraocular retinoblastoma (RB). In this study, the aim of this article is to describe the clinical results and the short-term complications of IAC performed in our hospital.We retrospectively analyzed patients with newly diagnosed unilateral advanced intraocular (group D or E) RB undergoing IAC from October 2016 to December 2017 in our hospital. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810190-0001
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http://dx.doi.org/10.1097/MD.0000000000012676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211923PMC
October 2018
6 Reads
5.720 Impact Factor

Safety and efficacy of combining capecitabine and temozolomide (CAPTEM) to treat advanced neuroendocrine neoplasms: A meta-analysis.

Medicine (Baltimore) 2018 Oct;97(41):e12784

Tianjin Medical University General Hospital, Tianjin, P.R. China.

Retrospective studies have suggested that capecitabine combined with temozolomide (CAPTEM) is effective for treating patients with advanced neuroendocrine neoplasms (NENs); however, the efficacy and safety of this regimen needs to be verified by high-quality evidence or results of randomized controlled trials.We carried out a meta-analysis to evaluate the safety and effectiveness of a CAPTEM protocol for patients with advanced NENs. Systematic electronic literature searches were conducted using PubMed, EMBASE, and the Cochrane Library, and among meeting abstracts of the American Society of Clinical Oncology, European Society for Medical Oncology, European Neuroendocrine Tumor Society, and North American Neuroendocrine Tumor Society, up to June 30, 2017. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810120-0008
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http://dx.doi.org/10.1097/MD.0000000000012784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203503PMC
October 2018
3 Reads

A model predicting short-term mortality in patients with advanced liver cirrhosis and concomitant infection.

Medicine (Baltimore) 2018 Oct;97(41):e12758

Department of Hepatology and Gastroenterology, Tianjin Third Central Hospital Affiliated to Tianjin Medical University, Tianjin Key Laboratory of Artificial Cells, Tianjin, China.

Infection is a common cause of death in patients with advanced cirrhosis. We aimed to develop a predictive model in Child-Turcotte-Pugh (CTP) class C cirrhotics hospitalized with infection for optimizing treatment and improving outcomes.Clinical information was retrospectively abstracted from 244 patients at Tianjin Third Central Hospital, China (cohort 1). Read More

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http://Insights.ovid.com/crossref?an=00005792-201810120-0006
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000012758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203558PMC
October 2018
6 Reads
5.723 Impact Factor

Acupuncture for treating whiplash-associated disorder: A systematic review and meta-analysis protocol.

Medicine (Baltimore) 2018 Oct;97(41):e12654

Department of Acupuncture & Moxibustion, School of Korean Medicine, Pusan National University, Yangsan, South Korea.

Background: This review aims to evaluate the effectiveness and safety of acupuncture treatment for patients with whiplash-associated disorder (WAD).

Methods: We will search the following databases from their inception to October 2018: MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature, the Allied and Complementary Medicine Database, 1 Chinese database (China National Knowledge Infrastructure), 1 Japanese database (Japan Science and Technology Information Aggregator, Electronic), and 5 Korean databases (KoreaMed, Research Information Service System, Korean Studies Information Service System, Database Periodical Information Academic, and Oriental Medicine Advanced Searching Integrated System). All randomized controlled trials of acupuncture for WAD will be considered for inclusion without language restrictions. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810120-0003
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000012654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203494PMC
October 2018
2 Reads

Herbal medicine Yukgunja-tang for functional dyspepsia protocol for a systematic review of randomized controlled trials.

Medicine (Baltimore) 2018 Oct;97(40):e12555

Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Background: Functional dyspepsia (FD) is a common functional gastrointestinal disorder characterized by recurrent dyspeptic symptoms. Yukgunja-tang (YGT) is a traditional herbal formula that has been used for treating FD. This systematic review protocol aims to provide a guideline for investigating the efficacy and safety of YGT in the treatment of FD. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810050-0002
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000012555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200529PMC
October 2018
2 Reads