Search our Database of Scientific Publications and Authors

I’m looking for a

    375 results match your criteria Advanced Studies in Medicine [Journal]

    1 OF 8

    The prognostic value and potential drug target of phosphatase and tensin homolog in breast cancer patients: A meta-analysis.
    Medicine (Baltimore) 2017 Sep;96(36):e8000
    Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
    Background: The prognostic significance of phosphatase and tensin homolog (PTEN) in patients with breast cancer (BC) remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic value in patients with breast cancer.

    Methods: PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure (CNKI) were systematically searched up to December 2016. Read More

    Clinical features of idiopathic restrictive cardiomyopathy: A retrospective multicenter cohort study over 2 decades.
    Medicine (Baltimore) 2017 Sep;96(36):e7886
    aDepartment of Cardiology, Asan Medical Center, University of Ulsan College of Medicine bDepartment of Internal Medicine, Seoul National University Hospital cDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul dDepartment of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju eDepartment of Internal Medicine, Wonju College of Medicine,Yonsei University, Wonju fDepartment of Internal Medicine, Kangbuk Samsung Hospital, Seoul gDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University school of Medicine, Bundang hDepartment of Cardiology, Sejong General Hospital iDepartment of Cardiovascular Medicine, Gachon University Gil Medical Center, Incheon jDepartment of Internal Medicine, Chungbuk National University School of Medicine, Cheongju, Korea.
    Idiopathic restrictive cardiomyopathy (RCMP) has not been fully understood because this disease is difficult to diagnose. The present study aimed to assess the clinical profile and outcome of idiopathic RCMP from a multicenter cohort.This investigation is a retrospective study of consecutive patients with idiopathic RCMP at 10 centers in Korea between 1990 and 2010. Read More

    Comparative analysis of diagnostic colonoscopy in symptomatic young adults from South Korea and the United States.
    Medicine (Baltimore) 2017 Sep;96(35):e7504
    aDepartment of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine bDepartment of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea cDigestive Disease Institute, Virginia Mason Medical Center, Seattle, WA.
    To date, not much is known about ethnic differences in the prevalence of colorectal neoplasia in symptomatic young patients with lower gastrointestinal symptoms. This study sought to compare diagnostic colonoscopic findings in symptomatic young patients from South Korea and the United States. Results from the first diagnostic colonoscopies in symptomatic 18- to 49-year-old patients were compared between the United States and Korean cohorts. Read More

    Trend analysis of end-of-life care between hospice and nonhospice groups of cancer patients in Taiwan for 2002-11.
    Medicine (Baltimore) 2017 Aug;96(34):e7825
    aDepartment of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi bDivision of Hematology and Oncology, Tainan Municipal Hospital, Tainan cDepartment of Family Medicine, Tainan Municipal Hospital, Tainan, Taiwan.
    The aim of the study is to examine the effect of hospice care on quality of end-of-life (EOL) care for patients with advanced cancer in Taiwan between 2002 and 2011.It is a population-based longitudinal study following National Health Insurance medical care claims of hospice and nonhospice patients with advanced cancer in their last month of life.Utilization of hospice service doubled from 10. Read More

    Effective apatinib treatment of pleomorphic liposarcoma: A case report.
    Medicine (Baltimore) 2017 Aug;96(33):e7771
    Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
    Rationale: Pleomorphic liposarcoma (PLS) is a rare and aggressive malignant tumor, and both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease.

    Patient Concerns: We presented an 81-year-old Chinese woman with advanced PLS who received apatinib after failure chemotherapy.

    Diagnoses: The patient was diagnosed as having PLS by biopsy. Read More

    Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma.
    Medicine (Baltimore) 2017 Aug;96(32):e7764
    aTianjin Key Laboratory of Artificial Cell, Tianjin Institute of Hepatobiliary Disease, Artificial Cell Engineering Technology Research Center of Public Health Ministry bDepartment of General Surgery, Third Central Hospital of Tianjin, Tianjin, China.
    The aim of the study was to explore the clinical significance of let-7 expression in hepatocellular carcinoma (HCC).A PCR array was conducted to screen for let-7 expression in early-stage HCC. Next, the deregulation of let-7 was confirmed by quantitative real-time RT-PCR (qRT-PCR) in another set of liver tissues, including normal control (NC), chronic hepatitis (CH), liver cirrhosis (LC), HCC, and adjacent nontumor (NT) tissues. Read More

    Effects of calcium on the incidence of recurrent colorectal adenomas: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials.
    Medicine (Baltimore) 2017 Aug;96(32):e7661
    aSchool of Pharmacy/School of Postgraduate Studies, International Medical University, Kuala Lumpur bDepartment of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia cMalaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, Malaysia dClinical School, Department of Surgery, International Medical University, Seremban, Negeri Sembilan, Malaysia eCenter of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, Thailand fSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia gCenter of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok hUnit of Excellence on Herbal Medicine, School of Pharmaceutical Sciences, University of Phayao iDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand jSchool of Pharmacy, University of Wisconsin, Madison, USA kAsian Centre for Evidence Synthesis in Population, Implementation and Clinical Outcomes (PICO), Health and Well-being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
    Background: Protective effects of calcium supplementation against colorectal adenomas have been documented in systematic reviews; however, the results have not been conclusive. Our objective was to update and systematically evaluate the evidence for calcium supplementation taking into consideration the risks of systematic and random error and to GRADE the evidence.

    Methods: The study comprised a systematic review with meta-analysis and trial sequential analysis (TSA) of randomized controlled trials (RCTs). Read More

    Clinicopathological features, surgical treatments, and survival outcomes of patients with small bowel adenocarcinoma.
    Medicine (Baltimore) 2017 Aug;96(31):e7713
    aDepartment of Pancreatic and Gastric Surgery bState Key Laboratory of Molecular Oncology cDepartment of Clinical Laboratory, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China dDepartment of Biotherapy, Beijing Hospital, National Center of Gerontology, Beijing, China.
    To date, because of their rarity, the clinicopathological features and surgical outcomes of small bowel adenocarcinomas (SBAs) have been insufficiently explored. We evaluated the clinicopathological features and long-term outcomes of patients who underwent surgery for SBA.This retrospective study (from 1999 to 2016) examined patients with SBA treated surgically at the China National Cancer Center/Cancer Hospital. Read More

    The impact of host's genetic susceptibility on Helicobacter pylori infection in children.
    Medicine (Baltimore) 2017 Jul;96(30):e7612
    aDepartment of Pediatrics, University of Medicine and Pharmacy Tîrgu Mureş bDepartment of Epidemiology, University of Medicine and Pharmacy Tîrgu Mureş cGenetics Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine and Pharmacy Tîrgu Mureş, Romania.
    The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. Read More

    S-1 monotherapy versus S-1 combination therapy in gemcitabine-refractory advanced pancreatic cancer: A meta-analysis (PRISMA) of randomized control trials.
    Medicine (Baltimore) 2017 Jul;96(30):e7611
    aDepartment of Neurosurgery, the First Hospital of Jilin University bClinical College, Jilin University, Changchun, China cDepartment of the Radiotherapy, Hebei University Affiliated Hospital, Baoding dPublic Health College, Jilin University eBasic Medical College, Qiqihar Medical University, Qiqihar fRadiology Department, Jixi Mining General Hospital, Jixi gHepatopancreatobiliary Medicine Department, the First Hospital of Jilin University, Changchun, China.
    Background: Pancreatic cancer (PC) is one of the most lethal digestive system tumors. Most new cases are diagnosed based on metastasis or local aggression and are known as "advanced PC." Recently, studies investigating S-1 have indicated that it has a better clinical curative effect on PC. Read More

    Community burden of undiagnosed HIV infection among adolescents in Zimbabwe following primary healthcare-based provider-initiated HIV testing and counselling: A cross-sectional survey.
    PLoS Med 2017 Jul 25;14(7):e1002360. Epub 2017 Jul 25.
    Biomedical Research and Training Institute, Harare, Zimbabwe.
    Background: Children living with HIV who are not diagnosed in infancy often remain undiagnosed until they present with advanced disease. Provider-initiated testing and counselling (PITC) in health facilities is recommended for high-HIV-prevalence settings, but it is unclear whether this approach is sufficient to achieve universal coverage of HIV testing. We aimed to investigate the change in community burden of undiagnosed HIV infection among older children and adolescents following implementation of PITC in Harare, Zimbabwe. Read More

    Increased nuchal translucency in fetuses with a normal karyotype-diagnosis and management: An observational study.
    Medicine (Baltimore) 2017 Jul;96(29):e7521
    aDepartment of Mother and Child Medicine, University of Medicine and Pharmacy Gr. T. Popa Iasi bHospital of Obstetrics and Gynecology Elena Doamna-Iasi cHuman Genetics Department, University of Medicine and Pharmacy Gr. T. Popa Iasi dUniversity of Medicine and Pharmacy Carol Davila-Bucharest, Romania.
    The use of nuchal translucency (NT) in 1992 by Nicolaides et al was a major breakthrough in screening for chromosomal aneuploidies at the end of the first trimester. However, pathological conditions other than chromosomal aneuploidies are also associated with increased NT, which can also be detected in normal fetuses. This study sought to evaluate the causes of this ultrasound sign in a group of patients from Iasi, Romania. Read More

    Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study.
    BMC Med 2017 Jul 13;15(1):115. Epub 2017 Jul 13.
    Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom.
    Background: The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of and death from prostate cancer in 141,896 men in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

    Methods: Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Read More

    Multiple pedicled flaps cover for large defects following resection of malignant tumors with partition concept.
    Medicine (Baltimore) 2017 Jul;96(27):e7455
    Department of Plastic Surgery, Sun Yat-sen Memorial Hosptial, Sun Yat-sen University, Guangdong Province, China.
    Large defects after skin malignant tumors resection were difficult to repair. We introduced a partition concept, in which the large defects were divided into several subunits, and each subunit was repaired by a certain pedicled flap to achieve a complete coverage.Between May 2012 and Oct 2016, 8 patients with skin malignant tumors underwent radical resection. Read More

    Overall evaluation of the clinical value of prenatal screening for fetal-free DNA in maternal blood.
    Medicine (Baltimore) 2017 Jul;96(27):e7114
    Changzhou Woman and Children Health Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu, China.
    Objective: To explore the clinical value of prenatal screening for fetal-free DNA in maternal blood.

    Methods: A total of 10,275 maternal blood samples were collected from October 2012 to May 2016 at the prenatal diagnosis center of Changzhou Woman and Children Health Hospital.

    Results: Among 10,275 pregnant women accepted noninvasive prenatal testing (NIPT), 9 cases could not get the results after collected the blood second times. Read More

    Multimorbidity and polypharmacy in diabetic patients with NAFLD: Implications for disease severity and management.
    Medicine (Baltimore) 2017 Jun;96(26):e6761
    aDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital bCentre for Liver Disease Research, Translational Research Institute, School of Medicine, The University of Queensland cSchool of Medicine, The University of Queensland dPharmacy Department, Princess Alexandra Hospital eInala Primary Care fPathology Queensland gDepartment of Radiology, Princess Alexandra Hospital hQIMR Berghofer Medical Research Institute iDepartment of Endocrinology, Princess Alexandra Hospital, Brisbane, Australia.
    An observational study describing the number and type of chronic conditions and medications taken by diabetic patients with NAFLD and identifying characteristics that may impact liver disease severity or clinical management.Adults with type 2 diabetes have a high prevalence of nonalcoholic fatty liver disease (NAFLD) and increased risk of developing advanced liver disease. Appropriate management should consider the characteristics of the diabetic NAFLD population, as comorbid conditions and medications may increase the complexity of treatment strategies. Read More

    Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer.
    BMC Med 2017 Jun 26;15(1):118. Epub 2017 Jun 26.
    MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
    Background: Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable investment in molecular risk stratification has sought to overcome the performance ceiling encountered by methods restricted to traditional clinical parameters. However, replication of results has proven challenging, and intratumoural heterogeneity (ITH) may confound attempts at tissue-based stratification. Read More

    Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer.
    BMC Med 2017 Jun 23;15(1):116. Epub 2017 Jun 23.
    Department of Gynecologic Oncology, Cancer Research Center Groningen, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.
    Background: Despite an early response to platinum-based chemotherapy in advanced stage high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug-resistant disease. Aberrant epigenetic alterations like DNA methylation are common in HGSOC. Differences in DNA methylation are associated with chemoresponse in these patients. Read More

    Prognostic impact of Ki-67 in patients with gastric cancer-the importance of depth of invasion and histologic differentiation.
    Medicine (Baltimore) 2017 Jun;96(25):e7181
    aDepartment of Pathology bDepartment of Internal Medicine cDepartment of Surgery, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
    Ki-67 protein is a cellular marker for proliferation. The role of Ki-67 as a prognostic biomarker has not been established in gastric cancer. The present study was performed to investigate the significance of Ki-67 expression as a biomarker in early gastric cancer (EGC). Read More

    Clinical significance of plasma D-dimer in ovarian cancer: A meta-analysis.
    Medicine (Baltimore) 2017 Jun;96(25):e7062
    aNantong Maternity and Child Health Care Hospital, Nantong bNanjing Maternity and Child Health Medical Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing cDepartment of Obstetrics and Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.
    Background: D-dimer has been widely used for the diagnosis and prognosis of ovarian cancer, but there is still controversy on its prediction value of ovarian cancer.

    Objectives: To explore the clinical significance of plasma D-dimer level on ovarian cancer systematically.

    Methods: Using PubMed, Cochrane Library, and Web of Science libraries, all the relevant studies for the diagnostic and prognostic value of plasma D-dimer for ovarian cancer and the relationship between elevated D-dimer level and venous thromboembolism (VTE) risk of ovarian cancer were searched till May 30, 2016. Read More

    Validity of a minimally invasive autopsy tool for cause of death determination in pediatric deaths in Mozambique: An observational study.
    PLoS Med 2017 Jun 20;14(6):e1002317. Epub 2017 Jun 20.
    ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain.
    Background: In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually in low- and middle-income countries remains poor, partly because of the inadequacy and reduced precision of the methods currently utilized in these settings to investigate causes of death (CoDs). The study objective was to validate the use of a minimally invasive autopsy (MIA) approach as an adequate and more acceptable substitute for the complete diagnostic autopsy (CDA) for pediatric CoD investigation in a poor setting. Read More

    Validity of a minimally invasive autopsy for cause of death determination in stillborn babies and neonates in Mozambique: An observational study.
    PLoS Med 2017 Jun 20;14(6):e1002318. Epub 2017 Jun 20.
    ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain.
    Background: Over 5 million stillbirths and neonatal deaths occur annually. Limited and imprecise information on the cause of these deaths hampers progress in achieving global health targets. Complete diagnostic autopsies (CDAs)-the gold standard for cause of death determination-are difficult to perform in most high-burden settings. Read More

    Lymph node metastasis characteristics of papillary thyroid carcinoma located in the isthmus: A single-center analysis.
    Medicine (Baltimore) 2017 Jun;96(24):e7143
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China.
    The frequency and pattern of lymph node metastasis and the extent of dissection for isthmic papillary thyroid carcinoma (PTC) remain unclear, and the aim of this present study was to evaluate these characteristics and to attempt to detect the best surgical protocol for isthmic PTCs. A total of 3185 consecutive patients with PTCs were reviewed. Of these patients, 47 with a single isthmic PTC were enrolled in our study, and matched 47 patients with a single PTC located in the unilateral lobe were randomly selected and added for comparison of their baseline tumor characteristics and lymph node metastasis characteristics. Read More

    Effects of branched-chain amino acids (BCAAs) on the progression of advanced liver disease: A Korean nationwide, multicenter, retrospective, observational, cohort study.
    Medicine (Baltimore) 2017 Jun;96(24):e6580
    aDepartment of Internal Medicine, College of Medicine, Yeungnam University bDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu cDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea dDepartment of Internal Medicine, College of Medicine, Soonchunhyang University eDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul fDepartment of Internal Medicine, Ilsan Paik Hospital, College of Medicine, Inje University College of Medicine, Goyang gDepartment of Internal Medicine, College of Medicine, Hallym University, Chuncheon hDepartment of Internal Medicine, School of Medicine, Chonbuk National University, Chungju iDepartment of Internal Medicine, School of Medicine, Keimyung University, Daegu jDepartment of Internal Medicine, College of Medicine, Dongguk University, Gyeongju kDepartment of Internal Medicine, School of Medicine, Pusan National University, Pusan lMedical Research Collabration Center in KNUH and School of Medicine, Kyungpook National University, Daegu, Korea.
    Evidence of the potential benefits of long-term oral branched-chain amino acid (BCAA) supplementation in reducing the severity of liver disease is limited.Patients who were diagnosed with liver cirrhosis with a Child-Pugh (CP) score of 8-10 were included. The BCAA group consumed BCAAs daily for at least 6 months, and the control group consumed a diet without BCAA. Read More

    Clinicopathological and prognostic significance of homeobox transcript antisense RNA expression in various cancers: A meta-analysis.
    Medicine (Baltimore) 2017 Jun;96(23):e7084
    aDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, Beijing bSchool of Life Science, University of Science and Technology of China, Hefei cDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
    Background: Increased expression of the homeobox (HOX) transcript antisense RNA (HOTAIR) has been reported in multiple types of malignancies and enhances the proliferation and migration of cancer cells. However, the association between HOTAIR expression and tumor progression and prognosis remains controversial. We performed a meta-analysis to clarify the association between the expression of HOTAIR and the clinicopathological features and prognosis in different cancers. Read More

    Surgery of the primary tumor improves survival in women with stage IV breast cancer in Southwest China: A retrospective analysis.
    Medicine (Baltimore) 2017 Jun;96(22):e7048
    aCancer Center bLaboratory of Molecular Diagnosis of Cancer, State Key Laboratory of Biotherapy, National Collaborative Innovation Center for Biotherapy cState Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu dDepartments of Anesthesiology, Mianyang Central Hospital, Mianyang, Sichuan, China.
    The International Consensus Guidelines for advanced breast cancer (ABC) considers that the surgery of the primary tumor for stage IV breast cancer patients does not usually improve the survival. However, studies have showed that resection of the primary tumor may benefit these patients. The correlation between surgery and survival remains unclear. Read More

    Identification of groups with poor cost-effectiveness of peginterferon plus ribavirin for naïve hepatitis C patients with a real-world cohort and database.
    Medicine (Baltimore) 2017 Jun;96(22):e6984
    aHepatobiliary Division, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital bDepartment of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital cFaculty of Internal Medicine, College of Medicine, Kaohsiung Medical University dInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
    Background: For decades, peginterferon and ribavirin (PegIFN/RBV) have been the standard-of-care for chronic hepatitis C virus (CHC) infection. However, the actual cost-effectiveness of this therapy remains unclear. We purposed to explore the real-world cost effectiveness for subgroups of treatment-naïve CHC patients with PegIFN/RBV therapy in a large real-world cohort using a whole population database. Read More

    Prognostic significance of urothelial carcinoma with divergent differentiation in upper urinary tract after radical nephroureterectomy without metastatic diseases: A retrospective cohort study.
    Medicine (Baltimore) 2017 May;96(21):e6945
    aDepartment of Urology bTianjin Key Laboratory of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University cCollege of Management and Economics, Tianjin University, Tianjin, China.
    To evaluate the impact of urothelial carcinoma with divergent differentiation (UCDD) on the prognosis of patients for primary upper urinary tract urothelial carcinoma (UTUC) with pN0/x status treated with radical nephroureterectomy (RNU) and to evaluate the prognostic value of UCDD in different tumor locations (renal pelvis and ureter).Data from a total of 346 patients with UTUC who received RNU between January 2012 and March 2016 in the institution were retrospectively analyzed. Clinicopathological features and prognostic factors age, sex, complaint, height, weight, blood pressure, tumor grade, stage, smoking status, history of adjuvant chemotherapy, tumor location, history of bladder cancer, tumor necrosis, degree of hydronephrosis, tumor size, tumor focality, and preoperative anemia were compared between patients with pure UTUC and patients with UCDD. Read More

    Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients.
    Medicine (Baltimore) 2017 May;96(20):e6931
    aSharett Institute of Oncology bLeslie and Michael Gaffin Center for Oncology, Departments of Oncology and Neurology, Hebrew University-Hadassah Medical Center cDepartment of Pediatrics, Hadassah Medical Center, Division of Pediatric Hematology and Oncology dLautenberg Center for Immunology, IMRIC, The Hebrew University-Hadassah Medical School eDepartment of Pathology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
    Molecular portraits of numerous tumors have flooded oncologists with vast amounts of data. In parallel, effective inhibitors of central pathways have shown great clinical benefit. Together, this promises potential clinical benefits to otherwise end-stage cancer patients. Read More

    Prognostic impact of C-reactive protein/albumin ratio on the overall survival of patients with advanced nonsmall cell lung cancers receiving palliative chemotherapy.
    Medicine (Baltimore) 2017 May;96(19):e6848
    aDepartment of Pathology bDepartment of Hematology-Oncology, Ajou University School of Medicine, Suwon, Republic of Korea.
    Recent studies have indicated that the C-reactive protein (CRP)/albumin (CRP/Alb) ratio is associated with clinical outcomes in patients with various carcinomas. However, no studies have explored the association between the ratio of CRP/Alb and clinical outcome of inoperable patients with nonsmall cell lung cancers (NSCLCs). We examined the prognostic impact of CRP/Alb ratio on 165 stage IV NSCLC receiving palliative chemotherapy. Read More

    Alteration of serum high-mobility group protein 1 (HMGB1) levels in children with enterovirus 71-induced hand, foot, and mouth disease.
    Medicine (Baltimore) 2017 Apr;96(17):e6764
    Department of Childhood Infectious Diseases, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Hand, foot, and mouth disease (HFMD) is a common pediatric disease caused by enterovirus infection. It typically presents as a fever along with flat, discolored spots and bumps on the hands, feet, and mouth. Compared with other viruses, enterovirus 71 (EV71)-induced HFMD is more prone to cause severe complications in children, such as brainstem encephalitis, cardiopulmonary disorders, and even death. Read More

    Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients.
    Medicine (Baltimore) 2017 Apr;96(17):e6694
    Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Hyperfibrinogenemia has been reported to be a predictor of poor prognosis in cancer patients, and in hepatocellular carcinoma (HCC) patients, survival remains uncertain and unpredictable. The aim of the present study was to evaluate the association between the level of plasma fibrinogen and overall survival in HCC patients.Overall, 308 patients with histologically proven HCC were included in our study. Read More

    Identifying pretreatment baseline factors predictive of distant metastasis in patients with nasopharyngeal carcinoma after radiotherapy.
    Medicine (Baltimore) 2017 Apr;96(17):e6692
    Department of Oncology, Jiangmen Central Hospital, Jiangmen, China.
    This retrospective study was performed to identify pretreatment baseline factors that could predict the development of distant metastasis (DM) in patients with nasopharyngeal carcinoma (NPC).A cohort of 119 NPC patients undergoing radiotherapy (RT) or chemoradiotherapy (CRT) were recruited into the study. Among them, 51 developed DM (DM group) within 3 years after treatment and 68 did not (DM-free group). Read More

    Evaluation of gemcitabine efficacy after the FOLFIRINOX regimen in patients with advanced pancreatic adenocarcinoma.
    Medicine (Baltimore) 2017 Apr;96(16):e6544
    aDepartment of Medical Oncology, Paoli-Calmettes Institute, Marseille, France bDepartment of Medical Oncology, Jewish General Hospital, McGill University, Montréal, QC , Canada cDepartment of Gastroenterology dDepartment of Digestive Surgery, Paoli-Calmettes Institute, Marseille, France.
    To evaluate gemcitabine efficacy in advanced pancreatic cancer patients after the FOLFIRINOX regimen.Patients with locally-advanced or metastatic pancreatic adenocarcinoma from French and Canadian centers, who were treated with the first-line FOLFIRINOX regimen (FFX L1), followed by gemcitabine monotherapy as a second-line treatment (GEM L2), were retrospectively evaluated. Statistical analyses were performed on the demographic, toxicity, and response rate data. Read More

    Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma.
    Medicine (Baltimore) 2017 Apr;96(15):e6518
    Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
    There is no standard third-line or further systemic treatment for patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma (NPC). Metronomic oral cyclophosphamide provides an acceptable and cheap option for these heavily pretreated patients who had limited choices. We conducted a prospective phase II single-arm open-label study of metronomic oral cyclophosphamide. Read More

    Clinical outcomes of anterior cruciate ligament reconstruction using LARS artificial graft with an at least 7-year follow-up.
    Medicine (Baltimore) 2017 Apr;96(14):e6568
    aDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China bDepartment of Orthopedics, Chengdu Military General Hospital, Chengdu, China.
    The aim of our study was to assess the medium-term clinical outcomes of anterior cruciate ligament (ACL) reconstruction using the Ligament Advanced Reinforcement System (LARS) artificial ligament.A total of 168 patients who underwent arthroscopic ACL reconstruction with the LARS artificial ligament in our department were enrolled in our research. Only 125 met the inclusion/exclusion criteria, and 91 could ultimately be contacted to participate in our research. Read More

    Patient characteristics and perceived health status of individuals with HIV and tuberculosis coinfection in Guangxi, China.
    Medicine (Baltimore) 2017 Apr;96(14):e6475
    aDepartment of Infection, Eighth Affiliated Hospital of Guangxi Medical University, Guigang City People's Hospital, Guigang bDepartment of Infection, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China cSchool of Pharmacy, West Virginia University, Morgantown, WV, USA dGuangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning eGuangxi University of Chinese Medicine, Nanning, Guangxi, China.
    To explore demographics, clinical and medication profiles, patients' social support, and perceived health status in HIV/TB coinfected patients in Guangxi, China.We performed a cross-sectional study in the HIV clinic of the Guigang City People's Hospital (N = 150). Health professionals conducted face-to-face interviews and collected data from patients' electronic medical records regarding patients' demographic, clinical, and medication information, as well as their social support and perceived health status. Read More

    Does the pancreatic volume reduction rate using serial computed tomographic volumetry predict new onset diabetes after pancreaticoduodenectomy?
    Medicine (Baltimore) 2017 Mar;96(13):e6491
    aDepartment of Surgery bDepartment of Radiology cDepartment of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
    Volume reduction of the pancreatic tissues following a pancreatectomy can lead to the deterioration of glucose homeostasis. This is defined as pancreatogenic diabetes mellitus (DM). The objective of this study was to investigate the occurrence of new-onset DM (NODM) and evaluate the risk factors, including the pancreas volume reduction rate in patients undergoing pancreaticoduodenectomy (PD). Read More

    Systematic review and meta-analysis of preoperative chemoradiotherapy with or without oxaliplatin in locally advanced rectal cancer.
    Medicine (Baltimore) 2017 Mar;96(13):e6487
    Department of General Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.
    Background: Preoperative chemoradiotherapy has become the current standard regimen for locally advanced rectal cancer (LARC). However, the additional benefit of oxaliplatin to preoperative chemotherapy was still controversial. On one hand, oxaliplatin may improve the tumor response rate of even prolong the survival time. Read More

    Prognostic implication of hepatoduodenal ligament lymph nodes in gastric cancer.
    Medicine (Baltimore) 2017 Mar;96(13):e6464
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea.
    There has been controversy regarding whether hepatoduodenal lymph node (HDLN) metastasis in gastric cancer is distant or regional metastasis. HDLN positivity was classified as distant metastasis in the 7th American Joint Committee on Cancer (AJCC) classification, but it was reclassified as regional lymph node metastasis in the 8th AJCC classification. The aim of our study is to verify prognostic significance of HDLN metastasis in gastric cancer. Read More

    Varying postresection lactate dehydrogenase with overall survival of early stage pancreatic cancer patients: A retrospective study.
    Medicine (Baltimore) 2017 Mar;96(12):e6399
    aSchool of Public Health, Kunming Medical University, Kunming, Yunnan bDepartment of Biostatistics, School of Public Health, Fudan University cInformation Center, Shanghai Municipal Commission of Health and Family Planning dKey Lab of Health Technology Assessment, Ministry of Health (Fudan University), Shanghai, China.
    Several previously published studies revealed a hazardous role of pretreatment lactate dehydrogenase (LDH) in survival of advanced or metastatic pancreatic cancer (PC) patients. Nevertheless, in early stage PC patients who are eligible for curative resection, the prognostic role of postresection LDH has never been discussed. In this study, we aimed to explore the prognostic significance of varying postresection LDH among early stage PC patients. Read More

    Association between macular degeneration and mild to moderate chronic kidney disease: A nationwide population-based study.
    Medicine (Baltimore) 2017 Mar;96(11):e6405
    aDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung bCollege of Medicine, Chang Gung University, Taoyuan cCommunity Medicine Research Center, Keelung Chang Gung Memorial Hospital dDepartment of General Surgery eDepartment of Ophthalmology, Chang Gung Memorial Hospital, Keelung fDepartment of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan gDepartment of Nephrology, Chang Gung Memorial Hospital, Linkuo, Taiwan.
    Chronic kidney disease (CKD) and macular degeneration (MD) are 2 grave diseases leading to significant disability secondary to renal failure and blindness. The 2 diseases share not only common risk factors but also similar pathogenic mechanisms to renal and retinal injuries. Previous epidemiological studies indicated association between these 2 diseases. Read More

    Evaluation of intrathecal drug delivery system for intractable pain in advanced malignancies: A prospective cohort study.
    Medicine (Baltimore) 2017 Mar;96(11):e6354
    aPain Clinic of Anesthesiology Department, Central Hospital of China Aerospace Corporation (Aerospace Clinical Medical School of Peking University) bDepartment of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing cDepartment of Pain Management, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong Province, China.
    Pain is prevalent in advanced malignancies; however, some patients cannot get adequate pain relief by conservative routes of analgesic administration or experience serious side effects related to high dose of opioids. For those who have exhausted multimodal conservative analgesic, intrathecal drug delivery is an alternative intervention for truly effective pain management. The objective of this study was to evaluate the clinical efficacy and safety of intrathecal drug delivery system (IDDS) for the treatment of intractable pain in advanced cancer patients. Read More

    Single pemetrexed is noninferior to platinum-based pemetrexed doublet as first-line treatment on elderly Chinese patients with advanced nonsquamous nonsmall cell lung cancer.
    Medicine (Baltimore) 2017 Mar;96(11):e6002
    aDepartment of Oncology, Changzhou No. 2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou bDepartment of Oncology, Department of Clinical Epidemiology, Jiangsu Province Geriatric Institute cDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University dDepartment of Oncology, The Second Affiliated Hospital of Nanjing Medical University eDepartment of Oncology, Jiangsu Province Geriatric Institute fCentral Laboratory, Jiangsu Province Geriatric Institute, Nanjing, China.
    Background: To evaluate the clinical efficacy and toxicity of single pemetrexed treatment compared with platinum-based pemetrexed doublet pemetrexed-based as first-line treatment for advanced nonsquamous nonsmall cell lung cancer (NS-NSCLC) in elderly Chinese patients.

    Methods: The study retrospectively reviewed 175 elderly Chinese patients with NS-NSCLC from June 2010 to September 2013: 90 patients received single pemetrexed treatment, 45 received pemetrexed plus oxaliplatin, and 40 received pemetrexed plus carboplatin. Clinical efficacy was assessed using disease control rate (DCR), overall survival (OS), and progression-free survival (PFS). Read More

    Safety and efficacy of semiextended field intensity-modulated radiation therapy and concurrent cisplatin in locally advanced cervical cancer patients: An observational study of 10-year experience.
    Medicine (Baltimore) 2017 Mar;96(10):e6158
    aDepartment of Radiation Oncology, MacKay Memorial Hospital bDepartment of Medicine, MacKay Medical College, Taipei cDepartment of Radiation Oncology, Changhua Christian Hospital, Changhua dDepartment of Medical Research, MacKay Memorial Hospital eMacKay Junior College of Medicine, Nursing and Management fDepartment of Obstetrics and Gynecology gDepartment of Radiology, Mackay Memorial Hospital, Taipei, Taiwan.
    Patients with locally advanced cervical cancer (LACC) are at risk of para-aortic lymph node (PALN) metastasis. Pelvic concurrent chemoradiotherapy, the current standard treatment for LACC, has a PALN failure rate of 9% according to the Radiation Therapy Oncology Group Trial 90-01, suggesting that it may not completely eliminate all microscopic tumors in the PALNs. To minimize the toxicities associated with conventional prophylactic extended-field radiotherapy, our institute use prophylactic semiextended field radiotherapy that includes only the PALNs below the level of the renal vessels. Read More

    Concurrent apatinib and local radiation therapy for advanced gastric cancer: A case report and review of the literature.
    Medicine (Baltimore) 2017 Mar;96(9):e6241
    aDepartment of Radiation Oncology, Hebei General Hospital, Shijiazhuang, China bDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center cDivision of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health at Houston, Houston, TX dDepartment of Gastrointestinal Surgery eDepartment of Pathology, Hebei General Hospital, Shijiazhuang, China.
    Rationale: Apatinib is a novel anti-angiogenic agent targeting vascular endothelial growth factor receptor-2, which is effective in patients with chemotherapy-refractory gastric cancer. There are no reports of concurrent apatinib with local radiation therapy in elderly patients with advanced gastric cancer. PATIENT CONCERNS AND DIAGNOSES:: we present the first published report of a 70-year-old male patient with advanced gastric cancer who received concurrent apatinib and local radiation therapy after failure of oxaliplatin and S-1 chemotherapy. Read More

    Clinicopathological features and surgical options for synchronous colorectal cancer.
    Medicine (Baltimore) 2017 Mar;96(9):e6224
    aDivision of Colon and Rectal Surgery, Department of Surgery bDepartment of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
    This study was conducted to investigate the clinicopathological features of synchronous cancers and treatment options according to their locations.Records of 8368 patients with colorectal cancer treated at our center between July 2003 and December 2010 were analyzed retrospectively. All synchronous colorectal cancer patients who underwent surgical treatment were included. Read More

    Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study.
    Medicine (Baltimore) 2017 Mar;96(9):e6202
    aDepartment of School of Medical and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences bDepartment of Head and Neck Surgery, Shandong Cancer Hospital affiliated to Shandong University, Jinan, China.
    Epidemiological studies suggest that obesity is a risk of thyroid cancer, especially papillary thyroid cancer (PTC). However, the associations of obesity and clinic-pathological features, especially the association of body mass index (BMI) and lymph node metastasis of thyroid cancer are unclear. Seven hundred ninety-six primary patients with PTC were enrolled in this retrospective cohort study. Read More

    The effect of induction chemotherapy in patients with locally advanced nonsmall cell lung cancer who received chemoradiotherapy: A systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Feb;96(8):e6165
    aDepartment of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan bDepartment of Radiation Oncology, Qianfoshan Hospital Affiliated to Shandong University cDepartment of Oncology, Shandong University School of Medicine, Shandong dDivision of Graduated, Weifang Medical College, Shandong, P.R. China.
    Background: The efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) in patients with locally advanced nonsmall cell lung cancer (NSCLC) is unclear, we performed a systematic review and meta-analysis of published papers to quantitatively evaluate the potential benefit of induction chemotherapy.

    Methods: Eligible studies of induction chemotherapy and chemoradiotherapy were retrieved through extensive searches of the PubMed, Science Direct, Embase, and Cochrane library databases from 1994 to 2015. We excluded studies that using non-English. Read More

    Association between beat-to-beat blood pressure variability and vascular elasticity in normal young adults during the cold pressor test.
    Medicine (Baltimore) 2017 Feb;96(8):e6000
    aResearch Center for Biomedical Information Technology, Shenzhen Institute of Advance Technology, Chinese Academic of Science bShenzhen Children Hospital cDepartment of Neurology, Shenzhen Second People's Hospital, Futian District dShenzhen College of Advanced Technology, University of Chinese Academy of Sciences,Shenzhen University Town, Shenzhen, China.
    The beat-to-beat blood pressure (BP) monitoring parameters, such as average beat-to-beat BP, BP variability (BPV), could have an influence on the vascular elasticity. This study hypothesized that the elevated beat-to-beat BPV could evoke the reduction of the vascular elasticity independent of BP levels. We measured the beat-to-beat BP recordings and total arterial compliance (TAC), which was used to assess the vascular elasticity, in 80 young healthy adults during the cold pressor test (CPT). Read More

    1 OF 8