535,137 results match your criteria Advanced Steel Construction[Journal]


A novel organic-inorganic hybrid K-HBPE@APP performing excellent flame retardancy and smoke suppression for polypropylene.

J Hazard Mater 2019 Apr 4;373:856-865. Epub 2019 Apr 4.

Key Laboratory of Interface Science and Engineering in Advanced Materials (Taiyuan University of Technology), Ministry of Education, Taiyuan 030024, PR China; College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China.

To overcome the flammability and severe dripping of polypropylene (PP), a novel organic-inorganic hybrid K-HBPE@APP (microencapsulated APP by a hyperbranched polyester (HBPE) via silane coupling agent (KH-550)) was obtained and used as a high-efficient flame retardant and smoke suppressant. Herein, HBPE acted as the charring agent for APP. 20 wt% of K-HBPE@APP imparted PP excellent flame retardancy, V-0 rating (UL-94 test) and 82. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.016DOI Listing

Mechanical modeling of pimple growth.

J Mech Behav Biomed Mater 2019 Apr 16;95:191-195. Epub 2019 Apr 16.

Advanced Materials for Energy and Environment, Department of Earth and Environmental Engineering, Columbia University, New York, NY, 10027, USA; School of Chemical Engineering, Northwest University, Xi'an, 710069, PR China.

Pimple is one of the most common skin diseases for humans, whose growth cause pain yet the corresponding mechanical analysis is lacking. A finite element model is developed to quantify the deformation field with the expansion of follicle, and then the mechanical stimulus is related to the sensation of pain during the development of pimple. Parametric studies show the dependence of mechanical stimulus and pain level on the pimple-surrounded structures, follicle depth and mechanical properties of the epidermis. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.04.017DOI Listing

A De Novo Sphenoparietal Dural Arteriovenous Fistula: Unveiling The Deceitful Culprit.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Baptist Neurological Institute Lyerly Neurosurgery Department of Cerebrovascular Neurosurgery Jacksonville, Florida USA.

Introduction: Intracranial dural arteriovenous fistulas (DAVFs) are an uncommon pathology, and a sphenoparietal drainage pattern is certainly rare. We present a case of a de novo sphenoparietal dural arteriovenous fistula (DAVF) in a pre-pubsecent pediatric patient previously treated for a cerebellar arteriovenous malformation (AVM) 10 years before.

Case Description: A 10 year old male presented with worsening headaches for the past few weeks, swelling of the right side of face and eye, chemosis and proptosis of the right eye. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.120DOI Listing

The Utility of MRI Results in Physician Decision Making Prior to Initial Lumbar Spinal Injection.

Spine J 2019 Apr 19. Epub 2019 Apr 19.

University of Colorado Department of Physical Medicine and Rehabilitation, 12631 E. 17th Avenue, Mail Stop F493, Academic Office 1 (AO1), Room 2510, Aurora, Colorado 80045, US.

Background Context: The need for advanced imaging prior to spinal intervention is an area of ongoing debate. Many studies have demonstrated the accuracy of MRI results in evaluating structural pathology in the lumbar spine, but few have addressed how frequently MRI findings change clinical management. A randomized controlled trial showed that viewing MRI results did not impact outcomes in patients with radiculopathy undergoing epidural steroid injection (ESI). Read More

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http://dx.doi.org/10.1016/j.spinee.2019.04.016DOI Listing

Origin and evolution of core components responsible for monitoring light environment changes during plant terrestrialization.

Mol Plant 2019 Apr 19. Epub 2019 Apr 19.

School of Advanced Agriculture Sciences and School of Life Sciences, State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing 100871, China. Electronic address:

Light serves as the source of energy as well as information signals for photosynthetic plants. During evolution, plants have acquired the ability to monitor environmental light radiation and adjust their developmental patterns to optimally utilize light energy for photosynthesis. The mechanisms of light perception and signal transduction have been comprehensively studied in the past decades, mostly in a few model plants, including Arabidopsis thaliana. Read More

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http://dx.doi.org/10.1016/j.molp.2019.04.006DOI Listing

Kuntai capsule attenuates premature ovarian failure through the PI3K/AKT/mTOR pathway.

J Ethnopharmacol 2019 Apr 19:111885. Epub 2019 Apr 19.

Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, 210023, China; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address:

Ethnopharmacological Relevance: Kuntai capsule (KTC), a type of herb formulas, was first described in the book of Shang Han Za Bing Lun in the third century. KTC has been widely used for the clinical treatment of menopausal syndrome. Considering that premature ovarian failure is also known as premature menopause, this study was designed to investigate the effects and mechanisms of KTC on a mouse model of premature ovarian failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183378
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http://dx.doi.org/10.1016/j.jep.2019.111885DOI Listing
April 2019
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The EXACT protocol: a multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Epidemiology and Preventive Medicine, Monash University, Australia; Prehospital, Resuscitation and Emergency Care Research Unit, Curtin University, Australia; Alfred Hospital, Australia; Ambulance Victoria, Australia; Department of Community Emergency Health and Paramedic Practice, Monash University, Australia; SA Ambulance Service, Australia; Flinders University, Australia; St John Ambulance Western Australia, Australia; Warwick University, United Kingdom.

Background: Experimental and observational research suggests hyperoxia following resuscitation from cardiac arrest is associated with neurological injury and worse clinical outcomes. This paper describes the rationale and design of the EXACT trial. EXACT aims to determine whether reducing oxygen in the acute phase of post-resuscitation care for out-of-hospital cardiac arrest (OHCA) improves survival. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.023DOI Listing

Diffusion MRI using two-dimensional single-shot radial imaging (2D ss-rDWI) with variable flip angle and random view ordering.

Magn Reson Imaging 2019 Apr 19. Epub 2019 Apr 19.

Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States of America; Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States of America. Electronic address:

Purpose: The main objective of this study is to develop a 2D single-shot radial-DWI (2D ss-rDWI) technique to reduce motion artifacts and geometric distortion in DW images.

Method: A diffusion-preparation module is developed and applied prior to the data acquisition. Because the diffusion-prepared longitudinal magnetization is measured over multiple RF excitations in each shot, 2D ss-rDWI is subject to low signal-to-noise ratio (SNR). Read More

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http://dx.doi.org/10.1016/j.mri.2019.04.008DOI Listing

Anatomical location of primary melanoma: survival differences and sun exposure.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Victorian Melanoma Service, Alfred Hospital, Melbourne, Victoria, Australia.

Background: Anatomical location of melanoma has been demonstrated to independently influence melanoma specific survival (MSS).

Objective: We aimed to compare the MSS of specific anatomical subsites and between chronically, intermittently and rarely sun-exposed sites METHODS: A prospective cohort study was performed of primary invasive cutaneous melanomas with known thickness and location reviewed at a tertiary referral centre over 21 years.

Results: 3570 primary cutaneous invasive melanoma cases were included. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.034DOI Listing

Diabetic retinopathy: Focus on NADPH oxidase and its potential as therapeutic target.

Eur J Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address:

Diabetic retinopathy is a common complication of diabetes that affects the retina due to a sustained high blood sugar level. Recent studies have demonstrated that high glucose-driven oxidative stress plays an important role in the microvascular complications of retina in diabetes. Oxidative stress occurs due to the excess of reactive oxygen species, which causes oxidative damage to retina, leading to the leak of tiny blood vessels, or acts as signaling molecules to trigger neovascularization, resulting in new fragile vessels. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.038DOI Listing

Artificial Neural Network Learns Clinical Assessment of Spasticity in Modified Ashworth Scale.

Arch Phys Med Rehabil 2019 Apr 19. Epub 2019 Apr 19.

Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. Electronic address:

Objective: To propose an artificial intelligence (AI)-based decision-making rule in modified Ashworth scale (MAS) that draws maximum agreement from multiple human raters and to analyze how various biomechanical parameters affect scores in MAS.

Design: Prospective observational study SETTING: Two university hospitals PARTICIPANTS: Hemiplegic adults with elbow flexor spasticity due to acquired brain injury INTERVENTION: Not applicable MAIN OUTCOME MEASURES: 28 rehabilitation doctors and occupational therapists examined MAS of elbow flexors in 34 subjects with hemiplegia due to acquired brain injury while the MAS score and biomechanical data (i.e. Read More

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http://dx.doi.org/10.1016/j.apmr.2019.03.016DOI Listing

Introducing Artur V. Cideciyan and Samuel G. Jacobson, the 2018 Recipients of the Proctor Medal.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1677-1679

Department of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1167/iovs.19-26884DOI Listing

The complex genetic architecture of shoot growth natural variation in Arabidopsis thaliana.

PLoS Genet 2019 Apr 22;15(4):e1007954. Epub 2019 Apr 22.

Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, 78000, Versailles, France.

One of the main outcomes of quantitative genetics approaches to natural variation is to reveal the genetic architecture underlying the phenotypic space. Complex genetic architectures are described as including numerous loci (or alleles) with small-effect and/or low-frequency in the populations, interactions with the genetic background, environment or age. Linkage or association mapping strategies will be more or less sensitive to this complexity, so that we still have an unclear picture of its extent. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007954DOI Listing

Liver Stiffness Measurement With FibroScan: Use the Right Probe in the Right Conditions!

Clin Transl Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Hepato-Gastroenterology Department, Angers University Hospital, Angers, France.

Introduction: FibroScan's M and XL probes give significantly different results, which could lead to misevaluation of liver fibrosis if the correct probe is not chosen. According to the manufacturer, the M probe should be used when the skin-liver capsule distance (SCD) is <25 mm, and the XL probe should be used when SCD is ≥25 mm. We aimed at validating this recommendation and defining the conditions of use for FibroScan probes in clinical practice. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000023DOI Listing

Evaluating the Impact of Variable Phosphorothioate Content in Tricyclo-DNA Antisense Oligonucleotides in a Duchenne Muscular Dystrophy Mouse Model.

Nucleic Acid Ther 2019 Apr 22. Epub 2019 Apr 22.

1 Université de Versailles St- Quentin, U1179 INSERM, UFR des Sciences de la Santé, Montigny le Bretonneux, France.

Antisense oligonucleotides (ASOs) hold promise for therapeutic splice switching correction for genetic diseases, in particular for Duchenne muscular dystrophy (DMD), for which ASO-exon skipping represents one of the most advanced therapeutic strategies. We have previously reported the therapeutic potential of tricyclo-DNA (tcDNA) in mouse models of DMD, highlighting the unique pharmaceutical properties and unprecedented uptake in many tissues after systemic delivery, including the heart and central nervous system. TcDNA-ASOs demonstrate an encouraging safety profile and no particular class-related toxicity, however, when administered in high doses for several months, mild renal toxicity is observed secondary to predictable phosphorothioate (PS)-ASO accumulation in kidneys. Read More

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https://www.liebertpub.com/doi/10.1089/nat.2018.0773
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http://dx.doi.org/10.1089/nat.2018.0773DOI Listing

Advancing Cancer Research in Africa Through Early-Career Awards: The BIG Cat Initiative.

J Glob Oncol 2019 Apr(5):1-8

5 National Institute of Mental Health, Bethesda, MD.

Purpose: The burden of cancer in Africa is growing rapidly, and increased cancer research on the continent is a critical component of an effective response. In 2010, the US National Cancer Institute, in partnership with the African Organization for Research and Training in Cancer, launched the Beginning Investigator Grant for Catalytic Research (BIG Cat) initiative to support cancer research projects conducted by early-career African investigators.

Methods: To date, BIG Cat has provided 18 awards of up to $50,000 to support 2-year cancer research projects. Read More

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http://dx.doi.org/10.1200/JGO.18.00223DOI Listing

Influence of the Urban Exposome on Birth Weight.

Environ Health Perspect 2019 Apr;127(4):47007

4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.

Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.

Objective: We evaluated the association of the urban exposome with birth weight. Read More

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http://dx.doi.org/10.1289/EHP3971DOI Listing

Law and Disorder: Special Stacking Units-Building the Intergrowth CeCoGe.

Inorg Chem 2019 Apr 22. Epub 2019 Apr 22.

Center for Nanophysics and Advanced Materials, Department of Physics , University of Maryland , College Park , Maryland 20742 , United States.

A new structure type of composition CeCoGe was grown out of a molten Sn flux. CeCoGe crystallizes in the orthorhombic space group Cmcm, with highly anisotropic lattice parameters of a = 4.3293(5) Å, b = 55. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00350DOI Listing

Real-Time Single-Walled Carbon Nanotube-Based Fluorescence Imaging Improves Survival After Debulking Surgery In An Ovarian Cancer Model.

ACS Nano 2019 Apr 22. Epub 2019 Apr 22.

Improved cytoreductive surgery for advanced stage ovarian cancer (OC) represents a critical challenge in the treatment of the disease. Optimal debulking reaching no evidence of macroscopic disease is the primary surgical endpoint with a demonstrated survival advantage. Targeted molecule-based fluorescence imaging offers complete tumor resection down to the microscopic scale. Read More

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http://dx.doi.org/10.1021/acsnano.8b09829DOI Listing

In vitro and in vivo assessment of CaP materials for bone regenerative therapy. The role of multinucleated giant cells/osteoclasts in bone regeneration.

J Biomed Mater Res B Appl Biomater 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Histology of Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla 9-75, Bauru, São Paulo 17012-901, Brazil.

In this work, bone formation/remodeling/maturation was correlated with the presence of multinucleated giant cells (MGCs)/osteoclasts (tartrate-resistant acid phosphatase [TRAP]-positive cells) on the surface of beta-tricalcium phosphate (β-TCP), sintered deproteinized bovine bone (sDBB), and carbonated deproteinized bovine bone (cDBB) using a maxillary sinus augmentation (MSA) in a New Zealand rabbit model. Microtomographic, histomorphometric, and immunolabeling for TRAP-cells analyses were made at 15, 30, and 60 days after surgery. In all treatments, a faster bone formation/remodeling/maturation and TRAP-positive cells activity occurred in the osteotomy region of the MSA than in the middle and submucosa regions. Read More

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http://dx.doi.org/10.1002/jbm.b.34388DOI Listing

Fibre hypertrophy, satellite cell and myonuclear adaptations to resistance training: Have very old individuals reached the ceiling for muscle fibre plasticity?

Acta Physiol (Oxf) 2019 Apr 22:e13287. Epub 2019 Apr 22.

Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.

In this issue of Acta Physiologica, Karlsen et al. report original data suggesting lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with 12 weeks of resistance training in very old (83-94-years) men and women. These findings further our understanding of muscle remodelling responses to exercise at the most advanced stages of ageing, and spur additional research on the optimization of training protocols to combat muscle loss. Read More

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http://dx.doi.org/10.1111/apha.13287DOI Listing

Role of cyclin-dependent kinases (CDKs) in hepatocellular carcinoma: therapeutic potential of targeting CDKs signaling pathway.

Hepatol Res 2019 Apr 22. Epub 2019 Apr 22.

Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.

Hepatocellular carcinoma (HCC) is a common malignancy of the liver and is the second leading cause of cancer-related mortalities. Two-thirds of patients have advanced disease when diagnosed, and for these patients, treatment strategies remain limited. In addition, there is a high incidence of tumor recurrence after surgical resection with the current treatment regimens. Read More

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http://dx.doi.org/10.1111/hepr.13353DOI Listing

Cholix toxin, an eEF2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.

Cell Microbiol 2019 Apr 22:e13033. Epub 2019 Apr 22.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Vibrio cholerae produced-Cholix toxin (Cholix) is a cytotoxin that ADP-ribosylates eukaryotic elongation factor 2, inhibiting protein synthesis, and inducing apoptosis. Here, we identified prohibitin (PHB) 1 and 2 as novel Cholix-interacting membrane proteins in immortalized human hepatocytes and HepG2 cells by Cholix immunoprecipitation assays. The expression level of PHB1 was decreased by Cholix after a 12 h incubation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13033
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http://dx.doi.org/10.1111/cmi.13033DOI Listing
April 2019
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Assessing the Impact of Renal Artery Clamping During Laparoscopic Partial Nephrectomy for Small Renal Masses: The Rationale and Design of the CLOCK II Randomized Phase III Trial.

BJU Int 2019 Apr 22. Epub 2019 Apr 22.

Unit of Urology, Spedali Civili Hospital, University of Brescia, Brescia, Italy.

An interplay among patient-related and surgery-related factors determine the functional recovery after partial nephrectomy (PN) [1]. The ischemic injury led by renal arterial clamping has historically been one of the major modifiable surgical factors responsible for the functional decrease after PN. As such, several techniques for minimizing or even eliminating the hilar clamping have been described [2]. Read More

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http://dx.doi.org/10.1111/bju.14779DOI Listing

np QTL: Networking phenotypic plasticity QTLs across heterogeneous environments.

Plant J 2019 Apr 22. Epub 2019 Apr 22.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing, 100083, China.

Despite its critical importance to our understanding of plant growth and adaptation, the question of how environment-induced plastic response is affected genetically remains elusive. Previous studies showed that the reaction norm of an organism across environmental index obeys the allometrical scaling law of part-whole relationships. The implementation of this phenomenon into functional mapping can characterize how quantitative trait loci (QTLs) modulate the phenotypic plasticity of complex traits to heterogeneous environments. Read More

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http://dx.doi.org/10.1111/tpj.14355DOI Listing

Peptoid microsphere coatings: The effects of helicity, temperature, pH, and ionic strength.

Biopolymers 2019 Apr 22:e23283. Epub 2019 Apr 22.

Ralph E. Martin Department of Chemical Engineering, University of Arkansas Fayetteville, Fayetteville, Arkansas.

Peptoids are peptidomimetic oligomers that predominantly harness similarities to peptides for biomimetic functionality. They have potential for use in biomedical applications and biosensors due to resistance to proteolytic degradation and low immunogenicity. The incorporation of chiral, aromatic side chains in the peptoid sequence allows for the formation of distinct secondary structures and self-assembly into supramolecular assemblies, including microspheres. Read More

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http://dx.doi.org/10.1002/bip.23283DOI Listing

Copula-based semiparametric models for spatio-temporal data.

Biometrics 2019 Apr 22. Epub 2019 Apr 22.

Department of Statistical Science, Baylor University, Waco, TX, 76798, USA.

The joint analysis of spatial and temporal processes poses computational challenges due to the data's high dimensionality. Furthermore, such data are commonly non-Gaussian. In this paper, we introduce a copula-based spatio-temporal model for analyzing spatio-temporal data and propose a semiparametric estimator. Read More

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http://dx.doi.org/10.1111/biom.13066DOI Listing

A Guide to Build a Highly Inclined Swept Tile Microscope for Extended Field-of-view Single-molecule Imaging.

J Vis Exp 2019 Apr 8(146). Epub 2019 Apr 8.

CREOL, The College of Optics and Photonics, University of Central Florida;

Single-molecule imaging has greatly advanced our understanding of molecular mechanisms in biological studies. However, it has been challenging to obtain large field-of-view, high-contrast images in thick cells and tissues. Here, we introduce highly inclined swept tile (HIST) microscopy that overcomes this problem. Read More

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http://dx.doi.org/10.3791/59360DOI Listing

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli.

J Vis Exp 2019 Apr 5(146). Epub 2019 Apr 5.

Department of Medical Psychology, Ulm University.

The assessment of pain relies mostly on methods that require a person to communicate. However, for people with cognitive and verbal impairments, existing methods are not sufficient as they lack reliability and validity. To approach this problem, recent research focuses on an objective pain assessment facilitated by parameters of responses derived from physiology, and video and audio signals. Read More

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http://dx.doi.org/10.3791/59057DOI Listing

Patient-tailored FOLFIRINOX as first line treatment of patients with advanced pancreatic adenocarcinoma.

Medicine (Baltimore) 2019 Apr;98(16):e15341

Assistance Publique-Hôpitaux de Paris, Department of Medical Oncology, Paul Brousse Hospital.

FOLFIRINOX is one of the most effective reference regimens in the 1st line treatment of locally advanced (LA) and metastatic pancreatic cancer (mPC), despite its high toxicity. We evaluated our real-life experience with "patient-tailored intent to treat FOLFIRINOX" in patients with LA or mPC compared to other reports along with the pivotal phase III trial.We analyzed data from all consecutive patients with pancreatic ductal adenocarcinoma treated with dose-modified FOLFIRINOX in 2016 at Paul Brousse University Hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000015341DOI Listing
April 2019
1 Read

Upregulation of lncRNA SNHG1 is associated with metastasis and poor prognosis in cancers: A meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15196

Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University.

Background: Accumulating evidence suggested that the expression level of long noncoding RNA small nucleolar RNA host gene 1 (lncRNA SNHG1) was upregulated in various cancers, and high expression of SNHG1 was associated with metastasis and prognosis in patients with cancer.The relationship between SNHG1 expression and metastasis or prognosis in malignant tumors was investigated in this meta-analysis.

Methods: A systematic search was performed in PubMed, Web of Science, and Cochrane Library from inception until May 31, 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000015196DOI Listing

Atypical case of posterior reversible encephalopathy syndrome related to late onset postpartum eclampsia: A case report.

Medicine (Baltimore) 2019 Apr;98(16):e15187

Advanced Emergency and Critical Care Medical Center, Okayama University Hospital, Okayama City, Okayama, Japan.

Rationale: Eclampsia, an obstetric emergency frequently seen in pregnant or puerperal women, is a risk factor for posterior reversible encephalopathy syndrome (PRES). Most cases of eclampsia occur postpartum. We report a woman with PRES associated with eclampsia 10 weeks post-delivery, the latest onset ever reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000015187DOI Listing

A case report on metastatic ileal neuroendocrine neoplasm to the breast masquerading as primary breast cancer: A diagnostic challenge and management dilemma.

Medicine (Baltimore) 2019 Apr;98(16):e14989

1st Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Rationale: Metastatic neuroendocrine neoplasms (NENs) to the breast are very rare entities comprising only 1% to 2% of all metastatic breast tumors. In this article, we describe a case of a neuroendocrine ileal neoplasm metastatic to breast and liver, with breast metastatic tumor to be the initial manifestation of the disease.

Patient Concerns: We herein report a rare case of a female patient admitted to our department with a palpable painful mass on her left breast. Read More

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http://dx.doi.org/10.1097/MD.0000000000014989DOI Listing
April 2019
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Risk factors of malignant fluorodeoxyglucose-avid lymph node on preablation positron emission tomography in patients with papillary thyroid cancer undergoing radioiodine ablation therapy.

Medicine (Baltimore) 2019 Apr;98(16):e14858

Department of Nuclear Medicine, Chonnam National University Hospital.

F-18 fluorodeoxyglucose (FDG)-avid metastatic lesions are associated with a poor response to radioiodine ablation therapy (RIT) in papillary thyroid cancer (PTC). This study evaluated the significance of preablative FDG positron emission tomography (PET) for the assessment of risk factors and frequency of malignant FDG-avid lymph nodes in patients with PTC undergoing RIT.The study included 339 consecutive patients (mean age 46. Read More

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http://dx.doi.org/10.1097/MD.0000000000014858DOI Listing

Deconstructing a Leader: An in Depth Analysis of the Commonalities Between Plastic Surgery Chiefs and Chairmen.

Plast Reconstr Surg 2019 Apr 15. Epub 2019 Apr 15.

Purpose: We sought to identify factors associated with current chiefs and chairpersons in academic plastic surgery to encourage and shape future leaders of tomorrow.

Methods: Academic chairpersons in plastic surgery (n = 94) were identified through an Internet-based search of all Accreditation Council for Graduate Medical Education-accredited residency training programs during the year of 2015. Gender, ethnicity, academic rank, board certification, time since certification, medical school attended, residency program attended, fellowships training, advanced degrees, obtaining leadership roles at trainee's institution, and h- index were analyzed. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005783DOI Listing

The DNP Degree: Are We Producing the Graduates We Intended?

J Nurs Adm 2019 May;49(5):280-285

Author Affiliations: Associate Professor (Dr Bowie), Professor (Dr DeSocio), Dean (Dr Swanson), Seattle University, College of Nursing, Washington.

Objective: This study addressed how recently graduated doctor of nursing practice (DNP) nurses describe their current practice, how their supervisors describe the DNP's current practice, and whether nurse and supervisor descriptions of the practices reflect the American Association of Colleges of Nursing (AACN) DNP Essentials and, if so, how?

Background: Introduced in 2004, the goal of DNP programs was to educate advanced practice RNs for effective leadership in complex healthcare environments. The value of the DNP degree for nurses in healthcare systems is evolving.

Methods: We used conventional content analysis to inductively describe how DNP graduates from 7 different schools and their supervisors described the practice of the recently graduated DNPs. Read More

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http://dx.doi.org/10.1097/NNA.0000000000000751DOI Listing
May 2019
1 Read

North Carolina Nurse Leader Project: A Replication Study to Assess Nurse Leadership Capacity.

J Nurs Adm 2019 May;49(5):256-259

Author Affiliations: Clinical Assistant Professor (Dr Williams), School of Nursing, University of North Carolina at Chapel Hill; Assistant Research Professor (Dr Li), School of Nursing, Emory University.

Objectives: The study examined nurse leader roles, barriers, and the need for nurse leader succession planning in North Carolina (NC).

Background: This study was conducted to assess leadership capacity in NC and further the efforts of the Future of Nursing report, which calls for nurses to lead change and advance health.

Methods: This study employed an exploratory research design using the Florida Action Coalition 56-item survey of active RNs and advanced practice RNs in NC. Read More

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http://dx.doi.org/10.1097/NNA.0000000000000747DOI Listing

Fostering Academic-Clinical Research Partnerships.

J Nurs Adm 2019 May;49(5):234-241

Author Affiliations: Associate Chief Nursing Officer, Nursing Research and Innovation, Nursing Institute, Cleveland Clinic, Ohio; and Adjunct Professor (Dr Albert), Aalborg University, Denmark; Clinical Nurse Scientist, Associate Professor of Clinical Nursing (Dr Chipps), The Ohio State University Wexner Medical Center, The Ohio State University College of Nursing, Columbus; Nurse Research Scientist (Dr Falkenberg Olson), Gundersen Health System-Gundersen Medical Foundation, La Crosse, Wisconsin; Director (Dr Hand), Office for Nursing Research and Scholarship, University of Iowa; Nurse Education Specialist-Clinical/Academic Liaison (Dr Harmon), Nursing Development & Research-Henry Ford Macomb, Clinton Township, Michigan; Director of Clinical Research, Rush University Medical Center, Rush Oak Park, and Assistant Professor and Codirector (Dr Heitschmidt), Center for Clinical Research and Scholarship, College of Nursing, Rush University, Chicago; Education and Research Scientist (Dr Klein), Advanced Practice, OSF HealthCare, Peoria; and Director (Dr Lefaiver), Advocate Center for Pediatric Research, Oak Lawn, Illinois; Program Manager (Dr Wood), Nursing Research, Nursing Research and Excellence Department, OhioHealth, Columbus.

Academic-clinical research partnerships can benefit academic and clinical partners when goals are clearly articulated and mutually determined and include increased research dissemination and lower research costs. This article explores the history of academic-clinical research partnerships and discusses the drivers of collaborative academic-clinical research relationships, resources from academia and clinical sites, and sustainability of collaborative partnerships. Through collaboration, academic-clinical partners can improve clinical outcomes and reduce healthcare costs. Read More

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http://dx.doi.org/10.1097/NNA.0000000000000744DOI Listing

Traditional healers, hiv outcomes, and mortality among people living with hiv in senegal, west africa.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Washington, Seattle, WA, USA.

Objectives: The goals of this study were to determine the frequency of traditional healer (TH) use among PLHIV in Senegal, to identify predictors of TH use, and to determine if TH use is associated with HIV outcomes.

Design: Prospective longitudinal study METHODS:: Subjects were enrolled from April 2017-April 2018 in Dakar and Ziguinchor, Senegal. Interviews, clinical evaluations, laboratory analyses, and chart review were conducted. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002232DOI Listing

Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

MRC Clinical Trials Unit at UCL, London, UK.

Objectives: A proportion of HIV-infected children with advanced disease develop severe malnutrition soon after antiretroviral therapy (ART) initiation. We tested the hypothesis that systemic inflammation underlies the pathogenesis of severe malnutrition in HIV-infected children.

Design: Cross-sectional laboratory sub-study in 613 HIV-infected children initiating ART in Uganda and Zimbabwe. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002231DOI Listing

An update in the management of pediatric sarcoma.

Curr Opin Pediatr 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Division of Pediatric Surgery, University of North Carolina Children's Hospital, Chapel Hill, North Carolina, USA.

Purpose Of Review: Nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) is a rare subgroup of malignancy in childhood that is composed of a variety of soft tissue and bony tumors. Prognosis for resectable localized disease is usually good and improved with systemic treatment. However, survival from locally advanced and metastatic disease remains poor. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000767DOI Listing

Self-directed interventions for gambling disorder.

Curr Opin Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Health and Environmental Sciences, National Institute for Public Health and Mental Health Research, Auckland University of Technology, Northcote, Auckland, New Zealand.

Purpose Of Review: To assess recent developments in self-directed interventions for gambling disorder and at-risk gambling.

Recent Findings: Relevant reviews and meta-analyses were published during 2017 and 2018. These reviews assess the nature and efficacy of self-directed and largely self-directed interventions including self-change, assisted self-change and mutual aid support groups. Read More

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http://dx.doi.org/10.1097/YCO.0000000000000515DOI Listing

Multicenter retrospective study to evaluate the impact of trabectedin plus pegylated liposomal doxorubicin on the subsequent treatment in women with recurrent, platinum-sensitive ovarian cancer.

Anticancer Drugs 2019 Apr 18. Epub 2019 Apr 18.

Navarra University Clinic Madrid.

Debulking surgery, followed by taxane/platinum-based chemotherapy has traditionally been the first-line treatment for advanced ovarian cancer. However, most patients will experience recurrence afterwards, and receive subsequent lines of therapy. It has been proposed that extending the treatment-free interval of platinum can improve the response to a subsequent platinum-based chemotherapy, and reduce associated toxicities in women with recurrent, platinum-sensitive ovarian cancer. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000794DOI Listing

Clinical Achievement of Wound Closure and Tissue Quality With a Novel Microvascular Tissue Graft.

Wounds 2019 Apr;31(4):E29-E32

The AngioGenesis Foundation, Cambridge, MA.

Introduction: Microvascular tissue serves as the foundation for tissue granulation and remodeling during the wound healing process. Optimal repair of microvascular structure and function is essential for future healing capacity and to minimize tissue breakdown in a newly epithelialized wound.

Objective: This case series of 3 patients with nonhealing diabetic foot ulcers (DFUs) refractory to standard wound care demonstrates the ability of processed microvascular tissue (PMVT) to enable wound closure, increase local perfusion and vascular maturity, and improve overall tissue quality. Read More

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Exploring Care Providers' Perceptions and Current Use of Telehealth Technology at Work, in Daily Life, and in Education: Qualitative and Quantitative Study.

JMIR Med Educ 2019 Apr 22;5(1):e13350. Epub 2019 Apr 22.

Nicole Wertheim College of Nursing & Health Sciences, Florida International University, Miami, FL, United States.

Background: A telehealth technology education curriculum designed to integrate information technology and telecommunication well has great potential to prepare care providers for health care delivery across space, time, and social and cultural barriers. It is important to assess the readiness level of care providers to use and maximize the benefits of telehealth technology in the health care delivery process. Therefore, this study explored care providers' existing experience using technology in various use contexts and compared their familiarity with telehealth technology's relevant features. Read More

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http://dx.doi.org/10.2196/13350DOI Listing

Visible-Light Excitation of Quinolinone-Containing Substrates Enables Divergent Radical Cyclizations.

Org Lett 2019 Apr 22. Epub 2019 Apr 22.

Center for Catalytic Hydrocarbon Functionalizations , Institute for Basic Science (IBS) , Daejeon 34141 , Korea.

Reported herein is the photochemical activity of quinolinone-containing substrates that directly reach an excited state upon light absorption to trigger radical-based bond-forming processes. The presented transformations allow divergent construction of valuable dihydro- or tetrahydrophenanthridin-6(5 H)-ones through the generation of S- or P-centered radicals, subsequent radical addition, cyclization, and a hydrogen atom transfer/electron transfer sequence. This strategy demonstrates the potential generality of quinolinone-tethered substrates to directly participate in the photoexcitation for the development of useful synthetic methods. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b01155DOI Listing

Safety-enhanced polymer electrolytes for sodium batteries: recent progresses and perspectives.

ACS Appl Mater Interfaces 2019 Apr 22. Epub 2019 Apr 22.

Sodium batteries (SBs) have aroused increasing attentions due to the abundance and low cost of elemental sodium. In recent decades, intensive efforts have been under way to exploit advanced SBs for practical applications. However, conventional liquid electrolytes used in SBs suffer from serious safety hazards (high volatility, inflammability and leakage), severe side reactions between electrodes and electrolytes, and inevitable sodium dendrite problems, which is greatly detrimental to battery performance. Read More

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http://dx.doi.org/10.1021/acsami.9b01239DOI Listing

A proposed technique to visualize and classify uterosacral ligament deep endometriosis with and without infiltration into the parametrium or torus uterinus.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Acute Gynecology, Early Pregnancy & Advanced Endoscopic Surgery Unit, Nepean Hospital, Sydney, Australia.

Deep endometriosis (DE) of the uterosacral ligaments (USLs) has been reported to be the most common site of DE in the pelvis . A nodule within the USL may infiltrate the parametrium, increasing the complexity of surgical resection and larger nodules noted on transvaginal ultrasound (TVS) (≥17mm) should raise suspicion for ureteral involvement . Nodules may also invade the torus uterinus, the thickening between the insertion of the USLs behind the posterior cervix. Read More

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http://dx.doi.org/10.1002/uog.20300DOI Listing

[Role of prostaglandin E2 receptor 4 in cardiovascular diseases].

Sheng Li Xue Bao 2019 Apr;71(2):361-370

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.

Prostaglandin E2 (PGE2) is a cyclooxygenase metabolite of arachidonic acid. It acts as a bioactive lipid and plays an important role in regulating many biological processes. PGE2 binds to 4 different G protein-coupled receptors including prostaglandin E2 receptor subtypes EP1, EP2, EP3 and EP4. Read More

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[Role of pregnane X receptor (PXR) in endobiotic metabolism].

Sheng Li Xue Bao 2019 Apr;71(2):311-318

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.

As a member of the nuclear receptor superfamily, the pregnane X receptor (PXR) is a ligand-activated transcription factor. PXR is highly expressed in liver and intestinal tissues, and also found in other tissues and organs, such as stomach and kidney. After heterodimerization with retinoid X receptor (RXR), PXR recruits numerous co-activating factors, and binds to specific DNA response elements to perform transcriptional regulation of the downstream target genes. Read More

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