1,664 results match your criteria Advanced Science[Journal]


Highly Transparent and Flexible Iontronic Pressure Sensors Based on an Opaque to Transparent Transition.

Adv Sci (Weinh) 2020 May 12;7(10):2000348. Epub 2020 Mar 12.

Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen 518055 China.

Human-computer interfaces, smart glasses, touch screens, and some electronic skins require highly transparent and flexible pressure-sensing elements. Flexible pressure sensors often apply a microstructured or porous active material to improve their sensitivity and response speed. However, the microstructures or small pores will result in high haze and low transparency of the device, and thus it is challenging to balance the sensitivity and transparency simultaneously in flexible pressure sensors or electronic skins. Read More

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http://dx.doi.org/10.1002/advs.202000348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237840PMC

Core-Shell Structured NiFeSn@NiFe (Oxy)Hydroxide Nanospheres from an Electrochemical Strategy for Electrocatalytic Oxygen Evolution Reaction.

Adv Sci (Weinh) 2020 May 28;7(10):1903777. Epub 2020 Mar 28.

College of Materials Science and Engineering Shenzhen University Shenzhen 518060 China.

Efficient electrocatalysts for the oxygen evolution reaction (OER) are highly desirable because of the intrinsically sluggish kinetics of OER. Herein, core-shell structured nanospheres of NiFe Sn@NiFe (oxy)hydroxide (denoted as NiFe Sn-A) are prepared as active OER catalysts by a facile electrochemical strategy, which includes electrodeposition of NiFe Sn alloy nanospheres on carbon cloth (CC) and following anodization. The alloy core of NiFe Sn could promote charge transfer, and the amorphous shell of NiFe (oxy)hydroxide is defect-rich and nanoporous due to the selective electrochemical etching of Sn in alkaline medium. Read More

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http://dx.doi.org/10.1002/advs.201903777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237859PMC

A Biomimetic Plasmonic Nanoreactor for Reliable Metabolite Detection.

Adv Sci (Weinh) 2020 May 11;7(10):1903730. Epub 2020 Mar 11.

Department of Neurosurgery Shanghai Children's Hospital Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200062 China.

Reliable monitoring of metabolites in biofluids is critical for diagnosis, treatment, and long-term management of various diseases. Although widely used, existing enzymatic metabolite assays face challenges in clinical practice primarily due to the susceptibility of enzyme activity to external conditions and the low sensitivity of sensing strategies. Inspired by the micro/nanoscale confined catalytic environment in living cells, the coencapsulation of oxidoreductase and metal nanoparticles within the nanopores of macroporous silica foams to fabricate all-in-one bio-nanoreactors is reported herein for use in surface-enhanced Raman scattering (SERS)-based metabolic assays. Read More

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http://dx.doi.org/10.1002/advs.201903730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237842PMC

Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome-Wide Association Study in Multiple Cohorts.

Adv Sci (Weinh) 2020 May 20;7(10):1903727. Epub 2020 Mar 20.

Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060 P. R. China.

Germline polymorphisms are linked with differential survival outcomes in cancers but are not well studied in nasopharyngeal carcinoma (NPC). Here, a two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Read More

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http://dx.doi.org/10.1002/advs.201903727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237860PMC

Highly Reproducible, Bio-Based Slab Photonic Crystals Grown by Diatoms.

Adv Sci (Weinh) 2020 May 21;7(10):1903726. Epub 2020 Mar 21.

International Iberian Nanotechnology Laboratory Braga 4715-330 Portugal.

Slab photonic crystals (PhCs) are photonic structures used in many modern optical technologies. Fabrication of these components is costly and usually involves eco-unfriendly methods, requiring modern nanofabrication techniques and cleanroom facilities. This work describes that diatom microalgae evolved elaborate and highly reproducible slab PhCs in the girdle, a part of their silicon dioxide exoskeletons. Read More

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http://dx.doi.org/10.1002/advs.201903726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237861PMC

Efficient Energy Conversion and Storage Based on Robust Fluoride-Free Self-Assembled 1D Niobium Carbide in 3D Nanowire Network.

Adv Sci (Weinh) 2020 May 6;7(10):1903680. Epub 2020 Apr 6.

Department of Applied Physics The Hong Kong Polytechnic University Hong Kong P. R. China.

Owing to their high robustness and conductivity, 2D transition metal carbides and nitrides known as MXenes are considered as a promising material class for electrochemical catalysis, energy conversion, and storage applications. Nevertheless, conventional hazardous fluoride-based synthesis routes and the intense intralayer bonding restrict the development of MXenes. Herein, a fluoride-free, facile, and rapid method for synthesizing self-assembled 1D architecture from an MXene-based compound is reported. Read More

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http://dx.doi.org/10.1002/advs.201903680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237850PMC

Hepatocyte TMEM16A Deletion Retards NAFLD Progression by Ameliorating Hepatic Glucose Metabolic Disorder.

Adv Sci (Weinh) 2020 May 20;7(10):1903657. Epub 2020 Mar 20.

Department of Pharmacology Cardiac and Cerebral Vascular Research Center Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 China.

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease, and the mechanisms underpinning its pathogenesis have not been completely established. Transmembrane member 16A (TMEM16A), a component of the Ca-activated chloride channel (CaCC), has recently been implicated in metabolic events. Herein, TMEM16A is shown to be responsible for CaCC activation in hepatocytes and is increased in liver tissues of mice and patients with NAFLD. Read More

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http://dx.doi.org/10.1002/advs.201903657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237841PMC

Imaging Chemical Kinetics of Radical Polymerization with an Ultrafast Coherent Raman Microscope.

Adv Sci (Weinh) 2020 May 9;7(10):1903644. Epub 2020 Mar 9.

Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan Hubei 430074 China.

Numerous mechanisms have been proposed for polymerization to provide qualitative and quantitative prediction of how monomers spatially and temporally arrange into the polymeric chains. However, less is known about this process at the molecular level because the ultrafast chemical reaction is inaccessible for any form of microscope so far. Here, to address this unmet challenge, a stimulated Raman scattering microscope based on collinear multiple beams (COMB-SRS) is demonstrated, which allows label-free molecular imaging of polymer synthesis in action at speed of 2000 frames per second. Read More

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http://dx.doi.org/10.1002/advs.201903644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237838PMC

Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.

Adv Sci (Weinh) 2020 May 6;7(10):1903585. Epub 2020 Apr 6.

State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China.

Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (I) are used in situ to construct active sites in a nanocatalyst (TiO) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). Read More

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http://dx.doi.org/10.1002/advs.201903585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237849PMC

Strategies for Improving the Stability of Tin-Based Perovskite (ASnX) Solar Cells.

Adv Sci (Weinh) 2020 May 20;7(10):1903540. Epub 2020 Feb 20.

School of Physical Science and Technology & Key Laboratory for Magnetism and Magnetic Materials of MoE & Key Laboratory of Special Function Materials and Structure Design MoE Lanzhou University Lanzhou 730000 China.

Although lead-based perovskite solar cells (PSCs) are highly efficient, the toxicity of lead (Pb) limits its large-scale commercialization. As such, there is an urgent need to find alternatives. Many studies have examined tin-based PSCs. Read More

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http://dx.doi.org/10.1002/advs.201903540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237862PMC

Medical Gas Plasma Jet Technology Targets Murine Melanoma in an Immunogenic Fashion.

Adv Sci (Weinh) 2020 May 30;7(10):1903438. Epub 2020 Mar 30.

ZIK plasmatis Leibniz Institute for Plasma Science and Technology (INP Greifswald) Felix-Hausdorff-Str. 3 Greifswald 17489 Germany.

Medical technologies from physics are imperative in the diagnosis and therapy of many types of diseases. In 2013, a novel cold physical plasma treatment concept was accredited for clinical therapy. This gas plasma jet technology generates large amounts of different reactive oxygen and nitrogen species (ROS). Read More

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http://dx.doi.org/10.1002/advs.201903438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237847PMC

Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9-Mediated Knockin of Retinoschisin 1 Gene-A Potential Nonviral Therapeutic Solution for X-Linked Juvenile Retinoschisis.

Adv Sci (Weinh) 2020 May 16;7(10):1903432. Epub 2020 Apr 16.

Division of Basic Research Department of Medical Research and Department of Ophthalmology Taipei Veterans General Hospital Taipei 112 Taiwan.

The homology-independent targeted integration (HITI) strategy enables effective CRISPR/Cas9-mediated knockin of therapeutic genes in nondividing cells in vivo, promising general therapeutic solutions for treating genetic diseases like X-linked juvenile retinoschisis. Herein, supramolecular nanoparticle (SMNP) vectors are used for codelivery of two DNA plasmids-CRISPR-Cas9 genome-editing system and a therapeutic gene, Retinoschisin 1 (RS1)-enabling clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR/Cas9) knockin of the RS1 gene with HITI. Through small-scale combinatorial screenings, two SMNP vectors, with Cas9 and single guide RNA (sgRNA)-plasmid in one and Donor-RS1 and green fluorescent protein (GFP)-plasmid in the other, with optimal delivery performances are identified. Read More

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http://dx.doi.org/10.1002/advs.201903432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237855PMC

Halide Perovskites: Thermal Transport and Prospects for Thermoelectricity.

Adv Sci (Weinh) 2020 May 16;7(10):1903389. Epub 2020 Apr 16.

KAUST Solar Center Physical Science and Engineering Division King Abdullah University of Science and Technology Thuwal 23955-6900 Saudi Arabia.

The recent re-emergence of halide perovskites has received escalating interest for optoelectronic applications. In addition to photovoltaics, the multifunctional nature of halide perovskites has led to diverse applications. The ultralow thermal conductivity coupled with decent mobility and charge carrier tunability led to the prediction of halide perovskites as a possible contender for future thermoelectrics. Read More

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http://dx.doi.org/10.1002/advs.201903389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237854PMC

ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia.

Adv Sci (Weinh) 2020 May 20;7(10):1903330. Epub 2020 Mar 20.

Department of Neurosurgery Shanghai Jiaotong University Affiliated Sixth People's Hospital Shanghai 200233 China.

Vascular dementia (VD) is one of the most common types of dementia, however, the intrinsic mechanism is unclear and there is still lack of effective medications. In this study, the VD rats exhibit a progressive cognitive impairment, as well as a time-related increasing in hippocampal neural stem cells (H-NSCs) senescence, lost and neurogenesis decline. Then, embryonic stem cell-derived small extracellular vesicles (ESC-sEVs) are intravenously injected into VD rats. Read More

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http://dx.doi.org/10.1002/advs.201903330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237844PMC

Solvent Engineering Using a Volatile Solid for Highly Efficient and Stable Perovskite Solar Cells.

Adv Sci (Weinh) 2020 May 10;7(10):1903250. Epub 2020 Mar 10.

Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Laboratory for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China.

A strategy for efficaciously regulating perovskite crystallinity is proposed by using a volatile solid glycolic acid (HOCHCOOH, GA) in an FAMAPbI (FA: HC(NH); MA: CHNH) perovskite precursor solution that is different from the common additive approach. Accompanied with the first dimethyl sulfoxide sublimation process, the subsequent sublimation of GA before 150 °C in the FAMAPbI perovskite film can artfully regulate the perovskite crystallinity without any residual after annealing. The improved film formation upon GA modification induced by the strong interaction between GA and Pb delivers a champion power conversion efficiency (PCE) as high as 21. Read More

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http://dx.doi.org/10.1002/advs.201903250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237837PMC

Small Protein Hidden in lncRNA Promotes "Cancerous" RNA Splicing and Tumorigenesis.

Adv Sci (Weinh) 2020 May 11;7(10):1903233. Epub 2020 Mar 11.

Biomedicine Research Center The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150 China.

Conventional therapies for late-stage colorectal cancer (CRC) have limited effects because of chemoresistance, recurrence, and metastasis. The "hidden" proteins/peptides encoded by long noncoding RNAs (lncRNAs) may be a novel resource bank for therapeutic options for patients with cancer. Here, lncRNA is discovered to encode a small 130-amino acid protein that interacts with several splicing regulators, such as serine- and arginine-rich splicing factor 3 (SRSF3), to regulate mRNA splicing, and the protein thus is named "Splicing Regulatory Small Protein" (SRSP). Read More

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http://dx.doi.org/10.1002/advs.201903233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237858PMC

Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer.

Adv Sci (Weinh) 2020 May 20;7(10):1903164. Epub 2020 Feb 20.

Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China.

Growing experience with engineered chimeric antigen receptor (CAR)-T cells has revealed some of the challenges associated with developing patient-specific therapy. The promising clinical results obtained with CAR-T therapy nevertheless demonstrate the urgency of advancements to promote and expand its uses. There is indeed a need to devise novel methods to generate potent CARs, and to confer them and track their anti-tumor efficacy in CAR-T therapy. Read More

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http://dx.doi.org/10.1002/advs.201903164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237845PMC

Simultaneous Full-Color Printing and Holography Enabled by Centimeter-Scale Plasmonic Metasurfaces.

Adv Sci (Weinh) 2020 May 16;7(10):1903156. Epub 2020 Mar 16.

State Key Laboratory of Optical Technologies on Nano-Fabrication and Micro-Engineering Institute of Optics and Electronics Chinese Academy of Sciences Chengdu 610209 China.

Optical metasurfaces enable novel ways to locally manipulate light's amplitude, phase, and polarization, underpinning a newly viable technology for applications, such as high-density optical storage, holography, and displays. Here, a high-security-level platform enabled by centimeter-scale plasmonic metasurfaces with full-color, high-purity, and enhanced-information-capacity properties is proposed. Multiple types of independent information can be embedded into a single metamark using full parameters of light, including amplitude, phase, and polarization. Read More

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http://dx.doi.org/10.1002/advs.201903156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237853PMC

Optimized Metal Chalcogenides for Boosting Water Splitting.

Adv Sci (Weinh) 2020 May 6;7(10):1903070. Epub 2020 Apr 6.

State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China.

Electrocatalytic water splitting (2HO → 2H + O) is a very promising avenue to effectively and environmentally friendly produce highly pure hydrogen (H) and oxygen (O) at a large scale. Different materials have been developed to enhance the efficiency for water splitting. Among them, chalcogenides with unique atomic arrangement and high electronic transport show interesting catalytic properties in various electrochemical reactions, such as the hydrogen evolution reaction, oxygen evolution reaction, and overall water splitting, while the control of their morphology and structure is of vital importance to their catalytic performance. Read More

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http://dx.doi.org/10.1002/advs.201903070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237848PMC

Antimicrobial Metal Nanomaterials: From Passive to Stimuli-Activated Applications.

Adv Sci (Weinh) 2020 May 6;7(10):1902913. Epub 2020 Apr 6.

School of Science College of Science Engineering and Health RMIT University Melbourne VIC 3001 Australia.

The development of antimicrobial drug resistance among pathogenic bacteria and fungi is one of the most significant health issues of the 21st century. Recently, advances in nanotechnology have led to the development of nanomaterials, particularly metals that exhibit antimicrobial properties. These metal nanomaterials have emerged as promising alternatives to traditional antimicrobial therapies. Read More

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http://dx.doi.org/10.1002/advs.201902913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237851PMC

Anisotropic Collective Charge Excitations in Quasimetallic 2D Transition-Metal Dichalcogenides.

Adv Sci (Weinh) 2020 May 16;7(10):1902726. Epub 2020 Apr 16.

Department of Physics Faculty of Science National University of Singapore S12 Science Drive 3 Singapore 117551 Singapore.

The quasimetallic 1T' phase 2D transition-metal dichalcogenides (TMDs) consist of 1D zigzag metal chains stacked periodically along a single axis. This gives rise to its prominent physical properties which promises the onset of novel physical phenomena and applications. Here, the in-plane electronic correlations are explored, and new mid-infrared plasmon excitations in 1T' phase monolayer WSe and MoS are observed using optical spectroscopies. Read More

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http://dx.doi.org/10.1002/advs.201902726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237846PMC

Novel All-Nitrogen Molecular Crystals of Aromatic N.

Adv Sci (Weinh) 2020 May 30;7(10):1902320. Epub 2020 Mar 30.

State Key Laboratory of Superhard Materials Jilin University Changchun 130012 China.

Nitrogen has unique bonding ability to form single, double, and triple bonds, similar to that of carbon. However, a molecular crystal formed by an aromatic polynitrogen similar to a carbon system has not been found yet. Herein, a new form of stable all-nitrogen molecular crystals consisting of only bispentazole N molecules with exceedingly high energy density is predicted. Read More

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http://dx.doi.org/10.1002/advs.201902320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237857PMC

Autogenous Production and Stabilization of Highly Loaded Sub-Nanometric Particles within Multishell Hollow Metal-Organic Frameworks and Their Utilization for High Performance in Li-O Batteries.

Adv Sci (Weinh) 2020 May 16;7(9):2000283. Epub 2020 Mar 16.

Department of Materials Science and Engineering and NanoCentury KAIST Institute Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro, Yuseong-gu Daejeon 34141 Republic of Korea.

Sub-nanometric particles (SNPs) of atomic cluster sizes have shown great promise in many fields such as full atom-to-atom utilization, but their precise production and stabilization at high mass loadings remain a great challenge. As a solution to overcome this challenge, a strategy allowing synthesis and preservation of SNPs at high mass loadings within multishell hollow metal-organic frameworks (MOFs) is demonstrated. First, alternating water-decomposable and water-stable MOFs are stacked in succession to build multilayer MOFs. Read More

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http://dx.doi.org/10.1002/advs.202000283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201254PMC

Dual-Enhanced Doping in ReSe for Efficiently Photoenhanced Hydrogen Evolution Reaction.

Adv Sci (Weinh) 2020 May 16;7(9):2000216. Epub 2020 Mar 16.

National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of Technology Harbin 150001 China.

Rhenium dichalcogenides (ReX, X = S or Se) are catalysts that have great promise for the photoenhanced hydrogen evolution reaction (PE-HER) because of their unique physiochemical properties. However, the catalytic performance is still restricted by their low concentration of electrocatalytic activity sites and poor injection of hot electrons. Herein, dual-enhancement in ReSe nanosheets (NSs) with high concentration of active sites and efficient use of hot electrons is simultaneously achieved with moderate Mo doping. Read More

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http://dx.doi.org/10.1002/advs.202000216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201260PMC

Conductive Metal-Organic Frameworks with Extra Metallic Sites as an Efficient Electrocatalyst for the Hydrogen Evolution Reaction.

Adv Sci (Weinh) 2020 May 16;7(9):2000012. Epub 2020 Mar 16.

Key Laboratory of Macromolecular Science of Shaanxi Province Shaanxi Key Laboratory for Advanced Energy Devices School of Materials Science and Engineering Shaanxi Normal University Xi'an 710062 P. R. China.

The 2D conductive metal-organic frameworks (MOFs) are expected to be an ideal electrocatalyst due to their high utilization of metal atoms. Exploring a new conjugated ligand with extra active metallic center can further boost the structural advantages of conductive MOFs. In this work, hexaiminohexaazatrinaphthalene (HAHATN) is employed as a conjugated ligand to construct bimetallic sited conductive MOFs (M2(M1∙HAHATN)) with an extra M-N moiety. Read More

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http://dx.doi.org/10.1002/advs.202000012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201256PMC

Bromination: An Alternative Strategy for Non-Fullerene Small Molecule Acceptors.

Adv Sci (Weinh) 2020 May 28;7(9):1903784. Epub 2020 Feb 28.

Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and Technology Shenzhen 518055 China.

The concept of bromination for organic solar cells has received little attention. However, the electron withdrawing ability and noncovalent interactions of bromine are similar to those of fluorine and chlorine atoms. A tetra-brominated non-fullerene acceptor, designated as BTIC-4Br, has been recently developed by introducing bromine atoms onto the end-capping group of 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene) malononitrile and displayed a high power conversion efficiency (PCE) of 12%. Read More

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http://dx.doi.org/10.1002/advs.201903784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201261PMC

Next-Generation Cancer-Specific Hybrid Theranostic Nanomaterials: MAGE-A3 NIR Persistent Luminescence Nanoparticles Conjugated to Afatinib for In Situ Suppression of Lung Adenocarcinoma Growth and Metastasis.

Adv Sci (Weinh) 2020 May 14;7(9):1903741. Epub 2020 Mar 14.

Genomics Research Center Academia Sinica Taipei 115 Taiwan.

The rate of lung cancer has gradually increased in recent years, with an average annual increase of 15%. Afatinib (AFT) plays a key role in preventing non-small cell lung carcinoma (NSCLC) growth and spread. To increase the efficiency of drug loading and NSCLC cell tracking, near infrared-persistent luminescence nanomaterials (NIR PLNs), a silica shell-assisted synthetic route for mono-dispersal, are developed and used in the nanovehicle. Read More

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http://dx.doi.org/10.1002/advs.201903741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201263PMC

Designer Self-Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer.

Adv Sci (Weinh) 2020 May 20;7(9):1903718. Epub 2020 Mar 20.

Institute for Nanobiomedical Technology and Membrane Biology West China Hospital Sichuan University Chengdu Sichuan 610041 P. R. China.

Designer self-assembling peptides form the entangled nanofiber networks in hydrogels by ionic-complementary self-assembly. This type of hydrogel has realistic biological and physiochemical properties to serve as biomimetic extracellular matrix (ECM) for biomedical applications. The advantages and benefits are distinct from natural hydrogels and other synthetic or semisynthetic hydrogels. Read More

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http://dx.doi.org/10.1002/advs.201903718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201262PMC

A Biomimetic 3D-Self-Forming Approach for Microvascular Scaffolds.

Adv Sci (Weinh) 2020 May 1;7(9):1903553. Epub 2020 Mar 1.

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. China.

The development of science and technology often drew lessons from natural phenomena. Herein, inspired by drying-driven curling of apple peels, hydrogel-based micro-scaled hollow tubules (MHTs) are proposed for biomimicking microvessels, which promote microcirculation and improve the survival of random skin flaps. MHTs with various pipeline structures are fabricated using hydrogel in corresponding shapes, such as Y-branches, anastomosis rings, and triangle loops. Read More

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http://dx.doi.org/10.1002/advs.201903553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201264PMC

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression.

Adv Sci (Weinh) 2020 May 12;7(9):1903483. Epub 2020 Mar 12.

East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai 200241 P. R. China.

Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis-associated enzymes are rarely understood. The lack of potent and selective antimetabolism drugs restrains further clinical investigations. Read More

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http://dx.doi.org/10.1002/advs.201903483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201266PMC

Structure Architecting for Salt-Rejecting Solar Interfacial Desalination to Achieve High-Performance Evaporation With In Situ Energy Generation.

Adv Sci (Weinh) 2020 May 31;7(9):1903478. Epub 2020 Mar 31.

Department of Materials Science and Engineering National University of Singapore 9 Engineering drive 1 Singapore 117574 Singapore.

The past few years have witnessed a rapid development of solar-driven interfacial evaporation, a promising technology for low-cost water desalination. As of today, solar-to-steam conversion efficiencies close to 100% or even beyond the limit are becoming increasingly achievable in virtue of unique photothermal materials and structures. Herein, the cutting-edge approaches are summarized, and their mechanisms for photothermal structure architecting are uncovered in order to achieve ultrahigh conversion efficiency. Read More

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http://dx.doi.org/10.1002/advs.201903478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201268PMC

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.

Adv Sci (Weinh) 2020 May 26;7(9):1903410. Epub 2020 Mar 26.

Institute of Cancer Xinqiao Hospital The Army Medical University Xinqiao Main Street Chongqing 400037 China.

The evolutionary dynamics of tumor-associated neoantigens carry information about drug sensitivity and resistance to the immune checkpoint blockade (ICB). However, the spectrum of somatic mutations is highly heterogeneous among patients, making it difficult to track neoantigens by circulating tumor DNA (ctDNA) sequencing using "one size fits all" commercial gene panels. Thus, individually customized panels (ICPs) are needed to track neoantigen evolution comprehensively during ICB treatment. Read More

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http://dx.doi.org/10.1002/advs.201903410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201246PMC

A Material Combination Concept to Realize 4D Printed Products with Newly Emerging Property/Functionality.

Adv Sci (Weinh) 2020 May 20;7(9):1903208. Epub 2020 Mar 20.

State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China.

4D printing is a newly emerging technique that shows the capability of additively manufacturing structures whose shape, property, or functionality can controllably vary with time under external stimuli. However, most of the existing 4D printed products only focus on the variation of physical geometries, regardless of controllable changes of their properties, as well as practical functionality. Here, a material combination concept is proposed to construct 4D printed devices whose property and functionality can controllably vary. Read More

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http://dx.doi.org/10.1002/advs.201903208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201257PMC

Semi-Flooded Sulfur Cathode with Ultralean Absorbed Electrolyte in Li-S Battery.

Adv Sci (Weinh) 2020 May 18;7(9):1903168. Epub 2020 Mar 18.

Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA.

Lean electrolyte (small E/S ratio) is urgently needed to achieve high practical energy densities in Li-S batteries, but there is a distinction between the cathode's absorbed electrolyte (AE) which is cathode-intrinsic and total added electrolyte (E) which depends on cell geometry. While total pore volume in sulfur cathodes affects AE/S and performance, it is shown here that pore morphology, size, connectivity, and fill factor all matter. Compared to conventional thermally dried sulfur cathodes that usually render "open lakes" and closed pores, a freeze-dried and compressed (FDS-C) sulfur cathode is developed with a canal-capillary pore structure, which exhibits high mean performance and greatly reduces cell-to-cell variation, even at high sulfur loading (14. Read More

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http://dx.doi.org/10.1002/advs.201903168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201250PMC

Ferromagnetic Order at Room Temperature in Monolayer WSe Semiconductor via Vanadium Dopant.

Adv Sci (Weinh) 2020 May 11;7(9):1903076. Epub 2020 Mar 11.

Center for Integrated Nanostructure Physics (CINAP) Institute for Basic Science (IBS) Suwon 16419 Republic of Korea.

Diluted magnetic semiconductors including Mn-doped GaAs are attractive for gate-controlled spintronics but Curie transition at room temperature with long-range ferromagnetic order is still debatable to date. Here, the room-temperature ferromagnetic domains with long-range order in semiconducting V-doped WSe monolayer synthesized by chemical vapor deposition are reported. Ferromagnetic order is manifested using magnetic force microscopy up to 360 K, while retaining high on/off current ratio of ≈10 at 0. Read More

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http://dx.doi.org/10.1002/advs.201903076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201245PMC

Ion Exchange/Insertion Reactions for Fabrication of Efficient Methylammonium Tin Iodide Perovskite Solar Cells.

Adv Sci (Weinh) 2020 May 14;7(9):1903047. Epub 2020 Mar 14.

Key Laboratory of Green Printing Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China.

The low toxicity, narrow bandgaps, and high charge-carrier mobilities make tin perovskites the most promising light absorbers for low-cost perovskite solar cells (PSCs). However, the development of the Sn-based PSCs is seriously hampered by the critical issues of poor stability and low power conversion efficiency (PCE) due to the facile oxidation of Sn to Sn and poor film formability of the perovskite films. Herein, a synthetic strategy is developed for the fabrication of methylammonium tin iodide (MASnI) film via ion exchange/insertion reactions between solid-state SnF and gaseous methylammonium iodide. Read More

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http://dx.doi.org/10.1002/advs.201903047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201265PMC

Advances in the Knowledge of the Molecular Biology of Glioblastoma and Its Impact in Patient Diagnosis, Stratification, and Treatment.

Adv Sci (Weinh) 2020 May 12;7(9):1902971. Epub 2020 Mar 12.

Department of Molecular Biology and Biochemistry Faculty of Sciences Campus de Teatinos s/n University of Málaga Málaga E-29071 Spain.

Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue and primarily occur in the brain. Low-grade tumors of World Health Organization (WHO) grade II tend to progress to high-grade gliomas of WHO grade III and, eventually, glioblastoma of WHO grade IV, which is the most common and deadly glioma, with a median survival of 12-15 months after final diagnosis. Read More

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http://dx.doi.org/10.1002/advs.201902971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201267PMC

Nanoparticle-Mediated Intracellular Protection of Natural Killer Cells Avoids Cryoinjury and Retains Potent Antitumor Functions.

Adv Sci (Weinh) 2020 May 13;7(9):1902938. Epub 2020 Mar 13.

Department of Industrial and Physical Pharmacy Purdue University West Lafayette IN 47907 USA.

The ability of natural killer (NK) cells to mediate potent antitumor immunity in clinical adoptive transfer settings relies, in large part, on their ability to retain cytotoxic function following cryopreservation. To avoid potential systemic toxicities associated with infusions of NK cells into patients in the presence of dimethylsulfoxide (DMSO), interest in alternative cryoprotective agents (CPAs) with improved safety profiles has grown. Despite the development of various sugars, amino acids, polyols, and polyampholytes as cryoprotectants, their ability to promote protection from intracellular cryodamage is limited because they mostly act outside of the cell. Read More

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http://dx.doi.org/10.1002/advs.201902938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201255PMC

Unveiling the Effects of Hydrolysis-Derived DMAI/DMAPbI Intermediate Compound on the Performance of CsPbI Solar Cells.

Adv Sci (Weinh) 2020 May 14;7(9):1902868. Epub 2020 Mar 14.

School of Physical Science and Technology & Key Laboratory for Magnetism and Magnetic Materials of MoE & Key Laboratory of Special Function Materials and Structure Design MoE & National & Local Joint Engineering Laboratory for Optical Conversion Materials and Technology Lanzhou University Lanzhou 730000 P. R. China.

Introducing hydroiodic acid (HI) as a hydrolysis-derived precursor of the intermediate compounds has become an increasingly important issue for fabricating high quality and stable CsPbI perovskite solar cells (PSCs). However, the materials composition of the intermediate compounds and their effects on the device performance remain unclear. Here, a series of high-quality intermediate compounds are prepared and it is shown that they consist of DMAI/DMAPbI . Read More

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http://dx.doi.org/10.1002/advs.201902868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201252PMC

Overcoming Multidrug-Resistant MRSA Using Conventional Aminoglycoside Antibiotics.

Adv Sci (Weinh) 2020 May 14;7(9):1902070. Epub 2020 Mar 14.

Hubei Key Laboratory of Polymer Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science & Engineering Hubei University Wuhan 430062 China.

Global multidrug-resistant (MDR) bacteria are spreading rapidly and causing a great threat to human health due to the abuse of antibiotics. Determining how to resensitize MDR bacteria to conventional inefficient antibiotics is of extreme urgency. Here, a low-temperature photothermal treatment (PTT, 45 °C) is utilized with red phosphorus nanoparticles to resensitize methicillin-resistant (MRSA) to conventional aminoglycoside antibiotics. Read More

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http://dx.doi.org/10.1002/advs.201902070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201259PMC

Emerging Technologies for Real-Time Intraoperative Margin Assessment in Future Breast-Conserving Surgery.

Adv Sci (Weinh) 2020 May 17;7(9):1901519. Epub 2020 Mar 17.

Biofunctional Synthetic Chemistry Laboratory RIKEN Cluster for Pioneering Research 2-1 Hirosawa Wako Saitama 351-0198 Japan.

Clean surgical margins in breast-conserving surgery (BCS) are essential for preventing recurrence. Intraoperative pathologic diagnostic methods, such as frozen section analysis and imprint cytology, have been recognized as crucial tools in BCS. However, the complexity and time-consuming nature of these pathologic procedures still inhibit their broader applicability worldwide. Read More

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http://dx.doi.org/10.1002/advs.201901519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201251PMC

Magnetically Controlled On-Demand Switching of Batteries.

Adv Sci (Weinh) 2020 Apr 28;7(8):2000184. Epub 2020 Feb 28.

College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China.

The integration of stimuli-responsiveness into energy storage devices has become an attractive way to manage the operation of devices. Current stimuli approaches (light, chemical, and temperature) require transparent windows and specific systems, or are subject to the tolerant temperature of batteries, hampering their widespread applications. Herein, a fast and reversible on-demand switching of batteries, which is realized by incorporating a magnetic control component, is reported. Read More

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http://dx.doi.org/10.1002/advs.202000184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175272PMC

Advanced Near-Infrared Light for Monitoring and Modulating the Spatiotemporal Dynamics of Cell Functions in Living Systems.

Adv Sci (Weinh) 2020 Apr 27;7(8):1903783. Epub 2020 Feb 27.

CAS Key Laboratory of Nano-Bio Interface Division of Nanobiomedicine and i-Lab CAS Center for Excellence in Brain Science Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China.

Light-based technique, including optical imaging and photoregulation, has become one of the most important tools for both fundamental research and clinical practice, such as cell signal sensing, cancer diagnosis, tissue engineering, drug delivery, visual regulation, neuromodulation, and disease treatment. In particular, low energy near-infrared (NIR, 700-1700 nm) light possesses lower phototoxicity and higher tissue penetration depth in living systems as compared with ultraviolet/visible light, making it a promising tool for in vivo applications. Currently, the NIR light-based imaging and photoregulation strategies have offered a possibility to real-time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy. Read More

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http://dx.doi.org/10.1002/advs.201903783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175256PMC

From Sequence-Defined Macromolecules to Macromolecular Pin Codes.

Adv Sci (Weinh) 2020 Apr 3;7(8):1903698. Epub 2020 Mar 3.

Polymer Chemistry Research group (PCR) Centre of Macromolecular Chemistry (CMaC) Department of Organic and Macromolecular Chemistry Faculty of Sciences Ghent University Krijgslaan 281-S4bis Ghent 9000 Belgium.

Dynamic sequence-defined oligomers carrying a chemically written pin code are obtained through a strategy combining multicomponent reactions with the thermoreversible addition of 1,2,4-triazoline-3,5-diones (TADs) to indole substrates. The precision oligomers are specifically designed to be encrypted upon heating as a result of the random reshuffling of the TAD-indole covalent bonds within the backbone, thereby resulting in the scrambling of the encoded information. The encrypted pin code can eventually be decrypted following a second heating step that enables the macromolecular pin code to be deciphered using 1D electrospray ionization-mass spectrometry (ESI-MS). Read More

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http://dx.doi.org/10.1002/advs.201903698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175230PMC

Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study.

Adv Sci (Weinh) 2020 Apr 9;7(8):1903697. Epub 2020 Mar 9.

Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich Switzerland.

Trimethylamine (TMA) is a metabolite overtly present in patients suffering from trimethylaminuria (TMAU), a rare genetic disorder characterized by a strong "fishy" body odor. To date, no approved pharmacological treatment to sequester excess TMA on the skin of patients exists. Here, transmembrane pH gradient poly(isoprene)--poly(ethylene glycol) (PI--PEG) polymersomes are investigated for the topical removal of TMA. Read More

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http://dx.doi.org/10.1002/advs.201903697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175261PMC

CACCT: An Automated Tool of Detecting Complicated Cardiac Malformations in Mouse Models.

Adv Sci (Weinh) 2020 Apr 20;7(8):1903592. Epub 2020 Feb 20.

State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China.

Congenital heart disease (CHD) is the major cause of morbidity/mortality in infancy and childhood. Using a mouse model to uncover the mechanism of CHD is essential to understand its pathogenesis. However, conventional 2D phenotyping methods cannot comprehensively exhibit and accurately distinguish various 3D cardiac malformations for the complicated structure of heart cavity. Read More

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http://dx.doi.org/10.1002/advs.201903592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175298PMC

Near-Infrared Chemiluminescent Carbon Nanodots and Their Application in Reactive Oxygen Species Bioimaging.

Adv Sci (Weinh) 2020 Apr 9;7(8):1903525. Epub 2020 Mar 9.

Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials Physics Ministry of Education School of Physics and Microelectronics Zhengzhou University Zhengzhou 450052 China.

Reactive oxygen species (ROS) are generated in the body and related to many pathophysiological processes. Hence, detection of ROS is indispensable in understanding, diagnosis, and treatment of many diseases. Here, near-infrared (NIR) chemiluminescent (CL) carbon nanodots (CDs) are fabricated for the first time and their CL quantum yield can reach 9. Read More

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http://dx.doi.org/10.1002/advs.201903525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175254PMC