Search our Database of Scientific Publications and Authors

I’m looking for a

    53163 results match your criteria Adrenal Surgery

    1 OF 1064

    How ultraviolet light touches the brain and endocrine system through skin, and why.
    Endocrinology 2018 Mar 12. Epub 2018 Mar 12.
    Centre for Dermatology Research, University of Manchester, UK.
    The skin, a self-regulating protective barrier organ, is empowered with sensory and computing capabilities to counteract the environmental stressors to maintain/restore disrupted cutaneous homeostasis. These complex functions are coordinated by a cutaneous neuro-endocrine system that also communicates in a bidirectional fashion with the central nervous, endocrine and immune systems, all acting in concert to control body homeostasis. While ultraviolet energy (UV) has played an important role in the origin and evolution of life, UV absorption by the skin not only triggers mechanisms that defend skin integrity and regulate global homeostasis, but also induces skin pathology (e. Read More

    Adrenal gland hemangioma: A rare case of the incidentaloma: Case report.
    Int J Surg Case Rep 2017 16;41:417-422. Epub 2017 Nov 16.
    Department of Surgery, Military Hospital of Tunis, Tunisia.
    Bakground: Adrenal glands hemangiomas are rare, benign and non-functional tumors. They are often discovered as incidentalomas either during imaging or autopsies. Nearly 70 cases were reported in the literature. Read More

    Ewing sarcoma of the adrenal gland: a case report and review of the literature.
    J Med Case Rep 2018 Mar 16;12(1):69. Epub 2018 Mar 16.
    Radiation Oncology Department, Mohammed VI University Hospital, Marrakech, Morocco.
    Background: Ewing sarcoma/primitive neuroectodermal tumor is a family of highly malignant proliferation of neuroectodermal origin, most often skeletal, adrenal localization is extremely rare. Only few cases have been reported in the literature. Classical management includes radical surgery with adjuvant chemotherapy or radiotherapy or both. Read More

    Excess sodium is deleterious on endothelial and glycocalyx barrier function: A microfluidic study.
    J Trauma Acute Care Surg 2018 Mar 12. Epub 2018 Mar 12.
    Michael and Marian Ilitch Department of Surgery, Wayne State University School of Medicine Detroit, MI 48201, USA.
    Background: Hypernatremia is a common problem affecting critically ill patients, whether due to underlying pathology or the subsequent result of hypertonic fluid resuscitation. Numerous studies have been published suggesting that hypernatremia may adversely affect the vascular endothelial glycocalyx. Our study aimed to evaluate if high sodium concentration would impair the endothelial and glycocalyx barrier function and if stress conditions that simulate the shock microenvironment would exacerbate any observed adverse effects of hypernatremia. Read More

    [Appleby procedure - an option for surgical treatment of pancreatic body tumour infiltrating the celiac axis].
    Magy Seb 2018 Mar;71(1):16-20
    Sebészeti Klinika, Pécsi Tudományegyetem 7624 Pécs, Ifjúság útja 13.
    Case Presentation: After neoadjuvant oncological therapy the surgical treatment of distal pancreatic tumour - infiltrating the celiac axis and the stomach - was reported. During the operation resection of the trunc, distal pancreatectomy, splenectomy, total gastrectomy, resection of the left adrenal gland and cholecystectomy were carried out. The patient's clinical course was uneventful, only transient alteration of liver functions was detected. Read More

    Right adrenal gland pseudocyst masquerading as a large symptomatic hepatic cyst: Single incision laparoscopic (SILS) resection and a review of current literature.
    Ann Hepatobiliary Pancreat Surg 2018 Feb 26;22(1):75-78. Epub 2018 Feb 26.
    Division of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, Department of Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore.
    Adrenal pseudocysts are rare entities, which are usually asymptomatic. Large symptomatic adrenal pseudocysts may cause compressive symptoms. The etiology of these cysts is unknown, although the cyst wall is all lined by fibrous tissue, without any epithelial or endothelial lining. Read More

    18F-FDOPA PET/CT imaging of MAX-related pheochromocytoma.
    J Clin Endocrinol Metab 2018 Mar 8. Epub 2018 Mar 8.
    Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA.
    Context: MYC associated factor X (MAX) has been recently described as a new susceptibility pheochromocytoma (PHEO) gene with a total of approximately 40 reported cases. At present, no study has specifically described the functional imaging phenotype of MAX-related PHEO.

    Objective, Patients, And Design: The objective of this study was to present our experience with contrast-enhanced CT and 18F-FDOPA PET/CT imaging in 6 consecutive patients (4 at initial diagnosis and 2 at follow-up evaluation) with rare but clinically important MAX-related PHEOs. Read More

    Pure Laparoscopic Right Hepatectomy Using Modified Liver Hanging Maneuver: Technical Evolution from Caudal Approach Toward Ventral Approach.
    J Gastrointest Surg 2018 Mar 12. Epub 2018 Mar 12.
    Department of Surgery, Eulji University College of Medicine, Daejeon, Republic of Korea.
    Background: The liver hanging maneuver during right hepatectomy is a useful technique for parenchymal transection. The laparoscopic caudal approach is totally different from the laparoscopic ventral approach because of the direction of parenchymal transection. There are differences in the application and effectiveness of liver hanging maneuver between two approaches. Read More

    Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c-fos in the hypothalamus and medulla oblongata: Anaphylaxis affects the brain and activates sympathetic nerves.
    Exp Physiol 2018 Mar 10. Epub 2018 Mar 10.
    Department of Physiology II, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.
    New Findings: What is the central question of this study? Whether anaphylaxis affects sympathetic outflows to the brown adipose tissue (BAT) and adrenal grand is not known. Moreover, it is unknown whether anaphylaxis affects some brain areas in association with sympathetic regulation. What is the main finding and its importance? We showed that sympathoexcitatory responses to anaphylaxis regionally occurred in the kidney and adrenal grand, but not in the thermogenesis-related BAT. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Management of Cushing's syndrome during Pregnancy: solved and unsolved questions.
    Eur J Endocrinol 2018 Mar 9. Epub 2018 Mar 9.
    F Castinetti, Department of endocrinology, Aix-Marseille université, Assistance-Publique-Hôpitaux de Marseille, centre de référence des maladies rares d'origine hypophysaire, Marseille, 13005, France.
    With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2-3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. Read More

    Visual quality assessment of the liver graft by the transplanting surgeon predicts postreperfusion syndrome after liver transplantation: a retrospective cohort study.
    BMC Anesthesiol 2018 Mar 9;18(1):29. Epub 2018 Mar 9.
    Department of Anaesthesiology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
    Background: The discrepancy between demand and supply for liver transplants (LT) has led to an increased transplantation of organs from extended criteria donors (ECD).

    Methods: In this single center retrospective analysis of 122 cadaveric LT recipients, we investigated predictors of postreperfusion syndrome (PRS) including transplant liver quality categorized by both histological assessment of steatosis and subjective visual assessment by the transplanting surgeon using multivariable regression analysis. Furthermore, we describe the relevance of PRS during the intraoperative and postoperative course of LT recipients. Read More

    Surgery for pheochromocytoma: A 20-year experience of a single institution.
    Hormones (Athens) 2017 Oct;16(4):388-395
    Third Department of Surgery, Athens General Hospital "G. Gennimatas", Greece.
    Objective: Resection of pheochromocytomas is a challenging procedure due to hemodynamic lability. Our aim was to evaluate surgical outcomes in 67 patients with pheochromocytoma and to validate the role of laparoscopic surgery in the treatment of these tumors.

    Design: This study is a retrospective review. Read More

    Single Center Experience of a New Endoscopic Clip in Managing Nonvariceal Upper Gastrointestinal Bleeding.
    J Clin Gastroenterol 2018 Apr;52(4):307-312
    Division of Digestive Diseases, Mount Sinai Beth Israel Hospital, New York, NY.
    Background: To assess the safety and efficacy of the Instinct clip in the acute endoscopic treatment of upper gastrointestinal bleeding (UGIB).

    Materials And Methods: This is the first large series reporting this clip in achieving hemostasis. A retrospective descriptive chart review was performed on patients presenting with recent overt GI bleeding treated with endoclip therapy at Mount Sinai Beth Israel Medical Center between May 2013 and January 2016. Read More

    Time-dependent change in relapse sites of renal cell carcinoma after curative surgery.
    Clin Exp Metastasis 2018 Mar 7. Epub 2018 Mar 7.
    Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    We investigated time-dependent changes in the relapse features of renal cell carcinoma (RCC) after curative surgery. Between 1985 and 2015, 1398 patients with RCC (1226 clear cell RCC, 89 papillary RCC, and 53 chromophobe RCC) underwent curative surgery at Yokohama City University Hospital and its affiliated hospitals. We retrospectively reviewed the clinicopathologic factors of patients with relapse after surgery. Read More

    Acute Primary Adrenal Insufficiency after Hip Replacement in a Patient with Acute Intermittent Porphyria.
    Case Rep Endocrinol 2018 4;2018:2353172. Epub 2018 Jan 4.
    Division of Endocrinology, Diabetology and Metabolism, Santa Croce e Carle Hospital, Via M. Coppino 26, 12100 Cuneo, Italy.
    Adrenal insufficiency is a potentially life-threatening condition when it occurs acutely, as in adrenal hemorrhage. Generally it is not reversible and requires chronic replacement therapy. Acute intermittent porphyria (AIP) is a rare genetic disease characterized by alterations in heme biosynthesis that result in accumulation of precursors in tissues. Read More

    A rare mediastinal occurrence of neuroblastoma in an adult: case report.
    Sao Paulo Med J 2018 Mar 5. Epub 2018 Mar 5.
    MD. Professor, Department of Thoracic Surgery, Trakya Üniversitesi Tip Fakültesi, Edirne, Turkey.
    Context: Neuroblastoma is the most common extracranial malignant solid tumor that occurs during childhood. It arises from primitive cells and is seen in the adrenal medulla and sympathetic ganglia of the sympathetic nervous system.

    Case Report: We present a rare case of a 40-year-old man who was diagnosed with the onset of neuroblastoma arising in the mediastinum. Read More

    Targeted treatment of primary aldosteronism - The consensus of Taiwan Society of Aldosteronism.
    J Formos Med Assoc 2018 Mar 2. Epub 2018 Mar 2.
    Division of Cardiology, National Taiwan University Hospital, Taipei, Taiwan.
    Background/purpose: Even with the increasing recognition of primary aldosteronism (PA) as a cause of refractory hypertension and an issue of public health, the consensus of its optimal surgical or medical treatment in Taiwan has not been reached. Our objective was to develop a clinical practice guideline that is feasible for real-world management of PA patients in Taiwan.

    Methods: The Taiwan Society of Aldosteronism (TSA) Task Force recognized the above-mentioned issues and reached this Taiwan PA consensus at its inaugural meeting, in order to provide updated information of internationally acceptable standards, and also to incorporate our local disease characteristics and constraints into PA management. Read More

    A case of adrenocortical carcinoma accompanying secondary acute adrenal hypofunction postoperation.
    World J Surg Oncol 2018 Mar 5;16(1):43. Epub 2018 Mar 5.
    Department of Hepatobiliary and Pancreatic Surgery, Bethune Hospital 1, Changchun, Jilin, 130021, China.
    Background: Adrenocortical carcinoma (ACC) is a rare, heterogeneous malignancy with a poor prognosis. ACCs are classified as functioning and non-functioning. The pathogenesis of ACC remains elusive, and diagnosis of ACC is currently based on pathology. Read More

    Characteristics of Female Genital Restoration Surgery for Congenital Adrenal Hyperplasia Using a Large Scale Administrative Database.
    Urology 2018 Mar 2. Epub 2018 Mar 2.
    Department of Urology, Section of Pediatric Urology, Riley Hospital for Children at IU Health, 702 Barnhill Drive, Suite 4230, Indianapolis, IN 46202, USA.
    Objectives: To analyze nationwide information on the timing of surgical procedures, cost of surgery, hospital length of stay following surgery and surgical complications of female genital restoration surgery (FGRS) in females with congenital adrenal hyperplasia (CAH).

    Methods: We used the Pediatric Health Information System database to identify patients with CAH who underwent their initial FGRS in 2004-2014. These patients were identified by an ICD-9 diagnosis code for adrenogenital disorders (255. Read More

    Clinically suspected anaphylaxis induced by sugammadex in a patient with Weaver syndrome undergoing restrictive mammoplasty surgery: A case report with the literature review.
    Medicine (Baltimore) 2018 Jan;97(3):e9661
    Rationale: Sugammadex is a cylodextrin derivate that encapsulates steroidal neuromuscular blocker agents and is reported as a safe and well-tolerated drug. In this case report, we present a patient who developed grade 3 anaphylaxis just after sugammadex administration.

    Patient Concerns: A 22-year-old woman with diagnosis of Weaver syndrome was scheduled for bilateral mammoplasty and resection of unilateral accessory breast tissue resection. Read More

    Effect of warming anesthetic on pain perception during dental injection: a split-mouth randomized clinical trial.
    Local Reg Anesth 2018 22;11:9-13. Epub 2018 Feb 22.
    Department of Center for Interdisciplinary Studies on Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile.
    Background: The purpose of this study is to determine the effectiveness of warming anesthesia on the control of the pain produced during the administration of dental anesthesia injection and to analyze the role of Transient Receptor Potential Vanilloid-1 nociceptor channels in this effect.

    Patients And Methods: A double-blind, split-mouth randomized clinical trial was designed. Seventy-two volunteer students (22. Read More

    Plurihormonal ACTH-GH pituitary adenoma: case report and systematic literature review.
    World Neurosurg 2018 Feb 28. Epub 2018 Feb 28.
    Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia - Brescia, Italy. Electronic address:
    Introduction: Plurihormonal adenomas (PHA) represent 10-15% of all functioning pituitary adenomas. The most frequent hormonal association is represented by prolactin and growth hormone (GH).

    Aim: To describe a rare case of functional ACTH and GH microadenoma, together with a systematic literature review on PHA. Read More

    Is surgical antibiotic prophylaxis necessary for pediatric orchiopexy?
    J Pediatr Urol 2018 Feb 21. Epub 2018 Feb 21.
    Center for Pediatric and Adolescent Comparative Effectiveness Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
    Introduction: Surgeons frequently use surgical antibiotic prophylaxis (SAP), despite limited evidence to support its efficacy. Potential adverse events associated with antibiotic use include allergic reaction (including anaphylaxis), Clostridium difficile infection, and selecting for resistant bacteria. Surgical site infections (SSI) are very rare in patients undergoing clean pediatric urologic procedures. Read More

    Two-stage resection of a bilateral pheochromocytoma and pancreatic neuroendocrine tumor in a patient with von Hippel-Lindau disease: A case report.
    Int J Surg Case Rep 2018 Feb 16;44:139-142. Epub 2018 Feb 16.
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
    Introduction: von Hippel-Lindau disease (vHL disease) is a hereditary disease in which tumors and cysts develop in many organs, in association with central nervous system hemangioblastomas, pheochromocytomas, and pancreatic tumors. We herein report a case of vHL disease (type 2A) associated with bilateral pheochromocytomas, pancreatic neuroendocrine tumors (PNET), and cerebellar hemangioblastomas treated via pancreatectomy after adrenalectomy.

    Case Presentation: A 51-year-old woman presented with a cerebellar tumor, bilateral hypernephroma, and pancreatic tumor detected during a medical checkup. Read More

    Injection Therapies for Rotator Cuff Disease.
    Orthop Clin North Am 2018 Apr 19;49(2):231-239. Epub 2017 Dec 19.
    Sports Medicine and Shoulder Service, Hospital for Special Surgery, 535 East 70th Street, New York, NY, USA.
    Rotator cuff disease affects a large proportion of the overall population and encompasses a wide spectrum of pathologies, including subacromial impingement, rotator cuff tendinopathy or tear, and calcific tendinitis. Various injection therapies have been used for the treatment of rotator cuff disease, including corticosteroid, prolotherapy, platelet-rich plasma, stem cells, and ultrasound-guided barbotage for calcific tendinitis. However, the existing evidence for these therapies remains controversial or sparse. Read More

    A black adrenal adenoma with high FDG uptake on PET/CT scan in a patient with esophageal carcinoma: A case report.
    Int J Surg Case Rep 2017 Dec 7;44:118-121. Epub 2017 Dec 7.
    Department of Surgery, Jichi Medical University, Tochigi, Japan.
    Introduction: Black adrenal adenoma (BAA) is a rare, benign adrenal lesion with a black or brown appearance. This is the first report of this lesion in a patient with a synchronous esophageal cancer and highlights the importance of considering a false positive finding on a Positron Emission Tomography (PET) scan, which might otherwise preclude resection.

    Presentation Of Case: A 73-year-old male was diagnosed with mid-esophagus carcinoma. Read More

    Endocr Pract 2018 Mar 2. Epub 2018 Mar 2.
    Endocrine and Metabolic Unit, Royal Adelaide Hospital and University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia.
    Background: Glucocorticoid pharmacotherapy is an effective treatment for a range of diseases but exposure can cause suppression of the HPA axis, leading to glucocorticoid-induced adrenal insufficiency (GC-AI) in some patients. However, the incidence of diagnosed GC-AI and the health burden it imposes on patients, including the incidence of adrenal crises (ACs), are unknown. Although, treatment of GC-AI is based on well-established principles, there are no agreed protocols on the perioperative management of exposed patients. Read More

    Optimizing Hemodynamics with Transcatheter Arterial Embolization in Adrenal Pheochromocytoma Rupture: A Case Report.
    Intern Med 2018 Feb 28. Epub 2018 Feb 28.
    Department of Internal Medicine, Teikyo University School of Medicine, Japan.
    Pheochromocytoma rupture is rare, and emergent adrenalectomy is associated with a high mortality. We herein report a patient with pheochromocytoma rupture who was stabilized by transcatheter arterial embolization (TAE) and subsequently underwent elective surgery. A 45-year-old man presented with the sudden onset of left lateral abdominal pain, headache, chest discomfort, high blood pressure, and adrenal hemorrhaging on enhanced abdominal computed tomography. Read More

    Health status in 1040 adults with disorders of sex development (DSD): a European multicenter study.
    Endocr Connect 2018 Feb 28. Epub 2018 Feb 28.
    B Koehler, Institute of Experimental Pediatric Endocrinology, Charite, Berlin, 13353, Germany.
    Objective: The knowledge about health status in adults with disorder of sex development (DSD) is scarce.

    Design And Methods: A cross-sectional observational study in 14 European tertiary centers recruited 1040 participants (717 females, 311 males, 12 others) with DSD. Mean age was 32. Read More

    Pheochromocytoma diagnosed during pregnancy: lessons learned from a series of ten patients.
    Surg Endosc 2018 Feb 27. Epub 2018 Feb 27.
    Department of Endocrine Surgery, Ukrainian Scientific and Practical Center for Endocrine Surgery of Public Health Ministry of Ukraine, Kiev, Ukraine.
    Background: Pheochromocytoma (PHEO) in pregnancy is a life-threatening condition. Its management is challenging with regards to the timing and type of surgery.

    Methods: A retrospective review of the management of ten patients diagnosed with pheochromocytoma during pregnancy was performed. Read More

    Arterial supply to the rabbit adrenal gland.
    Anat Sci Int 2018 Feb 27. Epub 2018 Feb 27.
    Laboratory of Veterinary Anatomy, Faculty and Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, 183-8509, Japan.
    The adrenal gland regulates stress responses by releasing steroid hormones, whose synthesis and secretion are influenced by adrenal blood flow. Adrenalectomy is commonly performed in rabbits to study the function of the adrenal gland. Although knowledge of the arterial supply to the adrenal gland forms the anatomical basis of the surgery, its description in prior studies is incomplete for the rabbit. Read More

    Managing a Large-Size Adrenal Cyst by Hand-Assisted Laparoscopic Surgery in a Young Male.
    J Coll Physicians Surg Pak 2018 Mar;28(3):S28-S30
    Department of Urology and Kidney Transplant, Pakistan Kidney Institute, Shifa International Hospital, Islamabad.
    Adrenal cysts are not common and are most often non-functional and asymptomatic. Most of these cysts are found incidentally. These lesions exhibit a broad histomorphologic spectrum and may vary from benign cysts to malignant cystic neoplasms. Read More

    Intraoperative Nerve Blocks Fail to Improve Quality of Recovery after Tissue Expander Breast Reconstruction: A Prospective, Double-Blinded, Randomized, Placebo-Controlled Clinical Trial.
    Plast Reconstr Surg 2018 Mar;141(3):590-597
    Chicago, Ill. From the Division of Plastic Surgery and the Department of Anesthesiology, Northwestern University Feinberg School of Medicine.
    Background: The authors' study represents the first level I evidence to assess whether intraoperative nerve blocks improve the quality of recovery from immediate tissue expander/implant breast reconstruction.

    Methods: A prospective, randomized, double-blinded, placebo-controlled clinical trial was conducted in which patients undergoing immediate tissue expander/implant breast reconstruction were randomized to either (1) intraoperative intercostal and pectoral nerve blocks with 0.25% bupivacaine with 1:200,000 epinephrine and 4 mg of dexamethasone or (2) sham nerve blocks with normal saline. Read More

    Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure.
    Acta Anaesthesiol Scand 2018 Apr 25;62(4):420-450. Epub 2018 Feb 25.
    Department of Intensive Care 4131, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
    Background: Adult critically ill patients often suffer from acute circulatory failure and those with low cardiac output may be treated with inotropic agents. The aim of this Scandinavian Society of Anaesthesiology and Intensive Care Medicine guideline was to present patient-important treatment recommendations on this topic.

    Methods: This guideline was developed according to GRADE. Read More

    Comparison of Cytotoxic Effects of Intra-Articular Use of Tranexamic Acid versus Epinephrine on Rat Cartilage.
    Med Sci Monit 2018 Feb 25;24:1166-1170. Epub 2018 Feb 25.
    Department of Orthopedics and Traumatology, Bezmialem Vakif University, Istanbul, Turkey.
    BACKGROUND Adequate visualization is known to be essential to perform arthroscopic procedures effectively and efficiently. We hypothesized that tranexamic acid may be considered as an alternative agent to reduce intra-articular bleeding during arthroscopic procedures, after comparing its potential chondrotoxicity with that of epinephrine. MATERIAL AND METHODS Seventy-two rats were randomized into 3 groups with 24 rats each. Read More

    Permanent Hypoparathyroidism After Total Thyroidectomy in Children: Results from a National Registry.
    World J Surg 2018 Feb 22. Epub 2018 Feb 22.
    Department of Clinical Science, Lund University, 221 85, Lund, Sweden.
    Introduction: Hypoparathyroidism is the most common complication following thyroidectomy. There are few population-based reports on the rate of hypoparathyroidism in children. The incidence of medical treatment of permanent hypoparathyroidism in children is reported using a national registry. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Can we cure Cushing's disease ?
    Eur J Endocrinol 2018 Feb 21. Epub 2018 Feb 21.
    X Bertagna, Endocrinologie, Hopital Cochin, Paris, 75014, France
    One of today's challenges in endocrinology is the treatment of Cushing's disease: Whereas pituitary surgery has the potential to "cure" the patient and restore a completely normal pituitary adrenal axis, there are immediate failures and late recurrences that will ultimately require alternate therapeutic approaches. Their high number is in direct correlation with their serious limitations and they all appear to be "default options". This "personal view" tries to shed some light on the inescapable difficulties of the current treatments of Cushing's disease, and to provide some optimistic view for the future where the pituitary adenoma should be the "reasonable obsession" of a successful therapeutist…. Read More

    Application of strict criteria in adrenal venous sampling increases the proportion of missed patients with unilateral disease who benefit from surgery for primary aldosteronism.
    J Hypertens 2018 Feb 20. Epub 2018 Feb 20.
    Department of Surgery, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
    Objectives: Adrenal vein sampling (AVS) is intended to confirm unilateral forms of primary aldosteronism, which are amenable to surgical cure. Excessively strict AVS criteria to define lateralization may result in many patients incorrectly categorized as bilateral primary aldosteronism and opportunity for surgical cure missed.

    Methods: Retrospective review of an AVS-primary aldosteronism database in which surgical cases are verified by standardized outcomes. Read More

    Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan's syndrome?
    Minerva Endocrinol 2018 Feb 19. Epub 2018 Feb 19.
    Department of Neurosurgery, University of Tübingen, Tübingen, Germany.
    Pregnancy-related hypophysitis (PR-Hy) that typically occurs during late pregnancy and the early postpartum period is considered an autoimmune disorder. Knowledge and awareness of characteristic clinical symptoms and specific endocrine and neuroradiological features mostly enables a correct diagnosis and guarantees best possible management. In the presence of mild clinical symptoms, a "wait and watch" policy is recommended. Read More

    Low-Dose Epinephrine Plus Tranexamic Acid Reduces Early Postoperative Blood Loss and Inflammatory Response: A Randomized Controlled Trial.
    J Bone Joint Surg Am 2018 Feb;100(4):295-304
    Center for Joint Surgery (W.-N.Z., J.-L.L., F.-Y.W., C.C., and L.Y.) and Department of Orthopaedic Surgery (W.-N.Z. and Q.Z.), Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China.
    Background: The reductions of perioperative blood loss and inflammatory response are important in total knee arthroplasty. Tranexamic acid reduced blood loss and the inflammatory response in several studies. However, the effect of epinephrine administration plus tranexamic acid has not been intensively investigated, to our knowledge. Read More

    Georgian Med News 2018 Jan(274):19-24
    Medical Center "MediClubGeorgia" Tbilisi; Pathology Research Center, Tbilisi, Georgia.
    Adrenocortical carcinoma is a very rare and aggressive endocrinological malignancy arising from the adrenal cortex. The estimated incidence is 1 per million people, with an estimated 5-year survival rate of 16-47%. It can be bilateral in roughly 2-10% of cases, but the data is scarce and there is no conclusive evidence whether the contralateral mass is an independent tumor or a metastasis from the other adrenal gland cancer. Read More

    Para-ovarian adrenal rest tumors: gynecologic manifestations of untreated congenital adrenal hyperplasia.
    Gynecol Endocrinol 2018 Feb 20:1-3. Epub 2018 Feb 20.
    d Department of Gynecology Oncology , University of California Irvine , Orange , CA , USA.
    Congenital adrenal hyperplasia (CAH) is an inherited disorder of adrenal steroidogenesis often diagnosed in infancy. Gynecologists may encounter adult patients with CAH due to the clinical effects of increased androgens, e.g. Read More

    The importance of standardisation of measurement and reference intervals for detection of phaeochromocytoma and paraganglioma (PPGL).
    Ir J Med Sci 2018 Feb 19. Epub 2018 Feb 19.
    Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, Galway, Ireland.
    A 51-year-old male presented 25 years ago with excessive sweating and haematuria. Blood pressure was labile. CT abdomen showed a large right-sided adrenal mass. Read More

    [Pheochromocytoma giant cystic: a case report].
    Rev Gastroenterol Peru 2017 Oct-Dec;37(4):374-378
    Servicio de Cirugía General, Clínica San Felipe. Lima, Perú.
    The giant cystic pheochromocytoma is a rare adrenal tumor in the predominantly asymptomatic course; so many cases are not diagnosed until the time of surgery. The simple mobilization of the tumor is associated with the passage to the blood of large amounts of catecholamines and high morbidity and mortality. So the surgery itself and perioperative management are a huge challenge. Read More

    The effect of time of day testing and utility of 30 and 60 minute cortisol values in the 250 mcg ACTH stimulation test.
    Clin Biochem 2018 Feb 16. Epub 2018 Feb 16.
    Division of Endocrinology, Department of Medicine, Dalhousie University, Halifax, NS, Canada. Electronic address:
    Background: Despite widespread use of the 250-mcg Cosyntropin test (ACTH test) for the diagnosis of adrenal insufficiency (AI), the effect of time of day and the utility of performing both 30- and 60-min serum cortisol values remains unclear.

    Methods: We conducted a retrospective cohort study of all ACTH testing at the Halifax Neuropituitary Program, Nova Scotia, Canada between January 2006 and April 2016. Data were collected on age, gender, medication history, serum cortisol levels at 0, 30 and 60 min after ACTH administration, as well as time of and indication for testing. Read More

    Multiple endocrine neoplasia 2A (MEN 2A) syndrome.
    Bratisl Lek Listy 2018 ;119(2):120-125
    Introduction: In the MEN 2A syndrome, which is the most common of the three types of MEN, three endocrine systems are affected simultaneously or subsequently by the development of tumours manifested by medullary thyroid gland carcinoma, pheochromocytoma (often bilateral) and hyperparathyroidism.

    Material And Methods: 27 patients from 3 families affected by MEN 2A syndrome were examined clinically (by detecting the effects of catecholamine overproduction), biochemically (screening for metanephrine and normetanephrine in the serum), visualization (CT, MRI, MIBG, PET CT) and some of them also genetically (DNA fragment analysis obtained by PCR amplification).

    Results: Familial incidence of pheochromocytoma was confirmed in 10 patients (4 males, 5 females and one girl) aged 6 to 54 years (average 22. Read More

    A Potential Mechanism for Immune Suppression by Beta-Adrenergic Receptor Stimulation following Traumatic Injury.
    J Innate Immun 2018 Feb 16. Epub 2018 Feb 16.
    Harborview Injury Prevention and Research Center, Department of Surgery, University of Washington, Seattle, Washington, USA.
    Background: β-Adrenergic agents suppress inflammation and may play an important role in posttraumatic infections. Mechanisms may include inhibition of MAP kinase signaling. We sought to determine whether MKP-1 contributed to catecholamine suppression of innate immunity and also wanted to know whether early catecholamine treatment after traumatic injury increases the risk of later nosocomial infection. Read More

    A short review of primary aldosteronism in a question and answer fashion.
    Endocr Regul 2018 Jan;52(1):27-40
    5Resident Surgeon, 3rd Department of Surgery, Attikon University Hospital, University of Athens School of Medicine , Athens , Greece.
    Objectives: The aim of this study was to present up to date information concerning the diagnosis and treatment of primary aldosteronism (PA). PA is the most common cause of endocrine hypertension. It has been reported up to 24% of selective referred hypertensive patients. Read More

    1 OF 1064