3,326 results match your criteria Advanced Healthcare Materials[Journal]

Construction of Rhodamine-based AIE Photosensitizer Hydrogel with Clinical Potential for Selective Ablation of Drug-Resistant Gram-Positive Bacteria In Vivo.

Adv Healthc Mater 2022 Jun 24:e2200837. Epub 2022 Jun 24.

Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Korea.

The emergence of powerful antibiotic-resistant bacteria caused by the abuse of antibiotics has become a public health problem. Photodynamic antibacterial therapy is regarded as an innovative and promising antibacterial approach due to its minor side effects and lack of drug resistance. Nevertheless, few photosensitizers have been reported to have near-infrared (NIR) emission, the ability to rapidly discriminate bacteria, and high photodynamic antibacterial efficiency. Read More

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Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of both Cartilage and Subchondral Bone.

Adv Healthc Mater 2022 Jun 24:e2200602. Epub 2022 Jun 24.

School of Medicine, Southeast University, Nanjing, 210009, China.

Osteochondral defects are characterized by injuries to both cartilage and subchondral bone, which is a result of trauma, inflammation, or inappropriate loading. Due to the unique biological properties of subchondral bone and cartilage, developing a tissue engineering scaffold that can promote dual-lineage regeneration of cartilage and bone simultaneously remains a great challenge. In this study, we fabricated a microporous nanosilicate-reinforced enzymatically-crosslinked silk fibroin (SF) hydrogel by introducing two-dimensional montmorillonite (MMT) nanoparticles via intercalation chemistry. Read More

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Aggregation-induced Emission (AIE) and Magnetic Resonance Imaging Characteristics for Targeted and Image-guided siRNA Therapy of Hepatocellular Carcinoma.

Adv Healthc Mater 2022 Jun 24:e2200579. Epub 2022 Jun 24.

Shanghai Institute of Transplantation, Shanghai, 200127, China.

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and remains a global health challenge. Small interfering RNA (siRNA) is a promising therapeutic modality that blocks multiple disease-causing genes without impairing cell structures. However, siRNA therapeutics still have off-target proportion and lack effective quantitative analysis method in vivo. Read More

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Mesenchymal Stem Cell Exosomes Encapsulated Oral Microcapsules for Acute Colitis Treatment.

Adv Healthc Mater 2022 Jun 23:e2201105. Epub 2022 Jun 23.

Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Mesenchymal stem cells derived-exosomes (MSC-exos) exhibit an intrinsic and directed efficiency for multiple diseases, while their versatile and effective delivery to the target site is still challenge. Herein, inspired by the acids and enzymes resistant property of sealing gelatin capsules, we present novel MSC-exo-encapsulated oral microcapsules for colitis treatment. Based on a microfluidic electrospray technique, MSC-exos were first encapsulated in sodium alginate (SA) hydrogel microspheres with sustainable bioactivity. Read More

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Engineered Red Blood Cell Membrane-coating Salidroside/indocyanine Green Nanovesicles for High-efficiency Hypoxic Targeting Phototherapy of Triple Negative Breast Cancer.

Adv Healthc Mater 2022 Jun 23:e2200962. Epub 2022 Jun 23.

Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Cancer Center, Zhejiang Provincial People's Hospital Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.

Triple negative breast cancer (TNBC) presents special biological behavior and clinicopathological characteristics, and leads to a worse prognosis than other types of breast cancer. The development of an effective therapeutic method is significant to improve the survival rate of TNBC cancer patients. In this work, an engineered red blood cell membrane (RBCm)-coating salidroside/indocyanine green nanovesicle (ARISP) was successfully prepared for hypoxic targeting phototherapy of TNBC. Read More

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Textile-Integrated Liquid Metal Electrodes (TILEs) for Electrophysiological Monitoring.

Adv Healthc Mater 2022 Jun 23:e2200745. Epub 2022 Jun 23.

Dr. B. M. Li, Dr. Z. J. Farrell and Dr. C. E. Tabor, Air Force Research Laboratory, Materials and Manufacturing Directorate, Wright-Patterson AFB, Dayton, OH, 45433, USA.

Next generation textile-based wearable sensing systems will require flexibility and strength to maintain capabilities over a wide range of deformations. However, current material sets used for textile-based skin contacting electrodes lack these key properties, which hinder applications such as electrophysiological sensing. In this work, we present a facile spray coating approach to integrate liquid metal nanoparticle systems into textile form factors for conformal, flexible and robust electrodes. Read More

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Smart Compression Therapy Devices for Treatment of Venous Leg Ulcers: A Review.

Adv Healthc Mater 2022 Jun 22:e2200710. Epub 2022 Jun 22.

Tyndall National Institute, University College Cork, Cork, T12 R5CP, Ireland.

Venous leg ulcers can have significant social and economic impacts; and are generally treated by applying compression to the lower limb which aids in promoting blood return to the heart. Compression therapies commonly involve the use of passive bandages that suffer from issues associated with incorrect application; and; although automated solutions have begun to appear; these are often bulky and hinder patient mobility. Emerging microtechnologies and new materials could enable the development of "smart" compression therapy devices; which we define as those systems that use miniaturized and lightweight actuators and electronics to control the pressure applied to a limb. Read More

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Annexin V-modified platelet-biomimetic nanomedicine for targeted therapy of acute ischemic stroke.

Adv Healthc Mater 2022 Jun 16:e2200416. Epub 2022 Jun 16.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Taipa, Macau SAR, 999078, P. R. China.

Thromboembolic stroke is typically characterized by the activation of platelets, resulting in thrombus in the cerebral vascular system, leading to high morbidity and mortality globally. Intravenous thrombolysis by tissue plasminogen activator (tPA) administration within 4.5 h from the onset of symptoms is providing a standard therapeutic strategy for ischemic stroke, but this reagent simultaneously shows potential serious adverse effects, e. Read More

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Metabolic Symbiosis-Blocking Nano-combination for Tumor Vascular Normalization Treatment.

Adv Healthc Mater 2022 Jun 16:e2102724. Epub 2022 Jun 16.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, P. R. China.

The clinical anti-vascular endothelial growth factor (anti-VEGF) drugs and metronomic chemotherapy (MET) induced tumor vascular normalization treatment (TVNT) was easily antagonized by tumor microenvironment metabolic cross-talk between tumor cells and endothelial cells. To overcome this dilemma, nanodrug with the ability of endothelial cells targeted glycolysis inhibition and nanodrug with the ability of tumor cell glycolysis inhibition, anti-VEGF and MET were combined to prepare Nano-combination for TVNT. Besides blocking the metabolic cross-talk between tumor cells and endothelial cells, Nano-combination also induced extensive regulations-widely obstructing the pathways related to angiogenesis, tumor cell proliferation and immunosuppression and breaking the negative sugar-lipid-protein metabolism balance in tumor microenvironment. Read More

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Intrinsically Bioactive Manganese-Eumelanin Nanocomposites Mediated Antioxidation and Anti-Neuroinflammation for Targeted Theranostics of Traumatic Brain Injury.

Adv Healthc Mater 2022 Jun 13:e2200517. Epub 2022 Jun 13.

Department of Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Overproduced reactive oxygen species and the induced oxidative stress and neuroinflammation often result in secondary injury, which is associated with unfavorable prognosis in traumatic brain injury (TBI). Unfortunately, current medications cannot effectively ameliorate the secondary injury at traumatic sites. Here, it is reported that intrinsically bioactive multifunctional nanocomposites (ANG-MnEMNPs-Cur, AMEC) mediate antioxidation and anti-neuroinflammation for targeted TBI theranostics, which are engineered by loading the neuroprotective agent curcumin on angiopep-2 functionalized and manganese doped eumelanin-like nanoparticles. Read More

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Cytoprotection of Human Progenitor and Stem Cells through Encapsulation in Alginate Templated, Dual Crosslinked Silk and Silk-Gelatin Composite Hydrogel Microbeads.

Adv Healthc Mater 2022 Jun 10:e2200293. Epub 2022 Jun 10.

Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA.

Susceptibility of mammalian cells against harsh processing conditions limit their use in cell transplantation and tissue engineering applications. Besides modulation of the cell microenvironment, encapsulation of mammalian cells within hydrogel microbeads attract attention for cytoprotection through physical isolation of the encapsulated cells. The hydrogel formulations used for cell microencapsulation are largely dominated by ionically crosslinked alginate (Alg), which suffer from low structural stability under physiological culture conditions and poor cell-matrix interactions. Read More

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Brain Tumor Cell Membrane-Coated Lanthanide-Doped Nanoparticles for NIR-IIb Luminescence Imaging and Surgical Navigation of Glioma.

Adv Healthc Mater 2022 Jun 10:e2200521. Epub 2022 Jun 10.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.

Intraoperative visualization of the full extent of brain tumor by luminescence imaging helps to improve the degree and accuracy of brain tumor resection, thereby prolonging the survival of patients. However, the limited imaging depth and spatial resolution and the poor blood-brain barrier (BBB) permeability of most currently available luminescent probes restrict the imaging performance and surgical resection efficiency of brain tumor. Here, a brain tumor cell membrane-coated lanthanide-doped nanoparticles (CC-LnNPs) in the near-infrared-IIb window (NIR-IIb, 1500-1700 nm) is designed for brain tumor imaging and surgical navigation. Read More

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Bioengineered 3D Tissue Model of Intestine Epithelium with Oxygen Gradients to Sustain Human Gut Microbiome.

Adv Healthc Mater 2022 Jun 10:e2200447. Epub 2022 Jun 10.

Department of Biomedical Engineering, Tufts University, 4 Colby St, Medford, MA, 02155, USA.

The human gut microbiome is crucial to hosting physiology and health. Therefore, stable in vitro coculture of primary human intestinal cells with a microbiome community is essential for understanding intestinal disease progression and revealing novel therapeutic targets. Here, a three-dimensional scaffold system is presented to regenerate an in vitro human intestinal epithelium that recapitulates many functional characteristics of the native small intestines. Read More

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Non-PCR Ultrasensitive Detection of Viral RNA by a Nanoprobe-Coupling Strategy: SARS-CoV-2 as an Example.

Adv Healthc Mater 2022 Jun 9:e2200031. Epub 2022 Jun 9.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences; Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050, P. R. China.

Developing efficient and highly sensitive diagnostic techniques for early detections of pathogenic viruses such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is vitally important for preventing its widespread. However, the conventional polymerase chain reaction (PCR)-based detection features high complexity, excessive time-consumption, and labor-intensiveness, while viral protein-based detections suffer from moderate sensitivity and specificity. Here, a non-PCR but ultrasensitive viral RNA detection strategy is reported based on a facile nanoprobe-coupling strategy without enzymatic amplification, wherein PCR-induced bias and other shortcomings are successfully circumvented. Read More

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Biofabrication of Multiplexed Electrochemical Immunosensors for Simultaneous Detection of Clinical Biomarkers in Complex Fluids.

Adv Healthc Mater 2022 Jun 9:e2200589. Epub 2022 Jun 9.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.

Simultaneous detection of multiple disease biomarkers in unprocessed whole blood is considered the gold standard for accurate clinical diagnosis. Here, this study reports the development of a 4-plex electrochemical (EC) immunosensor with on-chip negative control capable of detecting a range of biomarkers in small volumes (15 µL) of complex biological fluids, including serum, plasma, and whole blood. A framework for fabricating and optimizing multiplexed sandwich immunoassays is presented that is enabled by use of EC sensor chips coated with an ultra-selective, antifouling, and nanocomposite coating. Read More

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Microfluidics Fabrication of Micrometer-Sized Hydrogels with Precisely Controlled Geometries for Biomedical Applications.

Adv Healthc Mater 2022 Jun 9:e2200846. Epub 2022 Jun 9.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, 00014, Finland.

Micrometer-sized hydrogels are cross-linked three-dimensional network matrices with high-water contents and dimensions ranging from several to hundreds of micrometers. Due to their excellent biocompatibility and capability to mimic physiological microenvironments in vivo, micrometer-sized hydrogels have attracted much attention in the biomedical engineering field. Their biological properties and applications are primarily influenced by their chemical compositions and geometries. Read More

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Enhancement of Lymphangiogenesis by Human Mesenchymal Stem Cell Sheet.

Adv Healthc Mater 2022 Jun 9:e2200464. Epub 2022 Jun 9.

Department of Biomedical Engineering, Texas A&M University, 101 Bizzell St, Emerging Technologies Building, College Station, Texas, 77843, USA.

Preparation of human mesenchymal stem cell (hMSC) suspension for lymphedema treatment relies on conventional enzymatic digestion methods, which severely disrupts cell-cell and cell-extracellular matrix (ECM) connections, and drastically impairs cell retention and engraftment after transplantation. The objective of the present study was to evaluate the ability of hMSC-secreted ECM to augment lymphangiogenesis by using an in vitro co-culturing model of hMSC sheets with lymphatic endothelial cells (LECs) and an in vivo mouse tail lymphedema model. Results demonstrated that the hMSC-secreted ECM augmented the formation of lymphatic capillary-like sturcture by a factor of 1. Read More

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A Cancer Cell Membrane-Derived Biomimetic Nanocarrier for Synergistic Photothermal/Gene Therapy by Efficient Delivery of CRISPR/Cas9 and Gold Nanorods.

Adv Healthc Mater 2022 Jun 7:e2201038. Epub 2022 Jun 7.

Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, P. R. China.

Bimodal synergistic therapy produces superadditive effect for enhanced therapeutic efficacy. However, how to efficiently and simultaneously deliver several kinds of therapeutic agents is still challenging. A cancer cell membrane-derived nanocarrier (mCas9-sGNRs) is proposed for synergistic photothermal/gene therapy (PTT/GT) by efficient delivery of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) and gold nanorods (GNRs). Read More

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Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non-Suture Tape.

Adv Healthc Mater 2022 Jun 7:e2200755. Epub 2022 Jun 7.

Department of Chemical and Biological Engineering, Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology, William Mong Institute of Nano Science and Technology, and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, P. R. China.

Diabetic patients suffer from peripheral nerve injury with slow and incomplete regeneration owing to hyperglycemia and microvascular complications. This study develops a graphene-based nerve guidance conduit by incorporating natural double network hydrogel and a neurotrophic concentration gradient with non-invasive treatment for diabetics. GelMA/silk fibroin double network hydrogel plays quadruple roles for rapid setting/curing, suitable mechanical supporting, good biocompatibility, and sustainable growth factor delivery. Read More

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An Optimally Fabricated Platform Guides Cancer-Specific Activation of Chemotherapeutic Drugs and Toxicity-Free Cancer Treatment.

Adv Healthc Mater 2022 Jun 7:e2200765. Epub 2022 Jun 7.

Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul, 136-713, Republic of Korea.

Cancer chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine, which are mostly small synthetic molecules, are still clinically useful for cancer treatment. However, despite considerable therapeutic efficacy, severe toxicity-associated problems, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and interference in the DNA replication even in normal cells, remain unresolved and a major challenge for safer and thus more widespread adoption of chemotherapy. Herein, an innovative platform is developed through beneficially integrating core peptide units into highly-ordered, stable, and flexibly guest-adaptable structure of apoferritin, which simultaneously fulfills high-capacity loading of chemotherapeutic drugs compared with the case of FDA-approved antibody-drug conjugates, efficient drug targeting to cancer cells, and cancer cell-specific drug release and activation. Read More

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Peptide-Based Cancer Vaccine Delivery via the STINGΔTM-cGAMP Complex.

Adv Healthc Mater 2022 Jun 7:e2200905. Epub 2022 Jun 7.

Koch Institute for Integrative Cancer Research, Cambridge, MA, 02139, USA.

With the advent of bioinformatic tools in efficiently predicting neo-antigens, peptide vaccines have gained tremendous attention in cancer immunotherapy. However, the delivery of peptide vaccines remains a major challenge, primarily due to ineffective transport to lymph nodes and low immunogenicity. Here, a strategy for peptide vaccine delivery is reported by first fusing the peptide to the cytosolic domain of the stimulator of interferon genes protein (STINGΔTM), then complexing the peptide-STINGΔTM protein with STING agonist 2'3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP). Read More

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Composite Superelastic Aerogel Scaffolds Containing Flexible SiO Nanofibers Promote Bone Regeneration.

Adv Healthc Mater 2022 Jun 7:e2200499. Epub 2022 Jun 7.

Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, P. R. China.

Repairing irregular-shaped bone defects poses enormous challenges. Scaffolds that can fully fit the defect site and simultaneously induce osteogenesis and angiogenesis hold great promise for bone defect healing. This study aimed to produce superelastic organic/inorganic composite aerogel scaffolds by blending silica nanofibers (SiO ) and poly (lactic acid)/gelatin (PLA/gel) nanofibers; the content of SiO nanofibers is varied from 0-60 wt% (e. Read More

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3D Bioprinted Silk-Based In Vitro Osteochondral Model for Osteoarthritis Therapeutics.

Adv Healthc Mater 2022 Jun 7:e2200209. Epub 2022 Jun 7.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.

3D bioprinting of osteochondral tissue offers unique opportunities for enabling precise pharmacological interventions in osteoarthritis (OA). The current study investigates the screening potential of anti-inflammatory drugs using bioprinted inflamed human osteochondral units. The biomimetic hierarchical geometry is bioprinted using silk-based bioinks encapsulating pre-differentiated stem cells, creating an in vitro model. Read More

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Body Temperature Enhanced Adhesive, Antibacterial, and Recyclable Ionic Hydrogel for Epidermal Electrophysiological Monitoring.

Adv Healthc Mater 2022 Jun 6:e2200653. Epub 2022 Jun 6.

CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.

Hydrogel-based epidermal electrodes attract widespread attention in health monitoring and human-machine interfaces for their good biocompatibility, skin-matched Young's modulus, and stable in situ electrophysiological recording performance. However, it is difficult to make the exact conformal attachment between skin and electrodes because of the hair, wrinkles, as well as complex, curved contours of the skin. This also results in signal distortion and large noise. Read More

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Coaxially Fabricated Dual-Drug Loading Electrospinning Fibrous Mat with Programmed Releasing Behavior to Boost Vascularized Bone Regeneration.

Adv Healthc Mater 2022 Jun 6:e2200571. Epub 2022 Jun 6.

Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, 200011, China.

In clinical treatment, the bone regeneration of critical-size defects is desiderated to be solved, and the regeneration of large bone segment defects depends on early vascularization. Therefore, overcoming insufficient vascularization in artificial bone grafts may be a promising strategy for critical-size bone regeneration. Herein, a novel dual-drug programmed releasing electrospinning fibrous mat (EFM) with a deferoxamine (DFO)-loaded shell layer and a dexamethasone (DEX)-loaded core layer is fabricated using coaxial electrospinning technology, considering the temporal sequence of vascularization and bone repair. Read More

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Engineering CpG-ASO-Pt-Loaded Macrophages ([email protected]) For Synergistic Chemo-/Gene-/Immuno-Therapy.

Adv Healthc Mater 2022 Jun 6:e2201178. Epub 2022 Jun 6.

Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical, Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.

Adoptive cell therapy by natural cells for drug delivery has achieved encouraging progress in cancer treatment over small-molecule drugs. Macrophages have a great potential in antitumor drug delivery due to their innate capability of sensing chemotactic cues and homing toward tumors. However, major challenge in current macrophage-based cell therapy is loading macrophages with adequate amounts of therapeutic, while allowing them to play a role in immunity without compromising cell functions. Read More

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Cascade Reaction of "Mn -Catechol" Triggered by H O to Integrate Firm Tumor Vessel Embolization and Hypoxic Response Relief.

Adv Healthc Mater 2022 Jun 6:e2200544. Epub 2022 Jun 6.

Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

Transcatheter arterial embolization (TAE) therapy requires firm and long-term vessel embolization without recanalization. However, firm embolization usually leads to unanticipated hypoxic response which promotes tumor recurrence and metastasis. Herein, an injectable thermosensitive hydrogel containing catechol groups and Mn (PNDM) has been developed to enhance embolization and inhibit hypoxic response utilizing augmented H O after TAE. Read More

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Inhibition of Sympathetic Activation by Delivering Calcium Channel Blockers from a 3D Printed Scaffold to Promote Bone Defect Repair.

Adv Healthc Mater 2022 Jun 6:e2200785. Epub 2022 Jun 6.

Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.

Enhancing osteogenesis by promoting neural network reconstruction and neuropeptide release is considered to be an attractive strategy for repairing of critical size bone defects. However, traumatic bone defects often activate the damaged sympathetic nervous system (SNS) in the defect area and release excessive catecholamine to hinder bone defect repair. Herein, a 3D printed scaffold loaded with the calcium channel blocker-nifedipine is proposed to reduce the concentration of catecholamine present in the bone defect region and to accelerate bone healing. Read More

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Photo-Crosslinked Antimicrobial Hydrogel Exhibiting Wound Healing Ability and Curing Infections In Vivo.

Adv Healthc Mater 2022 Jun 3:e2200536. Epub 2022 Jun 3.

Antimicrobial Research Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru, Karnataka, 560064, India.

With the increasing focus on healthcare research in the current times, therapeutic and biomaterial interventions for healing of wounds and mitigation of wound-associated infections have seen expedited progress. Conventional approaches consist of release-active gels, which demonstrate leaching of antimicrobials, such as antibiotics, metal ions, etc. However, these systems suffer from the disadvantages of burst release, reservoir exhaustion, and associated toxicity. Read More

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