54,421 results match your criteria Adrenal Surgery


MDR1 inhibition increases sensitivity to doxorubicin and etoposide in adrenocortical cancer.

Endocr Relat Cancer 2019 Jan 1. Epub 2019 Jan 1.

L Hofland, Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

Chemotherapy for adrenocortical carcinoma (ACC) has limited efficacy and is accompanied by severe toxicity. This lack of effectiveness has been associated with high tumoral levels of the multidrug resistance (MDR) pump P-glycoprotein (P-gp), encoded by the MDR1 gene. In this study, effects of P-gp inhibition on sensitivity of ACC cells to cytotoxic drugs were evaluated. Read More

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http://dx.doi.org/10.1530/ERC-18-0500DOI Listing
January 2019

Surgery in oligometastatic NSCLC patients in the targeted therapy era.

Authors:
Qi Zhang Yi-Long Wu

Lung Cancer Manag 2016 Nov 5;5(3):141-153. Epub 2016 Sep 5.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510515, PR China.

More than 50% of NSCLC patients present with metastatic disease at first diagnosis, with a median survival of 8-11 months. However, selected patients with oligometastatic disease who receive appropriate local therapy for both the primary lesion and metastases enjoy long-term survival or are even cured. The new (eighth) edition of the tumor, node and metastasis classification of lung cancer suggests that patients with a single metastatic lesion in one distant organ should be placed into a new category, M1b, which will certainly lead to more applications of local therapy in such subpopulations. Read More

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https://www.futuremedicine.com/doi/10.2217/lmt-2016-0012
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http://dx.doi.org/10.2217/lmt-2016-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310314PMC
November 2016
1 Read

A local anesthesia without tourniquet for distal fibula hardware removal after open reduction and internal fixation: the safe use of epinephrine in the foot. A randomized clinical study.

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6 Suppl. 1):57-63

Intensive Unit Care, University of Pisa, Italy.

Hardware removal after surgical treatment fracture is one of the most common procedures in orthopaedic daily activity. A percentage from 14.5 to 21 of total removal involves the ankle joint. Read More

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January 2019

The triple variable index combines information generated over time from common monitoring variables to identify patients expressing distinct patterns of intraoperative physiology.

BMC Med Res Methodol 2019 Jan 14;19(1):17. Epub 2019 Jan 14.

Department of Anesthesiology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA, 15261, USA.

Background: Mean arterial pressure (MAP), bispectral index (BIS), and minimum alveolar concentration (MAC) represent valuable, yet dynamic intraoperative monitoring variables. They provide information related to poor outcomes when considered together, however their collective behavior across time has not been characterized.

Methods: We have developed the Triple Variable Index (TVI), a composite variable representing the sum of z-scores from MAP, BIS, and MAC values that occur together during surgery. Read More

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http://dx.doi.org/10.1186/s12874-019-0660-9DOI Listing
January 2019

[Effect of Transcutaneous Acupoint Electrical Stimulation on Propofol Usage in Closed-loop Anes- thesia Delivery System in Pediatric Cardiac Surgery].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 08;36(8):916-921

Objective To evaluate the effect of transcutaneous acupoint electrical stimulation (TEAS) on propofol usage in closed-loop anesthesia delivery system and pediatric hemodynamics. Methods Sixty children patients undergoing selective tonsillectomy and adenoidectomy surgeries were randomly allocated to the TEAS group (T) and the control group (C) , 30 in each group. Anesthesia maintenance in both groups was performed by propofol closed-loop anesthesia infusion system after induction of anesthesia. Read More

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Familial and Hereditary Forms of Primary Hyperparathyroidism.

Front Horm Res 2019 19;51:40-51. Epub 2018 Nov 19.

Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT. Read More

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https://www.karger.com/Article/FullText/491037
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http://dx.doi.org/10.1159/000491037DOI Listing
November 2018
2 Reads

Pheochromocytoma-related cardiomyopathy presenting as broken heart syndrome: Case report and literature review.

Int J Surg Case Rep 2019 Jan 9;55:7-10. Epub 2019 Jan 9.

Department of Surgery, Kendall Regional Medical Center, Miami, FL, United States.

Introduction: Pheochromocytoma are neuroendocrine tumors that arise from sympathetic chromaffin cells within the adrenal medulla. They principally secrete catecholamines, potentially causing life-threatening cardiovascular complications. A myriad of symptomatology and clinical findings are associated with pheochromocytoma, including a catecholamine-induced dilated cardiomyopathy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.12.003DOI Listing
January 2019

Catecholaminergic Polymorphic Ventricular Tachycardia: The Cardiac Arrest Where Epinephrine Is Contraindicated.

Pediatr Crit Care Med 2019 Jan 11. Epub 2019 Jan 11.

Green Lane Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand.

Objectives: To raise awareness among pediatric intensive care specialists of catecholaminergic polymorphic ventricular tachycardia; an uncommon cause of polymorphic ventricular tachycardia and ventricular fibrillation arrest in children and young adults where epinephrine (adrenaline), even when given according to international protocols, can be counter-productive and life-threatening. We review three cases of cardiac arrest in children, later proven to be catecholaminergic polymorphic ventricular tachycardia related, where delay in recognition of this condition resulted in significantly longer resuscitation efforts, more interventions, and a longer time to return of spontaneous circulation.

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001847DOI Listing
January 2019

A multicenter, randomized comparison between 2, 5, and 8 mg of perineural dexamethasone for ultrasound-guided infraclavicular block.

Reg Anesth Pain Med 2019 Jan;44(1):46-51

Department of Anesthesia, Montreal General Hospital, McGill University, Montreal, Quebec, Canada

Background And Objectives: This multicenter, randomized trial compared 2, 5, and 8 mg of perineural dexamethasone for ultrasound-guided infraclavicular brachial plexus block. Our research hypothesis was that all three doses of dexamethasone would result in equivalent durations of motor block (equivalence margin=3.0 hours). Read More

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http://dx.doi.org/10.1136/rapm-2018-000032DOI Listing
January 2019

Survival outcomes following adrenalectomy for isolated metastases to the adrenal gland.

Eur J Surg Oncol 2019 Jan 4. Epub 2019 Jan 4.

Department of General Surgery, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, G51 4TF, United Kingdom.

Background: Adrenal metastases can arise from different primary sites. Surgical resection of the adrenal gland in patients with isolated metastases may offer improved survival in many of these patients. However, the benefit of surgery in this heterogenous group is often disputed. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.006DOI Listing
January 2019

Inferior alveolar nerve block by intraosseous injection with Quicksleeper® at the retromolar area in mandibular third molar surgery.

J Dent Anesth Pain Med 2018 Dec 28;18(6):339-347. Epub 2018 Dec 28.

Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

Background: There are many techniques of inferior alveolar nerve block injection (IANBI); one among them is the computer-assisted intraosseous injection (CAIOI). Here we aim to evaluate the effectiveness of CAIOI with Quicksleeper® in mandibular third molar surgery.

Methods: This study is a clinical, single-blind, randomized, split-mouth, controlled trial including 25 patients (10 males and 15 females, mean age 21 years). Read More

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http://dx.doi.org/10.17245/jdapm.2018.18.6.339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323038PMC
December 2018

Recovery of the adrenal function after pituitary surgery in patients with Cushing Disease: persistent remission or recurrence?

Neuroendocrinology 2019 Jan 13. Epub 2019 Jan 13.


Background Cushing's disease (CD) represents the principal cause of endogenous hypercortisolism. The first-line therapy of CD is surgical removal of the ACTH secreting pituitary adenoma, which is generally followed by adrenal insufficiency (AI). Objective To analyse the recovery of the AI in patients with CD after pituitary surgery in relation with recurrence and persistent remission of CD. Read More

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http://dx.doi.org/10.1159/000496846DOI Listing
January 2019
1 Read

Serum ropivacaine levels after local infiltration analgesia during total knee arthroplasty with and without adductor canal block.

Reg Anesth Pain Med 2019 Jan 11. Epub 2019 Jan 11.

Department of Anesthesiology, University of Utah Hospital, Salt Lake City, Utah, USA.

Background And Objectives: A common analgesic technique for total knee arthroplasty (TKA) is to inject local anesthetic into the periarticular tissue during surgery, known as local infiltration analgesia (LIA). Since the solution used typically contains a large amount of local anesthetic, concerns arise about exceeding the maximum dosage when adding a peripheral nerve block. Little research exists that addresses serum ropivacaine concentrations following LIA combined with peripheral nerve block. Read More

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http://rapm.bmj.com/lookup/doi/10.1136/rapm-2018-100043
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http://dx.doi.org/10.1136/rapm-2018-100043DOI Listing
January 2019
2 Reads

Randomized comparison between interscalene and costoclavicular blocks for arthroscopic shoulder surgery.

Reg Anesth Pain Med 2019 Jan 11. Epub 2019 Jan 11.

Department of Anesthesia, McGill University, Montreal, Quebec, Canada.

Background: This randomized trial compared ultrasound-guided interscalene block (ISB) and costoclavicular brachial plexus block (CCB) for arthroscopic shoulder surgery. We hypothesized that CCB would provide equivalent analgesia to ISB 30 min after surgery without the risk of hemidiaphragmatic paralysis.

Methods: All 44 patients received an ultrasound-guided block of the intermediate cervical plexus. Read More

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http://dx.doi.org/10.1136/rapm-2018-100055DOI Listing
January 2019

Foot reconstruction with the superficial circumflex iliac artery perforator flap under local anesthesia: Two case reports.

Medicine (Baltimore) 2019 Jan;98(2):e13888

Division of Plastic and Reconstructive Surgery, National Nagasaki Medical Center, Japan.

Rationale: The superficial circumflex iliac artery perforator (SCIP) free flap is a popular method used in foot reconstruction. Although the SCIP flap has a relatively short pedicle and does not require intramuscular dissection, general anesthesia is largely preferred for SCIP flap reconstruction. We report 2 cases with the free SCIP flap for skin and soft tissue reconstruction of the foot under local anesthesia. Read More

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http://dx.doi.org/10.1097/MD.0000000000013888DOI Listing
January 2019
1 Read

Ga-DOTATOC PET/CT in the localization of metastatic extra-adrenal paraganglioma and pheochromocytoma compared with F-DOPA PET/CT.

Rev Esp Med Nucl Imagen Mol 2019 Jan 7. Epub 2019 Jan 7.

Department of Nuclear Medicine, Medical University Innsbruck, Innsbruck, Austria.

Objective: F-Fluoro-L-dihydroxyphenylalanine (F-DOPA) PET offers high sensitivity and specificity in the imaging of non-malignant extra-adrenal paraganglioma (PGL) and pheochromocytoma (PHEO) but lower sensitivity in metastatic disease. These tumours are of neuroendocrine origin and can be detected by Ga-DOTA-Tyr3-octreotide (Ga-DOTA-TOC) PET. Therefore, we compared Ga-DOTA-TOC and F-DOPA as radiolabels for PET/CT imaging for the diagnosis of metastatic extra-adrenal PGL and PHEO. Read More

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http://dx.doi.org/10.1016/j.remn.2018.09.004DOI Listing
January 2019

Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review.

Int J Womens Dermatol 2018 Dec 19;4(4):203-211. Epub 2018 Jun 19.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.

Female pattern hair loss (FPHL) is the most common form of alopecia in women. Affected women may experience psychological distress and impaired social functioning. Early diagnosis and initiation of treatment are desirable because treatments are more effective to avoid the progression of hair loss than stimulating regrowth. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322157PMC
December 2018

Suprasellar chordoid glioma: a report of two cases.

Arch Endocrinol Metab 2018 ;62(6):648-654

Instituto de Investigaciones Neurológicas "Dr. Raúl Carrea", FLENI, Pathology, Buenos Aires, Argentina.

Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. Read More

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http://dx.doi.org/10.20945/2359-3997000000092DOI Listing
January 2018
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Organ-sparing procedures in GU cancer: part 1-organ-sparing procedures in renal and adrenal tumors: a systematic review.

Int Urol Nephrol 2019 Jan 8. Epub 2019 Jan 8.

Department of Urology, Baylor College of Medicine and Michael E. De Bakey VA Medical Center, Houston, TX, USA.

Purpose: Organ-sparing surgery (OSS) for the kidney and adrenals has emerged as the need for preservation of function is paramount in patients with poor functional reserve. As reports increasingly showed that oncological outcomes were equivalent to radical excision, elective OSS became a viable alternative in patients with otherwise normal reserve. In this review, we summarize the current knowledge of OSS for adrenal and renal tumors. Read More

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http://dx.doi.org/10.1007/s11255-018-02070-5DOI Listing
January 2019

Epigenetic Alterations Associated With Early Prenatal Dexamethasone Treatment.

J Endocr Soc 2019 Jan 12;3(1):250-263. Epub 2018 Dec 12.

Department of Women's and Children's Health, Karolinska Institutet, Paediatric Endocrinology Unit (Q2:08), Karolinska University Hospital, Stockholm, Sweden.

Prenatal treatment with dexamethasone (DEX) reduces virilization in girls with congenital adrenal hyperplasia (CAH). It has potential short- and long-term risks and has been shown to affect cognitive functions. Here, we investigate whether epigenetic modification of DNA during early developmental stages may be a key mediating mechanism by which prenatal DEX treatment could result in poor outcomes in the offspring. Read More

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https://academic.oup.com/jes/article/3/1/250/5239844
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http://dx.doi.org/10.1210/js.2018-00377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320242PMC
January 2019
1 Read

Laparoscopic Excision of an Adrenal Ganglioneuroma Presented as an Incindentaloma of the Retro Peritoneum.

Curr Health Sci J 2018 Jan-Mar;44(1):71-75. Epub 2018 Feb 11.

3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Adrenal ganglioneuroma (GN) is a benign tumor of retro-peritoneum that is presented as an incidentaloma. GNs most commonly have been diagnosed by imaging examinations notably by CT scan. Differential diagnosis from other malignant adrenal tumors is often difficult. Read More

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http://dx.doi.org/10.12865/CHSJ.44.01.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295176PMC
February 2018
1 Read

Laparoscopic adrenalectomy for ganglioneuroma presenting as an adrenal incidentaloma.

J Minim Access Surg 2019 Jan 4. Epub 2019 Jan 4.

Max Institute of Minimal Access, Metabolic Bariatric Surgery, Max Healthcare Max Super Speciality Hospital, New Delhi, India.

Adrenal incidentaloma (AI) has now become a common finding in clinical practice with advances in abdominal imaging. The prevalence of AI as reported in the literature is 0.2%-3%. Read More

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http://dx.doi.org/10.4103/jmas.JMAS_228_18DOI Listing
January 2019
1 Read

Initial free cortisol dynamics following blunt multiple trauma and traumatic brain injury: A clinical study.

J Int Med Res 2019 Jan 7:300060518819603. Epub 2019 Jan 7.

1 Department of Trauma Surgery, Ludwig Maximilians University Munich, Munich, Germany.

Objective: To determine free and total cortisol serum concentrations in the first 24 h after trauma and to evaluate the influence of traumatic brain injury (TBI) on their dynamics.

Methods: This prospective cohort study enrolled patients who had experienced multiple trauma and were admitted to a level 1 trauma centre. The patients were divided in two groups based on the presence of TBI according to clinical and radiological findings. Read More

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http://dx.doi.org/10.1177/0300060518819603DOI Listing
January 2019

Effect of dexmedetomidine or propofol sedation on haemodynamic stability of patients after thoracic surgery.

Anaesthesiol Intensive Ther 2018 ;50(5):359-366

Department of Anaesthesiology and Intensive Therapy, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia, Katowice.

Background: Dexmedetomidine and propofol are commonly used sedative agents in non-invasive ventilation as they allow for easy arousal and are relatively well controllable. Moreover dexmedetomidine is associated with low risk of respiratory depression. However, both agents are associated with significant hemodynamic side effects. Read More

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https://journals.viamedica.pl/anaesthesiology_intensivethera
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http://dx.doi.org/10.5603/AIT.a2018.0046DOI Listing
January 2018
1 Read

Management of Adrenal Insufficiency Risk After Long-term Systemic Glucocorticoid Therapy in Duchenne Muscular Dystrophy: Clinical Practice Recommendations.

J Neuromuscul Dis 2019 Jan 2. Epub 2019 Jan 2.

Department of Pediatrics, Division of Endocrinology, University of Colorado School of Medicine, Aurora, Colorado, USA.

Long-term glucocorticoid therapy has improved outcomes in patients with Duchenne muscular dystrophy. However, the recommended glucocorticoid dosage suppresses the hypothalamic-pituitary-adrenal axis, leading to adrenal insufficiency that may develop during severe illness, trauma or surgery, and after discontinuation of glucocorticoid therapy. The purpose of this review is to highlight the risk of adrenal insufficiency in this patient population, and provide practical recommendations for management of adrenal insufficiency, glucocorticoid withdrawal, and adrenal function testing. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/JND-180346DOI Listing
January 2019
2 Reads

The Impact of Stress on Epidermal Barrier Function - An Evidence-Based Review.

Br J Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Department of Medicine, Division of Dermatology, University of Arizona - Tucson, AZ.

Introduction: The epidermal barrier functions to limit skin infection and inflammation by inhibiting irritant and immunogen invasion. Abundant evidence suggests that psychological stress stemming from crowding, isolation, nicotine smoking, insomnia, mental arithmetic tasks, physical pain, real life-stressors (examinations and marital strain), and lack of positive personality traits may impart both acute and chronic epidermal dysfunction.

Materials/methods: A review of PubMed and EMBASE databases was conducted to identify all English case-control, cross-sectional, and randomized control trials that report the effect of stress on epidermal barrier function. Read More

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http://doi.wiley.com/10.1111/bjd.17605
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http://dx.doi.org/10.1111/bjd.17605DOI Listing
January 2019
2 Reads

Gender and Cortisone: Clinical Practice and Transatlantic Exchange in the Medical Management of Intersex in the 1950s.

Authors:
Sandra Eder

Bull Hist Med 2018 ;92(4):604-633

This article complicates the history of the standardization of intersex case management developed at the Johns Hopkins Hospital in the 1950s by focusing on clinical practices and logics and the transatlantic circulation of knowledge. Using patient records and published studies, I follow the exchanges between pediatric endocrinologists Lawson Wilkins (Pediatric Endocrinology Clinic, Baltimore) and Andrea Prader (University Children's Hospital, Zürich) on cortisone treatment for children with congenital adrenal hyperplasia (CAH), on psychosexuality and gender role, on choosing and changing the sex of intersex children, and on genital surgery. I argue that a focus on the transatlantic exchanges between these two clinics illuminates a more complex genealogy of modern intersex case management. Read More

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http://dx.doi.org/10.1353/bhm.2018.0073DOI Listing
January 2018

Bilateral malignant paragangliomas in a patient: a rare case report.

World Neurosurg 2019 Jan 3. Epub 2019 Jan 3.

Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Background: Paragangliomas are neuroendocrine neoplasms that arise from the extra-adrenal paraganglia of the autonomic nervous system. Approximately 3% of all paragangliomas occur in the head and neck region. Most reported cases are benign and unilateral. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.131DOI Listing
January 2019
1 Read

Classic congenital adrenal hyperplasia and its impact on reproduction.

Fertil Steril 2019 Jan;111(1):7-12

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Women with classic congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. In virilizing CAH forms, such as 21-hydroxylase and 11β-hydroxylase deficiency, the low reported pregnancy rate is mainly secondary to a diminished desire to conceive. Optimal glucocorticoid and/or mineralocorticoid replacement, sufficient to normalize androgen and P levels in the follicular phase, allows natural conception in most cases. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.11.037DOI Listing
January 2019
1 Read

Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.

Int J Mol Sci 2019 Jan 3;20(1). Epub 2019 Jan 3.

Department of Pharmacology and Toxicology, Veterinary Faculty, Universidad Complutense de Madrid, 28040 Madrid, Spain.

We have tested the hypothesis that neuropathic pain acting as a stressor drives functional plasticity in the sympathoadrenal system. The relation between neuropathic pain and adrenal medulla function was studied with behavioral, immunohistochemical and electrophysiological techniques in rats subjected to chronic constriction injury of the sciatic nerve. In slices of the adrenal gland from neuropathic animals, we have evidenced increased cholinergic innervation and spontaneous synaptic activity at the splanchnic nerve⁻chromaffin cell junction. Read More

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http://www.mdpi.com/1422-0067/20/1/155
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http://dx.doi.org/10.3390/ijms20010155DOI Listing
January 2019
1 Read

Management of blunt adrenal gland injury in a community-based hospital.

Injury 2018 Dec 28. Epub 2018 Dec 28.

Department of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates.

Introduction: Injury of the adrenal gland in blunt trauma is rare. The routine usage of the whole body computed tomography (CT) scan helps in early diagnosis. We aimed to study the incidence, mechanism of injury, management, and outcome of adrenal injury in blunt trauma patients treated in a community-based hospital. Read More

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http://dx.doi.org/10.1016/j.injury.2018.12.033DOI Listing
December 2018
1 Read

Comparison of Technical Details and Short-term Outcomes of Single-incision Versus Multiport Laparoscopic Adrenalectomy.

Surg Laparosc Endosc Percutan Tech 2018 Dec 1. Epub 2018 Dec 1.

Department of General Surgery, Koc University, School of Medicine.

To date, the single-incision laparoscopic surgery (SILS) technique has been applied to a wide range of general surgical procedures; however, there are still scant data and debates on adrenal procedures. The aim of this study was to compare surgical outcomes of single-incision versus laparoscopic multiport adrenalectomy. The patients were divided into 2 study groups on the basis of the surgical approach: SILS (group 1) and multiport laparoscopic surgery (group 2). Read More

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http://dx.doi.org/10.1097/SLE.0000000000000596DOI Listing
December 2018

The Disparate Effects of Epinephrine and Norepinephrine on Hyperglycemia in Cardiovascular Surgery.

Heart Surg Forum 2018 Dec 19;21(6):E522-E526. Epub 2018 Dec 19.

Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia, USA.

Hyperglycemia is a metabolic derangement that frequently develops after cardiovascular surgery. The perioperative administration of inotropic and vasoactive agents, such as epinephrine and norepinephrine, are common in the management of cardiac surgery patients and are known to contribute to the development of postoperative hyperglycemia. We hypothesized that hemodynamic support with epinephrine exacerbates postoperative hyperglycemia to a greater degree than does treatment with norepinephrine. Read More

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http://dx.doi.org/10.1532/hsf.2008DOI Listing
December 2018
1 Read

Tranexamic acid for patients with nasal haemorrhage (epistaxis).

Cochrane Database Syst Rev 2018 Dec 31;12:CD004328. Epub 2018 Dec 31.

Royal National Throat, Nose and Ear Hospital, 330 Gray's Inn Road, London, UK, WC1X 8DA.

Background: Epistaxis (nosebleed) most commonly affects children and the elderly. The majority of episodes are managed at home with simple measures. In more severe cases medical intervention is required to either cauterise the bleeding vessel, or to pack the nose with various materials. Read More

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http://doi.wiley.com/10.1002/14651858.CD004328.pub3
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http://dx.doi.org/10.1002/14651858.CD004328.pub3DOI Listing
December 2018
16 Reads

Analysis of Cause of Endodontic Failure of C-Shaped Root Canals.

Scanning 2018 25;2018:2516832. Epub 2018 Nov 25.

Department of Conservative Dentistry, Seoul St. Mary's Dental Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

The purpose of this study was to analyze various characteristics and classification of C-shaped root canals and evaluate the causes of endodontic failure of C-shaped root canals by examining the resected root surface with an endodontic microscope and a scanning electron microscope (SEM). Forty-two teeth with C-shaped root canals were included in this study and had undergone intentional replantation surgery. Before surgery, periapical radiography and cone-beam computed tomography were taken. Read More

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http://dx.doi.org/10.1155/2018/2516832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286757PMC
January 2019
1 Read

Pheochromocytoma in Dogs Undergoing Adrenalectomy.

Vet Pathol 2018 Dec 30:300985818819174. Epub 2018 Dec 30.

7 Department of Comparative Biomedicine and Food Sciences, University of Padova, Legnaro PD, Italy.

Pheochromocytoma is frequent in dogs and carries a guarded prognosis. Current histological criteria may not predict malignant behavior in dogs, similar to humans. In humans, characterization of tumors has been refined using the pheochromocytoma of the adrenal gland scaled score (PASS) and by immunohistochemistry. Read More

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http://dx.doi.org/10.1177/0300985818819174DOI Listing
December 2018
1 Read

Transperitoneal versus retroperitoneal laparoscopic adrenalectomy for adrenal tumours in adults.

Cochrane Database Syst Rev 2018 12 30;12:CD011668. Epub 2018 Dec 30.

Department of Surgical Sciences, University of Torino, Corso Achille Mario Dogliotti 14, Turin, Italy, 10126.

Background: Laparoscopic adrenalectomy is an accepted treatment worldwide for adrenal gland disease in adults. The transperitoneal approach is more common. The retroperitoneal approach may be preferred, to avoid entering the peritoneum, but no clear advantage has been demonstrated so far. Read More

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http://dx.doi.org/10.1002/14651858.CD011668.pub2DOI Listing
December 2018

The vulnerability to interpersonal stress in eating disorders: The role of insecure attachment in the emotional and cortisol responses to the trier social stress test.

Psychoneuroendocrinology 2018 Dec 24;101:278-285. Epub 2018 Dec 24.

Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Background: Vulnerability to interpersonal stress is an important risk factor for Eating Disorders (EDs). Adult insecure attachment involves different emotional, biological and behavioural strategies to cope with social stressors. However, although attachment has proved to play a pivotal role in EDs, no study has yet explored the effects of attachment on the emotional and hypothalamic-pituitary-adrenal (HPA) axis responses to a psychosocial stressor in EDs. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2018.12.232DOI Listing
December 2018
1 Read

Ectopic relapse of IgG4-related disease presenting as IgG4-related sclerosing cholecystitis: A case report and review of literature.

Medicine (Baltimore) 2018 Dec;97(52):e13868

Department of Gastroenterology and Hepatology.

Rationale: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a chronic inflammatory disorder characterized by high levels of serum IgG4, swollen organs with fibrosis and abundant infiltration of IgG4-positive plasmacytes.

Patient Concerns: An 82-year-old male visited our hospital for an evaluation of a pancreatic enlargement and a bilateral submandibular adenopathy. Further investigation revealed elevation of serum IgG4 and bilateral lacrimal submandibular adenopathy. Read More

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http://dx.doi.org/10.1097/MD.0000000000013868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314772PMC
December 2018
8 Reads

Pembrolizumab for metastatic adrenocortical carcinoma with high mutational burden: Two case reports.

Medicine (Baltimore) 2018 Dec;97(52):e13517

Instituto do Cancer do Estado de São Paulo, University of Sao Paulo.

Rationale: In the setting of metastatic or locally advanced adrenocortical carcinoma, a limited number of therapies are available and their efficacy is generally below modest. The backbone of treatment remains surgery, even for metastatic disease, whenever it is possible, and mitotane. Chemotherapy can be used with limited results. Read More

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http://dx.doi.org/10.1097/MD.0000000000013517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314733PMC
December 2018
7 Reads

Unilateral Adrenalectomy Could Be a Valid Option for Primary Nodular Adrenal Disease: Evidence From Twins.

J Endocr Soc 2019 Jan 24;3(1):129-134. Epub 2018 Oct 24.

Division of Endocrinology, Hôpital Erasme, Brussels, Belgium.

Primary pigmented nodular adrenal disease (PPNAD) accounts for <1% of ACTH-independent Cushing syndrome. We describe the case of twin female patients with PPNAD who both had sustainable disease control after unilateral adrenalectomy, which corroborates current evidence in favor of unilateral adrenalectomy for a subset of patients with PPNAD. Patient A presented with a 10-kg weight gain over the past year and facial plethora. Read More

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http://dx.doi.org/10.1210/js.2018-00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302904PMC
January 2019
1 Read

Laparoscopic adrenalectomy for metastatic disease: Retrospective cohort with long-term, comprehensive follow-up.

Surgery 2018 Dec 24. Epub 2018 Dec 24.

Division of Endocrine Surgery, Department of Surgery, University of California, San Francisco, CA.

Background: Several malignancies metastasize to the adrenal gland, especially non-small cell lung cancer, renal cell carcinoma, and melanoma. Adrenalectomy is associated with prolonged survival, but laparoscopic adrenalectomy for this indication is controversial. Our objective was to characterize and quantify outcomes after laparoscopic adrenalectomy for metastases to the adrenal gland. Read More

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http://dx.doi.org/10.1016/j.surg.2018.11.008DOI Listing
December 2018
5 Reads

De Novo Testicular Extranodal NK/T-Cell Lymphoma: A Clinicopathologic Study of 21 Cases With Review of Additional 18 Cases in the Literature.

Am J Surg Pathol 2018 Dec 26. Epub 2018 Dec 26.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.

Although the testis is not uncommonly involved during the course of disease in both nasal and non-nasal extranodal NK/T-cell lymphoma (ENKTCL), only a few cases presenting initially with a testicular mass have been previously reported. These have been documented as case reports, rather than as study series. Because of its rarity, the clinicopathologic features and the prognosis of de novo testicular ENKTCL have not been well characterized. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001210DOI Listing
December 2018
1 Read

Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and Viscum album Extract Treatment: A Case Report.

Perm J 2018 ;23

Institute for Applied Epistemology and Medical Methodology, University of Witten/Herdecke, Freiburg, Germany.

Introduction: Epithelial ovarian cancer (EOC) has a poor prognosis in advanced stages. High-dose chemotherapy (HDC) was pursued in the 1990s but was not found to improve survival of patients with EOC in larger studies. Many patients with cancer use Viscum album extracts (VAE). Read More

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http://dx.doi.org/10.7812/TPP/18-025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307551PMC
January 2018
1 Read

Systemic safety of serial intralesional steroid injection for subglottic stenosis.

Laryngoscope 2018 Dec 24. Epub 2018 Dec 24.

Department of Otolaryngology-Head and Neck Surgery, Monash Health, Clayton, Victoria, Australia.

Objectives/hypothesis: Serial intralesional steroid injection (SILSI) has recently been proposed as an effective scar-modifying therapy for subglottic stenosis (SGS). We aimed to explore the systemic absorption of steroid following SILSI and to characterize the magnitude and chronicity of any effect observed. Specifically, we aimed to show that any effect resolves prior to the next intralesional injection. Read More

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http://dx.doi.org/10.1002/lary.27673DOI Listing
December 2018
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A Comparison of Global Longitudinal, Circumferential, and Radial Strain to Predict Outcomes After Cardiac Surgery.

J Cardiothorac Vasc Anesth 2018 Oct 24. Epub 2018 Oct 24.

Department of Outcomes Research, Cleveland Clinic, Cleveland, OH; Department of Cardiothoracic Anesthesia, Cleveland Clinic, Cleveland, OH. Electronic address:

Objective: Myocardial strain measured by speckle-tracking echocardiography detects subtle regional and global left ventricular dysfunction. Myocardial strain is measured in the longitudinal, circumferential, and radial dimensions; however, it is unclear which dimension of strain is the best predictor of postoperative outcomes.

Design: A secondary analysis of prospectively collected data from a clinical trial (NCT01187329). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10530770183095
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http://dx.doi.org/10.1053/j.jvca.2018.10.031DOI Listing
October 2018
7 Reads

The pituitary gland prevents shock-associated death by controlling multiple inflammatory mediators.

Biochem Biophys Res Commun 2019 Jan 20;509(1):188-193. Epub 2018 Dec 20.

Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. Electronic address:

Bacterial infections cause a major burden of disease worldwide. Sepsis and septic shock are life-threatening complications of infections. The hypothalamic-pituitary-adrenal (HPA) axis initiates the release of endogenous glucocorticoids that modulate the host stress response and acute inflammation during septic shock. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183275
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http://dx.doi.org/10.1016/j.bbrc.2018.12.101DOI Listing
January 2019
4 Reads

Return to the Emergency Room with or without Readmission after Endoscopic Transsphenoidal Surgery in Socioeconomically Disadvantaged Patients at an Urban Medical Center.

World Neurosurg 2018 Dec 19. Epub 2018 Dec 19.

Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, USA; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA. Electronic address:

Background: Although reducing 30-day hospital readmission is now a priority in neurosurgical quality improvement, postoperative emergency room (ER) visits remain poorly understood, particularly in populations with limited access to outpatient care. After endoscopic transsphenoidal surgery (ETS), the unique pathologies treated may engender a variety of surgical and metabolic complications-often dangerous, delayed, and non-specific in presentation.

Objective: To characterize the causes and timing of ER visits-with or without readmission-in this socioeconomically disadvantaged population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183286
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http://dx.doi.org/10.1016/j.wneu.2018.12.039DOI Listing
December 2018
3 Reads

Development of [F]FAMTO: A novel fluorine-18 labelled positron emission tomography (PET) radiotracer for imaging CYP11B1 and CYP11B2 enzymes in adrenal glands.

Nucl Med Biol 2018 Nov 9. Epub 2018 Nov 9.

School of Imaging Sciences & Biomedical Engineering, 4th floor Lambeth Wing, St Thomas' Hospital, King's College London, London SE1 7EH, United Kingdom. Electronic address:

Introduction: Primary aldosteronism accounts for 6-15% of hypertension cases, the single biggest contributor to global morbidity and mortality. Whilst ~50% of these patients have unilateral aldosterone-producing adenomas, only a minority of these have curative surgery as the current diagnosis of unilateral disease is poor. Carbon-11 radiolabelled metomidate ([C]MTO) is a positron emission tomography (PET) radiotracer able to selectively identify CYP11B1/2 expressing adrenocortical lesions of the adrenal gland. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.11.002DOI Listing
November 2018

Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis.

JAMA 2018 12;320(24):2564-2579

Department of Clinical Research, Rottapharm Biotech, Monza, Italy.

Importance: Even though osteoarthritis is a chronic and progressive disease, pharmacological agents are mainly studied over short-term periods, resulting in unclear recommendations for long-term disease management.

Objective: To search, review, and analyze long-term (≥12 months) outcomes (symptoms, joint structure) from randomized clinical trials (RCTs) of medications for knee osteoarthritis.

Data Sources And Study Selection: The databases of MEDLINE, Scopus, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched until June 30, 2018 (MEDLINE alerts through August 31, 2018) for RCTs of patients with knee osteoarthritis that had treatment and follow-up lasting 1 year or longer. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
Publisher Site
http://dx.doi.org/10.1001/jama.2018.19319DOI Listing
December 2018
18 Reads