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    The computed tomography adrenal wash-out analysis properly classifies cortisol secreting adrenocortical adenomas.
    Endocrine 2018 Jan 13. Epub 2018 Jan 13.
    Department of Endocrinology, University Hospital of Nancy, Nancy, France.
    Purpose: Adrenocortical lesions are characterized through imaging, hormonal and histopathological analysis. Our aim was to compare the radiological features of adrenocortical lesions with their cortisol-secreting status and histopathological Weiss score.

    Methods: Seventy five patients operated between 2004 and 2016 in the University Hospital of Nancy for either adrenocortical carcinomas (ACC) or adrenocortical adenomas (ACA) were enrolled in this study. Read More

    Posterior Retroperitoneoscopic Resection of Extra-adrenal Paraganglioma Located in the Aorto-caval Space.
    Ann Surg Oncol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea.
    Background: The posterior retroperitoneoscopic adrenalec tomy has several advantages compared with the transperitoneal approach such as a shorter and more direct route to the target organ, no breach of the intraperitoneal space, and no required retraction of the adjacent organs. It also is a safe procedure with a short learning curve.1-5 This report presents a challenging case of an extra-adrenal paraganglioma located in the aorto-caval space and managed using the retroperitoneal approach. Read More

    Parental decisional regret and views about optimal timing of female genital restoration surgery in congenital adrenal hyperplasia.
    J Pediatr Urol 2017 Dec 28. Epub 2017 Dec 28.
    Division of Pediatric Urology, Riley Hospital for Children at IU Health, IN, USA.
    Purpose: The role of female genital restoration surgery (FGRS) in girls with congenital adrenal hyperplasia (CAH) is controversial, with no long-term parent-reported outcomes available. Decisional regret (DR) affects most parents after their children's treatment of pediatric conditions, including hypospadias. We aimed to assess parental DR after FGRS in infancy or toddlerhood and explore optimal timing for surgery. Read More

    Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia.
    J Pediatr Urol 2017 Dec 21. Epub 2017 Dec 21.
    Division of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA; Center for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
    Background: Reduced fertility is a common potential problem among males with congenital adrenal hyperplasia (CAH), with nearly half experiencing impaired sperm production. The major cause of oligo/azoospermia in CAH is testicular adrenal rest tumors (TARTs). Studies indicate that ultrasound screening for TARTs should begin during childhood, yet it remains unclear whether boys with CAH are routinely screened for TARTs and/or counseled about infertility risk and potential interventions such as fertility testing and/or preservation. Read More

    Single center experience with laparoscopic adrenalectomy on a large clinical series.
    BMC Surg 2018 Jan 11;18(1). Epub 2018 Jan 11.
    Endocrine Surgery Unit, University of Perugia, Piazza dell'Università, 06123, Perugia, Italy.
    Background: Laparoscopic adrenalectomy is considered the gold standard technique for the treatment of benign small and medium size adrenal masses (<6 cm), due to low morbidity rate, short hospitalization and patient rapid recovery. The aim of our study is to analyse the feasibility and efficiency of this surgical approach in a broad spectrum of adrenal gland pathologies.

    Methods: Pre-operative, intra-operative and post-operative data from 126 patients undergone laparoscopic adrenalectomy between January 2003 and December 2015 were retrospectively collected and reviewed. Read More

    The impact of patient-, disease-, and treatment-related factors on survival in patients with adrenocortical carcinoma.
    Can Urol Assoc J 2017 Dec 22. Epub 2017 Dec 22.
    Division of Urology, Department of Surgery; Western University, London, ON, Canada.
    Introduction: Adrenal cortical carcinoma (ACC) is a rare and aggressive endocrine tumour. Most present with advanced disease and have poor prognosis. Optimal treatment includes complete surgical resection. Read More

    Laparoscopic Versus Open Adrenalectomy for Localized/Locally Advanced Primary Adrenocortical Carcinoma (ENSAT I-III) in Adults: Is Margin-Free (R0) Resection the Key Surgical Factor that Dictates Outcome?-A Review of the Literature.
    J Laparoendosc Adv Surg Tech A 2018 Jan 10. Epub 2018 Jan 10.
    3 Second Department of Propaedeutic Surgery, Laikon General Hospital, University of Athens Medical School , Athens, Greece .
    Background: The aim of this study was to review the current literature on the role of laparoscopic adrenalectomy (LA) in the treatment of primary adrenocortical carcinoma (ACC; European Network for the Study of Adrenal Tumors [ENSAT] I-III) in adults.

    Materials And Methods: Nonrandomized controlled trials published between January 1999 and February 2017 were identified by searching the Pubmed, EMBASE, Cochrane Library, and Google Scholar databases. Primary and secondary endpoints included surgical and pathological parameters (patients age, tumor size, ENSAT stage, type of surgical approach, and period of follow-up), surgical outcomes (operative time, estimated blood loss, length of hospital stay, conversion rate to laparotomy, R0 resection, and surgical margin's status), and oncological outcomes (rate of recurrence, disease-free survival [DFS], and overall survival [OS] rates). Read More

    Adrenal Oncocytic Neoplasm with Paradoxical Loss of Important Mitochondrial Steroidogenic Protein: The 18 kDA Translocator Protein.
    Case Rep Endocrinol 2017 26;2017:6734695. Epub 2017 Nov 26.
    Department of Pathology, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, FL 33136, USA.
    The adrenal glands produce a variety of hormones that play a key role in the regulation of blood pressure, electrolyte homeostasis, metabolism, immune system suppression, and the body's physiologic response to stress. Adrenal neoplasms can be asymptomatic or can overproduce certain hormones that lead to different clinical manifestations. Oncocytic adrenal neoplasms are infrequent tumors that arise from cells in the adrenal cortex and display a characteristic increase in the number of cytoplasmic mitochondria. Read More

    Visual outcomes, efficacy, and surgical complications associated with intracameral phenylephrine 1.0%/ketorolac 0.3% administered during cataract surgery.
    Clin Ophthalmol 2018 21;12:21-28. Epub 2017 Dec 21.
    New York University Medical Center, New York, NY, USA.
    Aim: The purpose of this study was to compare visual outcomes, surgical time, and perioperative surgical complications after intracameral use of either phenylephrine/ketorolac (P/K) or epinephrine (Epi) during cataract surgery.

    Methods: This was a single-center, retrospective case review of patients undergoing cataract surgery from August to November 2015. Of the 641 eyes of 389 patients who underwent cataract surgery, 260 eyes were administered phenylephrine 1. Read More

    Successful fertility outcome in a woman with 17ɑ-hydroxylase deficiency.
    Clin Endocrinol (Oxf) 2018 Jan 6. Epub 2018 Jan 6.
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
    17ɑ-hydroxylase deficiency (17OHD) is a rare variant of congenital adrenal hyperplasia (CAH) due to mutations in the CYP17A1 gene.1, 2 This gene encodes an enzyme that expresses both 17α-hydroxylase and 17,20-lyase activities affecting both adrenal and gonadal sex steroid production.1 Due to the location of the enzyme in the steroidogenic pathway impairment results in elevated corticosterone, deoxycorticosterone and progesterone together with low levels of cortisol, 11-deoxycortisol, dehydroepiandrosterone sulphate (DHEAS) and 17-hydroxyprogesterone. Read More

    Relative Contributions of Adductor Canal Block and Intrathecal Morphine to Analgesia and Functional Recovery After Total Knee Arthroplasty: A Randomized Controlled Trial.
    Reg Anesth Pain Med 2018 Jan 9. Epub 2018 Jan 9.
    From the Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, Toronto, Canada.
    Background And Objectives: Effective postoperative analgesia may enhance early rehabilitation after orthopedic surgery. This randomized double-blind trial investigates the relative contributions of adductor canal block and low-dose intrathecal morphine (ITM) to postoperative analgesia and functional recovery after total knee arthroplasty.

    Methods: Two-hundred one patients undergoing elective unilateral total knee arthroplasty under spinal anesthesia were randomized to 3 groups. Read More

    [Surgical strategies for non-metastatic adrenocortical carcinoma].
    Chirurg 2018 Jan 8. Epub 2018 Jan 8.
    Klinik für Radiologie, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
    Adrenocortical carcinomas (ACC) are rare but highly aggressive tumors. It is very difficult to differentiate small locally limited ACCs from benign adenomas. A spontaneous density >10 Hounsfield units in non-enhanced CT scan and a slow washout after contrast injection are suspicious of malignancy but with a low specificity. Read More

    Acute kidney injury due to povidone-iodine ingestion: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8879
    Department of Internal Medicine.
    Rationale: Povidone-iodine is a broad-spectrum antiseptic applied topically to treat wounds and prevent their infection. There have been several case reports of acute kidney injury (AKI) in burn patients after povidone-iodine irrigation and in patients receiving the substance as a sclerotherapy agent for management of lymphocele after renal transplantation. However, biopsy-confirmed AKI after ingestion of povidone-iodine has not previously been described. Read More

    Adrenocortical oncocytoma: 11 Case reports and review of the literature.
    Medicine (Baltimore) 2017 Dec;96(48):e8750
    Department of Urology.
    Rationale: Adrenocortical oncocytoma is an extremely rare tumor of the adrenal gland. Its diagnostic criteria and biological behavior has not yet reached a consensus. The purpose of this study is to investigate the clinical characteristics of adrenocortical oncocytoma. Read More

    Which factor is the most effective one in metabolic Sydrome on the outcomes after coronary artery bypass graft surgery? A cohort study of 5 Years.
    J Cardiothorac Surg 2018 Jan 4;13(1). Epub 2018 Jan 4.
    Department of Anesthesiology, Beijing Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, West District of Beijing, Beijing, 100037, China.
    Background: Metabolic Syndrome and diabetes mellitus are risk factors for cardiovascular disease. However, the effects of Metabolic Syndrome with or without diabetes on perioperative and long-term morbidity and mortality after Coronary Artery Bypass Graft remain unclear.

    Methods: An retrospective study was performed on 1166 patients who received isolated primary Coronary Artery Bypass Graft in Fuwai hospital. Read More

    Profound Prolonged Bradycardia and Hypotension after Interscalene Brachial Plexus Block with Bupivacaine.
    J Emerg Med 2017 Dec 30. Epub 2017 Dec 30.
    Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York.
    Background: Interscalene brachial plexus blocks have been a routinely performed method of anesthesia for shoulder surgery that decreases the need for general anesthesia, length of stay, and recovery time. We describe a case of bupivacaine toxicity after an interscalene block.

    Case Report: The patient was a 66-year-old man who presented to our Emergency Department by emergency medical services from an ambulatory surgery center where he had undergone rotator cuff surgery, with bradycardia and hypotension. Read More

    Mental Health and Disorders of Sex Development/Intersex Conditions in Iranian Culture: Congenital Adrenal Hyperplasia, 5-α Reductase Deficiency-Type 2, and Complete Androgen Insensitivity Syndrome.
    Arch Sex Behav 2018 Jan 2. Epub 2018 Jan 2.
    Department of Medical Psychology and Center of Expertise on Gender Dysphoria, VU University Medical Center, Amsterdam, The Netherlands.
    Sixty-one patients (22 patients with congenital adrenal hyperplasia [CAH] with a mean age of 14.86 years [range, 5-23], 20 patients with 5-α reductase deficiency type 2 [5α-RD-2] with a mean age of 19.5 years [range, 5-29], and 19 patients with complete androgen insensitivity syndrome [CAIS] with a mean age of 18. Read More

    Robotic-assisted laparoscopic surgery for pediatric tumors: a bicenter experience.
    J Robot Surg 2017 Dec 29. Epub 2017 Dec 29.
    Service de chirurgie viscérale pédiatrique, Hôpital de Clocheville-CHU de TOURS, 49 boulevard Béranger, 37044, Tours Cedex, France.
    Mini-invasive surgery is more and more integrated in pediatric surgery. The robotic-assisted surgery brought new advantages from which the patient and the surgeon could benefit compared to laparoscopy. Its use in oncological surgery is still controversial. Read More

    Complete remission of hypertension in a hemodialysis patient after adrenalectomy for primary aldosteronism and renal transplantation.
    CEN Case Rep 2017 Dec 29. Epub 2017 Dec 29.
    Department of Endocrinology and Hypertension, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
    A 64-year-old man was admitted to our hospital for the hormonal evaluation of a right adrenal adenoma. He had been diagnosed with severe proteinuria and hypertension, and antihypertensive treatment was started at the age of 60. His renal function gradually declined, and hemodialysis was begun at the age of 64. Read More

    Effect of Locally Administered Dexmedetomidine as Adjuvant to Levobupivacaine in Supraclavicular Brachial Plexus Block: Double-blind Controlled Study.
    Anesth Essays Res 2017 Oct-Dec;11(4):981-986
    Department of Anaesthesiology and Critical Care, BS Medical College, Bankura, West Bengal, India.
    Context: Brachial plexus block is effective with good postoperative analgesia in upper limb surgery has gained importance as it safe, low cost, and maintains stable hemodynamics intraoperatively. To decrease the onset time and prolong the duration of nerve block bicarbonate, opioids (morphine, fentanyl, etc.), sympathomimetic agents (epinephrine, phenylephrine, etc. Read More

    Oncocytic Adreno Cortical Tumors: Pathological Features of 16 Cases and Review of the Literature.
    J Environ Pathol Toxicol Oncol 2017 ;36(3):237-244
    Department of General Surgery, Ege University, Izmir, Turkey.
    Oncocytic neoplasms of the adrenal gland are extremely rare tumors. These tumors differ from their nononcocytic counterparts in some respects. The aim of this study was to review and discuss the clinical, histological, and immunohistochemical features of as well as the prognosis for these rare tumors. Read More

    Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report.
    Surg Case Rep 2017 Dec 28;3(1):131. Epub 2017 Dec 28.
    Department of Breast and Endocrine Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
    Background: Recent advance of genetic testing has contributed to the diagnosis of hereditary pheochromocytoma and paraganglioma (PPGL). The clinical characteristics of hereditary PPGL are varying among the types of mutational genes. It is still difficult to specify the pathognomonic symptoms in the case of rare genetic mutations. Read More

    [Relationship between functional constipation and brain-gut-microbiota axis].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Dec;20(12):1345-1347
    Research Institute of General Surgery, Jinling Hospital, Nanjing 210002, China.
    Although with the higher prevalence, the overall treatment result of functional constipation is still not satisfied at home and abroad. The diagnosis and treatment of functional constipation are still to focus on colon itself. Functional constipation has complex interactions among intestinal flora, intestinal autonomic nerve and central nervous system. Read More

    A Rare Differential Diagnosis of an Adrenal Mass: A Case Report.
    Case Rep Oncol 2017 Sep-Dec;10(3):981-986. Epub 2017 Nov 6.
    Department of Infectious Diseases, Kantonsspital Winterthur, Winterthur, Switzerland.
    Ten years after his last treatment for diffuse large B-cell lymphoma, a seemingly healthy, 64-year-old man presented for his lymphoma-related follow-up. Ultrasound revealed an impressive tumor in the right adrenal gland. Due to recurrent cancer therapies in the past, this seemed highly suspicious of a second malignancy, such as primary adrenal carcinoma. Read More

    The Safety and Efficacy of Combination Therapy of Sorafenib and Radiotherapy for Advanced Hepatocellular Carcinoma: A Retrospective Study.
    Intern Med 2017 Dec 27. Epub 2017 Dec 27.
    Department of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
    Background Sorafenib is a standard therapy for advanced hepatocellular carcinoma (HCC), whereas radiotherapy is effective for local control of extrahepatic spread (EHS) or macrovascular invasion (MVI). This study investigated the safety and efficacy of this combined therapy to treat advanced HCC. Methods This retrospective study reviewed 62 patients with advanced-stage HCC with EHS or MVI who received sorafenib therapy, excluding the patients with only lung metastases. Read More

    Giant Cavernous Hemangioma of the Adrenal Gland in an Elderly Patient.
    Intern Med 2017 Dec 27. Epub 2017 Dec 27.
    Department of Internal Medicine. Division of Diabetes, Metabolism and Endocrinology, Japan.
    Cavernous hemangioma is a rare, non-functional, benign adrenal tumor. Adrenal cavernous hemangioma is often diagnosed after surgery with a histologic examination. A 70-year-old man complaining of appetite loss was admitted to our hospital. Read More

    Whole-genome sequencing revealed armadillo repeat containing 5 (ARMC5) mutation in a Chinese family with ACTH-independent macronodular adrenal hyperplasia.
    Endocr J 2017 Dec 27. Epub 2017 Dec 27.
    Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
    Primary macronodular adrenal hyperplasia (PMAH), also known in the past as bilateral macronodular adrenalhyperplasia or adrenocorticotropin (ACTH)-independent macronodular adrenal hyperplasia, is a rare type of Cushing's syndrome (CS) and is associated with bilateralenlargement of the adrenal glands. It accounts for <1% of all endogenous cases of CS. In order toidentify the pathogenic mutations in the causative gene of (AIMAH pedigrees, Whole-genome sequencing of three patients in family I was used to retrieve candidate causative genes. Read More

    Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma.
    Hypertension 2018 Feb 26;71(2):317-325. Epub 2017 Dec 26.
    From the Department of Internal Medicine I, Endocrinology and Diabetes Unit (B.H., C.T.F., M.F., K.L., S.H.), Department of Nuclear Medicine (A.S., K.H., A.K.B., C.B.), and Comprehensive Cancer Center Wuerzburg (T.D., M.F.), University Hospital of Wuerzburg, University of Wuerzburg, Germany; Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Italy (P.M., T.A.W., S.M.); Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Germany (F.B., M.R., T.A.W., Y.R.); Department of Nuclear Medicine, Klinikum rechts der Isar der Technischen Universität München, Germany (M.M.); Endocrinology in Charlottenburg, Berlin, Germany (M.Q.); Department of General, Visceral, and Transplant Surgery, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Germany (N.R.); Department of Pathology, University of Würzburg, Germany (V.W.); Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, MS (C.E.G.-S.); Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Germany (A.-C.R.); ENDOC, Center for Endocrine Tumors, Hamburg, Germany (S.P.); Pharmaceutical Radiochemistry, Technische Universität München, Garching bei München, Germany (H.-J.W.); and Scintomics GmbH, Fürstenfeldbruck, Germany (S.K.).
    Primary aldosteronism is the most frequent cause of secondary hypertension and is associated with increased morbidity and mortality compared with hypertensive controls. The central diagnostic challenge is the differentiation between bilateral and unilateral disease, which determines treatment options. Bilateral adrenal venous sampling, currently recommended for differential diagnosis, is an invasive procedure with several drawbacks, making it desirable to develop novel noninvasive diagnostic tools. Read More

    Isolated unilateral adrenal gland hemorrhage following motor vehicle collision: a case report and review of the literature.
    J Med Case Rep 2017 Dec 26;11(1):358. Epub 2017 Dec 26.
    Department of General Surgery, Henry Ford Wyandotte Hospital, 2333 Biddle Ave, Wyandotte, MI, 48192, USA.
    Background: Adrenal gland trauma is a rare condition that typically stems from blunt force trauma, and is associated with multiple organ injuries. Alternatively, isolated adrenal gland trauma is extremely rare, accounting for only 1.5 to 4% of all adrenal trauma cases. Read More

    A pheochromocytoma case diagnosed as adrenal incidentaloma.
    Turk J Pediatr 2017 ;59(2):200-206
    Division of Pediatric Endocrinology Departments of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
    Vurallı D, Kandemir N, Clark G, Orhan D, Alikaşifoğlu A, Gönç N, Ekinci S, Özön A. A pheochromocytoma case diagnosed as adrenal incidentaloma. Turk J Pediatr 2017; 59: 200-206. Read More

    Carbon dioxide embolism during transoral robotic thyroidectomy: A case report.
    Head Neck 2017 Dec 22. Epub 2017 Dec 22.
    Department of Otolaryngology - Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.
    Background: Carbon dioxide (CO2 ) embolism is a serious, although rare, complication of remote access thyroidectomy using CO2 insufflation. Recently, we encountered a case of CO2 embolism during transoral thyroidectomy, and present it here with a review of the literature.

    Methods And Results: A 59-year-old female patient with papillary thyroid carcinoma underwent transoral robotic thyroidectomy with CO2 insufflation. Read More

    A randomized comparison between interscalene and combined infraclavicular-suprascapular blocks for arthroscopic shoulder surgery.
    Can J Anaesth 2017 Dec 19. Epub 2017 Dec 19.
    Department of Anesthesia, Montreal General Hospital, McGill University, Montreal, QC, Canada.
    Background: This randomized trial aimed to evaluate combined infraclavicular-suprascapular blocks (ICB-SSBs) as a diaphragm-sparing alternative to interscalene blocks (ISBs) for arthroscopic shoulder surgery. We hypothesized that ICB-SSB would provide equivalent postoperative analgesia to ISB 30 min after surgery without the risk of hemidiaphragmatic paralysis.

    Methods: Following research ethics board approval and written informed consent, participants in the ISB group received an ultrasound-guided ISB with 20 mL of levobupivacaine 0. Read More

    The effect of perineural dexamethasone on duration of sciatic nerve blockade: a randomized, double-blind study.
    Acta Anaesthesiol Scand 2017 Dec 20. Epub 2017 Dec 20.
    Department of Anaesthesiology and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark.
    Background: Major hindfoot and ankle surgery is associated with severe postoperative pain, which is effectively alleviated by combined sciatic and saphenous nerve blockade. Local anaesthetics with added dexamethasone consistently prolongs the duration of pain relief compared to local anaesthetics alone. However, whether the extended duration of pain relief is due to an effect on duration of sensorimotor block per se vs. Read More

    Stress-Dosed Glucocorticoids and Mineralocorticoids Before Intensive Endurance Exercise in Primary Adrenal Insufficiency.
    Clin J Sport Med 2017 Dec 19. Epub 2017 Dec 19.
    Endocrinology and Metabolism, Wake Forest University, Winston-Salem, NC.
    Patients with primary adrenal insufficiency (PAI) require increased doses of glucocorticoids and mineralocorticoids during stressors, such as surgery, trauma, and sepsis. Although current guidelines exist for dose adjustments in these situations, there is no accepted dosing regimen for patients with PAI participating in intensive endurance exercise. Given the extensive physiologic stress of events, such as marathons, triathlons, and similar events, it is likely that a "stress-dose" of adrenal replacement therapy will not only prevent adrenal crisis, but also improve performance. Read More

    Alterations in Hydrocortisone Pharmacokinetics in a Patient With Congenital Adrenal Hyperplasia Following Bariatric Surgery.
    J Endocr Soc 2017 Jul 21;1(7):994-1001. Epub 2017 Jun 21.
    National Institutes of Health Clinical Center, Bethesda, Maryland 20892.
    Management of adult patients with classic congenital adrenal hyperplasia (CAH) is challenging and often complicated by obesity, metabolic syndrome, and adverse cardiovascular risk. Alterations in weight can influence cortisol kinetics. A 19-year-old woman with classic CAH and morbid obesity experienced persistent elevations of androgen levels while receiving oral glucocorticoid therapy. Read More

    Functional Implications of LH/hCG Receptors in Pregnancy-Induced Cushing Syndrome.
    J Endocr Soc 2017 Jan 12;1(1):57-71. Epub 2017 Jan 12.
    Department of Physiology, Institute of Biomedicine, 20520 Turku, Finland.
    Context: Elevated human choriogonadotropin (hCG) may stimulate aberrantly expressed luteinizing hormone (LH)/hCG receptor (LHCGR) in adrenal glands, resulting in pregnancy-induced bilateral macronodular adrenal hyperplasia and transient Cushing syndrome (CS).

    Objective: To determine the role of LHCGR in transient, pregnancy-induced CS.

    Design Setting Patient And Intervention: We investigated the functional implications of LHCGRs in a patient presenting, at a tertiary referral center, with repeated pregnancy-induced CS with bilateral adrenal hyperplasia, resolving after parturition. Read More

    Maffucci Syndrome Associated With Adrenocorticotropic Hormone-Independent Bilateral Macronodular Adrenal Hyperplasia.
    J Endocr Soc 2017 Jan 12;1(1):51-56. Epub 2017 Jan 12.
    Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
    Context: Maffucci syndrome is a rare, nonhereditary, mesodermal dysplastic disease characterized by the presence of multiple hemangiomas and enchondromas. This pathological condition, which is often unrecognized, is associated with a high prevalence of benign and malignant endocrine tumors involving pituitary, adrenal, thyroid, and parathyroid glands.

    Case Description: We describe the case of a young patient presenting a history suggestive of secondary arterial hypertension and typical features of Maffucci syndrome (multiple hemangiomas and enchondromas), which were unrecognized over the previous 3 decades. Read More

    Reversal of a Blunted Follicle-Stimulating Hormone by Chemotherapy in an Inhibin B-Secreting Adrenocortical Carcinoma.
    J Endocr Soc 2017 Jan 12;1(1):46-50. Epub 2017 Jan 12.
    Departments of Endocrinology.
    Context: Adrenocortical carcinomas (ACCs) are revealed in 60% of cases by steroid hypersecretion. Alternatively, it is uncommon to observe a paraneoplastic syndrome due to a peptide oversecretion.

    Case Description: We describe a 60-year-old man with a right adrenal mass. Read More

    Liposomal Bupivacaine in Implant-Based Breast Reconstruction.
    Plast Reconstr Surg Glob Open 2017 Nov 20;5(11):e1559. Epub 2017 Nov 20.
    Department of Plastic Surgery, Loma Linda University, Loma Linda, Calif.
    Purpose: This study evaluates the role of liposomal bupivacaine in implant-based breast reconstruction.

    Methods: A prospective, randomized, single-blind trial of liposomal bupivacaine in implant-based breast reconstruction was performed. Patients in the control arm were treated with 20 mL 0. Read More

    Unusual branching pattern of celiac trunk associated with supernumerary hepatic arteries and abnormal adrenal venous drainage - case study and review of the literature.
    Folia Med Cracov 2017 ;57(3):29-36
    Department of Anatomy Jagiellonian University Medical College, Kopernika 12, Kraków, Poland.
    Celiac artery (trunk) is one of the three major arteries which arise from abdominal aorta. It's variations not seem to be very uncommon. A routine dissection of a male cadaver at Department of Anatomy Jagiellonian University revealed unusual branching pattern of the celiac trunk with numerous supernumerary hepatic arteries. Read More

    Leydig cell tumor of the testis, presenting with azoospermia.
    Reprod Med Biol 2017 Oct 20;16(4):392-395. Epub 2017 Jul 20.
    Asada Ladies ClinicNagoyaJapan.
    Case: A case of Leydig cell tumor, associated with azoospermia, is presented.

    Outcome: The levels of sex hormones obviously were decreased, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), with elevated testosterone. Computed tomography revealed no adrenal gland tumor, but a significant calcification in the right scrotal content was observed. Read More

    Complete remission of metastatic pheochromocytoma in 123I-metaiodobenzylguanidine scintigraphy after a single session of 131I-metaiodobenzylguanidine therapy: a case report.
    BMC Res Notes 2017 Dec 19;10(1):750. Epub 2017 Dec 19.
    Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
    Background: Pheochromocytomas are rare neuroendocrine tumors, with a malignancy frequency of approximately 10%. The treatment of malignant pheochromocytoma is palliative, and the traditional management strategy has limited efficacy. Furthermore, no clear criteria exist for the treatment of metastatic pheochromocytoma, especially for unresectable lesions. Read More

    Functional extra-adrenal paraganglioma of the retroperitoneum giving thoracolumbar spine metastases after a five-year disease-free follow-up: a rare malignant condition with challenging management.
    Pan Afr Med J 2017 29;28:94. Epub 2017 Sep 29.
    First Orthopaedic Department of 'Aristotle University of Thessaloniki', 'Papanikolaou' Hospital, Exohi, Thessaloniki, Greece.
    Paragangliomas are benign neoplasms that arise from the autonomic nervous system and the associated paraganglia. Although benign, they have been shown to possess metastatic potential. Extra-adrenal retroperitoneal paraganglioma with vertebral metastasis is considered very uncommon. Read More

    Laparoscopic adrenalectomy in children: A 25-case series and review of the literature.
    J Pediatr Surg 2017 Nov 28. Epub 2017 Nov 28.
    Ege University Faculty of Medicine, Department of Pediatric Surgery, Izmir, Turkey. Electronic address:
    Background: Laparoscopic adrenalectomy (LA) is the gold standard and is widely performed in adults, but its use in children is relatively new. We aim to present our experience in twenty-five children with diverse adrenal pathologies and to discuss an extensive review of pediatric LA in English literature.

    Methods: Medical records of children with adrenal tumors admitted to a tertiary center and treated with LA were reviewed. Read More

    Innovation in endocrine surgery: robotic versus laparoscopic adrenalectomy. Meta-analysis and systematic literature review.
    Oncotarget 2017 Nov 19;8(60):102392-102400. Epub 2017 Oct 19.
    Department of General Surgery, Urgency and Organ Transplantation, University of Palermo, Palermo, Italy.
    Several studies in the last years demonstrated the better surgical outcome of laparoscopic approach to adrenal gland. Laparoscopic surgery is more difficult to learn and requires different psychomotor skills than open surgery, especially with regard to complex maneuvers requiring precision and dexterity. The development of robotic platform with three-dimensional vision and increased degrees of freedom of the surgical instruments has the aim to overcome these problems. Read More

    Vaginal bleeding and a giant ovarian cyst in an infant with 21-hydroxylase deficiency.
    J Pediatr Endocrinol Metab 2017 Dec 18. Epub 2017 Dec 18.
    Clinic of Pediatric Endocrinology, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.
    Background: Increased adrenal androgen hormones in congenital adrenal hyperplasia (CAH) can rarely cause giant ovarian cysts in the neonatal period. Although the exact mechanism of the development of ovarian cysts is unknown, it is thought that increased androgen levels stimulate folicle development by increasing follicle stimulating hormone (FSH) levels.

    Case Presentation: A 16-day-old newborn with ambiguous genitalia was presented to our clinic. Read More

    Mass effect: a plethora of symptoms caused by an otherwise benign transitional pituitary meningioma. Case report.
    Rom J Morphol Embryol 2017 ;58(3):983-988
    Department of Plastic Surgery and Reconstructive Microsurgery, Emergency Clinical Hospital of Bucharest, Romania;
    Meningiomas are among the most commonly encountered tumors of the central nervous system, being more frequent in females. We present the case of a dyslipidemic male patient, previously diagnosed with coronary artery disease for which he previously underwent percutaneous coronary intervention with the placement of two bare metal stents on the left anterior descending artery. He was presented to the emergency department for atypical angina and a seven-day history of dizziness when switching from clino- to orthostatism, reduced visual acuity, diplopia and vomiting. Read More

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