603,546 results match your criteria Advanced Composites Letters[Journal]


The impact of microalbuminuria on overactive bladders: Results from a community-based four-year longitudinal study in Japan.

Neurourol Urodyn 2020 May 27. Epub 2020 May 27.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Aims: To investigate the longitudinal association of microalbuminuria with overactive bladder (OAB).

Methods: This longitudinal study investigated 561 participants of the Iwaki Health Promotion Project in both 2015 and 2019 in Japan. Microalbuminuria and OAB symptoms were assessed using the urine albuminuria creatinine ratio (ACR) and the overactive bladder symptom score (OABSS), respectively. Read More

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http://dx.doi.org/10.1002/nau.24405DOI Listing

Surgical Resection is Justifiable for Oral T4b Squamous Cell Cancers With Masticator Space Invasion.

Laryngoscope 2020 May 27. Epub 2020 May 27.

Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia, U.S.A.

Objectives: To examine survival endpoints in patients with tumor (T)4b oral cavity squamous cell carcinoma (OCSCC) with pathologically proven masticator space invasion treated with primary surgery followed by adjuvant therapy.

Study Design: Retrospective review at an academic cancer center.

Methods: Twenty-five patients with T4b OCSCC with pathologic masticator space invasion were treated with primary surgery from May 2012 to December 2016. Read More

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http://dx.doi.org/10.1002/lary.28725DOI Listing

Theoretical investigation of antiferromagnetic skyrmions in a triangular monolayer.

J Phys Condens Matter 2020 May 27. Epub 2020 May 27.

Peter Gruenberg Institut and Institute for Advanced Simulation, Forschungszentrum Juelich, D-52425 Juelich, Juelich, GERMANY.

The chiral spin textures of a two-dimensional (2D) triangular system, where both antiferromagnetic (AF) Heisenberg exchange and chiral Dzyaloshinsky-Moriya interactions co-exist, are investigated numerically with an optimized quantum Monte Carlo method based on mean-field theory. We find that: helical, skyrmionic and vortical AF crystals can be formed when an external magnetic field is applied perpendicular to the 2D monolayer; the sizes of these skyrmions and vortices change abruptly at several critical points of the external magnetic field; each of these AF crystals can be decomposed into three periodical ferromagnetic sublattices. The quantum ingredient implemented into the theoeretical framework helps to track the existence of AF skyrmion lattices down to low temperatures. Read More

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http://dx.doi.org/10.1088/1361-648X/ab96efDOI Listing

o-C240: a new sp3-dominated allotrope of carbon.

J Phys Condens Matter 2020 May 27. Epub 2020 May 27.

Department of Physics and Engineering Physics, University of Saskatchewan, Saskatoon, Saskatchewan, CANADA.

We report a new allotrope of carbon predicted from first principles simulations. This allotrope is formed in a simulated conversion of two-dimensional polymeric Cprecursor subjected to uniaxial compression at high temperature. The structure is made up of 240 carbon atoms in an orthorhombic unit cell (termed as-C) having a mixed/hybridization with the ratio of about 1:5. Read More

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http://dx.doi.org/10.1088/1361-648X/ab96f1DOI Listing

The Cyclic Value-Context Reinforcement Model of Problematic Internet Use: Empirical Validation Using a Thematic Analysis of Children's Counseling Data.

J Med Internet Res 2020 May 14. Epub 2020 May 14.

Graduate School of Convergence Science and Technology, Seoul National University, 1 Gwanakro, Seoul, KR.

Background: Research on problematic Internet use has focused on devising diagnostic criteria or describing the factors that influence Internet overuse. However, a paradigm shift is necessary in studying the phenomenon of increased Internet use not just from a pathological point of view, but also from a developmental point of view that considers children's behavior of adapting to a technology-oriented society.

Objective: In this paper, we propose the "Cyclic Value-Context Reinforcement Model" (CVCRM) to understand problematic Internet use behavior. Read More

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http://dx.doi.org/10.2196/17996DOI Listing

New prediction tool-LIST-with improved prediction accuracy for 30-day readmission rates in patients with head and neck cancer after major cancer surgery.

Oral Oncol 2020 May 24;108:104772. Epub 2020 May 24.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Department of Otolaryngology, Head and Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan; Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan. Electronic address:

We hope to establish a new readmission prediction score for patients with head and neck cancer (HNC) after major cancer surgery. A retrospective cohort study was conducted from the clinical and cancer registry data at Kaohsiung Veterans General Hospital. We included the data of patients with newly diagnosed HNC who underwent surgical treatment between Nov 2010 and Dec 2017. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104772DOI Listing

Cardiovascular mortality and morbidity following radical radiotherapy for lung cancer: Is cardiovascular death under-reported?

Lung Cancer 2020 May 13;146:1-5. Epub 2020 May 13.

Leeds Cancer Centre, Beckett Street, Leeds, UK. Electronic address:

Background: Lung cancer is the most common malignancy worldwide. Radical radiotherapy is an essential treatment in the management of early and locally advanced lung cancer. Cardiac events are known to occur following radical radiotherapy for lung cancer. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.05.004DOI Listing

Circulating tumor DNA analysis of EGFR-mutant non-small cell lung cancer patients receiving osimertinib following previous tyrosine kinase inhibitor treatment.

Lung Cancer 2020 May 11;145:173-180. Epub 2020 May 11.

Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands. Electronic address:

Objectives: Circulating tumor (ct)DNA analysis is rapidly gaining acceptance as a diagnostic tool to guide clinical management of advanced non-small cell lung cancer (NSCLC). Clinically-actionable EGFR mutations can be detected in ctDNA before or after first-line EGFR-Tyrosine Kinase Inhibitor (TKI) treatment, but data are limited for patients with a complex treatment history. This study aimed to explore the feasibility of ctDNA testing in a clinical setting of NSCLC patients receiving osimertinib as a second or third line EGFR-TKI. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.04.039DOI Listing

Ophthalmological assessment of crizotinib in advanced non-small-cell lung cancer.

Lung Cancer 2020 Apr 28;145:167-172. Epub 2020 Apr 28.

Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA, USA.

Objectives: During crizotinib clinical evaluation, visual disturbances, generally of grade 1 severity, were frequently reported adverse events (AE). Consequently, ophthalmologic assessments were included in a patient subgroup enrolled in PROFILE 1001 (NCT00585195), a phase 1, open-label, single-arm trial of crizotinib in patients with advanced non-small-cell lung cancer and are reported here.

Materials And Methods: At least 30 patients were required to undergo ophthalmologic assessments, including: best-corrected visual acuity (BCVA), refractive error, pupil size, slit-lamp anterior segment biomicroscopy, intraocular inflammation, intraocular pressure, retinal fundoscopic exams, fundus photography, ocular characteristics, and optical coherence tomography (OCT). Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.04.010DOI Listing

Evaluation of Somatostatin and CXCR4 Receptor Expression in a Large Set of Prostate Cancer Samples Using Tissue Microarrays and Well-Characterized Monoclonal Antibodies.

Transl Oncol 2020 May 24;13(9):100801. Epub 2020 May 24.

Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany. Electronic address:

Background: Prostate cancer (PCa) is the most common type of cancer among men in Western countries. Despite numerous therapeutic options, few treatments are available for patients with end-stage disease. In the present study, different somatostatin receptors (SSTs) and the chemokine receptor CXCR4 were evaluated for their suitability as novel therapeutic targets in PCa. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100801DOI Listing

Caregiving burden and sleep quality amongst family caregivers of Chinese male patients with advanced cancer: A cross-sectional study.

Eur J Oncol Nurs 2020 May 15;46:101774. Epub 2020 May 15.

The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Purpose: To examine the level of caregiving burden and sleep quality as well as their interrelationship amongst family caregivers of Chinese male patients with advanced cancer.

Method: A cross-sectional study was conducted in Hong Kong. The Caregiver Reaction Assessment (CRA) and the Pittsburgh Sleep Quality Index (PSQI) were used to measure caregiving burden and sleep quality of the family caregivers. Read More

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http://dx.doi.org/10.1016/j.ejon.2020.101774DOI Listing

Comparison of the biological characteristics of umbilical cord mesenchymal stem cells derived from the human heterosexual twins.

Differentiation 2020 May 18;114:1-12. Epub 2020 May 18.

Stem Cell Research Center, Henan Key Laboratory of Stem Cell Differentiation and Modification Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China; People's Hospital of Henan University, Zhengzhou, Henan, 450003, China. Electronic address:

Mesenchymal stromal/stem cells (MSCs) are attracting more and more attention due to their tissue regenerative properties and immunomodulatory functions. MSCs may be the most acceptable, safe, and effective source for allogeneic cell therapy, and have been used in medical treatment. However, the similarities and differences between umbilical cord-derived MSCs (UC-MSCs) of heterosexual twins remain poorly understood. Read More

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http://dx.doi.org/10.1016/j.diff.2020.05.005DOI Listing

Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease.

Redox Biol 2020 May 18;34:101546. Epub 2020 May 18.

Department of Neurology, University Clinic Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. Electronic address:

Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities, however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident, that advanced glycation end products (AGEs) trigger the accumulation of such modified proteins, which eventually contributes to pathological aspect of NDDs. Increased levels of AGEs are found in amyloid plaques in AD brains and in both advanced and early PD (incidental Lewy body disease). Read More

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http://dx.doi.org/10.1016/j.redox.2020.101546DOI Listing

Muscle strength is related to mental and physical quality of life in the oldest old.

Arch Gerontol Geriatr 2020 May 15;89:104109. Epub 2020 May 15.

Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore di Roma, Rome, Italy.

Purpose Of The Study: Quality of life represents the principal outcome of health interventions for the oldest old. However, little is known about the determinants of quality of life in this population stratum. We evaluated the association between health-related quality of life (HRQoL) and handgrip strength in a cohort of 331 participants aged 90+ with a living in the Mugello area (Tuscany, Italy). Read More

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http://dx.doi.org/10.1016/j.archger.2020.104109DOI Listing

Specific and effective detection of anammox bacteria using PCR primers targeting the 16S rRNA gene and functional genes.

Sci Total Environ 2020 May 15;734:139387. Epub 2020 May 15.

School of Food and Biotechnology, Guangdong Industry Polytechnic, Guangzhou, Guangdong 510300, People's Republic of China; Environmental Engineering, Guangdong Technion Israel Institute of Technology, 241 Daxue Road, Shantou, Guangdong 515063, People's Republic of China. Electronic address:

Anaerobic ammonium-oxidizing (anammox) bacteria play an important role in the nitrogen cycle by coupling ammonium and nitrite to produce dinitrogen gas (N). Polymerase chain reaction (PCR) is a fast, simple, and sensitive method that is widely used to assess the diversity, abundance, and activity of the slow-growing bacteria. In this review, we summarize and evaluate the wide variety of PCR primers targeting the 16S rRNA gene and functional genes (hzo, nir, and hzs) of anammox bacteria for their effectiveness and efficiencies in detecting this group of bacteria in different sample types. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139387DOI Listing

Luminescent anticancer Ru(II)-arenebipyridine and phenanthroline complexes: Synthesis, characterization, DFT studies, biological interactions and cellular imaging application.

J Inorg Biochem 2020 May 16;208:111099. Epub 2020 May 16.

Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamilnadu, India. Electronic address:

A series of ruthenium(II)-arene complexes of several bipyridine and phenanthroline derivatives have been synthesized by employing a green and efficient protocol involving water as a solvent under sonication. The structures of all the complexes were elucidated by the spectroscopic analysis. The geometry of the chlorido and PTA (1,3,5-Triaza-7-phosphaadamantane) complexes were further confirmed by DFT and single crystal XRD. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111099DOI Listing

Precise Mapping of Single Neurons by Calibrated 3D Reconstruction of Brain Slices Reveals Topographic Projection in Mouse Visual Cortex.

Cell Rep 2020 May;31(8):107682

Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea; Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea. Electronic address:

Recent breakthroughs in neuroanatomical tracing methods have helped unravel complicated neural connectivity in whole-brain tissue at single-cell resolution. However, in most cases, analysis of brain images remains dependent on highly subjective and sample-specific manual processing, preventing precise comparison across sample animals. In the present study, we introduce AMaSiNe, software for automated mapping of single neurons in the standard mouse brain atlas with annotated regions. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107682DOI Listing

Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.

Gut Microbes 2020 May 27:1-24. Epub 2020 May 27.

Biochemistry Research Centre, Central India Institute of Medical Sciences , Nagpur, India.

Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal diseases, particularly , in rural-agricultural and urban populations in Central India, where there is widespread unregulated antibiotic use. We utilized shotgun metagenomics to comprehensively characterize the bacterial and viral fractions of the gut microbiome and their encoded functions in 105 participants. Read More

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http://dx.doi.org/10.1080/19490976.2020.1752605DOI Listing

Circularly Polarized Photo-Luminescence from Chiral Perovskite Thin Films at Room Temperature.

ACS Nano 2020 May 27. Epub 2020 May 27.

Hybrid organic-inorganic perovskites allow the synthesis of high-quality, nanostructured semiconducting films via easily accessible solution-based techniques. This has allowed tremendous development in optoelectronic applications, primarily solar cells and light-emitting diodes. Allowed by the ease of access to nanostructure, chirality has recently been introduced in semiconducting perovskites, as a promising way to obtain advanced control of charge and spin and for developing circularly polarized light sources. Read More

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http://dx.doi.org/10.1021/acsnano.0c03628DOI Listing

Progress on Lithium Dendrite Suppression Strategies from the Interior to Exterior by Hierarchical Structure Designs.

Small 2020 May 27:e2000699. Epub 2020 May 27.

Shenzhen Geim Graphene, Center Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, P. R. China.

Lithium (Li) metal is promising for high energy density batteries due to its low electrochemical potential (-3.04 V) and high specific capacity (3860 mAh g ). However, the safety issues impede the commercialization of Li anode batteries. Read More

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http://dx.doi.org/10.1002/smll.202000699DOI Listing

Multisite cell- and neural-dynamics-resolving deep brain imaging in freely moving mice with implanted reconnectable fiber bundles.

J Biophotonics 2020 May 27. Epub 2020 May 27.

Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia.

We demonstrate a reconnectable implantable ultraslim fiber-optic microendoscope that integrates a branching fiber bundle (BFB) with gradient-index fiber lenses, enabling a simultaneous fluorescence imaging of individual cells in distinctly separate brain regions, including brain structures as distant as the neocortex and hippocampus. We show that fluorescence images of individual calcium-indicator-expressing neurons in the brain of freely moving transgenic mice can be recorded, via the implanted BFB probe, in parallel with time- and cell-resolved traces of calcium signaling, thus enabling correlated circuit-dynamics studies at -multiple sites within the brain of freely moving animals. This article is protected by copyright. Read More

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http://dx.doi.org/10.1002/jbio.202000081DOI Listing

α-triazolylboronic acids: a promising scaffold for effective inhibitors of KPCs.

ChemMedChem 2020 May 27. Epub 2020 May 27.

Case Western Reserve University, Department of Medicine, Pharmacology, Biochemistry and Molecular Biology and Microbiology, UNITED STATES.

Boronic Acids are known reversible covalent inhibitors of serine β-lactamases. The selectivity and high potency of specific boronates bearing an amide side chain mimicking the β-lactam's amide side chain have been advanced in several studies. Herein, we describe a new class of boronic acids where the amide group is replaced by a bioisostere triazole. Read More

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http://dx.doi.org/10.1002/cmdc.202000126DOI Listing

Comparative physiological and proteomic analysis deciphering tolerance and homeostatic signaling pathways in Chrysanthemum under drought stress.

Physiol Plant 2020 May 27. Epub 2020 May 27.

Horticulture and Molecular Physiology Lab, School of Agricultural Innovations and Advanced Learning, Vellore Institute of Technology, Vellore, -632014, Tamil-Nadu, India.

Drought is increasing prevalently, mostly due to global warming, and harmful effects associated with drought stress include a reduction in the developmental phases of the plant life cycle. Drought stress affects vital metabolic processes in plants such as transpiration, photosynthesis, and respiration. The other physiological and cellular processes like protein denaturation and aggregation are also affected by drought. Read More

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http://dx.doi.org/10.1111/ppl.13142DOI Listing

Hahahahaha, Duuuuude, Yeeessss!: A two-parameter characterization of stretchable words and the dynamics of mistypings and misspellings.

PLoS One 2020 27;15(5):e0232938. Epub 2020 May 27.

Department of Mathematics and Statistics, University of Vermont, Burlington, VT, United States of America.

Stretched words like 'heellllp' or 'heyyyyy' are a regular feature of spoken language, often used to emphasize or exaggerate the underlying meaning of the root word. While stretched words are rarely found in formal written language and dictionaries, they are prevalent within social media. In this paper, we examine the frequency distributions of 'stretchable words' found in roughly 100 billion tweets authored over an 8 year period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232938PLOS

Using Cutaneous Receptor Vibration to Uncover the Effect of Transcranial Magnetic Stimulation (TMS) on Motor Cortical Excitability.

Med Sci Monit 2020 May 27;26:e923166. Epub 2020 May 27.

Department of Neuroscience, Laboratory for Human and Experimental Neurophysiology (LAHEN), University of Split School of Medicine, Split, Croatia.

BACKGROUND Little is known about how vibrational stimuli applied to hand digits affect motor cortical excitability. The present transcranial magnetic stimulation (TMS) study investigated motor evoked potentials (MEPs) in the upper extremity muscle following high-frequency vibratory digit stimulation. MATERIAL AND METHODS High-frequency vibration was applied to the upper extremity digit II utilizing a miniature electromagnetic solenoid-type stimulator-tactor in 11 healthy study participants. Read More

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http://dx.doi.org/10.12659/MSM.923166DOI Listing

Breast Augmentation in the Transfemale Patient: Comprehensive Principles for Planning and Obtaining Ideal Results.

Plast Reconstr Surg 2020 Jun;145(6):1343-1353

Baltimore and Timonium, Md. From the Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine; and the Center for Advanced Plastic Surgery.

Background: A growing number of transgender women present to plastic surgeons seeking breast augmentation. Despite some advocating their technical similarity, the authors have found substantially different planning and techniques are needed to obtain aesthetic results in transgender patients versus cosmetic breast augmentation. The authors sought to develop an approach for operative planning and technique to elucidate these differences and obtain consistent results. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006819DOI Listing

The Value and Importance of Certification.

Authors:
Renee J Hinojosa

Plast Surg Nurs 2020 Apr/Jun;40(2):67

Renee J. Hinojosa, MSN, APRN, ACNS-BC, CPSN, CANS, is Director of Medical Aesthetics at the Age Management Institute in Reno, NV. She has been active in the field of plastic surgical nursing for more than 27 years. She also provides medical aesthetic treatments for the practice of Dr. Phillip Dahan at Advanced Aesthetic Plastic Surgery. In addition, she is a national trainer for AAI (Aesthetic Advancements Incorporated).

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http://dx.doi.org/10.1097/PSN.0000000000000308DOI Listing

Topoisomerase II-binding protein 1 promotes the progression of prostate cancer via ATR-CHK1 signaling pathway.

Aging (Albany NY) 2020 May 27;12. Epub 2020 May 27.

Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

DNA damage response (DDR) plays an important role in the progression of cancers, including prostate cancer (PCa). Topoisomerase II-binding protein 1 (TopBP1) is an essential promotor of ATR-mediated DDR. Herein, we investigated the association between TopBP1 and PCa and determined its effect on the progression of PCa. Read More

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http://dx.doi.org/10.18632/aging.103260DOI Listing

Computed tomographic and ultrasonographic diagnosis with successful excision of a lipoma in a shusui koi .

J Am Vet Med Assoc 2020 Jun;256(12):1379-1385

Case Description: A client-owned 12-year-old 10.3-kg (22.7-lb) female shusui koi () was evaluated because of an ulcerated mass on the left body wall, hyporexia, and decreased activity. Read More

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http://dx.doi.org/10.2460/javma.256.12.1379DOI Listing

Cytoplasmic streaming drifts the polarity cue and enables posteriorization of the zygote at the side opposite of sperm entry.

Mol Biol Cell 2020 May 27:mbcE20010058. Epub 2020 May 27.

Cell Architecture Laboratory, Structural Biology Center, National Institute of Genetics, Mishima 411-8540, Japan.

Cell polarization is required to define body axes during development. The position of spatial cues for polarization is critical to direct the body axes. In zygotes, the sperm-derived pronucleus/centrosome complex (SPCC) serves as the spatial cue to specify the anterior-posterior axis. Read More

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http://dx.doi.org/10.1091/mbc.E20-01-0058DOI Listing

Study on the relationship between reduced scattering coefficient and Young's modulus of tumors in microwave ablation.

Minim Invasive Ther Allied Technol 2020 May 27:1-9. Epub 2020 May 27.

Lauterberg Imaging Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

In the clinical treatment of tumors using microwave ablation (MWA), although temperature can be used as an important reference index for evaluating the curative effect of ablation, it cannot fully reflect the biological activity status of tumor tissue during thermal ablation. Finding multi-parameter comprehensive evaluation factors to achieve real-time evaluation of therapeutic effects has become the key for precise ablation. More and more scholars use the reduced scattering coefficient ([Formula: see text]) and Young's modulus (E) to evaluate the treatment outcomes of MWA. Read More

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http://dx.doi.org/10.1080/13645706.2020.1742742DOI Listing

Switchable Full-Color Reflective Photonic Ellipsoidal Particles.

J Am Chem Soc 2020 May 27. Epub 2020 May 27.

Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, United States.

Full-color reflective photonic ellipsoidal polymer particles, capable of a dynamic color change, are created from dendronized brush block copolymers (-BBCPs) self-assembled by solvent-evaporation from an emulsion. Surfactants composed of dendritic monomer units allow for the precise modulation of the interfacial properties of -BBCP particles to transition in shape from spheres to striped ellipsoids. Strong steric repulsions between wedge-type monomers promote rapid self-assembly of polymers into large domains (i. Read More

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http://dx.doi.org/10.1021/jacs.0c02398DOI Listing

Physical and biological properties of blend-electrospun polycaprolactone/chitosan-based wound dressings loaded with N-decyl-N, N-dimethyl-1-decanaminium chloride: An in vitro and in vivo study.

J Biomed Mater Res B Appl Biomater 2020 May 27. Epub 2020 May 27.

Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.

Dual-pump electrospinning of antibacterial N-decyl-N, N-dimethyl-1-decanaminium-chloride (DDAC)-loaded polycaprolactone (PCL) nanofibers, and chitosan (CS)/polyethylene-oxide (PEO)-based wound dressings with hydrophilic and hydrophobic properties to eliminate and absorb pathogenic bacteria from wound surface besides antibacterial action and to support wound healing and accelerate its process. Physicochemical properties of the prepared nanofibrous mat as well as antibacterial, cytotoxicity, and cell compatibility were studied. The full-thickness excisional wound healing properties up to 3 weeks using hematoxylin and eosin and Masson-trichrome staining were investigated. Read More

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http://dx.doi.org/10.1002/jbm.b.34636DOI Listing

Initiation of Intrathecal Drug Delivery Dramatically Reduces Systemic Opioid Use in Patients With Advanced Cancer.

Neuromodulation 2020 May 27. Epub 2020 May 27.

Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA.

Objectives: Pain is common in cancer, affecting more than 70% of patients with advanced disease. Intrathecal drug delivery systems (IDDS) are a well-established treatment for patients with refractory cancer pain, improving pain control and reducing associated side effects. To date, details of systemic opioid use before and after IDDS implant have not been reported. Read More

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http://dx.doi.org/10.1111/ner.13175DOI Listing

Targeting immune checkpoints: Building better therapeutic puzzle in pancreatic cancer combination therapy.

Eur J Cancer Care (Engl) 2020 May 27:e13268. Epub 2020 May 27.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Pancreatic cancer is related to a very weak diagnosis; the close parallel between disease incidence and mortality rates from pancreatic cancer reflects the fatal nature of this disease. Although early detection procedures are growing, they are not applicable yet for pancreatic cancer. The majority of cancer patients suffer from advanced disease, in which surgery has no potential effect. Read More

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http://dx.doi.org/10.1111/ecc.13268DOI Listing

CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.

J Cell Mol Med 2020 May 27. Epub 2020 May 27.

Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.

Targeting the androgen receptor (AR) signalling pathway remains the main therapeutic option for advanced prostate cancer. However, resistance to AR-targeting inhibitors represents a great challenge, highlighting the need for new therapies. Activation of the PI3K/AKT pathway and increased expression of histone deacetylases (HDACs) are common aberrations in prostate cancer, suggesting that inhibition of such targets may be a viable therapeutic strategy for this patient population. Read More

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http://dx.doi.org/10.1111/jcmm.15281DOI Listing

Risk of disease recurrence and survival in patients with multiple myeloma: A German study group analysis using a conditional survival approach with long-term follow-up of 815 patients.

Cancer 2020 May 27. Epub 2020 May 27.

Department of Medicine I, University of Freiburg Medical Center, Freiburg, Germany.

Background: Unlike the traditional method of overall survival prediction in patients with cancer, conditional survival predicts the survival of patients dynamically throughout the course of disease, identifying how a prognosis evolves over time.

Methods: The authors assessed 815 consecutive patients with multiple myeloma through the German Study Group on Multiple Myeloma (Deutsche Studiengruppe Multiples Myelom; DSMM) incentive. Over 10 variables, including patient-specific and multiple myeloma-specific parameters, were analyzed at the time of initial diagnosis and repeatedly during follow-up. Read More

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http://dx.doi.org/10.1002/cncr.32978DOI Listing

Validation of the 7-item Functional Assessment of Cancer Therapy-General (FACT-G7) as a short measure of quality of life in patients with advanced cancer.

Cancer 2020 May 27. Epub 2020 May 27.

Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Background: Assessing quality of life is essential for individuals with advanced cancer, but lengthy assessments can be burdensome. The authors investigated the psychometric characteristics of the FACT-G7, a 7-item quality-of-life measure derived from the Functional Assessment of Cancer Therapy-General (FACT-G) scale, in advanced cancer.

Methods: Data were obtained from outpatients with advanced cancer who were enrolled in a randomized controlled trial of early palliative care. Read More

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http://dx.doi.org/10.1002/cncr.32981DOI Listing

The enhanced liver fibrosis (ELF)-Index predicts hepatic fibrosis superior to FIB4 and APRI in HIV/HCV infected patients.

Clin Infect Dis 2020 May 27. Epub 2020 May 27.

University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Accurate non-invasive biomarkers of fibrotic progression are important for HCV management, but commonly used modalities may have decreased efficacy in HIV/HCV-coinfected persons. The enhanced liver fibrosis (ELF)-index is a highly sensitive non-invasive marker of hepatic fibrosis that has had limited assessment in the HIV/HCV population. We compared ELF-index performance to FIB4 and APRI at different stages of liver fibrosis as determined by liver histology, and validated the efficacy of the three non-invasive biomarkers in HIV/HCV-coinfected versus HCV-monoinfected. Read More

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http://dx.doi.org/10.1093/cid/ciaa646DOI Listing

Intelligent image-activated cell sorting 2.0.

Lab Chip 2020 May 27. Epub 2020 May 27.

Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan. and Japan Science and Technology Agency, Kawaguchi 332-0012, Japan and Department of Bioengineering, University of California, Los Angeles, California 90095, USA and Institute of Technological Sciences, Wuhan University, Hubei 430072, China.

The advent of intelligent image-activated cell sorting (iIACS) has enabled high-throughput intelligent image-based sorting of single live cells from heterogeneous populations. iIACS is an on-chip microfluidic technology that builds on a seamless integration of a high-throughput fluorescence microscope, cell focuser, cell sorter, and deep neural network on a hybrid software-hardware data management architecture, thereby providing the combined merits of optical microscopy, fluorescence-activated cell sorting (FACS), and deep learning. Here we report an iIACS machine that far surpasses the state-of-the-art iIACS machine in system performance in order to expand the range of applications and discoveries enabled by the technology. Read More

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http://dx.doi.org/10.1039/d0lc00080aDOI Listing

Epoxide and oxetane based liquid crystals for advanced functional materials.

Soft Matter 2020 May 27. Epub 2020 May 27.

Laboratory of Stimuli-responsive Functional Materials and Devices, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Groene Loper 5, 5612 AE Eindhoven, The Netherlands.

Liquid crystalline elastomers (LCEs) and liquid crystalline networks (LCNs) are classes of polymers very suitable for fabricating advanced functional materials. Two main pathways to obtain LCEs and LCNs have gained the most attention in the literature, namely the two-step crosslinking of LC side-chain polymers and the photoinitiated free-radical polymerisation of acrylate LC monomers. These liquid crystal polymers have demonstrated remarkable properties resulting from their anisotropic shapes, being used in soft robotics, responsive surfaces and as photonic materials. Read More

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http://dx.doi.org/10.1039/d0sm00489hDOI Listing

A highly efficient preconcentration route for rapid and sensitive detection of endotoxin based on an electrochemical biosensor.

Analyst 2020 May 27. Epub 2020 May 27.

Key Disciplines Lab of Novel Micro-Nano Devices and System Technology & Key Laboratory of Optoelectronic Technology and Systems (Ministry of Education), College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China. and International R & D center of Micro-nano Systems and New Materials Technology, Chongqing University, Shapingba, Chongqing 400044, China.

An impedimetric aptasensor for the detection of endotoxin in a microfluidic chip was proposed, in which the Apt/AuNPs/SPCE sensing surface was fabricated in a screen-printed electrode with good biological activity and stability. The quantitative detection of endotoxin was accomplished by electrochemical impedance spectroscopy (EIS) measurement before and after exposing to samples. The impedance biosensor offers an ultrasensitive and selective detection of endotoxin down to 500 pg mL-1 with a wide linear range from 500 pg mL-1 to 200 ng mL-1. Read More

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http://dx.doi.org/10.1039/d0an00315hDOI Listing

Rapid sub-micromolar amperometric enzyme biosensing with free substrate access but without nanomaterial signalling support: oxidase-based glucose detection as a proof-of-principle example.

Chem Commun (Camb) 2020 May 27. Epub 2020 May 27.

School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wang Chan Valley, Rayong 21210, Thailand.

High-sensitivity electrochemical glucose biosensing has so far been possible only through incorporation of nanomaterials into the glucose oxidase-(GOx) containing polymer layer on the detector surface. Here, as a conceptionally novel simplified option, pure gelatin thin films with covalently attached GOx were used to convert platinum (Pt) disk electrodes into rapidly responding amperometric glucose probes with a sub-micromolar limit of detection. The advanced enzymatic tools are easy to make and, as is crucial for a focus on waste minimization, green and sustainable, through restriction of sensor modification to readily available economical materials. Read More

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http://dx.doi.org/10.1039/d0cc01976cDOI Listing

Predicting the phase diagram of titanium dioxide with random search and pattern recognition.

Phys Chem Chem Phys 2020 May 27. Epub 2020 May 27.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. and TCM Group, Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue, Cambridge, CB3 0HE, UK and Trinity College, Trinity Street, Cambridge, CB2 1TQ, UK.

Predicting phase stabilities of crystal polymorphs is central to computational materials science and chemistry. Such predictions are challenging because they first require searching for potential energy minima and then performing arduous free-energy calculations to account for entropic effects at finite temperatures. Here, we develop a framework that facilitates such predictions by exploiting all the information obtained from random searches of crystal structures. Read More

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http://dx.doi.org/10.1039/d0cp02513eDOI Listing

Ecophysiology of nickel hyperaccumulating plants from South Africa - from ultramafic soil and mycorrhiza to plants and insects.

Metallomics 2020 May 27. Epub 2020 May 27.

Department of Botany and Zoology, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa. and AGH University of Science and Technology, Faculty of Physics & Applied Computer Science, Al. Mickiewicza 30, 30-059 Kraków, Poland.

An overview of 30 years of studies related to South African nickel hyperaccumulators is presented. Only five species have so far been identified as Ni hyperaccumulator plants among very rich and diversified South African flora. All of them occur on soils derived from ultramafic (serpentine) rocks and belong to the family Asteraceae: Berkheya coddii Roessler, Berkheya zeyheri subsp. Read More

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http://dx.doi.org/10.1039/c9mt00282kDOI Listing

Reliability, Feasibility, and Patient Acceptance of an Electronic Version of a Multidimensional Health Assessment Questionnaire for Routine Rheumatology Care: Validation and Patient Preference Study.

JMIR Form Res 2020 May 27;4(5):e15815. Epub 2020 May 27.

ZiteLab ApS, Copenhagen, Denmark.

Background: A multidimensional health assessment questionnaire (MDHAQ) that was developed primarily for routine rheumatology care has advanced clinical research concerning disease burden, disability, and mortality in rheumatic diseases. Routine Assessment of Patient Index Data 3 (RAPID3), an index within the MDHAQ, is the most widely used index to assess rheumatoid arthritis (RA) in clinical care in the United States, and it recognizes clinical status changes in all studied rheumatic diseases. MDHAQ physical function scores are far more significant in the prognosis of premature RA mortality than laboratory or imaging data. Read More

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http://dx.doi.org/10.2196/15815DOI Listing

Laparoscopic Partial Nephrectomy.

J Endourol 2020 May;34(S1):S17-S24

The Smith Institute for Urology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York, USA.

Renal cell carcinoma has historically been managed by radical nephrectomy, but as knowledge of the disease has advanced, nephron sparing surgery has become the norm in appropriately selected tumors. Laparoscopic partial nephrectomy (LPN) has been shown to have comparable oncologic outcomes and a shorter convalescence period compared to the traditional open partial nephrectomy. Dissemination of techniques has led to significantly increased use of minimally invasive nephron sparing surgery, and LPN remains a cost-effective and efficacious method for approaching small renal masses. Read More

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http://dx.doi.org/10.1089/end.2018.0307DOI Listing

Remote and Selective C(sp)-H Olefination for Sequential Regioselective Linkage of Phenanthrenes.

Org Lett 2020 May 27. Epub 2020 May 27.

Hubei Collaborative Innovation Center for Advanced Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.

Biphenylcarboxylic acid with two competing C(sp)-H sites was designed for site selective C(sp)-H functionalization by developing carboxylic acids assisted remote and selective olefination via 7-membered palladacycle. Mechanism investigation and DFT calculations reveal a kinetics-determined process, which could be utilized to explore a variety of remote site selectivity. The practicability of this method was highlighted by the precise construction of phenathrene under sequential site selectivity. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01208DOI Listing

Palladium-Catalyzed C-2 and C-3 Dual C-H Functionalization of Indoles: Synthesis of Fluorinated Isocryptolepine Analogues.

Org Lett 2020 May 27. Epub 2020 May 27.

Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, People's Republic of China.

Here we report a protocol to synthesize diversiform fluorinated isocryptolepine analogues with potential biological activities in one step via directed C-2 and C-3 dual C-H functionalization of indoles. We also attempted to take into account fluorinated imidoyl chlorides as a novel kind of synthons in the directed C-H functionalization reactions. As a result, a variety of fluorinated isocryptolepine analogues were obtained in up to 96% yield. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01159DOI Listing

Circulating activated lymphocyte subsets as potential blood biomarkers of cancer progression.

Cancer Med 2020 May 27. Epub 2020 May 27.

Department of Thoracic surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

The objective of this study was to predict the value of lymphocyte subsets in cancer progression. Peripheral blood was obtained from 327 untreated patients with cancer and 158 healthy volunteers. Levels of lymphocyte subsets were determined by flow cytometry. Read More

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http://dx.doi.org/10.1002/cam4.3150DOI Listing
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