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    1 OF 1142

    Epinephrine Promotes COX-2-dependent Immune Suppression in Myeloid Cells and Cancer Tissues.
    Brain Behav Immun 2017 Feb 14. Epub 2017 Feb 14.
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA; The University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.. Electronic address:
    Activation of the sympathetic nervous system (e.g., due to stress) has been implicated in cancer progression and recurrence, but its cancer-promoting effects have been variable between different studies. Read More

    Jejunal metastasis of renal cell carcinoma.
    Rev Esp Enferm Dig 2017 Feb;109(2):147-148
    Aparato Digestivo, Complejo Hospitalario Universitario de Vigo.
    A 71-year-old female presented with melena and anemia. She had a past medical history of renal cell carcinoma diagnosed six years earlier and treated with left nephrectomy. Gastroscopy and colonoscopy showed no abnormalities. Read More

    The use of near-infrared fluorescence imaging in endocrine surgical procedures.
    J Surg Oncol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Endocrine Surgery, Cleveland Clinic, Cleveland, Ohio.
    Near-infrared fluorescence imaging in endocrine surgery is a new, yet highly investigated area. It involves indocyanine green use as well as parathyroid autofluorescence. Several groups have described their technique and reported on the observed utility. Read More

    A randomized comparison between costoclavicular and paracoracoid ultrasound-guided infraclavicular block for upper limb surgery.
    Can J Anaesth 2017 Feb 15. Epub 2017 Feb 15.
    Department of Anesthesia, Montreal General Hospital, McGill University, Montreal, QC, Canada.
    Background: This two-centre randomized trial compared costoclavicular and paracoracoid ultrasound-guided infraclavicular brachial plexus block in patients undergoing upper limb surgery. We hypothesized that both techniques would result in similar onset times and designed the study as an equivalence trial.

    Methods: Ninety patients undergoing upper limb surgery at or distal to the elbow were randomly allocated to receive a costoclavicular (n = 45) or paracoracoid (n = 45) ultrasound-guided infraclavicular brachial plexus block. Read More

    Accidental Ingestion of Nasal Packing Gauze during Endonasal Endoscopic Dacryocystorhinostomy under Local Anesthesia: A Case Report.
    Case Rep Ophthalmol 2017 Jan-Apr;8(1):31-34. Epub 2017 Jan 20.
    Department of Oculoplastic, Orbital and Lacrimal Surgery, Aichi Medical University Hospital, Aichi, Japan.
    Purpose: To report a case of accidental ingestion of a nasal packing gauze during endonasal endoscopic dacryocystorhinostomy (en-DCR) under local anesthesia.

    Case Report: A 66-year-old female patient underwent an en-DCR for a right acquired nasolacrimal duct obstruction. The surgery was performed in a supine position under local anesthesia. Read More

    [Trigemino-cardiac reflex in skull base surgery].
    Beijing Da Xue Xue Bao 2017 Feb;49(1):164-168
    Department of Neurosurgery, Peking University First Hospital, Beijing 100034, China.
    Objective: To explore the mechanism, clinical features, and prognosis of Trigemino-cardiac reflex (TCR) during skull base operations.

    Methods: A retrospective analysis was performed on 291 patients with skull base disease from Jan. 2009 to Oct. Read More

    Flank pain after minor trauma as the initial manifestation of malignant pheochromocytoma; a case report.
    J Nephropharmacol 2015 26;4(2):75-77. Epub 2015 Jun 26.
    Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
    Pheochromocytoma is a tumor which originates from chromaffin cells of the adrenal medulla or the sympathetic ganglia. This tumor secrets a high amount of catecholamine and metabolites, causing hypertension crisis with headache, tachycardia, sweating and flushing (classic triad of pheochromocytoma). However, in some cases the disease may cause atypical symptoms or may be asymptomatic. Read More

    Mixed corticomedullary adrenal carcinoma - case report: Comparison in features, treatment and prognosis with the other two reported cases.
    Int J Surg Case Rep 2017 Jan 31;31:254-261. Epub 2017 Jan 31.
    Alberoni Hospital, Damascus University Faculty of Medicine, P.O. Box: 60527, Damascus, Syria. Electronic address:
    Introduction: Adrenal corticomedullary adenoma was reviewed in many cases in PubMed Library, While the coincidence corticomedullary adrenal carcinoma in the same gland was just described in two cases in the medical literature. Our case is the third to be reported and was treated with surgery and adjuvant chemotherapy and followed for two years.

    Presentation Of Case: A 50-year-old man suffered from a mass effect in the left abdominal side. Read More

    European Society of Endocrine Surgeons (ESES) and European Network for the Study of Adrenal Tumours (ENSAT) recommendations for the surgical management of adrenocortical carcinoma.
    Br J Surg 2017 Mar;104(4):358-376
    Churchill Cancer Centre, Oxford University Hospitals Foundation Trust, Oxford, UK.
    Background: Radical surgery provides the best chance of cure for adrenocortical carcinoma (ACC), but perioperative surgical care for these patients is yet to be standardized.

    Methods: A working group appointed jointly by ENSAT and ESES used Delphi methodology to produce evidence-based recommendations for the perioperative surgical care of patients with ACC. Papers were retrieved from electronic databases. Read More

    A Sudden Change of Heart: A Case of Rapidly Reversed Stress Cardiomyopathy in a Critically Ill Patient.
    Cardiol Res 2016 Jun 24;7(3):119-121. Epub 2016 Jun 24.
    Department of Medicine and Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA.
    We report the case of a 79-year-old woman who presented to our hospital for elective removal of an infratentorial meningioma and suffered a periprocedural cardiac arrest. Shortly after uncomplicated induction of anesthesia prior to the surgery, the patient became hypotensive and bradycardic, culminating ultimately in a cardiac arrest with pulseless electrical activity. Return of spontaneous circulation occurred within 90 seconds of arrest, but the patient remained dependent on maximal doses of epinephrine and dopamine for hemodynamic support. Read More

    Current perioperative management of pheochromocytomas.
    Indian J Urol 2017 Jan-Mar;33(1):19-25
    Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
    Neuroendocrine tumors which have the potential to secrete catecholamines are either associated with sympathetic adrenal (pheochromocytoma) or nonadrenal (paraganglioma) tissue. Surgical removal of these tumors is always indicated to cure and prevent cardiovascular and other organ system complications associated with catecholamine excess. Some of these tumors have malignant potential as well. Read More

    Laparoscopic left and right adrenalectomy from an anterior approach - is there any difference? Outcomes in 176 consecutive patients.
    Wideochir Inne Tech Maloinwazyjne 2016 20;11(4):268-273. Epub 2016 Dec 20.
    Department of Miniinvasive Surgery and Endoscopy, F.D. Roosevelt Hospital, Banska Bystrica, Slovak Republic.
    Introduction: Traditionally, in open surgery, right adrenalectomy is considered technically more demanding than its left-sided counterpart. This belief is supposed to be attributable mainly to different anatomic characteristics of the adrenal veins. Whether this opinion is also correct for laparoscopic adrenalectomy remains elusive. Read More

    Corticomedullary mixed tumour resembling a small adrenal gland-involvement of cancer stem cells: case report.
    BMC Endocr Disord 2017 Feb 13;17(1). Epub 2017 Feb 13.
    Department of Endocrinology, Xinqiao Hospital, Third Military Medical University, Xinqiao Street No.183, Shapingba District, Chongqing, 400037, China.
    Background: Adrenal corticomedullary mixed tumours are very rare. Its mechanism is rarely reported. Here we report the first case of a corticomedullary mixed tumour resembling a "small adrenal gland" with distinct arrangement of the cortical and medullary layers. Read More

    Molecular markers of paragangliomas/pheochromocytomas.
    Oncotarget 2017 Feb 8. Epub 2017 Feb 8.
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
    Paragangliomas/pheochromocytomas comprise rare tumors that arise from the extra-adrenal paraganglia, with an incidence of about 2 to 8 per million people each year. Approximately 40% of cases are due to genetic mutations in at least one out of more than 30 causative genes. About 25-30% of pheochromocytomas/paragangliomas develop under the conditions of a hereditary tumor syndrome a third of which are caused by mutations in the VHL gene. Read More

    Appearance of a thymic mass after treatment of Cushing's syndrome.
    Asian Cardiovasc Thorac Ann 2017 Feb 19;25(2):150-153. Epub 2016 Dec 19.
    1 Internal Medicine Unit, University Hospital of Sassari, Sassari, Italy.
    A 23-year-old woman was referred to our center with hirsutism, acne, weight gain, weakness, and irregular menses. Laboratory tests revealed increased levels of cortisol and sex hormones, and reduced adrenocorticotropic hormone levels. The patient underwent a right adrenalectomy. Read More

    Shock induced endotheliopathy (SHINE) in acute critical illness - a unifying pathophysiologic mechanism.
    Crit Care 2017 Feb 9;21(1):25. Epub 2017 Feb 9.
    Capital Region Blood Bank, Rigshospitalet Section for Transfusion Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej, 9DK-2100, Copenhagen, Denmark.
    One quarter of patients suffering from acute critical illness such as severe trauma, sepsis, myocardial infarction (MI) or post cardiac arrest syndrome (PCAS) develop severe hemostatic aberrations and coagulopathy, which are associated with excess mortality. Despite the different types of injurious "hit", acutely critically ill patients share several phenotypic features that may be driven by the shock. This response, mounted by the body to various life-threatening conditions, is relatively homogenous and most likely evolutionarily adapted. Read More

    [Comparison of the effects of 0.1% bromfenac sodium eye drops and corticosteroids after small incision lenticule extraction].
    Zhonghua Yan Ke Za Zhi 2017 Jan;53(1):18-22
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    Objective: To study the safety, efficacy and tolerability of the usage of 0.1% bromfenac sodium eye drops in small incision lenticule extraction (SMILE). Methods: Prospective case control study. Read More

    Preoperative β-blockade and hypertension in the first hour of functional endoscopic sinus surgery.
    Laryngoscope 2017 Feb 3. Epub 2017 Feb 3.
    Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan, U.S.A.
    Objectives/hypothesis: Local anesthetic with epinephrine is commonly injected into the nasal mucosa during functional endoscopic sinus surgery (FESS). Systemic absorption of epinephrine following local injection may occur, resulting in a mild sympathetic response. This study seeks to determine whether an exaggerated sympathetic response to epinephrine is demonstrated in patients undergoing FESS treated preoperatively with established pharmacologic beta (β) adrenoceptor blockade. Read More

    Buffered 1% Lidocaine With Epinephrine Is as Effective as Non-Buffered 2% Lidocaine With Epinephrine for Mandibular Nerve Block.
    J Oral Maxillofac Surg 2017 Jan 5. Epub 2017 Jan 5.
    Dalton L. McMichael Distinguished Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC. Electronic address:
    Purpose: To assess outcomes for pulpal anesthesia and pain on injection for buffered 1% lidocaine with 1:100,000 epinephrine (EPI) versus non-buffered 2% lidocaine with 1:100,000 EPI.

    Patients And Methods: In a randomized cross-over trial approved by the institutional review board, buffered 1% lidocaine with 1:100,000 EPI was compared with non-buffered 2% lidocaine with 1:100,000 EPI. After mandibular nerve block with buffered lidocaine 40 mg or non-buffered lidocaine 80 mg, patients reported responses at the mandibular first molar and canine after cold and electrical pulp testing (EPT). Read More

    Chylous ascites after resection of giant adrenocortical carcinoma.
    Gland Surg 2016 Dec;5(6):639-643
    Pathology Department, Antalya Training and Research Hospital, Antalya, Turkey.
    Postoperative chylous ascites (PCA) is a rare clinical state that occurs during abdominal surgery. Despite its rarity, the need to diagnose and treat PCA is increasing in importance with the increased number of wide resections and lymph node dissections being performed and the serious consequences of treatment. Here we describe the PCA complications we observed after resection for treating a case of giant adrenocortical carcinoma and we have the brief review of the PCA complication. Read More

    Deferring surgical treatment of ambiguous genitalia into adolescence in girls with 21-hydroxylase deficiency: a feasibility study.
    Int J Pediatr Endocrinol 2017 28;2017. Epub 2017 Jan 28.
    0000 0001 2155 0800grid.5216.0First Department of Obstetrics and Gynaecology, University of Athens, Alexandra Hospital, Athens, Greece.
    Background: Genital surgery in Disorders of Sex Development (DSD) has been an area of debate over the past 20 years. Emerging scientific evidence in the late 1990s defied the then routine practice to surgically align genitalia to the sex of rearing, as early as possible. However, despite multitude of data showing detrimental effects to genital sensation and sexuality, few patients born with ambiguous genitalia have remained unoperated into adolescence. Read More

    A Mobile Device App to Reduce Time to Drug Delivery and Medication Errors During Simulated Pediatric Cardiopulmonary Resuscitation: A Randomized Controlled Trial.
    J Med Internet Res 2017 Feb 1;19(2):e31. Epub 2017 Feb 1.
    Department of Pediatric Emergency Medicine, Geneva Children's Hospital, University Hospitals of Geneva, Geneva, Switzerland.
    Background: During pediatric cardiopulmonary resuscitation (CPR), vasoactive drug preparation for continuous infusion is both complex and time-consuming, placing children at higher risk than adults for medication errors. Following an evidence-based ergonomic-driven approach, we developed a mobile device app called Pediatric Accurate Medication in Emergency Situations (PedAMINES), intended to guide caregivers step-by-step from preparation to delivery of drugs requiring continuous infusion.

    Objective: The aim of our study was to determine whether the use of PedAMINES reduces drug preparation time (TDP) and time to delivery (TDD; primary outcome), as well as medication errors (secondary outcomes) when compared with conventional preparation methods. Read More

    Patient-reported postoperative pain, body image, and cosmetic satisfaction after transumbilical laparoendoscopic single-site adrenalectomy.
    Asian J Endosc Surg 2017 Feb 1. Epub 2017 Feb 1.
    Department of Urology, Oita University Faculty of Medicine, Yufu, Japan.
    Introduction: Laparoendoscopic single-site surgery is a recently innovated urologic surgical procedure. Transumbilical laparoendoscopic single-site adrenalectomy (LESS-A) is technically safe and feasible in patients with benign adrenal tumors. To improve patient counseling and informed consent, we evaluated patient-reported postoperative pain, body image, and cosmetic satisfaction after transumbilical LESS-A. Read More

    Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content.
    Prostate 2017 Feb 1. Epub 2017 Feb 1.
    Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
    Background: The effects of a steroidal antiandrogen (AA) and 5-alpha-reductase inhibitor (5ARI) on prostate tissue hormone content and metabolism are not fully elucidated. The objective of this study is to investigate the hormone content and metabolism of the prostate tissues of patients treated with AA or 5ARI using the ultra-sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.

    Methods: Thirty-nine patients with benign prostatic hyperplasia (BPH) undergoing transurethral surgery were included. Read More

    Clinical Benefits of Unilateral Adrenalectomy in Patients with Subclinical Hypercortisolism Due to Adrenal Incidentaloma: Results from a Single Center.
    High Blood Press Cardiovasc Prev 2017 Mar 31;24(1):69-75. Epub 2017 Jan 31.
    Department of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
    Introduction: This study was designed to evaluate the results of unilateral laparoscopic adrenalectomy in patients with subclinical hypercortisolism (SH) due to adrenal incidentaloma (AI) concerning the main cardiometabolic disorders.

    Methods: We have studied between January 2000 to December 2015, 645 patients with AI (283 males and 362 females; mean age 61.9 ± 10 years) and we found 70 patients with SH (27 males and 43 females; mean age 61. Read More

    [A Case of Long-Term Survival of Resected Pancreatic Metastasis from Colon Cancer].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2459-2461
    Dept. of Digestive Surgery, Hyogo Prefectural Nishinomiya Hospital.
    Pancreatic metastasis of colorectal cancer is uncommon and is often identified in later stages of cancer, thereby making resection more uncommon. We report a case oflong -term survival after resection of metachronous metastasis to the pancreas from primary sigmoid colon cancer. A 50-year-old female patient underwent a sigmoid colon resection and bilateral salpingo-oophorectomy for sigmoid colon cancer and metastatic ovarian cancer in 2007. Read More

    [A Case of Metastatic Colorectal Cancer with HER2 Overexpression/Amplification].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2307-2309
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.
    We report a case of panitumumab-resistant rectal cancer with HER2 gene amplification detected by CancerPlex®. A 51- year-old man was diagnosed with an obstructive rectal cancer having lung and adrenal metastases. He underwent the Hartmann 's operation, and KRAS mutations were not detected. Read More

    [A Case of GIST of the Stomach with Long-Term Survival after Multidisciplinary Treatment, Including Four Surgical Resections of Liver Metastases].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2237-2239
    Dept. of Surgery, National Hospital Organization Osaka National Hospital.
    The most frequent relapse site of gastrointestinal stromal tumors(GIST)is the liver. We encountered a patient with longterm survival treated with multidisciplinary treatment, including4 hepatectomies for liver metastases. The patient was a woman aged 69 years at the time of the first medical treatment. Read More

    [A Case of Recurrent Breast Cancer with Adrenal Metastasis Resected Using Laparoscopic Surgery].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2035-2037
    Dept. of Surgery, National Hospital Organization Osaka National Hospital.
    We report a case of recurrent breast cancer with involvement of the right adrenal grand, which was resected using laparoscopic surgery. The patient was a 41-year-old woman who underwent duct-lobular segmentectomy for ductal carcinoma in situ. Histopathology showed microinvasion, and tested positive for ER and PR, but negative for HER2, so we applied radiation to the remaining breast and administered tamoxifen. Read More

    [Surgical Resection for Advanced Gastric Cancer with Portal Vein Tumor Embolus - Two Cases].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1948-1950
    Dept. of Surgery, Japan Community Health care Organization(JCHO)Osaka Hospital.
    Gastric cancer with portal tumor embolus is rare and there is no definite strategy for its surgical resection. We report 2 cases ofgastric cancer with portal vein tumor embolus treated using gastrectomy and thrombectomy. Case 1: The patient was a 56- year-old man. Read More

    [Resection of Hepatocellular Carcinoma with Synchronous Bilateral Adrenal Metastases].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1770-1772
    Dept. of Surgery, Toyonaka Municipal Hospital.
    A 59-year-old man was admitted to our hospital with liver dysfunction. Examinations revealed a huge liver tumor in the right hepatic lobe and a mass in each adrenal gland. The preoperative diagnosis was hepatocellular carcinoma(HCC)with synchronous bilateral adrenal metastases. Read More

    [A Case of Solitary Adrenal Metastasis from Rectal Cancer Treated by Adrenalectomy after Preoperative Chemotherapy].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1751-1753
    Dept. of Surgery, Hiratsuka Kyosai Hospital.
    Adrenal metastasis from colorectal cancer occurs in the presence of multiple synchronous metastases at other sites. We report a case of heterochronous solitary adrenal metastasis from rectal cancer. A 55-year-old man underwent anterior resection with D3 lymph node dissection for rectal cancer. Read More

    [Resection of Adrenal Metastasis after Chemotherapy and Radiation Therapy for a Patient with Stage IV B Hepatocellular Carcinoma].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1594-1596
    Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.
    In the treatment of hepatocellular carcinoma, atypical, off guideline multidisciplinary approaches are sometimes effective. A 70-year-old man was diagnosed with multiple hepatocellular carcinomas, multiple bone metastases, and a right adrenal metastasis. Sunitinib was started and the primary hepatic lesions and bone metastases disappeared. Read More

    Longitudinal changes in serum catecholamines, dopamine, serotonin, ACTH and cortisol in pregnant Spanish mares.
    Res Vet Sci 2017 Jan 21;115:29-33. Epub 2017 Jan 21.
    Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Cardenal Herrera University, Valencia, Spain. Electronic address:
    Systemic physiological changes required for placental and fetal development during pregnancy are associated with an activation of the sympathetic nervous system (SNS) and the hypothalamus-pituitary-adrenal axis (HPA) in women, but this fact has not been investigated in mares. Venous blood samples were taken monthly from 31 successful Spanish mares during the 11months of pregnancy. During the first 4months of pregnancy, adrenaline (AD), dopamine (DOPA) and ACTH increases, whereas 5-hydroxitryptamine (5-HT) decreased, and noradrenaline (NAD) and cortisol (CORT) did not change. Read More

    Pattern of extragastric recurrence and the role of abdominal computed tomography in surveillance after endoscopic resection of early gastric cancer: Korean experiences.
    Gastric Cancer 2017 Jan 27. Epub 2017 Jan 27.
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympicro 43-gil, Songpa-gu, Seoul, 05505, Korea.
    Background: Although extragastric recurrence after endoscopic resection of early gastric cancer is rare, it is important because of its potentially fatal outcomes. We investigated the patterns of extragastric recurrence after endoscopic resection and evaluated the role of abdominal computed tomography in surveillance.

    Methods: Between July 1994 and June 2014, 4915 patients underwent endoscopic resection of early gastric cancer. Read More

    Metachronous solitary metastasis to the thyroid gland from squamous cell carcinoma of the lung: a case report and literature review.
    Tumori 2017 Jan 23. Epub 2017 Jan 23.
     Medical Oncology Unit, Policlinico S. Orsola-Malpighi, Bologna - Italy.
    Introduction: Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination. Read More

    Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation stages in craniopharyngioma.
    Oncol Lett 2017 Jan 22;13(1):250-252. Epub 2016 Nov 22.
    Department of Neurosurgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China.
    Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation periods in craniopharyngioma cases were examined. Twenty patients who underwent tumor resection from January 2012 to January 2015 were included in the study. We monitored factors related to endocrine changes and hormone substitution treatment during pre- and post-operation periods. Read More

    The Society of Thoracic Surgeons Expert Consensus for the Resuscitation of Patients Who Arrest After Cardiac Surgery.
    • Authors:
    Ann Thorac Surg 2017 Jan 19. Epub 2017 Jan 19.
    Executive Summary: The Society of Thoracic Surgeons Task Force on Resuscitation After Cardiac Surgery provides this professional society perspective on resuscitation in patients who arrest after cardiac surgery. This document was created using a multimodal methodology for evidence generation and includes information from existing guidelines, from the International Liaison Committee on Resuscitation, from our own structured literature reviews on issues particular to cardiac surgery, and from an international survey on resuscitation hosted by CTSNet. In gathering evidence for this consensus paper, searches were conducted using the MEDLINE keywords "cardiac surgery," "resuscitation," "guideline," "thoracic surgery," "cardiac arrest," and "cardiac massage. Read More

    Higher Dose of Dexamethasone Does Not Further Reduce Facial Swelling After Orthognathic Surgery: A Randomized Controlled Trial Using 3-Dimensional Photogrammetry.
    Ann Plast Surg 2017 Jan 23. Epub 2017 Jan 23.
    From the *Craniofacial Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, †Saran Plastic Surgery Clinic, Incheon, Korea, ‡Wonjin Aesthetic Plastic Surgical Clinic, Seoul, Korea, §Craniofacial Research Center, and ∥Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
    Purpose: The objective of this prospective, double-blind, randomized clinical trial was to compare the effect of 2 dexamethasone dosages on reducing facial swelling after orthognathic surgery through 3-dimensional (3D) photogrammetry.

    Patients And Methods: Patients were classified into group 1 (control group) and group 2 (study group), depending on the administered dexamethasone dosage (5 and 15 mg, respectively). Three-dimensional images were recorded at 5 time points: preoperative (T0) and postoperative at 48 ± 6 hours (T1), 1 week (T2), 1 month (T3), and 6 months (T4). Read More

    Testicular enlargement in a pre-pubertal boy with adrenocortical tumour.
    Paediatr Int Child Health 2017 Jan 23:1-3. Epub 2017 Jan 23.
    a Faculty of Medicine, Department of Pediatrics , Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
    Adrenocortical tumours are rare in children. Virilisation caused by overproduction of adrenal androgens is the most common presentation. The testes of pre-pubertal boys with this tumour are usually small or of pre-pubertal size. Read More

    Assessment of the Aldosteronona resolution score as a predictive resolution score of hypertension after adrenalectomy for aldosteronoma in French patients.
    Langenbecks Arch Surg 2017 Jan 22. Epub 2017 Jan 22.
    Clinique de Chirurgie Digestive et Endocrinienne (CCDE), Institut des Maladies de l'Appareil Digestif (IMAD), CHU Hôtel-Dieu, 1 place Alexis Ricordeau, 44093, Nantes cedex 1, France.
    Purpose: Aldosteronoma Resolution Score (ARS) is a predictive score for cure of hypertension after adrenalectomy for hyperaldosteronism and has been validated in American patients. The aim of the study was to validate this score in a French population.

    Method: Data concerning patients operated from 2002 to 2015 in 7 French University Hospitals were retrospectively collected. Read More

    Aldosterone excess may inhibit insulin secretion: A comparative study on glucose metabolism pre- and post-adrenalectomy in patients with primary aldosteronism.
    Endocr J 2017 Jan 20. Epub 2017 Jan 20.
    Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama 222-0036, Japan.
    Conflicting data have been published on the effects of aldosterone excess on glucose metabolism. Specifically, there are limited data on whether adrenalectomy in patients with aldosterone-producing adenomas (APA) can improve glucose metabolism. In this study we evaluated changes in glucose metabolism, before and after surgery for APA. Read More

    Management of carotid body tumor in pediatric patients: A case report and review of the literature.
    Int J Pediatr Otorhinolaryngol 2017 Feb 20;93:47-52. Epub 2016 Dec 20.
    Department of Otorhinolaryngology, Head and Neck Surgery, B-A-Z County Hospital and University Teaching Hospital, Miskolc, Hungary. Electronic address:
    Carotid body tumors (CBTs) are rare types of extra-adrenal paragangliomas, which originate from the neuroendocrine cells of the adventitial layer of carotid bifurcation. An 8-year-old girl was admitted to our department with left-sided and pulsating neck swelling, which progressively grew over several months. The patient had no family history of CBTs. Read More

    Computed Tomography in the Management of Adrenal Tumors: Does Size Still Matter?
    J Comput Assist Tomogr 2017 Jan 20. Epub 2017 Jan 20.
    From the *Endocrine Surgery, Department of Surgery, and Departments of †Radiology and Radiological Sciences, ‡Oncology, and §Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
    Objective: We sought to evaluate computed tomography (CT) imaging as a predictor of adrenal tumor pathology.

    Methods: A retrospective review was conducted of patients who underwent unilateral adrenalectomy for an adrenal mass between January 2005 and July 2015. Tumors were classified as benign, indeterminate, or malignant based on preoperative CT findings. Read More

    J Appl Physiol (1985) 2017 Jan 19:jap.00975.2016. Epub 2017 Jan 19.
    Johns Hopkins University
    Obstructive sleep apnea is associated with type 2 diabetes. We have previously developed a mouse model of intermittent hypoxia (IH) mimicking oxyhemoglobin desaturations in patients with sleep apnea and have shown that IH increases fasting glucose, hepatic glucose output, and plasma catecholamines. We hypothesize that adrenal medulla modulates glucose responses to IH, and that such responses can be prevented by adrenal medullectomy. Read More

    A new model of multi-visceral and bone metastatic prostate cancer with perivascular niche targeting by a novel endothelial specific adenoviral vector.
    Oncotarget 2017 Jan 17. Epub 2017 Jan 17.
    Urology Division and Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.
    While modern therapies for metastatic prostate cancer (PCa) have improved survival they are associated with an increasingly prevalent entity, aggressive variant PCa (AVPCa), lacking androgen receptor (AR) expression, enriched for cancer stem cells (CSCs), and evidencing epithelial-mesenchymal plasticity with a varying extent of neuroendocrine transdifferentiation. Parallel work revealed that endothelial cells (ECs) create a perivascular CSC niche mediated by juxtacrine and membrane tethered signaling. There is increasing interest in pharmacological metastatic niche targeting, however, targeted access has been impossible. Read More

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