685,081 results match your criteria Advanced Nonlinear Studies[Journal]

Adjuvant versus Neoadjuvant Immunotherapy for Hepatocellular Carcinoma: Clinical and Immunologic Perspectives.

Semin Liver Dis 2021 Jun 15. Epub 2021 Jun 15.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.

Advancement in systemic therapy, particularly immune checkpoint inhibitor (ICI)-based combination regimens, has transformed the treatment landscape for patients with advanced hepatocellular carcinoma (HCC). The advancement in systemic therapy also provides new opportunities of reducing recurrence after curative therapy through adjuvant therapy or improving resectability through neoadjuvant therapy. Improved recurrence-free survival by adjuvant or neoadjuvant ICI-based therapy has been reported in other cancer types. Read More

View Article and Full-Text PDF

Teratomatous Elements in Orchiectomy Specimens Are Associated with a Reduced Relapse-Free Survival in Metastasized Testicular Germ Cell Tumors.

Urol Int 2021 Jun 15:1-7. Epub 2021 Jun 15.

Department of Urology, Uro-Oncology, Robot Assisted and Reconstructive Urologic Surgery, University Hospital Cologne, Cologne, Germany.

Introduction: The impact of teratomatous elements in orchiectomy specimens of metastasized testicular germ cell tumors (TGCT) regarding oncological outcome is still unclear.

Methods: We performed a retrospective analysis including 146 patients with metastasized TGCT analysing patient characteristics.

Results: Twenty-six (18%) of all patients showed teratomatous elements in the orchiectomy specimens. Read More

View Article and Full-Text PDF

White Matter Hyperintensities after Five-Year Follow-Up and a Cross-Sectional FA Decrease in Bipolar I and Major Depressive Patients.

Neuropsychobiology 2021 Jun 15:1-12. Epub 2021 Jun 15.

Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Introduction: An increase in brain white matter hyperintensities (WMHs) and a decrease in white matter fractional anisotrophy (FA) have been detected in bipolar I (BPI), II (BPII), and major depressive disorder (MDD) patients. Their relationship, and differences in diagnostic groups are obscure. Longitudinal studies are rare. Read More

View Article and Full-Text PDF

Multimaterial bioprinting towards the fabrication of biomimetic tissues and organs.

Biofabrication 2021 Jun 15. Epub 2021 Jun 15.

UCLA, 570 Westwood Plaza, Los Angeles, California, 90095, UNITED STATES.

Tissue reconstruction requires the utilization of multiple biomaterials and cell types to replicate the delicate and complex structure of native tissues. Various three-dimensional (3D) bioprinting techniques have been developed to fabricate customized tissue structures; however, there are still significant challenges, such as vascularization, mechanical stability of printed constructs, and fabrication of gradient structures to be addressed for the creation of biomimetic and complex tissue constructs. One approach to address these challenges is to develop multimaterial 3D bioprinting techniques that can integrate various types of biomaterials and bioprinting capabilities towards the fabrication of more complex structures. Read More

View Article and Full-Text PDF

Design study of a PET detector with 0.5 mm crystal pitch for high-resolution preclinical imaging.

Phys Med Biol 2021 Jun 15. Epub 2021 Jun 15.

Institute of Biomedical Engineering , Shenzhen Bay Laboratory, Shenzhen, CHINA.

Preclinical positron emission tomography (PET) is a sensitive and quantitative molecule imaging modality widely used in characterizing the biological processes and diseases in small animals. The purpose of this study is to investigate the methods to optimize a PET detector for high-resolution preclinical imaging. The PET detector proposed in this study consists of a 28×28 array of LYSO crystals 0. Read More

View Article and Full-Text PDF

Stimulus-Induced Rhythmic or Periodic Intermittent Discharges (SIRPIDs) in patients with triphasic waves and Creutzfeldt-Jakob disease.

Clin Neurophysiol 2021 May 20;132(8):1757-1769. Epub 2021 May 20.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Since the term Stimulus-Induced Rhythmic, Periodic, or Ictal Discharges (SIRPIDs) was introduced into the vocabulary of electrophysiologists/neurologists, there has been an ongoing debate about its significance, as well as its correlation with outcomes. SIRPIDs are frequently seen in patients who are critically ill from various causes. The literature reflects the findings of triphasic morphology, with the generalized periodic discharge (GPD) classification in many patients with SIRPIDs: toxic/metabolic encephalopathies, septic, and hypoxemic/hypercapnic encephalopathies, but also sharp periodic complexes in Creutzfeldt-Jakob disease and advanced Alzheimer's disease. Read More

View Article and Full-Text PDF

Advances in the study of GPCRs by F NMR.

Curr Opin Struct Biol 2021 Jun 12;69:169-176. Epub 2021 Jun 12.

Department of Chemistry, University of Toronto, Canada. Electronic address:

Crystallography and cryo-electron microscopy have advanced atomic resolution perspectives of inactive and active states of G protein-coupled receptors (GPCRs), alone and in complex with G proteins or arrestin. F NMR can play a role in ascertaining activation mechanisms and understanding the complete energy landscape associated with signal transduction. Fluorinated reporters are introduced biosynthetically via fluorinated amino acid analogs or chemically, via thiol-specific fluorinated reporters. Read More

View Article and Full-Text PDF

Alteration of brain structural connectivity in progression of Parkinson's disease: A connectome-wide network analysis.

Neuroimage Clin 2021 Jun 6;31:102715. Epub 2021 Jun 6.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disease, Beijing, China. Electronic address:

Pinpointing the brain dysconnectivity in idiopathic rapid eye movement sleep behaviour disorder (iRBD) can facilitate preventing the conversion of Parkinson's disease (PD) from prodromal phase. Recent neuroimage investigations reported disruptive brain white matter connectivity in both iRBD and PD, respectively. However, the intrinsic process of the human brain structural network evolving from iRBD to PD still remains largely unknown. Read More

View Article and Full-Text PDF

Study on the influence of advanced treatment processes on the surface properties of polylactic acid for a bio-based circular economy for plastics.

Ultrason Sonochem 2021 Jun 10;76:105627. Epub 2021 Jun 10.

Clausthal Centre for Materials Technology (CZM), Clausthal University of Technology, Leibnizstr. 9, 38678 Clausthal-Zellerfeld, Germany; School of Chemical Engineering, National Technical University of Athens, 9 Heroon Polytechneiou St., Zografou Campus, 15780 Athens, Greece. Electronic address:

New biotechnological processes using microorganisms and/or enzymes to convert carbonaceous resources, either biomass or depolymerized plastics into a broad range of different bioproducts are recognized for their high potential for reduced energy consumption and reduced GHG emissions. However, the hydrophobicity, high molecular weight, chemical and structural composition of most of them hinders their biodegradation. A solution to reduce the impact of non-biodegradable polymers spread in the environment would be to make them biodegradable. Read More

View Article and Full-Text PDF

Nitrogen-carbon materials base on pyrolytic graphene hydrogel for oxygen reduction.

J Colloid Interface Sci 2021 Jun 8;602:274-281. Epub 2021 Jun 8.

Lab of Advanced Nano-structures & Transfer Processes, Department of Chemical Engineering, Tianjin University, Tianjin 300354, China; Chemistry and Chemical Engineering Guangdong Laboratory, Shantou 515031 China. Electronic address:

Hypothesis: Oxygen reduction reaction (ORR) has played a significant role in the utilization of energy nowadays. Nitrogen-doped carbon materials are seen as promising catalysts for ORR, so it is of great significance in studying the functions of different nitrogen moieties.

Experiments: The graphene hydrogel-based nitrogen-arbon materials (GH N-C) were fabricated by first obtaining a gel through hydrothermal treatment using graphene oxide (GO) as precursor, and then calcined in an ammonia atmosphere at different temperatures to form N-doped graphitized materials with divers nitrogen configuration. Read More

View Article and Full-Text PDF

Treatment breaks in first line treatment of advanced colorectal cancer: An individual patient data meta-analysis.

Cancer Treat Rev 2021 May 19;99:102226. Epub 2021 May 19.

MRC Clinical Trials Unit at UCL, United Kingdom. Electronic address:

Background: Intermittent systemic anti-cancer therapy in patients with advanced colorectal cancer (aCRC) may improve quality of life without compromising overall survival (OS). We aimed to use individual patient data meta-analysis (IPDMA) from multiple randomised controlled trials evaluating intermittent strategies to inform clinical practice. We also aimed to validate whether thrombocytosis as a predictive biomarker identified patients with significantly reduced OS receiving a complete treatment break. Read More

View Article and Full-Text PDF

Microplastic degradation methods and corresponding degradation mechanism: Research status and future perspectives.

J Hazard Mater 2021 Jun 10;418:126377. Epub 2021 Jun 10.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Institute of Eco-Environmental Research, Guangxi Academy of Sciences, Nanning 530007, China. Electronic address:

Microplastics (MPs) pollution has become a global environmental concern because of their severe threat to biota. However, limited studies on the elimination of MPs pollution were reported. The conventional treatment methods were not suitable for MPs owing to their smaller size than plastic items. Read More

View Article and Full-Text PDF

Extensive sex-specific and regional variations observed in the microbiome of Dermacentor reticulatus.

Ticks Tick Borne Dis 2021 Jun 4;12(5):101767. Epub 2021 Jun 4.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical, Sciences, Texas A&M University, College Station, TX, 77843, USA. Electronic address:

Recent progress in DNA sequencing technologies and advanced bioinformatic tools have enabled researchers to rapidly decipher the tick microbiome. To date, however, a number of microbiome studies performed on Dermacentor reticulatus ticks is still quite limited. Despite the importance of this ixodid tick for veterinary and human medicine, only two investigations have examined its microbiome. Read More

View Article and Full-Text PDF

Delivery of a spheroids-incorporated human dermal fibroblast sheet increases angiogenesis and M2 polarization for wound healing.

Biomaterials 2021 Jun 7;275:120954. Epub 2021 Jun 7.

School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi, 16419, Republic of Korea. Electronic address:

Low cell engraftment is a major problem in tissue engineering. Although various methods related with cell sheets have been attempted to resolve the issue, low cell viability due to oxygen and nutrient depletion remains an obstacle toward advanced therapeutic applications. Cell therapy using fibroblasts is thought of as a good alternative due to the short doubling times of fibroblasts together with their immunomodulatory properties. Read More

View Article and Full-Text PDF

One-pot synthesis of sodium alginate-grafted-terpolymer hydrogel for As(III) and V(V) removal: In situ anchored comonomer and DFT studies on structures.

J Environ Manage 2021 Jun 12;294:112932. Epub 2021 Jun 12.

Advanced Polymer Laboratory, Department of Polymer Science and Technology, Government College of Engineering and Leather Technology (Post-Graduate), Maulana Abul Kalam Azad University of Technology, Salt Lake, Kolkata 700106, West Bengal, India. Electronic address:

In this work, an optimum sodium alginate (NaAlg)-grafted-[sodium 2-methylenesuccinate-co-sodium 2-((2-(isobutyryloxy)ethoxy)methyl)succinate-co-ethylene glycol methacrylate, i.e., SMS-co-SIBEMS-co-EGMA, i. Read More

View Article and Full-Text PDF

Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatient/ambulatory) residents.

Med Hypotheses 2021 Jun 5;153:110622. Epub 2021 Jun 5.

Concerned Ontario Doctors, Toronto, ON, Canada. Electronic address:

The outbreak of COVID-19 from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread all over the world with tremendous morbidity and mortality in the elderly. In-hospital treatment addresses the multifaceted nature of the illness including initial viral replication, cytokine storm, and endothelial injury with thrombosis. We identified nine reports of early treatment outcomes in COVID-19 nursing home patients. Read More

View Article and Full-Text PDF

Facile and rapid detection of SARS-CoV-2 antibody based on a noncompetitive fluorescence polarization immunoassay in human serum samples.

Biosens Bioelectron 2021 Jun 5;190:113414. Epub 2021 Jun 5.

Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo, 060-8628, Japan; Innovative Research Centre for Preventive Medical Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan; Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. Electronic address:

Antibody detection methods for viral infections have received broad attention due to the COVID-19 pandemic. In addition, there remains an ever-increasing need to quantitatively evaluate the immune response to develop vaccines and treatments for COVID-19. Here, we report an analytical method for the rapid and quantitative detection of SARS-CoV-2 antibody in human serum by fluorescence polarization immunoassay (FPIA). Read More

View Article and Full-Text PDF

Noreudesmane sesquiterpenoids from Artemisia hedinii and their anti-inflammatory activities.

Fitoterapia 2021 Jun 12:104961. Epub 2021 Jun 12.

State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address:

Ten undescribed noreudesmane-type sesquiterpenoids, including eight 12,13-dinoreudesmanes and a pair of 11,12,13-trinoreudesmane epimers were isolated from the whole plant of Artemisia hedinii. Their structures were elucidated by extensive analysis of spectroscopic data, including MS, 1D and 2D NMR, and their absolute configurations were confirmed by X-ray diffraction experiments and DFT calculations. Compounds 1-5, 7-10 were evaluated for their anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated murine macrophages RAW264. Read More

View Article and Full-Text PDF

Vascularized Carotid Atherosclerotic Plaque Models for the Validation of Novel Methods of Quantifying Intra-Plaque Neovascularization.

J Am Soc Echocardiogr 2021 Jun 12. Epub 2021 Jun 12.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada;; Department of Medicine, Cardiovascular Imaging Network at Queen's (CINQ), Queen's University, Canada. Electronic address:

Background: Intraplaque neovascularization (IPN) in advanced lesions of the carotid artery has been linked to plaque progression and risk of rupture. Quantitative measurement of IPN may provide a more powerful tool for the detection of such "vulnerable" plaque than the current visual scoring grading method. The aim of this study was to develop a phantom platform of a neovascularized atherosclerotic plaque within a carotid artery to assess new methods of quantifying IPN. Read More

View Article and Full-Text PDF

Artificial Intelligence in Pathology: Easing the Burden of Annotation Running Title: AI Annotation Reduction.

Am J Pathol 2021 Jun 12. Epub 2021 Jun 12.

Emeritus Professor, Rutgers-NJMS; Department of Pathology and Laboratory Medicine Adjunct Professor, Perelman Medical School; Adjunct Professor, Sidney Kimmel School of Medicine, Philadelphia, PA. Electronic address:

The need for huge datasets represents a bottleneck for applications of artificial intelligence. In Pathology, an additional problem is that there are often substantially fewer annotated target lesions than normal tissues for comparison. Organic brains overcome these limitations by utilizing large numbers of specialized neural nets arranged in both linear and parallel fashion, with each solving a restricted classification problem. Read More

View Article and Full-Text PDF

Antibody Responses After mRNA-Based COVID-19 Vaccination in Residential Older Adults: Implications for Reopening.

J Am Med Dir Assoc 2021 Jun 12. Epub 2021 Jun 12.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Clinical Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Objective: COVID-19 disproportionately impacts residents in long-term care facilities. Our objective was to quantify the presence and magnitude of antibody response in vaccinated, older adult residents at assisted living, personal care, and independent living communities.

Design: A cross-sectional quality improvement study was conducted March 15 - April 1, 2021 in the greater Pittsburgh region. Read More

View Article and Full-Text PDF

Molecular classification and diagnostics of upper urinary tract urothelial carcinoma.

Cancer Cell 2021 Jun;39(6):793-809.e8

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.

Upper urinary tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Its molecular pathogenesis, however, is poorly understood, with no useful biomarkers available for accurate diagnosis and molecular classification. Through an integrated genetic study involving 199 UTUC samples, we delineate the landscape of genetic alterations in UTUC enabling genetic/molecular classification. Read More

View Article and Full-Text PDF

Fertility decline in sub-Saharan Africa: Does remarriage matter?

Popul Stud (Camb) 2021 Jun 15:1-21. Epub 2021 Jun 15.

Université du Québec à Montréal.

The interplay between remarriage and fertility is among the most poorly documented subjects in sub-Saharan Africa (SSA), despite remarriage being one of the fundamental aspects of marriage dynamics in this region. We use Demographic and Health Survey data from 34 countries in SSA to document the association between remarriage and fertility during the reproductive years and over the fertility transition. The findings show that in 29 countries, remarried women end up having fewer children than women in intact unions, despite attaining similar or higher levels of fertility at early reproductive ages. Read More

View Article and Full-Text PDF

Stimuli-responsive surfaces for switchable wettability and adhesion.

J R Soc Interface 2021 Jun 16;18(179):20210162. Epub 2021 Jun 16.

Centre of Advanced Structural Ceramics, Department of Materials, Imperial College London, London SW7 2AZ, UK.

Diverse unique surfaces exist in nature, e.g. lotus leaf, rose petal and rice leaf. Read More

View Article and Full-Text PDF

Structural basis for the coiled-coil architecture of human CtIP.

Open Biol 2021 Jun 16;11(6):210060. Epub 2021 Jun 16.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

The DNA repair factor CtIP has a critical function in double-strand break (DSB) repair by homologous recombination, promoting the assembly of the repair apparatus at DNA ends and participating in DNA-end resection. However, the molecular mechanisms of CtIP function in DSB repair remain unclear. Here, we present an atomic model for the three-dimensional architecture of human CtIP, derived from a multi-disciplinary approach that includes X-ray crystallography, small-angle X-ray scattering (SAXS) and diffracted X-ray tracking (DXT). Read More

View Article and Full-Text PDF

Spontaneous subcapital femoral neck fracture complicating osteonecrosis of femoral head.

Acta Orthop Belg 2021 Mar;87(1):25-34

Spontaneous subcapital fracture (SSF) of femoral neck in pre-existent osteonecrosis of femoral head (ONFH) is a rare presentation. Only a few cases have been reported so far and majority of them have been reported to have unilateral hip involvement. We retrospectively reviewed clinical-radiological data of 10 patients (12 hips) with SSF complicating ONFH. Read More

View Article and Full-Text PDF

Capture and Separation of SO2 Traces in Metal-Organic Frameworks via Pre-synthetic Pore Environment Tailoring by Methyl Groups.

Angew Chem Int Ed Engl 2021 Jun 15. Epub 2021 Jun 15.

Universität Düsseldorf, Institut für Anorganische Chemie und Strukturchemie, Universitätsstr. 1, 40225, Düsseldorf, GERMANY.

Herein, we report a pre-synthetic pore environment design strategy to achieve stable methyl-functionalized metal-organic frameworks (MOFs) for preferential SO2 binding and thus enhanced low (partial) pressure SO2 adsorption and SO2/CO2 separation. The enhanced sorption performance is for the first time attributed to an optimal pore size by increasing methyl group densities at the benzenedicarboxylate linker in [Ni2(BDC-X)2DABCO] (BDC-X = mono-, di- and tetramethyl-1,4-benzenedicarboxylate/terephthalate; DABCO = 1,4-diazabicyclo[2,2,2]octane). Monte Carlo simulations and first-principles density-functional theory (DFT) calculations demonstrate the key role of methyl groups within the pore surface on the preferential SO2 affinity over the parent MOF. Read More

View Article and Full-Text PDF

Paradigm shift in the management of metastatic Non-small Cell Lung Cancer.

Int J Clin Pract 2021 Jun 15:e14533. Epub 2021 Jun 15.

William Beaumont Hospital, Department of Hematology and Medical Oncology, Royal Oak.

Background: Lung cancer is one of the leading causes of cancer mortality in the US. The use of precision medicine in the past 10 years has significantly changed the therapeutic landscape of lung cancer. Management of advanced non-small cell lung cancer (NSCLC) has transitioned from a chemotherapeutic approach to targeted treatments and immunotherapeutic agents. Read More

View Article and Full-Text PDF

Effect of orofacial physiotherapeutic and hygiene interventions on oral health related quality of life in patients with Parkinson's disease. A randomised controlled trial.

J Oral Rehabil 2021 Jun 15. Epub 2021 Jun 15.

Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Parkinson's disease (PD) has a negative effect on oral health and orofacial function, but the subjective experience of orofacial symptoms and their impact on the quality of life is not fully investigated. In addition, knowledge of how to improve the subjective oral symptoms is lacking.

Objectives: To assess the self-reported orofacial function and oral health in patients with PD. Read More

View Article and Full-Text PDF