- Andrzej T Slominski,
- Michal A Zmijewski,
- Przemyslaw M Plonka,
- Jerzy P Szaflarski,
- Ralf Paus
Endocrinology 2018 Mar 12. Epub 2018 Mar 12.
Centre for Dermatology Research, University of Manchester, UK.
The skin, a self-regulating protective barrier organ, is empowered with sensory and computing capabilities to counteract the environmental stressors to maintain/restore disrupted cutaneous homeostasis. These complex functions are coordinated by a cutaneous neuro-endocrine system that also communicates in a bidirectional fashion with the central nervous, endocrine and immune systems, all acting in concert to control body homeostasis. While ultraviolet energy (UV) has played an important role in the origin and evolution of life, UV absorption by the skin not only triggers mechanisms that defend skin integrity and regulate global homeostasis, but also induces skin pathology (e. Read More