788 results match your criteria Advanced Studies in Medicine [Journal]


Effect of advanced nursing care on psychological disorder in patients with COVID-19: A protocol of systematic review.

Medicine (Baltimore) 2020 Jul;99(27):e21026

Department of Nursing Care, Yan'an People's Hospital, Yan'an, China.

Background: This study will explore the effect of advanced nursing care (ANC) on psychological disorder (PD) in patients with Coronavirus Disease 2019 (COVID-19).

Methods: This study will search the following electronic databases up to June 30, 2020: Cochrane Library, PUBMED, EMBASE, PsycINFO, Web of Science, OpenGrey, Cumulative Index to Nursing and Allied Health Literature, CNKI, and WANGFANG. We will not impose any language limitations. Read More

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http://dx.doi.org/10.1097/MD.0000000000021026DOI Listing

Xiaoaiping injection as adjunct therapy for patients with advanced esophageal carcinoma: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20984

Department of General Surgery, People's Hospital of Weifang Binhai Economic and Technological Development Zone, Weifang, Shandong Province, China.

Background: Esophageal carcinoma (EC) is one of the worst malignant digestive neoplasms with a strong tendency of invasion and metastasis. Despite the improvement of diagnostic and therapeutic methods in the past decades, the prognosis of EC remains unsatisfactory. Xiaoaiping injection (XAPI), a famous traditional Chinese herbal medicine, has been widely applied as a promising adjunctive drug for EC. Read More

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http://dx.doi.org/10.1097/MD.0000000000020984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328972PMC

Phase 1 clinical study of cell therapy with effective-mononuclear cells (E-MNC) for radiogenic xerostomia (first-in-human study) (FIH study on E-MNC therapy for radiogenic xerostomia).

Medicine (Baltimore) 2020 Jun;99(26):e20788

Department of Regenerative Oral Surgery, Unit of Translational Medicine.

Background: Treatment for most patients with head and neck cancers includes ionizing radiation with or without chemotherapy. This treatment causes irreversible damage to salivary glands in the irradiation field accompanied by a loss of fluid-secreting acinar cells and a considerable decrease of saliva secretion. There is currently no adequate conventional treatment for this condition. Read More

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http://dx.doi.org/10.1097/MD.0000000000020788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328916PMC

Effects of hepatic arterial infusion chemotherapy in the treatment of hepatocellular carcinoma: A meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20745

Hepatic Biliary Pancreatic Surgery Department, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan, China.

Background: The potential benefits and safety of hepatic arterial infusion chemotherapy (HAIC) for the treatment of patients with hepatocellular carcinoma (HCC) remains inconsistent. Therefore, we conducted this meta-analysis of evaluate the efficacy and safety of HAIC in the treatment of HCC.

Methods: A comprehensive literature search was performed using PubMed, Embase, Web of Science, and the Cochrane library to identify eligible studies that compared HAIC with other therapies for patients with HCC. Read More

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http://dx.doi.org/10.1097/MD.0000000000020745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328911PMC

Efficacy and safety of paclitaxel with or without targeted therapy as second-line therapy in advanced gastric cancer: A meta-analysis.

Medicine (Baltimore) 2020 Jun;99(25):e20734

Department of Oncology.

Backgroud: Paclitaxel (PTX) has become a widely used second-line therapy for advanced gastric cancer. There exists controversy whether targeted therapy combined with PTX can provide additional benefit over PTX alone. Therefore, a meta-analysis was carried out to evaluate the efficacy and safety of the two therapy regimes. Read More

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http://dx.doi.org/10.1097/MD.0000000000020734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310866PMC

Glucocorticoid versus traditional therapy for hepatitis B virus-related acute-on-chronic liver failure: A systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(25):e20604

Infectious Disease Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

Objective: This meta-analysis aimed to assess the efficacy and safety of glucocorticoid versus traditional therapy for hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF).

Methods: PubMed, Cochrane Central Register of Clinical Trials, and EMBASE were searched. All clinical studies, including randomized controlled studies and cohort studies, comparing glucocorticoids with traditional treatments (until November 1, 2018), were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000020604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310991PMC
June 2020
5.723 Impact Factor

A-kinase interacting protein 1 high expression correlates with advanced tumor stage and poor overall survival in surgical patients with clear cell renal cell carcinoma.

Medicine (Baltimore) 2020 Jun;99(24):e20742

Department of Neurology, The Hospital of Bayannaoer, Inner Mongolia Autonomous Rogion, Bayannur, China.

The present study aimed to detect the A-kinase interacting protein 1 (AKIP1) expression in clear cell renal cell carcinoma (ccRCC) tumor tissues and adjacent tissues, and further investigate the correlation of tumor AKIP1 expression with clinicopathological features and survival profile in ccRCC patients.Totally 210 ccRCC patients who underwent resection were retrospectively reviewed, and their tumor and adjacent tissue specimens were acquired for immunohistochemical detection of AKIP1 expression. The survival data of patients were collected for overall survival (OS) assessment. Read More

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http://dx.doi.org/10.1097/MD.0000000000020742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302652PMC

Efficacy and safety of ramucirumab treatment in patients with advanced colorectal cancer: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2020 Jun;99(24):e20618

Department of Radiotherapy, Liaocheng People's Hospital, Liaocheng, Shandong Province, China.

Background: vascular endothelial growth factor receptor 2 (VEGFR-2) has an important role in colorectal cancer pathogenesis and progression. The aim of our study is to provide a protocol for assessing the efficacy and safety of ramucirumab (a monoclonal antibody VEGFR-2 antagonist) for the treatment of advanced colorectal cancer.

Methods: The systematic review will be reported according to the preferred reporting items for systematic reviews and meta-analyses protocols. Read More

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http://dx.doi.org/10.1097/MD.0000000000020618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302601PMC

Japanese parturient body mass index and the role in initial nerve block height of women undergoing cesarean delivery with spinal anesthesia.

Medicine (Baltimore) 2020 Jun;99(23):e20584

Department of Anesthesiology, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo.

The present retrospective cohort study was designed to determine body mass index (BMI) at the delivery in women undergoing cesarean section in a Japanese urban area, and whether the nerve block height after spinal anesthesia upon the cesarean delivery relates to the lower maternal BMI, less gestational age, or underweight fetus at birth in the population.A total of 401 pregnant women undergoing cesarean delivery with spinal anesthesia were evaluated retrospectively. We examined background differences, including BMI at the delivery, gestational age, and fetal birth weight between the cases with and without the adequate initial nerve block height less than the sixth thoracic vertebral level (Th6) after the spinal dose administration. Read More

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http://dx.doi.org/10.1097/MD.0000000000020584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306345PMC

Prognostic and clinical implications of c-erbB-2 expression in patients with oral cancer: A meta-analysis.

Medicine (Baltimore) 2020 Jun;99(23):e20575

Department of Stomatology, Liaocheng People's Hospital, Liaocheng City, Shandong Province, China.

Background: Recently, many studies have suggested that the aberrant expression of c-erbB-2 existed in oral cancer (OC) patients and had a correlation with poor clinical features across OC patients. Considering the inconsistent results among published articles, we performed the meta-analysis to assess the prognostic and clinical effect of c-erbB-2 expression on oral tumors.

Methods: Web of Science, Embase, and PubMed were retrieved to acquire relevant publications based on selection criteria, up to February 8, 2020. Read More

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http://dx.doi.org/10.1097/MD.0000000000020575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306320PMC

Chinese patent medicine (Jinlong Capsule) for gastric cancer: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(23):e20532

Quality Management Office, People's Hospital of Weifang Binhai Economic and Technological Development Zone, Weifang, Shandong Province, China.

Background: JLC has been widely applied as a promising adjunctive drug for GC. However, the exact effects and safety of JLC have yet to be systematically investigated. We aimed to summarize the efficacy and safety of JLC for the treatment of advanced GC through the meta-analysis, in order to provide scientific reference for the design of future clinical trials. Read More

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http://dx.doi.org/10.1097/MD.0000000000020532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306397PMC

Effects of tyrosine kinase inhibitor therapy on skin toxicity and skin-related quality of life in patients with lung cancer: An observational study.

Medicine (Baltimore) 2020 Jun;99(23):e20510

School of Nursing, College of Medicine, Chang Gung University.

Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy is the primary treatment option for patients with non-small cell lung cancer (NSCLC). However, one of the major adverse effects associated with this therapy is skin toxicity, which impacts the patient's quality of life. This study aimed to describe the severities and locations of skin toxicity, and to analyze their association with the quality of life in patients with advanced NSCLC who received EGFR-TKI therapy as first-line treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000020510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306373PMC

The prognostic and diagnostic values of MicroRNA-10b in gastric cancer: A comprehensive study based on meta-analysis and TCGA database.

Medicine (Baltimore) 2020 Jun;99(23):e20508

Department of General Practice, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

We conducted a study to evaluate the prognostic and diagnostic values of microRNA-10b (miR-10b) in gastric cancer (GC) based on meta-analysis and TCGA database. Relevant studies were searched in English and Chinese database and meta-analysis was conducted on Stata 12.0. Read More

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http://dx.doi.org/10.1097/MD.0000000000020508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306363PMC

Effect of advanced nursing care on psychological condition in patients with chronic heart failure: A protocol of systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(23):e20355

Department of Cardiothoracic Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Background: This study will appraise the effect and safety of advanced nursing care (ANC) on psychological condition (PC) in patients with chronic heart failure (CHF).

Methods: The following databases will be sought from the beginning up to the February 29, 2020: MEDLINE, EMBASE, Cochrane Library, Web of Science, Scopus, the Cumulative Index to Nursing and Allied Health Literature, the Allied and Complementary Medicine Database, the Chinese Scientific Journal Database, and China National Knowledge Infrastructure. There are not language and publication status limitations related to any electronic databases. Read More

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http://dx.doi.org/10.1097/MD.0000000000020355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306357PMC

Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study.

BMC Med 2020 06 3;18(1):168. Epub 2020 Jun 3.

Departments of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission.

Methods: A multicenter nested case-control study was conducted in four designated hospitals in China enrolling confirmed COVID-19 patients who were mild on admission. Read More

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http://dx.doi.org/10.1186/s12916-020-01633-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268591PMC
June 2020
7.249 Impact Factor

Correlation between peripheral blood inflammatory indicators and pathologic complete response to neoadjuvant chemotherapy in locally advanced breast cancer patients.

Medicine (Baltimore) 2020 May;99(22):e20346

Gazi University, Department of Medical Oncology, Ankara, Turkey.

The immune system plays a fundamental role in the response to neoadjuvant chemotherapy (NAC) of locally advanced breast cancer (LABC) patients. Patients with pathological complete response (pCR) after NAC have a higher survival rate. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are peripheral blood indicators of inflammatory response. Read More

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http://dx.doi.org/10.1097/MD.0000000000020346DOI Listing
May 2020
5.723 Impact Factor

Effect of statins on cardiovascular complications in chronic kidney disease patients: A network meta-analysis.

Medicine (Baltimore) 2020 May;99(22):e20061

Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University School of Medicine, Incheon.

Background: The rates of cardiovascular mortality and morbidity are increased in advanced chronic kidney disease (CKD). Mild to moderate CKD is associated with an increase in cardiovascular events. This study aims to investigate the effects of statins on patient mortality and cardiac events. Read More

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http://dx.doi.org/10.1097/MD.0000000000020061DOI Listing

Utility of neutrophil-to-lymphocyte ratio to identify long-term survivors among HCC patients treated with sorafenib.

Medicine (Baltimore) 2020 May;99(22):e19958

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.

Sorafenib is the first multikinase inhibitor demonstrating a survival benefit for patients suffering from advanced hepatocellular carcinoma (HCC). However, 1 issue remains open: what is the factor able to predict which patients will be long survivors?In the present study, we harnessed the potential of conditional survival, aiming at estimating the probability that a patient receiving sorafenib survives for more than 3 years.The present multicentric study was conducted on a cohort of 438 HCC patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000019958DOI Listing
May 2020
5.723 Impact Factor

Development and validation of 9-long Non-coding RNA signature to predicting survival in hepatocellular carcinoma.

Medicine (Baltimore) 2020 May;99(21):e20422

West China Health Care Hospital of Sichuan University.

Primary hepatic carcinoma is 1 of the most common malignant tumors globally, of which hepatocellular carcinoma (HCC) accounts for 85% to 90%. Due to the high degree of deterioration and low early detection rate of HCC, most patients are diagnosed when they are already in the middle and advanced stages, and the prognosis are always poor.RNA sequencing data from the cancer genome atlas was used to explore differences in lncRNA expression profiles. Read More

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http://dx.doi.org/10.1097/MD.0000000000020422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249897PMC

Rapid platelet count improvement in chronic hepatitis C patients with thrombocytopenia receiving direct-acting antiviral agents.

Medicine (Baltimore) 2020 May;99(19):e20156

Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi.

The effect of direct-acting antiviral agents (DAAs) on short-term platelet improvement in chronic hepatitis C (CHC) patients with thrombocytopenia is unclear.From December 2015 to March 2018, a total of 249 CHC patients receiving DAA treatment with baseline thrombocytopenia (platelet count <150 × 10 /μL) at Dalin Tzu Chi Hospital were enrolled in this retrospective study. Blood examinations were conducted at baseline (BL), week 4 (W4) after DAA initiation, end of treatment (EOT), and 12 weeks after EOT (P12). Read More

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http://dx.doi.org/10.1097/MD.0000000000020156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220127PMC

Relationship between T stage and survival in distantly metastatic esophageal cancer: A STROBE-compliant study.

Medicine (Baltimore) 2020 May;99(19):e20064

Department of Thoracic Surgery, First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, People's Republic of China.

To shed light on the interaction between the American Joint Committee on Cancer (AJCC) T stage and M stage in the determination of the overall survival (OS) and cancer-specific survival (CSS) of esophageal carcinoma patients. Moreover, to confirm our hypothesis that tumors that metastasize to distant sites in the early T stage may reflect a more biologically aggressive disease compared with those that metastasize in more advanced T stages.We performed a retrospective cohort study with patients who were pathologically diagnosed with esophageal cancer between 2004 and 2014 in the surveillance epidemiology and end results (SEER) database. Read More

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http://dx.doi.org/10.1097/MD.0000000000020064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220676PMC

A single-center, retrospective study of COVID-19 features in children: a descriptive investigation.

BMC Med 2020 05 6;18(1):123. Epub 2020 May 6.

Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, No.100 Hongkong Road, Wuhan, 430016, China.

Background: Compared to adults, there are relatively few studies on COVID-19 infection in children, and even less focusing on the unique features of COVID-19 in children in terms of laboratory findings, locations of computerized tomography (CT) lesions, and the role of CT in evaluating clinical recovery. The objective of this study is to report the results from patients at Wuhan Children's Hospital, located within the initial center of the outbreak.

Methods: Clinical, imaging, and laboratory data of 76 children were collected retrospectively and analyzed with the Fisher exact test and Cox regression statistical methods. Read More

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http://dx.doi.org/10.1186/s12916-020-01596-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200209PMC

Metabolic risk factors and incident advanced liver disease in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of population-based observational studies.

PLoS Med 2020 04 30;17(4):e1003100. Epub 2020 Apr 30.

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide. Many individuals have risk factors associated with NAFLD, but the majority do not develop advanced liver disease: cirrhosis, hepatic decompensation, or hepatocellular carcinoma. Identifying people at high risk of experiencing these complications is important in order to prevent disease progression. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192386PMC

Efficacy of cisplatin combined with topotecan in patients with advanced or recurrent ovarian cancer as second- or higher-line palliative chemotherapy.

Medicine (Baltimore) 2020 Apr;99(17):e19931

Department of Internal Medicine.

The aim of this study was to evaluate the outcomes of patients with advanced or recurrent ovarian cancer treated with cisplatin combined with topotecan as second- or higher-line palliative chemotherapy.We retrospectively reviewed the medical records of patients with advanced or recurrent ovarian cancer, who were treated with cisplatin (50 mg/m on day 1) and topotecan (0.75 mg/m on days 1-3). Read More

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http://dx.doi.org/10.1097/MD.0000000000019931DOI Listing

One-year follow-up of heart transplant recipient with cardiac rehabilitation: A case report.

Medicine (Baltimore) 2020 Apr;99(17):e19874

Department of Rehabilitation Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan.

Introduction: Heart transplantation (HT) is known to be the final therapy for patients with advanced heart failure; however, the exercise capacity of these patients remains under the aged-predicted value after HT. Many studies have described the effectiveness and safety of cardiac rehabilitation (CR) in HT recipients. Nevertheless, long-term follow-up data of HT recipients undergoing CR are insufficient, and there is a lack of evidence on the long-term effects of CR. Read More

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http://dx.doi.org/10.1097/MD.0000000000019874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220669PMC

A systematic review and meta-analysis of the efficacy of acupuncture and electroacupuncture against chemotherapy-induced peripheral neuropathy.

Medicine (Baltimore) 2020 Apr;99(17):e19837

Institute for Integrative Medicine, Catholic Kwandong University International St. Mary's Hospital, Incheon, Republic of Korea.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) occurs in 68.1% of patients within the first month of undergoing chemotherapy; however, standardized treatment for CIPN has not been established yet. The efficacy of acupuncture, a widely used treatment for CIPN in South Korea, has not been studied sufficiently. Read More

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http://dx.doi.org/10.1097/MD.0000000000019837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220547PMC

Coats' disease: characteristics, management, outcome, and scleral external drainage with anterior chamber maintainer for stage 3b disease.

Medicine (Baltimore) 2020 Apr;99(16):e19623

Departments of Surgery (Ophthalmology) King Hussein Cancer Center.

To report on the characteristics and outcome of management of Coats' disease, and to describe a novel surgical technique for management of stage 3B with total retinal detachment (RD) by scleral external drainage with anterior chamber (AC-maintainer) placement before the drainage without pars plana vitrectomy.A retrospective study of 26 eyes from 25 Coats' patients. Outcome measures included: demographics, presentation, laterality, stage, treatment, and outcome. Read More

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http://dx.doi.org/10.1097/MD.0000000000019623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220322PMC

Prognostic significance of red blood cell distribution width in gastrointestinal cancers: A meta-analysis.

Medicine (Baltimore) 2020 Apr;99(16):e19588

Department of Hepatobiliary.

Background: Many publications showed red blood cell distribution width (RDW) might associate with the prognosis of gastrointestinal (GI) cancers, however, the agreement has not been reached because of controversial results. This meta-analysis aimed to explore the prognostic value of RDW in GI cancers.

Methods: Four common databases were comprehensively searched to look for relevant studies. Read More

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http://dx.doi.org/10.1097/MD.0000000000019588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220356PMC
April 2020
5.723 Impact Factor

Transcatheter arterial embolization for advanced gastric cancer bleeding: A single-center experience with 58 patients.

Medicine (Baltimore) 2020 Apr;99(15):e19630

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul.

To investigate computed tomography and angiography findings and clinical outcomes after transcatheter arterial embolization for acute upper gastrointestinal bleeding from advanced gastric cancers.From January 2005 to December 2014, 58 patients with pathologically proven gastric cancer were treated at our institution with transcatheter arterial embolization due to acute upper gastrointestinal bleeding recalcitrant to endoscopic treatment. The electronic medical records for each patient were reviewed for clinical presentation, endoscopy history, computed tomography and angiographic findings, blood transfusion requirements, and follow-up results. Read More

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http://dx.doi.org/10.1097/MD.0000000000019630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220502PMC

Comparison of stereotactic body radiation therapy with and without sorafenib as treatment for hepatocellular carcinoma with portal vein tumor thrombosis.

Medicine (Baltimore) 2020 Mar;99(13):e19660

Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.

Stereotactic body radiation therapy (SBRT) has emerged as a treatment option for unresectable hepatocellular carcinoma (HCC) patients. However, the treatment outcomes for patients with portal vein tumor thrombosis (PVTT) remain poor. In this study, we evaluate the efficacy of SBRT with and or without sorafenib for advanced HCC with PVTT. Read More

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http://dx.doi.org/10.1097/MD.0000000000019660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220154PMC

Temporal subtraction of low-dose and relatively thick-slice CT images with large deformation diffeomorphic metric mapping and adaptive voxel matching for detection of bone metastases: A STARD-compliant article.

Medicine (Baltimore) 2020 Mar;99(12):e19538

Department of Diagnostic Radiology and Nuclear Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu City, Shizuoka, Japan.

To evaluate the improvement of radiologist performance in detecting bone metastases at follow up low-dose computed tomography (CT) by using a temporal subtraction (TS) technique based on an advanced nonrigid image registration algorithm.Twelve patients with bone metastases (males, 5; females, 7; mean age, 64.8 ± 7. Read More

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http://dx.doi.org/10.1097/MD.0000000000019538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220493PMC

Primary testicular diffuse large B-cell lymphoma: Case series.

Medicine (Baltimore) 2020 Mar;99(12):e19463

Department of Pathology.

Rationale: Primary testicular lymphoma (PTL) is a rare type of extranodal non-Hodgkin's lymphoma (NHL). Although data of PTL in patients with diffuse large B-cell lymphoma (DLBCL) are accumulating, there are still patients respond poorly to prognosis.

Patient Concerns: All patients had disease of the DLBCL subtype and those patients had primary involvement of the testis. Read More

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http://dx.doi.org/10.1097/MD.0000000000019463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220436PMC

Development and validation of a driving simulator for evaluating the residual effects of drugs on driving performance - sensitivity analysis using zopiclone as a positive control: Study Protocol Clinical Trial (SPIRIT Compliant).

Medicine (Baltimore) 2020 Mar;99(12):e19395

Department of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya, Aichi.

Introduction: Drugs acting on the central nervous system (CNS), especially hypnotics, can impair driving. The US Food and Drug Administration started requiring pharmaceutical companies to evaluate the residual influence of CNS agents on driving performance to review their recommended doses. Although it is important for physicians to discuss automobile driving while on medication with patients to promote traffic safety, the package inserts of most CNS agents in Japan uniformly prohibit patients from driving. Read More

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http://dx.doi.org/10.1097/MD.0000000000019395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220102PMC

History of diabetes may delay antibiotic administration in patients with severe sepsis presenting to emergency departments.

Medicine (Baltimore) 2020 Mar;99(11):e19446

Division of Acute and Critical Care Medicine, Hokkaido University Graduate School of Medicine.

Clinical manifestations of sepsis differ between patients with and without diabetes mellitus (DM), and these differences could influence the clinical behaviors of medical staff. Therefore, we aimed to investigate whether pre-existing DM was associated with the time to antibiotics or sepsis care protocols.This was a retrospective cohort study. Read More

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http://dx.doi.org/10.1097/MD.0000000000019446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220469PMC

Apatinib combined with chemotherapy or concurrent chemo-brachytherapy in patients with recurrent or advanced cervical cancer: A phase 2, randomized controlled, prospective study.

Medicine (Baltimore) 2020 Mar;99(11):e19372

Department of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University, Qingdao.

Objective: Apatinib mesylate is a novel vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor, which has exhibited good safety and efficacy in several types of solid tumors. The present study aimed to assess the clinical efficacy and safety of apatinib combined with chemotherapy and concurrent chemo-brachytherapy (CCBT) in patients with recurrent and advanced cervical cancer.

Methods: A total of 52 patients with first diagnosed recurrent or untreated International Federation of Gynecology and Obstetrics stage IVB cervical cancer admitted at Shandong Cancer Hospital and Institute between July 2016 and May 2018 were analyzed in the current randomized controlled trial. Read More

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http://dx.doi.org/10.1097/MD.0000000000019372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220314PMC

What is the relevance of an ambulatory quick diagnosis unit or inpatient admission for the diagnosis of pancreatic cancer? A retrospective study of 1004 patients.

Medicine (Baltimore) 2020 Mar;99(11):e19009

Department of Internal Medicine, Hospital Clínic, University of Barcelona.

Quick diagnosis units (QDU) have become an alternative hospital-based ambulatory medicine strategy to inpatient hospitalization for potentially serious illnesses in Spain. Whether diagnosis of pancreatic cancer is better accomplished by an ambulatory or inpatient approach is unknown. The main objective of this retrospective study was to examine and compare the diagnostic effectiveness of a QDU or inpatient setting in patients with pancreatic cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000019009DOI Listing

Repair versus nonrepair of medial meniscus posterior root tear: A systematic review of patients' selection criteria, including clinical and radiographic outcomes.

Medicine (Baltimore) 2020 Mar;99(10):e19499

Department of Orthopaedic Surgery, Hallym University Dongtan Sacred Heart Hospital, Gyeonggi-do.

Background: The general consensus regarding a rational choice among various treatment strategies for medial meniscus posterior root tears (MMPRTs) has yet to be clearly established. The purpose of this systematic review was to analyze patient selection criteria based on index arthrosis, as well as clinical and radiological outcomes after repair or nonrepair treatment in patients with MMPRTs.

Methods: A systematic electronic search was performed with established medical databases. Read More

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http://dx.doi.org/10.1097/MD.0000000000019499DOI Listing
March 2020
5.723 Impact Factor

Development and validation of a radiomics model based on T2WI images for preoperative prediction of microsatellite instability status in rectal cancer: Study Protocol Clinical Trial (SPIRIT Compliant).

Medicine (Baltimore) 2020 Mar;99(10):e19428

Department of Radiology, West China Hospital, Sichuan University, Chengdu.

Introduction: Globally, colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. Rectal cancer (RC) accounts for about 28% of all newly diagnosed CRC cases. The treatment of choice for locally advanced RC is a combination of surgical resection and chemotherapy and/or radiotherapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000019428DOI Listing
March 2020
5.723 Impact Factor

Prognostic significance of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in patients with metastatic gastric cancer.

Medicine (Baltimore) 2020 Mar;99(10):e19405

Department of Oncology, Affiliated Hospital of Qingdao University, Qingdao Shandong, China.

Advanced gastric cancer has a poor prognosis because of advanced gastric cancer is prone to metastasis. It is urgent for us to find an indicator to predict the prognosis of gastric cancer in a timely fashion. Research has revealed that inflammation has an important role in predicting survival in some cancers. Read More

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http://dx.doi.org/10.1097/MD.0000000000019405DOI Listing

The therapeutic efficacy of 177Lu-DOTATATE/DOTATOC in advanced neuroendocrine tumors: A meta-analysis.

Medicine (Baltimore) 2020 Mar;99(10):e19304

Department of PET/CT, First Affiliated Hospital, Harbin Medical University, Harbin, China.

Background: Somatostatin analog therapies showed great potential for patients suffering advanced neuroendocrine tumors (NETs). This study was aimed to evaluate the therapeutic efficacy of Lu-DOTATATE/DOTATOC (Lu-octreotate/octreotide) peptide receptor radionuclide therapy (PRRT) in advanced or inoperable NETs patients.

Methods: Pubmed, Web of Science, Embase and Cochrane Library were searched from 1950 to April 2019. Read More

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http://dx.doi.org/10.1097/MD.0000000000019304DOI Listing

Willingness to pay for a quality-adjusted life year among advanced non-small cell lung cancer patients in Viet Nam, 2018.

Medicine (Baltimore) 2020 Feb;99(9):e19379

Viet Nam Health Economics Association, Hanoi, Viet Nam.

To examine the willingness to pay (WTP) for a quality-adjusted life year (QALY) gained among advanced non-small cell lung cancer (NSCLC) patients in Viet Nam and to analyze the factors affecting an individual's WTP.A cross-sectional, contingent valuation study was conducted among 400 NSCLC patients across 6 national hospitals in Viet Nam. Self-reported information was recorded from patients regarding their socio-demographic status, EQ-5D (EuroQol-5 dimensions) utility, EQ-5D vas, and WTP for 1 QALY gained. Read More

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http://dx.doi.org/10.1097/MD.0000000000019379DOI Listing
February 2020

The impact of pain and opioids use on survival in cancer patients: Results from a population-based cohort study and a meta-analysis.

Medicine (Baltimore) 2020 Feb;99(9):e19306

Department of Anesthesiology, Ningbo First Hospital, Ningbo, Zhejiang.

The study aimed to explore whether cancer-related pain and opioids use are associated with the survival of cancer patients, and perform a cohort study and a meta-analysis to quantify the magnitude of any association.A retrospective cohort study was performed to analyze the impact of pain level, and opioids use on cancer-specific survival (CSS) in advanced cancer patients. Patients and relevant medical records were selected from the registry of the Radiation and chemotherapy division of Ningbo First Hospital between June 2013 and October 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000019306DOI Listing
February 2020

Preoperative imatinib treatment in patients with locally advanced and metastatic/recurrent gastrointestinal stromal tumors: A single-center analysis.

Medicine (Baltimore) 2020 Feb;99(9):e19275

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

The advent of imatinib mesylate (IM) has dramatically revolutionized the prognosis of advanced and metastatic/recurrent gastrointestinal stromal tumors (GISTs). The objective of this retrospective study is to investigate the safety and efficacy of combination of surgery following IM treatment in the management of advanced and metastatic/recurrent GISTs. We further explore the long-term clinical outcomes in these who underwent therapy of preoperative IM. Read More

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http://dx.doi.org/10.1097/MD.0000000000019275DOI Listing
February 2020

Detection of extremity chronic traumatic osteomyelitis by machine learning based on computed-tomography images: A retrospective study.

Medicine (Baltimore) 2020 Feb;99(9):e19239

College of Information Science & Electronic Engineering, Key Lab. of Advanced Micro/Nano Electronics Devices & Smart Systems of Zhejiang, Zhejiang University.

Despite the availability of a series of tests, detection of chronic traumatic osteomyelitis is still exhausting in clinical practice. We hypothesized that machine learning based on computed-tomography (CT) images would provide better diagnostic performance for extremity traumatic chronic osteomyelitis than the serological biomarker alone. A retrospective study was carried out to collect medical data from patients with extremity traumatic osteomyelitis according to the criteria of musculoskeletal infection society. Read More

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http://dx.doi.org/10.1097/MD.0000000000019239DOI Listing
February 2020

The efficacy of manual therapy (Chuna) for chronic obstructive pulmonary disease: Protocol for a systematic review.

Medicine (Baltimore) 2020 Feb;99(9):e18832

Department of Clinical Korean Medicine.

Background: Chronic obstructive pulmonary disease (COPD) is a challenging disease whose prevalence has increased over the last decades. Non-pharmacological therapies such as pulmonary rehabilitation occupy a core position in patient management. Among these therapies, manual therapy reduces symptoms and increases exercise capacity targeting musculoskeletal problems. Read More

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http://dx.doi.org/10.1097/MD.0000000000018832DOI Listing
February 2020

Trends in late and advanced HIV diagnoses among migrants in Australia; implications for progress on Fast-Track targets: A retrospective observational study.

Medicine (Baltimore) 2020 Feb;99(8):e19289

Public Health, Burnet Institute.

Achieving the Joint United Nations Program on human immunodeficiency virus (HIV)/AIDS Fast-Track targets requires additional strategies for mobile populations. We examined trends and socio-demographics of migrants (overseas-born) and Australian-born individuals presenting with late and advanced HIV diagnoses between 2008 and 2017 to help inform public health approaches for HIV testing coverage and linkage to care and treatment.We conducted a retrospective population-level observational study of individuals diagnosed with HIV in Australia and reported to the National HIV Registry. Read More

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http://dx.doi.org/10.1097/MD.0000000000019289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034696PMC
February 2020
5.723 Impact Factor

Retrospective imaging studies of gastric cancer: Study protocol clinical trial (SPIRIT Compliant).

Medicine (Baltimore) 2020 Feb;99(8):e19157

Department of Radiology, West China Hospital.

Introduction: Peritoneal metastasis (PM) is a frequent condition in patients presenting with gastric cancer, especially in younger patients with advanced tumor stages. Computer tomography (CT) is the most common noninvasive modality for preoperative staging in gastric cancer. However, the challenges of limited CT soft tissue contrast result in poor CT depiction of small peritoneal tumors. Read More

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http://dx.doi.org/10.1097/MD.0000000000019157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034669PMC
February 2020
5.723 Impact Factor

Visual function evaluation for low vision patients with advanced glaucoma.

Medicine (Baltimore) 2020 Feb;99(7):e19149

Department of Ophthalmology, Seoul St. Mary's Hospital.

This study aimed to compare various visual function parameters for evaluating the quality of life (QOL) of patients with advanced glaucoma with low vision.In total, 44 eyes of advanced glaucoma patients with low vision were included in this cross-sectional study. A moving pattern edge band program was used to assess edge detection ability and the low vision quality-of-life (LVQOL) questionnaire was used for evaluating QOL scores of subjects. Read More

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http://dx.doi.org/10.1097/MD.0000000000019149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035097PMC
February 2020

Ecological study on needs and cost of treatment for dental caries in schoolchildren aged 6, 12, and 15 years: Data from a national survey in Mexico.

Medicine (Baltimore) 2020 Feb;99(7):e19092

Richard M. Fairbanks School of Public Health, Indiana University/Purdue University, Indianapolis.

To determine the treatment needs and the care index for dental caries in the primary dentition and permanent dentition of schoolchildren and to quantify the cost of care that would represent the treatment of dental caries in Mexico.A secondary analysis of data from the First National Caries Survey was conducted, which was a cross-sectional study conducted in the 32 states of Mexico. Based on dmft (average number of decayed, extracted, and filled teeth in the primary dentition) and DMFT (average number of decayed, extracted, and filled teeth in permanent dentition) information, a treatment needs index (TNI) and a caries care index (CI) were calculated. Read More

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http://dx.doi.org/10.1097/MD.0000000000019092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035119PMC
February 2020

Skeletal muscle mass predicts the outcome of nivolumab treatment for non-small cell lung cancer.

Medicine (Baltimore) 2020 Feb;99(7):e19059

Department of Innovative Cancer Immunotherapy, Gunma University Graduate School of Medicine.

Nivolumab, a monoclonal antibody targeting programmed cell death-1, significantly prolongs survival for patients with advanced non-small-cell lung cancer (NSCLC). However, little is known about the value of predictive biomarkers. Hence, we investigated the impact of skeletal muscle (SM) mass loss on clinical outcomes in NSCLC patients undergoing nivolumab treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000019059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035054PMC
February 2020