2,765 results match your criteria Advanced Healthcare Materials[Journal]


Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics.

Adv Healthc Mater 2021 Jun 13:e2100598. Epub 2021 Jun 13.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se-based compounds often leads to toxicity. Read More

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Wireless Power Delivery Techniques for Miniature Implantable Bioelectronics.

Adv Healthc Mater 2021 Jun 10:e2100664. Epub 2021 Jun 10.

Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX, 77005, USA.

Progress in implanted bioelectronic technology offers the opportunity to develop more effective tools for personalized electronic medicine. While there are numerous clinical and pre-clinical applications for these devices, power delivery to these systems can be challenging. Wireless battery-free devices offer advantages such as a smaller and lighter device footprint and reduced failures and infections by eliminating lead wires. Read More

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Designing Inherently Photodegradable Cell-Adhesive Hydrogels for 3D Cell Culture.

Adv Healthc Mater 2021 Jun 10:e2100632. Epub 2021 Jun 10.

Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, Germany.

Light-based microfabrication techniques constitute an indispensable approach to fabricate tissue assemblies, benefiting from noncontact spatially and temporarily controlled manipulation of soft matter. Light-triggered degradation of soft materials, such as hydrogels, is important in tissue engineering, bioprinting, and related fields. The photoresponsiveness of hydrogels is generally not intrinsic and requires complex synthetic procedures wherein photoresponsive crosslinking groups are incorporated into the hydrogel. Read More

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Polymeric Micro/Nanomotors and Their Biomedical Applications.

Adv Healthc Mater 2021 Jun 10:e2100720. Epub 2021 Jun 10.

School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, China.

Since their naissance in the 2000s, various micro or nanomotors with powerful functions have been proposed. Among them, polymer-based micro or nanomotors stand out for the easy processing and facile functionalization, holding immense potential for bioapplications. In this review, fabrication of polymer-based micro or nanomotors and their applications in biomedical areas are covered. Read More

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Light-Regulated Angiogenesis via a Phototriggerable VEGF Peptidomimetic.

Adv Healthc Mater 2021 Jun 10:e2100488. Epub 2021 Jun 10.

INM - Leibniz Institute for New Materials, Saarbrücken, 66123, Germany.

The application of growth factor based therapies in regenerative medicine is limited by the high cost, fast degradation kinetics, and the multiple functions of these molecules in the cell, which requires regulated delivery to minimize side effects. Here a photoactivatable peptidomimetic of the vascular endothelial growth factor (VEGF) that allows the light-controlled presentation of angiogenic signals to endothelial cells embedded in hydrogel matrices is presented. A photoresponsive analog of the 15-mer peptidomimetic Ac-KLTWQELYQLKYKGI-NH (abbreviated QK) is prepared by introducing a 3-(4,5-dimethoxy-2-nitrophenyl)-2-butyl (DMNPB) photoremovable protecting group at the Trp4 residue. Read More

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Trifunctional Graphene Quantum [email protected] Integrated Nanoprobes for Visualization Therapy of Gastric Cancer.

Adv Healthc Mater 2021 Jun 10:e2100512. Epub 2021 Jun 10.

Research Center for Translational Medicine at East Hospital, Tongji University School of Life Science and Technology, Shanghai, 200092, China.

Visualization technology has become a trend in tumor therapy in recent years. The superior optical properties of graphene quantum dots (GQDs) make them suitable candidates for tumor diagnosis, but their tumor targeting and drug-carrying capacities are still not ideal for treatment. Sulfur-doped graphene quantum dots (SGQDs) with stable fluorescence are prepared in a previous study. Read More

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Rapid Characterization and Quantification of Extracellular Vesicles by Fluorescence-Based Microfluidic Diffusion Sizing.

Adv Healthc Mater 2021 Jun 10:e2100021. Epub 2021 Jun 10.

Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, Zürich, 8093, Switzerland.

Extracellular vesicles (EVs) are emerging as promising diagnostic and therapeutic tools for a variety of diseases. The characterization of EVs requires a series of orthogonal techniques that are overall time- and material-consuming. Here, a microfluidic device is presented that exploits the combination of diffusion sizing and multiwavelength fluorescence detection to simultaneously provide information on EV size, concentration, and composition. Read More

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Influence of the Modulation of the Protein Corona on Gene Expression Using Polyethylenimine (PEI) Polyplexes as Delivery Vehicle.

Adv Healthc Mater 2021 Jun 4:e2100125. Epub 2021 Jun 4.

Fachbereich Physik und Chemie and CHyN, Universität Hamburg, Notkestraße 85, Hamburg, 22607, Germany.

The protein corona can significantly modulate the physicochemical properties and gene delivery of polyethylenimine (PEI)/DNA complexes (polyplexes). The effects of the protein corona on the transfection have been well studied in terms of averaged gene expression in a whole cell population. Such evaluation methods give excellent and reliable statistics, but they in general provide the final transfection efficiency without reflecting the dynamic process of gene expression. Read More

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Dielectric Elastomer Actuators, Neuromuscular Interfaces, and Foreign Body Response in Artificial Neuromuscular Prostheses: A Review of the Literature for an In Vivo Application.

Adv Healthc Mater 2021 Jun 4:e2100041. Epub 2021 Jun 4.

Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW, 2522, Australia.

The inability to replace human muscle in surgical practice is a significant challenge. An artificial muscle controlled by the nervous system is considered a potential solution for this. Here, this is defined as a neuromuscular prosthesis. Read More

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DNA Nanotechnology-Based Biosensors and Therapeutics.

Adv Healthc Mater 2021 Jun 3:e2002205. Epub 2021 Jun 3.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30322, USA.

Over the past few decades, DNA nanotechnology engenders a vast variety of programmable nanostructures utilizing Watson-Crick base pairing. Due to their precise engineering, unprecedented programmability, and intrinsic biocompatibility, DNA nanostructures cannot only interact with small molecules, nucleic acids, proteins, viruses, and cancer cells, but also can serve as nanocarriers to deliver different therapeutic agents. Such addressability innate to DNA nanostructures enables their use in various fields of biomedical applications such as biosensors and cancer therapy. Read More

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Liquid Copolymers as Biodegradable Surgical Sealant.

Adv Healthc Mater 2021 Jun 3:e2100803. Epub 2021 Jun 3.

Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.

Surgical sealants are widely used to prevent seepage of fluids and liquids, promote hemostasis, and close incisions. Despite the remarkable progress the field of biomaterials has undergone, the clinical uses of surgical sealants are limited because of their short persistence time in vivo, toxicity, and high production costs. Here, the development of two complementary neat (solvent-free) prepolymers, PEG -PLGA-NHS and PEG -NH , that harden upon mixing to yield an elastic biodegradable sealant is presented. Read More

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Near-Infrared Light-Regulated Drug-Food Homologous Bioactive Molecules and Photothermal Collaborative Precise Antibacterial Therapy Nanoplatform with Controlled Release Property.

Adv Healthc Mater 2021 Jun 3:e2100546. Epub 2021 Jun 3.

College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.

Herein, a collaborative precise antibacterial wound healing therapy nanoplatform integrating drug-food homologous bioactive molecule (cinnamaldehyde, CA) with photothermal therapy (PTT) is presented. Copper-gallic acids-cinnamaldehyde-polydopamine nanorods (Cu-GA-CA-PDA NRs) with near-infrared light (NIR)-controlled CA release property are fabricated, which also integrate CA and photothermal synergistic sterilization, as well as antioxidant, anti-inflammatory, and anti-infection capacities. The characteristics of NIR-mediated CA release and photothermal response of Cu-GA-CA-PDA NRs support their excellent sterilization performance in vitro/in vivo. Read More

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Genetically Encoded Elastin-Like Polypeptides for Drug Delivery.

Adv Healthc Mater 2021 Jun 3:e2100209. Epub 2021 Jun 3.

Department of Biomedical Engineering, Duke University, Durham, NC, 277018, USA.

Elastin-like polypeptides (ELPs) are thermally responsive biopolymers that consist of a repeated amino acid motif derived from human tropoelastin. These peptides exhibit temperature-dependent phase behavior that can be harnessed to produce stimuli-responsive biomaterials, such as nanoparticles or injectable drug delivery depots. As ELPs are genetically encoded, the properties of ELP-based biomaterials can be controlled with a precision that is unattainable with synthetic polymers. Read More

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Recent Developments in Nanomaterial-Based Shear-Sensitive Drug Delivery Systems.

Adv Healthc Mater 2021 Jun 2:e2002196. Epub 2021 Jun 2.

Department of Materials Science and Engineering, Lehigh University, Bethlehem, PA, 18015, USA.

Nanomaterial-based drug delivery systems (DDSs) increase the efficacy of various therapeutics, and shear stress has been shown to be a robust modulator of payload release. In the past few decades, a deeper understanding has been gained of the effects of flow in the body and its alteration in pathological microenvironments. More recently, shear-responsive nanomaterial DDSs have been developed. Read More

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Biodegradable Copper-Based Nanoparticles Augmented Chemodynamic Therapy through Deep Penetration and Suppressing Antioxidant Activity in Tumors.

Adv Healthc Mater 2021 Jun 2:e2100412. Epub 2021 Jun 2.

Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin, 130022, China.

Chemodynamic therapy (CDT) efficacy has been limited by the poor penetration ability of large nanoparticles (NPs) and the antioxidant activity of tumors, especially high heme oxygenase (HO-1) and glutathione (GSH) levels. Herein, PEGylated CuMoO -coated and zinc protoporphyrin IX (ZP)-loaded Cu (CCMZ) NPs are designed to afford rapid degradation ability and augmented CDT efficacy through inhibiting HO-1 activity and depleting GSH. The deep penetration of tumor can be achieved under the high levels of GSH, which triggers the degradation of CuMoO shell. Read More

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Advanced Human BBB-on-a-Chip: A New Platform for Alzheimer's Disease Studies.

Adv Healthc Mater 2021 Jun 2:e2002285. Epub 2021 Jun 2.

George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

The blood-brain barrier (BBB) is a unique vascular structure that serves as a molecular transport gateway for the maintenance of brain homeostasis. Chronic disruption or breakdown of the BBB reportedly leads to neurodegenerative diseases. Nonetheless, research on human BBB pathophysiology and drug development remains highly dependent on studies using inherently different animals. Read More

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Wireless Power Transfer and Telemetry for Implantable Bioelectronics.

Adv Healthc Mater 2021 Jun 1:e2100614. Epub 2021 Jun 1.

Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.

Implantable bioelectronic devices are becoming useful and prospective solutions for various diseases owing to their ability to monitor or manipulate body functions. However, conventional implantable devices (e.g. Read More

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Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice.

Adv Healthc Mater 2021 Jun 1:e2100302. Epub 2021 Jun 1.

Department of Surgery, University of North Carolina, 4041 Burnett Womack, 101 Manning Drive, Chapel Hill, NC, 27599, USA.

Pulmonary hypertension is a highly morbid disease with no cure. Available treatments are limited by systemic adverse effects due to non-specific biodistribution. Self-assembled peptide amphiphile (PA) nanofibers are biocompatible nanomaterials that can be modified to recognize specific biological markers to provide targeted drug delivery and reduce off-target toxicity. Read More

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NIR-Responsive Ti C MXene Colloidal Solution for Curing Purulent Subcutaneous Infection through the "Nanothermal Blade" Effect.

Adv Healthc Mater 2021 May 29:e2100392. Epub 2021 May 29.

School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.

Pathogenic microorganisms' infections have always been a difficult clinical challenge and lead to serious health problems. Thus, a new strategy is urgently needed. In this study, a simple preparation method for Ti C MXene colloidal solution is proposed. Read More

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Mg Biodegradation Mechanism Deduced from the Local Surface Environment under Simulated Physiological Conditions.

Adv Healthc Mater 2021 May 29:e2100053. Epub 2021 May 29.

Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, 21502, Germany.

Although certified magnesium-based implants are launched some years ago, the not well-defined Mg degradation mechanism under physiological conditions makes it difficult to standardize its use as a degradable biomaterial for a wide range of implant applications. Among other variables influencing the Mg degradation mechanism, monitoring the pH in the corrosive solution and, especially, at the corroding interface is important due to its direct relation with the formation and stability of the degradation products layer. The interface pH (pH at the Mg/solution interface) developed on Mg-2Ag and E11 alloys are studied in situ during immersion under dynamic conditions (1. Read More

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Flexible Electrodes for In Vivo and In Vitro Electrophysiological Signal Recording.

Adv Healthc Mater 2021 May 29:e2100646. Epub 2021 May 29.

Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.

A variety of electrophysiological signals (electrocardiography, electromyography, electroencephalography, etc.) are generated during the physiological activities of human bodies, which can be collected by electrodes and thus provide critical insights into health status or facilitate fundamental scientific research. The long-term stable and high-quality recording of electrophysiological signals is the premise for their further applications, leading to demands for flexible electrodes with similar mechanical modulus and minimized irritation to human bodies. Read More

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Effects of Protein Source on Liposome Uptake by Cells: Corona Composition and Impact of the Excess Free Proteins.

Adv Healthc Mater 2021 May 29:e2100370. Epub 2021 May 29.

Department of Nanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands.

Corona formation in biological fluids strongly affects nanomedicine interactions with cells. However, relatively less is known on additional effects from the free proteins in solution. Within this context, this study aims to gain a better understanding of nanomaterial-cell interactions in different biological fluids and, more specifically, to disentangle effects due to corona composition and those from the free proteins in solution. Read More

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Insights into Mechanism of Aβ Fibril Growth on Surface of Graphene Oxides: Oxidative Degree Matters.

Adv Healthc Mater 2021 May 29:e2100436. Epub 2021 May 29.

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, College of Chemistry and Chemical Engineering, Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology, Wuhan, 430081, P. R. China.

The filamentous β-amyloid deposition has been regarded as the hallmark pathology of Alzheimer's disease (AD). Nanomaterials such as graphene oxides (GOs) have achieved significant progress in the therapy of AD, but the molecular pathway of the growth propagation remains challenging to investigate, especially on the surfaces of materials. The thermodynamics and kinetics of fibril elongation on GO surfaces with different oxidative degrees have been investigated by a combination of in vitro experiments and simulations. Read More

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Smart Asymmetric Hydrogel with Integrated Multi-Functions of NIR-Triggered Tunable Adhesion, Self-Deformation, and Bacterial Eradication.

Adv Healthc Mater 2021 May 29:e2100784. Epub 2021 May 29.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center for Materials, Sichuan University, Chengdu, 610065, China.

Multifunctional hydrogels acting as wound dressing have received extensive attention in soft tissue repair; however, it is still a challenge to develop a non-antibiotic-dependent antibacterial hydrogel that has tunable adhesion and deformation to achieve on-demand removal. Herein, an asymmetric adhesive hydrogel with near-infrared (NIR)-triggered tunable adhesion, self-deformation, and bacterial eradication is designed. The hydrogel is prepared by the crosslinking polymerization of N-isopropylacrylamide and acrylic acid, during the sedimentation of conductive PPy-PDA nanoparticles based on the polymerization of pyrrole (Py) and dopamine (DA). Read More

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Catalytic-Enhanced Lactoferrin-Functionalized Au-Bi Se Nanodots for Parkinson's Disease Therapy via Reactive Oxygen Attenuation and Mitochondrial Protection.

Adv Healthc Mater 2021 May 29:e2100316. Epub 2021 May 29.

State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou, 510640, China.

Overexpression of reactive oxygen species in the substantia nigra pars compacta destroys dopaminergic neurons and accelerates the pathological process of Parkinson's disease (PD). In this study, a new hydrophilic nano-bioconjugate, lactoferrin (Lf)-modified Au-Bi Se nanodot (ND) for efficient PD therapy is developed. In particular, the Lf-Au-Bi Se NDs exhibit strong blood-brain barrier (BBB) permeation. Read More

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All-in-One DNA Extraction Tube for Facilitated Real-Time Detection of Infectious Pathogens.

Adv Healthc Mater 2021 May 29:e2100430. Epub 2021 May 29.

Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon, 34141, Republic of Korea.

An "all-in-one tube" platform is developed, where the genetic analysis involving DNA extraction, amplification, and detection can be performed in a single tube. The all-in-one tube consists of a polymerase chain reaction (PCR) tube in which the inner surface is conformally modified with a tertiary-amine-containing polymer to generate a strong electrostatic interaction with DNA. The all-in-one tube provides high DNA capture efficiency exceeding 80% from Escherichia coli O157: H7 pathogen at a wide range of DNA amount from 0. Read More

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Enhanced Antitumor Efficacy through an "AND gate" Reactive Oxygen-Species-Dependent pH-Responsive Nanomedicine Approach.

Adv Healthc Mater 2021 May 29:e2100304. Epub 2021 May 29.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 26, Nijmegen, 6525 GA, The Netherlands.

Anticancer drug delivery strategies are designed to take advantage of the differential chemical environment in solid tumors independently, or to high levels of reactive oxygen species (ROS) or to low pH, compared to healthy tissue. Here, the design and thorough characterization of two functionalizable "AND gate" multiresponsive (MR) block amphiphilic copolymers are reported, aimed to take full advantage of the coexistence of two chemical cues-ROS and low pH-present in the tumor microenvironment. The hydrophobic blocks contain masked pH-responsive side chains, which are exposed exclusively in response to ROS. Read More

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Recent Progress in Development of Wearable Pressure Sensors Derived from Biological Materials.

Adv Healthc Mater 2021 May 29:e2100460. Epub 2021 May 29.

Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

This review summarizes recent progress in the use of biological materials (biomaterials) in wearable pressure sensors. Biomaterials are abundant, sustainable, biocompatible, and biodegradable. Especially, many have sophisticated hierarchical structure and biological characteristics, which are attractive candidates for facile and ecologically-benign fabrication of wearable pressure sensors that are biocompatible, biodegradable, and highly sensitivity. Read More

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Sutureless Transplantation of Amniotic Membrane Using a Visible Light-Curable Protein Bioadhesive for Ocular Surface Reconstruction.

Adv Healthc Mater 2021 May 29:e2100100. Epub 2021 May 29.

Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.

The conjunctiva is a thin mucous membrane of the eye. Pterygium, a commonly appearing disease on the ocular surface, requires surgery to excise the conjunctiva to prevent visual deterioration. Recently, transplantation of the amniotic membrane (AM), which is the innermost membrane of the placenta, has been highlighted as an efficient method to cure conjunctiva defects because of its advantages of no side effects compared to mitomycin C treatment and not leaving additional scars on donor site compared to conjunctival autografting. Read More

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Modulation of Gastrointestinal Mucus Properties with Ionic Liquids for Drug Delivery.

Adv Healthc Mater 2021 May 29:e2002192. Epub 2021 May 29.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.

The mucus barrier lining the gastrointestinal tract poses a significant barrier to the oral delivery of macromolecular drugs. Successful approaches to overcoming this barrier have primarily focused on reducing drug and carrier interactions with mucus or disrupting the mucus layer directly. Choline-based ionic liquids (ILs) such as choline geranate and choline glycolate (CGLY) have recently been shown to be effective in enhancing the intestinal absorption of macromolecules such as insulin and immunoglobulin (IgG), respectively. Read More

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