534,880 results match your criteria Advanced Composites Letters[Journal]


Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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http://dx.doi.org/10.1055/s-0039-1678750DOI Listing
November 2018
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Arachnoid web of the spine: a systematic literature review.

J Neurosurg Spine 2019 Apr 19:1-10. Epub 2019 Apr 19.

2Department of Neurosurgery, Weill Cornell Brain and Spine Center, New York, New York.

OBJECTIVEAn arachnoid web of the spine (AWS) is a rare and oftentimes challenging lesion to diagnose, given its subtle radiographic findings. However, when left untreated, this lesion can have devastating effects on a patient's neurological function. To date, only limited case reports and series have been published on this topic. Read More

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http://dx.doi.org/10.3171/2019.1.SPINE181371DOI Listing

Current status of small molecule drug development for Ebola virus and other filoviruses.

Curr Opin Virol 2019 Apr 16;35:42-56. Epub 2019 Apr 16.

Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, United States. Electronic address:

The filovirus family includes some of the deadliest viruses known, including Ebola virus and Marburg virus. These viruses cause periodic outbreaks of severe disease that can be spread from person to person, making the filoviruses important public health threats. There remains a need for approved drugs that target all or most members of this virus family. Read More

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http://dx.doi.org/10.1016/j.coviro.2019.03.001DOI Listing

Design of porous titanium scaffold for complete mandibular reconstruction: The influence of pore architecture parameters.

Comput Biol Med 2019 Mar 12;108:31-41. Epub 2019 Mar 12.

Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, West Bengal, India. Electronic address:

Patients having a medical history of oral cancer, infectious diseases or trauma are often advised surgical intervention with customized complete mandibular constructs (CMC) made of Titanium (Ti) scaffolds. A numerical framework based on a homogenization technique was developed to investigate the influence of pore architecture parameters on homogenized orthotropic material properties of the scaffolds. A comparative 3D Finite Element (FE) analysis of six CMC models, having homogenized orthotropic material properties, under a mastication cycle, was undertaken to pre-clinically determine the optimal CMC for a patient. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193007
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.004DOI Listing
March 2019
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Synthesis and optimization of the trimesic acid modified polymeric carbon nitride for enhanced photocatalytic reduction of CO.

J Colloid Interface Sci 2019 Apr 13;548:197-205. Epub 2019 Apr 13.

School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address:

The conjugated co-monomer, trimesic acid (TMA) was integrated into the triazine framework of polymeric carbon nitride (PCN), synthesized through chemical condensation of urea. The TMA-modified carbon nitride samples obtained were named as CNU-TMA and it was utilized for the photocatalytic reduction of carbon dioxide (CO) under visible light illumination. The induction of such electron donor-acceptor co-monomer (TMA) dominates the intramolecular structure of PCN by acting as a nucleophilic substitution substrate to facilitate the electron density in the π-electron conjugated system of PCN and thus elevate its photocatalytic activity. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.04.037DOI Listing

Subjective unpleasantness of malodors induces a stress response.

Psychoneuroendocrinology 2019 Mar 22;106:206-215. Epub 2019 Mar 22.

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan; ERATO Touhara Chemosensory Signal Project, JST, The University of Tokyo, Tokyo, 113-8657, Japan; International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study, Tokyo, 113-0033 Japan. Electronic address:

Unpleasant odors impair our mood and may affect physical health, even when the odorants are not toxic. A possible cause for such negative effects is stress induced by odors; however, whether the unpleasantness itself elicited stress or not has not been clear. Thus, we examined whether unpleasantness of odors induced the stress responses of emotion, the hypothalamic-pituitary-adrenal (HPA) axis, and the sympathetic nervous system (SNS). Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.018DOI Listing

Association between sarcopenia and diabetes in community dwelling elderly in the Amazon region - Viver Mais Project.

Arch Gerontol Geriatr 2019 Mar 27;83:121-125. Epub 2019 Mar 27.

State University Of Pará, Brazil; Hospital Cynthia Charone, Brazil.

Background: Studies indicate the intrinsic relationship between sarcopenia and diabetes mellitus (DM) pathophysiological mechanisms. Changes in insulin and muscular metabolism are features of diabetic patients and can interact as sarcopenic accelerators. Conversely, sarcopenic patients feature lower glucose tolerance and higher serum insulin levels, predisposing them to DM. Read More

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http://dx.doi.org/10.1016/j.archger.2019.03.020DOI Listing

Stability and toxicity studies for duloxetine and econazole on Spirodela polyrhiza using chiral capillary electrophoresis.

J Hazard Mater 2019 Apr 5;374:203-210. Epub 2019 Apr 5.

Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares (Madrid), Spain; Instituto de Investigación Química Andrés M. del Río, Universidad de Alcalá, Ctra, Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares (Madrid), Spain. Electronic address:

Stability and toxicity studies for duloxetine and econazole were achieved using individual solutions and their mixtures. Stability of drugs racemates and enantiomers was investigated under abiotic and biotic conditions. Toxicity was evaluated for the first time on Spirodela polyrhiza. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.027DOI Listing

Heritability estimates of individual psychological distress symptoms from genetic variation.

J Affect Disord 2019 Apr 8;252:413-420. Epub 2019 Apr 8.

Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea. Electronic address:

Background: Psychological distress symptoms are associated with an increased risk of psychiatric disorders and medical illness. Although psychological distress is influenced by environmental factors, such as socioeconomic status, lifetime events, or interpersonal relationships, substantial interindividual variation also exists. However, heritability and genetic determinants of distress are poorly understood. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.011DOI Listing

Advanced methods to calculation of pressure drop during aeration in composting process.

Sci Total Environ 2019 Apr 11;674:19-25. Epub 2019 Apr 11.

West Pomeranian University of Technology Szczecin, Poland.

The objective of our research work was to develop a model that could be used to determine resistance of air flow through a bed of organic material processed in composting operation. The raw material used for testing was organic fraction below 80 mm separated from municipal waste. The range of process parameters values treated as independent variables was: for hydraulic load 8. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.155DOI Listing

Rationally introduce AIE into chemosensor: A novel and efficient way to achieving ultrasensitive multi-guest sensing.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 10;218:263-270. Epub 2019 Apr 10.

Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education of China; Research Center of Gansu Military and Civilian Integration Advanced Structural Materials; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, 730070, China.

Recently, ultrasensitive detection and multi-guest sensing have received extensive attention due to their high sensitivity and efficiency. Herein, we report a novel approach to achieve ultrasensitive detection of multi-analyte. This approach is concluded as "rationally introduce Aggregation-Induced Emission (AIE) into chemosensor". Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.014DOI Listing

Clinical vasospasm after an extended endoscopic assisted approach for recurrent pituitary adenoma. Illustrative case and systematic review of the literature.

World Neurosurg 2019 Apr 16. Epub 2019 Apr 16.

Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università; degli Studi di Napoli "Federico II", Naples, Italy.

Introduction: Cerebral vasospasm causing delayed cerebral ischemia after transsphenoidal surgery is a rare but life-threatening complication. Reports in the literature regarding extended endonasal endoscopic assisted (EEEA) approaches are scarce. Considering the progressive use of this technique during the last years, a better understanding of potential adverse effects after this procedure is needed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.046DOI Listing

Allogeneic stem cell transplantation for acute lymphoblastic leukemia in adolescents and young adults.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan.

Hematologic stem cell transplantation (HSCT) is the most potent consolidation therapy for high-risk acute lymphoblastic leukemia (ALL), but their outcomes and complications in adolescent and young adult (AYA) patients are still unclear. We compared outcomes after HSCT for ALL among children (1 to 9 years old, n = 607), adolescents (10 to 19 years old, n= 783) and young adults (20 to 29 years old, n = 603), based on nationwide registry data in Japan. The overall survival rate among AYA patients was worse than that of children; survival rate at 5 years among AYA patients was 64% (95% confidence intervals [CI], 60% to 68%). Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.014DOI Listing

Sustainable Agriculture: From Sweet Sorghum Planting, Ensiling to Ruminant Feeding.

Authors:
Qi Xie Zhihong Xu

Mol Plant 2019 Apr 16. Epub 2019 Apr 16.

School of Advanced Agricultural Sciences, Peking University, Beijing 100871, China. Electronic address:

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http://dx.doi.org/10.1016/j.molp.2019.04.001DOI Listing

Advanced Stage Non-Small Cell Lung Cancer: Advances in Thoracic Oncology 2018.

J Thorac Oncol 2019 Apr 16. Epub 2019 Apr 16.

Guangdong Lung Cancer Institute; Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences; Guangzhou; China.

In 2018 research in the field of advanced non-small cell lung cancers (NSCLC) led to an expanded reach and impact of immune-checkpoint inhibitors (ICIs) as part of frontline treatment strategy, regardless of histology subtype, while ICI use was extended to include stage III disease, shifting the prognosis of all these patients. This new standard first-line approach opens a gap in standard second-line treatment, and older combinations may again become standard care after progression on ICIs. The characterization of predictive biomarkers, patient selection, the definition of strategies with ICI combinations upon progression on ICIs, as well as prospective evaluation of the efficacy of ICIs in subpopulations (such as patients with poor performance status or brain metastases) represent upcoming challenges in advanced thoracic malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.03.022DOI Listing
April 2019
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Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

Pharmacol Res 2019 Apr 16. Epub 2019 Apr 16.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB) Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

In spite of billions of dollars expended on cancer research every year, the incidence rate and the mortality rate due to this widespread disease has increased drastically over the last few decades. Recent reports from the World Health Organization advocate that overall global cancer burden and deaths due to cancer are expected to double by the next decade. Synthetic drugs developed as chemotherapeutics have repeatedly shown adverse side effects and development of chemoresistance. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.004DOI Listing
April 2019
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Detection of cell-free, exosomal and whole blood mitochondrial DNA copy number in plasma or whole blood of patients with serous epithelial ovarian cancer.

J Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Department of Human Genetics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Ovarian tumor is one of the leading causes of cancer among women. Patients are diagnosed at an advanced stage, usually. There is a need for new specific and sensitive biomarkers. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.04.015DOI Listing

Redox homeostasis in a rodent model of circadian disruption: Effect of melatonin supplementation.

Gen Comp Endocrinol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry, University of Allahabad, Allahabad 211002, India. Electronic address:

Continuous light or dark photoperiods are the leading cause of disruption in the circadian rhythm of day-night cycle. The purpose of this study was to understand the cellular redox balance in a model of circadian disrupted rat model and determine the effect of melatonin supplementation. Young male Wistar rats were randomly divided into five groups (n = 4). Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.04.016DOI Listing

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection.

J Mol Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America. Electronic address:

Urinary tract infections (UTIs) are the most commonly reported infections in adult women and have high rates of recurrence, especially in postmenopausal women. Recurrent UTI (RUTI) greatly reduces quality of life, places a significant burden on the healthcare system, and contributes to antimicrobial resistance. Because treatment of RUTI by long-term antibiotic therapy is often ineffective or poorly tolerated in elderly women, new therapies must be developed. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.04.008DOI Listing

Mitigating Acetaminophen-Induced Hepatotoxicity by Using a Water-Alcohol Extract of Phellinus caryophylli (Agaricomycetes) in a Murine Model.

Int J Med Mushrooms 2019 ;21(4):367-380

Mar Athanasious College for Advanced Studies, Tiruvalla, Tiruvalla, Kerala, India; St.Gregorios Dental College & Research Centre, Kothamangalam, Kerala, India.

This study investigates the hepatoprotective effect of a water-alcohol extract of the medicinal mushroom Phellinus caryophylli (Racib.) G. Cunn. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030388DOI Listing
January 2019
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Gene Delivery Using Lipoplexes and Polyplexes: Principles, Limitations and Solutions.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):29-36

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Gene therapy has attracted considerable attention for the treatment of genetic and acquired diseases. Successful gene therapy occurs when the therapeutic genes penetrate targeted cells and become available to the intracellular active site. Currently, a promising approach in gene delivery is the use of nonviral gene delivery vectors that lack immunogenicity but have low toxicity and potential tissue specificity. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018025132DOI Listing
January 2019

Evaluation of Three Rapid Screening Tests for Detection of Hepatitis C Antibodies on Mass Scale.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):25-28

Department of Biotechnology, International Islamic University, Islamabad, Pakistan.

Hepatitis C virus (HCV) is a leading health problem across the globe. Only 20% of HCV positive individuals know their positive disease status. Effective HCV screening tests are required to screen both general and high-risk populations and identify the silent cases of HCV. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018025062DOI Listing
January 2019
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Advanced Epithelial Ovarian Cancer: Do More Options Mean Greater Benefits?

J Clin Oncol 2019 Apr 19:JCO1900500. Epub 2019 Apr 19.

1 Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

A healthy 51-year-old woman presented with increasing abdominal and pelvic pain. Computed tomography imaging of the abdomen and pelvis showed an 11.6-cm pelvic mass, retroperitoneal lymphadenopathy, right hydronephrosis, and mesenteric tumor deposits ( Fig 1A ). Read More

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http://dx.doi.org/10.1200/JCO.19.00500DOI Listing

Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.

J Clin Oncol 2019 Apr 19:JCO1801568. Epub 2019 Apr 19.

1 University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Purpose: To evaluate the impact of two different intraperitoneal (IP) chemotherapy regimens on progression-free survival (PFS) among women with newly diagnosed advanced ovarian carcinoma.

Methods: Eligible patients were randomly assigned to six cycles of IV paclitaxel 80 mg/m once per week with intravenous (IV) carboplatin area under the curve 6 (IV carboplatin) versus IV paclitaxel 80 mg/m once per week with IP carboplatin area under the curve 6 (IP carboplatin) versus once every 3 weeks IV paclitaxel 135 mg/m over 3 hours day 1, IP cisplatin 75 mg/m day 2, and IP paclitaxel 60 mg/m day 8 (IP cisplatin). All participants received bevacizumab 15 mg/kg IV every 3 weeks in cycles 2 to 22. Read More

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http://dx.doi.org/10.1200/JCO.18.01568DOI Listing

Investigating the effect of local warming on vein diameter in the antecubital area in adults aged 20-40 years.

Br J Nurs 2019 Apr;28(8):S20-S26

Faculty Member and Anaesthesiology Practitioner, Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: peripheral intravenous cannulation is the most prevalent invasive procedure performed on patients admitted to hospital. The procedure is not always easy to undertake and can lead to problems for the patient and nurse. Alongside various procedures, local warming is one technique that could be used to increase the diameter of superficial veins. Read More

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http://dx.doi.org/10.12968/bjon.2019.28.8.S20DOI Listing

International scoping exercise into expertise in children's orthopaedic nursing and educational pathways.

Authors:
Julia Judd

Br J Nurs 2019 Apr;28(8):518-522

Advanced Nurse Practitioner, Southampton University Hospital.

Maintaining competence and keeping skills and knowledge in children's orthopaedic nursing alive are problematic in both the UK and Australia. The dearth of dedicated postgraduate courses for this specialty has resulted in an array of unregulated in-house training, nurses' individual educational needs not being met and potential for children with an orthopaedic problem being put at risk of not receiving optimal care. This paper reports on a travel scholarship used to compare and contrast the UK with Australia, which supported an international scoping exercise to identify nurses' beliefs regarding expertise in children's orthopaedic nursing and explore provision for maintaining pertinent knowledge and skills. Read More

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http://dx.doi.org/10.12968/bjon.2019.28.8.518DOI Listing

Let's standardise practice.

Authors:
Andrew Barton

Br J Nurs 2019 Apr;28(8):S3

Advanced Nurse Practitioner, Vascular Access and IV Therapy, Frimley Health NHS Foundation Trust, and Chair, NIVAS.

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http://dx.doi.org/10.12968/bjon.2019.28.8.S3DOI Listing
April 2019
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Fast Formation and Encapsulation of All-inorganic Lead Halide Perovskites at Room Temperature in Metal-Organic Frameworks.

J Phys Chem Lett 2019 Apr 19. Epub 2019 Apr 19.

Improving the stability and tuning the optical properties of semiconducting perovskites are vital for their applications in advanced optoelectronic devices. We present a facile synthetic method for hybrid composites of perovskites and metal-organic frameworks (MOFs). A simple two-step solution-based method without organic surfactants was employed to make all-inorganic halide perovskites (CsPbX; X = Cl, Br, I, or mixed halide compositions) form directly in the pores of MIL-101 MOF. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b00510DOI Listing

Rapid Construction of Fused Heteropolycyclic Aromatics via Palladium-Catalyzed Domino Arylations of Imidazopyridine Derivatives.

Org Lett 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering , East China University of Science & Technology , 130 Meilong Road , Shanghai 200237 , China.

By using diaryliodonium salts, a novel approach of a palladium-catalyzed cascade of diarylation/intramolecular dehydrogenative coupling reaction has been developed in the synthesis of phenanthro-imidazopyridine fused heteropolycycles. The method can tolerate various substrates, and the target products were rapidly constructed in one pot. Furthermore, studies of the detailed reaction mechanism provide an insight into the C-H functionalization of 2-aryl-imidazopyridine derivatives and the C-C bond formations in the presence of palladium catalyst. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00761DOI Listing

Developing a new intelligent system for the diagnosis of oral medicine with case-based reasoning approach.

Oral Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Oral and Maxillofacial Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Since the clinical manifestations of many oral diseases can be quite similar despite the wide variety in etiology and pathology, the differential diagnosis of oral diseases is a complex and challenging process. Intelligent system for differential diagnosis of oral medicine using the artificial intelligence (AI) capabilities, helps specialists in achieving differential diagnosis in a wide range of oral diseases.

Materials And Methods: First, the essential data elements to design and develop an intelligent system were identified in a cross-sectional descriptive study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13108
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http://dx.doi.org/10.1111/odi.13108DOI Listing
April 2019
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Multi-subtype classification model for non-small cell lung cancer based on radiomics: SLS model.

Med Phys 2019 Apr 19. Epub 2019 Apr 19.

Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China.

Purpose: Histological subtypes of non-small cell lung cancer (NSCLC) are crucial for systematic treatment decisions. However, the current studies which used non-invasive radiomic methods to classify NSCLC histology subtypes mainly focused on two main subtypes: squamous cell carcinoma (SCC) and adenocarcinoma (ADC), while multi-subtype classifications that included the other two subtypes of NSCLC: large cell carcinoma (LCC) and not otherwise specified (NOS), were very few in the previous studies. The aim of this work is to establish a multi-subtype classification model for the four main subtypes of NSCLC and improve the classification performance and generalization ability compared with previous studies. Read More

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http://dx.doi.org/10.1002/mp.13551DOI Listing

Longitudinal Muscle and Myocellular Changes in Community-Dwelling Men Over Two Decades of Successful Aging-The ULSAM Cohort Revisited.

J Gerontol A Biol Sci Med Sci 2019 Apr 19. Epub 2019 Apr 19.

Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.

Participants of the population-based Uppsala longitudinal study of adult men (ULSAM) cohort reaching more than 88 years of age (survivors, S) were investigated at age 70, 82, and 88-90 and compared at 70 years with non-survivors (NS) not reaching 82 years. Body composition, muscle mass and muscle histology were remarkably stable over 18 years of advanced aging in S. Analysis of genes involved in muscle remodeling showed that S had higher mRNA levels of myogenic differentiation factors (Myogenin, MyoD), embryonic myosin (eMyHC), enzymes involved in regulated breakdown of myofibrillar proteins (Smad2, Trim32, MuRF1,) and NCAM compared with healthy adult men (n = 8). Read More

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http://dx.doi.org/10.1093/gerona/glz068DOI Listing

Factors Associated With Use of Sipuleucel-T to Treat Patients With Advanced Prostate Cancer.

JAMA Netw Open 2019 Apr 5;2(4):e192589. Epub 2019 Apr 5.

Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor.

Importance: Sipuleucel-T is an immunotherapy that has been approved for use in patients with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). However, sipuleucel-T may not be available to some patients because of logistics, cost, and practice structure.

Objective: To identify factors associated with the adoption of sipuleucel-T across the United States. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2589DOI Listing
April 2019
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In Situ Ligand Transformation for Two-Step Spin Crossover in Fe[M(CN)] (M = Mo, Nb) Cyanido-Bridged Frameworks.

Inorg Chem 2019 Apr 19. Epub 2019 Apr 19.

Department of Chemistry, School of Science , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-0033 , Japan.

We report a unique synthetic route toward the multistep spin crossover (SCO) effect induced by utilizing the partial ligand transformation during the crystallization process, which leads to the incorporation of three different Fe complexes into a single coordination framework. The 3-acetoxypyridine (3-OAcpy) molecules were introduced to the self-assembled Fe-[M(CN)] (M = Mo, Nb) system in the aqueous solution which results in the partial hydrolysis of the ligand into 3-hydroxypyridine (3-OHpy). It gives two novel isostructural three-dimensional {Fe(3-OAcpy)(3-OHpy)[M(CN)]}· nHO (M = Mo, n = 0, FeMo; M = Nb, n = 1, FeNb) coordination frameworks. Read More

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http://pubs.acs.org/doi/10.1021/acs.inorgchem.9b00361
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http://dx.doi.org/10.1021/acs.inorgchem.9b00361DOI Listing
April 2019
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Maximizing Property Tuning of Phosphorus Corrole Photocatalysts through a Trifluoromethylation Approach.

Inorg Chem 2019 Apr 19. Epub 2019 Apr 19.

Schulich Faculty of Chemistry , Technion-Israel Institute of Technology , Haifa 32000 , Israel.

An eight-member series of CF-substituted difluorophosphorus corroles was prepared for establishing a structure-activity profile of these high-potential photosensitizers. It consisted of preparing all four possible isomers of the monosubstituted corrole and complexes with 2-, 3-, 4-, and 5-CF groups on the macrocycle's periphery. The synthetic pathway to these CF-substituted derivatives, beginning with (tpfc)PF, involves two different initial routes: (i) direct electrophilic CF incorporation using FSOCFCOMe and copper iodide, or (ii) bromination to achieve the 2,3,8,17,18-pentabrominated compound using excess bromine in methanol. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00436DOI Listing

Coupling a Low Loading of IrP2, PtP2 or Pd3P with Heteroatom-Doped Nanocarbon for Overall Water Splitting Cells and Zinc-Air Batteries.

ACS Appl Mater Interfaces 2019 Apr 19. Epub 2019 Apr 19.

Noble metal-based catalysts are currently the most advanced electrocatalysts for many applications, such as for energy conversion and for chemical industry. Due to the high cost and scarcity of noble metals, reducing the usage is a practical way to achieve scalable applications. Herein, for the first time, three novel electrocatalysts composed of noble-metal phosphide (IrP2, Pd3P or PtP2) nanoparticles with N, P co-doped nanocarbon were synthesized by the pyrolysis of mixtures of IrCl4, PdCl2 or PtCl4 with phytic acid under an ammonia atmosphere. Read More

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http://dx.doi.org/10.1021/acsami.8b21155DOI Listing

ESRRG promoter hypermethylation as a diagnostic and prognostic biomarker in laryngeal squamous cell carcinoma.

J Clin Lab Anal 2019 Apr 19:e22899. Epub 2019 Apr 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital of Ningbo University, Ningbo, China.

Background: Estrogen-related receptor gamma (ESRRG) has been identified as a tumor suppressor gene in several cancers. We aimed to evaluate ESRRG promoter methylation in laryngeal squamous cell carcinoma (LSCC) and its relative clinical value in LSCC.

Methods: Bisulfite pyrosequencing assays were performed on 91 pairs of tumor and paracancer tissues from LSCC patients in China. Read More

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http://dx.doi.org/10.1002/jcla.22899DOI Listing

Long noncoding RNA DSCAM-AS1 is associated with poor clinical prognosis and contributes to melanoma development by sponging miR-136.

Authors:
Y-L Huang Q Xu X Wang

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2888-2897

Department of Dermatology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China.

Objective: Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are playing critical roles in tumorigenesis. The present study aimed to investigate the expression pattern and effects of lncRNA DSCAM-AS1 (DSCAM-AS1) that was a newly discovered lncRNA in melanoma.

Patients And Methods: Real-time quantitative PCR (polymerase chain reaction) was performed to determine the expression of DSCAM-AS1 in melanoma tissues and cell lines. Read More

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http://www.europeanreview.org/article/17567
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http://dx.doi.org/10.26355/eurrev_201904_17567DOI Listing
April 2019
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Overexpression of miR-770 indicates a favorable prognosis and suppresses tumorigenesis by modulating PI3K-AKT pathway in glioma.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2870-2879

Department of Neurosurgery, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Objective: Previous studies showed that miR-770 expression was deregulated in many tumors. However, the effect of miR-770 function on glioma remains as a mystery. The present study aimed to explore its expression, cellular function and clinic features in glioma. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17565DOI Listing

A model of pre-pubertal broiler breeder estradiol-17β levels predicts advanced sexual maturation for birds with high body weight or short juvenile day-length exposure.

Poult Sci 2019 Apr 19. Epub 2019 Apr 19.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.

As broiler breeders face increased reproductive challenges specifically related to overfeeding, a clear understanding of the physiological effects of BW and rearing photoperiod on reproductive development is needed. The objective was to use mathematical models to compare plasma estradiol-17β (E2) concentration to characterize the effect of BW and rearing photoperiod on E2 levels. A 2 × 3 factorial arrangement of treatments was used. Read More

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http://dx.doi.org/10.3382/ps/pez224DOI Listing

Cost-Effectiveness Analysis of Integrated Care in Management of Advanced Chronic Obstructive Pulmonary Disease (COPD).

Med Sci Monit 2019 Apr 19;25:2879-2885. Epub 2019 Apr 19.

Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland.

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a common disease that occurs all over the world. Models of care, initially accessed from the clinical point of view, must also be evaluated in terms of their economic effectiveness, as health care systems are limited. The Integrated Care Model (ICM) is a procedure dedicated to patients suffering from advanced COPD that offers home-oriented support from a multidisciplinary team. Read More

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https://www.medscimonit.com/abstract/index/idArt/913358
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http://dx.doi.org/10.12659/MSM.913358DOI Listing
April 2019
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Correlation Analysis Between Stride Characteristics and Racing Ability of 2-year-old Yili Horses in Track Conditions.

J Equine Vet Sci 2019 Apr 30;75:19-24. Epub 2018 Dec 30.

College of Animal Science, Xinjiang Agricultural University, Urumqi, China. Electronic address:

In this study, we aimed to explore correlations among stride characteristics, time records, and bonus amounts to identify relevant indices for evaluating racing abilities of 2-year-old Yili horses. In total, 41 and 26 Yili horses were enrolled in the 1600 and 3600 m races, respectively. This experiment was performed by measuring their stride characteristics using a high-speed video and collecting time records during the competition and the bonus amounts. Read More

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http://dx.doi.org/10.1016/j.jevs.2018.12.022DOI Listing

APPLICATION OF ACTIVATED CARBON FROM BANANA STEM WASTE FOR REMOVAL OF HEAVY METAL IONS IN GREYWATER USING A BOX-BEHNKEN DESIGN APPROACH.

Environ Technol 2019 Apr 19:1-39. Epub 2019 Apr 19.

c Department of Chemical Engineering, Faculty of Engineering , Universiti Putra Malaysia , 43400 UPM Serdang , Selangor Darul Ehsan , Malaysia.

There is limited information on the optimal processes to remove heavy metals in greywater. A Response Surface Methodology (RSM) via the Box-Behnken Design (BBD) approach was applied in this study to investigate and optimise the process variables of activation time (1.5 - 2. Read More

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http://dx.doi.org/10.1080/09593330.2019.1609590DOI Listing

Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio.

Clin Mol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Cancer Center, University of Hawaii, Honolulu, HI, USA.

Background/aims: Inflammation-based scores, such as the neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis in hepatocellular carcinoma (HCC); but variable cut-off values and potential lack of specificity have limited the utility of NLR. This study evaluates NLR in a large cohort of HCC patients.

Methods: We retrospectively reviewed 789 HCC cases (1993-2017) for demographics, tumor characteristics, treatment, and survival. Read More

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http://dx.doi.org/10.3350/cmh.2019.0004DOI Listing
April 2019
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Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study.

J Korean Med Sci 2019 Apr 22;34(15):e117. Epub 2019 Apr 22.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Removal of uremic toxins such as indoxyl sulfate by AST-120 is known to improve renal function and delay the initiation of dialysis in patients with advanced chronic kidney disease. However, it is unclear whether the addition of AST-120 to conventional treatments is effective in delaying the progression of renal dysfunction in patients with diabetic nephropathy.

Methods: A total of 100 patients with type 2 diabetes and renal dysfunction (serum creatinine levels ranging from 1. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e117DOI Listing

Effect of S-1 on survival outcomes in 838 patients with advanced pancreatic cancer: A 7-year multicenter observational cohort study in Taiwan.

Cancer Med 2019 Apr 18. Epub 2019 Apr 18.

Division of Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Objective: Studies have rarely explored the efficacy of S-1 in treating advanced pancreatic cancer outside Japan. This study compared the survival outcomes of patients with advanced pancreatic cancer treated with S-1 with the survival outcomes of those without S-1 treatment before and after S-1 reimbursement was introduced in Taiwan in June of 2014.

Method: We retrospectively analyzed 838 patients with locally advanced or metastatic pancreatic cancer who underwent palliative chemotherapy from 2010 to 2016 at 4 institutes in Taiwan. Read More

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http://dx.doi.org/10.1002/cam4.2094DOI Listing

Intelligent TAT-coupled anti-HER2 immunoliposomes knock downed MDR1 to produce chemosensitize phenotype of multidrug resistant carcinoma.

J Cell Physiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Gene therapy using biocompatible cationic liposomes is amongst promising approaches that decreases death from cancers. Here an invasive multidrug resistant cell model has been developed by lentiviral transfection. In parallel phospholipids have been covalently conjugated to TAT, MMP2, and Herceptin. Read More

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http://dx.doi.org/10.1002/jcp.28683DOI Listing

Minimally invasive versus open distal pancreatectomy for pancreatic neuroendocrine tumors: An analysis from the U.S. neuroendocrine tumor study group.

J Surg Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio.

Background: To determine short- and long-term oncologic outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) for the treatment of pancreatic neuroendocrine tumor (pNET).

Methods: The data of the patients who underwent curative MIDP or ODP for pNET between 2000 and 2016 were collected from a multi-institutional database. Propensity score matching (PSM) was used to generate 1:1 matched patients with MIDP and ODP. Read More

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http://dx.doi.org/10.1002/jso.25481DOI Listing
April 2019
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Modifiable risk factors for advanced versus early breast cancer in the French E3N cohort.

Int J Cancer 2019 Apr 19. Epub 2019 Apr 19.

Inserm U1018, Center for Research in Epidemiology and Population Health (CESP), Gustave Roussy, Villejuif, France.

Advanced breast cancer (BC) are is associated with heavier treatments and poorer prognosis than early BC. Despite mammographic screening, advanced BC incidence remains stable. Little is known about risk factors differentially associated with advanced BC. Read More

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http://dx.doi.org/10.1002/ijc.32354DOI Listing
April 2019
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Circulating free DNA concentration as a marker of disease recurrence and metastatic potential in lung cancer.

Clin Transl Med 2019 Apr 18;8(1):14. Epub 2019 Apr 18.

Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Plasma circulating cell-free (cf) DNA is regarded as a source of tumor DNA. Based on availability of blood tissue for the purposes of early detection of cancer and patients' follow-up, several studies have evaluated concentration of cf DNA in cancer patients in association with tumor features. In the present study, we assessed concentration of cf DNA in lung cancer patients with two commercial kits (MN and QIAGEN) to find whether it can be used as a prognostic biomarker. Read More

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https://clintransmed.springeropen.com/articles/10.1186/s4016
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http://dx.doi.org/10.1186/s40169-019-0229-6DOI Listing
April 2019
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