54,679 results match your criteria Adrenal Surgery


Posterior retroperitoneoscopic adrenalectomy for pediatric adrenal tumors.

J Pediatr Surg 2019 Feb 28. Epub 2019 Feb 28.

Department of Paediatric Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899. Electronic address:

Background/aims: Posterior retroperitoneoscoic adrenalectomy has been reported as an option for adrenal tumor resection but is not commonly performed in children owing to the extreme semikneeling position advocated to flatten the lumbar lordosis in order to achieve adequate retroperitoneal space. As children have smaller lordosis angles, flattening of the lordosis and creation of optimal retroperitoneal space may be achieved with less hip flexion. We used pediatric lumbar lordosis measurements to develop a modified prone jackknife position and report our experiences with this setup for posterior retroperitoneoscopic adrenalectomy for adrenal tumors. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.068DOI Listing
February 2019

Comparative assessment of hypothalamic-pituitary-adrenal axis suppression secondary to intrabursal injection of different glucocorticoids: a pilot study.

J Endocrinol Invest 2019 Mar 15. Epub 2019 Mar 15.

Division of Diagnostic and Interventional Radiology, IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Hypothalamic-pituitary-adrenal axis (HPAA) suppression is the most common and dangerous, although often unrecognized and untreated, side effect of glucocorticoid administration. The risk and duration depend both on patient and treatment characteristics. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) currently represents the gold standard method to evaluate the metabolism of endogenous and exogenous steroids. Read More

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http://link.springer.com/10.1007/s40618-019-01033-6
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http://dx.doi.org/10.1007/s40618-019-01033-6DOI Listing
March 2019
1 Read

A rare cause of postpartum acute hyponatremia.

Endocrinol Diabetes Metab Case Rep 2019 Mar 15;2019. Epub 2019 Mar 15.

Department of Internal Medicine F, Soroka University Medical Center, Beer Sheva, Israel.

A previously healthy 24-year-old female underwent an emergent caesarean section without a major bleeding described. During the first post-operative days (POD) she complained of fatigue, headache and a failure to lactate with no specific and conclusive findings on head CT. On the following days, fever rose with a suspicion of an obstetric surgery-related infection, again with no evidence to support the diagnosis. Read More

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http://dx.doi.org/10.1530/EDM-18-0124DOI Listing

COPPS, a composite score integrating pathological features, PS100 and SDHB losses, predicts the risk of metastasis and progression-free survival in pheochromocytomas/paragangliomas.

Virchows Arch 2019 Mar 13. Epub 2019 Mar 13.

Department of Pathology, CHRU de Nancy, Université de Lorraine, F-54000, Nancy, France.

Current histoprognostic parameters and prognostic scores used in paragangliomas and pheochromocytomas do not adequately predict the risk of metastastic progression and survival. Here, using a series of 147 cases of paraganglioma and pheochromocytoma, we designed and evaluated the potential of a new score, the COPPS (COmposite Pheochromocytoma/paraganglioma Prognostic Score), by taking into consideration three clinico-pathological features (including tumor size, necrosis, and vascular invasion), and the losses of PS100 and SDHB immunostain to predict the risk of metastasis. We compared also the performance of the COPPS with several presently used histoprognostic parameters in risk assessment of these tumors. Read More

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http://dx.doi.org/10.1007/s00428-019-02553-5DOI Listing

Adrenal insufficiency in neonates undergoing cardiopulmonary bypass and postoperative hypothalamic-pituitary-adrenal function after prophylactic glucocorticoids.

J Perinatol 2019 Mar 12. Epub 2019 Mar 12.

Division of Critical Care Medicine, Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TX, USA.

Objectives: Determine incidence of preoperative adrenal insufficiency in neonates >35 weeks gestation with congenital heart disease undergoing cardiothoracic surgery with bypass and effects of prophylactic methylprednisolone on postoperative hypothalamic-pituitary-adrenal function and hemodynamic stability.

Design: Prospective observational study in 36 neonates with preoperative adrenocorticotrophic hormone stimulation tests and serial total cortisol and adrenocorticotrophic hormone measurements before and after surgery. Data analyses: analysis of variance and regression. Read More

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http://dx.doi.org/10.1038/s41372-019-0344-7DOI Listing

LARGE ADRENAL INCIDENTALOMAS REQUIRE A DEDICATED DIAGNOSTIC PROCEDURE.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From : Aix Marseille Université, Assistance Publique Hôpitaux de Marseille, Marseille, France.

Introduction: The management of large non secreting adrenal tumors (at least 4 cm) is still a matter of debate as it is unclear whether imaging, especially 18F-FDG, can be used to characterize their potential malignancy. Moreover, the risk of new hypersecretion in non-operated tumors is uncertain. Our aim was to better characterize these large adrenal incidentalomas. Read More

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http://dx.doi.org/10.4158/EP-2018-0616DOI Listing

PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy.

J Clin Endocrinol Metab 2019 Mar 13. Epub 2019 Mar 13.

Hypertension Unit, Department of Medicine -DIMED, University of Medicine of Padova, Padova, Italy.

Context: Accumulating evidences suggest a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored.

Objectives: To test the hypothesis that in vivo Angiotensin (Ang) II blockade affects parathyroid hormone (PTH) secretion in hypertensive patients and that aldosterone and Ang II directly stimulate PTH secretion ex vivo.

Design And Setting: We investigated the changes of serum PTH levels induced by oral captopril (50 mg) administration in patients with primary essential hypertension (EH) and with primary aldosteronism (PA) due to bilateral adrenal hyperplasia (BAH) or to aldosterone-producing adenoma (APA), the latter before and after adrenalectomy. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2019-00143DOI Listing
March 2019
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Improvement in postoperative pain control by combined use of intravenous dexamethasone with intravenous dexmedetomidine after interscalene brachial plexus block for arthroscopic shoulder surgery: A randomised controlled trial.

Eur J Anaesthesiol 2019 Mar 8. Epub 2019 Mar 8.

Ryung A. Kang and Ji S. Jeong contributed equally to the article as first author.

Background: Intravenous dexamethasone or dexmedetomidine is reported to prolong the duration of analgesia after single-shot interscalene brachial plexus block (ISBPB). However, the effect of co-administration of these agents on the duration of analgesia has not been evaluated.

Objectives: We evaluated the difference in time to first rescue analgesic request between patients receiving co-administered intravenous dexamethasone and dexmedetomidine and patients receiving intravenous dexamethasone alone after single-shot ISBPB for arthroscopic shoulder surgery. Read More

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http://dx.doi.org/10.1097/EJA.0000000000000977DOI Listing
March 2019
4 Reads

Sex assignment practice in disorders of sexual differentiation: survey results from paediatric endocrinologists in the Arab region.

J Pediatr Endocrinol Metab 2019 Jan;32(1):75-82

Pediatric Endocrinology Department, Al Qassimi Hospital, Sharjah, UAE.

Background Sex assignment is a major issue in disorders of sexual differentiation (DSD). Not all conditions of DSD have clear recommendations on assignment and timing of surgery. Reports about sex assignment practice and the influence of culture and religion in the Arab region are scarce. Read More

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http://dx.doi.org/10.1515/jpem-2018-0323DOI Listing
January 2019

Intraoperative vasoplegic syndrome in patients with fulminant myocarditis on ventricular assist device placement.

J Anesth 2019 Mar 12. Epub 2019 Mar 12.

Department of Anesthesiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan.

Purpose: Fulminant myocarditis is uncommon, but life-threatening, and some patients need mechanical circulatory support. This study was performed to evaluate how different types of mechanical circulatory support-biventricular assist device (BiVAD) or left ventricular assist device (LVAD) placement-affect intraoperative hemodynamic status.

Methods: From January 2013 to September 2016, the patients who underwent BiVAD or LVAD placement for fulminant myocarditis were analyzed. Read More

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http://dx.doi.org/10.1007/s00540-019-02625-5DOI Listing

The physiological significance of the circadian dynamics of the HPA axis: Interplay between circadian rhythms, allostasis and stress resilience.

Horm Behav 2019 Mar 14;110:77-89. Epub 2019 Mar 14.

Chemical & Biochemical Engineering Department, Rutgers University, Piscataway, NJ, United States of America; Biomedical Engineering Department, Rutgers University, Piscataway, NJ, United States of America; Department of Surgery, Rutgers - Robert Wood Johnson Medical School, New Brunswick, NJ, United States of America. Electronic address:

Circadian time-keeping mechanisms preserve homeostasis by synchronizing internal physiology with predictable variations in the environment and temporally organize the activation of physiological signaling mechanisms to promote survival and optimize the allocation of energetic resources. In this paper, we highlight the importance of the robust circadian dynamics of allostatic mediators, with a focus on the hypothalamic-pituitary-adrenal (HPA) axis, for the optimal regulation of host physiology and in enabling organisms to adequately respond and adapt to physiological stressors. We review studies showing how the chronic disruption of circadian rhythms can result in the accumulation of allostatic load, which impacts the appropriate functioning of physiological systems and diminishes the resilience of internal systems to adequately respond to subsequent stressors. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.018DOI Listing

Erythrocytosis as the first manifestation of adrenal carcinoma.

Pediatr Blood Cancer 2019 Mar 11:e27685. Epub 2019 Mar 11.

G. Martino Hospital, Pediatric Unit, Department of Adulthood and Childhood Human Pathology, University of Messina, Messina, Italy.

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http://dx.doi.org/10.1002/pbc.27685DOI Listing

Investigation of the effects of temporomandibular joint arthrocentesis on blood volume of the retinal structures.

J Dent Anesth Pain Med 2019 Feb 28;19(1):37-44. Epub 2019 Feb 28.

Department of Ophthalmology, Medical School, Adiyaman University, Adiyaman, Turkey.

Objective: Arthrocentesis is a minimally invasive surgical procedure that is used to alleviate the symptoms of temporomandibular joint (TMJ) disorders. The aim of this study was to investigate the effect of arthrocentesis on the blood supply to the retinal structures.

Materials And Methods: Arthrocentesis was performed on 20 patients with TMJ disorders, and choroidal thickness (CT) in patients was measured to evaluate retinal blood circulation. Read More

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http://dx.doi.org/10.17245/jdapm.2019.19.1.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405342PMC
February 2019

Association between stress hormones and perioperative risk in patients with critical limb ischemia undergoing revascularization.

J Vasc Surg 2019 Mar 8. Epub 2019 Mar 8.

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Japan.

Background: It is well known that the clinical outcome of patients with critical limb ischemia (CLI) is poor. However, the relationship between stress-related hormone levels and CLI outcome remains unclear. The aim of this study was to reveal the association of stress hormones with the risk of a perioperative major adverse cardiovascular event (pMACE) in CLI patients undergoing surgical and endovascular revascularization. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.11.044DOI Listing

Concomitant occurrence of primary renal non-Hodgkin lymphoma and a colon cancer: A rare case report.

Medicine (Baltimore) 2019 Mar;98(10):e14802

Department of Pathology.

Rationale: Primary renal lymphoma (PRL) is a rare malignancy due to the absence of lymphatic tissues in the kidney, and patients with PRL have been reported to have a poor prognosis due to its rapid invasiveness and limited treatment strategies. Colon cancer is the third most common cancer, and has a high mortality rate. Both malignant diseases predominantly affected elderly men; however, a case with concomitant occurrence of the 2 cancers is extremely rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000014802DOI Listing

Clinical, Diagnostic, and Treatment Characteristics of -Related Metastatic Pheochromocytoma and Paraganglioma.

Front Oncol 2019 22;9:53. Epub 2019 Feb 22.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Pheochromocytoma and paraganglioma (PHEO/PGL) are rare neuroendocrine tumors which may cause potentially life-threatening complications, with about a third of cases found to harbor specific gene mutations. Thus, early diagnosis, treatment, and meticulous monitoring are of utmost importance. Because of low incidence of succinate dehydrogenase complex subunit A ()-related metastatic PHEO/PGL, currently there exists insufficient clinical information, especially with regards to its diagnostic and treatment characteristics. Read More

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http://dx.doi.org/10.3389/fonc.2019.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395427PMC
February 2019

Occult extra-adrenal pheochromocytoma in the urinary bladder.

BMJ Case Rep 2019 Mar 8;12(3). Epub 2019 Mar 8.

Radiology, Queen Mary Hospital, Hong Kong.

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http://dx.doi.org/10.1136/bcr-2019-229267DOI Listing
March 2019
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Laparoscopic subtotal pancreatectomy with radical antegrade modular pancreatosplenectomy for left-sided pancreatic cancer.

Surg Oncol 2019 Mar 3;28:150. Epub 2019 Jan 3.

Departments of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.

Background: Numerous recent studies have reported comparable oncologic outcomes of laparoscopic distal pancreatectomy for pancreatic cancer compared with open surgery [1,2]. Most of these laparoscopic procedures, however, involved resection for left-sided pancreatic cancer where R0 resection was possible by pancreatic transection around the portal vein-superior mesenteric vein with preservation of the gastroduodenal artery (GDA) [3,4]. Here we describe our technique of laparoscopic subtotal pancreatectomy for pancreatic cancer located in the neck of the pancreas, which requires resection of the GDA and radical antegrade modular pancreatosplenectomy (RAMPS) to achieve a clear resection margin. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.12.006DOI Listing
March 2019
1 Read

Minimally Invasive Surgery for Primary and Metastatic Adrenal Malignancy.

Surg Oncol Clin N Am 2019 04 11;28(2):309-326. Epub 2019 Jan 11.

Department of Surgical Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Since the first description of laparoscopic adrenalectomy (LA) for pheochromocytoma and Cushing syndrome in 1992, the utilization of and indications for a minimally invasive approach to the adrenal gland have vastly expanded. Although minimally invasive adrenalectomy has been established as the preferred approach for patients with benign tumors of the adrenal gland, minimally invasive adrenalectomy for cancer remains controversial. In this article, the authors review the indications for minimally invasive adrenalectomy for adrenal nodules suspicious for, or established to represent, a primary malignancy or a site of metastatic cancer. Read More

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http://dx.doi.org/10.1016/j.soc.2018.11.011DOI Listing
April 2019
1 Read

Case series of testicular adrenal rest tumours in boys with congenital adrenal hyperplasia: A single centre experience.

Med J Malaysia 2019 Feb;74(1):92-93

University Kebangsaan Malaysia Medical Centre, Department of Paediatrics, Kuala Lumpur, Malaysia.

Testicular adrenal rest tumours (TART) are aberrant adrenal tissue within the testes (1). Although benign, they can lead to obstruction of the seminiferous tubules and infertility in patients with congenital adrenal hyperplasia (CAH). We report six boys who developed TART, a complication of CAH. Read More

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February 2019
2 Reads

Long-term outcome of primary bilateral macronodular adrenocortical hyperplasia after unilateral adrenalectomy.

J Clin Endocrinol Metab 2019 Mar 7. Epub 2019 Mar 7.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Germany.

Context: Unilateral adrenalectomy has been proposed in selected patients with primary bilateral macronodular adrenocortical hyperplasia (PBMAH), but its long-term outcome is unclear.

Objective: The aim of this study was to analyze long-term clinical and biochemical outcome of unilateral adrenalectomy versus bilateral adrenalectomy in patients with PBMAH in comparison to outcome of cortisol-producing adenoma (CPA) treated by unilateral adrenalectomy.

Design: Retrospective observational study in three German and one Italian academic tertiary care center. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-02204DOI Listing
March 2019
3 Reads

Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.

Anticancer Res 2019 Mar;39(3):1151-1159

Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland.

Background/aim: Morphological features, combined with Ki-67 proliferative index, remain the standard for discriminating benign and malignant adrenocortical tumors. The aim of this study was to evaluate the role of minichromosome maintenance proteins MCM-3, MCM-5, MCM-7, and Ki-67 as proliferative markers in adrenocortical tumors.

Materials And Methods: Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67. Read More

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http://dx.doi.org/10.21873/anticanres.13224DOI Listing
March 2019
2 Reads

1,000 Retroperitoneoscopic Procedures of the Upper Urinary Tract: Analysis of Complications.

Urol Int 2019 Mar 6:1-7. Epub 2019 Mar 6.

Background And Objective: To evaluate risk factors and complications of retroperitoneoscopic procedures of upper urinary tract and adrenal gland.

Methods: From 1994 to 2016, 1,000 retroperitoneal laparoscopies were performed - 476 nephrectomies, 201 adrenalectomies, 103 partial nephrectomies, 91 pyeloplasties, 70 nephro-ureterectomies, and 59 miscellaneous surgeries (diverticulectomy). Data collection was prospective. Read More

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http://dx.doi.org/10.1159/000497038DOI Listing
March 2019
2 Reads

Clinical utility of routine postoperative morning cortisol monitoring in detecting new hypothalamic-pituitary-adrenal axis insufficiency following endoscopic transsphenoidal surgery for sellar lesions.

J Neurosurg 2019 Mar 1:1-5. Epub 2019 Mar 1.

1Department of Neurological Surgery and.

OBJECTIVEHypothalamic-pituitary-adrenal (HPA) axis dysfunction is a well-documented complication of transsphenoidal craniotomy (TSC) for sellar lesions. The authors aimed to assess their multidisciplinary approach to the diagnosis and treatment of postoperative hypocortisolemia utilizing conservative screening methods.METHODSThe authors performed a retrospective review of 257 patients who underwent TSC for pituitary adenoma (PA) or Rathke cleft cyst (RCC) at the University of Southern California between 2012 and 2017. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182521DOI Listing
March 2019
4 Reads

Red blood cell storage and adhesion to vascular endothelium under normal or stress conditions: an in vitro microfluidic study.

J Trauma Acute Care Surg 2019 Mar 1. Epub 2019 Mar 1.

Michael and Marian Ilitch Department of General Surgery Wayne State University, Detroit, MI.

Introduction: Observational studies have identified an association between duration of red blood cell (RBC) storage and adverse outcomes in trauma. Hemorrhagic shock (HS) leads to impaired tissue perfusion which is associated with endothelial cell (EC) glycocalyx (GC) shedding. Adhesion of stored RBC to the vacular endothelium has been shown to lead to impaired perfusion in the microcirculation and contribute to organ failure and poor outcome. Read More

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http://dx.doi.org/10.1097/TA.0000000000002239DOI Listing
March 2019
3 Reads

Safety of Intradermal/Subcutaneous Lidocaine With Epinephrine Use in Dermatologic Surgery.

Dermatol Surg 2019 Feb 28. Epub 2019 Feb 28.

Dell Medical School, University of Texas at Austin, Austin, Texas.

Background: Recently, the safety of lidocaine plus epinephrine use in outpatient surgery has come under scrutiny despite its long history of use in outpatient dermatologic procedures and surgeries.

Objective: To assess the frequency of crash cart and other emergency interventions during Mohs micrographic surgery when lidocaine plus epinephrine is used as a local anesthetic and evaluate patient comorbidities associated with these events.

Materials And Methods: A retrospective chart review was conducted in an outpatient Mohs micrographic surgery clinic. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001900DOI Listing
February 2019
2 Reads

Primary Adrenal Angiomatoid Fibrous Histiocytoma With Novel EWSR1-ATF1 Gene Fusion Exon-Exon Breakpoint.

Pediatr Dev Pathol 2019 Mar 1:1093526619830287. Epub 2019 Mar 1.

2 Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore.

We describe the clinical, pathological, and molecular features of a primary adrenal angiomatoid fibrous histiocytoma (AFH) in an 11-year-old girl presenting with pyrexia of unknown origin. We performed next-generation sequencing-based anchored multiplex polymerase chain reaction (Archer® FusionPlex® sarcoma assay), which revealed an EWSR1-ATF1 gene fusion with novel breakpoints in exon 11 of EWSR1 and exon 3 of ATF1. The pyrexia resolved fully after surgical resection, and the patient was disease-free on follow-up at 1 year and 6 months. Read More

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http://dx.doi.org/10.1177/1093526619830287DOI Listing
March 2019
3 Reads

Wide-Awake Surgical Management of Hand Fractures: Technical Pearls and Advanced Rehabilitation.

Plast Reconstr Surg 2019 Mar;143(3):800-810

Dayton, Ohio; and Rochester, Minn. From the Department of Orthopedic Surgery, Wright-Patterson Air Force Base; and the Division of Hand Surgery, Department of Orthopedic Surgery, Mayo Clinic.

Most unstable metacarpal and phalangeal fractures for which operative treatment is indicated can be reduced and stabilized with either open or closed techniques using local anesthetic with epinephrine instead of intravenous sedation or general anesthesia. With the patient wide-awake during surgery, the hand can be taken through active range of motion to assess fracture stability. In this article, the authors review the rationale and technique for wide-awake, local anesthesia, no tourniquet surgery in the treatment of phalangeal and metacarpal fractures and impart pearls to optimize the patient experience and illustrate common fixation techniques using percutaneous Kirschner wires. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005379DOI Listing
March 2019
3 Reads

Bronchoscopic cryosurgery for metastatic tumor causing central airway obstruction: A case report.

Medicine (Baltimore) 2019 Mar;98(9):e14635

School of Medicine, National Yang-Ming University, Taipei.

Rationale: Bronchoscopic cryotherapy has been considered as one of the optional interventions for unresectable malignant central airway obstruction (CAO). And it provides high safety and effectiveness in airway patency re-establishment. This report describes the interventional bronchoscopic cryotherapy for a patient with CAO caused by squamous cell carcinoma of the esophagus. Read More

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http://dx.doi.org/10.1097/MD.0000000000014635DOI Listing
March 2019
3 Reads

Exercise Reduces Salivary Morning Cortisol Levels in Patients with Depression.

Mol Neuropsychiatry 2019 Feb 19;4(4):196-203. Epub 2018 Dec 19.

Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Purpose Of The Study: Cortisol hypersecretion plays a role in depression pathophysiology. Internet-based cognitive behavioural therapy (ICBT) and physical exercise (PE) are new treatment alternatives for depression, and their long-lasting effect on cortisol is unknown. We investigated cortisol level changes after 12 weeks of ICBT, PE or treatment as usual (TAU). Read More

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http://dx.doi.org/10.1159/000494699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388436PMC
February 2019
1 Read

A case report on 111In chloride bone marrow scintigraphy in management of adrenal myelolipoma.

Medicine (Baltimore) 2019 Feb;98(8):e14625

Pathology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research.

Rationale: Adrenal myelolipoma is a benign hormone-inactive tumor composed of hematopoietic tissue and mature adipose tissue. Because this tumor tends to be rich in fat, in many cases it can be diagnosed based on computed tomography (CT) or magnetic resonance imaging (MRI) findings alone. However, in the presence of much necrosis, calcification and hematopoietic tissue and/or the absence of much fat, and in cases with tumor apoplexy, this tumor becomes difficult to differentiate from other tumors. Read More

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http://dx.doi.org/10.1097/MD.0000000000014625DOI Listing
February 2019
1 Read

Clinical Outcomes After Unilateral Adrenalectomy for Primary Aldosteronism.

JAMA Surg 2019 Feb 27:e185842. Epub 2019 Feb 27.

Department of Surgical Oncology and Endocrine Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.

Importance: In addition to biochemical cure, clinical benefits after surgery for primary aldosteronism depend on the magnitude of decrease in blood pressure (BP) and use of antihypertensive medications with a subsequent decreased risk of cardiovascular and/or cerebrovascular morbidity and drug-induced adverse effects.

Objective: To evaluate the change in BP and use of antihypertensive medications within an international cohort of patients who recently underwent surgery for primary aldosteronism.

Design, Setting, And Participants: A cohort study was conducted across 16 referral medical centers in Europe, the United States, Canada, and Australia. Read More

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http://dx.doi.org/10.1001/jamasurg.2018.5842DOI Listing
February 2019

Clinical profiles of patients with surgically resected pheochromocytoma and paraganglioma.

Korean J Intern Med 2019 Feb 28. Epub 2019 Feb 28.

Division of Cardiology, Department of Internal Medicine, Chungnam National University College of Medicine, Regional Cardiocerebrovascular Center, Chungnam National University Hospital, Daejeon, Korea.

Background/aims: Pheochromocytoma and paraganglioma (PPGL) are catecholamine-producing tumors that can cause blood pressure (BP) elevation and cardiovascular complications. Clinical presentation of these tumors may be changed through widespread use of imaging studies, which enables detection of PPGLs before onset of symptoms. We investigated clinical profiles of patients with surgically resected PPGLs. Read More

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http://dx.doi.org/10.3904/kjim.2018.231DOI Listing
February 2019
2 Reads

Evaluation of sites of velopharyngeal structure augmentation in dogs for improvement of velopharyngeal insufficiency.

PLoS One 2019 25;14(2):e0212752. Epub 2019 Feb 25.

First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry, Suita City, Osaka, Japan.

Background: Velopharyngeal structure augmentation methods are used as alternatives to velopharyngeal plasty. Anatomic sites of implantation/injection vary widely due to a lack of standardized criteria. Here, we experimentally investigated optimal sites of velopharyngeal structure augmentation via saline injection in dogs as they naturally exhibit velopharyngeal insufficiency (VPI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212752PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388922PMC
February 2019
3 Reads

A unique case of ectopic Cushing's syndrome from a thymic neuroendocrine carcinoma.

Endocrinol Diabetes Metab Case Rep 2019 Feb 22;2019. Epub 2019 Feb 22.

Departments of Endocrinology, Diabetes & Metabolism, Cleveland Clinic, Cleveland, Ohio, USA.

Ectopic adrenocorticotropic hormone (ACTH) production leading to ectopic ACTH syndrome accounts for a small proportion of all Cushing's syndrome (CS) cases. Thymic neuroendocrine tumors are rare neoplasms that may secrete ACTH leading to rapid development of hypercortisolism causing electrolyte and metabolic abnormalities, uncontrolled hypertension and an increased risk for opportunistic infections. We present a unique case of a patient who presented with a mediastinal mass, revealed to be an ACTH-secreting thymic neuroendocrine tumor (NET) causing ectopic CS. Read More

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http://dx.doi.org/10.1530/EDM-19-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391898PMC
February 2019

Intravascular B-large cell lymphoma: an unexpected diagnosis of an incidental adrenal mass.

J Surg Case Rep 2019 Feb 19;2019(2):rjz048. Epub 2019 Feb 19.

Department of Surgery, 5th Surgical Clinic, Evgenidion Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.

Adrenal incidentalomas originally defined as tumors discovered serendipitously in the course of diagnostic evaluation or follow-up of unrelated disorders, may occasionally pose serious diagnostic challenges. Intravascular large B-cell lymphoma (IVLBCL) may be a rare example of such a case. We present an IVLBCL confined to the adrenal gland in a 52-year-old man focusing on its diagnostic and therapeutic aspects. Read More

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http://dx.doi.org/10.1093/jscr/rjz048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380070PMC
February 2019
1 Read

Tissue variations of mosaic genome-wide paternal uniparental disomy and phenotype of multi-syndromal congenital hyperinsulinism.

Eur J Med Genet 2019 Feb 20. Epub 2019 Feb 20.

Odense Pancreas Center (OPAC), Odense University Hospital, Odense, Denmark; Dept. of Pathology, Odense University Hospital, Odense, Denmark; Institute of Clinical Research, University of Southern Denmark Odense, Denmark.

Mosaic genome-wide paternal uniparental disomy (GW-pUPD) is a rarely recognised disorder. The phenotypic manifestations of multilocus imprinting defects (MLIDs) remain unclear. We report of an apparently non-syndromic infant with severe congenital hyperinsulinism (CHI) and diffuse pancreatic labelling by 18F*-DOPA-PET/CT leading to near-total pancreatectomy. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.02.004DOI Listing
February 2019

Iatrogenic adrenal suppression following caudal epidural and facet joint injection.

BMJ Case Rep 2019 Feb 21;12(2). Epub 2019 Feb 21.

Trauma and Orthopaedic Surgery, Whittington Health NHS Trust, London.

Caudal epidural injections and facet joint injections using steroids and local anaesthetic are widely used methods of pain control in patients suffering from radicular leg pain. In the vast majority of cases this is low risk. We present an interesting case of a patient who suffered from symptomatic adrenal suppression following a caudal epidural injection, and thus wish to draw this rare but significant complication to the attention of orthopaedic practitioners. Read More

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http://dx.doi.org/10.1136/bcr-2018-225828DOI Listing
February 2019
2 Reads

Perioperative Anesthetic and Transfusion Management of Veno-Venous Extracorporeal Membrane Oxygenation Patients Undergoing Noncardiac Surgery: A Case Series of 21 Procedures.

J Cardiothorac Vasc Anesth 2019 Jan 24. Epub 2019 Jan 24.

Duke University Medical Center, Department of Anesthesiology, Division of Critical Care, Durham, NC.

Objectives: To analyze the perioperative management of veno-venous extracorporeal membrane oxygenation (VV ECMO) in patients undergoing major noncardiac surgical procedures, which is poorly described in the literature. In doing so, perioperative challenges related to hemodynamic instability, impaired gas exchange, bleeding, and coagulopathy will be quantified.

Design: Retrospective, nonrandomized, observational study. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.055DOI Listing
January 2019
1 Read

Pituitary macroadenoma presenting as severe hyponatremia: a case report.

J Med Case Rep 2019 Feb 23;13(1):40. Epub 2019 Feb 23.

Department of Surgery, Teaching Hospital, Kandy, Sri Lanka.

Background: Hyponatremia is defined as a serum sodium level of less than 135 mEq/L in a patient. Although hyponatremia is not an uncommon laboratory finding, especially in the elderly, hunting for the etiology is a challenging issue for any clinician. The three first-line investigations that are required for further analysis are urine osmolality, serum osmolality, and urinary sodium levels in addition to clinical assessment of volume status. Read More

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http://dx.doi.org/10.1186/s13256-019-2000-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387537PMC
February 2019
2 Reads

Epigoitrin, an Alkaloid From , Reduces H1N1 Infection in Stress-Induced Susceptible Model and .

Front Pharmacol 2019 7;10:78. Epub 2019 Feb 7.

Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou, China.

Stress has been proven to modulate an individual's immune system through the release of pituitary and adrenal hormones such as the catecholamines, growth hormone, and glucocorticoids. These signal molecules can significantly alter the host immune system and make it susceptible to viral infection. In this study, we investigate whether epigoitrin, a natural alkaloid from , provides protection against influenza infection by reducing the host's susceptibility to influenza virus under stress and its underlying mechanism. Read More

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http://dx.doi.org/10.3389/fphar.2019.00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374342PMC
February 2019
2 Reads

Paraganglioma in pregnancy: interdisciplinary management during pregnancy.

Gynecol Endocrinol 2019 Feb 21:1-4. Epub 2019 Feb 21.

a High Complexity Obstetric Unit, Department of Gynecology and Obstetrics , Fundación Valle del Lili , Santiago de Cali , Colombia.

Paragangliomas are tumors that originate from the extra-adrenal neural crest, the incidence of which during pregnancy is not more than two to eight cases per million people per year and are known to be highly morbid. The purpose of this report is to describe the experience and results obtained during management of a primigravida diagnosed with paraganglioma on week 21.2 and received both medical and surgical management with good maternal and perinatal outcomes. Read More

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http://dx.doi.org/10.1080/09513590.2019.1576619DOI Listing
February 2019
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Cardiac Arrest in the Pediatric Cardiac ICU: Is Medical Congenital Heart Disease a Predictor of Survival?

Pediatr Crit Care Med 2019 Mar;20(3):233-242

Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Objectives: Children with medical cardiac disease experience poorer survival to hospital discharge after cardiopulmonary arrest compared with children with surgical cardiac disease. Limited literature exists describing epidemiology and factors associated with mortality in this heterogeneous population. We aim to evaluate the clinical characteristics and outcomes after cardiopulmonary arrest in medical cardiac patients. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001810DOI Listing
March 2019
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Hemodynamic-Directed Cardiopulmonary Resuscitation Improves Neurologic Outcomes and Mitochondrial Function in the Heart and Brain.

Crit Care Med 2019 Mar;47(3):e241-e249

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objectives: Less than half of the thousands of children who suffer in-hospital cardiac arrests annually survive, and neurologic injury is common among survivors. Hemodynamic-directed cardiopulmonary resuscitation improves short-term survival, but its impact on longer term survival and mitochondrial respiration-a potential neurotherapeutic target-remains unknown. The primary objectives of this study were to compare rates of 24-hour survival with favorable neurologic outcome after cardiac arrest treated with hemodynamic-directed cardiopulmonary resuscitation versus standard depth-guided cardiopulmonary resuscitation and to compare brain and heart mitochondrial respiration between groups 24 hours after resuscitation. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003620DOI Listing
March 2019
1 Read

Metamizole inhibits arachidonic acid-induced platelet aggregation after surgery and impairs the effect of aspirin in hospitalized patients.

Eur J Clin Pharmacol 2019 Feb 18. Epub 2019 Feb 18.

Division of Hemostaseology, University Hospital Leipzig, Liebigstr, 20, 04103, Leipzig, Germany.

Purpose: The inhibitory effect of metamizole on platelet aggregation is known for several years, but most studies were conducted in healthy volunteers with contradictory results. Recent studies have shown an inhibitory effect of metamizole on acetylsalicylic acid (ASA)-induced platelet aggregation. We aimed to investigate the effect of metamizole on platelet aggregation after an elective surgery and the effect of metamizole on ASA-induced platelet aggregation in hospitalized patients. Read More

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http://dx.doi.org/10.1007/s00228-019-02646-9DOI Listing
February 2019

The utility of Gallium-DOTATATE PET/CT in the detection of von Hippel-Lindau disease associated tumors.

Eur J Radiol 2019 Mar 22;112:130-135. Epub 2018 Nov 22.

Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia, United States.

Purpose: Patients with von Hippel-Lindau (VHL) disease may develop various tumors, including neuroendocrine tumors of the pancreas (PNETs) and adrenal, central nervous system and retinal hemangioblastomas, kidney tumors and more. Ga-DOTATATE positron emission tomography (PET)/computerized tomography (CT) has been shown to be highly accurate for tumors with cells expressing somatostatin receptors. We aimed to assess the performance of Ga-DOTATATE PET/CT in patients with VHL disease. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.11.023DOI Listing

Epilepsy, depression, and growth hormone.

Epilepsy Behav 2019 Feb 14. Epub 2019 Feb 14.

Clinical and Translational Science Center, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, United States of America.

Depression affects a large proportion of patients with epilepsy, and is likely due in part to biological mechanism. Hormonal dysregulation due to the disruptive effects of seizures and interictal epileptiform discharges on the hypothalamic-pituitary-adrenal axis likely contributes to high rates of depression in epilepsy. This paper reviews the largely unexplored role of neuroendocrine factors in epilepsy-related depression, focusing on Growth Hormone (GH). Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.022DOI Listing
February 2019
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The Value of Histological Algorithms to Predict the Malignancy Potential of Pheochromocytomas and Abdominal Paragangliomas-A Meta-Analysis and Systematic Review of the Literature.

Cancers (Basel) 2019 Feb 15;11(2). Epub 2019 Feb 15.

Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.

Pheochromocytomas (PCCs) and abdominal paragangliomas (PGLs), collectively abbreviated PPGLs, are neuroendocrine tumors of the adrenal medulla and paraganglia, respectively. These tumors exhibit malignant potential but seldom display evidence of metastatic spread, the latter being the only widely accepted evidence of malignancy. To counter this, pre-defined histological algorithms have been suggested to stratify the risk of malignancy: Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and the Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP). Read More

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http://dx.doi.org/10.3390/cancers11020225DOI Listing
February 2019
3 Reads

Buccal Fat Pad Excision: Hydrodissection Technique.

Aesthet Surg J 2019 Feb 15. Epub 2019 Feb 15.

Department of Plastic and Reconstructive Surgery, Hospital General Dr. Ruben Leñero, Mexico City, Mexico.

Background: Buccal fat pad excision is a procedure in which the fat pad is extracted in order to achieve a more youthful appearance.

Objectives: To describe an alternative technique that utilizes hydrodissection as a means to extract the buccal fat pad.

Methods: This is a controlled, prospective, randomized clinical study with two groups. Read More

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http://dx.doi.org/10.1093/asj/sjz040DOI Listing
February 2019
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[A Case of Gastric Neuroendocrine Carcinoma with Bulky Lymph Node Metastases, Solitary Liver Metastasis, and Left Adrenal Metastasis Curatively Resected after Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):103-105

Dept. of Surgery, Osaka City Juso Hospital.

A 68-year-old man presented with generalfatigue due to anemia. Gastrointestinalendoscopy showed a tumor approximately 60mm in diameter in the lesser curvature of the angle of the stomach. Large cell neuroendocrine carcinoma was diagnosed by biopsy of a tumor specimen. Read More

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January 2019
1 Read