218 results match your criteria Advance for NPs & PAs[Journal]


Behavioural issues in late life may be the precursor of dementia- A cross sectional evidence from memory clinic of AIIMS, India.

PLoS One 2020 10;15(6):e0234514. Epub 2020 Jun 10.

Department of Geriatric medicine, All India Institute of Medical Science, New Delhi, India.

Background: Mild Behavioural Impairment (MBI), an "at risk" state for incident cognitive declin, is characterized by late onset, sustained neuropsychiatric symptoms of any severity which cannot be accounted for by other formal medical and psychiatric nosology. There is no study related to MBI from India.

Methods And Findings: In this cross-sectional observational study 124 subjects 60 years and above were recruited between March 2017 to October 2018, from memory clinic of department of Geriatric medicine with memory or behavioural complains. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234514PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286493PMC

Single-cell Transcriptome Analysis Indicates New Potential Regulation Mechanism of ACE2 and NPs signaling among heart failure patients infected with SARS-CoV-2.

medRxiv 2020 May 15. Epub 2020 May 15.

Integrative Bioinformatics, ESCBL, NIEHS, National Institutes of Health, Research Triangle Park, NC, 27709, USA.

Background: COVID-19 patients with comorbidities such as hypertension or heart failure (HF) are associated with poor clinical outcomes. Angiotensin-converting enzyme 2 (ACE2), the critical enzyme for SARS-CoV-2 infection, is broadly expressed in many organs including heart. However, the cellular distribution of ACE2 in the human heart, particularly the failing heart is unknown. Read More

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http://dx.doi.org/10.1101/2020.04.30.20081257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241106PMC

Oxygen-producing catalase-based prodrug nanoparticles overcoming resistance in hypoxia-mediated chemo-photodynamic therapy.

Acta Biomater 2020 Jun 2. Epub 2020 Jun 2.

Engineering Research Center for Biomedical Materials, Anhui Key Laboratory of Modern Biomanufacturing, School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei, Anhui Province, 230601, PR China. Electronic address:

Extreme hypoxia inside solid tumors is the primary barrier against the advance of chemotherapy and photodynamic therapy (PDT). To address this problem, a hybrid nano-enzyme prodrug system was developed to alleviate hypoxia as well as simultaneously sensitize chemo-photodynamic therapy. Lactobionic acid (LA) and doxorubicin (DOX) precursor (cis-aconitic anhydride-linked doxorubicin, CAD) were pre-conjugated onto the side chain of catalase (CAT), then co-assembled with chlorin e6 (Ce6) to form LA-CAT-CAD@Ce6 nanoparticles (LCC@Ce6-NPs). Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.035DOI Listing
June 2020
6.025 Impact Factor

Hyaluronic Acid-Modified Au-Ag Alloy Nanoparticles for Radiation/Nanozyme/Ag Multimodal Synergistically Enhanced Cancer Therapy.

Bioconjug Chem 2020 Jun 11. Epub 2020 Jun 11.

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.

Gold nanoparticles (AuNPs) have been widely documented as tumor radiosensitizers via enhanced energy deposition of ionizing radiation. However, the sensitization efficiency of AuNPs is still far from satisfactory owing to the irradiation on nontarget tissues and the tumor radio-resistance. To address these issues, we report herein the rational design and development of hyaluronic acid-modified Au-Ag alloy nanoparticles (Au-Ag@HA NPs) with effective tumor radiosensitization by receptor mediated tumor targeting as well as microenvironment-activated hydroxyl radicals (•OH) generation. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00224DOI Listing

Label-free and enzyme-free one-step rapid colorimetric detection of DNA methylation based on unmodified gold nanoparticles.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Sep 15;238:118375. Epub 2020 Apr 15.

Department of Chemistry, Nanchang University, Nanchang 330031, PR China. Electronic address:

DNA methylation has been identified as one of the important causes of tumorigenesis, so it is important to develop some advanced methods for detecting and quantifying DNA methylation. In this study, a label-free and enzyme-free one-step rapid colorimetric detection of DNA methylation based on unmodified Au nanoparticles(Au NPs)has been proposed. This method can quickly, efficiently, economically and easily colorimetric detect methylated DNA only by the color change of unmodified Au NPs solution without the covalent modification of Au NPs in advance or complicated instruments for implementation with practical limitations or expensive biological enzymes or traditional organic dyes during the reaction. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118375DOI Listing
September 2020

Tumor Targeting by αβ-Integrin-Specific Lipid Nanoparticles Occurs Phagocyte Hitchhiking.

ACS Nano 2020 May 20. Epub 2020 May 20.

Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway.

Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles' (NP) behavior is complex and the immune system's role in their application remains elusive. At present, only passive-targeting nanoformulations have been clinically approved, while more complicated active-targeting strategies typically fail to advance from the early clinical phase stage. This absence of clinical translation is, among others, due to the very limited understanding for targeting mechanisms. Read More

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http://dx.doi.org/10.1021/acsnano.9b08693DOI Listing

Nanoporous iron oxide nanoparticle: hydrothermal fabrication, human serum albumin interaction and potential antibacterial effects.

J Biomol Struct Dyn 2020 Apr 15:1-12. Epub 2020 Apr 15.

Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, Qatar.

Nanoporous iron oxide (FeO) nanoparticles (NIONPs) have been widely used as promising agents in biomedical applications. Herein, the NIONPs were synthesized by one-step hydrothermal method and well-characterized by FESEM and TEM investigations. Afterwards, their interaction with human serum albumin (HSA) was studied using a wide range of biophysical approaches, including intrinsic and extrinsic fluorescence, far and near UV-CD, and UV-Vis spectroscopic methods as well as molecular docking investigation. Read More

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http://dx.doi.org/10.1080/07391102.2020.1751296DOI Listing

Nanoparticle-based targeted delivery of pentagalloyl glucose reverses elastase-induced abdominal aortic aneurysm and restores aorta to the healthy state in mice.

PLoS One 2020 27;15(3):e0227165. Epub 2020 Mar 27.

Department of Bioengineering, Clemson University, Clemson, SC, United States of America.

Aim: Abdominal aortic aneurysms (AAA) is a life-threatening weakening and expansion of the abdominal aorta due to inflammatory cell infiltration and gradual degeneration of extracellular matrix (ECM). There are no pharmacological therapies to treat AAA. We tested the hypothesis that nanoparticle (NP) therapy that targets degraded elastin and delivers anti-inflammatory, anti-oxidative, and ECM stabilizing agent, pentagalloyl glucose (PGG) will reverse advance stage aneurysm in an elastase-induced mouse model of AAA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227165PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100957PMC
May 2020
3.234 Impact Factor

Amide-Assisted Synthesis of Iron Germanium Sulfide (FeGeS) Nanostars: The Effect of LiN(SiMe) on Precursor Reactivity for Favoring Nanoparticle Nucleation or Growth.

J Am Chem Soc 2020 Apr 6;142(15):7023-7035. Epub 2020 Apr 6.

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.

Olivine FeGeS has been identified as a promising photovoltaic absorber material introduced as an alternate candidate to iron pyrite, FeS. The compounds share similar benefits in terms of elemental abundance and relative nontoxicity, but FeGeS was predicted to have higher stability with respect to decomposition to alternate phases and, therefore, more optimal device performance. Our initial report of the nanoparticle (NP) synthesis for FeGeS was not well understood and required an inefficient 24 h growth to dissolve an iron sulfide impurity. Read More

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http://dx.doi.org/10.1021/jacs.0c00260DOI Listing

Nanoparticle depots for controlled and sustained gene delivery.

J Control Release 2020 Jun 16;322:622-631. Epub 2020 Mar 16.

Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA; Department of Biomedical Engineering, New Jersey Institute of Technology, 323 Dr Martin Luther King Jr Blvd, Newark, NJ 07102, USA. Electronic address:

Gene therapy is one of the most promising medical fields which holds the potential to rapidly advance the treatment of difficult ailments such as cancer as well as inherited genetic diseases. However, clinical translation is limited by several drug delivery hurdles including renal clearance, phagocytosis, enzymatic degradation, protein absorption, as well as cellular internalization barriers. Additionally, successful treatments require sustained release of drug payloads to maintain the effective therapeutic level. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.03.021DOI Listing
June 2020
7.705 Impact Factor

Nanocomposite bioink exploits dynamic covalent bonds between nanoparticles and polysaccharides for precision bioprinting.

Biofabrication 2020 03 13;12(2):025025. Epub 2020 Mar 13.

Tissue Engineering and Biofabrication Laboratory, Department of Health Sciences & Technology, ETH Zürich, Otto-Stern-Weg 7, 8093 Zürich, Switzerland.

The field of bioprinting has made significant recent progress towards engineering tissues with increasing complexity and functionality. It remains challenging, however, to develop bioinks with optimal biocompatibility and good printing fidelity. Here, we demonstrate enhanced printability of a polymer-based bioink based on dynamic covalent linkages between nanoparticles (NPs) and polymers, which retains good biocompatibility. Read More

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http://dx.doi.org/10.1088/1758-5090/ab782dDOI Listing

Nanoparticles for "two color" F magnetic resonance imaging: Towards combined imaging of biodistribution and degradation.

J Colloid Interface Sci 2020 Apr 18;565:278-287. Epub 2019 Dec 18.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 26/28, 6525 GA Nijmegen, the Netherlands. Electronic address:

The use of polymeric nanoparticles (NPs) as therapeutics has been steadily increasing over past decades. In vivo imaging of NPs is necessary to advance the therapeutic performance. F Magnetic Resonance Imaging (F MRI) offers multiple advantages for in vivo imaging. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.12.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058420PMC

ChABC-loaded PLGA nanoparticles: A comprehensive study on biocompatibility, functional recovery, and axonal regeneration in animal model of spinal cord injury.

Int J Pharm 2020 Mar 15;577:119037. Epub 2020 Jan 15.

College of Pharmacy, Nova Southeastern University, USA.

Spinal Cord Injury (SCI) is one of the leading causes of physical disability. In this study, spherical PLGA nanoparticles (NPs) containing ChABC enzyme were manufactured and fully characterized for SCI therapy. The NPs were used in the rat's contused spinal cord to assess the functional improvement and scar digestion. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119037DOI Listing

Organic Polymer Nanoparticles with Primary Ammonium Salt as Potent Antibacterial Nanomaterials.

ACS Appl Mater Interfaces 2020 May 7;12(19):21254-21262. Epub 2020 Jan 7.

School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P.R. China.

Bacterial infections induced by drug-resistant strains have become a global crisis. A membrane-disrupted mechanism is considered as an effective way to kill bacteria with little chance to trigger drug resistance. It is necessary to explore and develop new materials based on the membrane-disrupted mechanism to combat bacterial resistance. Read More

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http://dx.doi.org/10.1021/acsami.9b19921DOI Listing

Advance on toxicity of metal nickel nanoparticles.

Authors:
Yongya Wu Lu Kong

Environ Geochem Health 2020 Jan 1. Epub 2020 Jan 1.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China.

As a kind of conventional metal nanomaterial, nickel nanoparticles (Ni NPs) have broad application prospects in the fields of magnetism, energy technology and biomedicine and have quickly attracted great interest. The potential negative effects of Ni NPs have also attracted wide attention from some researchers. Studies have shown that Ni NPs cause a variety of toxic effects on cells, animals and humans and have toxic effects of multiple systems such as respiratory system, cardiovascular system and reproductive system. Read More

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http://dx.doi.org/10.1007/s10653-019-00491-4DOI Listing
January 2020

Revisiting Criteria for Psychosis in Alzheimer's Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research.

J Alzheimers Dis 2020 ;73(3):1143-1156

Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.

Background: Psychotic symptoms are common in Alzheimer's disease (AD) and related neurodegenerative disorders and are associated with more rapid disease progression and increased mortality. It is unclear to what degree existing criteria are utilized in clinical research and practice.

Objective: To establish research criteria for the diagnosis of psychosis in AD. Read More

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http://dx.doi.org/10.3233/JAD-190828DOI Listing
January 2020
4.151 Impact Factor

Overcoming the Brain Barriers: From Immune Cells to Nanoparticles.

Trends Pharmacol Sci 2020 Jan 12;41(1):42-54. Epub 2019 Dec 12.

Department of Neuroscience, Faculty of Medicine, Université de Montréal, and Neuroimmunology Unit, Centre de Recherche du CHUM (CRCHUM), Montréal, QC, Canada. Electronic address:

Nanoparticulate carriers, often referred to as nanoparticles (NPs), represent an important pharmacological advance for drug protection and tissue-specific drug delivery. Accessing the central nervous system (CNS), however, is a complex process regulated by mainly three brain barriers. While some leukocyte (i. Read More

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http://dx.doi.org/10.1016/j.tips.2019.11.001DOI Listing
January 2020

Palladium nanosheet-knotted injectable hydrogels formed via palladium-sulfur bonding for synergistic chemo-photothermal therapy.

Nanoscale 2020 Jan 9;12(1):210-219. Epub 2019 Dec 9.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, P. R. China.

Nanoparticle (NP)-based hydrogels that can introduce synergistic advantages to the novel three-dimensional scaffold have garnered much attention recently. However, the application of NP-crosslinked hydrogels still remains challenging due to the complicated synthesis and/or modification of the NPs and the changed properties of the NPs after gelation. Herein, a novel palladium nanosheet (Pd NS)-based hydrogel (Pd Gel) with Pd NSs as crosslinkers was obtained by simply mixing Pd NSs with thiol-terminated four-arm polyethylene glycol (4arm-PEG-thiol). Read More

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http://dx.doi.org/10.1039/c9nr08454aDOI Listing
January 2020

Cell-Selective Messenger RNA Delivery and CRISPR/Cas9 Genome Editing by Modulating the Interface of Phenylboronic Acid-Derived Lipid Nanoparticles and Cellular Surface Sialic Acid.

ACS Appl Mater Interfaces 2019 Dec 9;11(50):46585-46590. Epub 2019 Dec 9.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems , Institute of Chemistry Chinese Academy of Sciences , Beijing 100190 , China.

Messenger RNA (mRNA) represents an emerging class of nucleic acid therapeutics for genome editing and genetic disease treatment. Delivering exogenous mRNA selectively to cells, however, remains a main challenge to broaden the biomedical application of mRNA and develop targeted gene therapy. Herein, we report cell-selective mRNA delivery and CRISPR/Cas9 genome editing by modulating the interface of phenylboronic acid (PBA) derived lipid nanoparticles (NPs) and cellular surface sialic acid (SA). Read More

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http://dx.doi.org/10.1021/acsami.9b17749DOI Listing
December 2019

Current computational methods for predicting protein interactions of natural products.

Comput Struct Biotechnol J 2019 28;17:1367-1376. Epub 2019 Oct 28.

Institute of Pharmaceutical Sciences, Research Group Pharmaceutical Bioinformatics, Albert-Ludwigs-Universität Freiburg, Germany.

Natural products (NPs) are an indispensable source of drugs and they have a better coverage of the pharmacological space than synthetic compounds, owing to their high structural diversity. The prediction of their interaction profiles with druggable protein targets remains a major challenge in modern drug discovery. Experimental (off-)target predictions of NPs are cost- and time-consuming, whereas computational methods, on the other hand, are much faster and cheaper. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861622PMC
October 2019

Nanomedicine Against Aβ Aggregation by β-Sheet Breaker Peptide Delivery: In Vitro Evidence.

Pharmaceutics 2019 Nov 1;11(11). Epub 2019 Nov 1.

Cellular Neurobiology and Neuro-Nanotechnology lab, Department of Biological Sciences, University of Limerick, Limerick, V94PH61, Ireland.

The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer's disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability to cross the blood-brain barrier. Read More

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http://dx.doi.org/10.3390/pharmaceutics11110572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920811PMC
November 2019
1 Read

Evidence for decreased Neurologic Pain Signature activation following thoracic spinal manipulation in healthy volunteers and participants with neck pain.

Neuroimage Clin 2019 18;24:102042. Epub 2019 Oct 18.

Center of Expertise, Rehabilitation and Occupational Health, OSF HealthCare, Peoria, IL, United States; School of Physical Therapy, South College, Knoxville, TN, United States.

Background Context: Spinal manipulation (SM) is a common treatment for neck and back pain, theorized to mechanically affect the spine leading to therapeutic mechanical changes. The link between specific mechanical effects and clinical improvement is not well supported. SM's therapeutic action may instead be partially mediated within the central nervous system. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.102042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831903PMC
October 2019
4 Reads

Suppressing Ammonia Re-Emission with the Aid of the CoO-NPs@KIT-6 Catalyst in Ammonia-Based Desulfurization.

Environ Sci Technol 2019 Nov 7;53(22):13477-13485. Epub 2019 Nov 7.

College of Environment , Zhejiang University of Technology , Hangzhou 310014 , Zhejiang , China.

The re-emission of NH and SO caused by the decomposition of (NH)SO is a crucial concern in ammonia-based desulfurization. In this study, a novel CoO-NPs@KIT-6 catalyst with a three-dimensional two-helix structure is proposed for converting (NH)SO into (NH)SO. The oxidation rate of (NH)SO with the catalyst was 7. Read More

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http://dx.doi.org/10.1021/acs.est.9b03060DOI Listing
November 2019

Biocompatibility in regenerative nanomedicine.

Nanomedicine (Lond) 2019 10 15;14(20):2763-2775. Epub 2019 Oct 15.

Wake Forest School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA.

Biocompatibility is a very common word that is used within biomaterial science and used for description of the interactions between the foreign material and the body. However, the meaning of biocompatibility as well as the mechanisms that collectively constitutes is still unclear. With the advance of nanotechnology, new concerns have been observed related to biocompatibility of these biomaterials. Read More

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http://dx.doi.org/10.2217/nnm-2019-0140DOI Listing
October 2019

Effects of cartilage-targeting moieties on nanoparticle biodistribution in healthy and osteoarthritic joints.

Acta Biomater 2020 01 4;101:469-483. Epub 2019 Oct 4.

University of Florida, J. Crayton Pruitt Family Department of Biomedical Engineering, 1275 Center Drive, Biomedical Sciences Building, JG-56, Gainesville, FL 32611, United States. Electronic address:

Understanding intra-articular biodistribution is imperative as candidate osteoarthritis (OA) drugs become increasingly site-specific. Cartilage has been identified as opportunistic for therapeutic intervention, but poses numerous barriers to drug delivery. To facilitate drug delivery to cartilage, nanoscale vehicles have been designed with different features that target the tissue's matrix. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025912PMC
January 2020
1 Read

Confining Iron Oxide Nanocubes inside Submicrometric Cavities as a Key Strategy To Preserve Magnetic Heat Losses in an Intracellular Environment.

ACS Appl Mater Interfaces 2019 Nov 31;11(45):41957-41971. Epub 2019 Oct 31.

Istituto Italiano di Tecnologia , Via Morego 30 , 16163 Genova , Italy.

The design of magnetic nanostructures whose magnetic heating efficiency remains unaffected at the tumor site is a fundamental requirement to further advance magnetic hyperthermia in the clinic. This work demonstrates that the confinement of magnetic nanoparticles (NPs) into a sub-micrometer cavity is a key strategy to enable a certain degree of nanoparticle motion and minimize aggregation effects, consequently preserving the magnetic heat loss of iron oxide nanocubes (IONCs) under different conditions, including intracellular environments. We fabricated magnetic layer-by-layer (LbL) self-assembled polyelectrolyte sub-micrometer capsules using three different approaches, and we studied their heating efficiency as obtained in aqueous dispersions and after internalization by tumor cells. Read More

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http://dx.doi.org/10.1021/acsami.9b15501DOI Listing
November 2019
1 Read

Graphite carbon-encapsulated metal nanoparticles derived from Prussian blue analogs growing on natural loofa as cathode materials for rechargeable aluminum-ion batteries.

Sci Rep 2019 Sep 20;9(1):13665. Epub 2019 Sep 20.

Department of Materials Science and Engineering, Research Institute of Advanced Materials, Seoul National University, Seoul, 08826, Republic of Korea.

Aluminum-ion batteries (AIBs) are attracting increasing attention as a potential energy storage system owing to the abundance of Al sources and high charge density of Al. However, suitable cathode materials to further advance high-performing AIBs are unavailable. Therefore, we demonstrated the compatibility of elemental metal nanoparticles (NPs) as cathode materials for AIBs. Read More

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http://dx.doi.org/10.1038/s41598-019-50154-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754498PMC
September 2019

Electrospinning Nanoparticles-Based Materials Interfaces for Sensor Applications.

Sensors (Basel) 2019 Sep 14;19(18). Epub 2019 Sep 14.

State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing 100029, China.

Electrospinning is a facile technique to fabricate nanofibrous materials with adjustable structure, property, and functions. Electrospun materials have exhibited wide applications in the fields of materials science, biomedicine, tissue engineering, energy storage, environmental science, sensing, and others. In this review, we present recent advance in the fabrication of nanoparticles (NPs)-based materials interfaces through electrospinning technique and their applications for high-performance sensors. Read More

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http://dx.doi.org/10.3390/s19183977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767230PMC
September 2019

Remarkable Effect of Jacalin in Diminishing the Protein Corona Interference in the Antibacterial Activity of Pectin-Capped Copper Sulfide Nanoparticles.

ACS Omega 2019 Aug 15;4(9):14049-14056. Epub 2019 Aug 15.

School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India.

Herein, we report a new strategy based on jacalin functionalization to diminish the impact of biological fluids in the antibacterial applications of nanoparticles (NPs). Precoating pectin-capped copper sulfide NPs (pCuS) with bovine serum albumin produced a protein corona, which affects the antibacterial activity of pCuS. It was found that the minimum inhibitory concentration (MIC) increases fourfold because of the formation of the protein corona. Read More

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http://dx.doi.org/10.1021/acsomega.9b01886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714611PMC

Metal Organic Frameworks as Robust Host of Palladium Nanoparticles in Heterogeneous Catalysis: Synthesis, Application, and Prospect.

ACS Appl Mater Interfaces 2019 Sep 29;11(36):32579-32598. Epub 2019 Aug 29.

College of Environmental Science and Engineering , Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University) , Ministry of Education, Changsha 410082 , People's Republic of China.

Metal organic frameworks (MOFs) are one set of the most excellent supports for Pd nanoparticles (NPs). MOFs as the host mainly have the following advantages: (i) they provide size limits for highly dispersed Pd NPs; (ii) fixing Pd NPs is beneficial for separation and reuse, avoiding the loss of expensive metals; (iii) the MOFs skeleton is diversified and functionalized, which is beneficial to enhancing the interaction with Pd NPs and prolonging the service life of the catalyst. This review discusses the synthesis strategy of Pd@MOF, which provides guidance for the synthesis of similar materials. Read More

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http://dx.doi.org/10.1021/acsami.9b11990DOI Listing
September 2019
2 Reads

The interaction of silica nanoparticles with catalase and human mesenchymal stem cells: biophysical, theoretical and cellular studies.

Int J Nanomedicine 2019 16;14:5355-5368. Epub 2019 Jul 16.

Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Aim: Nanoparticles (NPs) have been receiving potential interests in protein delivery and cell therapy. As a matter of fact, NPs may be used as great candidates in promoting cell therapy by catalase (CAT) delivery into high oxidative stress tissues. However, for using NPs like SiO as carriers, the interaction of NPs with proteins and mesenchymal stem cells (MSCs) should be explored in advance. Read More

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http://dx.doi.org/10.2147/IJN.S210136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643057PMC
October 2019
1 Read

Does expanded state scope of practice for nurse practitioners and physician assistants increase primary care utilization in community health centers?

J Am Assoc Nurse Pract 2020 Jun;32(6):447-458

Health Policy and Management, Milken Institute School of Public Health, The George Washington University, Washington, DC.

Background And Purpose: Expanding state scope of practice (SOP) for nurse practitioners (NPs) and physician assistants (PAs) can boost productivity and improve access to health care services. Existing analyses on regulatory policies in NP or PA SOP have primarily focused on the direct effects on their own professions but have not fully considered the potential cross-professional effects. This study examines the impact of expanded state SOP for NPs and PAs on primary care utilization by NP, PA, and primary care physician (PCP) in community health centers (CHCs). Read More

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http://dx.doi.org/10.1097/JXX.0000000000000263DOI Listing

Tuning the ultrasonic and photoacoustic response of polydopamine-stabilized perfluorocarbon contrast agents.

J Mater Chem B 2019 08;7(31):4833-4842

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

Contrast-enhanced ultrasound (CEUS) offers the exciting prospect of retaining the ease of ultrasound imaging while enhancing imaging clarity, diagnostic specificity, and theranostic capability. To advance the capabilities of CEUS, the synthesis and understanding of new ultrasound contrast agents (UCAs) is a necessity. Many UCAs are nano- or micro-scale materials composed of a perfluorocarbon (PFC) and stabilizer that synergistically induce an ultrasound response that is both information-rich and easily differentiated from natural tissue. Read More

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http://dx.doi.org/10.1039/c9tb00928kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690494PMC
August 2019
1 Read

Research translation and the evolving PhD and DNP practice roles: A collaborative call for nurse practitioners.

J Am Assoc Nurse Pract 2019 Aug;31(8):447-453

Department of Nursing Research, Gundersen Health System/Gundersen Medical Foundation, La Crosse, Wisconsin.

Doctoral prepared nurse practitioners (NPs) are uniquely positioned for responsible leadership as essential members of the health care system and have a professional responsibility to contribute to research and clinical inquiry initiatives that advance health care delivery and improve outcomes. Academic preparation of the Doctor of Philosophy (PhD) and Doctor of Nursing Practice (DNP), although different in focus, offers opportunities for effective collaborations that transcend and integrate the scientific and practice roles of generating data and translating evidence. As health care organizations evolve in managing complexities of providing high-quality care, roles for the PhD as research scientist and DNP as research translation specialist will also evolve to keep pace. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000266DOI Listing
August 2019
1 Read

Psychosocial information use for clinical decisions in diabetes care.

J Am Med Inform Assoc 2019 08;26(8-9):813-824

School of Information, School of Public Health, University of Michigan, Ann Arbor, Michigan USA.

Objective: There are increasing efforts to capture psychosocial information in outpatient care in order to enhance health equity. To advance clinical decision support systems (CDSS), this study investigated which psychosocial information clinicians value, who values it, and when and how clinicians use this information for clinical decision-making in outpatient type 2 diabetes care.

Materials And Methods: This mixed methods study involved physician interviews (n = 17) and a survey of physicians, nurse practitioners (NPs), and diabetes educators (n = 198). Read More

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http://dx.doi.org/10.1093/jamia/ocz053DOI Listing
August 2019
5 Reads

Molecular Targeting-Mediated Mild-Temperature Photothermal Therapy with a Smart Albumin-Based Nanodrug.

Small 2019 08 7;15(33):e1900501. Epub 2019 Jul 7.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, 210096, P. R. China.

Photothermal therapy (PTT) usually requires hyperthermia >50 °C for effective tumor ablation, which inevitably induces heating damage to the surrounding normal tissues/organs. Moreover, low tumor retention and high liver accumulation are the two main obstacles that significantly limit the efficacy and safety of many nanomedicines. To solve these problems, a smart albumin-based tumor microenvironment-responsive nanoagent is designed via the self-assembly of human serum albumin (HSA), dc-IR825 (a cyanine dye and a photothermal agent), and gambogic acid (GA, a heat shock protein 90 (HSP90) inhibitor and an anticancer agent) to realize molecular targeting-mediated mild-temperature PTT. Read More

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http://dx.doi.org/10.1002/smll.201900501DOI Listing
August 2019
1 Read

Nanoparticles and Its Implications in HIV/AIDS Therapy.

Authors:
Oti Baba Victor

Curr Drug Discov Technol 2019 Jun 20. Epub 2019 Jun 20.

Department of Microbiology, Nasarawa State University, PMB 1022, Keffi. Nigeria.

The use of antiretroviral drugs to treat HIV/AIDS patients has enormously increased their life spans with serious disadvantages. The virus infection still remains a public health problem worldwide with no cure and vaccine for the viral agent until now. The use of nanoparticles (NPs) for the prevention and treatment of HIV/AIDS is an emerging technology of the 21st century. Read More

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http://dx.doi.org/10.2174/1570163816666190620111652DOI Listing
June 2019
2 Reads

Shape-dependent antimicrobial activities of silver nanoparticles.

Int J Nanomedicine 2019 23;14:2773-2780. Epub 2019 Apr 23.

Department of Advance Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 34134, Korea.

An important application of silver nanoparticles (Ag NPs) is their use as an antimicrobial and wound dressing material. The aim of this study is to investigate the morphological dependence on the antimicrobial activity and cellular response of Ag NPs. Ag NPs of various shapes were synthesized in an aqueous solution using a simple method. Read More

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https://www.dovepress.com/shape-dependent-antimicrobial-acti
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http://dx.doi.org/10.2147/IJN.S196472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499446PMC
July 2019
19 Reads

Periplasmic Nanobody-APEX2 Fusions Enable Facile Visualization of Ebola, Marburg, and Mĕnglà virus Nucleoproteins, Alluding to Similar Antigenic Landscapes among and .

Viruses 2019 04 20;11(4). Epub 2019 Apr 20.

Disease Intervention and Prevention, Texas Biomedical Research Institute, 8715 W. Military Dr., San Antonio, TX 78227-5302, USA.

We explore evolved soybean ascorbate peroxidase (APEX2) as a reporter when fused to the C-termini of llama nanobodies (single-domain antibodies, sdAb; variable domains of heavy chain-only antibodies, VHH) targeted to the periplasm. Periplasmic expression preserves authentic antibody N-termini, intra-domain disulphide bond(s), and capitalizes on efficient haem loading through the porous outer membrane. Using monomeric and dimeric anti-nucleoprotein (NP) sdAb cross-reactive within the genus and cross-reactive within the genus, we show that periplasmic sdAb-APEX2 fusion proteins are easily purified at multi-mg amounts. Read More

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https://www.mdpi.com/1999-4915/11/4/364
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http://dx.doi.org/10.3390/v11040364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521291PMC
April 2019
8 Reads

Influence of Surface Charge on the Phytotoxicity, Transformation, and Translocation of CeO Nanoparticles in Cucumber Plants.

ACS Appl Mater Interfaces 2019 May 25;11(18):16905-16913. Epub 2019 Apr 25.

Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049 , China.

The physiochemical properties of nanoparticles (NPs), including surface charge, will affect their uptake, transformation, translocation, and final fate in the environment. In this study, we compared the phytoxoxicity and transport behaviors of nano CeO (nCeO) functionalized with positively charged (Cs-nCeO) and negatively charged (PAA-nCeO) coatings. Cucumber seedlings were hydroponically exposed to 0-1000 mg/L of Cs-nCeO and PAA-nCeO for 14 days and the contents, distribution, translocation, and transformation of Ce in plants were analyzed using inductively coupled plasma mass spectrometry, micro X-ray fluorescence (μ-XRF), and X-ray absorption near-edge spectroscopy (XANES), respectively. Read More

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http://dx.doi.org/10.1021/acsami.9b01627DOI Listing
May 2019
6 Reads

Mild Behavioral Impairment: presentation of the diagnostic criteria and the Italian version of the MBI-Checklist.

Riv Psichiatr 2019 Mar-Apr;54(2):59-66

Department of Experimental and Clinical Medicine, Section of Psychiatry, University of Pisa, Italy - Institute of Behavioural Science "G. De Lisio", Pisa, Italy.

Neuropsychiatric symptoms (NPS) are common in the prodromal stage of dementia and can precede the onset of cognitive impairment. The presence of NPS in cognitively normal patients or in patients with Mild Cognitive Impairment (MCI) is associated with an increased risk of progression along the neurodegenerative process. The need to identify, in the early stages of the disease, the population at risk of cognitive decline has led to the formulation of the concept of Mild Behavioral Impairment (MBI). Read More

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http://www.rivistadipsichiatria.it/articoli.php?archivio=yes
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http://dx.doi.org/10.1708/3142.31246DOI Listing
December 2019
29 Reads

Metal nanoparticles embedded in AIEE active supramolecular assemblies: robust, green and reusable nanocatalysts.

Dalton Trans 2019 Apr;48(15):4769-4773

Department of Chemistry, UGC Sponsored Centre for Advance Studies-II, Guru Nanak Dev University, Amritsar 143005, Punjab, India.

In modern organic synthesis, the utilization of metal NPs for carrying out fundamental organic transformations is an area of great interest. This frontier article describes the exploitation of supramolecular assemblies of AIEE-active materials as nanoreactors, stabilizers and shape directing agents for the preparation of various types of metal NPs without using any additives, reducing agents, stabilizing agents, etc. This article further summarizes the utilization of the as-prepared supramolecular ensembles as reusable nanocatalysts for carrying out various organic transformations under mild conditions. Read More

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http://dx.doi.org/10.1039/c9dt00307jDOI Listing
April 2019
3 Reads
4.197 Impact Factor

Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells.

Drug Deliv Transl Res 2019 06;9(3):652-666

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.

Strategies that control the differentiation of mesenchymal stem cells (MSC) and enable image-guided cell implantation and longitudinal monitoring could advance MSC-based therapies for bone defects and injuries. Here we demonstrate a multifunctional nanoparticle system that delivers resveratrol (RESV) intracellularly to improve osteogenesis and enables photoacoustic imaging of MSCs. RESV-loaded nanoparticles (RESV-NPs), formulated from poly (lactic-co-glycolic) acid and iron oxide, enhanced the stability of RESV by 18-fold and served as photoacoustic tomography (PAT) contrast for MSCs. Read More

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http://dx.doi.org/10.1007/s13346-019-00621-6DOI Listing
June 2019
4 Reads

Liquid Crystalline Nanocolloids for the Storage of Electro-Optic Responsive Images.

ACS Appl Mater Interfaces 2019 Feb 15;11(8):8612-8624. Epub 2019 Feb 15.

Department of Chemistry , Tsinghua University , Beijing 100084 , China.

Liquid crystalline nanocolloids (LCNCs), which are nanostructured composites comprising nanoparticles (NPs) and a liquid crystal (LC) host, have attracted a great deal of attention because of their promising new fundamental physical behaviors and functional properties. Yet, it still remains a big challenge to pattern LCNCs into mesoscale-ordered structures due to the limited NP loading in the LC host. Here, we demonstrate LCNCs in the nematic phase with a high NP loading (∼42 wt %) by in situ co-functionalizing the NP with alkyl and mesogenic ligands. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b22636
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http://dx.doi.org/10.1021/acsami.8b22636DOI Listing
February 2019
26 Reads

Physiological and transcriptomic analyses reveal CuO nanoparticle inhibition of anabolic and catabolic activities of sulfate-reducing bacterium.

Environ Int 2019 04 30;125:65-74. Epub 2019 Jan 30.

Advanced Water Management Centre, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia. Electronic address:

The widespread use of CuO nanoparticles (NPs) results in their continuous release into the environment, which could pose risks to public health and to microbial ecosystems. Following consumption, NPs will initially enter into sewer systems and interact with and potentially influence sewer microbial communities. An understanding of the response of microbes in sewers, particularly sulfate-reducing bacteria (SRB), to the CuO NPs induced stress is important as hydrogen sulfide produced by SRB can cause sewer corrosion and odour emissions. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.058DOI Listing
April 2019
5 Reads

Surface Coverage-Regulated Cellular Interaction of Ultrasmall Luminescent Gold Nanoparticles.

ACS Nano 2019 02 4;13(2):1893-1899. Epub 2019 Feb 4.

Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510640 , China.

Investigations for accurately controlling the interaction between functional nanoparticles (NPs) and living cells set a long-thought benefit in nanomedicine and disease diagnostics. Here, we reveal a surface coverage-dependent cellular interaction by comparing the membrane binding and uptake of three ultrasmall luminescent gold NPs (AuNPs) with different surface coverages. Lower surface coverage leads to fast cellular interaction and strong membrane binding but low cellular uptake, whereas high surface coverage induces slow cellular interaction and low membrane binding but major cellular uptake. Read More

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http://dx.doi.org/10.1021/acsnano.8b08103DOI Listing
February 2019
2 Reads

Advances in Management of Psychosis in Neurodegenerative Diseases.

Curr Treat Options Neurol 2019 Jan 23;21(1). Epub 2019 Jan 23.

Department of Psychiatry, Yale School of Medicine, 300 George St., Suite 901, New Haven, CT, 06511, USA.

Purpose Of The Review: Psychosis is broadly defined as a disengagement from reality. It describes syndromes that impair both thought content and thought process. Psychosis negatively impacts an individual's quality of life, in addition to the families caring for them. Read More

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http://dx.doi.org/10.1007/s11940-019-0545-6DOI Listing
January 2019
25 Reads

Impact of Surface-Engineered ZnO Nanoparticles on Protein Corona Configuration and Their Interactions With Biological System.

J Pharm Sci 2019 05 5;108(5):1872-1889. Epub 2019 Jan 5.

Biochemistry Laboratory, Animal Facility, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address:

In biological system, the interaction between nanoparticles (NPs) and serum biomolecules results in the formation of a dynamic corona of different affinities. The formed corona enriched with opsonin protein is recognized by macrophages and immune effector cells, resulting in rapid clearance with induced toxicity. Hence, to reduce corona genesis, surface-engineered ZnO (c-ZnO) NPs were in situ synthesized using a polyacrylamide-grafted guar gum (PAm-g-GG) polymer that provided surface neutrality to the NPs. Read More

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http://dx.doi.org/10.1016/j.xphs.2018.12.021DOI Listing
May 2019
14 Reads
2.590 Impact Factor

Enhanced generation of reactive oxygen species and photocatalytic activity by Pt-based metallic nanostructures: the composition matters.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2019 30;37(1):1-13. Epub 2018 Dec 30.

a Key Laboratory for Micro-Nano Energy Storage and Conversion Materials of Henan Province , Institute of Surface Micro and Nano Materials; College of Advance Materials and Energy, Xuchang University , Xuchang , Henan , China.

The modification of semiconductor nanostructures with metallic nanocomponents can promote the separation of electron/hole from photoexited semiconductors by forming heterojunctions, thus exhibit enhanced photocatalytic activities and potential applications. In this study, Pt-based NPs, including Pt, PtCu, and PtCuCo are employed as model co-catalysts to comparatively study their capability to enhance the photocatalytic activity of TiO nanosheets. It was found that each of Pt, PtCu, and PtCuCo can greatly enhance the photocatalytic activity of TiO toward degradation of organic dyes. Read More

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http://dx.doi.org/10.1080/10590501.2018.1555317DOI Listing
February 2020
6 Reads

Controlled Synthesis of CuSe Nanoparticles as Near-Infrared Photothermal Agents and Irradiation Wavelength Dependence of Their Photothermal Conversion Efficiency.

Langmuir 2018 11 7;34(46):13905-13909. Epub 2018 Nov 7.

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics , South China Normal University , Guangzhou 510631 , China.

The ability to manipulate the near-infrared (NIR) localized surface plasmon resonance absorbance of copper chalcogenide materials is of utmost importance for applications such as photothermal therapy (PTT). In this work, we manipulate the NIR absorbance of copper selenide (CuSe) nanoparticles (NPs) by precisely controlling their size and composition. We also introduce a facile method for transferring ultrasmall hydrophobic CuSe NPs into aqueous solution. Read More

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http://dx.doi.org/10.1021/acs.langmuir.8b02133DOI Listing
November 2018
4 Reads