1,911 results match your criteria Advanced Healthcare Materials[Journal]


TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease.

Adv Healthc Mater 2019 Apr 18:e1801271. Epub 2019 Apr 18.

Center for Nanotechnology in Drug Delivery and Carolina Institute for Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Extracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported. Herein, the use of macrophage-derived EVs for brain delivery of a soluble lysosomal enzyme tripeptidyl peptidase-1, TPP1, to treat a lysosomal storage disorder, Neuronal Ceroid Lipofuscinoses 2 (CLN2) or Batten disease, is investigated. Read More

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http://dx.doi.org/10.1002/adhm.201801271DOI Listing

Engineering Hydrogels beyond a Hydrated Network.

Adv Healthc Mater 2019 Apr 16:e1900038. Epub 2019 Apr 16.

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, 01006, Vitoria-Gasteiz, Spain.

In recent years, many mechanical, physical, chemical, and biochemical features of biomatrices have emerged as important properties to dictate the fates of cells. To construct chemically defined biomaterials to recapitulate various biological niches for both cell biology research and therapeutic utilities, it has become increasingly clear that a simple hydrated polymer network would not be able to provide the complex cues and signaling required for many types of cells. The researchers are facing a growing list of mechanophysical and biochemical properties, while each of them could be an important cellular trigger. Read More

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http://dx.doi.org/10.1002/adhm.201900038DOI Listing
April 2019
4.880 Impact Factor

Capping Silica Nanoparticles with Tryptophan-Mediated Cucurbit[8]uril Complex for Targeted Intracellular Drug Delivery Triggered by Tumor-Overexpressed IDO1 Enzyme.

Adv Healthc Mater 2019 Apr 16:e1900174. Epub 2019 Apr 16.

Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 210009, P. R. China.

Nanosystems responsive to tumor-specific enzymes are considered as a highly attractive approach to intracellular drug release for targeted cancer therapy. Mesoporous silica nanoparticles are capped with tryptophan-mediated cucurbit[8]uril complex with Fe O to minimize the premature drug leakage while being able to deliver the payload on demand at the target tissue. The supramolecular interaction between tryptophan and cucurbit[8]uril is disrupted in the presence of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme (abundant in the tumor intracellular microenvironment), which catalyzes the metabolism of tryptophan into N-formylkynurenine, resulting in the disassembly of the "gate-keeper" of the nanocarriers and intracellular release of therapeutics exclusively in tumor cells. Read More

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http://dx.doi.org/10.1002/adhm.201900174DOI Listing

P-Glycoprotein Antibody Decorated Porous Hydrogel Particles for Capture and Release of Drug-Resistant Tumor Cells.

Adv Healthc Mater 2019 Apr 15:e1900136. Epub 2019 Apr 15.

Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.

Multidrug resistance is one of the leading causes of chemotherapy failure in cancer patients. Early detection and capture of drug-resistant tumor cells can facilitate the monitoring of the therapy process and improve the prognosis of patients. In this study, novel P-glycoprotein (P-gp) antibody modified porous hydrogel particles are proposed for drug-resistant tumor cells capture. Read More

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http://dx.doi.org/10.1002/adhm.201900136DOI Listing
April 2019
1 Read

Effects of Programmed Local Delivery from a Micro/Nano-Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect.

Adv Healthc Mater 2019 Apr 15:e1900002. Epub 2019 Apr 15.

Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, P. R. China.

The two major causes for implant failure are postoperative infection and poor osteogenesis. Initial period of osteointegration is regulated by immunocytes and osteogenic-related cells resulting in inflammatory response and tissue healing. The healing phase can be influenced by various environmental factors and biological cascade effect. Read More

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http://dx.doi.org/10.1002/adhm.201900002DOI Listing

Magnetic Hydrogel with Optimally Adaptive Functions for Breast Cancer Recurrence Prevention.

Adv Healthc Mater 2019 Apr 15:e1900203. Epub 2019 Apr 15.

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, 710069, China.

Engineering biocompatible hydrogels using functional nanoparticles has attracted considerable attention because of their uniquely appealing cooperative effects that can enable multimodality imaging and treatment with improved efficacy against serious diseases. However, the effects of high-content nanoparticle dopants on the rheological properties of hydrogels frequently lead to an unsatisfactory therapeutic result, which is particularly notable in the design of magnetic hydrogel formulations for cancer therapy. Herein is reported a novel magnetic hydrogel functionalized by ferromagnetic vortex-domain iron oxide (FVIOs) with optimally adaptive functions for prevention of breast cancer recurrence. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2019002
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http://dx.doi.org/10.1002/adhm.201900203DOI Listing
April 2019
2 Reads

A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling Peptides with Antimicrobial and Regenerative Potential.

Adv Healthc Mater 2019 Apr 15:e1900167. Epub 2019 Apr 15.

Institute of Medical Microbiology, Virology and Hygiene, University Medicine Rostock, 18057, Rostock, Germany.

Periodontitis is a chronic inflammatory and tissue-destructive disease. Since the polymicrobiome in the oral cavity makes it difficult to treat, novel therapeutic strategies are required. Hydrogels based on self-assembling peptides (SAP) can be suitable candidates for periodontal therapy due to their injectability, biocompatibility, cargo-loading capacity, and tunable physicochemical and mechanical properties. Read More

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http://dx.doi.org/10.1002/adhm.201900167DOI Listing
April 2019
2 Reads

Beyond 1000 nm Emission Wavelength: Recent Advances in Organic and Inorganic Emitters for Deep-Tissue Molecular Imaging.

Adv Healthc Mater 2019 Apr 14:e1900260. Epub 2019 Apr 14.

State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.

In vivo second near-infrared (NIR-II, 1.0-1.7 µm) bioimaging , a rapidly expanding imaging tool for preclinical diagnosis and prognosis, is of great importance to afford precise dynamic actions in vivo with high spatiotemporal resolution, deeper penetration, and decreasing light absorption and scattering. Read More

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http://dx.doi.org/10.1002/adhm.201900260DOI Listing

Sustained Release of Dexamethasone from Sulfobutyl Ether β-cyclodextrin Modified Self-Assembling Peptide Nanoscaffolds in a Perinatal Rat Model of Hypoxia-Ischemia.

Adv Healthc Mater 2019 Apr 12:e1900083. Epub 2019 Apr 12.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, T6G 2V4, Canada.

Inflammation plays a critical role in the development of hypoxia-ischemia (HI) induced newborn brain damage. A localized, sustained delivery of dexamethasone (Dex) through an intracerebral injection could reduce the inflammatory response in the injured perinatal brain while avoiding unnecessary side effects. Herein, investigated using anionic sulfobutyl ether β-cyclodextrin (SBE-β-CD) to load Dex in the (RADA) nanofiber networks as a means of reducing the inflammatory response to HI injury is investigated. Read More

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http://dx.doi.org/10.1002/adhm.201900083DOI Listing
April 2019
2 Reads

Bionic Poly(γ-Glutamic Acid) Electrospun Fibrous Scaffolds for Preventing Hypertrophic Scars.

Adv Healthc Mater 2019 Apr 10:e1900123. Epub 2019 Apr 10.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China.

Hypertrophic scarring (HS) remains a great challenge in wound dressing. Although various bionic extracellular matrix (ECM) biomaterials have been designed towards HS treatment, not all biomaterials can synergize biological functions and application functions in wound repair. Bionic scar-inhibiting scaffolds, loaded with biomolecules or drugs, become promising strategies for scarless skin regeneration. Read More

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http://dx.doi.org/10.1002/adhm.201900123DOI Listing
April 2019
3 Reads

Building Blocks for Biofabricated Models.

Adv Healthc Mater 2019 Apr;8(7):e1900326

Department of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/adhm.201900326DOI Listing

Multifunctional Magnetic Nanoplatform Eliminates Cancer Stem Cells via Inhibiting the Secretion of Extracellular Heat Shock Protein 90.

Adv Healthc Mater 2019 Apr 10:e1900160. Epub 2019 Apr 10.

Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, P. R. China.

Cancer stem cells (CSCs) are responsible for malignant tumor initiation, recurrences, and metastasis. Therefore, targeting CSCs is a promising strategy for the development of cancer therapies. A big challenge for CSC-based cancer therapy is the overexpression of therapeutic stress protein, heat shock protein 90 (Hsp90), which protects CSCs from further therapeutic-induced damage, leading to the failure of treatment. Read More

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http://dx.doi.org/10.1002/adhm.201900160DOI Listing

Acid-Responsive H -Releasing 2D MgB Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy.

Adv Healthc Mater 2019 Apr 10:e1900157. Epub 2019 Apr 10.

Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Road, Nanshan District, Shenzhen, 518060, Guangdong, China.

The hydrogen molecule is recognized as a high potential to attenuate toxic side effects of chemotherapy and also enhance chemotherapeutic efficacy, and the development of a novel hydrogen-generating prodrug for facile, safe, and efficient hydrogen delivery is vitally important for combined hydrogenochemotherapy but is still challenging. Here, targeting gastric cancer, a 2D magnesium boride nanosheet (MBN) is synthesized as a new type of acid-responsive hydrogen-releasing prodrug by an ultrasound-assisted chemical etching route, which is used to realize hydrogenochemotherapy by combination of facile oral administration of polyvinylpyrrolidone (PVP)-encapsulating MBN (MBN@PVP) pills with routine intravenous injection of doxorubicin (DOX). The MBN@PVP pill has high stability in normal tissues/blood environments as well as high gastric acid-responsiveness with sustained release behavior, which matches well with its metabolism rate in the stomach in great favor of continuous and long-term hydrogen administration. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2019001
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http://dx.doi.org/10.1002/adhm.201900157DOI Listing
April 2019
2 Reads

Pretreating Mesenchymal Stem Cells with Cancer Conditioned-Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells.

Adv Healthc Mater 2019 Apr 9:e1801589. Epub 2019 Apr 9.

The Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.

Nanoghosts (NGs) are nanovesicles reconstructed from the cytoplasmic membranes of mesenchymal stem cells (MSCs). By retaining MSC membranes, the NGs retain the ability of these cells to home in on multiple tumors, laying the foundations, thereby, for the development of a targeted drug delivery platform. The susceptibility of MSCs to functional changes, following their exposure to cytokines or cancer-derived conditioned-media (CM), presents the opportunity to modify the NGs by conditioning their source cells. Read More

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http://dx.doi.org/10.1002/adhm.201801589DOI Listing

Bioprinting Laponite for Orthopedic Applications.

Adv Healthc Mater 2019 Apr 8:e1900158. Epub 2019 Apr 8.

LIMAV Interdisciplinary Laboratory for Advanced Materials, Department of Materials Engineering, UFPI-Federal University of Piauí, Teresina, PI, 64049-550, Brazil.

Bioprinting technology has emerged as an important approach to bone and cartilage tissue engineering applications, because it allows the printing of scaffolds loaded with various components, such as cells, growth factors, or drugs. In this context, the bone has a very complex architecture containing highly vascularized and calcified tissues, while cartilage is avascular and has low cellularity and few nutrients. Owing to this complexity, the repair and regeneration of these tissues are highly challenging. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2019001
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http://dx.doi.org/10.1002/adhm.201900158DOI Listing
April 2019
3 Reads
4.880 Impact Factor

Drug Delivery Strategies for the Treatment of Metabolic Diseases.

Adv Healthc Mater 2019 Apr 8:e1801655. Epub 2019 Apr 8.

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Metabolic diseases occur when normal metabolic processes are disrupted in the human body, which can be congenital or acquired. The incidence of metabolic diseases worldwide has reached epidemic proportions. So far, various methods including systemic drug therapy and surgery are exploited to prevent and treat metabolic diseases. Read More

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http://dx.doi.org/10.1002/adhm.201801655DOI Listing

Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications.

Adv Healthc Mater 2019 Apr 8:e1801660. Epub 2019 Apr 8.

Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.

Medical implants, either passive implants for structural support or implantable devices with active electronics, have been widely used for the diagnosis and treatment of various diseases and clinical issues. These implants offer various functions, including mechanical support of biological structures in orthopedic and dental applications, continuous electrophysiological monitoring and feedback of electrical stimulation in neuronal and cardiac applications, and controlled drug delivery while maintaining arterial structure in drug-eluting stents. Although these implants exhibit long-term biocompatibility, surgery for their retrieval is often required, which imposes physical, biological, and economical burdens on the patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2018016
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http://dx.doi.org/10.1002/adhm.201801660DOI Listing
April 2019
5 Reads

Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core-Shell Nanowires.

Adv Healthc Mater 2019 Apr 4:e1900130. Epub 2019 Apr 4.

Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka 8-1, Ibaraki, Osaka, 567-0047, Japan.

Neural interfaces enabling light transmittance rely on optogenetics to control and monitor specific neural activity, thereby facilitating deeper understanding of intractable diseases. This study reports the material strategy underlying an optogenetic neural interface comprising stretchable and transparent conductive tracks and capable of demonstrating high biocompatibility after long-term (5-month) implantation. Ag/Au core-shell nanowires contribute toward improving track performance in terms of stretchability (<60% strain), transparency (<83%), and electrical resistance (15 Ω sq ). Read More

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http://dx.doi.org/10.1002/adhm.201900130DOI Listing
April 2019
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Density Based Characterization of Mechanical Cues on Cancer Cells Using Magnetic Levitation.

Adv Healthc Mater 2019 Apr 4:e1801517. Epub 2019 Apr 4.

Radiology Department, Canary Center for Early Cancer Detection, Stanford University School of Medicine, Stanford University, 3155 Porter Driver, Palo Alto, 94304, CA, USA.

Extracellular matrix (ECM) stiffness is correlated to malignancy and invasiveness of cancer cells. Although the mechanism of change is unclear, mechanical signals from the ECM may affect physical properties of cells such as their density profile. The current methods, such as Percoll density-gradient centrifugation, are unable to detect minute density differences. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2018015
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http://dx.doi.org/10.1002/adhm.201801517DOI Listing
April 2019
1 Read

Thermoresponsive Stiffness Softening of Hierarchically Porous Nanohybrid Membranes Promotes Niches for Mesenchymal Stem Cell Differentiation.

Adv Healthc Mater 2019 Apr 4:e1801556. Epub 2019 Apr 4.

Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, 2QG, 10 Pond St, London, NW3 2PS, UK.

Despite the attention given to the development of novel responsive implants for regenerative medicine applications, the lack of integration with the surrounding tissues and the mismatch with the dynamic mechanobiological nature of native soft tissues remain in the current products. Hierarchical porous membranes based on a poly (urea-urethane) (PUU) nanohybrid have been fabricated by thermally induced phase separation (TIPS) of the polymer solution at different temperatures. Thermoresponsive stiffness softening of the membranes through phase transition from the semicrystalline phase to rubber phase and reverse self-assembly of the quasi-random nanophase structure is characterized at body temperature near the melting point of the crystalline domains of soft segments. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2018015
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http://dx.doi.org/10.1002/adhm.201801556DOI Listing
April 2019
6 Reads

Mechanical Characterization of Human Brain Tissue and Soft Dynamic Gels Exhibiting Electromechanical Neuro-Mimicry.

Adv Healthc Mater 2019 Apr 3:e1900068. Epub 2019 Apr 3.

Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Synthetic hydrogels are an important class of materials in tissue engineering, drug delivery, and other biomedical fields. Their mechanical and electrical properties can be tuned to match those of biological tissues. In this work, hydrogels that exhibit both mechanical and electrical biomimicry are reported. Read More

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http://dx.doi.org/10.1002/adhm.201900068DOI Listing
April 2019
2 Reads

Programmable Therapeutic Nanodevices with Circular Amplification of H O in the Tumor Microenvironment for Synergistic Cancer Therapy.

Adv Healthc Mater 2019 Apr 3:e1801627. Epub 2019 Apr 3.

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.

Tumor microenvironment activated nanodevices have remarkable superiority to enhance therapeutic efficacy and minimize side effects, but their practical applications are dramatically reduced by the low abundance and heterogeneous distribution of specific stimuli at the tumor site. Herein, programmable vesicular nanodevices based on the triblock copolymer containing poly(ethylene glycol) (PEG) and poly(caprolactone) (PCL) with peroxalate esters (PO) as hydrogen peroxide-responsive linkage (PEG-PO-PCL-PO-PEG), are developed for co-delivery of hypoxia-activated prodrug (AQ4N) and glucose oxidase (GOD). The obtained nanodevices (PAG) can be activated by the high level of H O in tumor microenvironment to improve the permeability of membranes for glucose entrance. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2018016
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http://dx.doi.org/10.1002/adhm.201801627DOI Listing
April 2019
2 Reads

Atherosclerosis Treatment with Stimuli-Responsive Nanoagents: Recent Advances and Future Perspectives.

Adv Healthc Mater 2019 Apr 3:e1900036. Epub 2019 Apr 3.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030, China.

Atherosclerosis is the root of approximately one-third of global mortalities. Nanotechnology exhibits splendid prospects to combat atherosclerosis at the molecular level by engineering smart nanoagents with versatile functionalizations. Significant advances in nanoengineering enable nanoagents to autonomously navigate in the bloodstream, escape from biological barriers, and assemble with their nanocohort at the targeted lesion. Read More

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http://dx.doi.org/10.1002/adhm.201900036DOI Listing
April 2019
1 Read

Multifunctional Biomedical Adhesives.

Adv Healthc Mater 2019 Apr 3:e1801568. Epub 2019 Apr 3.

Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931, USA.

Currently available biomedical adhesives are mainly engineered to have one function (i.e., providing mechanical support for the repaired tissue). Read More

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http://dx.doi.org/10.1002/adhm.201801568DOI Listing
April 2019
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A Human Hematopoietic Niche Model Supporting Hematopoietic Stem and Progenitor Cells In Vitro.

Adv Healthc Mater 2019 Apr 3:e1801444. Epub 2019 Apr 3.

Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Niches in the bone marrow regulate hematopoietic stem and progenitor cell (HSPC) fate and behavior through cell-cell interactions and soluble factor secretion. The niche-HSPC crosstalk is a very complex process not completely elucidated yet. To aid further investigation of this crosstalk, a functional in vitro 3D model that closely represents the main supportive compartments of the bone marrow is developed. Read More

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http://dx.doi.org/10.1002/adhm.201801444DOI Listing
April 2019
3 Reads

Elastic 3D-Printed Hybrid Polymeric Scaffold Improves Cardiac Remodeling after Myocardial Infarction.

Adv Healthc Mater 2019 Apr 2:e1900065. Epub 2019 Apr 2.

Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, P. R. China.

Myocardial remodeling, including ventricular dilation and wall thinning, is an important pathological process caused by myocardial infarction (MI). To intervene in this pathological process, a new type of cardiac scaffold composed of a thermoset (poly-[glycerol sebacate], PGS) and a thermoplastic (poly-[ε-caprolactone], PCL) is directly printed by employing fused deposition modeling 3D-printing technology. The PGS-PCL scaffold possesses stacked construction with regular crisscrossed filaments and interconnected micropores and exhibits superior mechanical properties. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2019000
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http://dx.doi.org/10.1002/adhm.201900065DOI Listing
April 2019
3 Reads
4.880 Impact Factor

Conjugated Polymers in Bioelectronics: Addressing the Interface Challenge.

Adv Healthc Mater 2019 Apr 3:e1900053. Epub 2019 Apr 3.

School of Materials Science and Engineering UNSW Sydney, Sydney, New South Wales, 2052, Australia.

Conjugated polymers are the material of choice for organic bioelectronic interfaces as they combine mechanical flexibility with electric and ionic conductivity. Their attractive properties are largely demonstrated in vitro, while the in vivo applications are limited to the coating of inorganic electrodes, where they are used to improve the intimate electronic contact between the device and the tissue. However, there has not been a commensurate rise in the in vivo applications of entirely organic implantable electronic devices based on conjugated polymers. Read More

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http://dx.doi.org/10.1002/adhm.201900053DOI Listing

Heparin-Conjugated Decellularized Bone Particles Promote Enhanced Osteogenic Signaling of PDGF-BB to Adipose-Derived Stem Cells in Tissue Engineered Bone Grafts.

Adv Healthc Mater 2019 Apr 3:e1801565. Epub 2019 Apr 3.

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Adipose-derived stem cells (ASCs) are a promising cell source for regenerating critical-sized craniofacial bone defects, but their clinical use is limited due to the supraphysiological levels of bone morphogenetic protein-2 required to induce bone formation in large grafts. It has been recently reported that platelet-derived growth factor-BB (PDGF) directly enhances the osteogenesis of ASCs when applied at physiological concentrations. In this study, a biomimetic delivery system that tethers PDGF to decellularized bone matrix (DCB) is developed to enhance osteogenic signaling in bone grafts by colocalizing PDGF-extracellular matrix cues. Read More

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http://dx.doi.org/10.1002/adhm.201801565DOI Listing
April 2019
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Enhanced Neurite Outgrowth on a Multiblock Conductive Nerve Scaffold with Self-Powered Electrical Stimulation.

Adv Healthc Mater 2019 Apr 3:e1900127. Epub 2019 Apr 3.

Research Center for BioEngineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, China.

Electrical stimulation (ES) is widely applied to promote nerve regeneration. Currently, metal needles are used to exert external ES, which may cause pain and risk of infection. In this work, a multiblock conductive nerve scaffold with self-powered ES by the consumption of glucose and oxygen is prepared. Read More

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http://dx.doi.org/10.1002/adhm.201900127DOI Listing
April 2019
6 Reads

Optimized Bioactive Glass: the Quest for the Bony Graft.

Adv Healthc Mater 2019 Apr 3:e1801542. Epub 2019 Apr 3.

INRA, UMR 1019, UNH, CRNH Auvergne, F-63009 Clermont-Ferrand, France.

Technological advances have provided surgeons with a wide range of biomaterials. Yet improvements are still to be made, especially for large bone defect treatment. Biomaterial scaffolds represent a promising alternative to autologous bone grafts but in spite of the numerous studies carried out on this subject, no biomaterial scaffold is yet completely satisfying. Read More

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http://dx.doi.org/10.1002/adhm.201801542DOI Listing
April 2019
1 Read

Nontoxic Carbon Quantum Dots/g-C N for Efficient Photocatalytic Inactivation of Staphylococcus aureus under Visible Light.

Adv Healthc Mater 2019 Apr 2:e1801534. Epub 2019 Apr 2.

Department of Infectious Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.

The widespread use of antibiotics has caused the rapid emergence of antibiotic-resistant bacterial strains and antibiotic resistance genes in the past few decades. Photocatalytic inactivation, a promising approach for the killing of pathogens, efficiently avoids the problems induced by antimicrobial drugs. However, traditional photocatalysts usually have some disadvantages, such as high costs of raw materials, ultraviolet ray excitation, and potential leaching of toxic metals. Read More

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http://dx.doi.org/10.1002/adhm.201801534DOI Listing
April 2019
2 Reads

Recent Trends in Advanced Contact Lenses.

Adv Healthc Mater 2019 Apr 2:e1801390. Epub 2019 Apr 2.

Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907-2057, USA.

Exploiting contact lenses for ocular drug delivery is an emerging field in the area of biomedical engineering and advanced healthcare materials. Despite all the research conducted in this area, still, new technologies are in their early stages of the development, and more work must be done in terms of clinical trials to commercialize these technologies. A great challenge in using contact lenses for drug delivery is to achieve a prolonged drug release profile within the therapeutic range for various eye-related problems and diseases. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2018013
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http://dx.doi.org/10.1002/adhm.201801390DOI Listing
April 2019
6 Reads

Nanotechnology-Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities.

Adv Healthc Mater 2019 Apr 2:e1801184. Epub 2019 Apr 2.

Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.

Obesity is a serious health issue affecting humanity on a global scale. Recognized by the American Medical Association as a chronic disease, the incidence of obesity continues to grow at an accelerating rate and obesity has become one of the major threats to human health. Excessive weight gain is tied to metabolic syndrome, which is shown to increase the risk of chronic diseases, such as heart disease and type 2 diabetes, taxing an already overburdened healthcare system and increasing mortality worldwide. Read More

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http://dx.doi.org/10.1002/adhm.201801184DOI Listing
April 2019
5 Reads

Protein-Engineered Functional Materials.

Adv Healthc Mater 2019 Apr 2:e1801374. Epub 2019 Apr 2.

Department of Chemical and Biomolecular Engineering, New York University, Tandon School of Engineering, Brooklyn, NY, 11201, USA.

Proteins are versatile macromolecules that can perform a variety of functions. In the past three decades, they have been commonly used as building blocks to generate a range of biomaterials. Owing to their flexibility, proteins can either be used alone or in combination with other functional molecules. Read More

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http://dx.doi.org/10.1002/adhm.201801374DOI Listing
April 2019
3 Reads

Biomedical Applications of DNA-Based Molecular Devices.

Adv Healthc Mater 2019 Apr 2:e1801658. Epub 2019 Apr 2.

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing, 100190, China.

Strict Watson-Crick base pairing and availability by automated synthesis have allowed deoxyribonucleic acid (DNA) molecules to be used as engineerable building blocks for constructing versatile nanostructures. In recent decades, with the development of DNA nanotechnology, a range of DNA-based dynamic molecular devices with sophisticated nanostructures have been designed and constructed. Featuring programmability and biocompatibility, the applications of DNA-based nanodevices have been extensively focused on the interfaces of biological systems. Read More

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http://dx.doi.org/10.1002/adhm.201801658DOI Listing
April 2019
1 Read

Recent Advances in Scaffold Design and Material for Vascularized Tissue-Engineered Bone Regeneration.

Adv Healthc Mater 2019 Apr 2:e1801433. Epub 2019 Apr 2.

Department of Prosthodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639, Manufacturing Bureau Road, Huangpu District, Shanghai, China.

Bone tissue is a highly vascularized tissue and concomitant development of the vascular system and mineralized matrix requires a synergistic interaction between osteogenesis and angioblasts. Several strategies have been applied to achieve vascularized tissue-engineered bone, including the addition of cytokines as well as pre-vascularization strategies and co-culture systems. However, the scaffold is another extremely important component to consider, and development of vascularized bone scaffolds remains one of the greatest challenges for engineering clinically relevant bone substitutes. Read More

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http://dx.doi.org/10.1002/adhm.201801433DOI Listing

Targeted Magnetic Resonance Imaging and Modulation of Hypoxia with Multifunctional Hyaluronic Acid-MnO Nanoparticles in Glioma.

Adv Healthc Mater 2019 Mar 28:e1900047. Epub 2019 Mar 28.

PCFM Lab and GDHPPC Lab, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, China.

Manganese dioxide (MnO )-based nanoparticles are a promising tumor microenvironment-responsive nanotheranostic carrier for targeted magnetic resonance imaging (MRI) and for alleviating tumor hypoxia. However, the complexity and potential toxicity of the present common synthesis methods limit their clinical application. Herein, multifunctional hyaluronic acid-MnO nanoparticles (HA-MnO NPs) are synthesized in a simple way by directly mixing sodium permanganate with HA aqueous solutions, which serve as both a reducing agent and a surface-coating material. Read More

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http://dx.doi.org/10.1002/adhm.201900047DOI Listing
March 2019
4 Reads

Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties.

Adv Healthc Mater 2019 Mar 25:e1801177. Epub 2019 Mar 25.

Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA.

Poly(ethylene glycol) (PEG), a linear polymer known for its "stealth" properties, is commonly used to passivate the surface of biomedical implants and devices, and it is conjugated to biologic drugs to improve their pharmacokinetics. However, its antigenicity is a growing concern. Here, the antigenicity of PEG is investigated when assembled in a poly(oligoethylene glycol) methacrylate (POEGMA) "bottlebrush" configuration on a planar surface. Read More

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http://dx.doi.org/10.1002/adhm.201801177DOI Listing
March 2019
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Surface Immobilized E-Cadherin Mimetic Peptide Regulates the Adhesion and Clustering of Epithelial Cells.

Adv Healthc Mater 2019 Mar 25:e1801384. Epub 2019 Mar 25.

Department of Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany.

Cadherin mimetic peptides are widely used in synthetic biomaterials to mimic cell-cell adhesion in cell microniches. This mimicry regulates various cell behaviors. Although the interaction between immobilized cadherin and cells is investigated in numerous studies, the exact manner of functioning of cadherin mimetic peptides is yet to be fully understood. Read More

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http://dx.doi.org/10.1002/adhm.201801384DOI Listing
March 2019
4.880 Impact Factor

Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia.

Adv Healthc Mater 2019 Mar 22:e1801350. Epub 2019 Mar 22.

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

Local anesthetics have been extensively employed to treat postoperative pain, but they generally suffer from short acting duration and potential neurotoxicity under high local concentrations, which require the controlled and sustained releasing patterns of treatment drugs. In this work, it is reported, for the first time, the construction of hollow mesoporous organosilica nanoparticles (HMONs)-based nanoplatforms for localized delivery and controlled/sustained release of loaded ropivacaine for local anesthetics, which can be repeatedly triggered by either external ultrasound irradiation or acidity triggering to release the payload, causing on-demand and long-lasting analgesia. Based on the in vivo mouse model of incision pain, the controlled and sustained release of ropivacaine achieves more than six hours of continuous analgesia, which is almost three times longer as compared to single free ropivacaine injection. Read More

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http://dx.doi.org/10.1002/adhm.201801350DOI Listing
March 2019
1 Read
4.880 Impact Factor

Novel Strategy to Accelerate Bone Regeneration of Calcium Phosphate Cement by Incorporating 3D Plotted Poly(lactic-co-glycolic acid) Network and Bioactive Wollastonite.

Adv Healthc Mater 2019 Mar 22:e1801325. Epub 2019 Mar 22.

School of Materials Science and Engineering, Key Laboratory of Biomedical Materials of Ministry of Education, South China University of Technology, Guangzhou, 510641, China.

Inefficient bone regeneration of self-hardening calcium phosphate cement (CPC) increases the demand for interconnected macropores and osteogenesis-stimulated substances. It remains a challenge to fabricate porous CPC with interconnected macropores while maintaining its advantages, such as plasticity. Herein, pastes containing CPC and wollastonite (WS) are infiltrated into a 3D plotted poly(lactic-co-glycolic acid) (PLGA) network to fabricate plastic CPC-based composite cement (PLGA/WS/CPC). Read More

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http://dx.doi.org/10.1002/adhm.201801325DOI Listing
March 2019
4 Reads

Migration and Phenotype Control of Human Dermal Fibroblasts by Electrospun Fibrous Substrates.

Adv Healthc Mater 2019 Mar 22:e1801378. Epub 2019 Mar 22.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Electrospun fibrous matrices, mimicking extracellular matrix (ECM) hierarchical structures, are potential scaffolds for wound healing. To design functional scaffolds, it is important to explore the interactions between scaffold topographic features and cellular responses, especially directional migration and phenotypic changes, which are critical functional aspects during wound healing. Here, accelerated and persistent migration of human dermal fibroblasts (HDFs) is observed on fibers with aligned orientation. Read More

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http://dx.doi.org/10.1002/adhm.201801378DOI Listing
March 2019
4 Reads

Permanent Hydrophilization and Generic Bioactivation of Melt Electrowritten Scaffolds.

Adv Healthc Mater 2019 Apr 20;8(7):e1801544. Epub 2019 Mar 20.

Department of Functional Materials for Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

Melt electrowriting (MEW) is an emerging additive manufacturing technology that direct-writes low-micron diameter fibers into 3D scaffolds with high porosities. Often, the polymers currently used for MEW are hydrophobic thermoplastics that induce unspecific protein adsorption and subsequent uncontrolled cell adhesion. Here are developed a coating strategy for MEW scaffolds based on six-arm star-shaped NCO-poly(ethylene oxide-stat-propylene oxide) (sP(EO-stat-PO)). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2018015
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http://dx.doi.org/10.1002/adhm.201801544DOI Listing
April 2019
2 Reads

Molecular Engineering: From Molecules to Medicine.

Adv Healthc Mater 2019 Mar;8(6):e1900225

Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1002/adhm.201900225DOI Listing

BTNL2-Ig Protein Attenuates Type 1 Diabetes in Non-Obese Diabetic (NOD) Mice.

Adv Healthc Mater 2019 Mar 18:e1800987. Epub 2019 Mar 18.

Department of Allied Health Sciences, University of Connecticut, Storrs, CT, 06269, USA.

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which insulin-producing β-cells are destroyed. Although butyrophilin-like 2 (BTNL2) has been shown to be a negative T cell regulator in vitro, its ability to inhibit T cell responses in vivo has not been determined. In this study, the effect of a recombinant BTNL2-IgG2a Fc (rBTNL2-Ig) fusion protein on T1D development in vivo is determined. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2018009
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http://dx.doi.org/10.1002/adhm.201800987DOI Listing
March 2019
6 Reads

A Microfluidic Tumor-on-a-Chip for Assessing Multifunctional Liposomes' Tumor Targeting and Anticancer Efficacy.

Adv Healthc Mater 2019 Mar 14:e1900015. Epub 2019 Mar 14.

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, QLD, 4072, Australia.

Two principal methods for cancer drug testing are widely used, namely, in vitro 2D cell monolayers and in vivo animal models. In vitro 2D culture systems are simple and convenient but are unable to capture the complexity of biological processes. Animal models are costly, time-consuming, and often fail to replicate human activity. Read More

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http://dx.doi.org/10.1002/adhm.201900015DOI Listing

Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies.

Adv Healthc Mater 2019 Mar 14:e1801607. Epub 2019 Mar 14.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, 3010, Australia.

Low-fouling or "stealth" particles composed of poly(ethylene glycol) (PEG) display a striking ability to evade phagocytic cell uptake. However, functionalizing them for specific targeting is challenging. To address this challenge, stealth PEG particles prepared by a mesoporous silica templating method are functionalized with bispecific antibodies (BsAbs) to obtain PEG-BsAb particles via a one-step binding strategy for cell and tumor targeting. Read More

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http://doi.wiley.com/10.1002/adhm.201801607
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http://dx.doi.org/10.1002/adhm.201801607DOI Listing
March 2019
10 Reads
4.880 Impact Factor

Bioprinting of Cell-Laden Microfiber: Can It Become a Standard Product?

Adv Healthc Mater 2019 Mar 13:e1900014. Epub 2019 Mar 13.

State Key Laboratory of Fluid Power and Mechatronic Systems and Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, College of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.

Hydrogel microfibers have many fascinating applications as microcarriers for drugs, factors, and cells, such as 3D cell culture, building micro-organoids, and transplantation therapy due to their simple structures. It is unknown whether cell-laden fiber can become a standard-use product like woundplast. Here, from the technical and practical view, the elements required for user-oriented microfibers are first discussed: i) the materials used should promote cell functionalization and be easily processed; ii) follow a manufacturing method for mass fabrication; iii) have the ability to be stored long-term and be available for immediate use. Read More

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http://dx.doi.org/10.1002/adhm.201900014DOI Listing

Designing Melittin-Graphene Hybrid Complexes for Enhanced Antibacterial Activity.

Adv Healthc Mater 2019 Mar 13:e1801521. Epub 2019 Mar 13.

Center for Soft Condensed Matter Physics and Interdisciplinary Research and School of Physical Science and Technology, Soochow University, Suzhou, 215006, P. R. China.

Antimicrobial peptides (AMPs) promise a fundamental solution to the devastating threat of drug-resistant bacteria. However, drawbacks of AMPs (e.g. Read More

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http://doi.wiley.com/10.1002/adhm.201801521
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http://dx.doi.org/10.1002/adhm.201801521DOI Listing
March 2019
3 Reads
4.880 Impact Factor

Functionalized DNA Hydrogels Produced by Polymerase-Catalyzed Incorporation of Non-Natural Nucleotides as a Surface Coating for Cell Culture Applications.

Adv Healthc Mater 2019 Mar 12:e1900080. Epub 2019 Mar 12.

Departments of Chemistry and Biology, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstraße 10, 78464, Konstanz, Germany.

Cells from most mammalian tissues require an extracellular matrix (ECM) for attachment and proper functioning. In vitro cell cultures therefore must be supplied with an ECM that satisfies both the biological needs of cells used and the technical demands of the experimental setup. The latter include matrix functionalization for cell attachment, favorable microscopic properties, and affordable production costs. Read More

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http://dx.doi.org/10.1002/adhm.201900080DOI Listing