Aggregation and phosphorylation of α-synuclein with proteinase K-resistance in focal α-synucleinopathy predominantly localized to the cardiac sympathetic nervous system.
- Nei Fukasawa,
- Takahiro Fukuda,
- Masato Nagaoka,
- Tohru Harada,
- Hiroyuki Takahashi,
- Masahiro Ikegami
Neuropathol Appl Neurobiol 2017 Jun 21. Epub 2017 Jun 21.
Department of Pathology, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.
Aggregates of α-synuclein, a major component of Lewy bodies (LBs) and Lewy neurites (LNs), are distributed throughout the nervous system, including the central nervous system (CNS), sympathetic ganglia, enteric nervous system (ENS), cardiac and pelvic plexuses, submandibular gland, adrenal medulla and skin, in incidental Lewy body disease (ILBD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure (PAF) [1-3]. Here we report focal α-synucleinopathy predominantly localized to the cardiac sympathetic nervous system (SNS). Aggregation and phosphorylation of α-synuclein with proteinase K (PK)-resistance developed predominantly in the cytoplasm and proximal axon of the postganglionic sympathetic neuron (PGSN). Read More