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    1 OF 1069

    Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase (MELK) in Adrenocortical Carcinoma.
    Endocrinology 2018 May 21. Epub 2018 May 21.
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, Colorado Anschutz Medical Campus Aurora, CO.
    Adrenocortical carcinoma (ACC) is an aggressive cancer with a five-year survival less than 35%. Mortality remains high due to lack of targeted therapies. Using bioinformatic analyses, we identified Maternal Embryonic Leucine Zipper Kinase (MELK) as 4. Read More

    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2016 Sep;30(9):1134-1138
    Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
    Objective: To investigate the effectiveness of clitoroplasty of reserving the clitoris dorsal neurovascular bundle and the ventral complete urethral plate for genital virilization in girls with congenital adrenal hyperplasia (CAH).

    Methods: Between June 2000 and October 2015, 27 girls with genital virilization were treated with clitoroplasty of reserving the clitoris dorsal neurovascular bundle and the ventral complete urethral plate. The chromosomal karyotype was 46, XX in all patients, whose age ranged from 3 to 11 years (mean, 3. Read More

    Dehydroepiandrosterone: molecular mechanisms and therapeutic implications in osteoarthritis.
    J Steroid Biochem Mol Biol 2018 May 19. Epub 2018 May 19.
    (b)Department of Orthopedic Surgery, The Second Hospital of Medical College, Zhejiang University, China.
    Dehydroepiandrosterone (DHEA), a 19-carbon steroid hormone primarily synthesized in the adrenal gland, exerts a chondroprotective effect against osteoarthritis (OA) and has been considered an effective candidate of disease-modifying OA drugs (DMOADs) that slow disease progression. We and others previously demonstrated that DHEA exerted a beneficial effect on osteoarthritic cartilage by positively modulating the balance between anabolic and catabolic factors (e.g. Read More

    Corticoadrenal and Cardiorespiratory Responses to Administration of Propofol Combined with Dexmedetomidine or Ketamine in Rabbits.
    J Am Assoc Lab Anim Sci 2018 May;57(3):278-281
    Department of Animal Physiology, Veterinary Medicine School, Complutense University of Madrid, Madrid, Spain.
    Anesthetic protocols may influence adrenal function. Effective methods for modulating stress are desirable to minimize secondary effects during the perioperative period. The aim of this study was to evaluate the effects of the administration of propofol with dexmedetomidine or ketamine on corticoadrenal function and heart and respiratory rates. Read More

    Over-diagnosis of potential malignant behavior in MEN 2A-associated pheochromocytomas using the PASS and GAPP algorithms.
    Langenbecks Arch Surg 2018 May 19. Epub 2018 May 19.
    Department of Oncology-Pathology, Karolinska Institutet, CCK, Karolinska University Hospital, R8:04, 171 76, Solna, Stockholm, Sweden.
    Purpose: Pheochromocytomas (PCCs) exhibit malignant potential, but current histological modalities for the proper detection of aggressive behavior are debated. The two most widespread algorithms are the "Pheochromocytoma of the Adrenal Gland Scaled Score" (PASS) and the "Grading System for Adrenal Pheochromocytoma and Paraganglioma" (GAPP), both which mostly rely on histological parameters to identify PCC patients at risk of disseminated disease. Since the algorithms are derived from studies using predominantly sporadic PCCs, little is known whether the PASS or GAPP scores can predict malignant potential in hereditary cases. Read More

    Mindfulness Meditation and Interprofessional Cardiopulmonary Resuscitation: A Mixed-Methods Pilot Study.
    Teach Learn Med 2018 May 18:1-11. Epub 2018 May 18.
    a Department of Internal Medicine; Division of Pulmonary and Critical Care Medicine , Mayo Clinic Minnesota , Rochester , Minnesota , USA.
    Problem: Mindfulness training includes mindfulness meditation, which has been shown to improve both attention and self-awareness. Medical providers in the intensive care unit often deal with difficult situations with strong emotions, life-and-death decisions, and both interpersonal and interprofessional conflicts. The effect of mindfulness meditation training on healthcare providers during acute care tasks such as cardiopulmonary resuscitation remains unknown. Read More

    Robot-Assisted Laparoscopic Adrenalectomy.
    J Endourol 2018 May;32(S1):S82-S87
    Department of Surgery, Section of Urology, University of Chicago Medical Center , Chicago, Illinois.
    Adrenalectomies are increasingly performed using minimally invasive approaches. The widespread adoption of robot-assisted laparoscopy for other urologic surgeries has dramatically increased the popularity of this approach for adrenal surgery. Read More

    Varicocele and Testicular Pain: A Review.
    World J Mens Health 2018 May 16. Epub 2018 May 16.
    Department of Urology, Konkuk University School of Medicine, Seoul, Korea.
    Varicocele is the dilatation of the scrotal portion of pampiniform plexus and the internal spermatic venous system. About 15% of men suffer from scrotal varicocele and 2% to 10% of them complain of pain. The probable mechanisms for pain include compression of the surrounding neural fibers by the dilated venous complex, elevated testicular temperature, increased venous pressure, hypoxia, oxidative stress, hormonal imbalances, and the reflux of toxic metabolites of adrenal or renal origin. Read More

    Determinants and Outcomes of Vasoplegia Following Left Ventricular Assist Device Implantation.
    J Am Heart Assoc 2018 May 17;7(11). Epub 2018 May 17.
    Department of Cardiology, Baylor University Medical Center, Dallas, TX
    Background: Vasoplegia is associated with adverse outcomes following cardiac surgery; however, its impact following left ventricular assist device implantation is largely unexplored.

    Methods And Results: In 252 consecutive patients receiving a left ventricular assist device, vasoplegia was defined as the occurrence of normal cardiac function and index but with the need for intravenous vasopressors within 48 hours following surgery for >24 hours to maintain a mean arterial pressure >70 mm Hg. We further categorized vasoplegia as ; , requiring 1 vasopressor (vasopressin, norepinephrine, or high-dose epinephrine [>5 μg/min]); or , requiring ≥2 vasopressors. Read More

    Synchronous adrenocortical carcinoma and ovarian malignant mixed germ cell tumor: A case report and literature review.
    Medicine (Baltimore) 2018 May;97(20):e10730
    Department of Pathology, West China Second Hospital of Sichuan University.
    Rationale: Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors.

    Patient Concerns: We report a case of a 29-year-old woman with ACC synchronously followed by an ovarian malignant mixed germ cell tumor. Read More

    C-Arm Computed Tomography-Assisted Adrenal Venous Sampling Improved Right Adrenal Vein Cannulation and Sampling Quality in Primary Aldosteronism.
    Endocrinol Metab (Seoul) 2018 May 4. Epub 2018 May 4.
    Department of Internal Medicine, Endocrine Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: Adrenal venous sampling (AVS) is a gold standard for subtype classification of primary aldosteronism (PA). However, this procedure has a high failure rate because of the anatomical difficulties in accessing the right adrenal vein. We investigated whether C-arm computed tomography-assisted AVS (C-AVS) could improve the success rate of adrenal sampling. Read More

    Adrenal Incidentalomas During Diagnostic Work-up of Colorectal Cancer Patients: What is the Risk of Metastases?
    Ann Surg Oncol 2018 May 14. Epub 2018 May 14.
    Surgery, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands.
    Background: Adrenal incidentalomas (AIs) are regularly discovered on staging computed tomography (CT) of patients with colorectal cancer (CRC). Although CRC is considered unlikely to metastasize to the adrenal gland, it is not known how often an AI appears to be a CRC metastasis. This causes a diagnostic dilemma for many patients with newly diagnosed CRC. Read More

    Best Prophylactic Strategy in Groups at Risk of Intraoperative Floppy Iris Syndrome Development: Comparison Between Atropine Instillation and Adrenaline Intracameral Injection.
    Open Ophthalmol J 2018 30;12:34-40. Epub 2018 Mar 30.
    Eye Clinic Section and Specialization School in Ophthalmology, Institute of Ophthalmology, Department of Surgical Sciences, University of Turin, Turin, Italy.
    Background: Intraoperative Floppy Iris Syndrome (IFIS) is an important cause of surgical complications and iris defects in patients undergoing phacoemulsification that were treated with selective subtype α1A receptor antagonists for a long period of time. To date, no definitive preventive strategy has emerged, yet. The need of prophylaxis is dictated by the high prevalence of males affected by benign prostatic hyperplasia undergoing cataract surgery. Read More

    Effect of Intravenous Fluid Volumes on the Adrenal Glucocorticoid Response after Burn Injury in Swine.
    J Burn Care Res 2018 May 11. Epub 2018 May 11.
    United States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA.
    Objective: Severe thermal injury induces metabolic and physiological stress, prompting a disruption in the hypothalamic-pituitary-adrenal axis. The objective of this study was to evaluate potential confounding effects of Lactated Ringer's (LR) resuscitation on adrenal damage and cortisol production following burn.

    Methods: Anesthetized swine were instrumented with jugular catheters and sustained 40% TBSA burns from brass probes heated to 100ºC. Read More

    Efficacy and pharmacokinetics of bupivacaine with epinephrine or dexmedetomidine after intraperitoneal administration in cats undergoing ovariohysterectomy.
    Can J Vet Res 2018 Apr;82(2):124-130
    Department of Clinical Sciences (Benito, Steagall), Biomedical Sciences (Monteiro, Beaudry), and Animal Pharmacology Research Group of Quebec (GREPAQ; Groupe de recherche en pharmacologie animale du Québec) (Monteiro, Beaudry, Steagall), Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec J2S 2M2.
    The aim of this study was to determine the efficacy and pharmacokinetics of bupivacaine in combination with epinephrine or dexmedetomidine after intraperitoneal administration in cats undergoing ovariohysterectomy. Sixteen healthy adult cats (3.3 ± 0. Read More

    Cushing's Syndrome in Pediatrics: An Update.
    Endocrinol Metab Clin North Am 2018 Jun;47(2):451-462
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1E-3330, MSC1103, Bethesda, MD 20892, USA.
    Cushing syndrome (CS) is a multisystem disorder resulting from the prolonged exposure to excess glucocorticoids. In children, CS most commonly results from the exogenous administration of steroids and the typical presentation is height deceleration concomitant with weight gain. Endogenous and ectopic causes are rare. Read More

    Adrenal Surgery for Cushing's Syndrome: An Update.
    Endocrinol Metab Clin North Am 2018 Jun 9;47(2):385-394. Epub 2018 Apr 9.
    Department of Medicine IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Ziemssenstraße 1, München 80336, Germany. Electronic address:
    Recent advances in the molecular pathogenesis and the natural history of Cushing's syndrome have improved the understanding of the management of this disease. The long-term efficacy of several cortisol-lowering medical treatments is currently under evaluation. However, adrenalectomy is a safe option for the treatment of patients affected by Cushing's syndrome. Read More

    The Role of Dipyrone in the High Development of On-Treatment Platelet Reactivity in Acetylsalicylic Acid Treated Patients Undergoing Peripheral Artery Revascularization.
    Med Princ Pract 2018 May 13. Epub 2018 May 13.
    Objective: To evaluate the effects of dipyrone on sensitivity to Aspirin [acetyl salicylic acid, (ASA)] in patients who underwent peripheral artery vascular reconstruction.

    Subjects And Methods: Impedance aggregometry and light transmission aggregometry were used to determine the effects of dipyrone on ASA treatment in 21 patients. Blood samples were drawn in a 7-day period after the surgery. Read More

    Acute adrenal cortex injury during cardiopulmonary bypass in a canine model.
    J Thorac Cardiovasc Surg 2018 Apr 11. Epub 2018 Apr 11.
    Department of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China. Electronic address:
    Objective: Cardiopulmonary bypass (CPB) might induce systemic inflammatory responses that cause acute injuries to multiple organs. However, no direct evidence exists to determine whether CPB leads to adrenal cortex injury or to describe its underlying mechanism.

    Methods: Twelve healthy adult beagles were randomly assigned into control and CPB groups. Read More

    Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study.
    Environ Int 2018 May 9;117:175-185. Epub 2018 May 9.
    Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan. Electronic address:
    Background: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis.

    Objective: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones.

    Methods: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. Read More

    Bilateral Posterior Mediastinal Primary Myelolipoma.
    Ann Thorac Surg 2018 May 8. Epub 2018 May 8.
    Radiodiagnosis, Lady Hardinge Medical College, New Delhi-110001, India.
    Myelolipoma(ML) is an uncommon benign mesenchymal tumor consisting of mature adipocytes and hemopoietic elements mostly found in adrenal glands. Bilateral posterior mediastinal primary myelolipoma presents extremely rarely and only 11 such occurrences have been previously described. With no definite symptoms, pathological evaluation is essential for diagnosis. Read More

    Relative Adrenal Insufficiency is Associated with Prolonged Postoperative Hemodynamic Instability.
    Ann Thorac Surg 2018 May 8. Epub 2018 May 8.
    Division of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Montreal, Canada. Electronic address:
    Background: We assessed the hypothesis that a significant proportion of patients undergoing cardiac surgery suffer from postoperative relative adrenal insufficiency (RAI), and that this puts them at higher risk of persistent hemodynamic instability.

    Methods: A prospective study included 135 patients who underwent cardiac surgery using cardiopulmonary bypass between July 2006 and December 2007. Adrenal function was assessed 36 hours after surgery using a 1 μg cosyntropin (ACTH) stimulation test. Read More

    Proximal Versus Distal Continuous Adductor Canal Blocks: Does Varying Perineural Catheter Location Influence Analgesia? A Randomized, Subject-Masked, Controlled Clinical Trial.
    Anesth Analg 2018 May 9. Epub 2018 May 9.
    From the Department of Anesthesiology, University of California San Diego, San Diego, California.
    Background: A continuous adductor canal block provides analgesia after surgical procedures of the knee. Recent neuroanatomic descriptions of the thigh and knee led us to speculate that local anesthetic deposited in the distal thigh close to the adductor hiatus would provide superior analgesia compared to a more proximal catheter location. We therefore tested the hypothesis that during a continuous adductor canal nerve block, postoperative analgesia would be improved by placing the perineural catheter tip 2-3 cm cephalad to where the femoral artery descends posteriorly to the adductor hiatus (distal location) compared to a more proximal location at the midpoint between the anterior superior iliac spine and the superior border of the patella (proximal location). Read More

    Characteristics of Adrenal Incidentalomas in a Large, Prospective Computed Tomography-Based Multicenter Study: The COAR Study in Korea.
    Yonsei Med J 2018 Jun;59(4):501-510
    Division of Endocrinology and Metabolism, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
    Purpose: Previous studies on adrenal incidentalomas (AIs) are limited by their retrospective design, small numbers of patients, Western populations, or use of an outdated imaging technique. We investigated the characteristics of AIs in Korean patients and compared them with those reported in the largest retrospective study in Italy to discover the effects of improved imaging techniques and ethnicity differences.

    Materials And Methods: This was a prospective, multicenter, cross-sectional observational study including 1005 Korean patients. Read More

    Pheochromocytoma as a rare cause of hypertension in a 46 X, i(X)(q10) turner syndrome: a case report and literature review.
    BMC Endocr Disord 2018 May 10;18(1):27. Epub 2018 May 10.
    Department of Internal Medicine, Pusan National University College of Medicine, Busan, 49241, South Korea.
    Background: Cardiovascular disease (CVD) presents the most serious health problems and contributes to the increased mortality in young women with Turner syndrome. Arterial hypertension in Turner syndrome patients is significantly more prevalent than that in a general age-matched control group. The aetiology of hypertension in Turner syndrome varies, even in the absence of cardiac anomalies and obvious structural renal abnormalities. Read More

    Nitric oxide alterations in cardiovascular system of rats with Parkinsonism induced by 6-OHDA and submitted to previous exercise.
    Life Sci 2018 May 7. Epub 2018 May 7.
    Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina - UEL, Londrina, PR, Brazil. Electronic address:
    Studies showed that physical exercise decreases the risk of developing Parkinson's disease (PD) as slowing its progression. During aerobic training, nitric oxide (NO) increases in the substantia nigra pars compacta (SNpc) of individuals with PD. However, no study has evaluated the effects of exercise on peripheral NO levels and its modulatory effects on cardiovascular dysfunctions of subjects with PD. Read More

    Reduced Hemidiaphragmatic Paresis With a "Corner Pocket" Technique for Supraclavicular Brachial Plexus Block: Single-Center, Observer-Blinded, Randomized Controlled Trial.
    Reg Anesth Pain Med 2018 May 10. Epub 2018 May 10.
    Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
    Background And Objective: Hemidiaphragmatic paresis is common after supraclavicular brachial plexus block (SCBPB). In this randomized trial, we compared the incidence of hemidiaphragmatic paresis in patients who had local anesthetic injected primarily in the corner pocket (defined as the intersection of the first rib and subclavian artery) during SCBPB with that of patients who underwent injection primarily inside the neural cluster.

    Methods: Thirty-six patients scheduled for right elbow, forearm, wrist, or hand surgery under SCBPB (using 12. Read More

    The role of intraoperative stroke volume variation on bleeding during functional endoscopic sinus surgery.
    Minerva Anestesiol 2018 May 9. Epub 2018 May 9.
    Anesthesia and Intensive Care Medicine Unit, Department of Clinical Sciences and Translational Medicine, University of Tor Vergata, Rome, Italy.
    BACKGROUNDː Functional Endoscopic Sinus Surgery (FESS) is a minimally-invasive surgical technique for patients with paranasal sinus pathology. Surgical bleeding reduces operative field visibility and increases the incidence of serious complications. Epinephrine injection into the nasal mucosa and controlled hypotension are used to minimise bleeding. Read More

    Pituitary apoplexy following lumbar fusion surgery in prone position: A case report.
    Medicine (Baltimore) 2018 May;97(19):e0676
    Department of Anesthesia and Pain Medicine, Incheon St. Mary's hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea.
    Rationale: Pituitary apoplexy (PA) is a syndrome caused by acute hemorrhage or infarction of the pituitary gland, generally within a pituitary adenoma. PA following spinal surgery is a very rare complication and may be difficult to diagnose. However, early diagnosis of PA is essential for the timely treatment of pan-hypopituitarism and prevention of severe neurologic complications. Read More

    The effectiveness and safety of nonsurgical integrative interventions for symptomatic lumbar spinal spondylolisthesis: A randomized controlled multinational, multicenter trial protocol.
    Medicine (Baltimore) 2018 May;97(19):e0667
    Korean Medicine Clinical Trial Center, Korean Medicine Hospital, Kyung Hee University, Seoul, Republic of Korea.
    Background: Surgery is generally accepted as the main therapeutic option for symptomatic lumbar spondylolisthesis. However, new nonsurgical therapeutic options need to be explored for this population.

    Objectives: The objective of this study is to assess the effectiveness and safety of a 5-week Mokhuri treatment program compared with conventional nonsurgical treatments for symptomatic lumbar spondylolisthesis. Read More

    Giant malignant pheochromocytoma in an elderly patient: A case report.
    Medicine (Baltimore) 2018 May;97(19):e0614
    Department of Urology, Tianjin Nankai Hospital, Tianjin, China.
    Rationale: Malignant pheochromocytoma is a rare disease and surgical resection is the only curative treatment.

    Patient Concerns: An 81-year-old man of Chinese ethnicity was found to have a giant retroperitoneal tumor.

    Diagnoses: B-scan ultrasonography and CT scan presented a mass above the left kidney, measuring 13. Read More

    Role of DOTATATE-PET/CT in preoperative assessment of phaeochromocytoma and paragangliomas.
    Clin Endocrinol (Oxf) 2018 May 9. Epub 2018 May 9.
    Department of Endocrinology and Diabetes, Royal North Shore Hospital, Sydney, Australia.
    Context: Diagnosis of paragangliomas (PGL) and phaeochromocytomas (PC) can be challenging particularly if the tumour is small. Detection of metastatic disease is important for comprehensive management of malignant PC/PGL. Somatostatin receptor imaging (SRI) agents have high sensitivity for these tumours, particularly the DOTA family of radiopharmaceuticals labelled with Gallium. Read More

    Surgical management of large adrenal tumors: impact of different laparoscopic approaches and resection methods on perioperative and long-term outcomes.
    BMC Urol 2018 May 8;18(1):31. Epub 2018 May 8.
    Department of Urology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu, 641000, Sichuan, China.
    Background: The indication of retroperitoneal laparoscopic adrenalectomy (RLA) was extended with the retroperitoneal approach and has been wildly accepted and technologically matured. However, the management of large adrenal tumors via this approach still remains controversial. The aim of this study was to perform a comprehensive analysis on the minimally invasive surgical management of larger adrenal tumors. Read More

    Posterior mediastinal myelolipoma resected by video-assisted thoracic surgery.
    J Minim Access Surg 2018 May 4. Epub 2018 May 4.
    Department of Medicine and Surgery, Thoracic Surgery, University Hospital of Parma, Parma, Italy.
    Myelolipoma (ML) is a benign tumour composed of haematopoietic and mature adipose tissue commonly found in adrenal glands. Prognosis is usually good with an indolent clinical course. The occurrence of an ML in the extra-adrenal site is very rare. Read More

    CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells.
    PLoS One 2018 7;13(5):e0196931. Epub 2018 May 7.
    Internal Medicine, Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Orbassano, Turin, Italy.
    Mitotane is the reference drug for adrenocortical carcinoma (ACC) and the metabolic activation of the drug is considered as essential for its activity. The aim of this study was to assess the role of CYP11B1 on mitotane action and metabolism in H295R ACC cells to understand whether this enzyme may influence mitotane action. The simultaneous incubation with mitotane and metyrapone, an adrenolytic molecule targeting 11-beta-hydroxylase, did not influence mitotane-mediated cytotoxic effect and metabolism in H295R ACC cells. Read More

    Corticosteroids in Pediatric Heart Surgery: Myth or Reality.
    Front Pediatr 2018 20;6:112. Epub 2018 Apr 20.
    Department of Cardiac Surgery, Bristol Heart Institute, Bristol, United Kingdom.
    Corticosteroids have been administered prophylactically for more than 60 years in pediatric heart surgery, however, their use remains a matter of debate. There are three main indications for corticosteroid use in pediatric heart surgery with the use of cardiopulmonary bypass (CPB): (1) to blunt the systemic inflammatory response (SIRS) induced by the extracorporeal circuit; (2) to provide perioperative supplementation for presumed relative adrenal insufficiency; (3) for the presumed neuroprotective effect during deep hypothermic circulatory arrest operations. This review discusses the current evidence behind the use of corticosteroids in these three overlapping areas. Read More

    A pediatric carotid body tumor.
    J Pediatr Surg 2018 Apr 7. Epub 2018 Apr 7.
    Department of Otolaryngology, Division of Pediatric Otolaryngology, University of Miami Miller School of Medicine, Miami, FL.
    Carotid body tumors are rare childhood extra-adrenal paragangliomas. We present an 8-year old female with a neck mass mistaken as reactive lymphadenopathy. Computed tomography and magnetic resonance angiography, as well as preoperative embolization and balloon test occlusion, were utilized for planning and management. Read More

    Root cause analysis of diagnostic and surgical failures in the treatment of suspected Cushing's disease.
    J Clin Neurosci 2018 Apr 28. Epub 2018 Apr 28.
    Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
    Cushing's disease (CD) is a condition characterized by excess glucocorticoid from an ACTH pituitary adenoma. Identifying surgical candidates represents a major diagnostic challenge. We performed a root cause analysis (RCA) of treatment failures for patients with suspected CD. Read More

    Hershberger Assays for Di-2-ethylhexyl Phthalate and Its Substitute Candidates.
    Dev Reprod 2018 Mar 31;22(1):19-27. Epub 2018 Mar 31.
    Dept. of Biotechnology, Sangmyung University, Seoul 03016, Korea.
    In the present study, we employed Hershberger assay to determine possible androgenic or antiandrogenic activities of three di-2-ethylhexyl phthalate (DEHP) substitute candidates. The assay was carried out using immature castrated Sprague-Dawley male rats. After 7 days of the surgery, testosterone propionate (TP, 0. Read More

    Treating Hypotension in Preterm Neonates With Vasoactive Medications.
    Front Pediatr 2018 13;6:86. Epub 2018 Apr 13.
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
    Preterm neonates often have hypotension which may be due to various etiologies. While it is controversial to define hypotension in preterm neonates, various vasoactive medications are commonly used to provide the cardiovascular support to improve the blood pressure, cardiac output, or to treat shock. However, the literature on the systemic and regional hemodynamic effects of these antihypotensive medications in neonates is deficient and incomplete, and cautious translation of findings from other clinical populations and animal studies is required. Read More

    Percutaneous Intramedullary Headless Screw Fixation and Anesthesia to Treat Metacarpal Fractures: Early Results in 25 Patients.
    J Hand Microsurg 2018 Apr 20;10(1):16-21. Epub 2018 Mar 20.
    Orthopaedic and Trauma Unit, University Hospital of Pisa, Pisa, Italy.
    Metacarpal fractures constitute 7.8% of the upper extremity fractures. The common treatments remain nonsurgical procedure, but high-demanding patients or unstable fractures require fixation with Kirschner wire (K-wires), plate, and screws. Read More

    Role of Local Anaesthetic Nerve Block in Endoscopic Sinus Surgery: a systematic review and meta-analysis.
    Clin Otolaryngol 2018 Apr 29. Epub 2018 Apr 29.
    Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT.
    Objective: The aim of the study was to perform a systematic review of existing evidence on the role of local anaesthetic nerve block (LAB) in patients undergoing endoscopic sinus surgery (ESS).

    Design: The databases searched were the Cochrane Register of Controlled Trials, MEDLINE and Embase using the Ovid portal (1946-2017).

    Results: Seven randomised controlled trials were included. Read More

    Treatment of Ramsay-Hunt's syndrome with multiple cranial nerve involvement and severe dysphagia: A case report.
    Medicine (Baltimore) 2018 Apr;97(17):e0591
    Department of Rehabilitation Medicine, Daegu Fatima Hospital.
    Rationale: Ramsay-Hunt's syndrome (RHS) is a disorder characterized by facial paralysis, herpetic eruptions on the auricle, and otic pain due to the reactivation of latent varicella zoster virus in the geniculate ganglion. A few cases of multiple cranial nerve invasion including the vestibulocochlear nerve, glossopharyngeal nerve and vagus nerve have been reported. However, there has been no report about RHS with delayed onset multiple cranial nerve involvement causing severe aspiration, and a clinical course that improved after more than one year of dysphagia rehabilitation and percutaneous endoscopic gastrostomy (PEG). Read More

    Robotic excision of complex adrenal mass with retrocaval extension and encasement of renal hilum with renal preservation.
    Int Braz J Urol 2018 Apr 5;44. Epub 2018 Apr 5.
    Aster Medcity, Kochi, Kerala, India.
    Objective: The purpose of this video is to present robotic excision of a complex adrenal mass with retrocaval extension and encasement of renal hilum in a 16 year old boy. Biochemical screening was negative for metabolically active component. Computerized tomographic scan with contrast revealed a homogenous mass of approximately 10. Read More

    Population Pharmacokinetics of Periarticular Ketorolac in Adult Patients Undergoing Total Hip or Total Knee Replacement Surgery.
    Anesth Analg 2018 Apr 23. Epub 2018 Apr 23.
    Faculty of Medicine, University of Queensland Centre for Clinical Research.
    Background: Ketorolac tromethamine has been used for joint infiltration by the orthopedic surgeons as a part of postoperative multimodal analgesia. The objective of this study is to investigate the pharmacokinetic properties of S (-) and R (+) enantiomers of ketorolac in adult patients undergoing total hip (THA) and knee arthroplasty (TKA).

    Methods: Adult patients with normal preoperative renal function received a periarticular infiltration of 30 mg of ketorolac tromethamine along with 100 mL of 0. Read More

    Laparoscopic versus robotic adrenalectomy: a review of the national inpatient sample.
    J Robot Surg 2018 Apr 25. Epub 2018 Apr 25.
    Geisinger Medical Center, 100 N. Academy Avenue, MC 21-69, Danville, PA, 17822, USA.
    Background: Laparoscopic adrenalectomy (LA) has become the standard treatment of adrenal lesions. Recently, robotic-assisted adrenalectomy (RA) has become an option, however, short-term outcomes for RA have not been well studied and benefits over LA are debatable. The aim of this study was to explore differences in short-term outcomes between LA and RA using the national inpatient sample (NIS) database. Read More

    A case of TSH-secreting pituitary adenoma with cyclic fluctuations in serum TSH levels.
    Endocr J 2018 Apr 26. Epub 2018 Apr 26.
    Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
    A 29-year-old man was referred to our department due to adrenal insufficiency with the inappropriate secretion of TSH (SITSH). Magnetic resonance imaging revealed a pituitary tumor. A weak TSH response in the TRH test, elevated sex hormone binding globulin (SHBG) levels, and the absence of a family medical history of SITSH or TRβ gene mutations supported the diagnosis of TSH-secreting pituitary adenoma (TSHoma). Read More

    Surgical Management of a Giant Pheochromocytoma.
    In Vivo 2018 May-Jun;32(3):703-706
    Department of Surgery, Division of Surgical Oncology, St. John Hospital & Medical Center, Detroit, MI, U.S.A.
    Pheochromocytomas are rare tumors arising from chromaffin cells of the adrenal medulla and extramedullary sympathetic ganglia. The incidence of asymptomatic disease is rising due to increased detection rates from widespread use of computed tomography. We describe a case of one of the largest documented pheochromocytomas resected in the United States, an 18-cm tumor in a patient who presented with exertional dyspnea, abdominal pain, constipation, weight loss, and intermittent hypertension. Read More

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