458 results match your criteria Advanced Functional Materials[Journal]

Hydrogels Containing Gradients in Vascular Density Reveal Dose-Dependent Role of Angiocrine Cues on Stem Cell Behavior.

Adv Funct Mater 2021 Dec 17;31(51). Epub 2021 Sep 17.

Dept. Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Dept. Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Dept. Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Biomaterials that replicate patterns of microenvironmental signals from the stem cell niche offer the potential to refine platforms to regulate stem cell behavior. While significant emphasis has been placed on understanding the effects of biophysical and biochemical cues on stem cell fate, vascular-derived or angiocrine cues offer an important alternative signaling axis for biomaterial-based stem cell platforms. Elucidating dose-dependent relationships between angiocrine cues and stem cell fate are largely intractable in animal models and 2D cell cultures. Read More

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December 2021

Compact Quantum-Dot Microbeads with Sub-Nanometer Emission Linewidth.

Adv Funct Mater 2021 Nov 27;31(48). Epub 2021 Aug 27.

Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA.

Fluorescent microbeads are widely used for applications in life sciences and medical diagnosis. The spectral contrast and sharpness of photoluminescence are critical in the utilities of microbeads for imaging and multiplexing. Here, we demonstrate microbeads capable of generating single-peak laser emission with a sub-nanometer linewidth. Read More

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November 2021

Conversion of 2D MXene to Multi-Low-Dimensional GerMXene Superlattice Heterostructure.

Adv Funct Mater 2022 Mar 30;32(10):2108495. Epub 2021 Nov 30.

Regenerative Medicine Program Department of Physiology and Pathophysiology Rady Faculty of Health Sciences Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre University of Manitoba Winnipeg Manitoba R2H2A6 Canada.

Integration of 2D structures into other low-dimensional materials results in the development of distinct van der Waals heterostructures (vdWHSs) with enhanced properties. However, obtaining 2D-1D-0D vdWHSs of technologically useful next generation materials, transition-metal carbide MXene and monoelemental Xene nanosheets in a single superlattice heterostructure is still challenging. Here, the fabrication of a new multidimensional superlattice heterostructure "GerMXene" from exfoliated MXT MXene and hydrogenated germanane (GeH) crystals, is reported. Read More

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Development of Fluorine-Free Tantalum Carbide MXene Hybrid Structure as a Biocompatible Material for Supercapacitor Electrodes.

Adv Funct Mater 2021 Jul 24;31(30):2100015. Epub 2021 May 24.

Regenerative Medicine Program Institute of Cardiovascular Sciences St. Boniface Hospital Research Centre Department of Physiology and Pathophysiology Rady Faculty of Health Sciences University of Manitoba Winnipeg MB R2H 0G1 Canada.

The application of nontoxic 2D transition-metal carbides (MXenes) has recently gained ground in bioelectronics. In group-4 transition metals, tantalum possesses enhanced biological and physical properties compared to other MXene counterparts. However, the application of tantalum carbide for bioelectrodes has not yet been explored. Read More

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Head on Comparison of Self- and Nano-assemblies of Gamma Peptide Nucleic Acid Amphiphiles.

Adv Funct Mater 2022 Feb 5;32(7). Epub 2021 Nov 5.

Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.

Peptide nucleic acids (PNAs) are nucleic acid analogs with superior hybridization properties and enzymatic stability than deoxyribonucleic acid (DNA). In addition to gene targeting applications, PNAs have garnered significant attention as bio-polymer due to the Watson-Crick -based molecular recognition and flexibility of synthesis. Here, we engineered PNA amphiphiles using chemically modified gamma PNA (8 mer in length) containing hydrophilic diethylene glycol units at the gamma position and covalently conjugated lauric acid (C12) as a hydrophobic moiety. Read More

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February 2022

Fabrication of Smart Tantalum Carbide MXene Quantum Dots with Intrinsic Immunomodulatory Properties for Treatment of Allograft Vasculopathy.

Adv Funct Mater 2021 Nov 8;31(46):2106786. Epub 2021 Sep 8.

Regenerative Medicine Program Department of Physiology and Pathophysiology Rady Faculty of Health Sciences University of Manitoba Winnipeg Manitoba R3E 0W2 Canada.

MXene nanomaterials have sparked significant interest among interdisciplinary researchers to tackle today's medical challenges. In particular, colloidal MXene quantum dots (MQDs) offer the high specific surface area and compositional flexibility of MXene while providing improvements to aqueous stability and material-cell interactions. The current study for the first time reports the development and application of immunoengineered tantalum-carbide (TaCT ) MQDs for in vivo treatment of transplant vasculopathy. Read More

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November 2021

Organic Semiconductor Nanotubes for Electrochemical Devices.

Adv Funct Mater 2021 Dec 30;31(49). Epub 2021 Jul 30.

Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Houston, TX 77204, USA.

Electrochemical devices that transform electrical energy to mechanical energy through an electrochemical process have numerous applications ranging from soft robotics and micropumps to autofocus microlenses and bioelectronics. To date, achievement of large deformation strains and fast response times remains a challenge for electrochemical actuator devices operating in liquid wherein drag forces restrict the actuator motion and electrode materials/structures limit the ion transportation and accumulation. We report results for electrochemical actuators, electrochemical mass transfers, and electrochemical dynamics made from organic semiconductors (OSNTs). Read More

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December 2021

Multifunctional Triboelectric Nanogenerator-enabled Structural Elements for Next Generation Civil Infrastructure Monitoring Systems.

Adv Funct Mater 2021 Nov 16;31(47). Epub 2021 Aug 16.

Department of Civil and Environmental Engineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.

There is a critical shortage in research needed to explore a new class of multifunctional structural components that respond to their environment, empower themselves and self-monitor their condition. Here, we propose the novel concept of triboelectric nanogenerator-enabled structural elements (TENG-SEs) to build the foundation for the next generation civil infrastructure systems with intrinsic sensing and energy harvesting functionalities. In order to validate the proposed concept, we develop proof-of-concept multifunctional composite rebars with built-in triboelectric nanogenerator mechanisms. Read More

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November 2021

A facile magnetic extrusion method for preparing endosome-derived vesicles for cancer drug delivery.

Adv Funct Mater 2021 Oct 20;31(44). Epub 2021 Jan 20.

Vascular Biology Program, Boston Children's Hospital, Boston, MA, United States.

To date, the scaled-up manufacturing and efficient drug loading of exosomes are two existing challenges limiting the clinical translation of exosome-based drug delivery. Herein, we developed a facile magnetic extrusion method for preparing endosome-derived vesicles, also known as exosome mimetics (EMs), which share the same biological origin and similar morphology, composition, and biofunctions with native exosomes. The high yield and consistency of this magnetic extrusion method help to overcome the manufacturing bottleneck in exosome research. Read More

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October 2021

Multimodal Label-Free Monitoring of Adipogenic Stem Cell Differentiation Using Endogenous Optical Biomarkers.

Adv Funct Mater 2021 Oct 6;31(43). Epub 2021 Aug 6.

Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.

Stem cell-based therapies carry significant promise for treating human diseases. However, clinical translation of stem cell transplants for effective treatment requires precise non-destructive evaluation of the purity of stem cells with high sensitivity (<0.001% of the number of cells). Read More

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October 2021

Customizing MRI-Compatible Multifunctional Neural Interfaces through Fiber Drawing.

Adv Funct Mater 2021 Oct 6;31(43). Epub 2021 Aug 6.

Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have prevented integrated drawing of metal electrodes with low-loss polymer waveguides for concurrent electrical recording and optical neuromodulation. Here we introduce two fabrication approaches: (1) an iterative thermal drawing with a soft, low melting temperature (T) metal indium, and (2) a metal convergence drawing with traditionally non-drawable high T metal tungsten. Read More

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October 2021

Self-Oxygenation of Tissues Orchestrates Full-Thickness Vascularization of Living Implants.

Adv Funct Mater 2021 Oct 6;31(42). Epub 2021 Jul 6.

Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge, MA 02139, USA.

Bioengineering of tissues and organs has the potential to generate functional replacement organs. However, achieving the full-thickness vascularization that is required for long-term survival of living implants has remained a grand challenge, especially for clinically sized implants. During the pre-vascular phase, implanted engineered tissues are forced to metabolically rely on the diffusion of nutrients from adjacent host-tissue, which for larger living implants results in anoxia, cell death, and ultimately implant failure. Read More

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October 2021

Polymer Chemistry for Haptics, Soft Robotics, and Human-Machine Interfaces.

Adv Funct Mater 2021 Sep 18;31(39). Epub 2021 Mar 18.

Department of NanoEngineering, University of California, San Diego 9500 Gilman Drive, Mail Code 0448, La Jolla, CA 92093-0448.

Progress in the field of soft devices-i.e., haptics, robotics, and human-machine interfaces (HRHMIs)-has its basis in the science of polymeric materials and chemical synthesis. Read More

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September 2021

Addressing Particle Compositional Heterogeneities in Super-Resolution-Enhanced Live-Cell Ratiometric pH Sensing with Ultrasmall Fluorescent Core-Shell Aluminosilicate Nanoparticles.

Adv Funct Mater 2021 Nov 7;31(45). Epub 2021 Aug 7.

Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, United States.

The interrogation of metabolic parameters like pH in live-cell experiments using optical super-resolution microscopy (SRM) remains challenging. This is due to a paucity of appropriate metabolic probes enabling live-cell SRM-based sensing. Here we introduce ultrasmall fluorescent core-shell aluminosilicate nanoparticle sensors (FAM-ATTO647N aC' dots) that covalently encapsulate a reference dye (ATTO647N) in the core and a pH-sensing moiety (FAM) in the shell. Read More

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November 2021

Camouflaged Hybrid Cancer Cell-Platelet Fusion Membrane Nanovesicles Deliver Therapeutic MicroRNAs to Presensitize Triple-Negative Breast Cancer to Doxorubicin.

Adv Funct Mater 2021 Oct 17;31(41). Epub 2021 Jul 17.

Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, California.

Camouflaged cell-membrane-based nanoparticles have been gaining increasing attention owing to their improved biocompatibility and immunomodulatory properties. Using nanoparticles prepared from the membranes of specific cell types, or fusions derived from different cells membranes, can improve their functional performance in several aspects. Here, we used cell membranes extracted from breast cancer cells and platelets to fabricate a hybrid-membrane vesicle fusion (cancer cell-platelet-fusion-membrane vesicle, CPMV) in which we loaded therapeutic microRNAs (miRNAs) for the treatment of triple-negative breast cancer (TNBC). Read More

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October 2021

Graphene-Based Technologies for Tackling COVID-19 and Future Pandemics.

Adv Funct Mater 2021 Sep 16:2107407. Epub 2021 Sep 16.

Centre for Print Research The University of West of England Bristol BS16 1QY UK.

The COVID-19 pandemic highlighted the need for rapid tools and technologies to combat highly infectious viruses. The excellent electrical, mechanical and other functional properties of graphene and graphene-like 2D materials (2DM) can be utilized to develop novel and innovative devices to tackle COVID-19 and future pandemics. Here, the authors outline how graphene and other 2DM-based technologies can be used for the detection, protection, and continuous monitoring of infectious diseases including COVID-19. Read More

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September 2021

Recellularization and Integration of Dense Extracellular Matrix by Percolation of Tissue Microparticles.

Adv Funct Mater 2021 Aug 23;31(35). Epub 2021 Jun 23.

Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO.

Cells embedded in the extracellular matrix of tissues play a critical role in maintaining homeostasis while promoting integration and regeneration following damage or disease. Emerging engineered biomaterials utilize decellularized extracellular matrix as a tissue-specific support structure; however, many dense, structured biomaterials unfortunately demonstrate limited formability, fail to promote cell migration, and result in limited tissue repair. Here, we developed a reinforced composite material of densely packed acellular extracellular matrix microparticles in a hydrogel, termed , that can be molded and crosslinked to mimic native tissue architecture. Read More

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Drug Delivery across Barriers to the Middle and Inner Ear.

Adv Funct Mater 2021 Oct 4;31(44). Epub 2020 Dec 4.

Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat these conditions. Here, recent advances in drug delivery systems that access the ear through the tympanic membrane (TM) are reviewed. Such methods are either non-invasive (placed on the surface of the TM), or invasive (placed in the middle ear, ideally on the round window [RW]). Read More

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October 2021

High-Throughput Magnetic Actuation Platform for Evaluating the Effect of Mechanical Force on 3D Tumor Microenvironment.

Adv Funct Mater 2021 Jan 23;31(1). Epub 2020 Sep 23.

Weldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Devices, Purdue University, West Lafayette, IN 47907, USA.

Accurately replicating and analyzing cellular responses to mechanical cues is vital for exploring metastatic disease progression. However, many of the existing platforms for applying mechanical stimulation seed cells on synthetic substrates. To better recapitulate physiological conditions, a novel actuating platform is developed with the ability to apply tensile strain on cells at various amplitudes and frequencies in a high-throughput multi-well culture plate using a physiologically-relevant substrate. Read More

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January 2021

Foliar Delivery of siRNA Particles for Treating Viral Infections in Agricultural Grapevines.

Adv Funct Mater 2021 Oct 10;31(44). Epub 2021 Jul 10.

Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.

Grapevine leafroll disease (GLD) is a globally spreading viral infection that causes major economic losses by reducing crop yield, plant longevity and berry quality, with no effective treatment. Grapevine leafroll associated virus-3 (GLRaV-3) is the most severe and prevalent GLD strain. Here, we evaluated the ability of RNA interference (RNAi), a non-GMO gene-silencing pathway, to treat GLRaV-3 in infected Cabernet Sauvignon grapevines. Read More

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October 2021

Efficient Drug Delivery into Skin Using a Biphasic Dissolvable Microneedle Patch with Water-Insoluble Backing.

Adv Funct Mater 2021 Oct 21;31(44). Epub 2021 Jun 21.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Dissolvable microneedle patches (MNPs) enable simplified delivery of therapeutics via the skin. However, most dissolvable MNPs do not deliver their full drug loading to the skin because only some of the drug is localized in the microneedles (MNs), and the rest remains adhered to the patch backing after removal from the skin. In this work, biphasic dissolvable MNPs are developed by mounting water-soluble MNs on a water-insoluble backing layer. Read More

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October 2021

Coating of a Novel Antimicrobial Nanoparticle with a Macrophage Membrane for the Selective Entry into Infected Macrophages and Killing of Intracellular Staphylococci.

Adv Funct Mater 2020 Nov 16;30(48). Epub 2020 Sep 16.

Department of Biomedical Engineering, University of Groningen and University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

Internalization of by macrophages can inactivate bacterial killing mechanisms, allowing intracellular residence and dissemination of infection. Concurrently, these staphylococci can evade antibiotics that are frequently unable to pass mammalian cell membranes. A binary, amphiphilic conjugate composed of triclosan and ciprofloxacin is synthesized that self-assemble through micelle formation into antimicrobial nanoparticles (ANPs). Read More

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November 2020

Ultra-selective carbon nanotubes for photoacoustic imaging of inflamed atherosclerotic plaques.

Adv Funct Mater 2021 Sep 17;31(37). Epub 2021 Jun 17.

Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.

Disruption of vulnerable atherosclerotic plaques often leads to myocardial infarction and stroke, the leading causes of morbidity and mortality in the United States. A diagnostic method that detects high-risk atherosclerotic plaques at early stages could prevent these sequelae. The abundance of immune cells in the arterial wall, especially inflammatory Ly-6C monocytes and foamy macrophages, is indicative of plaque‎ inflammation, and may be associated with plaque vulnerability. Read More

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September 2021

Powering Implantable and Ingestible Electronics.

Adv Funct Mater 2021 Oct 4;31(44). Epub 2021 Feb 4.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Implantable and ingestible biomedical electronic devices can be useful tools for detecting physiological and pathophysiological signals, and providing treatments that cannot be done externally. However, one major challenge in the development of these devices is the limited lifetime of their power sources. The state-of-the-art of powering technologies for implantable and ingestible electronics is reviewed here. Read More

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October 2021

Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy.

Adv Funct Mater 2021 Apr 22;31(17). Epub 2021 Feb 22.

Department of Biomedical Engineering and Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Departments of Materials Science and Engineering, Neurosurgery, Oncology, Ophthalmology, and Chemical and Biomolecular Engineering, Sidney Kimmel Comprehensive Cancer Center, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Clinical translation of polymer-based nanocarriers for systemic delivery of RNA has been limited due to poor colloidal stability in the blood stream and intracellular delivery of the RNA to the cytosol. To address these limitations, this study reports a new strategy incorporating photocrosslinking of bioreducible nanoparticles for improved stability extracellularly and rapid release of RNA intracellularly. In this design, the polymeric nanocarriers contain ester bonds for hydrolytic degradation and disulfide bonds for environmentally triggered small interfering RNA (siRNA) release in the cytosol. Read More

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Bioprinting Neural Systems to Model Central Nervous System Diseases.

Adv Funct Mater 2020 Oct 22;30(44):1910250. Epub 2020 Apr 22.

Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences (UIPS) Utrecht University Universiteitsweg 99 Utrecht 3584 CG The Netherlands.

To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell culture systems cannot recapitulate the in vivo complexity of neural systems. The search for valuable models of neurodegenerative diseases has recently been revived by the addition of 3D culture that allows to re-create the in vivo microenvironment including the interactions among different neural cell types and the surrounding extracellular matrix (ECM) components. Read More

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October 2020

Maximizing Chiral Perturbation on Thermally Activated Delayed Fluorescence Emitters and Elaboration of the First Top-Emission Circularly Polarized OLED.

Adv Funct Mater 2020 Oct 23;30(43). Epub 2020 Aug 23.

Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS) SCBM, Gif-sur-Yvette F-91191, France.

Molecular designs merging circularly polarized luminescence (CPL) and thermally activated delayed fluorescence (CP-TADF) using the concept of chiral perturbation appeared recently as a cornerstone for the development of efficient CP-organic light emitting diodes (CP-OLED). Such devices could strongly increase the energy efficiency and performances of conventional OLED displays, in which 50% of the emitted light is often lost due to the use of antiglare filters. In this context, herein, ten couples of enantiomers derived from novel chiral emitter designs are reported, exhibiting CPL, TADF, and aggregation induced enhancement emission properties (AIEE). Read More

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October 2020

Heparin Microislands in Microporous Annealed Particle Scaffolds for Accelerated Diabetic Wound Healing.

Adv Funct Mater 2021 Aug 18;31(35). Epub 2021 Jun 18.

Department of Biomedical Engineering, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908.

Mimicking growth factor-ECM interactions for promoting cell migration is a powerful technique to improve tissue integration with biomaterial scaffolds for the regeneration of damaged tissues. This has been attempted by scaffold-mediated controlled delivery of exogenous growth factors; however, the predetermined nature of this delivery can limit the scaffold's ability to meet each wound's unique spatiotemporal regenerative needs and presents translational hurdles. To address this limitation, we present a new approach to growth factor presentation by incorporating heparin microislands, which are spatially isolated heparin-containing microparticles that can reorganize and protect endogenous local growth factors via heterogeneous sequestration at the microscale and result in functional improvements in wound healing. Read More

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Poly(catecholamine) coated CsPbBr perovskite microlasers: lasing in water and biofunctionalization.

Adv Funct Mater 2021 Jul 25;31(27). Epub 2021 Apr 25.

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Cambridge, Massachusetts, 02139, USA.

Lead halide perovskite (LHP) is a promising material for various optoelectronic applications. Surface coating on particles is a common strategy to improve their functionality and environmental stability, but LHP is not amenable to most coating chemistries because of its intrinsic weakness against polar solvents. Here, we describe a novel method of synthesizing LHP microlasers in a super-saturated polar solvent using sonochemistry and applying various functional coatings on individual microlasers . Read More

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Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells.

Adv Funct Mater 2021 May 12;31(20):2010747. Epub 2021 Mar 12.

Department of Biomedicine University Hospital Basel University of Basel Basel 4031 Switzerland.

The thymus provides the physiological microenvironment critical for the development of T lymphocytes, the cells that orchestrate the adaptive immune system to generate an antigen-specific response. A diverse population of stroma cells provides surface-bound and soluble molecules that orchestrate the intrathymic maturation and selection of developing T cells. Forming an intricate 3D architecture, thymic epithelial cells (TEC) represent the most abundant and important constituent of the thymic stroma. Read More

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