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    2742 results match your criteria Advanced Drug Delivery Reviews[Journal]

    1 OF 55

    Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing.
    Adv Drug Deliv Rev 2018 Feb 12. Epub 2018 Feb 12.
    Université catholique de Louvain, Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Brussels, Belgium.
    Oxygen plays a key role in wound healing, and hypoxia is a major cause of wound healing impairment; therefore, treatments to improve hemodynamics and increase wound oxygenation are of particular interest for the treatment of chronic wounds. This article describes the roles of oxygen and angiogenesis in wound healing as well as the tools used to evaluate tissue oxygenation and perfusion and then presents a review of nanomedicines and gene therapies designed to improve perfusion and oxygenation and accelerate wound healing. Read More

    Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair.
    Adv Drug Deliv Rev 2018 Feb 6. Epub 2018 Feb 6.
    Department of Materials, Imperial College London, Exhibition Road, London SW7 2AZ, UK; Department of Bioengineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK; Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, Stockholm 17177, Sweden. Electronic address:
    All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most often culminates in scar formation. Accounting for nearly 45% of deaths in the developed world, fibrosis is a process that stands diametrically opposed to functional tissue regeneration. Read More

    Combined use of nanocarriers and physical methods for percutaneous penetration enhancement.
    Adv Drug Deliv Rev 2018 Feb 6. Epub 2018 Feb 6.
    Dermatology department, University of California, San Francisco, CA 94143-0989, USA.
    Dermal and transdermal drug delivery (due to its non-invasiveness, avoidance of the first-pass metabolism, controlling the rate of drug input over a prolonged time, etc.) have gained significant acceptance. Several methods are employed to overcome the permeability barrier of the skin, improving drug penetration into/through skin. Read More

    Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery.
    Adv Drug Deliv Rev 2018 Feb 4. Epub 2018 Feb 4.
    Section - Targeted Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands; ScarTec Therapeutics BV. Enschede, The Netherlands. Electronic address:
    Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Read More

    Fluorescence anisotropy imaging in drug discovery.
    Adv Drug Deliv Rev 2018 Feb 2. Epub 2018 Feb 2.
    Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Non-invasive measurement of drug-target engagement can provide critical insights in the molecular pharmacology of small molecule drugs. Fluorescence polarization/fluorescence anisotropy measurements are commonly employed in protein/cell screening assays. However, the expansion of such measurements to the in vivo setting has proven difficult until recently. Read More

    Polymeric microneedles for transdermal protein delivery.
    Adv Drug Deliv Rev 2018 Jan 31. Epub 2018 Jan 31.
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address:
    The intrinsic properties of therapeutic proteins generally present a major impediment for transdermal delivery, including their relatively large molecule size and susceptibility to degradation. One solution is to utilize microneedles (MNs), which are capable of painlessly traversing the stratum corneum and directly translocating protein drugs into the systematic circulation. MNs can be designed to incorporate appropriate structural materials as well as therapeutics or formulations with tailored physicochemical properties. Read More

    Extracellular vesicles as modulators of wound healing.
    Adv Drug Deliv Rev 2018 Jan 31. Epub 2018 Jan 31.
    Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland; CÚRAM Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland. Electronic address:
    Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been investigated with evidence that secreted factors are responsible for the observed therapeutic benefits. This review addresses current evidence in support of stem/progenitor cell-derived extracellular vesicles (EVs) as a regenerative therapy for acceleration of wound healing. Read More

    Enhancing patient-level clinical data access to promote evidence-based practice and incentivize therapeutic innovation.
    Adv Drug Deliv Rev 2018 Jan 31. Epub 2018 Jan 31.
    Berlin-Brandenburg, Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany. Electronic address:
    Clinical trials are crucial to determining the human safety and efficacy of new therapeutic innovations. Extraordinary amounts of human experiential data are generated over the course of any clinical trial, however, much of these data is never made publicly accessible. Improved, reliable data sharing is essential to inform clinical decisions and incentivize further therapeutic improvements; this need, and the call and concept to enhance patient-level clinical trial data accessibility is not new. Read More

    MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis.
    Adv Drug Deliv Rev 2018 Jan 31. Epub 2018 Jan 31.
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:
    Non-alcoholic fatty liver disease (NAFLD) increases the risk of various liver injuries, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and ultimately hepatocellular carcinoma (HCC). Ample evidence has suggested that aberrant expression of microRNAs (miRNAs) is functionally involved in the activation of cellular stress, inflammation and fibrogenesis in hepatic cells, including hepatocytes, Kupffer and hepatic stellate cells (HSCs), at different pathological stages of NAFLD and liver fibrosis. Here, we overview recent findings on the potential role of miRNAs in the pathogenesis of NAFLD, including lipotoxicity, oxidative stress, metabolic inflammation and fibrogenesis. Read More

    Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction.
    Adv Drug Deliv Rev 2018 Jan 31. Epub 2018 Jan 31.
    Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address:
    Subcutaneous long-acting release (LAR) formulations have been extensively developed in the clinic to increase patient compliance and reduce treatment cost. Despite preliminary success for some LAR systems, a major obstacle limiting the therapeutic effect remains on their interaction with surrounding tissues. In this review, we summarize how living bodies respond to injected or implanted materials, and highlight some typical strategies based on smart material design, which may significantly improve long-term subcutaneous drug delivery. Read More

    Clinical utility of non-EpCAM based circulating tumor cell assays.
    Adv Drug Deliv Rev 2018 Jan 31. Epub 2018 Jan 31.
    Division of Medical Oncology, Department of Medicine, Duke Cancer Institute, Duke University Medical Center, United States. Electronic address:
    Methods enabling the isolation, detection, and characterization of circulating tumor cells (CTCs) in blood have clear potential to facilitate precision medicine approaches in patients with cancer, not only for prognostic purposes but also for prediction of the benefits of specific therapies in oncology. However, current CTC assays, which capture CTCs based on expression of epithelial cell adhesion molecule (EpCAM), fail to capture cells from de-differentiated tumors and carcinomas undergoing loss of the epithelial phenotype during the invasion/metastatic process. To address this limitation, many groups are developing non-EpCAM based CTC assays that incorporate nanotechnology to improve test sensitivity for rare but important cells that may otherwise go undetected, and therefore may improve upon clinical utility. Read More

    Delivery of cellular factors to regulate bone healing.
    Adv Drug Deliv Rev 2018 Jan 21. Epub 2018 Jan 21.
    Department of Biomedicine, University Hospital Basel, University of Basel, Switzerland; Department of Biomedical Engineering, University of Basel, Switzerland. Electronic address:
    Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative strategies to enhance bone repair, including the delivery of osteoprogenitor cells or of potent cytokines/morphogens, indicate the potential of 'orthobiologics', but are not fully satisfactory. Read More

    Clinical applications of the CellSearch platform in cancer patients.
    Adv Drug Deliv Rev 2018 Jan 17. Epub 2018 Jan 17.
    Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:
    The CellSearch® system (CS) enables standardized enrichment and enumeration of circulating tumor cells (CTCs) that are repeatedly assessable via non-invasive "liquid biopsy". While the association of CTCs with poor clinical outcome for cancer patients has clearly been demonstrated in numerous clinical studies, utilizing CTCs for the identification of therapeutic targets, stratification of patients for targeted therapies and uncovering mechanisms of resistance is still under investigation. Here, we comprehensively review the current benefits and drawbacks of clinical CTC analyses for patients with metastatic and non-metastatic tumors. Read More

    Ocular translational science: A review of development steps and paths.
    Adv Drug Deliv Rev 2018 Jan 31. Epub 2018 Jan 31.
    EyeGate Pharmaceuticals Inc., Waltham, MA, United States; Moran Eye Center, University of Utah, Salt Lake City, UT, United States. Electronic address:
    Developing successful drug delivery methods is challenging for any tissue, and the eye is no exception. Translating initial concepts into advanced technologies treating diseases in preclinical models and finally into functional and marketable products for humans can be particularly daunting. While referring to specific ophthalmic companies and products, this review considers key exchanges that lead to successful translation. Read More

    Wound healing in the eye: Therapeutic prospects.
    Adv Drug Deliv Rev 2018 Jan 20. Epub 2018 Jan 20.
    University of Auckland, Department of Ophthalmology, New Zealand National Eye Centre, New Zealand. Electronic address:
    In order to maintain a smooth optical surface the corneal epithelium has to continuously renew itself so as to maintain its function as a barrier to fluctuating external surroundings and various environmental insults. After trauma, the cornea typically re-epithelializes promptly thereby minimizing the risk of infection, opacification or perforation. A persistent epithelial defect (PED) is usually referred to as a non-healing epithelial lesion after approximately two weeks of treatment with standard therapies to no avail. Read More

    Microspheres as intraocular therapeutic tools in chronic diseases of the optic nerve and retina.
    Adv Drug Deliv Rev 2018 Jan 12. Epub 2018 Jan 12.
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Complutense University of Madrid, Spain; Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Madrid, Spain; Ocular Pathology National Net (OFTARED) of the Institute of Health Carlos III, Spain; Instituto Universitario de Farmacia Industrial (IUFI), School of Pharmacy, Complutense University of Madrid, Spain. Electronic address:
    Pathologies affecting the optic nerve and the retina are one of the major causes of blindness. These diseases include age-related macular degeneration (AMD), diabetic retinopathy (DR) and glaucoma, among others. Also, there are genetic disorders that affect the retina causing visual impairment. Read More

    Ocular delivery of proteins and peptides: Challenges and novel formulation approaches.
    Adv Drug Deliv Rev 2018 Jan 13. Epub 2018 Jan 13.
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA. Electronic address:
    The impact of proteins and peptides on the treatment of various conditions including ocular diseases over the past few decades has been advanced by substantial breakthroughs in structural biochemistry, genetic engineering, formulation and delivery approaches. Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to their large size, poor permeation and susceptibility to degradation. A wide range of advanced drug delivery systems including polymeric controlled release systems, cell-based delivery and nanowafers are being exploited to overcome the challenges of frequent administration to ocular tissues. Read More

    Addressing barriers to effective cancer immunotherapy with nanotechnology: achievements, challenges, and roadmap to the next generation of nanoimmunotherapeutics.
    Adv Drug Deliv Rev 2018 Jan 12. Epub 2018 Jan 12.
    Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702. Electronic address:
    Cancer is a complex systemic disorder that affects many organs and tissues and arises from the altered function of multiple cellular and molecular mechanisms. One of the systems malfunctioning in cancer is the immune system. Restoring and improving the ability of the immune system to effectively recognize and eradicate cancer is the main focus of immunotherapy, a topic which has garnered recent and significant interest. Read More

    Multifunctional hybrid graphene oxide for circulating tumor cell isolation and analysis.
    Adv Drug Deliv Rev 2018 Jan 10. Epub 2018 Jan 10.
    Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA. Electronic address:
    Even in 21st century, >90% cancer-associated deaths are caused by metastatic disease. Circulating tumor cells (CTCs), which circulate in the blood stream after release from primary tumors, extravasate and form fatal metastases in different organs. Several clinical trials indicate that CTCs can be used as a liquid biopsy of tumors for early diagnosis of cancers. Read More

    Size-based separation methods of circulating tumor cells.
    Adv Drug Deliv Rev 2018 Jan 8. Epub 2018 Jan 8.
    Department of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, USA; Penn State Materials Research Institute, The Pennsylvania State University, University Park, PA 16802, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA; Department of Electrical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; Penn State Hershey Cancer Institute, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. Electronic address:
    Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the peripheral bloodstream. Compared to other "liquid biopsy" portfolios such as exosome, circulating tumor DNA/RNA (ctDNA/RNA), CTCs have incomparable advantages in analyses of transcriptomics, proteomics, and signal colocalization. Hence, CTCs hold the key to understanding the biology of metastasis and play a vital role in cancer diagnosis, treatment monitoring, and prognosis. Read More

    Molecular analysis of circulating tumors cells: Biomarkers beyond enumeration.
    Adv Drug Deliv Rev 2018 Jan 8. Epub 2018 Jan 8.
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, United States; Massachusetts General Hospital Cancer Center, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address:
    Advances in our molecular understanding of cancer biology have paved the way to an expanding compendium of molecularly-targeted therapies, accompanied by the urgent need for biomarkers that enable the precise selection of the most appropriate therapies for individual cancer patients. Circulating biomarkers such as circulating tumor cells (CTCs) are poised to fill this need, since they are "liquid biopsies" that can be performed non-invasively and serially, and may capture the spectrum of spatial and temporal tumor heterogeneity better than conventional tissue biopsies. Increasing evidence suggests that moving beyond the enumeration of CTCs towards more sophisticated molecular analyses can provide actionable data that may predict and potentially improve clinical outcomes. Read More

    Co association of mucus modulating agents and nanoparticles for mucosal drug delivery.
    Adv Drug Deliv Rev 2018 Jan 4;124:175-183. Epub 2018 Jan 4.
    NOBIPOL, Department of Biotechnology and Food Science, Norwegian University of Science and Technology NTNU, 7491 Trondheim, Norway. Electronic address:
    Nanoparticulate drug delivery systems (nDDS) offer a variety of options when it comes to routes of administration. One possible path is crossing mucosal barriers, such as in the airways and in the GI tract, for systemic distribution or local treatment. The main challenge with this administration route is that the size and surface properties of the nanoparticles, as opposed to small molecular drugs, very often results in mucosal capture, immobilization and removal, which in turn results in a very low bioavailability. Read More

    Ophthalmic gels: Past, present and future.
    Adv Drug Deliv Rev 2017 Dec 27. Epub 2017 Dec 27.
    Drug Discovery, Delivery and Patient Care (DDDPC) Research Theme, Kingston University London, School of Life Sciences, Pharmacy and Chemistry, Kingston Upon Thames KT1 2EE, UK; School of Pharmacy, The University of Auckland, Auckland, New Zealand. Electronic address:
    Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based ones with intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes. Read More

    Blood derivatives awaken in regenerative medicine strategies to modulate wound healing.
    Adv Drug Deliv Rev 2017 Dec 28. Epub 2017 Dec 28.
    3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's-PT Associated Laboratory, 4805-017 Braga/Guimarães, Portugal; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal. Electronic address:
    Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awakened as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms. Read More

    Targeting renal fibrosis: Mechanisms and drug delivery systems.
    Adv Drug Deliv Rev 2017 Dec 27. Epub 2017 Dec 27.
    Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address:
    Renal fibrosis is the common outcome of many chronic kidney diseases (CKD) independent of the underlying etiology. Despite a host of promising experimental data, currently available strategies only ameliorate or delay the progression of CKD but do not reverse fibrosis. One of the major impediments of translating novel antifibrotic strategies from bench to bedside is due to the intricacies of the drug delivery process. Read More

    Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing.
    Adv Drug Deliv Rev 2017 Dec 24. Epub 2017 Dec 24.
    Experimental Trauma Surgery, Department of Trauma Surgery, University Medical Centre Regensburg, Regensburg, Germany. Electronic address:
    Due to the increasing age of our society and a rise in engagement of young people in extreme and/or competitive sports, both tendinopathies and tendon ruptures present a clinical and financial challenge. Tendon has limited natural healing capacity and often responds poorly to treatments, hence it requires prolonged rehabilitation in most cases. Till today, none of the therapeutic options has provided successful long-term solutions, meaning that repaired tendons do not recover their complete strength and functionality. Read More

    Microfluidics for producing poly (lactic-co-glycolic acid)-based pharmaceutical nanoparticles.
    Adv Drug Deliv Rev 2017 Dec 24. Epub 2017 Dec 24.
    CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, No. 11 Zhongguancun Beiyitiao, Beijing 100190, PR China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, No. 11 Zhongguancun Beiyitiao, Beijing 100190, PR China; CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing 100190, PR China; University of Chinese Academy of Sciences, 19 A Yuquan Road, Shijingshan District, Beijing, 100049, PR China. Electronic address:
    Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods. The batch-to-batch reproducibility which is essential for clinical translation is achieved by precisely controlling the precursors and the flow rate, regardless of operators. Poly (lactic-co-glycolic acid) (PLGA) is the most widely used Food and Drug Administration (FDA)-approved biodegradable polymers. Read More

    miRNA delivery for skin wound healing.
    Adv Drug Deliv Rev 2017 Dec 19. Epub 2017 Dec 19.
    Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Ireland. Electronic address:
    The wound healing has remained a worldwide challenge as one of significant public health problems. Pathological scars and chronic wounds caused by injury, aging or diabetes lead to impaired tissue repair and regeneration. Due to the unique biological wound environment, the wound healing is a highly complicated process, efficient and targeted treatments are still lacking. Read More

    Current and future technological advances in transdermal gene delivery.
    Adv Drug Deliv Rev 2017 Dec 19. Epub 2017 Dec 19.
    School of Engineering, Institute for Bioengineering, The University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JL, United Kingdom. Electronic address:
    Transdermal gene delivery holds significant advantages as it is able to minimize the problems of systemic administration such as enzymatic degradation, systemic toxicity, and poor delivery to target tissues. This technology has the potential to transform the treatment and prevention of a range of diseases. However, the skin poses a great barrier for gene delivery because of the "bricks-and-mortar" structure of the stratum corneum and the tight junctions between keratinocytes in the epidermis. Read More

    Engineered cell and tissue models of pulmonary fibrosis.
    Adv Drug Deliv Rev 2017 Dec 18. Epub 2017 Dec 18.
    Department of Biomedical Engineering, Tufts University, Medford, MA, United States. Electronic address:
    Pulmonary fibrosis includes several lung disorders characterized by scar formation and Idiopathic Pulmonary Fibrosis (IPF) is a particularly severe form of pulmonary fibrosis of unknown etiology with a mean life expectancy of 3years' post-diagnosis. Treatments for IPF are limited to two FDA approved drugs, pirfenidone and nintedanib. Most lead candidate drugs that are identified in pre-clinical animal studies fail in human clinical trials. Read More

    Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration.
    Adv Drug Deliv Rev 2017 Dec 17. Epub 2017 Dec 17.
    School of Materials, The University of Manchester, Manchester M13 9PL, UK. Electronic address:
    Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment. Read More

    Functional therapies for cutaneous wound repair in epidermolysis bullosa.
    Adv Drug Deliv Rev 2017 Dec 15. Epub 2017 Dec 15.
    EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University, Salzburg, Austria. Electronic address:
    Chronic wounding as a result of recurrent skin blistering in the painful genetic skin disease epidermolysis bullosa, may lead to life-threatening infections, increased risk of tumor formation, and other serious medical complications. Therefore, epidermolysis bullosa patients have an urgent need for optimal wound care and tissue regeneration. Therapeutic strategies using gene-, protein-, and cell-therapies are being developed to improve clinical symptoms, and some of them have already been investigated in early clinical trials. Read More

    Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics.
    Adv Drug Deliv Rev 2017 Dec 14. Epub 2017 Dec 14.
    Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Ghent, Belgium. Electronic address:
    With the dramatic consequences of bacterial resistance to antibiotics, nanomaterials and molecular transporters have started to be investigated as alternative antibacterials or anti-infective carrier systems to improve the internalization of bactericidal drugs. However, the capability of nanomaterials/molecular transporters to overcome the bacterial cell envelope is poorly understood. It is critical to consider the sophisticated architecture of bacterial envelopes and reflect how nanomaterials/molecular transporters can interact with these envelopes, being the major aim of this review. Read More

    Expression, activity and pharmacokinetic impact of ocular transporters.
    Adv Drug Deliv Rev 2017 Dec 14. Epub 2017 Dec 14.
    Centre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland. Electronic address:
    The eye is protected by several tissues that limit the permeability and entry of potentially harmful substances, but also hamper the delivery of drugs in the treatment of ocular diseases. Active transport across the ocular barriers may affect drug distribution, but the impact of drug transporters on ocular drug delivery is not well known. We have collected and critically reviewed the literature for ocular expression and activity of known drug transporters. Read More

    Implications of melanin binding in ocular drug delivery.
    Adv Drug Deliv Rev 2017 Dec 13. Epub 2017 Dec 13.
    School of Pharmacy, University of Eastern Finland, Kuopio, Finland. Electronic address:
    Pigmented ocular tissues contain melanin within the intracellular melanosomes. Drugs bind to melanin at varying extent that ranges from no binding to extensive binding. Binding may lead to drug accumulation to the pigmented tissues and prolonged drug retention in the melanin containing cells. Read More

    Fibrin-based delivery strategies for acute and chronic wound healing.
    Adv Drug Deliv Rev 2017 Dec 13. Epub 2017 Dec 13.
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
    Fibrin, a natural hydrogel, is the end product of the physiological blood coagulation cascade and naturally involved in wound healing. Beyond its role in hemostasis, it acts as a local reservoir for growth factors and as a provisional matrix for invading cells that drive the regenerative process. Its unique intrinsic features do not only promote wound healing directly via modulation of cell behavior but it can also be fine-tuned to evolve into a delivery system for sustained release of therapeutic biomolecules, cells and gene vectors. Read More

    Integration of biomimicry and nanotechnology for significantly improved detection of circulating tumor cells (CTCs).
    Adv Drug Deliv Rev 2017 Dec 13. Epub 2017 Dec 13.
    Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, WI 53705, United States; Division of Integrated Science and Engineering, Underwood International College, Yonsei University, Seoul 03706, Republic of Korea. Electronic address:
    Circulating tumor cells (CTCs) have received a great deal of scientific and clinical attention as a biomarker for diagnosis and prognosis of many types of cancer. Given their potential significance in clinics, a variety of detection methods, utilizing the recent advances in nanotechnology and microfluidics, have been introduced in an effort of achieving clinically significant detection of CTCs. However, effective detection and isolation of CTCs still remain a tremendous challenge due to their extreme rarity and phenotypic heterogeneity. Read More

    Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems.
    Adv Drug Deliv Rev 2018 Jan 13;124:184-192. Epub 2017 Dec 13.
    Institute of Cell & Molecular Biosciences, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.. Electronic address:
    Drug delivery to the mucus covered mucosae is fraught with difficulties and many different approaches have been developed to permeate the mucus barrier. Generally by modifying the delivery system to avoid interaction with the mucus. These modifications are reviewed here in terms of efficacy and safety. Read More

    Nanoplasmonic sensors for detecting circulating cancer biomarkers.
    Adv Drug Deliv Rev 2017 Dec 14. Epub 2017 Dec 14.
    School of Chemical Engineering, Sungkyunkwan University, 16419, Republic of Korea. Electronic address:
    The detection of cancer biomarkers represents an important aspect of cancer diagnosis and prognosis. Recently, the concept of liquid biopsy has been introduced whereby diagnosis and prognosis are performed by means of analyzing biological fluids obtained from patients to detect and quantify circulating cancer biomarkers. Unlike conventional biopsy whereby primary tumor cells are analyzed, liquid biopsy enables the detection of a wide variety of circulating cancer biomarkers, including microRNA (miRNA), circulating tumor DNA (ctDNA), proteins, exosomes and circulating tumor cells (CTCs). Read More

    Technological strategies to estimate and control diffusive passage times through the mucus barrier in mucosal drug delivery.
    Adv Drug Deliv Rev 2018 Jan 12;124:64-81. Epub 2017 Dec 12.
    Department of Mathematics and Applied Physical Sciences, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, United States; UNC-NCSU Joint Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address:
    In mucosal drug delivery, two design goals are desirable: 1) insure drug passage through the mucosal barrier to the epithelium prior to drug removal from the respective organ via mucus clearance; and 2) design carrier particles to achieve a prescribed arrival time and drug uptake schedule at the epithelium. Both goals are achievable if one can control "one-sided" diffusive passage times of drug carrier particles: from deposition at the mucus interface, through the mucosal barrier, to the epithelium. The passage time distribution must be, with high confidence, shorter than the timescales of mucus clearance to maximize drug uptake. Read More

    Drug delivery and tissue engineering to promote wound healing in the immunocompromised host: Current challenges and future directions.
    Adv Drug Deliv Rev 2017 Dec 6. Epub 2017 Dec 6.
    Department of Bioengineering, Rice University, Houston, TX, United States. Electronic address:
    As regenerative medicine matures as a field, more promising technologies are being translated from the benchtop to the clinic. However, many of these strategies are designed with otherwise healthy hosts in mind and validated in animal models without other co-morbidities. In reality, many of the patient populations benefiting from drug delivery and tissue engineering-based devices to enhance wound healing also have significant underlying immunodeficiency. Read More

    Pulmonary drug delivery to older people.
    Adv Drug Deliv Rev 2017 Nov 29. Epub 2017 Nov 29.
    Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, NSW 2006, Australia. Electronic address:
    Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Read More

    Bench-to-bedside translation of dendrimers: Reality or utopia? A concise analysis.
    Adv Drug Deliv Rev 2017 Nov 16. Epub 2017 Nov 16.
    Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, BP, 44099, 31077 Toulouse Cedex 4, France; Université de Toulouse, UPS, INPT, 31077 Toulouse Cedex, France. Electronic address:
    Nanomedicine, which is an application of nanotechnologies in healthcare is developed to improve the treatments and lives of patients suffering from a range of disorders and to increase the successes of drug candidates. Within the nanotechnology universe, the remarkable unique and tunable properties of dendrimers have made them promising tools for diverse biomedical applications such as drug delivery, gene therapy and diagnostic. Up-to-date, very few dendrimers has yet gained regulatory approval for systemic administration, why? In this critical review, we briefly focus on the list of desired basic dendrimer requirements for decision-making purpose by the scientists (go/no-go decision), in early development stages, to become clinical candidates, and to move towards Investigational New Drugs (IND) application submission. Read More

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