72,516 results match your criteria Advance for nurse practitioners[Journal]
J Oncol Pract 2018 Dec;14(12):e775-e785
Memorial Sloan Kettering Cancer Center, New York, NY.
Background:: Prior work to integrate early palliative care in oncology has focused on patients with advanced cancer and primarily on palliative care consultation. We developed this outpatient clinic initiative for newly diagnosed patients at any stage, emphasizing primary (nonspecialist) palliative care by oncology teams, with enhanced access to palliative care specialists.
Methods:: We piloted the project in two medical oncology specialty clinics (for patients with myelodysplastic syndrome and GI cancer, respectively) to establish feasibility. Read More
J Oncol Pract 2018 Dec;14(12):e786-e793
Icahn School of Medicine at Mount Sinai, New York, NY; and The Everett Clinic, Providence Regional Medical Center, Everett, WA.
Purpose:: The Quality Oncology Practice Initiative (QOPI) is a quality measurement and improvement program designed to assess practice performance for various consensus-based and evidence-based measures. In this study, we evaluated differences in QOPI metrics met among patients with advanced solid cancer receiving routine oncologic care alone (routine care) compared with patients receiving integrated oncology and specialty-level palliative care (supportive care).
Methods:: We conducted a retrospective chart review of 100 randomly selected patients treated between June 2013 and June 2015 from our supportive care group and matched these patients to 100 routine care group patients on the basis of tumor type and initial oncology visit date. Read More
Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.
Department of Neonatology, Puerta de Hierro Majadahonda University Hospital, Madrid.
Aim: To evaluate the immediate clinical impact of donor human milk availability in a NICU about nutritional, clinical and biometric parameters.
Methods: This retrospective-cohort study included 28-32 weeks gestational age born at our hospital in a three-year period before and after the donor human milk implementation. Data about starting, advance and discharge enteral nutrition, clinical outcomes, hospital stay and biometrics, was collected. Read More
J Am Geriatr Soc 2018 Dec 10. Epub 2018 Dec 10.
Department of Health Policy, Vanderbilt University School of Medicine, Nashville, Tennessee.
Background/objectives: Relatively little is known regarding predictors of advance care planning (ACP) in former nurses. We aimed to evaluate potential predictors of ACP documentation and discussion.
Design: Cross-sectional study, 2012-2014. Read More
Angew Chem Int Ed Engl 2018 Dec 11. Epub 2018 Dec 11.
Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 West Yangqiao Road, CHINA.
K2TiF6:Mn4+ is a highly efficient narrow-band emission red phosphor with promising applications in white LEDs and wide-gamut displays. Nevertheless, the poor moisture-resistant property of this material hinders its further commercialization. Herein, we introduce a convenient reverse cation exchange strategy to construct a core-shell structured K2TiF6:Mn4+@K2TiF6 phosphor. Read More
Cogn Affect Behav Neurosci 2018 Dec 10. Epub 2018 Dec 10.
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.
Despite dopamine's significant role in models of value-based decision-making and findings demonstrating loss of dopamine function in aging, evidence of systematic changes in decision-making over the life span remains elusive. Previous studies attempting to resolve the neural basis of age-related alteration in decision-making have typically focused on physical age, which can be a poor proxy for age-related effects on neural systems. There is growing appreciation that aging has heterogeneous effects on distinct components of the dopamine system within subject in addition to substantial variability between subjects. Read More
Methods Mol Biol 2019 ;1905:175-185
Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.
Incorporation of bile drainage system into engineered liver tissue is an important issue to advance liver regenerative medicine. Our group reported that three-dimensional (3D) coculture of fetal liver cells (FLCs) and adult rat biliary epithelial cells (BECs) allows reconstruction of hepatic spheroids that possess bile ductular structures. In this chapter, we describe the detailed protocol to isolate FLCs and BECs and to generate the spheroids with bile drainage system using these two types of primary cells. Read More
Methods Mol Biol 2019 ;1877:233-246
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
The BCL-2 family proteins are key regulators of programmed cell death or apoptosis, and represent important targets for the development of anticancer drugs. Because their functions are intimately connected with intracellular membranes, it is important to perform structural and activity studies in precisely characterized samples that include phospholipids and capture the features of the native physiological environment as closely as possible. NMR studies and activity assays based on lipid bilayer nanodiscs are ideally suited for this purpose: they enable the conformations and interactions of these proteins to be probed at atomic resolution in their membrane-associated states. Read More
J Cardiovasc Transl Res 2018 Dec 7. Epub 2018 Dec 7.
Institute of Cardiovascular Sciences, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.
As the most populous country worldwide, China has ≈ 290 million patients with cardiovascular diseases (CVDs), representing the leading cause of death in Chinese population. The morbidity and mortality of CVDs are continuously rising. Here, we will first summarize the recent advance in the management of CVDs such as coronary arterial disease, arrhythmia, and heart failure in China. Read More
Brief Bioinform 2018 Dec 10. Epub 2018 Dec 10.
Department of Healthcare Policy and Research, Weill Cornell Medicine at Cornell University, New York, NY, USA.
Owning to the rapid development of computer technologies, an increasing number of relational data have been emerging in modern biomedical research. Many network-based learning methods have been proposed to perform analysis on such data, which provide people a deep understanding of topology and knowledge behind the biomedical networks and benefit a lot of applications for human healthcare. However, most network-based methods suffer from high computational and space cost. Read More
Ann Oncol 2018 Dec 10. Epub 2018 Dec 10.
Medical Oncology Department, Hospital Universitario 12 de Octubre and i + 12 Research Institute, Madrid, Spain.
Introduction: Approximately 30% of tumor biopsies from patients with advanced-stage lung adenocarcinomas yield insufficient tissue for successful molecular subtyping. We have analyzed the clinical utility of next-generation sequencing (NGS) of cell-free circulating tumor DNA (ctDNA) in patients with inadequate tumor samples for tissue genotyping.
Methods: We conducted the study in a multi-institutional prospective cohort of clinically unselected patients with advanced-stage lung adenocarcinomas with insufficient tissue for EGFR, ALK or ROS1 genotyping across 12 Spanish institutions (n = 93). Read More
Oper Neurosurg (Hagerstown) 2018 Dec 10. Epub 2018 Dec 10.
Department of Neurosurgery, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.
Background: Stent retrievers and thrombosuction catheters have become the cornerstones of acute stroke therapy. A large-lumen catheter facilitates the passage of different instruments and the application of greater suction force to clots. However, positioning a flexible thrombosuction or intermediate catheter within a tortuous artery is difficult and time-consuming. Read More
Fam Pract 2018 Dec 10. Epub 2018 Dec 10.
Department of Primary and Community Care, Radboud University Medical Centre, Nijmegen, The Netherlands.
Background: Advance care planning (ACP) is a crucial element of palliative care. It improves the quality of end-of-life care and reduces aggressive and needless life-prolonging medical interventions. However, little is known about its application in daily practice. Read More
Commun Biol 2018 4;1:212. Epub 2018 Dec 4.
2Institute of Earth Science, The Hebrew University of Jerusalem, Jerusalem, 91904 Israel.
Sea ice microbial communities produce large amounts of the sulfur metabolite dimethylsulfoniopropionate (DMSP), a precursor of the climate cooling gas dimethylsulfide. Despite their importance to the polar sulfur cycle, drivers and metabolic pathways of sea ice DMSP are uncertain. Here we report the first measurements of sea ice DMSP sulfur isotopic composition (S/S ratio, δS). Read More
Front Neuroanat 2018 26;12:100. Epub 2018 Nov 26.
Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, United States.
The claustrum is a narrow subcortical brain structure that resides between the striatum and insular cortex. The function of the claustrum is not fully described, and while our previous work supports a role for the claustrum in top-down cognitive control of action, other evidence suggests the claustrum may be involved in detecting salient changes in the external environment. The anterior cingulate cortex (ACC) and the anterior insular (aINS) are the two major participants in the salience network of human brain regions that activate in response to salient stimuli. Read More
Indian J Psychol Med 2018 Nov-Dec;40(6):589-590
Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Indian J Psychol Med 2018 Nov-Dec;40(6):588-589
Department of Psychiatry, K.LE Academy of Higher Education's, J.N Medical College, Belagavi, Karnataka, India.
Indian J Psychol Med 2018 Nov-Dec;40(6):587-588
Department of Psychiatry, Adesh Medical College and Hospital, Kurukshetra, Haryana, India.
JB JS Open Access 2018 Sep 24;3(3):e0004. Epub 2018 Jul 24.
Cleveland Clinic Florida, Weston, Florida.
Background: Overlapping surgery occurs when a surgeon performs 2 procedures in an overlapping time frame. This practice is commonplace in the setting of total joint arthroplasty and is intended to increase patient access to experienced surgeons, improve efficiency, and advance the surgical competence of surgeons and trainees. The practice of overlapping surgery has been questioned because of safety and ethical concerns. Read More
PeerJ 2018 30;6:e5980. Epub 2018 Nov 30.
Department of Nursing, University of Alicante, Alicante, Spain.
Background: Postnatal bonding constitutes a major process during the postpartum period, and there is evidence that bonding difficulties have negative consequences for parents' mental health and the child's development. However, the conceptualization of postnatal bonding presents inconsistencies, as well as problems in having instruments that encompasses the father figure. The objective was to adapt the maternal postnatal attachment scale (MPAS) and the paternal postnatal attachment scale (PPAS) to Spanish, to evaluate its validity and reliability and to analyze the construct dimensionality of both questionnaires from a gender perspective. Read More
Int J Nanomedicine 2018 14;13:7517-7531. Epub 2018 Nov 14.
Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China,
Background: The delivery of treatment agents to inner ear with drug delivery system (DDS) has been under investigation to overcome the limitations of the conventional therapeutic agents in curing or alleviating the cisplatin ototoxicity.
Methods: In the present study, a novel targeted dexamethasone (DEX)-loaded DDS, A666-DEX-NP, was constructed for prevention from cisplatin-induced hearing loss. A666-(CLEPRWGFGWWLH) peptides specifically bind to prestin, which is limited to the outer hair cells (OHCs). Read More
Ann Indian Acad Neurol 2018 Oct-Dec;21(4):239-241
Department of Palliative Medicine, Karunashraya, Bengaluru, Karnataka, India.
The recent supreme court of India judgment on autonomy makes it necessary for all practicing neurologists to appraise themselves of the changing legal framework for End-of-Life decision-making in India. A pathway has been prescribed for advance care planning and medical futility decision-making. This is an evolving landscape and in a diverse country may vary substantially by geography. Read More
Gac Med Mex 2018 ;154(6):732-736
Universidad Nacional Autónoma de México, Facultad de Veterinaria y Zootecnia. Ciudad de México, México.
There are decisions at the end of life that currently are relevant as humanistic values. Respect for human life and dignity are part of human rights. The National Academy of Medicine of Mexico declares its posture about end-of-life decisions that include treatment refusal, limitation of the therapeutic effort, advance directives and palliative sedation, among others, with the purpose to favor a peaceful death. Read More
Gac Med Mex 2018 ;154(Supp 2):S61-S66
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Puebla, México.
Introduction: Diarrhea is a serious public health problem in Mexico and other countries. An alternative widely used in the treatment of diarrhea is the use of medicinal herbs. Infusions of chamomile and star anise, which have anti-inflammatory and antimotility properties, could help alleviate gastrointestinal disorders. Read More
Curr Opin Obstet Gynecol 2018 Dec 10. Epub 2018 Dec 10.
Department of Radiation Oncology, University of California, Los Angeles, USA.
Purpose Of Review: Radiation has long been a primary treatment modality in locally advanced gynecologic carcinomas and a tool for palliation of metastatic disease. Here we review advances in imaging and radiation technologies and the corresponding clinical evolution of the role for radiation oncology in the treatment of gynecologic malignancies.
Recent Findings: Advances in MRI are impacting diagnosis, radiation target delineation, planning, treatment delivery, and response assessment. Read More
Curr Sports Med Rep 2018 Dec;17(12):480-488
Collaborating Centre of Sports Medicine, University of Brighton, Eastbourne, UNITED KINGDOM.
Running economy, known as the steady-state oxygen consumption at a given submaximal intensity, has been proposed as one of the key factors differentiating East African runners from other running communities around the world. Kenyan runners have dominated middle- and long-distance running events and this phenomenon has been attributed, in part at least, to their exceptional running economy. Despite such speculation, there are no data on running mechanics during real-life situations such as during training or competition. Read More
J Nurs Adm 2019 Jan;49(1):28-34
Author Affiliations: Director of Nursing Research, Neonatal Intensive Care Unit (Dr DeGrazia), Nurse Scientist, Orthopedic Center (Dr Difazio), Director of Nursing Research, Cardiovascular and Critical Care Patient Services (Dr Connor), Vice President, Cardiovascular and Critical Care Patient Services, and Associate Chief Nursing Officer (Dr Hickey), Boston Children's Hospital, Massachusetts; Assistant Professor (Drs DeGrazia and Hickey), Clinical Instructor (Drs Difazio and Connor), Pediatrics, Harvard Medical School, Boston, Massachusetts; Instructor (Dr Difazio), Fitchburg State University, Massachusetts.
The Nurse Executive Committee for Research and Inquiry (NECRI) was established to align clinical inquiry with nursing clinical operations to advance nursing science and improve patient care and outcomes for patients and their families. The authors describe the development, structure, and function of NECRI, outcomes to date, and infrastructure necessary to support a sustainable model. Read More
Ther Drug Monit 2018 Dec 10. Epub 2018 Dec 10.
Division of Renal Diseases and Hypertension, University of Colorado at Denver, Aurora, CO.
Blood urea nitrogen (BUN) and serum creatinine are imperfect markers of kidney function because they are influenced by many renal and non-renal factors independent of kidney function. A biomarker that is released directly into the blood or urine by the kidney in response to injury may be a better early marker of drug-induced kidney toxicity than BUN and serum creatinine. Urine albumin and urine protein, as well as urinary markers kidney injury molecule-1 (KIM-1), β2-microglobulin (B2M), cystatin C, clusterin, and trefoil factor-3 (TFF-3) have been accepted by the Food and Drug Administration (FDA) and European Medicines Agency as highly sensitive and specific urinary biomarkers to monitor drug-induced kidney injury in preclinical studies and on a case-by-case basis in clinical trials. Read More
Neural Regen Res 2019 Feb;14(2):193-196
CIBERNED (Center for Networked Biomedical Research on Neurodegenerative Diseases, Ministry of Economy and Competitiveness, Institute Carlos III), Madrid; Neurosciences Area, Institute Biodonostia; Department of Neurology, University Hospital Donostia, San Sebastián, Spain; Department of Neurosciences, University of the Basque Country, Universidad País Vasco-Euskal Herria Unibertsitatea, San Sebastián, Spain.
Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, while the vast majority of amyotrophic lateral sclerosis cases are considered to be sporadic, resulting from the interaction between genes and environmental factors in predisposed individuals. During the past few years, dozens of drugs have been postulated as promising strategies for the disease after showing some beneficial effects in preclinical cellular and murine models. Read More
J Bacteriol 2018 Dec 10. Epub 2018 Dec 10.
Microbial Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, 1111, Yata, Mishima, Shizuoka, Japan 411-8540
has an ability to assemble DNA fragments with homologous overlapping sequences of 15-40 bp at each end. Several modified protocols have already been reported to improve this simple and useful DNA-cloning technology. However, the molecular mechanism by which accomplishes such cloning is still unknown. Read More
JMIR Res Protoc 2018 Dec 10;7(12):e10900. Epub 2018 Dec 10.
National Hospital of Sri Lanka, Colombo, Sri Lanka.
Background: Visual impairment and blindness from diabetic retinopathy (DR), which can be reduced by early screening and treatment, is an emerging public health concern in low-income and middle-income countries (LMICs) owing to the increasing prevalence of diabetes mellitus (DM). However, no systematic screening exists in most LMIC settings. The Western province of Sri Lanka has the highest prevalence of DM (18. Read More
J Med Internet Res 2018 Dec 10;20(12):e11682. Epub 2018 Dec 10.
School of Information, The University of Texas at Austin, Austin, TX, United States.
Background: Mobile health (mHealth) technology holds promise for promoting health education and reducing health disparities and inequalities in underserved populations. However, little research has been done to develop mHealth interventions for family caregivers of people with dementia, particularly those in rural Hispanic communities, who often serve as surrogate decision makers for their relatives with dementia.
Objective: As part of a larger project to develop and test a novel, affordable, and easy-to-use mHealth intervention to deliver individually tailored materials in rural Hispanic communities, in this pilot study, we aimed to examine (1) characteristics of people with dementia and their family caregivers in rural Hispanic communities, (2) caregivers' preferences for types and amounts of health information and participation in surrogate decision making, and (3) caregivers' mobile device usage and their desire for receiving information via mobile devices. Read More
Biomed Pharmacother 2018 Dec 5;110:420-430. Epub 2018 Dec 5.
Department of Physiology, School of Medicine, Shihezi University and the Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi, 832002, China.
Aim: The Wnt/β-catenin signaling pathway plays an important role in ischemia-reperfusion(I/R) injury, and the transforming growth factor(TGF)-β/Smad signaling pathway participates in the neuroprotection effect induced by isoflurane(ISO) postconditioning. In this study, we aimed to explore the role of the Wnt/|[beta]|-catenin β-catenin signaling pathway in the neuroprotection effect induced by ISO postconditioning, and investigate the interaction of Wnt/β-catenin and TGF-β/Smad signaling pathway in this neuroprotection effect.
Methods: Cerebral I/R injury was established in Sprague-Dawley rats by using the middle cerebral artery occlusion (MCAO) model for 90 min followed by 24 h reperfusion. Read More
Clin Gastroenterol Hepatol 2018 Dec 6. Epub 2018 Dec 6.
Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390.
Background & Aims: Advanced liver disease, which includes fibrosis and cirrhosis, has been reported to be more prevalent in Hispanics patients at the time of diagnosis of chronic hepatitis C virus (HCV) infection than non-Hispanic black or non-Hispanic white patients. We performed a propensity score-matched analysis to determine whether metabolic risk factors contribute to this disparity.
Methods: We collected data from persons with 748 HCV infection (22% Hispanic, 53% non-Hispanic black, and 26% non-Hispanic while; 23% with advanced liver disease), born from 1945 through 1965, diagnosed at 6 healthcare systems in Texas. Read More
J Environ Manage 2018 Dec 4;232:751-758. Epub 2018 Dec 4.
George Perkins Marsh Institute, Clark University, Worcester, MA, 01610, USA. Electronic address:
Viewed as coupled natural and human systems, urbanizing forested landscapes exhibit fascinating and complex dynamics, where landowner decisions and biophysical processes together influence conservation and development outcomes. To improve understanding of land management decisions and conservation opportunities on private lands in these landscapes, we developed a landowner typology that accounts for heterogeneity among landowners that goes beyond ownership objectives and investigated its usefulness in predicting individual private landowners' stated intentions to implement diverse land management actions. Using survey responses collected from private landowners in two metropolitan areas in Maine, USA, we focused on understanding differences in owners' stated likelihood of implementing four conservation practices (i. Read More
Ann Emerg Med 2018 Dec 7. Epub 2018 Dec 7.
David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Emergency Medicine, UCLA-Ronald Reagan/Olive View, Los Angeles, CA.
Study Objective: Research in basic, translational, and clinical emergency medicine has made great strides since the formalization of emergency medicine as a specialty. Our objective is to identify and analyze strategies used by emergency medicine research pioneers to inform further advancement of research in emergency medicine, particularly for aspiring researchers and those in emerging areas, using emergency medicine medical education as one example.
Methods: This was a prospective, grounded-theory, qualitative study, using a constructivist/interpretivist paradigm. Read More
Transl Res 2018 Nov 20. Epub 2018 Nov 20.
Department of Biochemistry and Immunology, FMRP, University of São Paulo, Ribeirão Preto, SP, Brazil; Center for Cell Based Therapy, Hemotherapy Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil. Electronic address:
Despite all the advances in understanding the mechanisms involved in ovarian cancer (OC) development, many aspects still need to be unraveled and understood. Tumor markers (TMs) are of special interest in this disease. Some aspects of clinical management of OC might be improved by the use of validated TMs, such as differentiating subtypes, defining the most appropriate treatment, monitoring the course of the disease, or predicting clinical outcome. Read More
Int J Biol Macromol 2018 Dec 6. Epub 2018 Dec 6.
Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University of Tehran (IAUPS), Tehran, Iran.. Electronic address:
Nickel oxide nanoparticles (NiO NPs) have been used in the biological and medical sciences. However, their toxic effects against biological systems such as nervous system have not been well studied. Therefore, the adverse effect of NiO NPs on tau structure was investigated by fluorescence and CD spectroscopic methods as well as TEM study. Read More
Behav Brain Res 2018 Dec 6. Epub 2018 Dec 6.
Department of Psychology & Graduate Department of Psychological Clinical Science, University of Toronto Scarborough, Scarborough, Ontario, Canada.
Attempts to determine the cognitive benefits of adaptive working memory training in healthy adults has resulted in a polarized and stagnating field. Heterogeneous approaches and problematic methodological choices have contributed to the controversy. Structural neuroimaging has the potential to identify biological changes present after working memory training, which could go undetected by cognitive outcome tasks. Read More
Eur J Surg Oncol 2018 Dec 1. Epub 2018 Dec 1.
Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
The treatment of tumors with electrochemotherapy (ECT) has surged over the past decade. Thanks to the transient cell membrane permeabilization induced by the short electric pulses used by ECT, cancer cells are exposed to otherwise poorly permeant chemotherapy agents, with consequent increased cytotoxicity. The codification of the procedure in 2006 led to a broad diffusion of the procedure, mainly in Europe, and since then, the progressive clinical experience, together with the emerging technologies, have extended the range of its application. Read More
Patient Educ Couns 2018 Nov 15. Epub 2018 Nov 15.
LOROS Hospice Care for Leicestershire and Rutland, and Medicine University Hospitals Leicester, UK.
Objective: Giving terminally ill people opportunities to participate in advance care planning involves tensions between: endorsing and supporting patients' expectations, plans and decisions, and addressing how realistic these are. The latter risks exerting undue pressure to change plans; undermining autonomy; jeopardising therapeutic relationships. Our objective is to describe how experienced hospice doctors raise potential/actual problems with patients' expectations, plans or decisions. Read More
Brachytherapy 2018 Dec 6. Epub 2018 Dec 6.
Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea; Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
Purpose: The purpose of this study was to develop a patient-specific elastic skin applicator and to evaluate its dosimetric characteristics for high-dose-rate (HDR) brachytherapy.
Methods And Materials: We simulated the treatment of a nonmelanoma skin cancer on the nose. An elastic skin applicator was manufactured by pouring the Dragon Skin (Smooth-On Inc. Read More
Lancet Diabetes Endocrinol 2018 Oct 24. Epub 2018 Oct 24.
Peter Gorer Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, UK; King's Health Partners Institute of Diabetes, Obesity and Endocrinology, London, UK.
With the conceptual advance about four decades ago that type 1 diabetes represents an autoimmune disease, hope arose that immune-based therapies would soon emerge to prevent and reverse the disorder. However, despite dozens of clinical trials seeking to achieve these goals, the promise remains unfulfilled, at least in a pragmatic form. With the benefit of hindsight, several important reasons are likely to account for this disappointing outcome, including failure to appreciate disease heterogeneity, inappropriate use of rodent models of disease, inadequacies in addressing the immunological and metabolic contributions to the disease, suboptimal trial designs, and lack of a clear understanding of the pathogenesis of type 1 diabetes. Read More
J Dairy Sci 2018 Oct 24. Epub 2018 Oct 24.
University of Liverpool, Leahurst Campus, Neston, Wirral, CH64 7TE, United Kingdom.
Understanding the changes that have occurred in reproductive management and physiology of the dairy cow is necessary to reverse the trend of declining fertility. In this study we analyzed the intervals between estrus events, as detected using tail chalk, in a population of 6,092 dairy cows from 16 herds in the central United Kingdom. Intervals were categorized by absence or presence of an insemination at the first estrus event, being designated interestrus intervals and interservice intervals, respectively. Read More
J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Cook, Bloomington, Indiana.
Purpose: A prospective, single-center, single-arm feasibility study evaluated procedural and short-term performance of the Advance Enforcer 35 focal-force percutaneous transluminal angioplasty (PTA) balloon catheter in treating stenoses of mature native arteriovenous (AV) hemodialysis access circuits.
Materials And Methods: Twenty-eight patients undergoing treatment for stenosis of a mature native AV hemodialysis access circuit were enrolled at a single institution. Angiographic assessments of the study lesion were required at baseline and after the procedure. Read More
J Prosthet Dent 2018 Dec 4. Epub 2018 Dec 4.
CDT, Department of Prosthetic Dentistry, University Hospital, LMU Munich, München, Germany.
Statement Of Problem: Determining the relationship between variable thicknesses and the translucency of dental ceramics is essential for optimizing esthetics in different clinical situations.
Purpose: The purpose of this in vitro study was to analyze the relationship between layer thickness and translucency of 2 multi-layered monolithic zirconia materials and to develop an equation by which the grade of translucency can be calculated dependent on the materials' layer thicknesses in advance.
Material And Methods: Two semisintered multi-layered zirconia blanks, namely KATANA Zirconia Super Translucent Multi-Layered Disk (Noritake Dental Supply Co, Ltd) and Zirconia Ultra Translucent Multi-Layered Disk (UTML) (Noritake Dental Supply Co, Ltd), were sectioned (N=96) to separate the 4 layers (n=12 per layer): enamel layer, transition layer 1, transition layer 2, body layer. Read More
Biophys J 2018 Nov 10. Epub 2018 Nov 10.
College of Engineering and Informatics, National University of Ireland Galway, Galway, Republic of Ireland. Electronic address:
Biological spread cells exist in a perpetually fluctuating state and therefore cannot be described in terms of a unique deterministic system. For modeling approaches to provide novel insight and uncover new mechanisms that drive cell behavior, a framework is required that progresses from traditional deterministic methods (whereby simulation of an experiment predicts a single outcome). In this study, we implement a new, to our knowledge, modeling approach for the analysis of cell spreading on ligand-coated substrates, extending the framework for nonequilibrium thermodynamics of cells developed by Shishvan et al. Read More
Curr Pharm Teach Learn 2018 Oct 30;10(10):1419-1428. Epub 2018 Aug 30.
School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, County Antrim BT9 7BL, Northern Ireland. Electronic address:
Background And Purpose: To design and critically evaluate a laboratory-scale pharmaceutical formulation practical that enables pharmaceutical science students to develop work-based skills relating to industrial pharmacy such as problem solving, pharmaceutical calculations, research, legal checking, communication, practical aptitude, handling of medicinal products, record keeping, and ability to interpret, analyze and report data.
Educational Activity And Setting: Nine laboratory practical sessions were designed whereby students formulated a range of dosage forms and conducted corrective and preventative actions (CAPAs) exercises. A master batch formula outlined the specifications for each product and a practical sheet was provided for the students to record their activities. Read More