774,263 results match your criteria Advanced Nonlinear Studies[Journal]

Republic of Singapore Air Force Helicopter Search-and-Rescue and Medical Evacuations: A 5-Year Review.

Air Med J 2022 Jul-Aug;41(4):350-358. Epub 2022 May 27.

Republic of Singapore Air Force, Singapore.

The Republic of Singapore Air Force (RSAF) provides Helicopter Search-and-Rescue (SAR) and Helicopter Medical Evacuation (Heli-Medevac) coverage for the Singapore Aeronautical Search and Rescue Region (ASSR) in the South China Sea, spanning 840,000 km. This region contains busy international shipping lanes and air traffic routes. Each year, Singapore's Helicopter SAR and Heli-Medevac service is activated multiple times to rescue personnel lost at sea or to evacuate ill and injured ship sailors or passengers to tertiary hospitals in Singapore for stabilization and advanced care. Read More

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Nivolumab in patients with relapsed or refractory peripheral T-cell lymphoma: modest activity and cases of hyperprogression.

J Immunother Cancer 2022 Jun;10(6)

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Peripheral T-cell lymphomas (PTCL), a heterogeneous group of mature aggressive non-Hodgkin's lymphomas, carry a worse prognosis for most subtypes when compared with their B-cell counterparts. Despite recent approval of newer therapies, the outlook for patients with relapsed/refractory (RR) PTCL remains poor and new treatment strategies are clearly needed. Targeting the profoundly immunosuppressive tumor microenvironment in PTCL is one such approach. Read More

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Nurse driven outpatient wound center: Reducing readmission with wound care excellence.

J Vasc Nurs 2022 Jun 23;40(2):100-104. Epub 2022 May 23.

University of Maryland Medical Center, Baltimore, MD, USA.

There is a growing need for new and innovative ways to care for patients in the ambulatory setting, including providing wound care for patients. A vascular surgery department in a large urban academic medical center noted there was an increasing number of patients with chronic wounds that needed weekly care. The number of patients, the time needed to provide wound care, and limited clinic space was creating a strain on traditional clinic hours. Read More

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Phase I trial of daily subcutaneous SPL-108 injections in combination with paclitaxel in patients with platinum resistant CD44+ advanced ovarian epithelial cancer.

Int J Gynecol Cancer 2022 Jun 24. Epub 2022 Jun 24.

City of Hope National Medical Center, Duarte, California, USA

Objective: Preclinical evidence and early clinical trials have demonstrated the activity of SPL-108, a targeted agent that inhibits CD44 mediated induction of multidrug resistance specifically to paclitaxel and platinum agents. We conducted a phase I, open label, dose escalation study of the safety and tolerability of the combination of SPL-108 with weekly paclitaxel in patients with platinum resistant CD44+ ovarian, primary peritoneal, or fallopian tube cancer.

Methods: Patients with platinum resistant histologically proven epithelial ovarian, primary peritoneal, or fallopian tube cancers and measurable disease according to RECIST (Response Evaluation Criteria in Solid Tumours) version 1. Read More

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Artificial Intelligence in Meta-optics.

Chem Rev 2022 Jun 24. Epub 2022 Jun 24.

Department of Electrical Engineering, City University of Hong Kong, Kowloon, Hong Kong 999077.

Recent years have witnessed promising artificial intelligence (AI) applications in many disciplines, including optics, engineering, medicine, economics, and education. In particular, the synergy of AI and meta-optics has greatly benefited both fields. Meta-optics are advanced flat optics with novel functions and light-manipulation abilities. Read More

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The impact of the COVID-19 pandemic on heart failure management: Global experience of the OPTIMIZE heart failure care network.

Int J Cardiol 2022 Jun 21. Epub 2022 Jun 21.

Heart Failure and Transplant Clinics, St. Boniface Hospital, and Section of Cardiology, University of Manitoba, Winnipeg, MB, Canada.

During the COVID-19 pandemic, reductions in heart failure (HF) hospitalizations have been widely reported, and there is an urgent need to understand how HF care has been reorganized in countries with different infection levels, vaccination rates and healthcare services. The OPTIMIZE Heart Failure Care program has a global network of investigators in 42 countries, with first-hand experience of the impact of the pandemic on HF management in different care settings. The national coordinators were surveyed to assess: 1) the challenges of the COVID-19 pandemic for continuity of HF care, from both a hospital and patient perspective; 2) the organizational changes enacted to ensure continued HF care; and 3) lessons learned for the future of HF care. Read More

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Single-cell RNA-Seq Reveals the Heterogeneity of Cell Communications between Schwann Cells and Fibroblasts within the Microenvironment in Vestibular Schwannoma.

Am J Pathol 2022 Jun 21. Epub 2022 Jun 21.

Otolaryngology Institute of Shanghai Jiao Tong University, the Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Vestibular schwannomas (VSs), which develop from Schwann cells (SCs) of the vestibular nerve, are the most prevalent benign tumors of the cerebellopontine angle and internal auditory canal. Despite advances in treatment, the cellular components and mechanisms of VS tumor progression remain unclear. Here, we performed single-cell RNA-seq on clinically surgically isolated VS samples and clarified their cellular composition in a sophisticated manner, including the heterogeneous Schwann cell subtypes. Read More

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OLHA (N-oleoylhistamine) modulates activity of mouse brain histaminergic neurons.

Neuropharmacology 2022 Jun 21:109167. Epub 2022 Jun 21.

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.

Histaminergic (HA) neurons are located in the tuberomamillary nucleus (TMN) of the posterior hypothalamus, from where they project throughout the whole brain to control wakefulness. We examined the effects of N-oleoylhistamine (OLHA), a non-enzymatic condensation product of oleic acid (OLA) and histamine, on activity of mouse HA neurons in brain slices. OLHA bidirectionally modulated the firing of HA neurons. Read More

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Remodeling of the hyomandibular skeleton and facial nerve positioning during embryonic and postembryonic development of teleost fish.

Dev Biol 2022 Jun 21. Epub 2022 Jun 21.

College of Liberal Arts and Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan. Electronic address:

The vertebrate skeleton changes its shape during development through the activities of chondrocytes, osteoblasts and osteoclasts. Although much is known about the mechanisms for differentiation in these cells, it is less understood how they behave in a region-specific manner to acquire unique bone shapes. To address this question, we investigated the development of the hyomandibular (Hm) system in zebrafish. Read More

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Surgical Training for bowel endometriosis: A new wet-lab model.

J Minim Invasive Gynecol 2022 Jun 21. Epub 2022 Jun 21.

Division of Gynecology, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals.

Study Objective: To demonstrate a new wet lab model for training in conservative bowel endometriosis surgery (shaving and discoid resection) DESIGN: Video demonstration MATERIALS AND METHODS: 1) Modeling deep infiltrating endometriosis using cryopreserved porcine rectum. 2) Conservative resection (shaving and discoid resection) using cold scissor and CO2 laser (free beam and fiber). 3) Discoid resection RESULTS: In this video we present a new training model for improving the surgical management of bowel endometriosis. Read More

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Performance of various fillers in ecological floating beds planted with Myriophyllum aquaticum treating municipal wastewater.

Sci Total Environ 2022 Jun 21:156827. Epub 2022 Jun 21.

Department of Applied Sciences, Northumbria University, United Kingdom of Great Britain and Northern Ireland.

The performance of different suspended fillers (zeolite, drinking water treatment residual, biochar, woodchip and stereo-elastic packing) and their combinations in treating municipal wastewater in ecological floating beds (Eco-FBs) planted with Myriophyllum aquaticum was assessed. Six sets of enhanced Eco-FBs were developed to assess the individual and synergistic effects of combinations of the various fillers and microorganisms on nutrient elimination. The results demonstrated mean TN, NH-N, TP and COD purification efficiencies of 99. Read More

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Removal of emerging pollutants by a 3-step system: Hybrid digester, vertical flow constructed wetland and photodegradation post-treatments.

Sci Total Environ 2022 Jun 21:156750. Epub 2022 Jun 21.

Dept. of Chemistry, Faculty of Sciences & CICA, University of A Coruña, E-15071 A Coruña, Galiza, Spain. Electronic address:

The removal of emerging pollutants from municipal wastewater was studied for the first time using a three-step pilot-scale system: 1) hybrid digester (HD) as first step, 2) subsurface vertical flow constructed wetland (VF) as second step, and 3) photodegradation (PD) unit as third step or post-treatment. The HD and VF units were built and operated in series with effluent recirculation at pilot scale. For the PD post-treatment, three alternatives were studied at lab-scale, i) UVC irradiation at 254 nm (0. Read More

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Assessment of long-term phosphorus budget changes influenced by anthropogenic factors in a coastal catchment of Osaka Bay.

Sci Total Environ 2022 Jun 21:156833. Epub 2022 Jun 21.

Graduate School of Advanced Science and Engineering, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8521, Japan.

Phosphorus usage is irreplaceable in agriculture; however, its excessive use leads to wastage of invaluable resources and significant soil surplus. Agronomic soil phosphorus surplus in Asian regions has a much higher level than the global average. And with rapid urbanization and population growth in the recent decades, Asian countries have seen a rise in environmental pollution levels also. Read More

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Multi-sectoral impact assessment of an extreme African dust episode in the Eastern Mediterranean in March 2018.

Sci Total Environ 2022 Jun 21:156861. Epub 2022 Jun 21.

Climate and Atmosphere Research Center (CARE-C), The Cyprus Institute, Nicosia 2121, Cyprus.

In late March 2018, a large part of the Eastern Mediterranean experienced an extraordinary episode of African dust, one of the most intense in recent years, here referred to as the "Minoan Red" event. The episode mainly affected the Greek island of Crete, where the highest aerosol concentrations over the past 15 yeas were recorded, although impacts were also felt well beyond this core area. Our study fills a gap in dust research by assessing the multi-sectoral impacts of sand and dust storms and their socioeconomic implications. Read More

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Soluble TREM2 levels reflect the recruitment and expansion of TREM2 macrophages that localize to fibrotic areas and limit NASH.

J Hepatol 2022 Jun 15. Epub 2022 Jun 15.

Department of Laboratory Medicine, KILM, Medical University Vienna, Vienna, Austria. Electronic address:

Background & Aims: Due to the complex multifactorial origin and an incomplete understanding of the underlying disease mechanisms, progression of non-alcoholic fatty liver disease (NAFLD) into advanced non-alcoholic steatohepatitis (NASH) and liver fibrosis is predicted to become the primary indication for liver transplantation. Hence, there is an unmet need to identify novel targets to improve treatment strategies.

Methods: In an unbiased approach using bulk RNA sequencing, the hepatic molecular response to lipid-dependent dietary intervention was assessed in mice. Read More

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Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits.

J Hepatol 2022 Jun 21. Epub 2022 Jun 21.

Department of Hepatology & Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and emerging as the leading cause of liver cirrhosis, liver transplantation and hepatocellular carcinoma (HCC). NAFLD is a metabolic disease and considered the hepatic manifestation of the metabolic syndrome; however, during the evolution of NAFLD from steatosis to nonalcoholic steatohepatitis (NASH), to more advanced stages of NASH with liver fibrosis, the immune system plays an integral role. Triggers for inflammation are rooted in hepatic (lipid overload, lipotoxicity, oxidative stress) and extrahepatic systems (gut-liver axis, adipose tissue, skeletal muscle), resulting in unique immune-mediated pathomechanisms in NAFLD. Read More

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Visible-light photooxidation of ciprofloxacin utilizing metal oxide incorporated sol-gel processed La-doped NaTaO nanoparticles: A comparative study.

Environ Res 2022 Jun 21:113718. Epub 2022 Jun 21.

Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80200, Jeddah, 21589, Saudi Arabia.

The supper dissemination of antibiotic waste in water resources has exponentially progressed the vital water and soil pollution that affect human health and the environment. Consequently, there have been several types of research anticipated for the green mineralization of such pollutants. Herein, we intended a surfactant-aided sol-gel formation of lanthanum-doped sodium tantalate (LNTO) nanocrystals. Read More

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Model-based quantitative optimization of deep brain stimulation and prediction of parkinson's states.

Neuroscience 2022 Jun 21. Epub 2022 Jun 21.

Department of Precision Instruments, Tsinghua University, Beijing, China. Electronic address:

Although the exact etiology of Parkinson's disease (PD) is still unknown, there are a variety of treatments available to alleviate its symptoms according to the development stage of PD. Deep brain stimulation (DBS), the most common surgical treatment for advanced PD, accurately locates and implants stimulating electrodes at specific targets in the brain to deliver high-frequency electrical stimulation that alters the excitability of the corresponding nuclei. However, for different patients and stages of PD development, there exists a choice of the optimal DBS protocol. Read More

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Phenoxyl mediators improve enzymatic degradation of organic pollutants: Effect and mechanism.

Int J Biol Macromol 2022 Jun 21. Epub 2022 Jun 21.

Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, Bedford Park, South Australia 5042, Australia.. Electronic address:

A mediation strategy can effectively overcome the low reaction activity of enzymes with nonspecific substrates. In this study, we demonstrated how phenol compounds can mitigate the substrate limitation of HRP in catalytic degradation of various organic pollutants. In a classical HRP/HO system, phenol and natural phenolic compounds (4-HBA & pHBA), exhibited up to over 100-fold enhancement in eliminating organic dyes and persistent antibiotics while the loading is only 2-5 wt%. Read More

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A biomass-derived Schiff base material composited with polylactic acid nanofiber membrane as selective fluorescent 'turn off/on' platform for Pb quantitative detection and characterization.

Int J Biol Macromol 2022 Jun 21. Epub 2022 Jun 21.

Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, China. Electronic address:

Herein, a biomass-derived compound Z1 is synthesized via 'one pot' method for detection Pb using fluorescence and visual dual-mode in aqueous solution. Z1 shows good response to Pb with a limit of detection (LOD) of 13.4 nM. Read More

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Regulating DNA methylation could reduce neuronal ischemia response and apoptosis after ischemia-reperfusion injury.

Gene 2022 Jun 21:146689. Epub 2022 Jun 21.

Department of Orthopaedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin 300052, P.R. China; Department of Orthopaedics, Shandong University Centre for Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China. Electronic address:

Background: Ischemia-reperfusion injury (IRI) is an important pathophysiological condition that can cause cell injury and large-scale tissue injury in the nervous system. Previous studies have shown that epigenetic regulation may play a role in the pathogenesis of IRI.

Methods: In this study, we isolated mouse cortical neurons and constructed an oxygen-glucose deprivation/reoxygenation (OGD) model to explore the change in DNA methylation and its effect on the expression of corresponding genes. Read More

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An unexpected adverse event during gastrointestinal endoscopy involving retrieval of dislodged endoscopic suture material from the trachea.

Endoscopy 2022 Jun 24. Epub 2022 Jun 24.

Advanced Endoscopy, Division of Gastroenterology & Hepatology, Minneapolis VA Medical Center and University of Minnesota, Minneapolis, Minnesota, USA.

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Long-term survival in non-human primates of stem cell-derived, MHC-unmatched corneal epithelial cell sheets.

Stem Cell Reports 2022 Jun 10. Epub 2022 Jun 10.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita City, Osaka 565-0871, Japan. Electronic address:

When corneal epithelial stem cells residing in the corneal limbus become dysfunctional, called a limbal stem cell deficiency (LSCD), corneal transparency is decreased, causing severe vision loss. Transplantation of corneal epithelial cell sheets (CEPS) derived from stem cells, including induced pluripotent stem cells, is a promising treatment for LSCD. However, the potential effect of human leukocyte antigen (HLA) concordance on CEPS transplantation has not been addressed. Read More

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Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan.

Pregnancy Hypertens 2022 Jun 17;29:54-60. Epub 2022 Jun 17.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Division of Perinatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.

Objectives: We aimed to evaluate the impact of hypertensive disorders of pregnancy (HDP) on short- and medium-term respiratory outcomes in extremely and very preterm infants using the Neonatal Research Network of Japan database.

Study Design: This was a population-based retrospective study of preterm infants weighing ≤ 1500 g born between 22 and 31 weeks of gestation between 2003 and 2017. After 1:1 stratification matching by four factors (maternal age, gestational age, parity, and year of delivery), a total of 5137 infants in each group (HDP and non-HDP groups) were selected. Read More

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Risk factors for delirium in elderly patients after lumbar spinal fusion.

Clin Neurol Neurosurg 2022 Jun 2;219:107318. Epub 2022 Jun 2.

Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Objective: To identify perioperative risk factors for postoperative delirium (POD) in patients aged 65 or older undergoing lumbar spinal fusion procedures.

Patients And Methods: A retrospective cohort analysis was performed on patients undergoing lumbar spinal fusion over an approximately three-year period at a single institution. Demographic and perioperative data were obtained from electronic medical records. Read More

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Designing and development of phthalimides as potent anti-tubulin hybrid molecules against malaria.

Eur J Med Chem 2022 Jun 15;239:114534. Epub 2022 Jun 15.

Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India. Electronic address:

Constant emergence of drug-resistant Plasmodium falciparum warrants urgent need for effective and inexpensive drugs. Herein, phthalimide (Pht) analogs possessing the bioactive scaffolds, benzimidazole and 1,2,3-triazole, were evaluated for in vitro and in vivo anti-plasmodial activity without any apparent hemolysis, or cytotoxicity. Analogs 4(a-e) inhibited the growth of 3D7 and RKL-9 strains at submicromolar concentrations. Read More

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Biological aging for risk prediction of first-ever intracerebral hemorrhage and cerebral infarction in advanced age.

J Stroke Cerebrovasc Dis 2022 Jun 21;31(8):106568. Epub 2022 Jun 21.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, United States; World Without Disease Accelerator (WWDA), The Janssen Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands and Leyden Laboratories, Leiden, the Netherlands.

Background And Objectives: successful interventions to prevent cerebrovascular disease and stroke require early identification of persons at risk before clinical manifestation of disease. The literature remains to be sparse on accessible plasma-based biomarkers for monitoring brain health and cerebrovascular disease in advanced age. We assessed the predictive value of biological age (BA) as an early indicator for cerebrovascular disease and risk of first-ever intracerebral hemorrhage (ICH) and cerebral infarction (CI) in advanced age and compared these relationships with chronological age (CA) and commonly used biomarkers including tau and Aβ40 and Aβ42. Read More

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Analysis of the immune checkpoint lymphocyte activation gene-3 (LAG-3) in endometrial cancer: An emerging target for immunotherapy.

Pathol Res Pract 2022 Jun 18;236:153990. Epub 2022 Jun 18.

Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. Electronic address:

Background: Lymphocyte activation gene-3 (LAG-3) is a novel molecule that participates in the immune escape of tumor cells and is a target for immunotherapy. However, the expression of LAG-3 in patients with endometrial cancer (EC) has not been comprehensively characterized.

Objectives: We elucidated the expression of LAG-3 and investigated its correlation with clinicopathological parameters, ProMisE subtypes, CD8 T-cell infiltration and relapse-free survival (RFS) in a retrospective cohort of 421 patients with endometrial cancer. Read More

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Co-construction of molecular-level uranyl-specific "nano-holes" with amidoxime and amino groups on natural bamboo strips for specifically capturing uranium from seawater.

J Hazard Mater 2022 Jun 17;437:129407. Epub 2022 Jun 17.

Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China; Institute of Advanced Marine Materials, Harbin Engineering University, 150001, China.

Efficiently capturing of uranium (VI) [U(VI)] from seawater elicits unparalleled attraction for sustaining the uplifted requirement for nuclear fuel. However, obtaining the abundant U(VI) resource from seawater has always seriously restricted by competitive adsorption from higher concentrations of competitors, especially vanadium (V) [V(V)]. Herein, based on amidoximized natural bamboo strips with hierarchical porous structure, the molecular-level uranyl-specific "nano-holes" was co-constructed by the intramolecular hydrogen bonds for specifically trapping U(VI) from seawater. Read More

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Metabolome and transcriptome analyses of plants grown in naturally attenuated soil after hydrogen fluoride exposure.

J Hazard Mater 2022 Jun 8;437:129323. Epub 2022 Jun 8.

Center for Sustainable Environment Research, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Graduate School of Energy and Environment, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Accidental chemical leaks and illegal chemical discharges are a global environmental issue. In 2012, a hydrogen fluoride leak in Gumi, South Korea, killed several people and contaminated the environment. This leak also led to a significant decline in crop yield, even after the soil concentration of hydrogen fluoride decreased to below the standard level following natural attenuation. Read More

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