2,915 results match your criteria Advanced Drug Delivery Reviews[Journal]


Rationally designed DNA-based nanocarriers.

Adv Drug Deliv Rev 2019 Feb 12. Epub 2019 Feb 12.

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Nanomaterials employed for enhanced drug delivery and therapeutic effects have been extensively investigated in the past decade. The outcome of current anticancer treatments based on conventional nanoparticles is suboptimal, due to the lack of biocompatibility, the deficient tumor targeting, the limited drug accumulation in the diseased region, etc. Alternatively, DNA-based nanocarriers have emerged as a novel and versatile platform to integrate the advantages of nanotechnologies and biological sciences, which shows great promise in addressing the key issues for biomedical studies. Read More

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February 2019

Let's get small (and smaller): Combining zebrafish and nanomedicine to advance neuroregenerative therapeutics.

Adv Drug Deliv Rev 2019 Feb 12. Epub 2019 Feb 12.

Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA. Electronic address:

Several key attributes of zebrafish make them an ideal model system for the discovery and development of regeneration promoting therapeutics; most notably their robust capacity for self-repair which extends to the central nervous system. Further, by enabling large-scale drug discovery directly in living vertebrate disease models, zebrafish circumvent critical bottlenecks which have driven drug development costs up. This review summarizes currently available zebrafish phenotypic screening platforms, HTS-ready neurodegenerative disease modeling strategies, zebrafish small molecule screens which have succeeded in identifying regeneration promoting compounds and explores how intravital imaging in zebrafish can facilitate comprehensive analysis of nanocarrier biodistribution and pharmacokinetics. Read More

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http://dx.doi.org/10.1016/j.addr.2019.01.011DOI Listing
February 2019

A minimalist's approach for DNA nanoconstructions.

Authors:
Hua Zuo Chengde Mao

Adv Drug Deliv Rev 2019 Feb 12. Epub 2019 Feb 12.

Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; Chemistry Department, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

Structural DNA nanotechnology takes DNA, a biopolymer, far beyond being the molecule that stores and transmits genetic information in biological systems. DNA has been employed as building blocks for the assembly of designed, nanoscaled, supramolecular DNA architectures for applications in biophysics, structure determination, synthetic biology, diagnostics, and drug delivery. Herein, we review a symmetric approach of tile-based DNA self-assembly. Read More

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http://dx.doi.org/10.1016/j.addr.2019.02.002DOI Listing
February 2019

Therapeutic gene regulation using pyrrole-imidazole polyamides.

Adv Drug Deliv Rev 2019 Feb 8. Epub 2019 Feb 8.

Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomaecho, Sakyo-Ku, Kyoto 606-8501, Japan. Electronic address:

Recent innovations in cutting-edge sequencing platforms have allowed the rapid identification of genes associated with communicable, noncommunicable and rare diseases. Exploitation of this collected biological information has facilitated the development of nonviral gene therapy strategies and the design of several proteins capable of editing specific DNA sequences for disease control. Small molecule-based targeted therapeutic approaches have gained increasing attention because of their suggested clinical benefits, ease of control and lower costs. Read More

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February 2019

Nanotechnology in cell replacement therapies for type 1 diabetes.

Adv Drug Deliv Rev 2019 Feb 2. Epub 2019 Feb 2.

Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA. Electronic address:

Islet transplantation is a promising long-term, compliance-free, complication-preventing treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow set of patients due to the shortage of donor islets and side effects from immunosuppression. Encapsulating cells in an immunoisolating membrane can allow for their transplantation without the need for immunosuppression. Read More

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February 2019
1 Read

A window into the brain: Tools to assess preclinical efficacy of biomaterials-based therapies on central nervous system disorders.

Adv Drug Deliv Rev 2019 Jan 30. Epub 2019 Jan 30.

CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland. Electronic address:

Therapeutic conveyance into the brain is a cardinal requirement for treatment of diverse central nervous system (CNS) disorders and associated pathophysiology. Effectual shielding of the brain by the blood-brain barrier (BBB) sieves out major proportion of therapeutics with the exception of small lipophilic molecules. Various nano-delivery systems (NDS) provide an effective solution around this obstacle owing to their small size and targeting properties. Read More

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http://dx.doi.org/10.1016/j.addr.2019.01.012DOI Listing
January 2019
2 Reads

Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases.

Adv Drug Deliv Rev 2019 Jan 25. Epub 2019 Jan 25.

Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IIIM, Jammu Campus, Jammu 180001, India. Electronic address:

Cathepsins are an important category of enzymes that have attracted great attention for the delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug delivery systems. These proteases can be utilized for instance through actuation of polymer-drug conjugates (e.g. Read More

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January 2019
3 Reads

Bridging the gaps between academic research and industrial product developments of lipid-based formulations.

Authors:
René Holm

Adv Drug Deliv Rev 2019 Jan 22. Epub 2019 Jan 22.

Drug Product Development, Janssen R&D, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium; Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark. Electronic address:

Lipid-based formulations, including self-emulsifying drug delivery systems (SEDDS), are an interesting formulation technology that enables the clinical use of compounds for which a low aqueous solubility may be a limitation. From an academic perspective, the technology is interesting on several levels: what drives solubility, what determines bioperformance, what is the potential for solidification etc. From an industrial perspective, >35 lipid-based formulations are available and there is an unknown number of projects in the pipeline. Read More

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http://dx.doi.org/10.1016/j.addr.2019.01.009DOI Listing
January 2019

Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs.

Adv Drug Deliv Rev 2019 Jan 21. Epub 2019 Jan 21.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia.. Electronic address:

Self-dispersing lipid-based formulations, particularly self-microemulsifying drug delivery systems (SMEDDS) have gained an increased interest in recent times as a means to enhance the oral bioavailability of poorly water-soluble lipophilic drugs. Upon dilution, SMEDDS self-emulsify in an aqueous fluid and usually form a kinetically stable oil-in-water emulsion or in some rare cases a true thermodynamically stable microemulsion. The digestion of the formulation leads to the production of amphiphilic digestion products that interact with endogenous amphiphilic components and form self-assembled colloidal phases in the aqueous environment of the intestine. Read More

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January 2019
1 Read

Bacteriophage interactions with mammalian tissue: Therapeutic applications.

Adv Drug Deliv Rev 2019 Jan 17. Epub 2019 Jan 17.

School of Pharmacy, University of Waterloo, 10A Victoria St S, Kitchener N2G 1C5, Canada. Electronic address:

The human body is a large reservoir for bacterial viruses known as bacteriophages (phages), which participate in dynamic interactions with their bacterial and human hosts that ultimately affect human health. The current growing interest in human resident phages is paralleled by new uses of phages, including the design of engineered phages for therapeutic applications. Despite the increasing number of clinical trials being conducted, the understanding of the interaction of phages and mammalian cells and tissues is still largely unknown. Read More

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http://dx.doi.org/10.1016/j.addr.2019.01.003DOI Listing
January 2019
2 Reads

T-cells "à la CAR-T(e)" - Genetically engineering T-cell response against cancer.

Adv Drug Deliv Rev 2019 Jan 14. Epub 2019 Jan 14.

The Laboratory of Tumor Immunology and Immunotherapy, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900-02, Israel. Electronic address:

The last decade will be remembered as the dawn of the immunotherapy era during which we have witnessed the approval by regulatory agencies of genetically engineered CAR T-cells and of checkpoint inhibitors for cancer treatment. Understandably, T-lymphocytes represent the essential player in these approaches. These cells can mediate impressive tumor regression in terminally-ill cancer patients. Read More

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January 2019
8 Reads

Thermally-triggered fabrication of cell sheets for tissue engineering and regenerative medicine.

Adv Drug Deliv Rev 2019 Jan 11. Epub 2019 Jan 11.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Cell transplantation is a promising approach for promoting tissue regeneration in the treatment of damaged tissues or organs. Although cells have conventionally been delivered by direct injection to damaged tissues, cell injection has limited efficiency to deliver therapeutic cells to the target sites. Progress in tissue engineering has moved scaffold-based cell/tissue delivery into the mainstream of tissue regeneration. Read More

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http://dx.doi.org/10.1016/j.addr.2019.01.004DOI Listing
January 2019
1 Read

Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers.

Adv Drug Deliv Rev 2019 Jan 11. Epub 2019 Jan 11.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute of Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. Electronic address:

Over the years, a plethora of materials - natural and synthetic - have been engineered at a nanoscopic level and explored for drug delivery. Nanocarriers based on such materials could improve the payload's pharmacokinetics and achieve the desired pharmacological response at the target tissue. Despite the development of rationally designed drug nanocarriers, only a handful of such formulations have been successfully translated into the clinic. Read More

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http://dx.doi.org/10.1016/j.addr.2019.01.002DOI Listing
January 2019
1 Read
15.038 Impact Factor

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications.

Adv Drug Deliv Rev 2019 Jan 10. Epub 2019 Jan 10.

Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany; Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands; Department of Targeted Therapeutics, University of Twente, Enschede, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2019.01.005DOI Listing
January 2019
1 Read

Nanotechnology in peripheral nerve repair and reconstruction.

Adv Drug Deliv Rev 2019 Jan 11. Epub 2019 Jan 11.

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, AvePark, 4805-017 Barco, Guimarães, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2019.01.006DOI Listing
January 2019
1 Read

Zebrafish as a preclinical in vivo screening model for nanomedicines.

Adv Drug Deliv Rev 2019 Jan 4. Epub 2019 Jan 4.

Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address:

The interactions of nanomedicines with biological environments is heavily influenced by their physicochemical properties. Formulation design and optimization are therefore key steps towards successful nanomedicine development. Unfortunately, detailed assessment of nanomedicine formulations, at a macromolecular level, in rodents is severely limited by the restricted imaging possibilities within these animals. Read More

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http://dx.doi.org/10.1016/j.addr.2019.01.001DOI Listing
January 2019
1 Read

Matrix-assisted Cell Transplantation for Tissue Vascularization.

Adv Drug Deliv Rev 2018 Dec 31. Epub 2018 Dec 31.

Department of Bioengineering, University of California, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA. Electronic address:

Cell therapy offers much promise for the treatment of ischemic diseases by augmenting tissue vasculogenesis. Matrix-assisted cell transplantation (MACT) has been proposed as a solution to enhance cell survival and integration with host tissue following transplantation. By designing semi synthetic matrices (sECM) with the correct physical and biochemical signals, encapsulated cells are directed towards a more angiogenic phenotype. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.016DOI Listing
December 2018
1 Read

Advanced drug delivery systems and artificial skin grafts for skin wound healing.

Adv Drug Deliv Rev 2018 Dec 31. Epub 2018 Dec 31.

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA; Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require painstakingly long-term treatment with an immense financial burden to healthcare systems worldwide. However, clinical management of chronic wounds remains unsatisfactory in many cases. Various strategies including growth factor and gene delivery as well as cell therapy have been used to enhance the healing of non-healing wounds. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.014DOI Listing
December 2018
5 Reads
15.038 Impact Factor

Articular fibrocartilage - Why does hyaline cartilage fail to repair?

Adv Drug Deliv Rev 2018 Dec 31. Epub 2018 Dec 31.

AO Research Institute Davos, 7270 Davos Platz, Switzerland. Electronic address:

Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded versus naïve cells may explain one of the biggest discrepancies in mesenchymal stromal/stem cell (MSC) based cartilage regeneration. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.015DOI Listing
December 2018
9 Reads

Phage-based vaccines.

Adv Drug Deliv Rev 2018 Dec 27. Epub 2018 Dec 27.

Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, China. Electronic address:

Bacteriophages, or more colloquially as phages, are viruses that possess the ability to infect and replicate with bacterial cells. They are assembled from two major types of biomolecules, the nucleic acids and the proteins, with the latter forming a capsid and the former being encapsulated. In the eukaryotic hosts, phages are inert particulate antigens and cannot trigger pathogenesis. Read More

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December 2018
8 Reads

Recent advances in nanotherapeutic strategies for spinal cord injury repair.

Adv Drug Deliv Rev 2018 Dec 22. Epub 2018 Dec 22.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. Electronic address:

Spinal cord injury (SCI) is a devastating and complicated condition with no cure available. The initial mechanical trauma is followed by a secondary injury characterized by inflammatory cell infiltration and inhibitory glial scar formation. Due to the limitations posed by the blood-spinal cord barrier, systemic delivery of therapeutics is challenging. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.011DOI Listing
December 2018
1 Read

Influencing neuroplasticity in stroke treatment with advanced biomaterials-based approaches.

Adv Drug Deliv Rev 2018 Dec 21. Epub 2018 Dec 21.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada. Electronic address:

Since the early 1990s, we have known that the adult brain is not static and has the capacity to repair itself. The delivery of various therapeutic factors and cells have resulted in some exciting pre-clinical and clinical outcomes in stroke models by targeting post-injury plasticity to enhance recovery. Developing a deeper understanding of the pathways that modulate plasticity will enable us to optimize delivery strategies for therapeutics and achieve more robust effects. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.012DOI Listing
December 2018
1 Read

Extracellular vesicles for personalized medicine: The input of physically triggered production, loading and theranostic properties.

Adv Drug Deliv Rev 2018 Dec 13. Epub 2018 Dec 13.

Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS, Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, Paris 75205, France. Electronic address:

Emerging advances in extracellular vesicle (EV) research brings along new promises for tailoring clinical treatments in order to meet specific disease features of each patient in a personalized medicine concept. EVs may act as regenerative effectors conveying endogenous therapeutic factors from parent cells or constitute a bio-camouflaged delivery system for exogenous therapeutic agents. Physical stimulation may be an important tool in the field of EVs for personalized therapy by powering EV production, loading and therapeutic properties. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.009DOI Listing
December 2018
16 Reads
15.038 Impact Factor

Photo-triggered polymer nanomedicines: From molecular mechanisms to therapeutic applications.

Adv Drug Deliv Rev 2018 Dec 13. Epub 2018 Dec 13.

Laboratoire de Chimie des Polymères Organiques, Université de Bordeaux, Bordeaux INP, UMR CNRS 5629, 16 Avenue Pey-Berland, Pessac 33607, France. Electronic address:

The use of nanotechnology to improve treatment efficacy and reduce side effects is central to nanomedicine. In this context, stimuli-responsive drug delivery systems (DDS) such as chemical/physical gels or nanoparticles such as polymersomes, micelles or nanogels are particularly promising and are the focus of this review. Several stimuli have been considered but light as an exogenous trigger presents many advantages that are pertinent for clinical applications such as high spatial and temporal control and low cost. Read More

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December 2018
15 Reads

Design strategies for shape-controlled magnetic iron oxide nanoparticles.

Adv Drug Deliv Rev 2018 Dec 13. Epub 2018 Dec 13.

Dept. Energía, Medio Ambiente y Salud, Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, E-28049 Madrid, Spain. Electronic address:

Ferrimagnetic iron oxide nanoparticles (magnetite or maghemite) have been the subject of an intense research, not only for fundamental research but also for their potentiality in a widespread number of practical applications. Most of these studies were focused on nanoparticles with spherical morphology but recently there is an emerging interest on anisometric nanoparticles. This review is focused on the synthesis routes for the production of uniform anisometric magnetite/maghemite nanoparticles with different morphologies like cubes, rods, disks, flowers and many others, such as hollow spheres, worms, stars or tetrapods. Read More

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December 2018
11 Reads

Superparamagnetic iron oxides as MPI tracers: A primer and review of early applications.

Authors:
Jeff W M Bulte

Adv Drug Deliv Rev 2018 Dec 13. Epub 2018 Dec 13.

Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Department of Chemical & Biomolecular Engineering, Department of Biomedical Engineering, Department of Oncology, The Johns Hopkins University School of Medicine, 217 Traylor Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA. Electronic address:

Magnetic particle imaging (MPI) has recently emerged as a non-invasive, whole body imaging technique that detects superparamagnetic iron oxide (SPIO) nanoparticles similar as those used in magnetic resonance imaging (MRI). Based on tracer "hot spot" detection instead of providing contrast on MRI scans, MPI has already proven to be truly quantitative. Without the presence of endogenous background signal, MPI can also be used in certain tissues where the endogenous MRI signal is too low to provide contrast. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.007DOI Listing
December 2018
1 Read

Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond.

Adv Drug Deliv Rev 2018 Dec 13. Epub 2018 Dec 13.

MedImmune, Gaithersburg, MD 20878, United States. Electronic address:

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. Non-hematopoietic cells expressing CD40 can also engage CD40L and trigger a pro-inflammatory response. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.005DOI Listing
December 2018
1 Read

Therapeutic medications against diabetes: What we have and what we expect.

Adv Drug Deliv Rev 2018 Dec 5. Epub 2018 Dec 5.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, People's Republic of China. Electronic address:

Diabetes has become one of the largest global health and economic burdens, with its increased prevalence and high complication ratio. Stable and satisfactory blood glucose control are vital to reduce diabetes-related complications. Therefore, continuous attempts have been made in antidiabetic drugs, treatment routes, and traditional Chinese medicine to achieve better disease control. Read More

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http://dx.doi.org/10.1016/j.addr.2018.11.008DOI Listing
December 2018
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Aggregation-induced emission (AIE) fluorophores as imaging tools to trace the biological fate of nano-based drug delivery systems.

Adv Drug Deliv Rev 2018 Dec 6. Epub 2018 Dec 6.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology of China, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

The vigorous development of nanotechnology has been accompanied by an equally strong interest and research efforts in nano-based drug delivery systems (NDDSs). However, only a few NDDSs have been translated into clinic thus far. One of the important hurdles is the lack of tools to comprehensively and directly trace the biological fate of NDDSs. Read More

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December 2018
3 Reads

Molecular imaging of diabetes and diabetic complications: Beyond pancreatic β-cell targeting.

Adv Drug Deliv Rev 2018 Dec 5. Epub 2018 Dec 5.

Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address:

Diabetes is a chronic non-communicable disease affecting over 400 million people worldwide. Diabetic patients are at a high risk of various complications, such as cardiovascular, renal, and other diseases. The pathogenesis of diabetes (both type 1 and type 2 diabetes) is associated with a functional impairment of pancreatic β-cells. Read More

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December 2018
1 Read

Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems.

Adv Drug Deliv Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemical Engineering, Institute of Biomedical Engineering, and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan, ROC. Electronic address:

The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.001DOI Listing
December 2018
5 Reads

Engineering lymphocytes with RNAi.

Adv Drug Deliv Rev 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Precision NanoMedicine, School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Lymphocytes are the gatekeepers of the body's immune system and are involved in pathogenesis if their surveillance is stalled by inhibitory molecules or when they act as mediators for viral entry. Engineering lymphocytes in order to restore their functions is an unmet need in immunological disorders, cancer and in lymphotropic viral infections. Recently, the FDA approved several therapeutic antibodies for blocking inhibitory signals on T cells. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.002DOI Listing
December 2018
2 Reads

Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges.

Adv Drug Deliv Rev 2018 Dec 4. Epub 2018 Dec 4.

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Mawson Lakes Campus, Mawson Lakes 5095, Australia. Electronic address:

Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the promising biopharmaceutical benefits of liquid lipid formulations has not translated into widespread commercial success, due to their susceptibility to long term storage and in vivo precipitation issues. One strategy that has emerged to overcome such limitations, is to combine the solubilisation and dissolution enhancing properties of lipids with the stabilising effects of solid carrier materials. Read More

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http://dx.doi.org/10.1016/j.addr.2018.11.006DOI Listing
December 2018
2 Reads

Advances in transdermal insulin delivery.

Adv Drug Deliv Rev 2018 Dec 8. Epub 2018 Dec 8.

Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; California NanoSystems Institute, Jonsson Comprehensive Cancer Center, Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA 90095, USA. Electronic address:

Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for diabetes management in recent years. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.006DOI Listing
December 2018
1 Read

Advances in immunotherapy of type I diabetes.

Adv Drug Deliv Rev 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Type 1 diabetes mellitus (T1DM) is an autoimmune disease affecting 3 million individuals in the U.S. The pathogenesis of T1DM is driven by immune-mediated destruction of pancreatic β cells, the source of glucose regulator insulin. Read More

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http://dx.doi.org/10.1016/j.addr.2018.12.003DOI Listing
December 2018
1 Read

ADDR Editor's Collection 2018.

Adv Drug Deliv Rev 2018 Nov - Dec;136-137

Departments of Pharmaceutics and Pharmaceutical Chemistry, and of Bioengineering, Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, 5205 SMBB, 36 S. Wasatch Dr., Salt Lake City, UT 84112-5001, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2018.11.005DOI Listing
December 2018
2 Reads

Editorial: Drug delivery in older people - unique challenges and important opportunities.

Adv Drug Deliv Rev 2018 Oct;135:1-2

Sydney Medical School, Faculty of Medicine and Health University of Sydney, NSW, Australia; Charles Perkins Centre, University of Sydney, New South Wales, Australia; Centre for Education and Research on Aging and Anzac Research Institute, Concord Hospital and University of Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/j.addr.2018.11.002DOI Listing
October 2018
5 Reads

Bacteriophage-based biomaterials for tissue regeneration.

Adv Drug Deliv Rev 2018 Nov 16. Epub 2018 Nov 16.

Department of Chemistry & Biochemistry, Stephenson Life Science Research Center, Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, 101 Stephenson Parkway, Norman, OK 73019, United States; School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China. Electronic address:

Bacteriophage, also called phage, is a human-safe bacteria-specific virus. It is a monodisperse biological nanostructure made of proteins (forming the outside surface) and nucleic acids (encased in the protein capsid). Among different types of phages, filamentous phages have received great attention in tissue regeneration research due to their unique nanofiber-like morphology. Read More

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http://dx.doi.org/10.1016/j.addr.2018.11.004DOI Listing
November 2018
11 Reads
15.040 Impact Factor

Drug supersaturation during formulation digestion, including real-time analytical approaches.

Authors:
Martin Kuentz

Adv Drug Deliv Rev 2018 Nov 13. Epub 2018 Nov 13.

Dept. of Pharmaceutical Technology, Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstr. 30, Muttenz 4132, Switzerland. Electronic address:

Self-emulsifying and other lipid-based drug delivery systems have drawn considerable interest from pharmaceutical scientists for managing oral delivery of poorly water-soluble compounds. Following administration, self-emulsifying systems exhibit complex aqueous dispersion and digestion in the gastro-intestinal tract. These processes generally result in drug supersaturation, which leads to enhanced absorption or the high drug concentrations may cause precipitation with erratic and variable oral bioavailability. Read More

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http://dx.doi.org/10.1016/j.addr.2018.11.003DOI Listing
November 2018
2 Reads

Aptamers in Therapeutics and Drug Delivery.

Adv Drug Deliv Rev 2018 Sep;134:1-2

Department of Biochemistry and Physiology, Faculty of Medicine, The University of Jordan, Amman, Jordan; Qatar Genome Project, Qatar Foundation, Doha, Qatar.

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http://dx.doi.org/10.1016/j.addr.2018.11.001DOI Listing
September 2018
85 Reads

Neurotheranostics as personalized medicines.

Adv Drug Deliv Rev 2018 Oct 26. Epub 2018 Oct 26.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

The discipline of neurotheranostics was forged to improve diagnostic and therapeutic clinical outcomes for neurological disorders. Research was facilitated, in largest measure, by the creation of pharmacologically effective multimodal pharmaceutical formulations. Deployment of neurotheranostic agents could revolutionize staging and improve nervous system disease therapeutic outcomes. Read More

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http://dx.doi.org/10.1016/j.addr.2018.10.011DOI Listing
October 2018
2 Reads

Drug delivery systems for programmed and on-demand release.

Adv Drug Deliv Rev 2018 Jul 6;132:104-138. Epub 2018 Jul 6.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. Electronic address:

With the advancement in medical science and understanding the importance of biodistribution and pharmacokinetics of therapeutic agents, modern drug delivery research strives to utilize novel materials and fabrication technologies for the preparation of robust drug delivery systems to combat acute and chronic diseases. Compared to traditional drug carriers, which could only control the release of the agents in a monotonic manner, the new drug carriers are able to provide a precise control over the release time and the quantity of drug introduced into the patient's body. To achieve this goal, scientists have introduced "programmed" and "on-demand" approaches. Read More

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http://dx.doi.org/10.1016/j.addr.2018.07.002DOI Listing
July 2018
2 Reads

Successful development of oral SEDDS: screening of excipients from the industrial point of view.

Adv Drug Deliv Rev 2018 Nov 7. Epub 2018 Nov 7.

ThioMatrix GmbH, Research Center Innsbruck, Trientlgasse 65, Innsbruck 6020, Austria. Electronic address:

Oral administration is the most accepted and favored route as various side effects such as fear, pain and risk of infections can be avoided resulting in a comparatively high patient compliance. However, from the industrial point of view the development of oral delivery systems is still challenging as various drugs are poorly soluble as well as slightly permeable leading to low bioavailability. As self-emulsifying drug delivery systems are able to incorporate both hydrophobic and hydrophilic drugs, these carrier systems have received more and more attention within the last years. Read More

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http://dx.doi.org/10.1016/j.addr.2018.10.014DOI Listing
November 2018
13 Reads

Approaches to physical stimulation of metallic nanoparticles for glioblastoma treatment.

Adv Drug Deliv Rev 2018 Nov 7. Epub 2018 Nov 7.

Université de Lorraine, CNRS, CRAN, F-54000 Nancy, France. Electronic address:

Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. Despite new knowledges on the genetic characteristics, conventional therapy for GBM, tumor resection followed by radiotherapy and chemotherapy using temozolomide is limited in efficacy due to high rate of recurrence. GBM is indeed one of the most complex and difficult cancer to treat mainly due to its highly invasive properties and the standard treatments are thus rarely curative. Read More

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http://dx.doi.org/10.1016/j.addr.2018.10.013DOI Listing
November 2018
9 Reads
15.040 Impact Factor

Electric field-responsive nanoparticles and electric fields: physical, chemical, biological mechanisms and therapeutic prospects.

Adv Drug Deliv Rev 2018 Nov 7. Epub 2018 Nov 7.

Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, Paul Sabatier, 205, Route de Narbonne, 31077, Toulouse, France. Electronic address:

Electric fields are among physical stimuli that have revolutionized therapy. Occurring endogenously or exogenously, the electric field can be used as a trigger for controlled drug release from electroresponsive drug delivery systems, can stimulate wound healing and cell proliferation, may enhance endocytosis or guide stem cell differentiation. Electric field pulses may be applied to induce cell fusion, can increase the penetration of therapeutic agents into cells, or can be applied as a standalone therapy to ablate tumors. Read More

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http://dx.doi.org/10.1016/j.addr.2018.10.017DOI Listing
November 2018
2 Reads

Recent insights in magnetic hyperthermia: From the "hot-spot" effect for local delivery to combined magneto-photo-thermia using magneto-plasmonic hybrids.

Adv Drug Deliv Rev 2018 Nov 7. Epub 2018 Nov 7.

Sorbonne Université, CNRS, PHysico-chimie des Electrolytes et Nanosystèmes InterfaciauX, PHENIX, F-75005 Paris, France. Electronic address:

Magnetic hyperthermia which exploits the heat generated by magnetic nanoparticles (MNPs) when exposed to an alternative magnetic field (AMF) is now in clinical trials for the treatment of cancers. However, this thermal therapy requires a high amount of MNPs in the tumor to be efficient. On the contrary the hot spot local effect refers to the use of specific temperature profile at the vicinity of nanoparticles for heating with minor to no long-range effect. Read More

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http://dx.doi.org/10.1016/j.addr.2018.10.016DOI Listing
November 2018
10 Reads

Imaging and therapeutic applications of persistent luminescence nanomaterials.

Adv Drug Deliv Rev 2018 Nov 7. Epub 2018 Nov 7.

Unité de Technologies Chimiques et Biologiques pour la Santé, CNRS UMR 8258, Inserm U 1022, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France.. Electronic address:

The development of probes for biomolecular imaging and diagnostics is a very active research area. Among the different imaging modalities, optics emerged since it is a noninvasive and cheap imaging technique allowing real time imaging. In vitro, this technique is very useful however in vivo, fluorescence suffers from low signal-to-noise ratio due to tissue autofluorescence under constant excitation. Read More

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http://dx.doi.org/10.1016/j.addr.2018.10.015DOI Listing
November 2018
4 Reads

Current and Emerging Inhaled Therapies of Repositioned Drugs.

Adv Drug Deliv Rev 2018 Aug;133:1-4

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http://dx.doi.org/10.1016/j.addr.2018.09.008DOI Listing
August 2018
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3D-Bioprinting and Micro-/Nano-Technology: Emerging Technologies in Biomedical Sciences.

Adv Drug Deliv Rev 2018 Jul;132:1-2

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585.

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http://dx.doi.org/10.1016/j.addr.2018.09.007DOI Listing
July 2018
2 Reads

Local delivery of macromolecules to treat diseases associated with the colon.

Adv Drug Deliv Rev 2018 Nov - Dec;136-137:2-27. Epub 2018 Oct 22.

UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

Current treatments for intestinal diseases including inflammatory bowel diseases, irritable bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage forms designed for systemic delivery. The intestinal permeability hurdle to achieve systemic delivery from oral formulations of macromolecules is challenging, but this drawback can be advantageous if an intestinal region is associated with the disease. There are some promising formulation approaches to release peptides, proteins, antibodies, antisense oligonucleotides, RNA, and probiotics in the colon to enable local delivery and efficacy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X183025
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http://dx.doi.org/10.1016/j.addr.2018.10.009DOI Listing
October 2018
15 Reads