765,552 results match your criteria Advanced Engineering Informatics[Journal]

The microenvironment of Silk/Gelatin nanofibrous scaffold improves proliferation and differentiation of wharton's jelly-derived mesenchymal cells into islet-like cells.

Gene 2022 May 18:146586. Epub 2022 May 18.

Department of Medical Biotechnology, Molecular and Cell Biology Research Center, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

The use of umbilical cord-derived mesenchymal stem cells along with three-dimensional (3D) scaffolds in pancreatic tissue engineering can be considered as a treatment for diabetes. This study aimed to investigate the differentiation of Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) into pancreatic islet-insulin producing cells (IPCs) on silk/gelatin nanofibers as a 3D scaffold. Mesenchymal markers were evaluated at the mesenchymal stem cells (MSCs) level by flowcytometry. Read More

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Role of the TATA-box binding protein (TBP) and associated family members in transcription regulation.

Gene 2022 May 18:146581. Epub 2022 May 18.

Department of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, C.P. 07360 Mexico City, Mexico. Electronic address:

The assembly of transcription complexes on eukaryotic promoters involves a series of steps, including chromatin remodeling, recruitment of TATA-binding protein (TBP)-containing complexes, the RNA polymerase II holoenzyme, and additional basal transcription factors. This review describes the transcriptional regulation by TBP and its corresponding homologs that constitute the TBP family and their interactions with promoter DNA. The C-terminal core domain of TBP is highly conserved and contains two structural repeats that fold into a saddle-like structure, essential for the interaction with the TATA-box on DNA. Read More

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Artificial intelligence in virtual screening: models versus experiments.

Drug Discov Today 2022 May 18. Epub 2022 May 18.

Advanced Computation and Data Sciences Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, 785006, India.

A typical drug discovery project involves identifying active compounds with significant binding potential for selected disease-specific targets. Experimental high-throughput screening (HTS) is a traditional approach to drug discovery, but is expensive and time-consuming when dealing with huge chemical libraries with billions of compounds. The search space can be narrowed down with the use of reliable computational screening approaches. Read More

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Exposure levels of PCDD/Fs and PCBs in human blood and the transplacental transfer characteristics in cord blood of newborns near the industrialized area.

Chemosphere 2022 May 18:134995. Epub 2022 May 18.

School of Environmental & Safety Engineering, Changzhou University, Changzhou, 213164, China.

Mono-to octa-chlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in pooled blood from the general population living near a typical industrialized area were investigated. Less chlorinated PCDD/Fs (mean: 2602 pg L) were 7.5 times those of highly chlorinated ones (mean: 349 pg L). Read More

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Molecular Mechanisms Underlying the Development of Neuroendocrine Prostate Cancer.

Semin Cancer Biol 2022 May 18. Epub 2022 May 18.

Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, CA, USA. Electronic address:

Prostate cancer is the most common non-cutaneous cancer and the second leading cause of cancer-associated deaths among men in the United States. Androgen deprivation therapy (ADT) is the standard of care for advanced prostate cancer. While patients with advanced prostate cancer initially respond to ADT, the disease frequently progresses to a lethal metastatic form, defined as castration-resistant prostate cancer (CRPC). Read More

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Emerging cases of acute hepatitis of unknown origin in children amid the ongoing COVID-19 pandemic: Needs attention - Correspondence.

Int J Surg 2022 May 18:106682. Epub 2022 May 18.

Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Izatnagar, Uttar Pradesh, 243122, India. Electronic address:

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Mechanistic insight into differential interactions of iron oxide nanoparticles with native, glycated albumin and their effect on erythrocytes parameters.

Int J Biol Macromol 2022 May 18. Epub 2022 May 18.

Symbiosis School of Biological Sciences (SSBS), Symbiosis International (Deemed University) (SIU), Lavale, Pune 412115, Maharashtra, India. Electronic address:

Nanoparticles and protein bioconjugates have been studied for multiple biomedical applications. We sought to investigate the interaction and structural modifications of bovine serum albumin (BSA) with iron oxide nanoparticles (IONPs). The IONPs were green synthesized using E. Read More

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Ontogeny-dependent effects of elevated CO and watering frequency on interaction between Aristolochia contorta and its herbivores.

Sci Total Environ 2022 May 18:156065. Epub 2022 May 18.

Department of Biology Education, Seoul National University, Seoul 08826, Republic of Korea; Center for Education Research, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Effects of environmental change on plants can differ due to sequential changes in their life-history strategies (i.e., ontogenetic variations). Read More

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Understanding Interactions between Biomolecules and Two-Dimensional Nanomaterials Using in silico Microscopes.

Adv Drug Deliv Rev 2022 May 18:114336. Epub 2022 May 18.

IBM Thomas J. Watson Research, Yorktown Heights, New York, 10598, USA. Electronic address:

Two-dimensional (2D) nanomaterials such as graphene are increasingly used in research and industry for various biomedical applications. Extensive experimental and theoretical studies have revealed that 2D nanomaterials are promising drug delivery vehicles, yet certain materials exhibit toxicity under biological conditions. So far, it is known that 2D nanomaterials possess strong adsorption propensities for biomolecules. Read More

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Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice.

Exp Neurol 2022 May 18:114118. Epub 2022 May 18.

Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.

Clinical evidence indicates that patients with temporal lobe epilepsy (TLE) often show differential outcomes of comorbid conditions in relation to the lateralization of the seizure focus. A particularly strong relationship exists between the side of seizure focus and the propensity for distinct reproductive endocrine comorbidities in women with TLE. Therefore, here we evaluated whether targeting of left or right dorsal hippocampus for intrahippocampal kainic acid (IHKA) injection, a model of TLE, produces different outcomes in hippocampal granule cell dispersion, body weight gain, and multiple measures of reproductive endocrine dysfunction in female mice. Read More

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Matrine inhibits advanced glycation end products-induced macrophage M1 polarization by reducing DNMT3a/b-mediated DNA methylation of GPX1 promoter.

Eur J Pharmacol 2022 May 18:175039. Epub 2022 May 18.

Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China; Cardiovascular Research Center, Shaanxi Provincial People's Hospital, Xi'an, 710068, China; Affiliated Shaanxi Provincial People's Hospital, Northwestern Polytechnical University, Xi'an, 710072, China. Electronic address:

Advanced glycation end products (AGEs) are characterized diabetic metabolites inducing macrophage M1 polarization which is crucial in diabetes-exacerbated atherosclerosis. Matrine was proved anti-atherosclerotic. The current study was aimed to investigate the inhibitory effects of matrine on AGEs- induced macrophage M1 polarization and underlying molecular mechanisms. Read More

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TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.

Cell 2022 May 13. Epub 2022 May 13.

Institute of Biochemistry, University of Cologne, Cologne, Germany; Max Planck Institute for Plant Breeding Research, Cologne, Germany; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, China. Electronic address:

2',3'-cAMP is a positional isomer of the well-established second messenger 3',5'-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide monophosphate (cNMP). Toll/interleukin-1 receptor (TIR) domains of nucleotide-binding leucine-rich repeat (NLR) immune receptors have the NADase function necessary but insufficient to activate plant immune responses. Here, we show that plant TIR proteins, besides being NADases, act as 2',3'-cAMP/cGMP synthetases by hydrolyzing RNA/DNA. Read More

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Advanced oxidation processes: Performance, advantages, and scale-up of emerging technologies.

J Environ Manage 2022 May 18;316:115295. Epub 2022 May 18.

Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, Baltimore, MD, 21250, USA. Electronic address:

Advanced oxidation processes (AOPs) are promising technologies for partial or complete mineralization of contaminants of emerging concern by highly reactive hydroxyl, hydroperoxyl, superoxide, and sulphate radicals. Detailed investigations and reviews have been reported for conventional AOP systems that have been installed in full-scale wastewater treatment plants. However, recent efforts have focused on the peroxymonosulphate, persulphate, catalytic ozonation, ultrasonication and hydrodynamic cavitation, gamma radiation, electrochemical oxidation, modified Fenton, and plasma-assisted AOPs. Read More

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Households' perceptions and socio-economic determinants of climate change awareness: Evidence from Selangor Coast Malaysia.

J Environ Manage 2022 May 18;316:115261. Epub 2022 May 18.

Department of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia; USQ's Advanced Data Analytics Research Group, School of Mathematics Physics and Computing, University of Southern Queensland, QLD, 4350, Australia; New era and Development in Civil Engineering Research Group, Scientific Research Center, Al-Ayen University, Thi-Qar, 64001, Iraq. Electronic address:

Households living in the close vicinity of shoreline are constantly threatened by various climate change impacts. Community awareness towards climate change is a subject of considerable study as adequate knowledge is a preliminary step for adaptation decision making. An important question is how coastal communities perceive climatic variation, sea level rise and coastal hazard impacts and the socio-economic factors that affect their level of awareness. Read More

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ADRIS: The new open-source accessible driving simulator for training and evaluation of driving abilities.

Comput Methods Programs Biomed 2022 May 10;221:106857. Epub 2022 May 10.

Department of Informatics, Bioengineering, Robotics, and Systems Engineering, University of Genova, Via Pastore 3, Genova 16132, Italy; Simulation and Advanced Education Center, University of Genova, Via all'Opera Pia 13, Genova 16145, Italy; Spinal Cord Italian Laboratory, Spinal Cord Unit, Santa Corona Hospital, ASL2 Savonese, Pietra Ligure, Italy. Electronic address:

Background And Objective: Independent living and transportation are crucial aspects for people living with a disability. After an injury, it is important to assess driving ability, in terms of physical and psychological conditions, and to test the effects of prescribed drugs. Within this framework, driving simulators are suitable tools for training driving skills; however, available tools are expensive or lack appropriate sets of behavioral measures to fully characterize the drivers' ability. Read More

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Advances in PSMA theranostics.

Transl Oncol 2022 May 18;22:101450. Epub 2022 May 18.

Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, Belfer Research Building, 413 East 69th Street, Room BB-1604, New York, NY 10021, USA; Weill Cornell Medicine, Citigroup Biomedical Imaging Center, New York, NY 10021, USA. Electronic address:

The validation of prostate specific membrane antigen (PSMA) as a molecular target in metastatic castration-resistant prostate cancer has stimulated the development of multiple classes of theranostic ligands that specifically target PSMA. Theranostic ligands are used to image disease or selectively deliver cytotoxic radioactivity to cells expressing PSMA according to the radioisotope conjugated to the ligand. PSMA theranostics is a rapidly advancing field that is now integrating into clinical management of prostate cancer patients. Read More

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Towards a novel approach guiding the decision-making process for anticancer treatment in patients with advanced cancer: framework for systemic anticancer treatment with palliative intent.

ESMO Open 2022 May 18;7(3):100496. Epub 2022 May 18.

Cancer Fatigue Clinic at Onkologie Schaffhausen, Schaffhausen and Center Integrative Medicine, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; Center Integrative Medicine, Department Internal Medicine, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Background: Weighing risks and benefits is currently the primary criterion for decisions regarding systemic anticancer treatment (SACT) in far advanced cancer patients, also in the modern immunotherapy- and molecular-targeted driven oncology. Decision aids rarely include substantially key concepts of early integrated palliative care (PC) and communication science. We compiled decisional factors (DFs) important for guiding the use of SACT with palliative intent (SACT-PI) and explored these DFs regarding their applicability in routine clinical care. Read More

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Amivantamab compared with real-world therapies in patients with advanced non-small cell lung cancer harboring EGFR exon 20 insertion mutations who progressed after platinum-based chemotherapy.

Lung Cancer 2022 Mar 8;168:74-82. Epub 2022 Mar 8.

Institut Curie, Institut du Thorax Curie-Montsouris, Paris, France. Electronic address:

Background: In the single-arm CHRYSALIS study, amivantamab showed durable responses and manageable safety in patients with advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) exon 20 insertion mutations (ex20ins) who progressed on prior platinum-based chemotherapy. External controls can provide context for interpreting amivantamab efficacy.

Methods: External controls were selected from three US-based databases (ConcertAI, COTA, and Flatiron). Read More

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Induced circular dichroism as a tool to monitor the displacement of ligands between albumins.

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 14;278:121374. Epub 2022 May 14.

Department of Chemistry, Faculty of Sciences, UNESP - São Paulo State University, 17033-360 Bauru, São Paulo, Brazil. Electronic address:

The induction of chirality in a ligand can be a powerful analytical tool for studying protein-ligand interactions. Here, we advanced by applying the technique to monitor the inversion of the induced circular dichroism (ICD) spectrum when ligands move between human and bovine serum albumin proteins (HSA and BSA). ICD experiments were performed using dimers of methyl vanillate (DVT) and vanillin (DVN). Read More

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Activin-A, Growth Differentiation Factor-11 and Transforming Growth Factor-β as predictive biomarkers for platinum chemotherapy in advanced non-small cell lung cancer.

Cancer Treat Res Commun 2022 May 13;32:100576. Epub 2022 May 13.

The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, Australia; The University of New South Wales, Sydney, Australia; St Vincent's Hospital, 390 Victoria Street Darlinghurst, Sydney, Australia. Electronic address:

Background: Despite advances in immunotherapy and targeted therapy, platinum-based chemotherapy remains crucial for many patients with advanced non-small cell lung cancer (NSCLC). Resistance to platinum chemotherapy is common, and predictive biomarkers are needed to tailor treatment to patients likely to respond. In vitro evidence implicates the transforming growth factor-β (TGF-β) superfamily ligands activin-A and growth differentiation factor 11 (GDF-11) in innate platinum resistance. Read More

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Comparative safety of immune checkpoint inhibitors and chemotherapy in advanced non-small cell lung cancer: A systematic review and network meta-analysis.

Int Immunopharmacol 2022 May 18;108:108848. Epub 2022 May 18.

School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan; Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan; Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung, Taiwan. Electronic address:

Backgrounds: Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy (CT) are the standard of care for first-line therapy in metastatic non-small cell lung cancer (NSCLC) patients without actionable mutations. The safety ranking of different ICI and CT combination regimens has not been investigated. This study was aimed to provide a toxicity profile and safety ranking of different ICI and CT combination regimens. Read More

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Background-free room temperature phosphorescence and digital image colorimetry detection of melamine by carbon nitride quantum dots in cellulose matrix with smartphone-based portable device.

Food Chem 2022 May 2;390:133135. Epub 2022 May 2.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.

Carbon nitride quantum dots (CNQDs) were embedded in the sodium carboxymethyl cellulose (CMC) matrix to form CNQDs-CMC film to explore the room temperature phosphorescence (RTP) of CNQDs, which suppress the non-radiative relaxation process due to the internal hydrogen bonding interactions between CMC and CNQDs. Then, a simple, inexpensive, background-free miniature device integrating with CNQDs-CMC film and smartphone was fabricated for rapid and quantitative detection of melamine (MEL). In the present of MEL, the yellow RTP color of the CNQDs-CMC film was quenched and photographed by the smartphone. Read More

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Immune checkpoint inhibition in patients with inactive pre-existing neuromuscular autoimmune diseases.

J Neurol Sci 2022 May 2;438:120275. Epub 2022 May 2.

Division of Neuromuscular Medicine, Department of Neurology, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USA. Electronic address:

Objectives: To evaluate the safety of immune checkpoint inhibitor use in patients with pre-existing neurological autoimmune diseases.

Methods: In this retrospective case-series, we examined exacerbations of underlying disease and the occurrence of immune-related adverse events in 5 patients who had been diagnosed with a neurological autoimmune disease prior to receiving immune checkpoint inhibitor therapy for advanced malignancy.

Results: Two patients had a prior diagnosis of myasthenia gravis, two had Guillain-Barré syndrome, and one had chronic idiopathic demyelinating polyneuropathy. Read More

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Chemistry and engineering of brush type polymers: Perspective towards tissue engineering.

Adv Colloid Interface Sci 2022 May 11;305:102694. Epub 2022 May 11.

Biorefining and Advanced Materials Research Center, SRUC (Scotland's Rural College), Edinburgh EH9 3JG, UK; School of Engineering, University of Petroleum & Energy Studies (UPES), Dehradun 248007, Uttarakhand, India. Electronic address:

In tissue engineering, it is imperative to control the behaviour of cells/stem cells, such as adhesion, proliferation, propagation, motility, and differentiation for tissue regeneration. Surfaces that allow cells to behave in this way are critical as support materials in tissue engineering. Among these surfaces, brush-type polymers have an important potential for tissue engineering and biomedical applications. Read More

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Lithiophilic hollow Co[Co(CN)] embedded carbon nanotube film for dendrite-free lithium metal anodes.

J Colloid Interface Sci 2022 May 13;623:532-540. Epub 2022 May 13.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, PR China.

Lithium metal is considered to be an ideal anode material due to its ultra-high theoretical capacity and extremely low electric potential. Unfortunately, the infinite volume expansion and unregulated formation of lithium dendrites in the plating/stripping process restrict its practical utilization. Herein, we designed a hollow Co[Co(CN)] (CoCoPBA) embedded high-conductivity carbon film as a three-dimensional (3D) lithiophilic current collector ([email protected]). Read More

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Nitrite reduction over Ag nanoarray electrocatalyst for ammonia synthesis.

J Colloid Interface Sci 2022 May 6;623:513-519. Epub 2022 May 6.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China. Electronic address:

Electrochemical reduction of nitrite to ammonia can simultaneously achieve ammonia synthesis and N-contaminant removal under mild conditions, which has attracted widespread attention but still lacks efficient catalysts. In this work, Ag nanoarray using NiO nanosheets array on carbon cloth as support is reported as an efficient electrocatalyst to selectively reduce nitrite to ammonia. In 0. Read More

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Dual-anions engineering of bimetallic oxides as highly active electrocatalyst for boosted overall water splitting.

J Colloid Interface Sci 2022 May 10;623:467-475. Epub 2022 May 10.

Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Bimetallic oxides have unique advantages in driving both oxygen and hydrogen evolution reactions (OER/HER). Surface engineering of bimetallic oxides is a promising way to boost the catalytic activity by the regulation of electronic structure and surface property. Herein, a dual P, S-anions modification strategy is developed to optimize the catalytic performance of CoMoO nanowire arrays. Read More

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Fate of face masks after being discarded into seawater: Aging and microbial colonization.

J Hazard Mater 2022 May 5;436:129084. Epub 2022 May 5.

Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen 518060 Guangdong, China. Electronic address:

Billions of discarded masks have entered the oceans since the outbreak of the COVID-19 pandemic. Current reports mostly discuss the potential of masks as plastic pollution, but there has been no study on the fate of this emerging plastic waste in the marine environment. Therefore, we exposed masks in natural seawater and evaluated their aging and effects on the microbial community using a combination of physicochemical and biological techniques. Read More

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The LRRC8C-STING-p53 axis in T cells: A Ca affair.

Cell Calcium 2022 May 13;105:102596. Epub 2022 May 13.

Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. Electronic address:

Up to now, no role has been associated with VRAC channels in T cells. In a recent paper published in Nature Immunology, LRRC8C has been described as an essential component of VRAC in T cells. These data raise the intriguing possibility that the LRRC8C-STING-p53 signaling axis may represent a new inhibitory pathway in T cells that controls their function and adaptive immunity. Read More

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