296 results match your criteria Advanced Functional Materials[Journal]


Autocatalytic Delivery of Brain Tumor-targeting, Size-shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases.

Adv Funct Mater 2020 Apr 20;30(14). Epub 2020 Feb 20.

Department of Neurosurgery, Yale University, New Haven, CT 06511, USA.

Breast cancer brain metastases (BCBMs) represent a major cause of morbidity and mortality among patients with breast cancer. Chemotherapy, which is widely used to treat tumors outside of the brain, is often ineffective on BCBMs due to its inability to efficiently cross the blood-brain barrier (BBB). Although the BBB is partially disrupted in tumor lesions, it remains intact enough to prevent most therapeutics from entering the brain. Read More

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http://dx.doi.org/10.1002/adfm.201910651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241433PMC

Moldless Printing of Silicone Lenses With Embedded Nanostructured Optical Filters.

Adv Funct Mater 2020 Jan 12;30(4). Epub 2019 Nov 12.

Department of Information Engineering, University of Pisa, Via G. Caruso 16, 56122, Italy.

Optical lenses are among the oldest technological innovations (3000 years ago) and they have enabled a multitude of applications in healthcare and in our daily lives. The primary function of optical lenses has changed little over time; they serve mainly as a light-collection (e.g. Read More

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http://dx.doi.org/10.1002/adfm.201906836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202556PMC
January 2020

Viromimetic STING Agonist-Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus.

Adv Funct Mater 2019 Jul 12;29(28):1807616. Epub 2019 Apr 12.

Institute of Biomedical Sciences Academia Sinica Taipei 11529 Taiwan.

The continued threat of emerging, highly lethal infectious pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) calls for the development of novel vaccine technology that offers safe and effective prophylactic measures. Here, a novel nanoparticle vaccine is developed to deliver subunit viral antigens and STING agonists in a virus-like fashion. STING agonists are first encapsulated into capsid-like hollow polymeric nanoparticles, which show multiple favorable attributes, including a pH-responsive release profile, prominent local immune activation, and reduced systemic reactogenicity. Read More

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http://dx.doi.org/10.1002/adfm.201807616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161765PMC

Enhanced Fluorescence for Bioassembly by Environment-Switching Doping of Metal Ions.

Adv Funct Mater 2020 Mar 7;30(10). Epub 2020 Jan 7.

School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801 Tel Aviv, Israel.

The self-assembly of cyclodipeptides composed of natural aromatic amino acids into supramolecular structures of diverse morphologies with intrinsic emissions in the visible light region is demonstrated. The assembly process can be halted at the initial oligomerization by coordination with zinc ions, with the most prominent effect observed for cyclo-dihistidine (cyclo-HH). This process is mediated by attracting and pulling of the metal ions from the solvent into the peptide environment, rather than by direct interaction in the solvent as commonly accepted, thus forming an "environment-switching" doping mechanism. Read More

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http://dx.doi.org/10.1002/adfm.201909614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136075PMC

Imaging of Composite Hydrogel Scaffold Degradation Using CEST MRI and Two-Color NIR Imaging.

Adv Funct Mater 2019 Sep 8;29(36). Epub 2019 Jul 8.

Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Hydrogel scaffolding of stem cells is a promising strategy to overcome initial cell loss and manipulate cell function post-transplantation. Matrix degradation is a requirement for downstream cell differentiation and functional tissue integration, which determines therapeutic outcome. Therefore, monitoring of hydrogel degradation is essential for scaffolded cell replacement therapies. Read More

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http://dx.doi.org/10.1002/adfm.201903753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079757PMC
September 2019

Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound and F MRI Applied to In Vivo Cell Tracking.

Adv Funct Mater 2019 May 13;29(19). Epub 2019 Mar 13.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences (RIMLS), Geert Grooteplein Zuid 28, 6525 GA, Nijmegen, The Netherlands.

Ultrasound is the most commonly used clinical imaging modality. However, in applications requiring cell-labeling, the large size and short active lifetime of ultrasound contrast agents limit their longitudinal use. Here, 100 nm radius, clinically applicable, polymeric nanoparticles containing a liquid perfluorocarbon, which enhance ultrasound contrast during repeated ultrasound imaging over the course of at least 48 h, are described. Read More

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http://dx.doi.org/10.1002/adfm.201806485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056356PMC

A Melanin-Based Natural Antioxidant Defense Nanosystem for Theranostic Application in Acute Kidney Injury.

Adv Funct Mater 2019 Nov 25;29(48). Epub 2019 Sep 25.

Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.

Acute kidney injury (AKI) is frequently associated with oxidative stress and causes high mortality annually in clinics. Nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for the treatment of AKI. Herein, a novel biomedical use of the endogenous biopolymer melanin as a theranostic natural antioxidant defense nanoplatform for AKI is reported. Read More

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http://dx.doi.org/10.1002/adfm.201904833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017599PMC
November 2019

3D Printed Neural Regeneration Devices.

Adv Funct Mater 2020 Jan 8;30(1). Epub 2019 Nov 8.

Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.

Neural regeneration devices interface with the nervous system and can provide flexibility in material choice, implantation without the need for additional surgeries, and the ability to serve as guides augmented with physical, biological (e.g., cellular), and biochemical functionalities. Read More

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http://dx.doi.org/10.1002/adfm.201906237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007064PMC
January 2020

Molecular imaging in the second near-infrared window.

Adv Funct Mater 2019 Jun 22;29(25). Epub 2019 Apr 22.

Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

In the past decade, noticeable progress has been achieved regarding fluorescence imaging in the second near-infrared (NIR-II) window. Fluorescence imaging in the NIR-II window demonstrates superiorities of deep tissue penetration and high spatial and temporal resolution, which are beneficial for profiling physiological processes. Meanwhile, molecular imaging has emerged as an efficient tool to decipher biological activities on the molecular and cellular level. Read More

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http://dx.doi.org/10.1002/adfm.201900566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934177PMC

Binary Targeting of siRNA to Hematologic Cancer Cells using Layer-by-Layer Nanoparticles.

Adv Funct Mater 2019 May 27;29(20). Epub 2019 Mar 27.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Using siRNA therapeutics to treat hematologic malignancies has been unsuccessful because blood cancer cells exhibit remarkable resistance to standard transfection methods. Herein we report the successful delivery of siRNA therapeutics with a dual-targeted, layer-by-layer nanoparticle (LbL-NP). The LbL-NP protects siRNA from nucleases in the bloodstream by embedding it within polyelectrolyte layers that coat a polymeric core. Read More

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http://dx.doi.org/10.1002/adfm.201900018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910249PMC

Developing a Bright NIR-II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD-L1.

Adv Funct Mater 2018 Dec 22;28(50). Epub 2018 Oct 22.

Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

Fluorescence imaging in the second near-infrared (NIR-II) window holds impressive advantages of enhanced penetration depth and improved signal-to-noise ratio. Bright NIR-II fluorophores with renal excretion ability and low tissue accumulation are favorable for in vivo molecular imaging applications as they can render the target-mediated molecular imaging process easily distinguishable. Here, a probe (anti-PD-L1-BGP6) comprising a fluorophore (IR-BGP6) covalently bonded to the programmed cell death ligand-1 monoclonal antibody (PD-L1 mAb) for molecular imaging of immune checkpoint PD-L1 (a targeting site upregulated in various tumors for cancer imaging) in the NIR-II window is reported. Read More

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http://dx.doi.org/10.1002/adfm.201804956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907024PMC
December 2018

A Solid-State Hard Microfluidic-Nanopore Biosensor with Multilayer Fluidics and On-Chip Bioassay/Purification Chamber.

Adv Funct Mater 2018 Dec 16;28(50). Epub 2018 Oct 16.

Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston MA, 02215, USA.

Solid-state nanopores are an emerging biosensor for nucleic acid and protein characterization. For use in a clinical setting, solid-state nanopore sensing requires sample preparation and purification, fluid handling, a heating element, electrical noise insulators, and an electrical readout detector, all of which hamper its translation to a point-of-care diagnostic device. A stand-alone microfluidic-based nanopore device is described that combines a bioassay reaction/purification chamber with a solid-state nanopore sensor. Read More

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http://dx.doi.org/10.1002/adfm.201804182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800661PMC
December 2018

Biocompatible Soft Fluidic Strain and Force Sensors for Wearable Devices.

Adv Funct Mater 2019 Feb 6;29(7). Epub 2018 Dec 6.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

Fluidic soft sensors have been widely used in wearable devices for human motion capturing. However, thus far, the biocompatibility of the conductive liquid, the linearity of the sensing signal, and the hysteresis between the loading and release processes have limited the sensing quality as well as the applications of these sensors. In this paper, silicone based strain and force sensors composed of a novel biocompatible conductive liquid (potassium iodide and glycerol solution) are introduced. Read More

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http://dx.doi.org/10.1002/adfm.201807058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675035PMC
February 2019
5 Reads

Near-Infrared IIb Fluorescence Imaging of Vascular Regeneration with Dynamic Tissue Perfusion Measurement and High Spatial Resolution.

Adv Funct Mater 2018 Sep 23;28(36). Epub 2018 Jul 23.

Department of Cardiothoracic Surgery and Cardiovascular Institute, Stanford University, 300 Pasteur Drive, Stanford, CA 94305-5407, USA,

Real-time optical imaging is a promising approach for visualizing hemodynamics and vascular structure in mice with experimentally induced peripheral arterial disease (PAD). We report the application of a novel fluorescence-based all-optical imaging approach in the near-infrared IIb (NIR-IIb, 1500-1700 nm emission) window, for imaging hindlimb microvasculature and blood perfusion in a mouse model of PAD. In phantom studies, lead sulfide/cadmium sulfide (PbS/CdS) quantum dots showed better retention of image clarity, in comparison with single-walled nanotube (SWNT) NIR-IIa (1000-1400nm) dye, at varying depths of penetration. Read More

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http://dx.doi.org/10.1002/adfm.201803417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640151PMC
September 2018
3 Reads

Novel redox-responsive polymeric magnetosomes with tunable magnetic resonance property for drug release visualization and dual-modal cancer therapy.

Adv Funct Mater 2018 Aug 22;28(33). Epub 2018 Jun 22.

Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA.

Monitoring of drug release from nan by non-invasive approaches Remains very challenging. Herein we report on novel redox-responsive polymeric magnetosomes (PolyMags) with tunable magnetic resonance imaging (MRI) properties for drug release monitoring and effective dual-modal cancer therapy. The encapsulation of doxorubicin (DOX) significantly decreased PolyMags' T contrast enhancement and transverse relaxation rate R, depending on the drug loading level. Read More

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http://doi.wiley.com/10.1002/adfm.201802159
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http://dx.doi.org/10.1002/adfm.201802159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625784PMC
August 2018
3 Reads

RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition.

Adv Funct Mater 2018 Nov 9;28(48). Epub 2018 Oct 9.

Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.

RNA is a versatile biomaterial that can be used to engineer nanoassemblies for personalized treatment of various diseases. Despite promising advancements, the design of RNA nanoassemblies with minimal recognition by the immune system remains a major challenge. Here, an approach is reported to engineer RNA fibrous structures to operate as a customizable platform for efficient coordination of siRNAs and for maintaining low immunostimulation. Read More

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http://dx.doi.org/10.1002/adfm.201805959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599627PMC
November 2018
4 Reads

Programmable Acoustic Metasurfaces.

Adv Funct Mater 2019 Mar 8;29(13). Epub 2019 Feb 8.

Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.

Metasurfaces open up unprecedented potential for wave engineering using subwavelength sheets. However, a severe limitation of current acoustic metasurfaces is their poor reconfigurability to achieve distinct functions on demand. Here a programmable acoustic metasurface that contains an array of tunable subwavelength unit cells to break the limitation and realize versatile two-dimensional wave manipulation functions is reported. Read More

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http://dx.doi.org/10.1002/adfm.201808489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527353PMC
March 2019
4 Reads
11.805 Impact Factor

Photopolymerized Triazole-Based Glassy Polymer Networks with Superior Tensile Toughness.

Adv Funct Mater 2018 May 6;28(22). Epub 2018 Apr 6.

Department of Materials Science and Engineering, Monash University, Clayton, Victoria 3800, Australia.

Photopolymerization is a ubiquitous, indispensable technique widely applied in applications from coatings, inks, and adhesives to thermosetting restorative materials for medical implants, and the fabrication of complex macro-scale, microscale, and nanoscale 3D architectures via additive manufacturing. However, due to the brittleness inherent in the dominant acrylate-based photopolymerized networks, a significant need exists for higher performance resin/oligomer formulations to create tough, defect-free, mechanically ductile, thermally and chemically resistant, high modulus network polymers with rapid photocuring kinetics. This study presents densely cross-linked triazole-based glassy photopolymers capable of achieving preeminent toughness of ≈70 MJ m and 200% strain at ambient temperature, comparable to conventional tough thermoplastics. Read More

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http://dx.doi.org/10.1002/adfm.201801095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519945PMC
May 2018
19 Reads

A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides.

Adv Funct Mater 2019 Feb 11;29(8):1807357. Epub 2019 Jan 11.

School of Cellular and Molecular Medicine University of Bristol Bristol BS8 1TD UK.

Subunit vaccines use delivery platforms to present minimal antigenic components for immunization. The benefits of such systems include multivalency, self-adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self-assembling peptide cages (SAGEs) have been reported. Read More

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http://dx.doi.org/10.1002/adfm.201807357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161841PMC
February 2019

Polydopamine encapsulation of fluorescent nanodiamonds for biomedical applications.

Adv Funct Mater 2018 Aug 20;28(33). Epub 2018 Jun 20.

Laboratory of Single Molecule Biophysics, NHLBI, NIH, Bethesda, MD 20892, USA.

Fluorescent nanodiamonds (FNDs) are promising bio-imaging probes compared with other fluorescent nanomaterials such as quantum dots, dye-doped nanoparticles, and metallic nanoclusters, due to their remarkable optical properties and excellent biocompatibility. Nevertheless, they are prone to aggregation in physiological salt solutions, and modifying their surface to conjugate biologically active agents remains challenging. Here, inspired by the adhesive protein of marine mussels, we demonstrate encapsulation of FNDs within a polydopamine (PDA) shell. Read More

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http://doi.wiley.com/10.1002/adfm.201801252
Publisher Site
http://dx.doi.org/10.1002/adfm.201801252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342502PMC
August 2018
7 Reads

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury.

Adv Funct Mater 2019 Jan 13;29(4). Epub 2018 Nov 13.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.

Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy is vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. Exploring ways to attenuate I/R injury is of clinical interest for improving post-ischemic recovery. Read More

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http://dx.doi.org/10.1002/adfm.201803567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111457PMC
January 2019

Design, Fabrication, and Function of Silk-Based Nanomaterials.

Adv Funct Mater 2018 Dec 12;28(52). Epub 2018 Nov 12.

School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Animal silks are built from pure protein components and their mechanical performance, such as strength and toughness, often exceed most engineered materials. The secret to this success is their unique nanoarchitectures that are formed through the hierarchical self-assembly of silk proteins. This natural material fabrication process in sharp contrast to the production of artificial silk materials, which usually are directly constructed as bulk structures from silk fibroin (SF) molecular. Read More

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http://dx.doi.org/10.1002/adfm.201805305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241600PMC
December 2018

Integration of stiff graphene and tough silk for the design and fabrication of versatile electronic materials.

Adv Funct Mater 2018 Feb 19;28(9). Epub 2017 Dec 19.

Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

The production of structural and functional materials with enhanced mechanical properties through the integration of soft and hard components is a common approach to Nature's materials design. However, directly mimicking these optimized design routes in the lab for practical applications remains challenging. For example, graphene and silk are two materials with complementary mechanical properties that feature ultrahigh stiffness and toughness, respectively. Read More

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http://dx.doi.org/10.1002/adfm.201705291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261468PMC
February 2018
53 Reads

Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme-Induced Local Retention Properties.

Adv Funct Mater 2018 Oct 14;28(44). Epub 2018 Sep 14.

Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, 413 East 69 Street, New York, NY 10021, USA,

An effective tumoral delivery system should show minimal removal by the reticuloendothelial system (RES), promote tumor uptake and penetration, and minimize on-site clearance. This study reports the design and synthesis of advanced self-assembling peptide nanofiber precursor (NFP) analogues. The peptidic nature of NFP offers the design flexibility for on-demand customization with imaging agents and surface charges while maintaining a set size, allowing for real-time monitoring of kinetic and dynamic tumoral delivery by multimodal fluorescence/positron emission tomography/computed tomography (fluo/PET/CT) imaging, for formulation optimization. Read More

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http://doi.wiley.com/10.1002/adfm.201803969
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http://dx.doi.org/10.1002/adfm.201803969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261308PMC
October 2018
28 Reads

Tissue Models for Neurogenesis and Repair in 3D.

Adv Funct Mater 2018 Nov 10;28(48). Epub 2018 Oct 10.

Biomedical Engineering Department, Tufts University, Medford, Massachusetts 02155.

Development and maturation of vascular and neuronal tissues occurs simultaneously in utero, and are regulated by significant crosstalk. We report on the development of a 3D tissue system to model neurogenesis and recapitulate developmental signaling conditions. Human umbilical vein endothelial cells (HUVECs) were seeded inside channels within collagen gels to represent nascent vascular networks. Read More

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http://dx.doi.org/10.1002/adfm.201803822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241596PMC
November 2018

Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles.

Adv Funct Mater 2018 Jan 8;28(1). Epub 2017 Nov 8.

Stanford Cardiovascular Institute, Stanford, CA, 94305, United States.

The last decade has seen impressive progress in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) that makes them ideal tools to repair injured hearts. To achieve an optimal outcome, advanced molecular imaging methods are essential to accurately track these transplanted cells in the heart. Herein, we demonstrate for the first time that a class of photoacoustic nanoparticles (PANPs) incorporating semiconducting polymers (SPs) as contrast agents can be used in the photoacoustic imaging (PAI) of transplanted hESC-CMs in living mouse hearts. Read More

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http://doi.wiley.com/10.1002/adfm.201704939
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http://dx.doi.org/10.1002/adfm.201704939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247950PMC
January 2018
30 Reads

Electrically Controlled Neurochemical Release from Dual-Layer Conducting Polymer Films for Precise Modulation of Neural Network Activity in Rat Barrel Cortex.

Adv Funct Mater 2018 Mar 11;28(12). Epub 2017 Dec 11.

Department of Bioengineering, University of Pittsburgh, 5057 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.

Implantable microelectrode arrays (MEAs) are important tools for investigating functional neural circuits and treating neurological diseases. Precise modulation of neural activity may be achieved by controlled delivery of neurochemicals directly from coatings on MEA electrode sites. In this study, a novel dual-layer conductive polymer/acid functionalized carbon nanotube (fCNT) microelectrode coating is developed to better facilitate the loading and controlled delivery of the neurochemical 6,7-dinitroquinoxaline-2,3-dione (DNQX). Read More

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http://dx.doi.org/10.1002/adfm.201703988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242295PMC
March 2018
32 Reads

Hybrid Paper-Plastic Microchip for Flexible and High-Performance Point-of-Care Diagnostics.

Adv Funct Mater 2018 Jun 25;28(26). Epub 2018 Apr 25.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's, Hospital, Harvard Medical School, Boston, MA 02115, USA, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

A low-cost and easy-to-fabricate microchip remains a key challenge for the development of true point-of-care (POC) diagnostics. Cellulose paper and plastic are thin, light, flexible, and abundant raw materials, which make them excellent substrates for mass production of POC devices. Herein, a hybrid paper-plastic microchip (PPMC) is developed, which can be used for both single and multiplexed detection of different targets, providing flexibility in the design and fabrication of the microchip. Read More

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http://doi.wiley.com/10.1002/adfm.201707161
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http://dx.doi.org/10.1002/adfm.201707161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223320PMC
June 2018
45 Reads

Thermogelling, ABC Triblock Copolymer Platform for Resorbable Hydrogels with Tunable, Degradation-Mediated Drug Release.

Adv Funct Mater 2017 Dec 27;27(47). Epub 2017 Oct 27.

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.

Clinical application of injectable, thermoresponsive hydrogels is hindered by lack of degradability and controlled drug release. To overcome these challenges, a family of thermoresponsive, ABC triblock polymer-based hydrogels has been engineered to degrade and release drug cargo through either oxidative or hydrolytic/enzymatic mechanisms dictated by the "A" block composition. Three ABC triblock copolymers are synthesized with varying "A" blocks, including oxidation-sensitive poly(propylene sulfide), slow hydrolytically/enzymatically degradable poly(ε-caprolactone), and fast hydrolytically/enzymatically degradable poly(D,L-lactide--glycolide), forming the respective formulations PPS--PDMA--PNIPAAM (PDN), PCL--PDMA--PNIPAAM (CDN), and PLGA--PDMA--PNIPAAM (LGDN). Read More

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http://doi.wiley.com/10.1002/adfm.201704107
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http://dx.doi.org/10.1002/adfm.201704107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195316PMC
December 2017
4 Reads

Remote-Loaded Platelet Vesicles for Disease-Targeted Delivery of Therapeutics.

Adv Funct Mater 2018 May 19;28(22). Epub 2018 Apr 19.

Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

The recent emergence of biomimetic nanotechnology has facilitated the development of next-generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, we report on the remote loading of small molecule therapeutics into cholesterol-enriched platelet membrane-derived vesicles for disease-targeted delivery. Read More

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http://doi.wiley.com/10.1002/adfm.201801032
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http://dx.doi.org/10.1002/adfm.201801032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181445PMC
May 2018
47 Reads
11.800 Impact Factor

Nanoparticle-based fluoroionophore for analysis of potassium ion dynamics in 3D tissue models and .

Adv Funct Mater 2018 Feb 5;28(9). Epub 2018 Jan 5.

ABCRF, School of Biochemistry and Cell biology, University College Cork, Cork, Ireland.

The imaging of real-time fluxes of K ions in live cell with high dynamic range (5-150 mM) is of paramount importance for neuroscience and physiology of the gastrointestinal tract, kidney and other tissues. In particular, the research on high-performance deep-red fluorescent nanoparticle-based biosensors is highly anticipated. We found that BODIPY-based FI3 K-sensitive fluoroionophore encapsulated in cationic polymer RL100 nanoparticles displays unusually strong efficiency in staining of broad spectrum of cell models, such as primary neurons and intestinal organoids. Read More

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http://dx.doi.org/10.1002/adfm.201704598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157274PMC
February 2018
28 Reads

Intracellular Pathways Involved in Bone Regeneration Triggered by Recombinant Silk-silica Chimeras.

Adv Funct Mater 2018 Jul 4;28(27). Epub 2017 Sep 4.

Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.

Biomineralization at the organic-inorganic interface is critical to many biology material functions and . Recombinant silk-silica fusion peptides are organic-inorganic hybrid material systems that can be effectively used to study and control biologically-mediated mineralization due to the genetic basis of sequence control. However, to date, the mechanisms by which these functionalized silk-silica proteins trigger the differentiation of human mesenchymal stem cells (hMSCs) to osteoblasts remain unknown. Read More

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http://dx.doi.org/10.1002/adfm.201702570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101667PMC
July 2018
45 Reads

Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism.

Adv Funct Mater 2018 Aug 25;28(34):1800960. Epub 2018 Jun 25.

Department of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.

Highly pathogenic avian influenza virus (HPAIV) infections have occurred continuously and crossed the species barrier to humans, leading to fatalities. A polymerase chain reaction based molecular test is currently the most sensitive diagnostic tool for HPAIV; however, the results must be analyzed in centralized diagnosis systems by a trained individual. This requirement leads to delays in quarantine and isolation. Read More

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http://dx.doi.org/10.1002/adfm.201800960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161833PMC

Development of Citrate-based Dual-Imaging Enabled Biodegradable Electroactive Polymers.

Adv Funct Mater 2018 Aug 26;28(34). Epub 2018 Jun 26.

Department of Biomedical Engineering; Materials Research Institute; The Huck Institutes of The Life Sciences The Pennsylvania State University, University Park, PA, 16802, USA.

Increasing occurrences of degenerative diseases, defective tissues and severe cancers heighten the importance of advanced biomedical treatments, which in turn enhance the need for improved biomaterials with versatile theranostic functionalities yet using minimal design complexity. Leveraging the advantages of citrate chemistry, we developed a multifunctional citrate-based biomaterial platform with both imaging and therapeutic capabilities utilizing a facile and efficient one-pot synthesis. The resulting aniline tetramer doped biodegradable photoluminescent polymers (BPLPATs) not only possess programmable degradation profiles (<1 to >6 months) and mechanical strengths (~20 MPa to > 400 MPa), but also present a combination of intrinsic fluorescence, photoacoustic (PA) and electrical conductivity properties. Read More

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http://dx.doi.org/10.1002/adfm.201801787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777557PMC
August 2018
2 Reads

Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy.

Adv Funct Mater 2018 Apr 15;28(16). Epub 2018 Feb 15.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

The ability to produce nanotherapeutics at large-scale with high drug loading efficiency, high drug loading capacity, high stability, and high potency is critical for clinical translation. However, many nanoparticle-based therapeutics under investigation suffer from complicated synthesis, poor reproducibility, low stability, and high cost. In this work, a simple method for preparing multifunctional nanoparticles is utilized that act as both a contrast agent for magnetic resonance imaging and a photosensitizer for photodynamic therapy for the treatment of cancer. Read More

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http://dx.doi.org/10.1002/adfm.201707030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997278PMC
April 2018
13 Reads

Light-Guiding Biomaterials for Biomedical Applications.

Adv Funct Mater 2018 Jun 14;28(24). Epub 2018 Apr 14.

Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School. 65 Landsdowne Street, Cambridge, MA 02139, USA.

Optical techniques used in medical diagnosis, surgery, and therapy require efficient and flexible delivery of light from light sources to target tissues. While this need is currently fulfilled by glass and plastic optical fibers, recent emergence of biointegrated approaches, such as optogenetics and implanted devices, call for novel waveguides with certain biophysical and biocompatible properties and desirable shapes beyond what the conventional optical fibers can offer. To this end, exploratory efforts have begun to harness various transparent biomaterials to develop waveguides that can serve existing applications better and enable new applications in future photomedicine. Read More

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http://dx.doi.org/10.1002/adfm.201706635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703841PMC
June 2018
1 Read

Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction.

Adv Funct Mater 2018 May;28(21):1800618

Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ London, UK.

An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is introduced. The auxetic design gives the patch a negative Poisson's ratio, providing it with the ability to conform to the demanding mechanics of the heart. The conductivity allows the patch to interface with electroresponsive tissues such as the heart. Read More

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http://dx.doi.org/10.1002/adfm.201800618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985945PMC
May 2018
33 Reads

A Materials Roadmap to Functional Neural Interface Design.

Adv Funct Mater 2018 Mar 19;28(12). Epub 2017 Jul 19.

Department of Bioengineering, Center for the Basis of Neural Cognition, McGowan Institute of Regenerative Medicine, NeuroTech Center, University of Pittsburgh Brain Institute, Center for Neuroscience at the University of Pittsburgh, University of Pittsburgh, 208 Center for Biotechnology, 300 Technology Dr., Pittsburgh, PA 15219, United States.

Advancement in neurotechnologies for electrophysiology, neurochemical sensing, neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain while enabling treatments, cures, and preventative measures for a variety of neurological disorders. The grand challenge in neural interface engineering is to seamlessly integrate the interface between neurobiology and engineered technology, to record from and modulate neurons over chronic timescales. However, the biological inflammatory response to implants, neural degeneration, and long-term material stability diminish the quality of interface overtime. Read More

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http://dx.doi.org/10.1002/adfm.201701269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963731PMC
March 2018
4 Reads

Nanoformulation of Brain-Derived Neurotrophic Factor with Target Receptor-Triggered-Release in the Central Nervous System.

Adv Funct Mater 2018 Feb 7;28(6). Epub 2017 Dec 7.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7362, USA.

Brain-derived neurotrophic factor (BDNF) is identified as a potent neuroprotective and neuroregenerative agent for many neurological diseases. Regrettably, its delivery to the brain is hampered by poor serum stability and rapid brain clearance. Here, a novel nanoformulation is reported composed of a bio-compatible polymer, poly(ethylene glycol)--poly(L-glutamic acid) (PEG-PLE), that hosts the BDNF molecule in a nanoscale complex, termed here Nano-BDNF. Read More

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http://doi.wiley.com/10.1002/adfm.201703982
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http://dx.doi.org/10.1002/adfm.201703982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958903PMC
February 2018
33 Reads

Functionally Graded, Bone- and Tendon-Like Polyurethane for Rotator Cuff Repair.

Adv Funct Mater 2018 May 30;28(20). Epub 2018 Mar 30.

Department of Orthopaedic Surgery Stanford University 300 Pasteur Drive, Stanford, CA 94305, USA.

Critical considerations in engineering biomaterials for rotator cuff repair include bone-tendon-like mechanical properties to support physiological loading and biophysicochemical attributes that stabilize the repair site over the long-term. In this study, UV-crosslinkable polyurethane based on quadrol (Q), hexamethylene diisocyante (H), and methacrylic anhydride (M; QHM polymers), which are free of solvent, catalyst, and photoinitiator, is developed. Mechanical characterization studies demonstrate that QHM polymers possesses phototunable bone- and tendon-like tensile and compressive properties (12-74 MPa tensile strength, 0. Read More

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http://dx.doi.org/10.1002/adfm.201707107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959293PMC
May 2018
38 Reads
11.800 Impact Factor

Targeted Delivery of CRISPR/Cas9-Mediated Cancer Gene Therapy via Liposome-Templated Hydrogel Nanoparticles.

Adv Funct Mater 2017 Dec 16;27(46). Epub 2017 Oct 16.

Department of Neurosurgery, Yale University, New Haven, CT 06510, USA.

Due to its simplicity, versatility, and high efficiency, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology has emerged as one of the most promising approaches for treatment of a variety of genetic diseases, including human cancers. However, further translation of CRISPR/Cas9 for cancer gene therapy requires development of safe approaches for efficient, highly specific delivery of both Cas9 and single guide RNA to tumors. Here, novel core-shell nanostructure, liposome-templated hydrogel nanoparticles (LHNPs) that are optimized for efficient codelivery of Cas9 protein and nucleic acids is reported. Read More

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http://dx.doi.org/10.1002/adfm.201703036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939593PMC
December 2017
20 Reads

Coding cell micropatterns through peptide inkjet printing for arbitrary biomineralized architectures.

Adv Funct Mater 2018 May 25;28(19). Epub 2018 Mar 25.

Department of Biomedical Engineering, Tufts University, MA 02155, USA.

Well-designed micropatterns present in native tissues and organs involve changes in extracellular matrix compositions, cell types and mechanical properties to reflect complex biological functions. However, the design and fabrication of these micropatterns to meet task-specific biomedical applications remains a challenge. A design strategy to code and synthesize functional micropatterns is presented to engineer cell alignment through the integration of aqueous-peptide inkjet printing and site-specific biomineralization. Read More

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http://dx.doi.org/10.1002/adfm.201800228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241601PMC

Actively Targeted Deep Tissue Imaging and Photothermal-Chemo Therapy of Breast Cancer by Antibody-Functionalized Drug-Loaded X-Ray-Responsive Bismuth Sulfide@Mesoporous Silica Core-Shell Nanoparticles.

Adv Funct Mater 2018 Jan 11;28(5). Epub 2017 Dec 11.

Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK 73072, USA.

A theranostic platform combining synergistic therapy and real-time imaging attracts enormous attention but still faces great challenges, such as tedious modifications and lack of efficient accumulation in tumor. Here, a novel type of theranostic agent, bismuth sulfide@mesoporous silica (BiS@ mPS) core-shell nanoparticles (NPs), for targeted image-guided therapy of human epidermal growth factor receptor-2 (HER-2) positive breast cancer is developed. To generate such NPs, polyvinylpyrrolidone decorated rod-like BiS NPs are chemically encapsulated with a mesoporous silica (mPS) layer and loaded with an anticancer drug, doxorubicin. Read More

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http://dx.doi.org/10.1002/adfm.201704623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918278PMC
January 2018
32 Reads

Ice-Templated Protein Nanoridges Induce Bone Tissue Formation.

Adv Funct Mater 2017 Nov 5;27(44). Epub 2017 Oct 5.

Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK 73019-5300, USA.

Little is known about the role of biocompatible protein nanoridges in directing stem cell fate and tissue regeneration due to the difficulty in forming protein nanoridges. Here an ice-templating approach is proposed to produce semi-parallel pure silk protein nanoridges. The key to this approach is that water droplets formed in the protein films are frozen into ice crystals (removed later by sublimation), pushing the surrounding protein molecules to be assembled into nanoridges. Read More

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http://dx.doi.org/10.1002/adfm.201703726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898400PMC
November 2017
7 Reads

Fluorescent Nanomaterials for the Development of Latent Fingerprints in Forensic Sciences.

Adv Funct Mater 2017 Apr 28;27(14). Epub 2017 Feb 28.

School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.

This review presents an overview on the application of latent fingerprint development techniques in forensic sciences. At present, traditional developing methods such as powder dusting, cyanoacrylate fuming, chemical method, and small particle reagent method, have all been gradually compromised given their emerging drawbacks such as low contrast, sensitivity, and selectivity, as well as high toxicity. Recently, much attention has been paid to the use of fluorescent nanomaterials including quantum dots (QDs) and rare earth upconversion fluorescent nanomaterials (UCNMs) due to their unique optical and chemical properties. Read More

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http://dx.doi.org/10.1002/adfm.201606243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898818PMC
April 2017
5 Reads

Integration of Phase-Change Materials with Electrospun Fibers for Promoting Neurite Outgrowth under Controlled Release.

Adv Funct Mater 2018 Apr 31;28(15). Epub 2018 Jan 31.

The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.

We report a temperature-regulated system for the controlled release of nerve growth factor (NGF) to promote neurite outgrowth. The system is based upon microparticles fabricated using coaxial electrospray, with the outer solution containing a phase-change material (PCM) and the inner solution encompassing payload(s). When the temperature is kept below the melting point of the PCM, there is no release due to the extremely slow diffusion through a solid matrix. Read More

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http://dx.doi.org/10.1002/adfm.201705563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660177PMC

Multifunctional biomedical imaging in physiological and pathological conditions using a NIR-II probe.

Adv Funct Mater 2017 Jun 24;27(23). Epub 2017 Apr 24.

Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Rd, Lucas P095, Stanford, CA 94305-5484, USA.

Compared with imaging in the visible (400 - 650 nm) and near-infrared window I (NIR-I, 650 - 900 nm) regions, imaging in near-infrared window II (NIR-II, 1,000-1,700 nm) is a highly promising imaging modality with improved resolution and deeper tissue penetration. In this work, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), has been successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000. Then this novel NIR-II probe has been studied for multifunctional biological imaging. Read More

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http://dx.doi.org/10.1002/adfm.201700995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879786PMC
June 2017
8 Reads

Extended Solution Gate OFET-based Biosensor for Label-free Glial Fibrillary Acidic Protein Detection with Polyethylene Glycol-Containing Bioreceptor Layer.

Adv Funct Mater 2017 May 23;27(20). Epub 2017 Mar 23.

Department of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.

A novel organic field effect transistor (OFET) -based biosensor is described for label-free glial fibrillary acidic protein (GFAP) detection. We report the first use of an extended solution gate structure where the sensing area and the organic semiconductor are separated, and a reference electrode is not needed. Different molecular weight polyethylene glycols (PEGs) are mixed into the bio-receptor layer to help extend the Debye screening length. Read More

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http://dx.doi.org/10.1002/adfm.201606506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873605PMC
May 2017
11 Reads

Catanionic Surfactant Vesicles as a New Platform for probing Glycan-Protein Interactions.

Adv Funct Mater 2018 Mar 19;28(13). Epub 2018 Jan 19.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742.

Glycomics lags substantially behind proteomics and genomics in its ability to decipher and synthesize complex glycans. The slow progress in deciphering glycan interactions at a molecular level is in large part due to the absence of a functional system to express, on a large scale, carbohydrates of known structure, in the context of a biologically relevant assay system. Here we describe the characterization of a glycan-functionalized catanionic surfactant vesicles (CVs) as a platform for glycan synthesis, and to demonstrate that the resulting glycan-functionalized CVs can serve as a scaffold for the interrogation of protein-glycan interactions. Read More

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http://dx.doi.org/10.1002/adfm.201706215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527319PMC
March 2018
3 Reads

Bioorthogonal Strategies for Engineering Extracellular Matrices.

Adv Funct Mater 2018 Mar 19;28(11). Epub 2018 Jan 19.

Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA,

Hydrogels are commonly used as engineered extracellular matrix (ECM) mimics in applications ranging from tissue engineering to disease models. Ideal mechanisms used to crosslink ECM-mimicking hydrogels do not interfere with the biology of the system. However, most common hydrogel crosslinking chemistries exhibit some form of cross-reactivity. Read More

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http://dx.doi.org/10.1002/adfm.201706046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761700PMC