514,919 results match your criteria Advanced Studies in Medicine [Journal]


Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Gastroenterology and Hepatology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: The recommendation in regards to screening for non-alcoholic fatty liver disease (NAFLD) among type 2 diabetes mellitus (T2DM) patients differs in major guidelines.

Aim: To study the prevalence of NALFD and advanced fibrosis among T2DM patients.

Methods: Cross-sectional study of consecutive adult T2DM patients attending the Diabetes Clinic of a university hospital. Read More

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December 2018
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Risk factors for death among patients with Chikungunya virus infection during the outbreak in northeast Brazil, 2016-2017.

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará-UFC. Fortaleza, Ceará, Brazil.

Background: Chikungunya virus (CHIKV) infection is a current public health problem. The aim of this study was to investigate risk factors for death among patients with CHIKV infection during a large epidemic in northeast Brazil.

Methods: This is a cross-sectional study with all registered cases of CHIKV in Ceara, Brazil, during 2016-2017. Read More

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December 2018

Cytological and molecular aspects of the ageing sperm.

Hum Reprod 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Seminology - Sperm Bank 'Loredana Gandini' Department of Experimental Medicine, 'Sapienza' University of Rome, Italy.

Study Question: Is ageing associated with a decline in semen quality and molecular changes to human sperm?

Summary Answer: Semen quality declines with advancing age and characteristic molecular changes take place during the ageing process, including increased sperm DNA damage, altered sperm protamination and altered seminal plasma miRNA profile.

What Is Known Already: During ageing, the reproductive system is exposed to physiological changes and potentially damaging factors that may impair testicular function. Reactive oxygen species (ROS) can induce errors during DNA replication, transcription or post-transcriptional events (fragmentation, chromatin condensation abnormalities and protamine expression defects). Read More

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December 2018

Responses of propagule germination and sexual reproduction of submerged macrophytes exposed to cadmium.

Chemosphere 2018 Dec 8;219:436-443. Epub 2018 Dec 8.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China. Electronic address:

Submerged macrophytes are considered the main primary producers in shallow lakes. Recently, they have experienced a decline due to increasing environmental impacts, e.g. Read More

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December 2018

High-performance carbon/MnO micromotors and their applications for pollutant removal.

Chemosphere 2018 Dec 7;219:427-435. Epub 2018 Dec 7.

Institute of Environmental Engineering, ETH Zurich, Schafmattstrasse 6, 8093, Zurich, Switzerland; Advanced Analytical Technologies Laboratory, EMPA, Überlandstrasse 129, 8600, Dübendorf, Switzerland. Electronic address:

The wide applications of particulate micromotors in practice, especially in the removal of environmental pollutants, have been limited by the low production yields and demand on high concentration of fuel such as HO. Carbon/MnO micromotors were made hydrothermally using different carbon allotropes including graphite, carbon nanotube (CNT), and graphene for treatment of methylene blue and toxic Ag ions. The obtained micromotors showed high speed of self-propulsion. Read More

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December 2018
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Cyclodextrin-enhanced 1,4-dioxane treatment kinetics with TCE and 1,1,1-TCA using aqueous ozone.

Chemosphere 2018 Nov 29;219:335-344. Epub 2018 Nov 29.

Water Science and Management Program, New Mexico State University, MSC 3Q P.O. Box 30003, Las Cruces, NM 88003, USA; Plant & Environmental Science, New Mexico State University, MSC 3Q P.O. Box 30003, Las Cruces, NM 88003, USA. Electronic address:

Enhanced reactivity of aqueous ozone (O) with hydroxypropyl-β-cyclodextrin (HPβCD) and its impact on relative reactivity of O with contaminants were evaluated herein. Oxidation kinetics of 1,4-dioxane, trichloroethylene (TCE), and 1,1,1-trichloroethane (TCA) using O in single and multiple contaminant systems, with and without HPβCD, were quantified. 1,4-Dioxane decay rate constants for O in the presence of HPβCD increased compared to those without HPβCD. Read More

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November 2018

Use of iron ore tailing from tailing dam as catalyst in a fenton-like process for methylene blue oxidation in continuous flow mode.

Chemosphere 2018 Dec 7;219:328-334. Epub 2018 Dec 7.

Reseacher at Federal University of Minas Gerais, Chemistry Department, Av. Pres. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, 31270-901, Brazil. Electronic address:

The global demand for iron ore with high iron contents to supply the steel industry is associated, in most countries, with the generation of tailings from mineral processing. The chemical compositions of iron ore tailings (basically FeO and SiO) make them an excellent candidate as a catalyst for advanced oxidation processes (AOPs), especially the Fenton process and its derivatives. Therefore, this paper aimed to transform iron ore tailings from tailing dams into catalysts able to activate HO for the purpose of treating, in a continuous flow, effluents contaminated with organic dyes, employing methylene blue as a model molecule. Read More

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December 2018
2 Reads

Self-faceting of emulsion droplets as a route to solid icosahedra and other polyhedra.

J Colloid Interface Sci 2018 Dec 2;538:541-545. Epub 2018 Dec 2.

Department of Physics, Bar-Ilan University, Ramat-Gan 5290002, Israel; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel. Electronic address:

Hypothesis: Temperature-controlled self-faceting of liquid droplets has been recently discovered in surfactant-stabilized alkane-in-water emulsions. We hypothesize that similar self-faceting may occur in emulsion droplets of UV-polymerizable linear hydrocarbons. We further hypothesize that the faceted droplet shapes can be fixed by UV-initiated polymerization, thus providing a new route towards the production of solid polyhedra. Read More

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December 2018

Synergy of partial-denitrification and anammox in continuously fed upflow sludge blanket reactor for simultaneous nitrate and ammonia removal at room temperature.

Bioresour Technol 2018 Dec 5;274:386-394. Epub 2018 Dec 5.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, China. Electronic address:

In this study, the synergy of high nitrite (NO-N) accumulated partial-denitrification (PD) and anammox in a continuously fed upflow anaerobic sludge blanket (UASB) reactor was verified for simultaneous nitrate (NO-N) and ammonia (NH-N) removal. A 225-days operation demonstrated that the relatively low total nitrogen (TN) concentration of 6.56 mg/L in effluent could be achieved with influent NH-N and NO-N both of 30 mg/L, resulting in a high TN removal of 89. Read More

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December 2018

Synthesis, photodynamic activities, and cytotoxicity of new water-soluble cationic gallium(III) and zinc(II) phthalocyanines.

J Inorg Biochem 2018 Dec 5;192:7-16. Epub 2018 Dec 5.

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan. Electronic address:

The cationic Ga(III) and Zn(II) phthalocyanines carrying N-methyl-pyridinium groups at eight peripheral β-positionshave been synthesized. These complexes are highly soluble in dimethyl sulfoxide (DMSO) and moderately soluble in water and phosphate buffered saline (PBS); both Ga(III)Cl and Zn(II) complexes have shown no aggregation in water up to 1.2 × 10 and 1. Read More

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December 2018

Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant.

Biomaterials 2018 Dec 10;193:1-11. Epub 2018 Dec 10.

Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address:

Mild heat stimulation can promote the restoration of bone defects but unfortunately, the delivery of exo-hyperthermy into human body is not efficient enough. In this study, mild heat-induced osteogenesis with high efficacy is demonstrated on an osteoimplant composed of black phosphorus nanosheets and poly(lactic-co-glycolic acid) (BPs@PLGA) with the participation of near-infrared (NIR) light irradiation. BPs@PLGA with only 0. Read More

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December 2018
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A comparative study of thermal stability of TNT, RDX, CL20 and ANTA explosives using UV 266nm-time resolved photoacoustic pyrolysis technique.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 6;211:212-220. Epub 2018 Dec 6.

Advanced Centre of Research in High Energy Materials (ACRHEM), University of Hyderabad, 500046, India. Electronic address:

The paper reports the potential use of UV based pulsed photoacoustic spectroscopy to study the thermal stability of some well-known premier explosives such as TNT, RDX, CL20, and ANTA between 30 and 350°C range. The thermal PA spectra of samples were recorded using fourth harmonic wavelength i.e. Read More

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December 2018

Expressions of homeobox, collagen and estrogen genes in women with uterine prolapse.

Eur J Obstet Gynecol Reprod Biol 2018 Nov 29;233:26-29. Epub 2018 Nov 29.

Ankara University, School of Medicine, Department of Biostatistics, Ankara, Turkey.

Objective: Genetic contribution is thought to be involved in the pathophysiology of pelvic organ prolapse (POP). We aimed to study the gene expression profiles of the genes HomeoboxA11 (HOXA11), HomeoboxA13 (HOXA13), Collagen Type I (COL1A), Collagen Type III (COL3A), estrogen receptor genes (ESR1 and ESR2) of round (RL) and uterosacral ligaments (USL) in postmenopausal women with uterine prolapse.

Study Design: Gene expressions of 32 postmenopausal women with prolapse were analysed according to gene expressions of 8 postmenopausal women without prolapse. Read More

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November 2018

Microcontainers for protection of oral vaccines, in vitro and in vivo evaluation.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Department of Micro- and Nanotechnology, Technical University of Denmark, Oersteds Plads 345C, 2800 Kgs., Lyngby, Denmark.

Oral vaccines are highly desirable due to simple logistics, mass vaccination potential and for mucosal immunity. Subunit vaccines are preferred due to high safety, but are inherently difficult to deliver orally, thus providing motivation for the use of advanced oral delivery systems. Polymeric devices in micrometer size (microcontainers) were tested here for this purpose. Read More

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December 2018
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Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura 285-8741, Japan. Electronic address:

Background: The levels of plasma sLR11, released from intimal SMCs, are positively associated with intima-media thickness (IMT) in asymptomatic subjects. We have evaluated the yet unknown pathological significance of sLR11 for plaque conditions in patients with carotid artery stenosis.

Methods: The presence of LR11 in carotid plaques was investigated using autopsy specimens. Read More

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December 2018

Evaluation of three advanced methodologies, COLD-PCR, microarray and ddPCR, for identifying the mutational status by liquid biopsies in metastatic colorectal cancer patients.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

Unit of Genomic for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy; Laboratory of Clinical Molecular Biology, IRCCS Ospedale San Raffaele, Milan, Italy; Università Vita-Salute San Raffaele, Milano, Italy.

A major effort has been focused on the detection of oncogenes' mutations in diverse types of clinical specimens including formalin-fixed and paraffin embedded tissues, presently the gold-standard samples, up to plasma, that constitute a noninvasive alternative source of tumor DNA. The reliable detection of mutations in circulating tumor DNA requires a high analytical sensitivity. Here, we applied three different highly sensitive methodologies (COLD-PCR, a microarray-based approach and the droplet digital PCR, ddPCR) to identify mutations in the plasma of 30 metastatic colorectal cancer patients previously genotyped on tissue biopsy. Read More

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December 2018

Environmental fate of pharmaceutical compounds and antimicrobial-resistant bacteria in hospital effluents, and contributions to pollutant loads in the surface waters in Japan.

Sci Total Environ 2018 Dec 3;657:476-484. Epub 2018 Dec 3.

Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

Environmental fate of 58 pharmaceutical compounds (PhCs) grouped into 11 therapeutic classes in the three different waters, hospital effluent, sewage treatment plant (STP) and river water, was estimated by combination of their quantitative concentration analysis and evaluation of their extent of contribution as loading sources. At the same time, distribution of six classes of antimicrobial-resistant bacteria (AMRB) in the same water samples was estimated by screening of individual PhC-resistant microbes grown on each specific chromogenic medium. The results indicate that 48 PhCs were detected ranged from 1 ng/L (losartan carboxylic acid) to 228 μg/L (acetaminophen sulfate) in hospital effluent, and contribution of the pollution load derived from hospital effluent to STP influent was estimated as 0. Read More

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December 2018

Synchronization-induced spike termination in networks of bistable neurons.

Neural Netw 2018 Nov 27;110:131-140. Epub 2018 Nov 27.

Department of Physics and Astronomy and The Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA.

We observe and study a self-organized phenomenon whereby the activity in a network of spiking neurons spontaneously terminates. We consider different types of populations, consisting of bistable model neurons connected electrically by gap junctions, or by either excitatory or inhibitory synapses, in a scale-free connection topology. We find that strongly synchronized population spiking events lead to complete cessation of activity in excitatory networks, but not in gap junction or inhibitory networks. Read More

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November 2018

Induction of protective immunity by recombinant peptidoglycan associated lipoprotein (rPAL) protein of Legionella pneumophila in a BALB/c mouse model.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Microbiology, Faculty of Advanced Sciences, Medical Sciences University Islamic Azad, Tehran, Iran.

Legionella pneumophila causes a severe form of pneumonia known as Legionnaires' disease especially in patients with impaired cellular immune response. In order to prevent the disease, immunogenicity and the level of the induction of protective immunity from the recombinant peptidoglycan-associated lipoprotein (rPAL) against Legionella pneumophila in BALB/c mice was examined. Mice immunized with (rPAL) rapidly increased an antibody response in serum and also displayed a strong activation of both innate and adaptive cell-mediated immunity as determined by antigen-specific splenocyte proliferation, an early production of pro-inflammatory cytokines in the serum and in the splenocyte cultures. Read More

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December 2018
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A scoping review to map empirical evidence regarding key domains and questions in the clinical pathway of delirium in palliative care.

J Pain Symptom Manage 2018 Dec 11. Epub 2018 Dec 11.

Division of Palliative Care, Dept of Medicine, University of Ottawa; Ottawa, ON, Canada; Bruyère Continuing Care; Ottawa, ON, Canada; Bruyère Research Institute; Ottawa, ON, Canada; Ottawa Hospital Research Institute; Ottawa, ON, Canada.

Context: Based on the clinical care pathway of delirium in palliative care (PC), a published analytic framework (AF) formulated research questions in key domains and recommended a scoping review to identify evidence gaps.

Objectives: To produce a literature map for key domains of the published AF: screening; prognosis and diagnosis; management and the health-related outcomes.

Methods: A standard scoping review framework was used by an interdisciplinary study team of nurse and physician delirium researchers, an information specialist and review methodologists to conduct the review. Read More

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December 2018

Advanced chemical peels: phenol-croton oil peel.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Once considered the gold standard for deep facial resurfacing, the classical Baker-Gordon phenol-croton oil peel has largely been replaced by formulas with lower concentrations of phenol and croton oil. The improved safety profile of deep peels has ushered in a new era in chemical peeling. Wrinkles can be improved and skin tightened with more subtle and natural results. Read More

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December 2018
2 Reads

A ball milling-based one-step transformation of chitin biomass to organo-dispersible strong nanofibers passing highly time and energy consuming processes.

Int J Biol Macromol 2018 Dec 11. Epub 2018 Dec 11.

Research Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan 44429, Republic of Korea; Advanced Materials and Chemical Engineering, University of Science and Technology (UST), Daejeon 34113, Republic of Korea. Electronic address:

Chitin, a sustainable and functional biological macromolecule, can be converted into chitin nanofibers (ChNFs), and are applicable as a mechanically reinforcing and bioactive filler for polymer matrices. Improving the performance of ChNFs typically relies on their nanofibrilization and miscibility with matrices. To transform chitin biomass into organo-dispersible ChNFs, a series of time-/energy-consuming chemical and mechanical treatments are required: 1) deacetylation, 2) disintegration, 3) surface modification to minimize their aggregation through hydrogen bonds, 4) drying, and 5) re-dispersion. Read More

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December 2018
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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Cell 2018 Dec;175(7):1756-1768.e17

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:

Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Read More

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December 2018
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De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 Dec 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

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December 2018

Mechanisms of acquired resistance to afatinib clarified with liquid biopsy.

PLoS One 2018 14;13(12):e0209384. Epub 2018 Dec 14.

Department of Internal Medicine, Division of Hematology, Respiratory Medicine and Oncology, Faculty of Medicine, Saga University, Saga, Japan.

Although mechanisms of acquired resistance to 1st and 3rd generation EGFR-TKI continue to be elucidated, there have been few clinical investigations into the mechanisms of acquired resistance to the 2nd generation EGFR-TKI afatinib. We analyzed data from 20 patients with advanced lung adenocarcinoma who acquired resistance to afatinib, including resistance during EGFR-TKI re-challenge. We examined EGFR T790M and C797S mutations, BRAF V600E mutation, and MET amplification with the MBP-QP method and with droplet digital PCR using ctDNA and re-biopsy samples obtained before and after afatinib treatment. Read More

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December 2018
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A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1.

PLoS One 2018 14;13(12):e0208979. Epub 2018 Dec 14.

Chemistry and Biology of Metals, Univ. Grenoble Alpes, CNRS UMR5249, CEA, BIG-LCBM, Grenoble, France.

LIM kinases are located at a strategic crossroad, downstream of several signaling pathways and upstream of effectors such as microtubules and the actin cytoskeleton. Cofilin is the only LIM kinases substrate that is well described to date, and its phosphorylation on serine 3 by LIM kinases controls cofilin actin-severing activity. Consequently, LIM kinases inhibition leads to actin cytoskeleton disorganization and blockade of cell motility, which makes this strategy attractive in anticancer treatments. Read More

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December 2018

Dissecting the regulation and function of ATP at the single-cell level.

PLoS Biol 2018 Dec 14;16(12):e3000095. Epub 2018 Dec 14.

Center for Quantitative Biology and Peking-Tsinghua Joint Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Regulation of cellular ATP level is critical for diverse biological processes and may be defective in diseases such as cancer and mitochondrial disorders. While mitochondria play critical roles in ATP level regulation, we still lack a systematic and quantitative picture of how individual mitochondrial-related genes contribute to cellular ATP level and how dysregulated ATP levels may affect downstream cellular processes. Advances in genetically encoded ATP biosensors have provided new opportunities for addressing these issues. Read More

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December 2018

Health Optimization Program for Elders: Improving the Transition From Hospital to Skilled Nursing Facility.

J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine (Drs Krol, Jolly Graham, and White and Mr English), Center for Advanced Clinical Practice (Ms Allen), and Duke University School of Nursing (Ms Matters), Duke University Medical Center, Durham, North Carolina.

Background: Individuals discharged from the hospital to skilled nursing facilities (SNFs) experience high rates of unplanned hospital readmission, indicating opportunity for improvement in transitional care.

Local Problem: Local physicians providing care in SNFs were not associated with the discharging hospital health care system. As a result, substantive real-time communication between hospital and SNF physicians was not occurring. Read More

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December 2018

Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Associated Mortality.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

Background: Mycobacterium avium complex (MAC) prophylaxis is recommended for patients with advanced HIV infection. With the decrease in incidence of disseminated MAC infection and the availability of antiretroviral therapy (ART), the benefits of macrolide prophylaxis were investigated. This study examined the impact of macrolide prophylaxis on AIDS-defining conditions and HIV-associated mortality in a cohort of HIV-infected patients on ART. Read More

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December 2018

Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery.

Anesth Analg 2019 Jan;128(1):33-42

Department of Perioperative Medicine, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.

Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and hospital and intensive care unit length of stay. Despite progressive improvements in overall cardiac surgical operative mortality and postoperative morbidity, the incidence of poAF has remained unchanged at 30%-50%. A number of evidence-based recommendations regarding the perioperative management of atrial fibrillation (AF) have been released from leading cardiovascular societies in recent years; however, it is unknown how closely these guidelines are being followed by medical practitioners. Read More

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January 2019

Exploring the Delivery of Healthcare in the Police Detention Center Through Remote Presence Technology.

J Forensic Nurs 2018 Dec 13. Epub 2018 Dec 13.

Office of the Vice-President Research, University of Saskatchewan.

Introduction: There is overwhelming evidence to support the delivery of high-quality health service at a lower cost with the use of advanced technologies. Implementing remote presence technology to expand clinical care has been fraught with barriers that limit interprofessional collaboration and optimal client outcomes. In Canada, government ministries responsible for correctional services, policing, and health are well positioned to link federal, provincial, and regional services to enhance service delivery at the point of care for individuals detained within the justice system. Read More

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December 2018
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Osseointegrated Percutaneous Prosthetic System for the Treatment of Patients With Transfemoral Amputation: A Prospective Five-year Follow-up of Patient-reported Outcomes and Complications.

J Am Acad Orthop Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Centre for Advanced Reconstruction of Extremities (C.A.R.E.), Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Brånemark, Dr. Hagberg, Mrs. Kulbacka-Ortiz, and Dr. Berlin), International Centre for Osseointegration Research, Education and Surgery (iCORES), Department of Orthopaedics, University of California, San Francisco, CA (Dr. Brånemark), and the Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Rydevik).

Introduction: Direct skeletal attachment of prostheses has previously been shown to improve patient-reported outcome (PRO) measures of individuals with transfemoral amputation (TFA) at 2-year follow-up. This prospective study reports the outcomes at 5-year follow-up.

Methods: A total of 51 patients (55 legs) with TFA were included in a prospective study. Read More

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December 2018

Analysis of nurse practitioner scope of practice in Taiwan using the Longest policy cycle model.

J Am Assoc Nurse Pract 2018 Dec 12. Epub 2018 Dec 12.

School of Nursing, National Yang Ming University, Taipei City, Taiwan.

Background And Purpose: To date, there has been no policy analysis or review of the effectiveness of the current nurse practitioner (NP) scope of practice regulations in Taiwan. The purpose is of this article was to provide a policy analysis of the NP scope of practice regulations in Taiwan.

Methods: The Longest policy cycle model was used to analyze the NP scope of practice regulations. Read More

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December 2018

Pressure-induced mesenchymal stem cell osteogenesis is dependent on intermediate filament remodeling.

FASEB J 2018 Dec 14:fj201801474RR. Epub 2018 Dec 14.

Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Macroscale loading of bone generates a complex local mechanical microenvironment that drives osteogenesis and bone mechanoadaptation. One such mechanical stimulus generated is hydrostatic pressure (HP); however, the effect of HP on mesenchymal stem cells (MSCs) and the mechanotransduction mechanisms utilized by these cells to sense this stimulus are yet to be fully elucidated. In this study, we demonstrate that cyclic HP is a potent mediator of cytoskeletal reorganization and increases in osteogenic responses in MSCs. Read More

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December 2018

Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in the United States.

Curr Med Res Opin 2018 Dec 14:1-16. Epub 2018 Dec 14.

e Global Health Economics, Amgen Inc. , Thousand Oaks , CA , USA.

Objective: Bone metastases are common among patients with advanced breast cancer, putting patients at increased risk of skeletal-related events (SREs). This study described impact of bone metastases, utilization of bone-targeted agents (BTAs) and physicians' decision processes for BTA use in advanced breast cancer.

Methods: Data were collected using the Adelphi Breast Cancer Disease-Specific Programme in the United States. Read More

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December 2018
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"Wisdom, bias, and balance: Toward a process-sensitive measurement of wisdom-related cognition": Correction to Brienza et al. (2017).

Authors:

J Pers Soc Psychol 2018 Dec;115(6):943

Reports an error in "Wisdom, bias, and balance: Toward a process-sensitive measurement of wisdom-related cognition" by Justin P. Brienza, Franki Y. H. Read More

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December 2018
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Hyperbolic phonon polaritons in suspended hexagonal boron nitride.

Nano Lett 2018 Dec 14. Epub 2018 Dec 14.

Highly-confined and low-loss hyperbolic phonon polaritons in hexagonal boron nitride possess properties analogous to surface plasmon polaritons, but with enhanced confinement and lower loss. Their properties have been so far mostly studied on dielectric substrates, which provide an asymmetric environment for polariton propagation, and add to damping. In this work, we investigate hyperbolic phonon polaritons over suspended hexagonal boron nitride, showing remarkable properties, including elongated polariton wavelength and reduced damping, up to 18% lower compared to dielectric-backed samples. Read More

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December 2018

Structural and Physical Properties of ZrSi under High Pressure: Experimental Study and First-Principles Calculations.

Inorg Chem 2018 Dec 14. Epub 2018 Dec 14.

High Pressure Science and Engineering Center , University of Nevada, Las Vegas , Las Vegas , Nevada 89154 , United States.

Zirconium disilicide (ZrSi) has been investigated experimentally and theoretically for its structural and physical properties at high pressures. In situ compression experiments demonstrate that at low pressure, ZrSi adopts the C49 structure (space group Cmcm), which persists up to 54.5 GPa at room temperature, and the unit cell of ZrSi along b-axis is at least twice as compressible as along a- and c-axis. Read More

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December 2018

Bacterial Resistance and Prostate Cancer Susceptibility Toward Metal-Ion-doped DNA Complexes.

ACS Appl Mater Interfaces 2018 Dec 14. Epub 2018 Dec 14.

Sungkyunkwan Advanced Institute of Nanotechnology (SAINT) and Department of Physics , Sungkyunkwan University , Suwon 16419 , Korea.

DNA nanotechnology has laid a platform to construct a variety of custom-shaped nanoscale objects for functionalization of specific target materials to achieve programmability and molecular recognition. Herein, we prepared DNA nanostructures [namely, synthetic DNA rings (RDNA) and DNA duplexes extracted from salmon (SDNA)] containing metal ions (M) such as Cu, Ni, and Zn as payloads for delivery to exterminate highly pathologic hospital bacterial strains (e.g. Read More

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December 2018
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Sugar Concentration and Arrangement on the Surface of Glycopolymer Micelles Affect the Interaction with Cancer Cells.

Biomacromolecules 2018 Dec 14. Epub 2018 Dec 14.

Centre for Advanced Macromolecular Design (CAMD), School of Chemistry , University of New South Wales , Sydney NSW 2052 , Australia.

Glycopolymer-coated nanoparticles have attracted significant interest over the past few years, because of their selective interaction with carbohydrate receptors found on the surface of cells. While the type of carbohydrate determines the strength of the ligand-receptor interaction, the presentation of the sugar can be highly influential as the carbohydrate needs to be accessible in order to display good binding. To shine more light on the relationship between nanoparticle structure and cell uptake, we have designed several micelles based on fructose containing block copolymers, which are selective to GLUT5 receptors found on breast cancer cell lines. Read More

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December 2018

[Analysis of distant metastasis and related factors of head and neck mucosal melanoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1078-1081

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100010, China.

To analyze the characteristics and related factors of distant metastasis of head and neck mucosal melanoma, so as to provide better help for the treatment and the control of patients' survival. Retrospectively analyze the patients of head and neck mucosal melanoma who were treated in our hospital from January 2004 to December 2016, through follow-up, of which 37 cases of patients with metastatic disease were analyzed which including the incidence of distant metastasis, specific metastasis and prognosis, time, etc.The age and gender of the patients were controlled, and 37 cases of 1∶1 were selected randomly in the patients who had no distant metastasis. Read More

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[BABA of da Vinci robot thyroid surgery in the standard treatment of thyroid cancer surgery].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1071-1074

Departmeng of Thyroid and Breast Surgery, Jinan Military General Hospital, Jinan, 250031, China.

Thyroid cancer is the most common malignant tumor in endocrine surgery. Surgery is the first choice for most patients with thyroid cancer. Da Vinci robot system as the auxiliary system is the most advanced endoscopic surgery, largely to fill the cavity mirror device cannot bend, complex operation and so on insufficiency, has now become an important way of surgical treatment of thyroid cancer, and its curative effect, high safety, but because of the economic cost is higher, is currently not widespread popularity. Read More

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July 2018
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Functional, nutritional and social factors associated with mobility limitations in the elderly: a systematic review.

Salud Publica Mex 2018 Sep-Oct;60(5):579-585

Postgraduate Program in Collective Health, Odontology Department, Federal University of Rio Grande do Norte. Natal, Brazil.

Objective: To systematically review the prevalence and incidence of mobility limitations in the elderly people and their associated factors.

Materials And Methods: Articles in the electronic literature were searched via PubMed, Scopus,,Lilacs, SciELO, PAHO, MedCarib, Repidisca, Wholis, IBCES, PEDro, Medline and Bireme (2012-2016). The instrument STROBE was used to analyze the quality of the work and the PRISMA recommendation was used to structure the review. Read More

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September 2017

Hybrid ablation under intraoperative 3D voltage mapping guidance.

Multimed Man Cardiothorac Surg 2018 Dec 10;2018. Epub 2018 Dec 10.

Long-standing persistent atrial fibrillation remains a significant therapeutic challenge, often proving to be resistant to treatment with antiarrhythmic medications and transcatheter ablation. Hybrid ablation, which combines a minimally invasive surgical and transcatheter approach, is emerging as a promising treatment option. In this video tutorial, we demonstrate our method of hybrid ablation for long-standing persistent atrial fibrillation using advanced 3D electro-anatomical voltage mapping to guide the ablation process and thereby improve the ultimate effectiveness of the procedure. Read More

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December 2018

Preoperative serum albumin as a predictor of complications following total hip replacement in patients with rheumatoid arthritis.

Acta Ortop Mex 2018 Jul-Aug;32(4):193-197

Trauma and Orthopaedic Surgery Hospitals. UMAE «Dr. Victorio de la Fuente Narváez», Mexico City.

Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by polyarthritis with progressive articular wear, immunologic abnormalities and increasing physical limitation. Surgical correction with hip replacement comes as a successful solution for patients with advanced articular destruction. Following intervention, surgical site infection (SSI), venous thromboembolism, sepsis, renal and major cardiovascular complications are among the most cited in the literature. Read More

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December 2018

Metabolic Syndrome in Dutch Patients With Bipolar Disorder: A Cross-Sectional Study.

Prim Care Companion CNS Disord 2018 Dec 6;20(6). Epub 2018 Dec 6.

Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands.

Objective: To characterize the prevalence of metabolic syndrome (MetS) among Dutch patients with bipolar disorder (BD), identify factors associated with MetS, and estimate the rate of pharmacologic treatment of MetS in this population.

Methods: A cross-sectional analysis of medical records of adult patients (≥ 18 years) with BD receiving psychotropic drug treatment was performed in a Dutch psychiatric outpatient setting. MetS was determined according to National Cholesterol Education Program Adult Treatment Panel III-Adapted (NCEP ATP III-A) criteria. Read More

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December 2018
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Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer.

Small 2018 Dec 14:e1804191. Epub 2018 Dec 14.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, P. R. China.

Gastric cancer remains one of the most lethal cancers with high incidence and mortality worldwide. The majority of gastric cancer patients are those who have first been diagnosed in advanced stage, in which the standard chemo-radiotherapy produces limited benefit along with severe general toxicity, thus the demand for improved therapeutic efficacy and decreased side effects drives the development of novel therapeutic strategies. Here, a neoadjuvant chemotherapy based on Abraxane/human neutrophils (NEs) cytopharmaceuticals with radiotherapy is presented for effective cancer treatment. Read More

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December 2018

Could transanal approach be the future treatment of a non-healing colorectal anastomotic leakage?

Colorectal Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgical Endoscopy, University "Federico II" of Naples, Via Pansini, 5, 80131, Naples, Italy.

We read with interest the article by Daprì et al, in which two anastomotic leaks after rectal surgery were treated by transanal approach, using a reusable transanal D-port and 5-mm reusable monocurved instruments according to DAPRI (Karl-Storz Endoskope). We describe a case in which we successful performed a transanal repair of an anastomotic leakage after rectal surgery. Even if a prospective trial is needed to prove the safety and feasibility of this technique, according to our results and the previous literature, a transanal minimally invasive approach could be adopted in the management of anastomotic leakage. Read More

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December 2018

A Three-dimensional Dynamic Supramolecular "Sticky Fingers" Organic Framework.

Angew Chem Int Ed Engl 2018 Dec 14. Epub 2018 Dec 14.

SPAIN.

Engineering high recognition host-guest materials is a burgeoning area in basic and applied research. The challenge of exploring novel porous materials with advanced functionalities, prompted us to develop dynamic crystalline structures promoted by soft interactions. Herein, we demonstrate the first example of a pure molecular dynamic crystalline framework held together by means of weak "sticky fingers" van der Waals interactions. Read More

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December 2018

Communicative Hand-Waving Gestures Facilitate Object Learning in Preverbal Infants.

Dev Sci 2018 Dec 14:e12787. Epub 2018 Dec 14.

Department of Psychology, Otemon Gakuin University, 2-1-15 Nishiai, Ibaraki, Osaka, 567-8502, JAPAN.

The theory of natural pedagogy has proposed that infants can use ostensive signals, including eye contact, infant-directed speech, and contingency to learn from others. However, the role of bodily gestures, such as hand-waving, in social learning has been largely ignored. To address this gap in the literature, this study sought to determine whether 4-month-old infants exhibited a preference for horizontal or vertical (control) hand-waving gestures. Read More

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December 2018
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