2,294 results match your criteria Advanced Healthcare Materials[Journal]


Artificial Intelligence and Machine Learning in Computational Nanotoxicology: Unlocking and Empowering Nanomedicine.

Adv Healthc Mater 2020 Jul 6:e1901862. Epub 2020 Jul 6.

Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, Berlin, 10589, Germany.

Advances in nanomedicine, coupled with novel methods of creating advanced materials at the nanoscale, have opened new perspectives for the development of healthcare and medical products. Special attention must be paid toward safe design approaches for nanomaterial-based products. Recently, artificial intelligence (AI) and machine learning (ML) gifted the computational tool for enhancing and improving the simulation and modeling process for nanotoxicology and nanotherapeutics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.201901862DOI Listing

Human Oral Motion-Powered Smart Dental Implant (SDI) for In Situ Ambulatory Photo-biomodulation Therapy.

Adv Healthc Mater 2020 Jul 1:e2000658. Epub 2020 Jul 1.

Department of Electrical and Computer Engineering, Temple University, Philadelphia, PA, 19122, USA.

Peri-implant disease is an inflammatory condition affecting the soft and hard tissues surrounding a dental implant. However, current preventative methods are insufficient due to the limited bioactivity on the dental implant and poor patient compliance. Recently, photo-biomodulation (PBM) therapy that can recover and regenerate peri-implant soft tissue has attracted considerable attention in dentistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000658DOI Listing

Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity.

Adv Healthc Mater 2020 Jul 1:e2000825. Epub 2020 Jul 1.

Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, 1111 Highland Ave., WIMR 5418, Madison, WI, 53705, USA.

There is a vital need to develop in vitro models of the developing human brain to recapitulate the biological effects that toxic compounds have on the brain. To model perineural vascular plexus (PNVP) in vitro, which is a key stage in embryonic development, human embryonic stem cells (hESC)-derived endothelial cells (ECs), neural progenitor cells, and microglia (MG) with primary pericytes (PCs) in synthetic hydrogels in a custom-designed microfluidics device are cocultured. The formation of a vascular plexus that includes networks of ECs (CD31+, VE-cadherin+), MG (IBA1+), and PCs (PDGFRβ+), and an overlying neuronal layer that includes differentiated neuronal cells (βIII Tubulin+, GFAP+) and radial glia (Nestin+, Notch2NL+), are characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000825DOI Listing

An Oxidation-Enhanced Magnetic Resonance Imaging Probe for Visual and Specific Detection of Singlet Oxygen Generated in Photodynamic Cancer Therapy In Vivo.

Adv Healthc Mater 2020 Jun 30:e2000533. Epub 2020 Jun 30.

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, China.

Singlet oxygen is regarded as the primary cytotoxic agent in cancer photodynamic therapy (PDT). Despite the advances in optical methods to image singlet oxygen, it remains a challenge for in vivo application due to the limited tissue penetration depth of light. Up to date, no singlet oxygen-specific magnetic resonance imaging (MRI) probe has been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000533DOI Listing

Designer Descemet Membranes Containing PDLLA and Functionalized Gelatins as Corneal Endothelial Scaffold.

Adv Healthc Mater 2020 Jun 30:e2000760. Epub 2020 Jun 30.

Antwerp Research Group for Ocular Science (ARGOS), Translational Neurosciences, Faculty of Medicine, University of Antwerp, Wilrijk, 2610, Belgium.

Corneal blindness is the fourth leading cause of visual impairment. Of specific interest is blindness due to a dysfunctional corneal endothelium which can only be treated by transplanting healthy tissue from a deceased donor. Unfortunately, corneal supply does not meet the demand with only one donor for every 70 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000760DOI Listing

Flexible and Stretchable Temperature Sensors Fabricated Using Solution-Processable Conductive Polymer Composites.

Adv Healthc Mater 2020 Jun 30:e2000380. Epub 2020 Jun 30.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.

Accurate monitoring of physiological temperatures is important for the diagnosis and tracking of various medical conditions. This work presents the design, fabrication, and characterization of temperature sensors using conductive polymer composites (CPCs) patterned on both flexible and stretchable substrates through both drop coating and direct ink writing (DIW). These composites were formed using a high melting point biopolymer polyhydroxybutyrate (PHB) as the matrix and the graphenic nanomaterial reduced graphene oxide (rGO) as the nanofiller (from 3 to 12 wt%), resulting in a material that exhibits a temperature-dependent resistivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000380DOI Listing

DNA Hybridization Measured with Graphene Transistor Arrays.

Adv Healthc Mater 2020 Jun 30:e2000260. Epub 2020 Jun 30.

Laboratoire Nanobiophysique, ESPCI Paris, Université PSL, CNRS, Paris, 75005, France.

Arrays of field-effect transistors are fabricated from chemical vapor deposition grown graphene (GFETs) and label-free detection of DNA hybridization performed down to femtomolar concentrations. A process is developed for large-area graphene sheets, which includes a thin Al O layer, protecting the graphene from contamination during photolithographic patterning and a SiO capping for biocompatibility. It enables fabrication of high-quality transistor arrays, exhibiting stable close-to-zero Dirac point voltages under ambient conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000260DOI Listing

Scaffolds Functionalized with Matrix from Induced Pluripotent Stem Cell Fibroblasts for Diabetic Wound Healing.

Adv Healthc Mater 2020 Jun 29:e2000307. Epub 2020 Jun 29.

Royal College of Surgeons in Ireland, 123 St Stephen's Green, Saint Peter's, Dublin, D02 YN77, Ireland.

Diabetic foot ulcers (DFUs) are chronic wounds, with 20% of cases resulting in amputation, despite intervention. A recently approved tissue engineering product-a cell-free collagen-glycosaminoglycan (GAG) scaffold-demonstrates 50% success, motivating its functionalization with extracellular matrix (ECM). Induced pluripotent stem cell (iPSC) technology reprograms somatic cells into an embryonic-like state. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000307DOI Listing

Heparin-Coated Albumin Nanoparticles for Drug Combination in Targeting Inflamed Intestine.

Adv Healthc Mater 2020 Jun 29:e2000536. Epub 2020 Jun 29.

Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.

Targeting areas of inflammation offers potential therapeutic and diagnostic benefits by maximizing drug and imaging marker on-target effects while minimizing systemic exposure that can be associated with adverse side effects. This strategy is particularly beneficial in the management of inflammatory bowel disease (IBD). Here an inflammation-targeting (IT) approach based on heparin-coated human serum albumin nanoparticles (HEP-HSA NPs) that utilize the increased intestinal permeability and changes in electrostatic interaction at the site of intestinal inflammation is described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000536DOI Listing

Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature.

Adv Healthc Mater 2020 Jun 29:e2000942. Epub 2020 Jun 29.

Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, 60208, USA.

Measurements of regional internal body temperatures can yield important information in the diagnosis of immune response-related anomalies, for precisely managing the effects of hyperthermia and hypothermia therapies and monitoring other transient body processes such as those associated with wound healing. Current approaches rely on permanent implants that require extraction surgeries after the measurements are no longer needed. Emerging classes of bioresorbable sensors eliminate the requirements for extraction, but their use of percutaneous wires for data acquisition leads to risks for infection at the suture site. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000942DOI Listing

Nanomedicine Approaches for Advanced Diagnosis and Treatment of Atherosclerosis and Related Ischemic Diseases.

Adv Healthc Mater 2020 Jun 29:e2000336. Epub 2020 Jun 29.

Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.

Cardiovascular diseases (CVDs) remain one of the major causes of mortality worldwide. In response to this and other worldwide health epidemics, nanomedicine has emerged as a rapidly evolving discipline that involves the development of innovative nanomaterials and nanotechnologies and their applications in therapy and diagnosis. Nanomedicine presents unique advantages over conventional medicines due to the superior properties intrinsic to nanoscopic therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000336DOI Listing

Scaffold-Mediated Static Transduction of T Cells for CAR-T Cell Therapy.

Adv Healthc Mater 2020 Jun 11:e2000275. Epub 2020 Jun 11.

Joint Department of Biomedical Engineering, University of North Carolina - Chapel Hill and North Carolina State University - Raleigh, 1840 Enterpreneur Way, Raleigh, NC, 27695, USA.

Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive clinical responses in patients with B-cell malignancies. Critical to the success of CAR-T cell therapies is the achievement of robust gene transfer into T cells mediated by viral vectors such as gamma-retroviral vectors. However, current methodologies of retroviral gene transfer rely on spinoculation and the use of retronectin, which may limit the implementation of cost-effective CAR-T cell therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000275DOI Listing

Polymeric Nanocarriers with Controlled Chain Flexibility Boost mRNA Delivery In Vivo through Enhanced Structural Fastening.

Adv Healthc Mater 2020 Jun 25:e2000538. Epub 2020 Jun 25.

Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

Messenger RNA (mRNA) shows high therapeutic potential, though effective delivery systems are still needed for boosting its application. Nanocarriers loading mRNA via polyion complexation with block catiomers into core-shell micellar structures are promising systems for enhancing mRNA delivery. Engineering the interaction between mRNA and catiomers through polymer design can promote the development of mRNA-loaded micelles (mRNA/m) with increased delivery efficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000538DOI Listing

Cancer Cell Invasion of Mammary Organoids with Basal-In Phenotype.

Adv Healthc Mater 2020 Jun 25:e2000810. Epub 2020 Jun 25.

Wallace H. Coulter Department of Biomedical Engineering and The Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332, USA.

This paper describes mammary organoids with a basal-in phenotype where the basement membrane is located on the interior surface of the organoid. A key materials consideration to induce this basal-in phenotype is the use of a minimal gel scaffold that the epithelial cells self-assemble around and encapsulate. When MDA-MB-231 breast cancer cells are co-cultured with epithelial cells from day 0 under these conditions, cells self-organize into patterns with distinct cancer cell populations both inside and at the periphery of the epithelial organoid. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000810DOI Listing

Bench-to-Bedside Lessons Learned: Commercialization of an Acellular Nerve Graft.

Adv Healthc Mater 2020 Jun 25:e2000174. Epub 2020 Jun 25.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.

Peripheral nerve injury can result in debilitating outcomes including loss of function and neuropathic pain. Although nerve repair research and therapeutic development are widely studied, translation of these ideas into clinical interventions has not occurred at the same rate. At the turn of this century, approaches to peripheral nerve repair have included microsurgical techniques, hollow conduits, and autologous nerve grafts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000174DOI Listing

Controlling the Release of Neurotrophin-3 and Chondroitinase ABC Enhances the Efficacy of Nerve Guidance Conduits.

Adv Healthc Mater 2020 Jun 16:e2000200. Epub 2020 Jun 16.

Department of Neurosurgery, Emory University, Atlanta, GA, 30322, USA.

Nerve guidance conduits (NGCs) have the potential to replace autografts in repairing peripheral nerve injuries, but their efficacy still needs to be improved. The efficacy of NGCs is augmented by neurotrophic factors that promote axon growth and by enzymes capable of degrading molecules that inhibit axon growth. In the current study, two types of NGCs loaded with factors (both neurotrophin-3 and chondroitinase ABC) are constructed and their abilities to repair an 8 mm gap in the rat sciatic nerve are examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000200DOI Listing

Decoupled pH- and Thermo-Responsive Injectable Chitosan/PNIPAM Hydrogel via Thiol-Ene Click Chemistry for Potential Applications in Tissue Engineering.

Adv Healthc Mater 2020 Jun 16:e2000454. Epub 2020 Jun 16.

Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Key Laboratory of Advanced Structural-Functional Integration Materials & Green Manufacturing Technology, Harbin Institute of Technology, Harbin, 150001, P. R. China.

Stimuli-responsive chitosan (CS) hydrogels exhibit great potential for drug delivery and tissue engineering; however, the structure of these stimuli-responsive CS hydrogels, such as dual pH- and thermo-responsive hydrogels, is difficult to control or needs additional crosslinking agents. Here, a new dual pH- and thermo-responsive hydrogel system is developed by combining pH-responsive C -OH allyl-modified CS (OAL-CS) with thermo-responsive poly(N-isopropylacrylamide) (PNIPAM). The thiol groups in PNIPAM and the allyl groups in OAL-CS can rapidly form crosslinking hydrogel network by "thiol-ene" click chemistry under UV irradiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000454DOI Listing

Bioactive MOFs Based Theranostic Agent for Highly Effective Combination of Multimodal Imaging and Chemo-Phototherapy.

Adv Healthc Mater 2020 Jun 16:e2000205. Epub 2020 Jun 16.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, 610064, P. R. China.

Bioactive metal-organic frameworks (bio-MOFs) built from biofunctional metal ions and linkers show a new strategy to construct multifunctional theranostic platforms. Herein, a bio-MOF is synthetized via the self-assembling of Fe ions and doxorubicin hydrochloride (DOX) molecules. Then, through a stepwise assembly strategy, another bio-MOFs structure consisting of Gd ions and 1,3,5-benzenetricarboxylic acid (H BTC) is wrapped on the surfaces of Fe-DOX nanoparticles, followed by adsorbing photosensitizer indocyanine green (ICG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000205DOI Listing
June 2020
4.880 Impact Factor

Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks.

Adv Healthc Mater 2020 Jun 16:e2000136. Epub 2020 Jun 16.

Department of Bioengineering, Beckman Institute of Advanced Science and Technology, Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Carle Foundation Hospital, 611 West Park Street, Urbana, IL, 61801, USA.

Metal-organic frameworks (MOFs) have applications in numerous fields. However, the development of MOF-based "theranostic" macroscale devices is not achieved. Here, heparin-coated biocompatible MOF/poly(ε-caprolactone) (PCL) "theranostic" stents are developed, where NH -Materials of Institute Lavoisier (MIL)-101(Fe) encapsulates and releases rapamycin (an immunosuppressive drug). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000136DOI Listing

A Magnetic Iron Oxide/Polydopamine Coating Can Improve Osteogenesis of 3D-Printed Porous Titanium Scaffolds with a Static Magnetic Field by Upregulating the TGFβ-Smads Pathway.

Adv Healthc Mater 2020 Jun 16:e2000318. Epub 2020 Jun 16.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, Beijing, 100730, P. R. China.

3D-printed porous titanium-aluminum-vanadium (Ti6Al4V, pTi) scaffolds offer surgeons a good option for the reconstruction of large bone defects, especially at the load-bearing sites. However, poor osteogenesis limits its application in clinic. In this study, a new magnetic coating is successfully fabricated by codepositing of Fe O nanoparticles and polydopamine (PDA) on the surface of 3D-printed pTi scaffolds, which enhances cell attachment, proliferation, and osteogenic differentiation of hBMSCs in vitro and new bone formation of rabbit femoral bone defects in vivo with/without a static magnetic field (SMF). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000318DOI Listing

3D Printing Silicone Elastomer for Patient-Specific Wearable Pulse Oximeter.

Adv Healthc Mater 2020 Jun 16:e1901735. Epub 2020 Jun 16.

Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA.

Commercial pulse oximeters are used clinically to measure heart rate and blood oxygen saturation and traditionally made from rigid materials. However, these devices are unsuitable for continuous monitoring due to poor fit and mechanical mismatch. Soft materials that match the elastic properties of biological tissue provide improved comfort and signal-to-noise but typically require molding to manufacture, limiting the speed and ease of customizing for patient-specific anatomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.201901735DOI Listing

Polymer-Covalent Organic Frameworks Composites for Glucose and pH Dual-Responsive Insulin Delivery in Mice.

Adv Healthc Mater 2020 Jun 16:e2000221. Epub 2020 Jun 16.

School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, 210023, China.

Glucose and pH dual-responsive insulin delivery carriers that have been validated in animal models, remain elusive and much desired. Herein, a new class of covalent organic frameworks (COFs)-based insulin delivery nanocarriers is developed by encapsulating insulin (Ins) and glucose oxidase (GOx) into COFs (COF-1 and COF-5) via both Brønsted and Lewis type (N:→B) complexations. Subsequently, polyethylene glycolated fluorescein isothiocyanate (FITC-PEG) is incorporated into the COFs via the exchange reactions between the disulfide in insulin chains and the thiol in FITC-PEG to afford a robust nano-assembly (FITC-PEG-COF@Ins-GOx). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000221DOI Listing

Electrostatic Intraperitoneal Aerosol Delivery of Nanoparticles: Proof of Concept and Preclinical Validation.

Adv Healthc Mater 2020 Jun 16:e2000655. Epub 2020 Jun 16.

Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, Ghent, 9000, Belgium.

There is an increasing interest in intraperitoneal delivery of chemotherapy as an aerosol in patients with peritoneal metastasis. The currently used technology is hampered by inhomogenous drug delivery throughout the peritoneal cavity because of gravity, drag, and inertial impaction. Addition of an electrical force to aerosol particles, exerted by an electrostatic field, can improve spatial aerosol homogeneity and enhance tissue penetration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000655DOI Listing

Antagomir-155 Attenuates Acute Cardiac Rejection Using Ultrasound Targeted Microbubbles Destruction.

Adv Healthc Mater 2020 Jun 16:e2000189. Epub 2020 Jun 16.

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.

Antagomir-155 is an artificial inhibitor of miRNA-155, which is expected to be a promising therapeutic target to attenuate acute cardiac rejection (ACR). However, its vulnerability of being degraded by endogenous nuclease and potential off-target effect make the authors seek for a more suitable way to delivery it. In attribution of efficiency and safety, ultrasound targeted microbubbles destruction (UTMD) turns out to be an appropriate method to deliver gene to target tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000189DOI Listing

3D Bioprinting of Oxygenated Cell-Laden Gelatin Methacryloyl Constructs.

Adv Healthc Mater 2020 Jun 16:e1901794. Epub 2020 Jun 16.

Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, CA, 90095, USA.

Cell survival during the early stages of transplantation and before new blood vessels formation is a major challenge in translational applications of 3D bioprinted tissues. Supplementing oxygen (O ) to transplanted cells via an O generating source such as calcium peroxide (CPO) is an attractive approach to ensure cell viability. Calcium peroxide also produces calcium hydroxide that reduces the viscosity of bioinks, which is a limiting factor for bioprinting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.201901794DOI Listing
June 2020
4.880 Impact Factor

Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery.

Adv Healthc Mater 2020 Jun 16:e2000469. Epub 2020 Jun 16.

Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China.

Plants and their extracts have been used especially in China for more than ten centuries for preventing and treating disease. However, there are only few reports describing their use in animal cell culture and tissue transplantation. In this study, onion epithelial membranes (OEM) is used as scaffolds to support cultures of a variety of cells such as fibroblasts and epithelial cells notably; they maintain the phenotypic characteristics of corneal epithelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000469DOI Listing

Targeted Heating of Mitochondria Greatly Augments Nanoparticle-Mediated Cancer Chemotherapy.

Adv Healthc Mater 2020 Jun 17:e2000181. Epub 2020 Jun 17.

Fishell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.

Cancer is the second leading cause of mortality globally. Various nanoparticles have been developed to improve the efficacy and safety of chemotherapy, photothermal therapy, and their combination for treating cancer. However, most of the existing nanoparticles are low in both subcellular precision and drug loading content (<≈5%), and the effect of targeted heating of subcellular organelles on the enhancement of chemotherapy has not been well explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000181DOI Listing

Humidity-Triggered Relaxation of Polyelectrolyte Complexes as a Robust Approach to Generate Extracellular Matrix Biomimetic Films.

Adv Healthc Mater 2020 Jun 17:e2000381. Epub 2020 Jun 17.

MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P. R. China.

Generating a biofunctional film that can mimic the extracellular matrix (ECM) in an efficient and robust technique that may have great potential for medical devices, tissue engineering, and regenerative medicines. Herein, a facile approach to generate ECM biomimetic films based on the humidity-triggered relaxation of polyelectrolyte complex (PEC) nanoparticles is reported. The poly(l-lysine) and hyaluronan are precomplexed and sprayed onto a substrate, which, via a trigger of vaporous water, can be transformed into an even and stable film. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000381DOI Listing

All-Aqueous-Processed Injectable In Situ Forming Macroporous Silk Gel Scaffolds for Minimally Invasive Intracranial and Osteological Therapies.

Adv Healthc Mater 2020 Jun 16:e2000879. Epub 2020 Jun 16.

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China.

Hydrogels are widely utilized in regenerative medicine for drug delivery and tissue repair due to their superior biocompatibility and high similarity to the extracellular matrix. For minimally invasive therapies, in situ forming gel scaffolds are desirable, but technical challenges remain to be overcome to achieve the balance between tissue-like strength and cell-sized porosity, especially for intracranial and osteological therapies. Here, a new method-inspired by the liquid crystalline spinning process in natural silk fibers-is reported for preparing injectable silk gel scaffolds with favorable preclinical efficacy and unique characteristics including 1) in situ gelling for minimally invasive surgeries, 2) controllable porosity for efficient cellular infiltration and desirable degradation, 3) resilient and tunable mechanical properties that are compatible with the modulus regime of native soft tissues, and 4) all-aqueous processing that avoids toxic solvents and enables facile loading of bioactive agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000879DOI Listing

Nucleolus-Targeted Photodynamic Anticancer Therapy Using Renal-Clearable Carbon Dots.

Adv Healthc Mater 2020 Jun 16:e2000607. Epub 2020 Jun 16.

School of Biomedical Engineering and State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, China.

Photodynamic therapy (PDT), which utilizes light excited photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. In order to further enhance PDT effect, PSs are functionalized to target specific sub-cellular organelles, but most PSs cannot target nucleolus, which is demonstrated as a more efficient and ideal site for cancer treatment. Here, an effective carbon dots (C-dots) photosensitizer with intrinsic nucleolus-targeting capability, for the first time, is synthesized, characterized, and employed for in vitro and in vivo image-guided photodynamic anticancer therapy with enhanced treatment performance at a low dose of PS and light irradiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000607DOI Listing

Nanobottles for Controlled Release and Drug Delivery.

Adv Healthc Mater 2020 Jun 16:e2000587. Epub 2020 Jun 16.

The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.

Nanobottles refer to colloidal particles with a hollow interior and a single opening in the wall. These unique features make them ideal carriers for the loading, encapsulation, release, and delivery of various types of theranostic agents in an array of biomedical applications. The hollow interior gives them a high loading capacity while the opening enables quick loading and controlled release of the payload(s). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000587DOI Listing

z-Wire: A Microscaffold That Supports Guided Tissue Assembly and Intramyocardium Delivery for Cardiac Repair.

Adv Healthc Mater 2020 Jun 16:e2000358. Epub 2020 Jun 16.

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.

Tissue engineering holds promise to replace damaged tissues for repair of vital organs in the human body. In cardiac repairs specifically, approaches are developed for intramyocardial delivery of cells and the epicardial delivery of tissue-engineered cardiac patches, providing benefit of cell localization and tissue structure, respectively. However, to improve cell retention and integration, there is a need for the intramyocardial delivery of functional tissues while preserving anisotropic muscle alignment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000358DOI Listing

Nature-Inspired Adhesive Catecholamines for Highly Concentrated Colorimetric Signal in Spatial Biomarker Labeling.

Adv Healthc Mater 2020 Jun 15:e2000540. Epub 2020 Jun 15.

Department of Emerging Materials Science, DGIST (Daegu Gyeongbuk Institute of Science and Technology), Daegu, 42988, Republic of Korea.

Colorants have been utilized for precise biomarker detection in rapid and convenient colorimetric bioassays. However, the diffusion of colorants in solution often results in poor sensitivity, which is a major obstacle to the clinical translation of current colorants. To address this issue, in the current study, a unique colorant is developed that possesses adhesiveness for concentration near the target biomarker, avoiding diffusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000540DOI Listing

Imaging of Injectable Hydrogels Delivered into Myocardium with SPECT/CT.

Adv Healthc Mater 2020 Jun 15:e2000294. Epub 2020 Jun 15.

Department of Bioengineering, University of Pennsylvania, 210 33rd Street, Philadelphia, PA, 19104, USA.

Injectable hydrogels are being widely explored for treatment after myocardial infarction (MI) through mechanical bulking or the delivery of therapeutics. Despite this interest, there have been few approaches to image hydrogels upon injection to identify their location, volume, and pattern of delivery, features that are important to understand toward clinical translation. Using a hyaluronic acid (HA) hydrogel as an example, the aim of this study is to introduce radiopacity to hydrogels by encapsulating a clinically used contrast agent (Omnipaque Iohexol, GE Healthcare) for imaging upon placement in the myocardium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000294DOI Listing

Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors.

Adv Healthc Mater 2020 Jun 16:e2000394. Epub 2020 Jun 16.

Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China.

The complexity of biological systems poses a great challenge in the development of nanotheranostic agents with enhanced therapeutic efficacies. To systematically overcome a series of barriers during in vivo administration and achieve optimal antitumor activity, nanotheranostic agents that can self-adaptively change their properties in response to certain tumor-associated signals are highly preferable. Herein, gold nanoparticles with a mixed-charge zwitterionic surface (Au-MUA-TMA) is fabricated, which can undergo pH-triggered self-assembly for promoting tumor targeting and improving photoacoustic imaging (PAI)-guided photothermal tumor ablation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000394DOI Listing

Liposomal Nanotherapy for Treatment of Atherosclerosis.

Adv Healthc Mater 2020 Jun 16:e2000465. Epub 2020 Jun 16.

Materials Science and Engineering, National University of Singapore, Singapore, 117575, Singapore.

Atherosclerosis is a chronic disease that can lead to life-threatening events such as myocardial infarction and stroke, is characterized by the build-up of lipids and immune cells within the arterial wall. It is understood that inflammation is a hallmark of atherosclerosis and can be a target for therapy. In support of this concept, an injectable nanoliposomal formulation encapsulating fluocinolone acetonide (FA), a corticosteroid, is developed that allows for drug delivery to atherosclerotic plaques while reducing the systemic exposure to off-target tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000465DOI Listing

Engineering Mono-Chalcogen Nanomaterials for Omnipotent Anticancer Applications: Progress and Challenges.

Adv Healthc Mater 2020 Jun 14:e2000273. Epub 2020 Jun 14.

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.

Belonging to the chalcogen group, the elements selenium (Se) and tellurium (Te) are located in Group VI-A of the periodic table. Zero-valent nanodimensioned Se (nano-Se) and Te (nano-Te) have displayed important biomedical applications in recent years. The past two decades have witnessed an explosion in novel cancer treatment strategies using nano-Se and nano-Te as aggressive weapons against tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000273DOI Listing

Recent Advances in Formulating and Processing Biomaterial Inks for Vat Polymerization-Based 3D Printing.

Adv Healthc Mater 2020 Jun 11:e2000156. Epub 2020 Jun 11.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.

3D printing and bioprinting have become a key component in precision medicine. They have been used toward the fabrication of medical devices with patient-specific shapes, production of engineered tissues for in vivo regeneration, and preparation of in vitro tissue models used for screening therapeutics. In particular, vat polymerization-based 3D (bio)printing as a unique strategy enables more sophisticated architectures to be rapidly built. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000156DOI Listing

Tumor Microenvironment Targeting Nano-Bio Emulsion for Synergistic Combinational X-Ray PDT with Oncolytic Bacteria Therapy.

Adv Healthc Mater 2020 Jun 11:e1901812. Epub 2020 Jun 11.

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Various cancer therapies have been developed, but tumor recurrence with incomplete tumor killing and remaining tumor cells/tissues is frequent in monotherapies. Herein, a nano-bio therapeutic emulsion formulated with multifunctional nanoscintillators and anaerobic Clostridium novyi-NT spores for synergistic image-guided combinational cancer therapy is reported. MRI visible nanoscintillators (NSs) are synthesized with a NaGdF :Tb,Ce@NaGdF core/shell structure for an image-guided X-ray photodynamic therapy (PDT) of the normoxic peripheral tumor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.201901812DOI Listing

Nano and Microparticle Emerging Strategies for Treatment of Autoimmune Diseases: Multiple Sclerosis and Type 1 Diabetes.

Adv Healthc Mater 2020 Jun 27;9(11):e2000164. Epub 2020 Apr 27.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.

Autoimmune diseases affect 10% of the world's population, and 1 in 200 people worldwide suffer from either multiple sclerosis (MS) or type 1 diabetes (T1D). While the targeted organ systems are different, MS and T1D share similarities in terms of autoreactive immune cells playing a critical role in pathogenesis. Both diseases can be managed only symptomatically without curative remission, and treatment options are limited and non-specific. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000164DOI Listing

Additive Manufacturing of a Point-of-Care "Polypill:" Fabrication of Concept Capsules of Complex Geometry with Bespoke Release against Cardiovascular Disease.

Adv Healthc Mater 2020 Jun 8:e2000236. Epub 2020 Jun 8.

Institute of Pharmaceutical Science, King's College London, 5.77 Franklin Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

Polypharmacy is often needed for the management of cardiovascular diseases and is associated with poor adherence to treatment. Hence, highly flexible and adaptable systems are in high demand to accommodate complex therapeutic regimens. A novel design approach is employed to fabricate highly modular 3D printed "polypill" capsules with bespoke release patterns for multiple drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000236DOI Listing

Special Issue: Biomaterials in Mechanobiology.

Adv Healthc Mater 2020 Apr;9(8):e2000412

Petit Institute for Bioengineering and Bioscience, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000412DOI Listing

Multifunctional STING-Activating Mn O @Au-dsDNA/DOX Nanoparticle for Antitumor Immunotherapy.

Adv Healthc Mater 2020 Jun 2:e2000064. Epub 2020 Jun 2.

College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu, 210093, China.

The promise of immunotherapy for cancer therapy has not been fully fulfilled because portions of tumors are immunosuppressive. To tackle this challenge, the initiation of immune system by stimulator of interferon genes (STING) pathway is explored and multifunctional STING-activating nanoparticles are rationally designed for synergistic antitumor therapy. The STING-activating nanoparticles have a formulation of Mn O @Au-dsDNA/DOX, where dsDNA is used to activate STING for immunotherapy and doxorubicin (DOX) is chosen as a model drug for chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000064DOI Listing

Smart Oral Administration of Polydopamine-Coated Nanodrugs for Efficient Attenuation of Radiation-Induced Gastrointestinal Syndrome.

Adv Healthc Mater 2020 Jun 2:e1901778. Epub 2020 Jun 2.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, 215123, China.

High-dose ionizing radiation can lead to death from the unrecoverable damage of the gastrointestinal tract, especially the small intestine. Until now, the lack of predilection for the small intestine and rapid clearance by digestive fluids limit the effects of conventional radioprotective formulations. Herein, an innovative radioprotective strategy is developed for attenuating gastrointestinal syndrome by smart oral administration nanodrugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.201901778DOI Listing

Injectable Functional Biomaterials for Minimally Invasive Surgery.

Adv Healthc Mater 2020 Jun 2:e2000349. Epub 2020 Jun 2.

Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Viale J.F. Kennedy 54, Mostra d'Oltremare Pad.20, Naples, 80125, Italy.

Injectable materials represent very attractive ready-to-use biomaterials for application in minimally invasive surgical procedures. It is shown that this approach to treat, for example, vertebral fracture, craniofacial defects, or tumor resection has significant clinical potential in the biomedical field. In the last four decades, calcium phosphate cements have been widely used as injectable materials for orthopedic surgery due to their excellent properties in terms of biocompatibility and osteoconductivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000349DOI Listing

Biomaterials against Bone Infection.

Adv Healthc Mater 2020 May 25:e2000310. Epub 2020 May 25.

Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, Madrid, 28040, Spain.

Chronic bone infection is considered as one of the most problematic biofilm-related infections. Its recurrent and resistant nature, high morbidity, prolonged hospitalization, and costly medical care expenses have driven the efforts of the scientific community to develop new therapies to improve the standards used today. There is great debate on the management of this kind of infection in order to establish consistent and agreed guidelines in national health systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000310DOI Listing

Photoactive Interfaces for Spatio-Temporal Guidance of Mesenchymal Stem Cell Fate.

Adv Healthc Mater 2020 May 19:e2000470. Epub 2020 May 19.

Center for Advanced Biomaterials for Healthcare, IIT@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci, 53, Napoli, 80125, Italy.

Patterned surfaces have proved effective in guiding stem cells commitment to a specific lineage by presenting highly ordered biophysical/biochemical cues at the cellmaterial interface. Their potency in controlling cell fate can be significantly empowered by encoding logic of space and time control of signal presentation. Here, azopolymeric photoactive interfaces are proposed to present/withdraw morphophysical signals to living cells using a green light trigger in a non-invasive spatio-temporal controlled way. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000470DOI Listing

Biodegradable Iodine-Labeled Microspheres: Potential Transarterial Radioembolization Biomaterial for Primary Hepatocellular Carcinoma Treatment.

Adv Healthc Mater 2020 May 19:e2000028. Epub 2020 May 19.

Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China.

Transarterial radioembolization with radionuclide-labeled microspheres is successfully used in hepatocellular carcinoma (HCC) treatment, but the non-biodegradability and rapid settlement of the microsphere material are associated with unsatisfied distribution and unable for multiple administrations. In this study, a novel biodegradable chitosan-collagen composite microsphere (CCM) with ideal settlement rate is prepared. The Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) results indicate CCMs have desirable shapes with diameters around 10 µm, and considerable biodegradability within 12 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000028DOI Listing

Cationic Peptidopolysaccharide with an Intrinsic AIE Effect for Combating Bacteria and Multicolor Imaging.

Adv Healthc Mater 2020 May 19:e2000419. Epub 2020 May 19.

School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.

An antibacterial polymer peptidopolysaccharide (COS-AMP) that integrates antibacterial and detection functions is constructed with a simple synthetic method. The COS-AMP is constructed by simulating the structure of peptidoglycan of the bacterial cell wall with chitooligosaccharide with intrinsic aggregation-induced emission (AIE) effect as the main chain, as well as a peptide polymer grafted onto its amino group. Based on the AIE effect and excitation-dependent fluorescence of COS-AMP, it is tentatively applied to multicolor imaging and quantification of bacteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000419DOI Listing
May 2020
4.880 Impact Factor

Bilayer Hydrogel Sheet-Type Intraocular Microrobot for Drug Delivery and Magnetic Nanoparticles Retrieval.

Adv Healthc Mater 2020 May 19:e2000118. Epub 2020 May 19.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, Republic of Korea.

By virtue of minimum invasiveness and driving ability using a magnetic field, drug delivery with the aid of a microrobot has an inherent potential for targeted treatment for the eye. The use of microrobots, however, has the limitation of leaving magnetic nanoparticles (MNPs) in the eye that can cause side effects. In this study, a bilayer hydrogel microrobot capable of retrieving MNPs after drug delivery is proposed that overcomes the limitations of existing microrobots. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202000118DOI Listing