605,215 results match your criteria Advanced Steel Construction[Journal]


[Paraneoplastic Cushing's syndrome as cause of refractory hypokalemia].

Dtsch Med Wochenschr 2020 Jun 3;145(11):783-786. Epub 2020 Jun 3.

Abteilung für Endokrinologie, Diabetologie und Metabolismus, Medizinische Universitätsklinik, Kantonsspital Aarau, Schweiz.

History:  A 58-year-old man presented with refractory hypokalemia and rapid weight gain. On examination, he had high blood pressure, central obesity and bilateral pitting edema.

Findings And Diagnosis:  Biochemical tests showed hypokalemic metabolic alkalosis due to ACTH-dependent hypercortisolism. Read More

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http://dx.doi.org/10.1055/a-1163-9873DOI Listing

[Antidiabetic SGLT-2 inhibitors prevent progression of chronic kidney disease].

Dtsch Med Wochenschr 2020 Jun 3;145(11):762-766. Epub 2020 Jun 3.

AGAPLESION MARKUS KRANKENHAUS, Medizinische Klinik II, Frankfurt am Main, Frankfurt.

Several interventional trials that studied cardiovascular safety of antidiabetic drugs in patients with diabetes mellitus and elevated risk of cardiovascular disease suggested potential nephroprotective effects of SGLT-2 inhibitors. Subsequently, the CREDENCE study confirmed reduced progression of chronic kidney disease (CKD) towards dialysis-dependency in diabetic patients with mildly or moderately impaired glomerular filtration rate and high albuminuria. Next, the DAPA-CKD and EMPA-KIDNEY studies were initiated to test whether SGLT-2-inhibitors will also affect CKD progression in (a) non-diabetic CKD patients, (b) in CKD patients without albuminuria and/or (c) in patients with advanced CKD. Read More

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http://dx.doi.org/10.1055/a-1163-7590DOI Listing

Glycoprotein VI is not a Functional Platelet Receptor for Fibrin Formed in Plasma or Blood.

Thromb Haemost 2020 Jun 3;120(6):977-993. Epub 2020 Jun 3.

Institute for Prevention of Cardiovascular Diseases, LMU (Ludwig-Maximilians University), Munich, Germany.

Glycoprotein VI (GPVI), a platelet collagen receptor, is crucial in mediating atherothrombosis. Besides collagen, injured plaques expose tissue factor (TF) that triggers fibrin formation. Previous studies reported that GPVI also is a platelet receptor for fibrinogen and fibrin. Read More

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http://dx.doi.org/10.1055/s-0040-1710012DOI Listing

SlBL4 regulates chlorophyll accumulation, chloroplast development and cell wall metabolism in tomato fruit.

J Exp Bot 2020 Jun 3. Epub 2020 Jun 3.

Key Laboratory of Plant Hormones and Development Regulation of Chongqing, School of Life Sciences, Chongqing University, Chongqing, China.

Tomato is a model for studying the climate for fruit development and ripening. Down-regulation of a tomato bell-like homeodomain 4 (SlBL4) resulted in a slightly darker green fruit phenotype and increased accumulation of starch, fructose and glucose. Chlorophyll content analysis and TEM observation confirmed these phenotypes, indicating that SlBL4 was involved in the chlorophyll accumulation and chloroplast formation in tomato. Read More

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http://dx.doi.org/10.1093/jxb/eraa272DOI Listing

Evaluation of Parametrial Status in Locally Advanced Cervical Cancer Patients after Neoadjuvant Chemotherapy: A Prospective Study on Diagnostic Accuracy of Three-Dimensional Transvaginal Ultrasound.

Oncology 2020 Jun 3:1-9. Epub 2020 Jun 3.

Department of Maternal and Child Health and Urological Sciences, University "Sapienza", Policlinico "Umberto I", Rome, Italy.

Objectives: To analyze the diagnostic accuracy of two-dimensional (2D) and three-dimensional transvaginal ultrasound (3D TV-US) for evaluation of parametrial status in locally advanced cervical cancer patients after neoadjuvant chemotherapy (NACT), using histology as the gold standard.

Methods: Consecutive patients with histologically confirmed cervical cancer were staged according to FIGO (International Federation of Gynaecology and Obstetrics) criteria. All IB2-IIIB FIGO stage patients were examined by 2D and 3D TV-US and magnetic resonance imaging (MRI) at the diagnosis time (T0) and after NACT. Read More

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http://dx.doi.org/10.1159/000506642DOI Listing

Temperature-programmable and enzymatically solidifiable gelatin-based bioinks enable facile extrusion bioprinting.

Biofabrication 2020 Jun 3. Epub 2020 Jun 3.

Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen, CHINA.

The development of exceptional bioinks with excellent printability, high fidelity, and excellent cell viability maintenance for extrusion bioprinting remains a major challenge. Gelatin is an ideal candidate bioink due to its biocompatibility, biodegradability, and non-immunogenicity. However, its inherently low viscosity and unstable physical gelation under physiological conditions make it unsuitable for direct extrusion bioprinting of tissue-like gelatin constructs with high fidelity. Read More

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http://dx.doi.org/10.1088/1758-5090/ab9906DOI Listing

Molecular Characteristics and Clinical Outcomes of EGFR Exon 19 C-Helix Deletion in Non-Small Cell Lung Cancer and Response to EGFR TKIs.

Transl Oncol 2020 May 31;13(9):100791. Epub 2020 May 31.

Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, People's Republic of China. Electronic address:

Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limited coverage of regular EGFR mutation testing. Here, we performed a retrospective cohort study of the C-helix E19del in advanced NSCLC patients based on the screening data by the next-generation sequencing (NGS) platform. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100791DOI Listing

Clinical use of vascular endothelial growth factor receptor inhibitors for the treatment of renal cell carcinoma.

Eur J Med Chem 2020 May 22;200:112482. Epub 2020 May 22.

Faculty of Life Science and Technology, Kunming University of Science and Technology, PR China. Electronic address:

In recent years, there have been increased incidences of metastatic renal cell carcinoma (RCC), which is refractory to conventional chemotherapy. Owing to the insensitivity to traditional therapy, targeted therapy becomes a possible alternative strategy. Over the past decade, the development of targeted treatments for metastatic RCC has advanced considerably. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112482DOI Listing

Application of purple phototrophic bacteria in a biofilm photobioreactor for single cell protein production: Biofilm vs suspended growth.

Water Res 2020 May 18;181:115909. Epub 2020 May 18.

Advanced Water Management Centre, The University of Queensland, Gehrmann Building, Brisbane, Queensland, 4072, Australia.

Single cell protein (SCP), has been proposed as alternative to effectively upgrade and recycle organics and nutrients from wastewater. Biomass recovery is a critical issue, and recovery as a biofilm is effective in comparison with sedimentation of suspended biomass. This study aims to determine the applicability of purple phototrophic bacteria (PPB) biofilm on infra-red irradiated, submerged surfaces for the treatment of pre-settled red meat processing wastewater, and SCP generation. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115909DOI Listing

Skin lesion segmentation via generative adversarial networks with dual discriminators.

Med Image Anal 2020 May 23;64:101716. Epub 2020 May 23.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518000, Shenzhen, China. Electronic address:

Skin lesion segmentation from dermoscopy images is a fundamental yet challenging task in the computer-aided skin diagnosis system due to the large variations in terms of their views and scales of lesion areas. We propose a novel and effective generative adversarial network (GAN) to meet these challenges. Specifically, this network architecture integrates two modules: a skip connection and dense convolution U-Net (UNet-SCDC) based segmentation module and a dual discrimination (DD) module. Read More

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http://dx.doi.org/10.1016/j.media.2020.101716DOI Listing

Nuclear NADPH Oxidase-4 Associated With Disease Progression In Renal Cell Carcinoma.

Transl Res 2020 May 31. Epub 2020 May 31.

Department of Urology, University of Texas Health, San Antonio, TX.

Nuclear NADPH oxidase-4 (Nox4) is a key component of metabolic reprogramming and is often overexpressed in renal cell carcinoma (RCC). However, its prognostic role in RCC remains unclear. Here we examined the significance of nuclear Nox4 on disease progression and development of drug resistance in advanced RCC. Read More

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http://dx.doi.org/10.1016/j.trsl.2020.05.009DOI Listing

Does COVID-19 infection impact on the trend of seasonal influenza infection? 11 countries and regions, from 2014 to 2020.

Int J Infect Dis 2020 May 31. Epub 2020 May 31.

Department of Healthcare Epidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan. Electronic address:

Objectives: Infection due to the 2019 novel coronavirus disease (COVID-19) is widespread dramatically around the world. This COVID-19 pandemic could increase public concern to prevent infectious disease. The present study aimed to assess the relationship between the COVID-19 epidemic and decreasing another infectious disease. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.088DOI Listing

Synthetic biology for protein-based materials.

Curr Opin Biotechnol 2020 May 31;65:197-204. Epub 2020 May 31.

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, People's Republic of China. Electronic address:

Recombinant protein polymers that mimic the structures and functions of natural proteins and those tailor-designed with new properties provide a family of uniquely tunable and functional materials. However, the diversity of genetically engineered protein polymers is still limited. As a powerful engine for the creation of new biological devices and systems, synthetic biology is promising to tackle the challenges that exist in conventional studies on protein polymers. Read More

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http://dx.doi.org/10.1016/j.copbio.2020.04.004DOI Listing

Functional connectivity of EEG is subject-specific, associated with phenotype, and different from fMRI.

Neuroimage 2020 May 31:117001. Epub 2020 May 31.

Department of Biomedical Engineering, The City College of New York, New York, NY, USA. Electronic address:

A variety of psychiatric, behavioral and cognitive phenotypes have been linked to brain ''functional connectivity'' -- the pattern of correlation observed between different brain regions. Most commonly assessed using functional magnetic resonance imaging (fMRI), here, we investigate the connectivity-phenotype associations with functional connectivity measured with electroencephalography (EEG), using phase-coupling. We analyzed data from the publicly available Healthy Brain Network Biobank. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117001DOI Listing

Treating COVID-19 with colchicine in community healthcare setting.

Clin Immunol 2020 May 31:108490. Epub 2020 May 31.

Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1016/j.clim.2020.108490DOI Listing

Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics.

Biochim Biophys Acta Rev Cancer 2020 May 31:188381. Epub 2020 May 31.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA. Electronic address:

The United State Food and Drug Administration has permitted number of therapeutic agents for cancer treatment. Most of them are expensive and have some degree of systemic toxicity which makes overbearing in clinical settings. Although advanced research continuously applied in cancer therapeutics, but drug resistance, metastasis, and recurrence remain unanswerable These accounts to an urgent clinical need to discover natural compounds with precisely safe and highly efficient for the cancer prevention and cancer therapy. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188381DOI Listing

Chest compressions induce errors in end-tidal carbon dioxide measurement.

Resuscitation 2020 May 31. Epub 2020 May 31.

University of the Basque Country, UPV/EHU, Bilbao, Bizkaia, Spain.

Background: Real-time measurement of end-tidal carbon dioxide (ETCO) is used as a non-invasive estimate of cardiac output and perfusion during cardiopulmonary resuscitation (CPR). However, capnograms are often distorted by chest compressions (CCs) and this may affect ETCO measurement. The aim of the study was to quantify the effect of CC-artefact on the accuracy of ETCO measurements obtained during out-of-hospital manual CPR. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2020.05.029DOI Listing

TMEM16A-inhibitor loaded pH-responsive nanoparticles: a novel dual-targeting antitumor therapy for lung adenocarcinoma.

Biochem Pharmacol 2020 May 31:114062. Epub 2020 May 31.

State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin 300130, China; Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin 300401, China. Electronic address:

To overcome the adverse effects of conventional chemotherapy for cancers, various nanoparticles based drug delivery systems have been developed. However, nanoparticles delivering drugs directly to kill tumor cells still faced with challenges, because tumors possessed adopt complex mechanism to resist damages, which compromised the therapeutic efficacy. TMEM16A/CaCCs (Calcium activates chloride channels) has been identified to be overexpressed in lung adenocarcinoma which can serve as a novel tumor specific drug target in our previous work. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114062DOI Listing

Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response.

Cell Rep 2020 Jun;31(9):107723

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:

The advent of base editors (BEs) holds great potential for correcting pathogenic-related point mutations to treat relevant diseases. However, Cas9 nickase (nCas9)-derived BEs lead to DNA double-strand breaks, which can trigger unwanted DNA damage response (DDR). Here, we show that the original version of catalytically dead Cas12a (dCas12a)-conjugated BEs induce a basal level of DNA breaks and minimally activate DDR proteins, including H2AX, ATM, ATR, and p53. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107723DOI Listing

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.

Cell 2020 May 28. Epub 2020 May 28.

Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China. Electronic address:

Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a training cohort of 18 non-severe and 13 severe patients. Read More

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http://dx.doi.org/10.1016/j.cell.2020.05.032DOI Listing

The 'Australia Model': how industry and government collaboration is showing us how MedTech can lead the way to a world class advanced manufacturing capability.

Authors:
Ian Burgess

Aust Health Rev 2020 Jun;44(3):336

Medical Technology Association of Australia, Level 12, 54 Miller Street, North Sydney, NSW 2060, Australia. Email:

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http://dx.doi.org/10.1071/AHv44n3_ED2DOI Listing

Ribociclib plus Fulvestrant in Advanced Breast Cancer. Reply.

N Engl J Med 2020 06;382(23):e85

University of Liege, Liege, Belgium.

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http://dx.doi.org/10.1056/NEJMc2004229DOI Listing

Ribociclib plus Fulvestrant in Advanced Breast Cancer.

Authors:
Elif Hindié

N Engl J Med 2020 06;382(23):e85

Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France

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http://dx.doi.org/10.1056/NEJMc2004229DOI Listing

Killing of Bacterial Spores by Dodecylamine and its Effects on Spore Inner membrane Properties.

J Appl Microbiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, 06030-3305, USA.

Aims: Determine effects of Ca-dipicolinic acid (CaDPA), cortex-lytic enzymes (CLEs), the inner membrane (IM) CaDPA channel and coat on spore killing by dodecylamine.

Methods And Results: Bacillus subtilis spores, wild-type, CaDPA-less due to absence of DPA synthase or the IM CaDPA channel, or lacking CLEs, were dodecylamine-treated and spore viability and vital staining determined. Dodecylamine killed intact wild type and CaDPA-less B. Read More

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http://dx.doi.org/10.1111/jam.14732DOI Listing

A developmental staging system and musculoskeletal development sequence of the Common Musk turtle (Sternotherus odoratus).

Dev Dyn 2020 Jun 3. Epub 2020 Jun 3.

Department of Earth and Planetary Science , Peabody Museum of Natural History, Yale University.

Background: The extremely derived body plan of turtles has sparked a great interest in studying their developmental biology. Here, we describe the embryonic development of the Stinkpot, or Common musk turtle (Sternotherus odoratus), a small aquatic turtle from the family Kinosternidae.

Results: We identify 20 distinct developmental stages, some comparable to stages described by previous studies on other turtles and some in between these, improving the resolution of the generalities of turtle development. Read More

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http://dx.doi.org/10.1002/dvdy.210DOI Listing

Pericardial fat volume and coronary atherosclerotic markers among body mass index groups.

Clin Cardiol 2020 Jun 3. Epub 2020 Jun 3.

Radiology Department, Medicine College, University Of Kufa, Najaf, Iraq.

Background: Increased pericardial fat volume (PFV) is associated with coronary atherosclerosis burden independent of body mass index (BMI) in many clinical studies. However, the association of PFV with markers of coronary atherosclerosis has not yet been assessed by dividing the patients according to BMI categories.

Hypothesis: To assess the association of PFV measured by multi-detector CT (MDCT) angiography with coronary atherosclerotic markers (coronary artery calcium score [CAC], plaque type, and luminal stenosis) among BMI categories. Read More

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http://dx.doi.org/10.1002/clc.23396DOI Listing

Enantiomeric discrimination through tip-enhanced Raman scattering using a chemically modified silver tip with an asymmetric atomic arrangement.

Angew Chem Int Ed Engl 2020 Jun 3. Epub 2020 Jun 3.

Kwansei Gakuin University, School of Science and Technology, 2-1 Gakuen, 669-1337, Sanda, Hyogo, JAPAN.

Enantiomeric discrimination is achieved by tip-enhanced Raman scattering (TERS) using a silver tip chemically modified by an achiral para -mercaptopyridine ( p MPY) probe molecule. Differences in the relative intensities of the p MPY spectra were monitored for three pairs of enantiomers containing hydroxyl (-OH) and/or amino (-NH 2 ) groups. The N: or N + -H functionality of the p MPY-modified tip participates in hydrogen bond interactions with a particular molecular orientation of each chiral isomer. Read More

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http://dx.doi.org/10.1002/anie.202005446DOI Listing

Whole-heart, ungated, free-breathing, cardiac-phase-resolved myocardial perfusion MRI by using Continuous Radial Interleaved simultaneous Multi-slice acquisitions at sPoiled steady-state (CRIMP).

Magn Reson Med 2020 Jun 3. Epub 2020 Jun 3.

Utah Center for Advanced Imaging Research (UCAIR), Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.

Purpose: To develop a whole-heart, free-breathing, non-electrocardiograph (ECG)-gated, cardiac-phase-resolved myocardial perfusion MRI framework (CRIMP; Continuous Radial Interleaved simultaneous Multi-slice acquisitions at sPoiled steady-state) and test its quantification feasibility.

Methods: CRIMP used interleaved radial simultaneous multi-slice (SMS) slice groups to cover the whole heart in 9 or 12 short-axis slices. The sequence continuously acquired data without magnetization preparation, ECG gating or breath-holding, and captured multiple cardiac phases. Read More

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http://dx.doi.org/10.1002/mrm.28337DOI Listing

Short communication: Embolization of tumor cells is rare in patients with systemic cancer and cerebral large vessel occlusion.

Eur J Neurol 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology and Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, CH-8091, Zurich, Switzerland.

Background: Stroke is a dreaded complication in patients with cancer. Besides paraneoplastic coagulopathy, chemotherapy, radiotherapy and tumor-directed invasive procedures, circulating cancer cells may contribute to thrombus formation and embolic stroke. However, the incidence of tumor cells within blood clots of cancer patients with stroke is unknown and the role of circulating tumor cells in the formation of cerebrovascular thrombi remains unclear. Read More

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http://dx.doi.org/10.1111/ene.14372DOI Listing

Author response to: Beyond T, N and M: can lateral lymph node dissection treat tumour deposits in advanced low rectal carcinoma?

Br J Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Colorectal Surgery, National Cancer Centre Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1002/bjs.11743DOI Listing

Laparoscopic sentinel node navigation surgery versus laparoscopic gastrectomy with lymph node dissection for early gastric cancer: short-term outcomes of a multicentre randomized controlled trial (SENORITA).

Br J Surg 2020 Jun 3. Epub 2020 Jun 3.

Centre for Gastric Cancer.

Background: Sentinel node navigation surgery reduces the extent of gastric and lymph node dissection, and may improve quality of life. The benefit and harm of laparoscopic sentinel node navigation surgery (LSNNS) for early gastric cancer is unknown. The SENORITA (SEntinel Node ORIented Tailored Approach) trial investigated the pathological and surgical outcomes of LSNNS compared with laparoscopic standard gastrectomy (LSG) with lymph node dissection. Read More

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http://dx.doi.org/10.1002/bjs.11655DOI Listing

Patient-reported outcomes as a prognostic marker of survival in patients with advanced non-small cell lung cancer treated with immunotherapy: PROs as a prognostic marker for immunotherapies.

Int J Cancer 2020 Jun 3. Epub 2020 Jun 3.

College of Medicine and Public Health, Flinders University, Adelaide, Australia.

There's been minimal research on the prognostic value of patient-reported outcomes (PROs) for immune checkpoint inhibitors (ICIs). The relative performance of PROs compared to established markers such as Eastern Cooperative Oncology Group Performance Status (ECOG-PS) and the Lung Immune Prognostic Index (LIPI) is unknown. In this study, data from the advanced non-small cell lung cancer (NSCLC) single-arm atezolizumab trials BIRCH, FIR, and randomized-trials OAK, POPLAR (atezolizumab vs docetaxel) were pooled. Read More

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http://dx.doi.org/10.1002/ijc.33133DOI Listing

Beyond T, N and M: can lateral lymph node dissection treat tumour deposits in advanced low rectal carcinoma?

Authors:
N Peparini

Br J Surg 2020 Jun 3. Epub 2020 Jun 3.

Azienda Sanitaria Locale Roma 6, Ciampino, Rome, Italy.

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http://dx.doi.org/10.1002/bjs.11742DOI Listing

Deploying Big Data to Crack the Genotype to Phenotype Code.

Integr Comp Biol 2020 Jun 3. Epub 2020 Jun 3.

Department of Ecology, Evolution and Organismal Biology, Kennesaw State University, Kennesaw, GA.

Mechanistically connecting genotypes to phenotypes is a longstanding and central mission of biology. Deciphering these connections will unite questions and datasets across all scales from molecules to ecosystems. Although high-throughput sequencing has provided a rich platform on which to launch this effort, tools for deciphering mechanisms further along the genome to phenome pipeline remain limited. Read More

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http://dx.doi.org/10.1093/icb/icaa055DOI Listing
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