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Taiwan J Obstet Gynecol 2022 May;61(3):555-556

Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan; School of Medicine, Fu Jen Catholic University, Hsinchuang, New Taipei City, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. Electronic address:

Taiwan J Obstet Gynecol 2022 May;61(3):551-554

Changhua Christian Hospital Reproductive Medicine Center, Taiwan.

Objective: Advanced maternal age and decreased ovarian reserve have been challenges for assisted reproductive technology (ART). Few cases, using autologous oocytes more than 46-years-old, have previously been reported. We seek to show how the age at which autologous oocytes may successfully be employed may be increasing. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):532-534

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.

Objective: We present a false-positive result at non-invasive prenatal testing (NIPT) due to maternal 17p12 microduplication.

Case Report: A 37-year-old, gravida 2, para 1, woman underwent amniocentesis at 19 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 46,XY. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):528-531

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.

Objective: We present prenatal diagnosis of high-level mosaicism for 45,X in 45,X/46,X,idic(Y)(q11.2) at amniocentesis in a pregnancy with a favorable outcome and postnatal progressive decrease of the 45,X cell line.

Case Report: A 36-year-old, gravida 4, para 3, woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):525-527

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.

Objective: We present perinatal cytogenetic discrepancy in a pregnancy with mosaic 45,X/46, XY at amniocentesis and a favorable outcome.

Case Report: A 38-year-old, primigravid woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 45,X[2]/46,XY[6]. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):494-500

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Branch and Chang Gung University, Taoyuan, Taiwan; Gynecologic Cancer Research Center, Chang Gung Memorial Hospital, Linkou Branch and Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: This study (Asian Gynecologic Oncology Group [AGOG]13-001/Taiwanese Gynecologic Oncology Group [TGOG]1006) was to validate human papillomavirus (HPV)16 as an independent good prognostic factor and investigate the impact of treatment modalities to cervical adenocarcinoma and adenosquamous carcinoma (AD/ASC).

Materials And Methods: Patients receiving primary treatment at AGOG and TGOG member hospitals for cervical AD/ASC were retrospectively (1993-2014) and prospectively (since 2014) enrolled. DNA extraction from paraffin-embedded tissue (FFPE) specimens was used for HPV genotyping. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):415-421

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

Objective: The prognostic implications of DNA mismatch repair protein (MMRP) have not been determined in endometrial cancer. Therefore, in this study, we aimed to evaluate the clinicopathologic characteristics of DNA MMRP deficiency in endometrial cancer.

Materials And Methods: We examined the MMRP status of 206 patients with endometrial carcinomas, using immunohistochemistry, and analyzed their clinicopathologic factors and survival outcomes stratified by MMRP status using the Kaplan-Meier method and Cox regression analysis. Read More

Gastroenterol Clin North Am 2022 Jun 22;51(2):283-298. Epub 2022 Apr 22.

Division of Gastroenterology, University of California, San Diego, 9500 Gilman Drive, MC 0956, La Jolla, CA 92093-0956, USA.

Over the past 2 decades, there have been incredible advances in the pharmacotherapeutic options for the treatment of patients with moderately to severely active Crohn's disease. Despite the leaps and strides in safety, efficacy, and mechanistic specificity of treatment targets, a significant portion (up to ∼20-50%) of patients have refractory Crohn's disease ± concomitant rheumatologic disease/extraintestinal manifestations for which existing biologic and small molecule therapies are ineffective. In this review, we will explore the available evidence for the use of dual advanced therapies (combination of biologic and/or small molecule therapies) and novel pharmacotherapies in phase 2 to 3 clinical trials. Read More

J Pain Symptom Manage 2022 Jun;63(6):e621-e632

Pulmonary, Critical Care & Sleep Medicine, Cambia Palliative Care Center of Excellence at UW Medicine (R.A.E.), University of Washington, Seattle, Seattle, Washington, USA.

Context: Outcomes after cardiopulmonary resuscitation (CPR) remain poor. We have spent 10 years investigating an "informed assent" (IA) approach to discussing CPR with chronically ill patients/families. IA is a discussion framework whereby patients extremely unlikely to benefit from CPR are informed that unless they disagree, CPR will not be performed because it will not help achieve their goals, thus removing the burden of decision-making from the patient/family, while they retain an opportunity to disagree. Read More

J Pain Symptom Manage 2022 Jun;63(6):e579-e586

Cambia Palliative Care Center of Excellence (N.K., R.A.E.), University of Washington, Harborview Medical Center, Seattle, Washington, USA; University of Washington, Department of Medicine (R.A.E.), Division of Pulmonary, Critical Care and Sleep Medicine, Seattle, Washington, USA.

Palliative care research is deeply challenging for many reasons, not the least of which is the conceptual and operational difficulty of measuring outcomes within a seriously ill population such as critically ill patients and their family members. This manuscript describes how Randy Curtis and his network of collaborators successfully confronted some of the most vexing outcomes measurement problems in the field, and by so doing, have enhanced clinical care and research alike. Beginning with a discussion of the clinical challenges of measurement in palliative care, we then discuss a selection of the novel measures developed by Randy and his collaborators and conclude with a look toward the future evolution of these concepts. Read More

J Pain Symptom Manage 2022 Jun;63(6):e577-e578

Palliative and Advanced Illness Research (PAIR) Center, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Department of Medical Ethics and Health Policy (S.D.H.),University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Anal Chim Acta 2022 Jun 30;1210:339884. Epub 2022 Apr 30.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei Province, PR China. Electronic address:

Zearalenone (ZEN) is a nonsteroidal estrogenic mycotoxin, and its accurate detection in complex biological samples is still a challenge. Herein, an antifouling ratiometric electrochemical sensor has been developed for its detection. In this system, black phosphorus-graphene oxide is used as substrate to amplify the signal; ionic liquid doped molecularly imprinted polymer (MIP) endows the sensing surface not only high recognition ability but also high capability to resist nonspecific adsorption. Read More

Prog Mol Biol Transl Sci 2022 22;189(1):259-326. Epub 2022 Apr 22.

The First Affiliated Hospital of Shantou University, Shantou University Medical College, Shantou, China; Department of Urology, Shenzhen Institute of Translational Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, China; International Cancer Center of Shenzhen University, Shenzhen, China; Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. Electronic address:

Cancer represents a leading cause of death, despite the rapid progress of cancer research, leading to urgent need for accurate preclinical model to further study of tumor mechanism and accelerate translational applications. Cancer cell lines cannot fully recapitulate tumors of different patients due to the lack of tumor complexity and specification, while the high technical difficulty, long time, and substantial cost of patient-derived xenograft model makes it unable to be used extensively for all types of tumors and large-scale drug screening. Patient-derived organoids can be established rapidly with a high success rate from many tumors, and precisely replicate the key histopathological, genetic, and phenotypic features, as well as therapeutic response of patient tumor. Read More

Prog Mol Biol Transl Sci 2022 25;189(1):101-154. Epub 2022 Mar 25.

Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.

During early embryonic development, late fetal growth, puberty, adult reproductive years, and advanced aging, bovine and human ovaries closely share molecular pathways and hormonal signaling mechanisms. Other similarities between these species include the size of ovaries, length of gestation, ovarian follicular and luteal dynamics, and pathophysiology of ovarian diseases. As an economically important agriculture species, cattle are a foundational species in fertility research with decades of groundwork using physiologic, genetic, and therapeutic experimental techniques. Read More

Air Med J 2022 May-Jun;41(3):308-314. Epub 2022 Mar 21.

Hemotherapy Service, University Hospital of the Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

Objective: Helicopter emergency medical services are part of many emergency health care systems, ensuring specialized treatment on site. The objective of this study was to develop and validate a protocol for the use of packed red blood cells in advanced support helicopter air medical care in Brazil.

Methods: This was a methodological validation study with a quantitative approach developed in 2 stages (ie, protocol development and content validity using the Delphi technique) by 24 judges. Read More

Eur Respir J 2022 May 20. Epub 2022 May 20.

Université Paris-Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France

Bioresour Technol 2022 May 17:127317. Epub 2022 May 17.

Shuifa Shandong Water Development Group Co. Ltd. Shandong, 274200, China.

In this study, a novel strategy of zero-valent iron (ZVI) combined with acetic acid was proposed to optimize partial-denitrification/anammox (PD/A) process, and enhanced nitrogen removal mechanism was elucidated through metagenomics. Results showed that the optimal nitrogen and phosphorus removal were as high as 99.50% and 98. Read More

Hum Reprod 2022 May 20. Epub 2022 May 20.

Reproductive Medical Center, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Study Question: Is a dual ovulation trigger with a combination of GnRH agonist (GnRHa) and hCG superior to single hCG and/or single GnRHa trigger in improving treatment outcomes in advanced-age women (aged ≥ 35 years) undergoing IVF/ICSI treatment?

Summary Answer: Co-administration of GnRHa and hCG as a dual trigger increases the number of good-quality embryos but it is not associated with a higher number of oocytes retrieved, compared with single hCG or GnRHa trigger.

What Is Known Already: Many studies have demonstrated that a dual trigger has positive impact on oocyte maturation, retrieval rate and pregnancy rate without increasing the risk of ovarian hyperstimulation syndrome (OHSS) in some groups of IVF patients, when compared with single hCG trigger. Few studies have however been conducted to compare a dual trigger with a single GnRHa trigger, and insufficient evidence exists to support which trigger can achieve the best outcomes in IVF patients aged ≥35 years. Read More

J Vasc Interv Radiol 2022 May 17. Epub 2022 May 17.

Department of Medical Imaging, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ 85724.

Purpose: To investigate the feasibility of percutaneous radiofrequency ablation (RFA) to occlude the thoracic duct (TD) in a swine model with imaging and histologic correlation.

Materials And Methods: Six swine underwent TD RFA. Two terminal (4 hours; 1 open, 1 percutaneous) and four survival (30 days; all percutaneous) studies were performed. Read More

Ann Vasc Surg 2022 May 17. Epub 2022 May 17.

University of Maryland School of Medicine; Division of Vascular Surgery, Department of Surgery, University of Maryland Medical Center.

Objective: Despite advancements in medical care and surgical techniques, major amputation continues to be associated with risks for morbidity and mortality. Palliative care programs may help alleviate symptoms and align patients' goals and the care they receive with their treatment plan. Access to specialty Palliative medicine among vascular surgery patients is limited . Read More

Ann Vasc Surg 2022 May 17. Epub 2022 May 17.

Department of Surgery, Advocate Lutheran General Hospital, Park Ridge, IL.

Objective: Chronic limb-threatening (CLTI) is associated with 25% limb loss and 25% mortality at 1-year. Its lethality increases to 45% in patients subjected to a major amputation. Percutaneous peripheral intervention (PPI) constitutes an attractive and less morbid treatment option for patients with CLTI. Read More

Ann Vasc Surg 2022 May 17. Epub 2022 May 17.

From the Advanced Endovascular Aortic Research Program Mayo Clinic, 200 1(st) St NW, Rochester, MN 55905. Electronic address:

Objectives: To evaluate outcomes following urgent or emergent fenestrated-branched endovascular aortic repair (F-BEVAR) for pararenal (PRA) and thoracoabdominal aortic aneurysms (TAAA) in patients considered high-risk for open repair.

Methods: A retrospective, single institution evaluation of outcomes following F-BEVAR of symptomatic, rapidly enlarging, or ruptured PRA or TAAA treated with physician modified endograft (PMEG) and company manufactured devices (CMD). Outcomes were technical success, 30-day morbidity and mortality, and one year aortic related outcomes. Read More

Neuroimage 2022 May 17:119306. Epub 2022 May 17.

Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, Germany.

Replicability and reproducibility of scientific findings is paramount for sustainable progress in neuroscience. Preregistration of the hypotheses and methods of an empirical study before analysis, the sharing of primary research data, and compliance with data standards such as the Brain Imaging Data Structure (BIDS), are considered effective practices to secure progress and to substantiate quality of research. We investigated the current level of adoption of open science practices in neuroimaging and the difficulties that prevent researchers from using them. Read More

Travel Med Infect Dis 2022 May 17:102358. Epub 2022 May 17.

Health Intervention and Technology Assessment Program (HITAP), 6th Floor, 6th Building, Department of Health, Ministry of Public Health, Tiwanon Road, Nonthaburi, 11000, Thailand; Saw Swee Hock School of Public Health (SSHSPH), National University of Singapore (NUS), 12 Science Drive 2, #10-01, 117549, Singapore.

Ageing Res Rev 2022 May 17:101648. Epub 2022 May 17.

Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, DE-72076 Tübingen, Germany. Electronic address:

After fifteen years of genome-wide association studies (GWAS) in Parkinson's disease (PD), what have we learned? Addressing this question will help catalogue the progress made towards elucidating disease mechanisms, improving the clinical utility of the identified loci, and envisioning how we can harness the strides to develop translational GWAS strategies. Here we review the advances of PD GWAS made to date while critically addressing the challenges and opportunities for next-generation GWAS. Thus, deciphering the missing heritability in underrepresented populations is currently at the reach of hand for a truly comprehensive understanding of the genetics of PD across the different ethnicities. Read More

Microb Pathog 2022 May 17:105592. Epub 2022 May 17.

Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address:

Heartland virus is a single-stranded negative-sense RNA virus that infects humans and causes lethargy, myalgia, headaches, nausea, diarrhea, weight loss, arthralgia, loss of appetite, leukopenia, and easy bruising due thrombocytopenia. The unavailability of antiviral drugs for HRTV infection is a major obstacle to treat this infection, therefore supportive care management is adopted in the case of a severe ailment. In this scientific study, proteins specific and proteome-wide Helper T-cell (HTL), linear B cell, and cytotoxic T-cell (CTL) epitopes mapping joined together with suitable linkers to design multi-epitopes subunit vaccine (MEVC). Read More

Sci Total Environ 2022 May 16:156010. Epub 2022 May 16.

Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran; Department of Environmental Engineering, Gebze Technical University, 41400 Gebze, Turkey.

Antibiotics and related pharmaceuticals are applied to enhance public health and life quality. A major environmental concern is wastewaters from pharmaceutical industries, which contain significant amounts of antibiotics. Pharmaceutical industries apply conventional processes (biological, filtration, coagulation, flocculation, and sedimentation) for wastewater treatment, but these approaches cannot remove antibiotics completely. Read More