605,327 results match your criteria Advanced Engineering Informatics[Journal]


Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States.

J Intern Med 2020 Jun 4. Epub 2020 Jun 4.

Internal Medicine Department, Beaumont Health, Royal Oak, MI, USA.

Introduction: Higher comorbidity and older age have been reported as correlates of poor outcomes in COVID-19 patients worldwide, however US data is scarce. We evaluated mortality predictors of COVID-19 in a large cohort of hospitalized patients in the US.

Design: Retrospective, multicenter cohort of inpatients diagnosed with COVID-19 by RT-PCR from March 1-April 1,2020 was performed, and outcome data evaluated from March 1-April 17, 2020. Read More

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http://dx.doi.org/10.1111/joim.13119DOI Listing

Role of inflammasomes in innate host defense against Entamoeba histolytica.

J Leukoc Biol 2020 Jun 4. Epub 2020 Jun 4.

Department of Microbiology, Immunology and Infectious Diseases, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada.

Intestinal amebiasis is the disease caused by the extracellular protozoan parasite Entamoeba histolytica (Eh) that induces a dynamic and heterogeneous interaction profile with the host immune system during disease pathogenesis. In 90% of asymptomatic infection, Eh resides with indigenous microbiota in the outer mucus layer of the colon without prompting an immune response. However, for reasons that remain unclear, in a minority of the Eh-infected individuals, this fine tolerated relationship is switched to a pathogenic phenotype and advanced to an increasingly complex host-parasite interaction. Read More

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http://dx.doi.org/10.1002/JLB.3MR0420-465RDOI Listing

Quantitative MRI as an imaging marker of concussion: evidence from studying repeated events.

Eur J Neurol 2020 Jun 4. Epub 2020 Jun 4.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.

We present a 23-year-old male professional Australian Football player who experienced a total of seven sports-related concussions between May-2015-March-2019, not associated with loss of consciousness (see supplementary materials for clinical details). Advanced brain imaging was performed after the latter four of these, revealing that his brain underwent a pattern of focal, but transient, increases in T2 relaxometry following concussive events. Read More

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http://dx.doi.org/10.1111/ene.14377DOI Listing

Partnership between Nurse Navigators and adult persons living with complex chronic disease - an exploratory study.

J Clin Nurs 2020 Jun 4. Epub 2020 Jun 4.

School of Nursing & Midwifery &, Menzies Health Institute, Griffith University.

Aims: The aim of this study was to explore Nurse Navigators and consumers' experience of partnership.

Background: The Nurse Navigator has recently emerged as an advanced practice role in the care of persons with complex and chronic disease states. Self-care is an important principle in chronic disease models of care, requiring health care practitioners to partner with clients in their care. Read More

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http://dx.doi.org/10.1111/jocn.15364DOI Listing

[Robot-Assisted Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery: Implementation Using a Stepwise Approach and Analyses of the First 100 Surgical Procedures].

Zentralbl Chir 2020 Jun 4;145(3):234-245. Epub 2020 Jun 4.

Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Deutschland.

Introduction: Robot-assisted surgery is a promising technique for overcoming the limitations of laparoscopic surgery, especially for complex and advanced surgical procedures. We now describe the implementation of our robotic upper GI and HPB surgery program in our centre of excellence for minimally invasive surgery and the results of our first 100 surgical procedures.

Method: Robot-assisted surgery was performed using the Da Vinci Xi Surgical System. Read More

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http://dx.doi.org/10.1055/a-1135-9277DOI Listing

[Teaching and Training in Robot-assisted Surgery].

Zentralbl Chir 2020 Jun 4;145(3):271-277. Epub 2020 Jun 4.

Chirurgische Klinik, Charité Universitätsmedizin Berlin, Deutschland.

The development and proliferation of robot-assisted surgery has greatly extended the field of minimally invasive surgery. Thus, this necessitates the development of adequate training programs to prepare surgeons for the operating room of the future. Transferring established and proven methods of training and assessment in aviation could help robotic training programs become more effective, efficient and safer. Read More

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http://dx.doi.org/10.1055/a-1156-4357DOI Listing

Coagulopathy in COVID-19 and Its Implication for Safe and Efficacious Thromboprophylaxis.

Hamostaseologie 2020 Jun 4. Epub 2020 Jun 4.

Institut für Experimentelle Hämatologie und Transfusionsmedizin, Universitätsklinik Bonn, Bonn, Germany.

The novel coronavirus, SARS-CoV-2, is causing a global pandemic of life-threatening multiorgan disease, called COVID-19. Accumulating evidence indicates that patients with COVID-19 are at significant risk of thromboembolic complications, mainly affecting the venous, but also the arterial vascular system. While the risk of venous thromboembolism (VTE) appears to be higher in patients requiring intensive care unit support compared to those admitted to general wards, recent autopsy findings and data on the timing of VTE diagnosis relative to hospitalization clearly suggest that thromboembolic events also contribute to morbidity and mortality in the ambulatory setting. Read More

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http://dx.doi.org/10.1055/a-1178-3551DOI Listing

Low-temperature synthesis and electrocatalytic application of large-area PtTe2 thin films.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

AMBER and School of Chemistry, University of Dublin Trinity College, Dublin, 2, IRELAND.

The synthesis of transition metal dichalcogenides (TMDs) has been a primary focus for 2D nanomaterial research over the last 10 years, however, only a small fraction of this research has been concentrated on transition metal ditellurides. In particular, nanoscale platinum ditelluride (PtTe2) has rarely been investigated, despite its potential applications in catalysis, photonics and spintronics. Of the reports published, the majority examine mechanically-exfoliated flakes from chemical vapor transport (CVT) grown crystals. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9973DOI Listing

Dual-gate control of the surface carriers of the highly-bulk-resistive topological insulator Sn0.02Bi1.08Sb0.9Te2S.

J Phys Condens Matter 2020 Jun 4. Epub 2020 Jun 4.

Materials and Structures Laboratory, Tokyo Institute of Technology, Yokohama, Kanagawa, JAPAN.

Exotic surface states of topological insulators have long attracted the attention of researchers. Recently, surface-dominant electrical transport in topological insulators has been observed; however, surface conduction in topological insulators is still not fully understood. To address this knowledge gap, we measured the transport properties of a thin flake of a highly bulk-resistive topological insulator, SnBiSbTeS (Sn-BSTS), whose carrier density was controlled with the field effect. Read More

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http://dx.doi.org/10.1088/1361-648X/ab997eDOI Listing

Noncoplanar ferrimagnetism and local crystalline-electric-field anisotropy in the quasicrystal approximant Au70Si17Tb13.

J Phys Condens Matter 2020 Jun 4. Epub 2020 Jun 4.

Dept. Materials Science & Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo, Tokyo, 125-8585, JAPAN.

Neutron scattering experiments have been performed to elucidate magnetic properties of the qua- sicrystal approximant Au70Si17Tb13, consisting of icosahedral spin clusters in a body-centered-cubic lattice. Bulk magnetic measurements performed on the single crystalline sample unambiguously confirm long-range ordering at TC = 11.6 ± 1 K. Read More

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http://dx.doi.org/10.1088/1361-648X/ab997dDOI Listing

Adaptation and Validation of the Health Belief Model Scale for Breast Self-Examination in Mexican Women.

Value Health Reg Issues 2020 May 31;23:30-36. Epub 2020 May 31.

Psychology School, Center for Research and Development in Health Sciences, Autonomous University of Nuevo Leon, Monterrey, Mexico.

Objectives: In Mexico, breast cancer is often not detected until it is already at an advanced stage. Many women know about breast self-examination (BSE), but few do it correctly. BSE can assist in the early detection of breast cancer, and a valid and reliable instrument to help determine the factors of the Health Belief Model that affect the practice of BSE in Mexican women would thus be advantageous. Read More

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http://dx.doi.org/10.1016/j.vhri.2019.11.006DOI Listing

Detecting Ferric Iron by Microalgal Residue-Derived Fluorescent Nanosensor with an Advanced Kinetic Model.

iScience 2020 May 18;23(6):101174. Epub 2020 May 18.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin 150090, P. R. China. Electronic address:

Biomass-derived carbon quantum dots (CQDs) are attractive to serve as fluorescent nanosensors owing to their superior environmental compatibility and biocompatibility. However, the detection range has been limited, only in partial agreement with the experimental data. Thus, an advanced kinetic model for quantifying the fluorescence quenching over a wide range is on demand. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101174DOI Listing

AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication.

iScience 2020 May 18;23(6):101183. Epub 2020 May 18.

Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo 187-8502, Japan. Electronic address:

Impairments in synapse development are thought to cause numerous psychiatric disorders. Autism susceptibility candidate 2 (AUTS2) gene has been associated with various psychiatric disorders, such as autism and intellectual disabilities. Although roles for AUTS2 in neuronal migration and neuritogenesis have been reported, its involvement in synapse regulation remains unclear. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101183DOI Listing

Columnar aerosol properties and radiative effects over Dushanbe, Tajikistan in Central Asia.

Environ Pollut 2020 May 25;265(Pt B):114872. Epub 2020 May 25.

State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China; Center for Excellence in Tibetan Plateau Earth Sciences, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:

This paper presents the results of the study on columnar aerosol optical and physical properties and radiative effects directly observed over Dushanbe, the capital city of Tajikistan, a NASA AERONET site (equipped with a CIMEL sunphotometer) in Central Asia. The average aerosol optical depth (AOD) and Ångström exponent (AE) during the observation period from July 2010 to April 2018 were found to be 0.28 ± 0. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114872DOI Listing

Ultrathin hetero-nanosheets assembled hollow Ni-Co-P/C for hybrid supercapacitors with enhanced rate capability and cyclic stability.

J Colloid Interface Sci 2020 May 25;577:368-378. Epub 2020 May 25.

State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, PR China.

Nanohybrid-type Ni-Co-phosphide/C (Ni-Co-P/C) hollow microflowers with ultrathin nanosheets (HUNs) are constructed through a modified ethylene glycol-mediated self-assembly process and further phosphating treatment. The peculiar structure can availably provide affluent mass transfer channels and active sites, meanwhile inhibit the aggregation of nanosheets. The synergistic effects of the produced Ni-Co-P/C are demonstrated systematically through regulating the initial Ni/Co ratio. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.05.065DOI Listing

Hepatic arterial infusion of oxaliplatin plus raltitrexed in patients with intermediate and advanced stage hepatocellular carcinoma: A phase II, single-arm, prospective study.

Eur J Cancer 2020 Jun 1;134:90-98. Epub 2020 Jun 1.

Department of Interventional Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, No. 420, Fuma Road, Fuzhou 350014, China. Electronic address:

Purpose: To investigate the efficacy and safety of hepatic arterial infusion (HAI) of oxaliplatin plus raltitrexed in patients with intermediate stage and advanced stage hepatocellular carcinoma (HCC).

Methods: In this phase II, single-arm clinical trial, we enrolled patients aged 18-70 years with intermediate stage and advanced stage HCC, which included patients with HCC at Barcelona Clinic Liver Cancer (BCLC) stage B who experienced transcatheter arterial chemoembolization failure/refractoriness, and those with BCLC stage C with portal vein invasion. We performed HAI with oxaliplatin and raltitrexed. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.03.032DOI Listing

Do food and stress biomarkers work for wastewater-based epidemiology? A critical evaluation.

Sci Total Environ 2020 May 25;736:139654. Epub 2020 May 25.

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Australia.

Dietary characteristics and oxidative stress are closely linked to the wellbeing of individuals. In recent years, various urinary biomarkers of food and oxidative stress have been proposed for use in wastewater-based epidemiology (WBE), in efforts to objectively monitor the food consumed and the oxidative stress experienced by individuals in a wastewater catchment. However, it is not clear whether such biomarkers are suitable for wastewater-based epidemiology. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139654DOI Listing

Anaerobic oxidation of methane and associated microbiome in anoxic water of Northwestern Siberian lakes.

Sci Total Environ 2020 May 25;736:139588. Epub 2020 May 25.

Laboratory of Functional Ecology and Environment, Université de Toulouse, CNRS, Toulouse, France. Electronic address:

Arctic lakes emit methane (CH) to the atmosphere. The magnitude of this flux could increase with permafrost thaw but might also be mitigated by microbial CH oxidation. Methane oxidation in oxic water has been extensively studied, while the contribution of anaerobic oxidation of methane (AOM) to CH mitigation is not fully understood. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139588DOI Listing

Bioavailability of polycyclic aromatic compounds (PACs) to the Sydney rock oyster (Saccostrea glomerata) from sediment matrices of an economically important Australian estuary.

Sci Total Environ 2020 May 21;736:139574. Epub 2020 May 21.

Global Innovative Centre for Advanced Nanomaterials (GICAN), University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address:

Improving risk assessment and remediation rests on better understanding of contaminant bioavailability. Despite their strong toxicological attributes, little is known about the partitioning behaviour and bioavailability of polar polycyclic aromatic hydrocarbons (PAHs) in aquatic environments. The present study provides an insight into the bioavailable fractions of polar PAHs and their parent analogues in the tissues of the Sydney rock oyster, Saccostrea glomerata, a model aquatic bio-indicator organism. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139574DOI Listing

Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats.

Biomed Pharmacother 2020 Jun 1;128:110304. Epub 2020 Jun 1.

Department of Pharmacology, Guangdong Medical University, Zhanjiang, Guangdong, 524023, PR China. Electronic address:

Background And Aims: Aging-induced bone loss is a multifactorial, age-related, and progressive phenomenon among the general population and may further progress to osteoporosis and increase the risk of fractures. Cycloastragenol (CAG), currently the only compound reported that activates human telomerase, is thought to be able to alleviate or delay the symptoms of aging and chronic diseases. Previous research has suggested that CAG may have the potential to alleviate age-related bone loss. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110304DOI Listing

Perfluorinated compounds are not necessary: pegylated organosilanes can endow good water sliding/removal properties.

J Hazard Mater 2020 May 18;398:122625. Epub 2020 May 18.

National Institute of Advanced Industrial Science and Technology (AIST), 2266-98, Anagahora, Shimo-shidami, Moriyama, Nagoya 463-8560, Japan. Electronic address:

From a viewpoint of reducing the burden on both human health and the environment, alternative surface modification techniques for preparing highly water-repellent surfaces without the use of environmentally damaging perfluorocarbons are highly desirable. Among them, the development of hydrophilic surfaces showing superior water sliding/removal properties has been scarcely reported. In this study, we have successfully demonstrated the fabrication of smooth, transparent, and hydrophilic pegylated organosilanes (PEG-Si, CHO-(CHO)-CH-Si(OCH) where n = 3, 6-9, 9-12)-derived hybrid films showing excellent water sliding/removal properties using a simple sol-gel reaction of PEG-Si and tetraethoxysilane (TEOS, Si(OCH)). Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122625DOI Listing

Effect of groundwater ions (Ca, Na, and HCO) on removal of hexavalent chromium by Fe(II)-phosphate mineral.

J Hazard Mater 2020 May 25;398:122948. Epub 2020 May 25.

Department of Civil and Environmental Engineering, Green Environment and Energy Lab., National Laboratory Astana, Nazarbayev University, Nur-Sultan 010000, Kazakhstan. Electronic address:

A systematic study was conducted to investigate the effect of major groundwater ions (i.e., Ca, Na, and HCO) on removal of hexavalent chromium (Cr(VI)) by an Fe(II)-phosphate mineral (i. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122948DOI Listing

Effect of the Wet Market on the coronavirus disease (COVID-19) transmission dynamics in China, 2019-2020.

Int J Infect Dis 2020 Jun 1. Epub 2020 Jun 1.

Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, USA.

Objectives: The novel coronavirus (SARS-CoV-2) originating from Wuhan rapidly spread throughout China. While its origin remains uncertain, accumulating evidence links a wet market for the early SARS-CoV-2 spread in Wuhan. Similarly, the influence of the marketplace on the early transmission dynamics is yet to be investigated. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.091DOI Listing

A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy.

Cell Mol Gastroenterol Hepatol 2020 Jun 1. Epub 2020 Jun 1.

Inflammatory Bowel Diseases Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Queensland 4102, Australia; Inflammatory Disease Biology and Therapeutics Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Queensland 4102, Australia; School of Medicine, Faculty of Medicine, University of Queensland. Electronic address:

Background & Aims: Chronic bowel inflammation increases the risk of colon cancer: colitis associated cancer (CAC). Thiopurine use is associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin signalling is characteristic of >90% of colorectal cancers. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2020.05.012DOI Listing

A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction.

Brain Behav Immun 2020 Jun 1. Epub 2020 Jun 1.

University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group. Electronic address:

The SARS-CoV-2 virus infects cells of the airway and lungs in humans causing the disease COVID-19. This disease is characterized by cough, shortness of breath, and in severe cases causes pneumonia and acute respiratory distress syndrome (ARDS) which can be fatal. Bronchial alveolar lavage fluid (BALF) and plasma from mild and severe cases of COVID-19 have been profiled using protein measurements and bulk and single cell RNA sequencing. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.05.078DOI Listing

An experimental and algorithm-based study of the spectral features of breast cancer patients by a photodiagnosis approach.

Photodiagnosis Photodyn Ther 2020 Jun 1:101851. Epub 2020 Jun 1.

Department of Electrical Computer Engineering, COMSATS University Islambad, Islamabad Campus, Park Road, Chak Shahzad, Islamabad, 45550, Pakistan.

In the present study, the spectral diagnosis of blood plasma samples of breast cancer patients and an equal number of normal controls was investigated. A set of ratio parameters was acquired by employing SXS and FES. The samples were also analyzed statistically by employing Welch two-sample t-tests, and the effects of three ratio parameters, R, R, and R, were also studied by plotting them against the subject numbers. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101851DOI Listing

Automatic Human Dendritic Cells Segmentation Using K-Means Clustering and Chan-Vese Active Contour Model.

Comput Methods Programs Biomed 2020 May 22;195:105520. Epub 2020 May 22.

ESIAB, LUBEM, 29280, Plouzané, France.

Background And Objective: Nowadays, the number of pathologies related to food are multiplied. Mycotoxins are one of the most severe food contaminants that cause serious effects on the human health. Therefore, it is necessary to develop an assessment tool for evaluating their impact on the immune response. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105520DOI Listing

PRIMARY LEIOMYOSARCOMA OF THE OVARY: A REPORT OF THREE CASES AND A SYSTEMATIC REVIEW OF LITERATURE.

J Gynecol Obstet Hum Reprod 2020 Jun 1:101825. Epub 2020 Jun 1.

Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Clinic, Health Sciences University, Turkey. Electronic address:

Primary ovarian leiomyosarcomas (POLMs) comprise <0.1% of all ovarian malignancies. Here we aimed to define the clinical, surgical, and pathological features, as well as the oncologic outcome, of POLM. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101825DOI Listing

Cardiac Irradiation Predicts Activity Decline in Patients Receiving Concurrent Chemoradiation for Locally Advanced Lung Cancer.

Int J Radiat Oncol Biol Phys 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiation Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York. Electronic address:

Purpose: Many lung cancer patients are inactive due to their disease and underlying comorbidities, and activity levels can decline further during cancer therapy. Here we explore dosimetric predictors of activity decline in a cohort of patients who underwent continuous activity monitoring during definitive concurrent chemoradiotherapy (CRT) for locally advanced lung cancer.

Methods And Materials: We identified patients who participated in prospective clinical trials involving the use of a commercial fitness tracker throughout the course of CRT. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.05.042DOI Listing

Development of laboratory-scale sequential electrokinetic and biological treatment of chronically hydrocarbon-impacted soils.

N Biotechnol 2020 Jun 1. Epub 2020 Jun 1.

Department for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), University of Tuscia, Via S. Camillo De Lellis, 00110, Viterbo, Italy.

This study focused on the remediation of a chronically diesel-polluted soil by combining an electrokinetic treatment with a variety of bioremediation approaches. Priority within the sequential treatment was given to electrokinetic remediation (EKR) since the application of natural attenuation (NA), biostimulation and site-specific bio-augmentation resulted in very low degradation performance for total petroleum hydrocarbons (TPH) and polycyclic hydrocarbons (PAH). The application of 20-day EKR (1. Read More

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http://dx.doi.org/10.1016/j.nbt.2020.04.002DOI Listing

Escherichia coli strain engineering for enhanced production of serratiopeptidase for therapeutic applications.

Int J Biol Macromol 2020 Jun 1. Epub 2020 Jun 1.

Institute of Advanced Research, Institutional area, Koba, Gandhinagar 382426, Gujarat, India. Electronic address:

Serratiopeptidase is an extracellular zinc-containing metalloprotease that is produced by Serratia marcescens having molecular weight of about 53kD. It has shown therapeutic (anti-inflammatory, anti-fibrinolytic and analgesic) as well as industrial applications (detergents, food processing, leather, paper and brewing etc.). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.256DOI Listing

Distinct residual and disordered structures of alpha-synuclein analyzed by amide-proton exchange and NMR signal intensity.

Biochim Biophys Acta Proteins Proteom 2020 Jun 1:140464. Epub 2020 Jun 1.

Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Nakano, Tokyo 164-8530, Japan; Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

The residual solution structures of two alpha-synuclein mutants, A30P and A53T, observed in family members of patients with Parkinson's disease were compared with that of wild-type by NMR. The A53T substitution had been shown to accelerate fibril formation of alpha-synuclein, whereas the A30P mutation has the negative and positive effects on the formation of the fibril and spherical oligomer, respectively. The remaining structure was analyzed via amide-proton exchange and signal intensity measurements using NMR. Read More

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http://dx.doi.org/10.1016/j.bbapap.2020.140464DOI Listing

Role of HMGB1 signaling in the inflammatory process in diabetic retinopathy.

Authors:
Jena J Steinle

Cell Signal 2020 Jun 1:109687. Epub 2020 Jun 1.

Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

High mobility group box 1 (HMGB1) is a key player in retinal inflammation. HMGB1 is a danger associated protein pattern receptor which can sense high glucose as a stressor. Increased HMGB1 levels have been found in patients with late stage diabetic retinopathy. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109687DOI Listing

2-[F]FDG PET/CT radiomics in lung cancer: an overview of the technical aspect and its emerging role in management of the disease.

Methods 2020 Jun 1. Epub 2020 Jun 1.

Department of Nuclear Medicine, University Hospital, RWTH University, Aachen, Germany; Department of Nuclear Medicine & Endocrinology, Paracelsus Medical University, Salzburg, Austria. Electronic address:

Lung cancer is the most common cancer, worldwide, and a major health issue with a remarkable mortality rate. 2-[F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (2-[F]FDG PET/CT) plays an indispensable role in the management of lung cancer patients. Long-established quantitative parameters such as size, density, and metabolic activity have been and are being employed in the current practice to enhance interpretation and improve diagnostic and prognostic value. Read More

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http://dx.doi.org/10.1016/j.ymeth.2020.05.023DOI Listing

Phylogenetic and recombinant analyses of complete coding sequences of DENV-1 from field-caught mosquitoes in Thailand.

Virus Res 2020 Jun 1:198041. Epub 2020 Jun 1.

Evolutionary Genetics and Computer Biology Research Unit, Department of Genetics, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Lat Yao District, Chatuchak, Bangkok 10900, Thailand; Centre for Advanced Studies in Tropical Natural Resources, National Research University-Kasetsart University (CASTNAR, NRU-KU, Thailand), 50 Ngam Wong Wan Road, Lat Yao District, Chatuchak, Bangkok 10900, Thailand. Electronic address:

Dengue diseases are a group of infectious diseases that have been widespread throughout the world for several decades. Dengue outbreaks have occurred in many parts of the world, including Southeast Asia. The outbreak and the severity of the diseases depend on many factors including dengue genotype. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198041DOI Listing

Intratumoral CD4 T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.

Cell 2020 Jun 3. Epub 2020 Jun 3.

Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The specific T cells that mediate tumor rejection are unknown. T cells from human bladder tumors and non-malignant tissue were assessed with single-cell RNA and paired T cell receptor (TCR) sequencing of 30,604 T cells from 7 patients. Read More

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http://dx.doi.org/10.1016/j.cell.2020.05.017DOI Listing

Tail-phase safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in HIV-uninfected adults: a secondary analysis of the HPTN 077 trial.

Lancet HIV 2020 Jun 1. Epub 2020 Jun 1.

School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Background: Long-acting injectable cabotegravir is a novel integrase inhibitor currently in advanced clinical development for HIV prevention and treatment. We aimed to assess the terminal phase pharmacokinetics and safety of long-acting injectable cabotegravir in participants included in the HPTN 077 trial.

Methods: HPTN 077 was a multicentre, double-blind, randomised, placebo-controlled phase 2a trial done at eight sites in Brazil, Malawi, South Africa, and the USA. Read More

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http://dx.doi.org/10.1016/S2352-3018(20)30106-5DOI Listing

ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization.

Dev Cell 2020 May 27. Epub 2020 May 27.

Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Japan Science and Technology Agency, PRESTO, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission is coordinated with intracellular biochemical signaling to achieve collective movements. Here, we show that intercellular coupling of extracellular signal-regulated kinase (ERK)-mediated mechanochemical feedback yields long-distance transmission of guidance cues. Read More

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http://dx.doi.org/10.1016/j.devcel.2020.05.011DOI Listing

The Psychological Change Process of Frontline Nurses Caring for Patients with COVID-19 during Its Outbreak.

Issues Ment Health Nurs 2020 Jun 4:1-6. Epub 2020 Jun 4.

Advanced Nursing Practice & Education, College of Nursing, East Carolina University Greenville, NC, USA.

To identify the psychological change process of the registered nurses who worked in the epicenter of the COVID-19 outbreak. The pandemic of COVID-19 has continued to pose an unprecedented threat and challenge to people's health around the world. Nurses are at high risk because they work within the closest proximity to patients. Read More

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http://dx.doi.org/10.1080/01612840.2020.1752865DOI Listing

Determining the steering direction in critical situations: A decision tree-based method.

Traffic Inj Prev 2020 Jun 4:1-6. Epub 2020 Jun 4.

State Key Laboratory of Automotive Safety and Energy, School of Vehicle and Mobility, Tsinghua University, Beijing, China.

Factors related to the driver-vehicle-environment system have a significant influence on a driver's decision to perform evasive maneuvers, especially the decision of steering direction (DSD) in critical situations. However, few studies have systematically investigated the relationships between these factors and DSD. The objective of this study is to analyze and model drivers' DSD in critical situations. Read More

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http://dx.doi.org/10.1080/15389588.2020.1771326DOI Listing

Fundamentals of Microscopy.

Authors:
Jeremy Sanderson

Curr Protoc Mouse Biol 2020 Jun;10(2):e76

Bioimaging Facility Manager, MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.

The light (or optical) microscope is the icon of science. The aphorism "seeing is believing" is often quoted in scientific papers involving microscopy. Unlike many scientific instruments, the light microscope will deliver an image however badly it is set up. Read More

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http://dx.doi.org/10.1002/cpmo.76DOI Listing

Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide-induced osteomyelitis-like model in MC3T3-E1, and 4B12 osteoclastogenesis.

J Cell Mol Med 2020 Jun 4. Epub 2020 Jun 4.

Department of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.

Chronic osteomyelitis, a bone infectious disease, is characterized by dysregulation of bone homeostasis, which results in excessive bone resorption. Lipopolysaccharide (LPS) which is a gram-negative endotoxin was shown to inhibit osteoblast differentiation and to induce apoptosis and osteoclasts formation in vitro. While effective therapy against bacteria-induced bone destruction is quite limited, the investigation of potential drugs that restore down-regulated osteoblast function remains a major goal in the prevention of bone destruction in infective bone diseases. Read More

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http://dx.doi.org/10.1111/jcmm.15294DOI Listing

Bioinspired Amorphous Nanoparticles of Polyphosphate and Ca-Carbonate Improve the Self-Healing Property of Cements.

Biotechnol J 2020 Jun 4:e2000101. Epub 2020 Jun 4.

ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, Mainz, 55128, Germany.

Cement is used both as a construction material and for medical applications. Previously it has been shown that the physiological polymer inorganic polyphosphate (polyP) is morphogenetically active in regeneration of skin, bone and cartilage. The present study investigates the question if this polymer is also a suitable additive to improve the self-healing capacity not only of construction cement but also of inorganic bone void fillers. Read More

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http://dx.doi.org/10.1002/biot.202000101DOI Listing

Physicians' and pharmacists' perception and practice of hospital pharmacist professional role in Egypt.

Int J Pharm Pract 2020 Jun 4. Epub 2020 Jun 4.

Hospital Pharmacist, Beni-Suef General Hospital, Beni-Suef, Egypt.

Objectives: This study aimed to investigate physicians' and pharmacists' perceptions of the importance of pharmacists' role in healthcare in Egypt, and actual delivery of these roles in practice. Identifying any differences and inconsistencies between these will inform future strategies that maximize pharmacists' professional contribution to hospital practice.

Methods: A self-administered questionnaire using a 5-point Likert scale was distributed to a convenience sample of physicians (500) and pharmacists (500) practicing in selected private or public hospitals in Egypt. Read More

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http://dx.doi.org/10.1111/ijpp.12638DOI Listing

Risk Factors for symptomatic HIV-associated Neurocognitive Disorder in adults aged 50 and over attending a HIV clinic in Tanzania.

Int J Geriatr Psychiatry 2020 Jun 4. Epub 2020 Jun 4.

Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.

Objectives: HIV-associated neurocognitive disorder (HAND), although prevalent, remains a poorly researched cause of morbidity particularly in sub-Saharan Africa (SSA). We aimed to explore risk factors for HAND in people aged 50 and over under regular follow-up at a government HIV clinic in Tanzania.

Methods: HIV positive adults aged 50 years and over were approached for recruitment at a routine HIV clinic appointment over a four-month period. Read More

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http://dx.doi.org/10.1002/gps.5357DOI Listing

Increasing Host Cellular Receptor-Angiotensin-Converting Enzyme 2 (ACE2) Expression by Coronavirus may Facilitate 2019-nCoV (or SARS-CoV-2) Infection.

J Med Virol 2020 Jun 4. Epub 2020 Jun 4.

Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

The ongoing outbreak of a new coronavirus (2019-nCoV, or SARS-CoV-2) has caused an epidemic of the acute respiratory syndrome known as COVID-19 in humans. SARS-CoV-2 rapidly spread to multiple regions of China and multiple other countries, posing a serious threat to public health. The spike (S) proteins of SARS-CoV-1 and SARS-CoV-2 may use the same host cellular receptor, angiotensin-converting enzyme 2 (ACE2), for entering into host cells. Read More

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http://dx.doi.org/10.1002/jmv.26139DOI Listing

NPC-0501 trial on the value of changing chemoradiotherapy sequence, replacing 5-fluorouracil with capecitabine, and altering fractionation for patients with advanced nasopharyngeal carcinoma.

Cancer 2020 Jun 4. Epub 2020 Jun 4.

Department of Clinical Oncology, The University of Hong Kong, Hong Kong, Hong Kong.

Background: A current recommendation for the treatment of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) is conventional fractionated radiotherapy (RT) with concurrent cisplatin followed by adjuvant cisplatin and 5-fluorouracil (PF). This randomized NPC-0501 trial evaluated the therapeutic effect of changing to an induction-concurrent sequence or accelerated-fractionation sequence, and/or replacing 5-fluorouracil with capecitabine (X).

Methods: Patients with American Joint Committee on Cancer/International Union Against Cancer stage III to stage IVB NPC initially were randomly allocated to 1 of 6 treatment arms (6-arm full-randomization cohort). Read More

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http://dx.doi.org/10.1002/cncr.32972DOI Listing

An Innovative Trauma-Informed Curriculum for Sexual Assault Care.

J Nurs Educ 2020 Jun;59(6):336-340

Background: Sexual violence is a pervasive public health concern. The American Association of Colleges of Nursing recommends that nursing education comprehensively address this topic, yet nursing schools are inconsistent in doing so.

Method: An innovative, holistic curriculum that includes didactic and simulation exercises was developed to educate nurses on a trauma-informed approach to providing care for individuals who have experienced sexual violence. Read More

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http://dx.doi.org/10.3928/01484834-20200520-07DOI Listing

Sorghum qTGW1a encodes a G-protein subunit and acts as a negative regulator of grain size.

J Exp Bot 2020 Jun 4. Epub 2020 Jun 4.

State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Key Laboratory of Creative Agriculture Ministry of Agriculture, Zhejiang, Hangzhou, China.

Grain size is a major determinant of grain yield in sorghum [Sorghum bicolor (L.) Moench] and other cereals. Over 100 quantitative trait loci (QTLs) of grain size have been identified in sorghum. Read More

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http://dx.doi.org/10.1093/jxb/eraa277DOI Listing

Tumor microenvironment immune response in pancreatic ductal adenocarcinoma patients treated with neoadjuvant therapy.

J Natl Cancer Inst 2020 Jun 4. Epub 2020 Jun 4.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Neoadjuvant FOLFIRINOX and chemoradiation have been utilized to downstage borderline and locally advanced pancreatic ductal adenocarcinoma (PDAC). Whether neoadjuvant therapy-induced tumor immune response contributes to the improved survival is unknown. Therefore, we evaluated whether neoadjuvant therapy induces an immune response towards PDAC. Read More

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http://dx.doi.org/10.1093/jnci/djaa073DOI Listing
June 2020
12.583 Impact Factor
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