257 results match your criteria Adv Funct Mater[Journal]


Polydopamine encapsulation of fluorescent nanodiamonds for biomedical applications.

Adv Funct Mater 2018 Aug 20;28(33). Epub 2018 Jun 20.

Laboratory of Single Molecule Biophysics, NHLBI, NIH, Bethesda, MD 20892, USA.

Fluorescent nanodiamonds (FNDs) are promising bio-imaging probes compared with other fluorescent nanomaterials such as quantum dots, dye-doped nanoparticles, and metallic nanoclusters, due to their remarkable optical properties and excellent biocompatibility. Nevertheless, they are prone to aggregation in physiological salt solutions, and modifying their surface to conjugate biologically active agents remains challenging. Here, inspired by the adhesive protein of marine mussels, we demonstrate encapsulation of FNDs within a polydopamine (PDA) shell. Read More

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http://doi.wiley.com/10.1002/adfm.201801252
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http://dx.doi.org/10.1002/adfm.201801252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342502PMC
August 2018
4 Reads

Integration of stiff graphene and tough silk for the design and fabrication of versatile electronic materials.

Adv Funct Mater 2018 Feb 19;28(9). Epub 2017 Dec 19.

Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

The production of structural and functional materials with enhanced mechanical properties through the integration of soft and hard components is a common approach to Nature's materials design. However, directly mimicking these optimized design routes in the lab for practical applications remains challenging. For example, graphene and silk are two materials with complementary mechanical properties that feature ultrahigh stiffness and toughness, respectively. Read More

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http://dx.doi.org/10.1002/adfm.201705291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261468PMC
February 2018
2 Reads

Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme-Induced Local Retention Properties.

Adv Funct Mater 2018 Oct 14;28(44). Epub 2018 Sep 14.

Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, 413 East 69 Street, New York, NY 10021, USA,

An effective tumoral delivery system should show minimal removal by the reticuloendothelial system (RES), promote tumor uptake and penetration, and minimize on-site clearance. This study reports the design and synthesis of advanced self-assembling peptide nanofiber precursor (NFP) analogues. The peptidic nature of NFP offers the design flexibility for on-demand customization with imaging agents and surface charges while maintaining a set size, allowing for real-time monitoring of kinetic and dynamic tumoral delivery by multimodal fluorescence/positron emission tomography/computed tomography (fluo/PET/CT) imaging, for formulation optimization. Read More

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http://doi.wiley.com/10.1002/adfm.201803969
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http://dx.doi.org/10.1002/adfm.201803969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261308PMC
October 2018
13 Reads

Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles.

Adv Funct Mater 2018 Jan 8;28(1). Epub 2017 Nov 8.

Stanford Cardiovascular Institute, Stanford, CA, 94305, United States.

The last decade has seen impressive progress in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) that makes them ideal tools to repair injured hearts. To achieve an optimal outcome, advanced molecular imaging methods are essential to accurately track these transplanted cells in the heart. Herein, we demonstrate for the first time that a class of photoacoustic nanoparticles (PANPs) incorporating semiconducting polymers (SPs) as contrast agents can be used in the photoacoustic imaging (PAI) of transplanted hESC-CMs in living mouse hearts. Read More

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http://doi.wiley.com/10.1002/adfm.201704939
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http://dx.doi.org/10.1002/adfm.201704939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247950PMC
January 2018
13 Reads

Electrically Controlled Neurochemical Release from Dual-Layer Conducting Polymer Films for Precise Modulation of Neural Network Activity in Rat Barrel Cortex.

Adv Funct Mater 2018 Mar 11;28(12). Epub 2017 Dec 11.

Department of Bioengineering, University of Pittsburgh, 5057 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.

Implantable microelectrode arrays (MEAs) are important tools for investigating functional neural circuits and treating neurological diseases. Precise modulation of neural activity may be achieved by controlled delivery of neurochemicals directly from coatings on MEA electrode sites. In this study, a novel dual-layer conductive polymer/acid functionalized carbon nanotube (fCNT) microelectrode coating is developed to better facilitate the loading and controlled delivery of the neurochemical 6,7-dinitroquinoxaline-2,3-dione (DNQX). Read More

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http://dx.doi.org/10.1002/adfm.201703988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242295PMC
March 2018
17 Reads

Hybrid Paper-Plastic Microchip for Flexible and High-Performance Point-of-Care Diagnostics.

Adv Funct Mater 2018 Jun 25;28(26). Epub 2018 Apr 25.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's, Hospital, Harvard Medical School, Boston, MA 02115, USA, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

A low-cost and easy-to-fabricate microchip remains a key challenge for the development of true point-of-care (POC) diagnostics. Cellulose paper and plastic are thin, light, flexible, and abundant raw materials, which make them excellent substrates for mass production of POC devices. Herein, a hybrid paper-plastic microchip (PPMC) is developed, which can be used for both single and multiplexed detection of different targets, providing flexibility in the design and fabrication of the microchip. Read More

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http://doi.wiley.com/10.1002/adfm.201707161
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http://dx.doi.org/10.1002/adfm.201707161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223320PMC
June 2018
20 Reads

Thermogelling, ABC Triblock Copolymer Platform for Resorbable Hydrogels with Tunable, Degradation-Mediated Drug Release.

Adv Funct Mater 2017 Dec 27;27(47). Epub 2017 Oct 27.

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.

Clinical application of injectable, thermoresponsive hydrogels is hindered by lack of degradability and controlled drug release. To overcome these challenges, a family of thermoresponsive, ABC triblock polymer-based hydrogels has been engineered to degrade and release drug cargo through either oxidative or hydrolytic/enzymatic mechanisms dictated by the "A" block composition. Three ABC triblock copolymers are synthesized with varying "A" blocks, including oxidation-sensitive poly(propylene sulfide), slow hydrolytically/enzymatically degradable poly(ε-caprolactone), and fast hydrolytically/enzymatically degradable poly(D,L-lactide--glycolide), forming the respective formulations PPS--PDMA--PNIPAAM (PDN), PCL--PDMA--PNIPAAM (CDN), and PLGA--PDMA--PNIPAAM (LGDN). Read More

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http://dx.doi.org/10.1002/adfm.201704107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195316PMC
December 2017

Remote-Loaded Platelet Vesicles for Disease-Targeted Delivery of Therapeutics.

Adv Funct Mater 2018 May 19;28(22). Epub 2018 Apr 19.

Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

The recent emergence of biomimetic nanotechnology has facilitated the development of next-generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, we report on the remote loading of small molecule therapeutics into cholesterol-enriched platelet membrane-derived vesicles for disease-targeted delivery. Read More

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http://doi.wiley.com/10.1002/adfm.201801032
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http://dx.doi.org/10.1002/adfm.201801032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181445PMC
May 2018
16 Reads
11.800 Impact Factor

Nanoparticle-based fluoroionophore for analysis of potassium ion dynamics in 3D tissue models and .

Adv Funct Mater 2018 Feb 5;28(9). Epub 2018 Jan 5.

ABCRF, School of Biochemistry and Cell biology, University College Cork, Cork, Ireland.

The imaging of real-time fluxes of K ions in live cell with high dynamic range (5-150 mM) is of paramount importance for neuroscience and physiology of the gastrointestinal tract, kidney and other tissues. In particular, the research on high-performance deep-red fluorescent nanoparticle-based biosensors is highly anticipated. We found that BODIPY-based FI3 K-sensitive fluoroionophore encapsulated in cationic polymer RL100 nanoparticles displays unusually strong efficiency in staining of broad spectrum of cell models, such as primary neurons and intestinal organoids. Read More

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http://dx.doi.org/10.1002/adfm.201704598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157274PMC
February 2018
13 Reads

Intracellular Pathways Involved in Bone Regeneration Triggered by Recombinant Silk-silica Chimeras.

Adv Funct Mater 2018 Jul 4;28(27). Epub 2017 Sep 4.

Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.

Biomineralization at the organic-inorganic interface is critical to many biology material functions and . Recombinant silk-silica fusion peptides are organic-inorganic hybrid material systems that can be effectively used to study and control biologically-mediated mineralization due to the genetic basis of sequence control. However, to date, the mechanisms by which these functionalized silk-silica proteins trigger the differentiation of human mesenchymal stem cells (hMSCs) to osteoblasts remain unknown. Read More

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http://dx.doi.org/10.1002/adfm.201702570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101667PMC
July 2018
3 Reads

Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy.

Adv Funct Mater 2018 Apr 15;28(16). Epub 2018 Feb 15.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

The ability to produce nanotherapeutics at large-scale with high drug loading efficiency, high drug loading capacity, high stability, and high potency is critical for clinical translation. However, many nanoparticle-based therapeutics under investigation suffer from complicated synthesis, poor reproducibility, low stability, and high cost. In this work, a simple method for preparing multifunctional nanoparticles is utilized that act as both a contrast agent for magnetic resonance imaging and a photosensitizer for photodynamic therapy for the treatment of cancer. Read More

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http://dx.doi.org/10.1002/adfm.201707030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997278PMC
April 2018
7 Reads

Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction.

Adv Funct Mater 2018 May;28(21):1800618

Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ London, UK.

An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is introduced. The auxetic design gives the patch a negative Poisson's ratio, providing it with the ability to conform to the demanding mechanics of the heart. The conductivity allows the patch to interface with electroresponsive tissues such as the heart. Read More

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http://dx.doi.org/10.1002/adfm.201800618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985945PMC
May 2018
14 Reads

A Materials Roadmap to Functional Neural Interface Design.

Adv Funct Mater 2018 Mar 19;28(12). Epub 2017 Jul 19.

Department of Bioengineering, Center for the Basis of Neural Cognition, McGowan Institute of Regenerative Medicine, NeuroTech Center, University of Pittsburgh Brain Institute, Center for Neuroscience at the University of Pittsburgh, University of Pittsburgh, 208 Center for Biotechnology, 300 Technology Dr., Pittsburgh, PA 15219, United States.

Advancement in neurotechnologies for electrophysiology, neurochemical sensing, neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain while enabling treatments, cures, and preventative measures for a variety of neurological disorders. The grand challenge in neural interface engineering is to seamlessly integrate the interface between neurobiology and engineered technology, to record from and modulate neurons over chronic timescales. However, the biological inflammatory response to implants, neural degeneration, and long-term material stability diminish the quality of interface overtime. Read More

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http://dx.doi.org/10.1002/adfm.201701269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963731PMC
March 2018
1 Read

Nanoformulation of Brain-Derived Neurotrophic Factor with Target Receptor-Triggered-Release in the Central Nervous System.

Adv Funct Mater 2018 Feb 7;28(6). Epub 2017 Dec 7.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7362, USA.

Brain-derived neurotrophic factor (BDNF) is identified as a potent neuroprotective and neuroregenerative agent for many neurological diseases. Regrettably, its delivery to the brain is hampered by poor serum stability and rapid brain clearance. Here, a novel nanoformulation is reported composed of a bio-compatible polymer, poly(ethylene glycol)--poly(L-glutamic acid) (PEG-PLE), that hosts the BDNF molecule in a nanoscale complex, termed here Nano-BDNF. Read More

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http://doi.wiley.com/10.1002/adfm.201703982
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http://dx.doi.org/10.1002/adfm.201703982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958903PMC
February 2018
3 Reads

Functionally Graded, Bone- and Tendon-Like Polyurethane for Rotator Cuff Repair.

Adv Funct Mater 2018 May 30;28(20). Epub 2018 Mar 30.

Department of Orthopaedic Surgery Stanford University 300 Pasteur Drive, Stanford, CA 94305, USA.

Critical considerations in engineering biomaterials for rotator cuff repair include bone-tendon-like mechanical properties to support physiological loading and biophysicochemical attributes that stabilize the repair site over the long-term. In this study, UV-crosslinkable polyurethane based on quadrol (Q), hexamethylene diisocyante (H), and methacrylic anhydride (M; QHM polymers), which are free of solvent, catalyst, and photoinitiator, is developed. Mechanical characterization studies demonstrate that QHM polymers possesses phototunable bone- and tendon-like tensile and compressive properties (12-74 MPa tensile strength, 0. Read More

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http://dx.doi.org/10.1002/adfm.201707107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959293PMC
May 2018
6 Reads
11.800 Impact Factor

Targeted Delivery of CRISPR/Cas9-Mediated Cancer Gene Therapy via Liposome-Templated Hydrogel Nanoparticles.

Adv Funct Mater 2017 Dec 16;27(46). Epub 2017 Oct 16.

Department of Neurosurgery, Yale University, New Haven, CT 06510, USA.

Due to its simplicity, versatility, and high efficiency, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology has emerged as one of the most promising approaches for treatment of a variety of genetic diseases, including human cancers. However, further translation of CRISPR/Cas9 for cancer gene therapy requires development of safe approaches for efficient, highly specific delivery of both Cas9 and single guide RNA to tumors. Here, novel core-shell nanostructure, liposome-templated hydrogel nanoparticles (LHNPs) that are optimized for efficient codelivery of Cas9 protein and nucleic acids is reported. Read More

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http://dx.doi.org/10.1002/adfm.201703036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939593PMC
December 2017
3 Reads

Actively Targeted Deep Tissue Imaging and Photothermal-Chemo Therapy of Breast Cancer by Antibody-Functionalized Drug-Loaded X-Ray-Responsive Bismuth Sulfide@Mesoporous Silica Core-Shell Nanoparticles.

Adv Funct Mater 2018 Jan 11;28(5). Epub 2017 Dec 11.

Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK 73072, USA.

A theranostic platform combining synergistic therapy and real-time imaging attracts enormous attention but still faces great challenges, such as tedious modifications and lack of efficient accumulation in tumor. Here, a novel type of theranostic agent, bismuth sulfide@mesoporous silica (BiS@ mPS) core-shell nanoparticles (NPs), for targeted image-guided therapy of human epidermal growth factor receptor-2 (HER-2) positive breast cancer is developed. To generate such NPs, polyvinylpyrrolidone decorated rod-like BiS NPs are chemically encapsulated with a mesoporous silica (mPS) layer and loaded with an anticancer drug, doxorubicin. Read More

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http://dx.doi.org/10.1002/adfm.201704623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918278PMC
January 2018
8 Reads

Ice-Templated Protein Nanoridges Induce Bone Tissue Formation.

Adv Funct Mater 2017 Nov 5;27(44). Epub 2017 Oct 5.

Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK 73019-5300, USA.

Little is known about the role of biocompatible protein nanoridges in directing stem cell fate and tissue regeneration due to the difficulty in forming protein nanoridges. Here an ice-templating approach is proposed to produce semi-parallel pure silk protein nanoridges. The key to this approach is that water droplets formed in the protein films are frozen into ice crystals (removed later by sublimation), pushing the surrounding protein molecules to be assembled into nanoridges. Read More

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http://dx.doi.org/10.1002/adfm.201703726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898400PMC
November 2017
3 Reads

Fluorescent Nanomaterials for the Development of Latent Fingerprints in Forensic Sciences.

Adv Funct Mater 2017 Apr 28;27(14). Epub 2017 Feb 28.

School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.

This review presents an overview on the application of latent fingerprint development techniques in forensic sciences. At present, traditional developing methods such as powder dusting, cyanoacrylate fuming, chemical method, and small particle reagent method, have all been gradually compromised given their emerging drawbacks such as low contrast, sensitivity, and selectivity, as well as high toxicity. Recently, much attention has been paid to the use of fluorescent nanomaterials including quantum dots (QDs) and rare earth upconversion fluorescent nanomaterials (UCNMs) due to their unique optical and chemical properties. Read More

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http://dx.doi.org/10.1002/adfm.201606243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898818PMC
April 2017
1 Read

Multifunctional biomedical imaging in physiological and pathological conditions using a NIR-II probe.

Adv Funct Mater 2017 Jun 24;27(23). Epub 2017 Apr 24.

Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Rd, Lucas P095, Stanford, CA 94305-5484, USA.

Compared with imaging in the visible (400 - 650 nm) and near-infrared window I (NIR-I, 650 - 900 nm) regions, imaging in near-infrared window II (NIR-II, 1,000-1,700 nm) is a highly promising imaging modality with improved resolution and deeper tissue penetration. In this work, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), has been successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000. Then this novel NIR-II probe has been studied for multifunctional biological imaging. Read More

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http://dx.doi.org/10.1002/adfm.201700995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879786PMC
June 2017
4 Reads

Extended Solution Gate OFET-based Biosensor for Label-free Glial Fibrillary Acidic Protein Detection with Polyethylene Glycol-Containing Bioreceptor Layer.

Adv Funct Mater 2017 May 23;27(20). Epub 2017 Mar 23.

Department of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.

A novel organic field effect transistor (OFET) -based biosensor is described for label-free glial fibrillary acidic protein (GFAP) detection. We report the first use of an extended solution gate structure where the sensing area and the organic semiconductor are separated, and a reference electrode is not needed. Different molecular weight polyethylene glycols (PEGs) are mixed into the bio-receptor layer to help extend the Debye screening length. Read More

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http://dx.doi.org/10.1002/adfm.201606506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873605PMC
May 2017
8 Reads

Engineering Immunological Tolerance Using Quantum Dots to Tune the Density of Self-Antigen Display.

Adv Funct Mater 2017 Jun 3;27(22). Epub 2017 Apr 3.

Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, MD 20742, USA.

Treatments for autoimmunity - diseases where the immune system mistakenly attacks self-molecules - are not curative and leave patients immunocompromised. New studies aimed at more specific treatments reveal development of inflammation or tolerance is influenced by the form self-antigens are presented. Using a mouse model of multiple sclerosis (MS), we show for the first time that quantum dots (QDs) can be used to generate immunological tolerance by controlling the density of self-antigen on QDs. Read More

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http://dx.doi.org/10.1002/adfm.201700290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828250PMC
June 2017
3 Reads

Three-Dimensional Multiscale, Multistable, and Geometrically Diverse Microstructures with Tunable Vibrational Dynamics Assembled by Compressive Buckling.

Adv Funct Mater 2017 Apr 3;27(14). Epub 2017 Mar 3.

Department of Materials Science and Engineering, Biomedical Engineering, Neurological Surgery, Chemistry, Mechanical Engineering, Electrical Engineering and Computer Science, Simpson Querrey Institute and Feinberg Medical School, Center for Bio-Integrated Electronics, Northwestern University, Evanston, Illinois 60208 (USA).

Microelectromechanical systems remain an area of significant interest in fundamental and applied research due to their wide ranging applications. Most device designs, however, are largely two-dimensional and constrained to only a few simple geometries. Achieving tunable resonant frequencies or broad operational bandwidths requires complex components and/or fabrication processes. Read More

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http://dx.doi.org/10.1002/adfm.201605914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813837PMC
April 2017
16 Reads

Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy.

Adv Funct Mater 2017 Oct 21;27(39). Epub 2017 Aug 21.

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Near-infrared (NIR)-absorbing metal-based nanomaterials have shown tremendous potential for cancer therapy, given their facile and controllable synthesis, efficient photothermal conversion, capability of spatiotemporal-controlled drug delivery, and intrinsic imaging function. Tantalum (Ta) is among the most biocompatible metals and arouses negligible adverse biological responses in either oxidized or reduced forms, and thus Ta-derived nanomaterials represent promising candidates for biomedical applications. However, Ta-based nanomaterials by themselves have not been explored for NIR-mediated photothermal ablation therapy. Read More

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http://dx.doi.org/10.1002/adfm.201703261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743210PMC
October 2017
9 Reads

The influence of isomer purity on trap states and performance of organic thin-film transistors.

Adv Funct Mater 2017 Jan 14;3(1). Epub 2016 Dec 14.

Department of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.

Organic field-effect transistor (OFET) performance is dictated by its composition and geometry, as well as the quality of the organic semiconductor (OSC) film, which strongly depends on purity and microstructure. When present, impurities and defects give rise to trap states in the bandgap of the OSC, lowering device performance. Here, 2,8-difluoro-5,11-bis(triethylsilylethynyl)-anthradithiophene is used as a model system to study the mechanism responsible for performance degradation in OFETs due to isomer coexistence. Read More

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http://dx.doi.org/10.1002/aelm.201600294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721359PMC
January 2017
3 Reads

Electrically Oscillating Plasmonic Nanoparticles for Enhanced DNA Vaccination against Hepatitis C Virus.

Adv Funct Mater 2017 Feb 14;27(5). Epub 2016 Dec 14.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

The promise of DNA vaccines is far-reaching. However, the development of potent immunization methods remains a key challenge for its use in clinical applications. Here, an approach for in vivo DNA vaccination by electrically activated plasmonic Au nanoparticles is reported. Read More

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http://dx.doi.org/10.1002/adfm.201604139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701658PMC
February 2017
2 Reads

Ultrafast Near-Infrared Light-triggered Intracellular Uncaging to Probe Cell Signaling.

Adv Funct Mater 2017 Mar 1;27(11). Epub 2017 Feb 1.

Department of Mechanical Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States.

The possibility of regulating cell signaling with high spatial and temporal resolution within individual cells and complex cellular networks has important implications in biomedicine. In this report, we demonstrate a general strategy that uses near-infrared tissue-penetrating laser pulses to uncage biomolecules from plasmonic gold-coated liposomes, i.e. Read More

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http://dx.doi.org/10.1002/adfm.201605778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697715PMC
March 2017
3 Reads

Renal-Clearable PEGylated Porphyrin Nanoparticles for Image-guided Photodynamic Cancer Therapy.

Adv Funct Mater 2017 Sep 26;27(34). Epub 2017 Jul 26.

Departments of Radiology, University of Wisconsin-Madison, Wisconsin 53705, United States.

Noninvasive dynamic positron emission tomography (PET) imaging was used to investigate the balance between renal clearance and tumor uptake behaviors of polyethylene glycol (PEG)-modified porphyrin nanoparticles (TCPP-PEG) with various molecular weights. TCPP-PEG nanoparticles with clearance behavior would be a good candidate for PET image-guided photodynamic therapy. Read More

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http://dx.doi.org/10.1002/adfm.201702928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687274PMC
September 2017
3 Reads

MUC1 Aptamer Targeted SERS Nanoprobes.

Adv Funct Mater 2017 Aug 6;27(32). Epub 2017 Jul 6.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

Recently, surface-enhanced Raman scattering (SERS) nanoprobes (NPs) have shown promise in the field of cancer imaging due to their unparalleled signal specificity and high sensitivity. Here we report the development of a DNA aptamer targeted SERS NP. Recently, aptamers are being investigated as a viable alternative to more traditional antibody targeting due to their low immunogenicity and low cost of production. Read More

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http://dx.doi.org/10.1002/adfm.201606632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685177PMC

"Tissue Papers" from Organ-Specific Decellularized Extracellular Matrices.

Adv Funct Mater 2017 Sep 7;27(3). Epub 2017 Aug 7.

Department of Materials Science and Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL 60208, USA. Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL 60611, USA. Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL 60208, USA. Divsion of Organ Transplantation, Comprehensive Transplant Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Using an innovative, tissue-independent approach to decellularized tissue processing and biomaterial fabrication, the development of a series of "tissue papers" derived from native porcine tissues/organs (heart, kidney, liver, muscle), native bovine tissue/organ (ovary and uterus), and purified bovine Achilles tendon collagen as a control from decellularized extracellular matrix particle ink suspensions cast into molds is described. Each tissue paper type has distinct microstructural characteristics as well as physical and mechanical properties, is capable of absorbing up to 300% of its own weight in liquid, and remains mechanically robust ( = 1-18 MPa) when hydrated; permitting it to be cut, rolled, folded, and sutured, as needed. In vitro characterization with human mesenchymal stem cells reveals that all tissue paper types support cell adhesion, viability, and proliferation over four weeks. Read More

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http://dx.doi.org/10.1002/adfm.201700992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665058PMC
September 2017
10 Reads

Acoustic Separation of Nanoparticles in Continuous Flow.

Adv Funct Mater 2017 Apr 3;27(14). Epub 2017 Mar 3.

Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.

The separation of nanoscale particles based on their differences in size is an essential technique to the nanoscience and nanotechnology community. Here, nanoparticles are successfully separated in a continuous flow by using tilted-angle standing surface acoustic waves. The acoustic field deflects nanoparticles based on volume, and the fractionation of nanoparticles is optimized by tuning the cutoff parameters. Read More

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http://dx.doi.org/10.1002/adfm.201606039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668689PMC
April 2017
3 Reads

Multifunctional Photonics Nanoparticles for Crossing the Blood-Brain Barrier and Effecting Optically Trackable Brain Theranostics.

Adv Funct Mater 2016 Oct 5;26(39):7057-7066. Epub 2016 Sep 5.

Center for Theragnosis and Center for Neuro-Medicine, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea.

Theranostic photonic nanoparticles (TPNs) that cross the blood-brain barrier (BBB) and efficiently deliver a therapeutic agent to treat brain diseases, simultaneously providing optical tracking of drug delivery and release, are introduced. These TPNs are constructed by physical encapsulation of visible and/or near-infrared photonic molecules, in an ultrasmall micellar structure (<15 nm). Phytochemical curcumin is employed as a therapeutic as well as visible-emitting photonic component. Read More

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http://dx.doi.org/10.1002/adfm.201602808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658140PMC
October 2016
48 Reads
2 Citations
11.805 Impact Factor

Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells.

Adv Funct Mater 2017 Aug 30;27(31). Epub 2017 May 30.

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892 USA.

Multidrug resistance (MDR) resulting from overexpression of P-glycoprotein (Pgp) transporters increases the drug efflux and thereby limits the chemotherapeutic efficacy. It is desirable to administer both an gene silencer and a chemotherapeutic agent in a sequential way to generate a synergistic therapeutic effect in multidrug-resistant cancer cells. Herein, we rationally designed an anti- molecular beacon (MB)-based micelle (a-MBM) nanosystem, which is composed of a diacyllipid core densely packed with an MB corona. Read More

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http://dx.doi.org/10.1002/adfm.201701027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646829PMC
August 2017
16 Reads

Designing Thin, Ultrastretchable Electronics with Stacked Circuits and Elastomeric Encapsulation Materials.

Adv Funct Mater 2017 Jan 19;27(4). Epub 2016 Dec 19.

Department of Mechanical Engineering, Civil and Environmental Engineering and Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

Many recently developed soft, skin-like electronics with high performance circuits and low modulus encapsulation materials can accommodate large bending, stretching, and twisting deformations. Their compliant mechanics also allows for intimate, nonintrusive integration to the curvilinear surfaces of soft biological tissues. By introducing a stacked circuit construct, the functional density of these systems can be greatly improved, yet their desirable mechanics may be compromised due to the increased overall thickness. Read More

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http://dx.doi.org/10.1002/adfm.201604545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642935PMC
January 2017
11 Reads

Biocompatible D-A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy.

Adv Funct Mater 2017 Apr 15;27(13). Epub 2017 Feb 15.

Center of Super-Diamond and Advanced Films (COSDAF), Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong S. A. R. 999077, P. R. China.

The development of nanotheranostic agents that integrate diagnosis and therapy for effective personalized precision medicine has obtained tremendous attention in the past few decades. In this report, biocompatible electron donor-acceptor conjugated semiconducting polymer nanoparticles (PPor-PEG NPs) with light-harvesting unit is prepared and developed for highly effective photoacoustic imaging guided photothermal therapy. To the best of our knowledge, it is the first time that the concept of light-harvesting unit is exploited for enhancing the photoacoustic signal and photothermal energy conversion in polymer-based theranostic agent. Read More

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http://dx.doi.org/10.1002/adfm.201605094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642295PMC
April 2017
47 Reads

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping.

Adv Funct Mater 2017 Oct 14;27(39). Epub 2017 Aug 14.

State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.

Unlocking the secrets of the brain is a task fraught with complexity and challenge - not least due to the intricacy of the circuits involved. With advancements in the scale and precision of scientific technologies, we are increasingly equipped to explore how these components interact to produce a vast range of outputs that constitute function and disease. Here, an insight is offered into key areas in which the marriage of neuroscience and nanotechnology has revolutionized the industry. Read More

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http://dx.doi.org/10.1002/adfm.201700489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404766PMC
October 2017

Chemical Sensing Systems that Utilize Soft Electronics on Thin Elastomeric Substrates with Open Cellular Designs.

Adv Funct Mater 2017 Mar 9;9(3). Epub 2017 Jan 9.

Center for Bio-Integrated Electronics, Departments of Materials Science and Engineering, Biomedical Engineering, Chemistry Mechanical Engineering, Electrical Engineering and Computer Science, Neurological Surgery, Simpson Querrey Institute for Bio Nanotechnology, McCormick School of Engineering and Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA.

A collection of materials and device architectures are introduced for thin, stretchable arrays of ion sensors that mount on open cellular substrates to facilitate solution exchange for use in biointegrated electronics. The results include integration strategies and studies of fundamental characteristics in chemical sensing and mechanical response. The latter involves experimental measurements and theoretical simulations that establish important considerations in the design of low modulus, stretchable properties in cellular substrates, and in the realization of advanced capabilities in spatiotemporal mapping of chemicals' gradients. Read More

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http://dx.doi.org/10.1002/adfm.201605476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630126PMC
March 2017
57 Reads

Neuroendocrine Tumor-Targeted Upconversion Nanoparticle-Based Micelles for Simultaneous NIR-Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging.

Adv Funct Mater 2017 Feb 17;27(8). Epub 2017 Jan 17.

Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA. Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA. Department of Biomedical Engineering University of Wisconsin-Madison Madison, WI 53706, USA.

Although neuroendocrine tumors (NETs) are slow growing, they are frequently metastatic at the time of discovery and no longer amenable to curative surgery, emphasizing the need for the development of other treatments. In this study, multifunctional upconversion nanoparticle (UCNP)-based theranostic micelles are developed for NET-targeted and near-infrared (NIR)-controlled combination chemotherapy and photodynamic therapy (PDT), and bioimaging. The theranostic micelle is formed by individual UCNP functionalized with light-sensitive amphiphilic block copolymers poly(4,5-dimethoxy-2-nitrobenzyl methacrylate)-polyethylene glycol (PNBMA-PEG) and Rose Bengal (RB) photosensitizers. Read More

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http://dx.doi.org/10.1002/adfm.201604671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630134PMC
February 2017
15 Reads

Glycine -methylation in NGR-Tagged Nanocarriers Prevents Isoaspartate formation and Integrin Binding without Impairing CD13 Recognition and Tumor Homing.

Adv Funct Mater 2017 Sep;27(36)

IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy.

NGR (asparagine-glycine-arginine) is a tumor vasculature-homing peptide motif widely used for the functionalization of drugs, nanomaterials and imaging compounds for cancer treatment and diagnosis. Unfortunately, this motif has a strong propensity to undergo rapid deamidation. This reaction, which converts NGR into DGR, is associated with receptor switching from CD13 to integrins, with potentially important manufacturing, pharmacological and toxicological implications. Read More

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http://dx.doi.org/10.1002/adfm.201701245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624507PMC
September 2017
17 Reads

Engineered elastomer substrates for guided assembly of complex 3D mesostructures by spatially nonuniform compressive buckling.

Adv Funct Mater 2017 Jan 2;27(1). Epub 2016 Nov 2.

Department of Materials Science and Engineering, Chemistry, Mechanical Science and Engineering, Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (USA).

Approaches capable of creating three-dimensional (3D) mesostructures in advanced materials (device-grade semiconductors, electroactive polymers etc.) are of increasing interest in modern materials research. A versatile set of approaches exploits transformation of planar precursors into 3D architectures through the action of compressive forces associated with release of prestrain in a supporting elastomer substrate. Read More

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http://dx.doi.org/10.1002/adfm.201604281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621772PMC
January 2017
24 Reads

Advanced Functional Nanomaterials for Theranostics.

Adv Funct Mater 2017 Jan 7;27(2). Epub 2016 Nov 7.

Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, 14260, United States.

Nanoscale materials have been explored extensively as agents for therapeutic and diagnostic (i.e. theranostic) applications. Read More

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http://dx.doi.org/10.1002/adfm.201603524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560626PMC
January 2017
22 Reads

Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation.

Adv Funct Mater 2016 Aug 1;26(30):5427-5436. Epub 2016 Jul 1.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Hybrid usage of native tissue signals and the engineering control of collagen matrices show the ability to induce local infiltration and differentiation of hMSCs. Additionally, the solid cartilage microparticles inhibit bulk cell-mediated contraction of the composite. Read More

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http://doi.wiley.com/10.1002/adfm.201601877
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http://dx.doi.org/10.1002/adfm.201601877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560495PMC
August 2016
15 Reads

Miniaturized Battery-Free Wireless Systems for Wearable Pulse Oximetry.

Adv Funct Mater 2017 Jan 25;27(1). Epub 2016 Nov 25.

Department of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Development of unconventional technologies for wireless collection, storage and analysis of quantitative, clinically relevant information on physiological status is of growing interest. Soft, biocompatible systems are widely regarded as important because they facilitate mounting on external (e.g. Read More

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http://dx.doi.org/10.1002/adfm.201604373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545889PMC
January 2017
29 Reads

Tracking and Quantification of Magnetically Labeled Stem Cells using Magnetic Resonance Imaging.

Adv Funct Mater 2016 Jun 17;26(22):3899-3915. Epub 2016 Feb 17.

Bioimaging Research Center, Regenerative Bioscience Center, and Department of Physics University of Georgia, Athens, GA. 30602, USA.

Stem cell based therapies have critical impacts on treatments and cures of diseases such as neurodegenerative or cardiovascular disease. In vivo tracking of stem cells labeled with magnetic contrast agents is of particular interest and importance as it allows for monitoring of the cells' bio-distribution, viability, and physiological responses. Herein, recent advances are introduced in tracking and quantification of super-paramagnetic iron oxide (SPIO) nanoparticles-labeled cells with magnetic resonance imaging, a noninvasive approach that can longitudinally monitor transplanted cells. Read More

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http://dx.doi.org/10.1002/adfm.201504444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526633PMC
June 2016
26 Reads

Tunable Gas Sensing Gels by Cooperative Assembly.

Adv Funct Mater 2017 Jul;27(27)

UCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.

The cooperative assembly of biopolymers and small molecules can yield functional materials with precisely tunable properties. Here, the fabrication, characterization, and use of multicomponent hybrid gels as selective gas sensors are reported. The gels are composed of liquid crystal droplets self-assembled in the presence of ionic liquids, which further coassemble with biopolymers to form stable matrices. Read More

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http://dx.doi.org/10.1002/adfm.201700803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524183PMC
July 2017
12 Reads

A Cooperative Copper Metal-Organic Framework-Hydrogel System Improves Wound Healing in Diabetes.

Adv Funct Mater 2017 Jan 23;27(1). Epub 2016 Nov 23.

Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings that promote wound closure within a clinically relevant time frame. The use of copper ions has shown promise in wound healing applications possibly by promoting angiogenesis. However, reported treatments that use copper ions require multiple applications of copper salts or oxides to the wound bed, exposing the patient to potentially toxic levels of copper ions and resulting in variable outcomes. Read More

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http://dx.doi.org/10.1002/adfm.201604872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513192PMC
January 2017
51 Reads

Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted siRNA Delivery Vehicles.

Adv Funct Mater 2016 Nov 20;26(43):7824-7835. Epub 2016 Sep 20.

Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA. Simpson Querrey Institute (SQI) for BioNanotechnology, Northwestern University, 303 East Superior, Chicago, IL 60611, USA. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA. International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

Efficient systemic administration of therapeutic short interfering RNA (siRNA) is challenging. High-density lipoproteins (HDL) are natural RNA delivery vehicles. Specifically, native HDLs: 1) Load single-stranded RNA; 2) Are anionic, which requires charge reconciliation between the RNA and HDL, and 3) Actively target scavenger receptor type B-1 (SR-B1) to deliver RNA. Read More

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http://dx.doi.org/10.1002/adfm.201602600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510894PMC
November 2016

In Vivo Micro-CT Imaging of Human Mesenchymal Stem Cells Labeled with Gold-Poly-L-Lysine Nanocomplexes.

Adv Funct Mater 2017 Jan 28;27(3). Epub 2016 Nov 28.

Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, and Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, 217 Traylor, 720 Rutland Ave, Baltimore, Maryland 21205, USA.

Developing cell tracking is an important prerequisite for further development of cell-based therapy. So far, few computed tomography (CT) cell tracking studies have been described due to its notoriously low sensitivity and lack of efficient labeling protocols. We present a simple method to render human mesenchymal stem cells (hMSCs) sufficiently radiopaque by complexing 40 nm citrate-stabilized gold nanoparticles (AuNPs) with poly-L-lysine (PLL) and rhodamine B isothiocyanate (RITC). Read More

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http://dx.doi.org/10.1002/adfm.201604213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509226PMC
January 2017
22 Reads

Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach.

Adv Funct Mater 2016 Jun 27;26(21):3599-3611. Epub 2016 Apr 27.

Department of Chemical & Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, WI 53706, USA.

Many types of slippery liquid-infused porous surfaces (or 'SLIPS') can resist adhesion and colonization by microorganisms. These 'slippery' materials thus offer new approaches to prevent fouling on a range of commercial and industrial surfaces, including biomedical devices. However, while SLIPS can prevent fouling on surfaces to which they are applied, they can currently do little to prevent the proliferation of non-adherent (planktonic) organisms, stop them from colonizing other surfaces, or prevent them from engaging in other behaviors that could lead to infection and associated burdens. Read More

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http://dx.doi.org/10.1002/adfm.201505522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507623PMC
June 2016
34 Reads

Design of Multistimuli Responsive Hydrogels Using Integrated Modeling and Genetically Engineered Silk-Elastin-Like Proteins.

Adv Funct Mater 2016 Jun 15;26(23):4113-4123. Epub 2016 Apr 15.

Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.

Elastomeric, robust, and biocompatible hydrogels are rare, while the need for these types of biomaterials in biomedical-related uses remains high. Here, a new family of genetically engineered silk-elastin copolymers (SELPs) with encoded enzymatic crosslinking sites is developed for a new generation of stimuli-responsive yet robust hydrogels. Input into the designs is guided by simulation, and realized via genetic engineering strategies. Read More

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http://dx.doi.org/10.1002/adfm.201600236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488272PMC
June 2016
8 Reads