J Integr Med 2021 May 28. Epub 2021 May 28.
Laboratory of Medical Investigation (LIM-26), Department of Surgery, University of Sao Paulo Medical School, São Paulo, SP 01246903, Brazil; Program in Anesthesiology, Surgical Sciences, and Perioperative Medicine, University of São Paulo, São Paulo, SP 01246903, Brazil; Brazilian Academic Consortium for Integrative Health (CABSIN), Natural Products Committee, São Paulo, SP 05449-070, Brazil. Electronic address:
Objective: To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics, yeast β-glucans, minerals and silymarin (Silybum marianum), on lipid and glycidic metabolism, inflammatory and mitochondrial proteins of the liver, in control and high-fat diet-induced obese mice.
Methods: After an acclimation period, 32 male C57BL/6 mice were divided into the following groups: nonfat diet (NFD) vehicle, NFD supplemented, high-fat diet (HFD) vehicle and HFD supplemented. The vehicle and experimental formulation were administered orally by gavage once a day during the last four weeks of the diet (28 consecutive days). Read More