5,452 results match your criteria Adrenal Metastases


[A Case of Gastric Neuroendocrine Carcinoma with Bulky Lymph Node Metastases, Solitary Liver Metastasis, and Left Adrenal Metastasis Curatively Resected after Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):103-105

Dept. of Surgery, Osaka City Juso Hospital.

A 68-year-old man presented with generalfatigue due to anemia. Gastrointestinalendoscopy showed a tumor approximately 60mm in diameter in the lesser curvature of the angle of the stomach. Large cell neuroendocrine carcinoma was diagnosed by biopsy of a tumor specimen. Read More

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January 2019

[Gastric Neuroendocrine Carcinoma(NEC)Treated with CDDP plus CPT-11 Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):65-69

Dept. of Digestive Surgery, Saku Central Hospital Advanced Care Center.

A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Read More

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January 2019
2 Reads

Imaging features of SMARCA4-deficient thoracic sarcomas: a multi-centric study of 21 patients.

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Center, 229, cours de l'Argonne, F-33000, Bordeaux, France.

Objectives: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS.

Methods: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. Read More

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http://dx.doi.org/10.1007/s00330-019-06017-xDOI Listing
February 2019
1 Read

Long-term survival of a patient with a large adrenal primitive neuroectodermal tumor: A case report.

World J Clin Cases 2019 Feb;7(3):340-346

Department of Urology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200025, China.

Background: Adrenal primitive neuroectodermal tumor (PNET) is an extremely rare malignant tumor with poor prognosis and of neural crest origin. Herein, we report a case of adrenal PNET and summarized its clinical and pathological characteristics on the basis of 16 patients reported recently.

Case Summary: A female patient aged 25 years presented with right lumbago for 12 mo, and pre-operative computed tomography showed a huge right adrenal mass. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i3.340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369397PMC
February 2019

Unusual Metastases in Papillary Microcarcinoma of Thyroid.

Indian J Nucl Med 2019 Jan-Mar;34(1):32-34

Department of Nuclear Medicine, SVIMS, Tirupati, Andhra Pradesh, India.

Papillary carcinoma thyroid is the most common type of thyroid cancer. Papillary thyroid cancer metastasizes commonly to regional lymph nodes, distant organ involvement is to lungs and bone are rare and is associated with poor prognosis. Metastases to intra-abdominal organs are extremely rare. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_127_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352647PMC
February 2019
1 Read

A Rare Presentation of Colorectal Cancer with Unusual Progressive Intramuscular and Subcutaneous Metastatic Spread.

Asia Ocean J Nucl Med Biol 2019 ;7(1):89-94

Tabriz University of Medical Sciences, Tabriz, Iran.

Colorectal carcinoma is one of the most common causes of cancer-related death, worldwide. Recently, due to the introduction of novel imaging and therapeutic techniques, five-year survival of patients has increased. However, distant metastasis is still expected in half of the patients. Read More

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http://dx.doi.org/10.22038/AOJNMB.2018.11934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352049PMC
January 2019
1 Read

Management of primary retroperitoneal synovial sarcoma: A case report and review of literature.

World J Gastrointest Surg 2019 Jan;11(1):27-33

4 Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Chaidari, Athens 12462, Greece.

Background: Synovial sarcoma (SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the extremities. Nevertheless, several cases of retroperitoneal SS (RSS) have been described. We herein report a case of RSS presented in our institution. Read More

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http://dx.doi.org/10.4240/wjgs.v11.i1.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354068PMC
January 2019
1 Read

Renal and adrenal masses containing fat at MRI: Proposed nomenclature by the society of abdominal radiology disease-focused panel on renal cell carcinoma.

J Magn Reson Imaging 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

This article proposes a consensus nomenclature for fat-containing renal and adrenal masses at MRI to reduce variability, improve understanding, and enhance communication when describing imaging findings. The MRI appearance of "macroscopic fat" occurs due to a sufficient number of aggregated adipocytes and results in one or more of: 1) intratumoral signal intensity (SI) loss using fat-suppression techniques, or 2) chemical shift artifact of the second kind causing linear or curvilinear India-ink (etching) artifact within or at the periphery of a mass at macroscopic fat-water interfaces. "Macroscopic fat" is most commonly observed in adrenal myelolipoma and renal angiomyolipoma (AML) and only rarely encountered in other adrenal cortical tumors and renal cell carcinomas (RCC). Read More

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http://dx.doi.org/10.1002/jmri.26542DOI Listing
January 2019
2 Reads

[A Patient with Multiple Pancreatic Metastases Undergoing Total Pancreatectomy 18 Years after Renal Cell Carcinoma Resection].

Gan To Kagaku Ryoho 2018 Dec;45(13):2214-2216

Dept. of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine.

A 71-year-old woman underwent right nephrectomy for the treatment of clear cell renal cell carcinoma at the age of 53. After 15 years, surgical removal of a solitary tumor was performed in the right adrenal gland and thyroid gland; both were diagnosed as metastases of renal cell carcinoma. Eighteen years after the initial resection, computed tomography(CT) showed multiple hypervascular tumors spreading across the entire area of the pancreas. Read More

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December 2018
1 Read

Pleural dedifferentiated liposarcoma: A case report.

Mol Clin Oncol 2019 Jan 5;10(1):132-136. Epub 2018 Nov 5.

Department of Pathology, Japan Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan.

The present case report describes a rare case of pleural liposarcoma. A 45-year-old Japanese man was hospitalized for increasing left chest pain. Imaging revealed a 10-cm pleural tumor and a 1. Read More

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http://dx.doi.org/10.3892/mco.2018.1757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313927PMC
January 2019
1 Read

Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14063

Department of Surgery.

Rationale: The brain, liver, adrenal glands, and bone are the most common sites of metastatic disease in patients with lung cancer. Symptomatic gastrointestinal metastases are rare. In the present report, we describe a rare case of a patient with intestinal obstruction due to solitary colonic metastasis from primary lung adenocarcinoma, wherein the intestinal obstruction was the first symptom of lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014063DOI Listing
January 2019
1 Read

Seminal vesicle metastasis after liver transplantation for hepatocellular carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e13770

Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School.

Rationale: Cancer recurrence and metastasis after liver transplantation (LT) is common in some hepatocellular carcinoma (HCC) patients. The most common sites of extrahepatic metastases are lung, regional lymph node, adrenal gland, and bone. To our knowledge, HCC metastasis to the seminal vesicle after LT has not been reported in the literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000013770DOI Listing
January 2019
2 Reads

Survival outcomes following adrenalectomy for isolated metastases to the adrenal gland.

Eur J Surg Oncol 2019 Jan 4. Epub 2019 Jan 4.

Department of General Surgery, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, G51 4TF, United Kingdom.

Background: Adrenal metastases can arise from different primary sites. Surgical resection of the adrenal gland in patients with isolated metastases may offer improved survival in many of these patients. However, the benefit of surgery in this heterogenous group is often disputed. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.006DOI Listing
January 2019
1 Read

A Case of Stage IV Chromophobe Renal Cell Carcinoma Treated with the Oncolytic ECHO-7 Virus, Rigvir®.

Am J Case Rep 2019 Jan 12;20:48-52. Epub 2019 Jan 12.

International Virotherapy Center, Research and Development, Riga, Latvia.

BACKGROUND Renal cell carcinoma is the most commonly diagnosed primary malignant tumor of the kidney in adults, and includes the variant of chromophobe renal cell carcinoma. Despite new targeted therapies that improve progression-free survival (PFS) and overall survival (OS) for early-stage renal cell carcinoma, the 5-year survival for patients with stage IV renal cell carcinoma remains below 10%, and the 50% OS is less than one year. Metastatic renal cell carcinoma can be resistant to cytotoxic chemotherapy. Read More

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http://dx.doi.org/10.12659/AJCR.912115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340265PMC
January 2019
1 Read

Multidisciplinary approach for patients with functional and non-functional adrenal masses and review of the literature.

Health Sci Rep 2018 Mar 20;1(3):e22. Epub 2017 Dec 20.

Internal Medicine and Endocrinology, Department of Internal Medicine, Division of Endocrinology Cukurova University Medical Faculty Adana Turkey.

Background: Adrenal incidentalomas are adrenal masses that are discovered by imaging tests performed for other reasons.

Aims: In this retrospective study, we analysed 229 Turkish patients with adrenal masses and who presented with or without complaints.

Study Design: Descriptive retrospective study and review of the literature. Read More

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http://doi.wiley.com/10.1002/hsr2.22
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http://dx.doi.org/10.1002/hsr2.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266456PMC
March 2018
4 Reads

Laparoscopic adrenalectomy for metastatic disease: Retrospective cohort with long-term, comprehensive follow-up.

Surgery 2018 Dec 24. Epub 2018 Dec 24.

Division of Endocrine Surgery, Department of Surgery, University of California, San Francisco, CA.

Background: Several malignancies metastasize to the adrenal gland, especially non-small cell lung cancer, renal cell carcinoma, and melanoma. Adrenalectomy is associated with prolonged survival, but laparoscopic adrenalectomy for this indication is controversial. Our objective was to characterize and quantify outcomes after laparoscopic adrenalectomy for metastases to the adrenal gland. Read More

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http://dx.doi.org/10.1016/j.surg.2018.11.008DOI Listing
December 2018
11 Reads

Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and Viscum album Extract Treatment: A Case Report.

Perm J 2018 ;23

Institute for Applied Epistemology and Medical Methodology, University of Witten/Herdecke, Freiburg, Germany.

Introduction: Epithelial ovarian cancer (EOC) has a poor prognosis in advanced stages. High-dose chemotherapy (HDC) was pursued in the 1990s but was not found to improve survival of patients with EOC in larger studies. Many patients with cancer use Viscum album extracts (VAE). Read More

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http://dx.doi.org/10.7812/TPP/18-025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307551PMC
January 2018
1 Read

Role of Stereotactic Body Radiation Therapy for the Management of Oligometastatic Renal Cell Carcinoma.

J Urol 2019 01;201(1):70-75

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Purpose: Kidney cancer has been increasing 1.7% annually. Renal cell carcinoma is the most common kidney cancer and it can metastasize. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225347184379
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http://dx.doi.org/10.1016/j.juro.2018.08.049DOI Listing
January 2019
7 Reads

Computed tomography-guided cryoablation for adrenal metastases: local control and survival.

Medicine (Baltimore) 2018 Dec;97(51):e13885

Department of Oncology, Second Affiliated Hospital of Suzhou University, Suzhou.

To evaluate the feasibility, local control, and survival after computed tomography (CT)-guided cryoablation for adrenal metastases.This study included 31 consecutive patients with adrenal metastases who were treated by CT-guided cryoablation in our center from July 2011 to October 2017. The technical success rate, local progression rate, local progression-free survival (LPFS), systemic progression-free survival (SPFS), and overall survival were assessed. Read More

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http://dx.doi.org/10.1097/MD.0000000000013885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320079PMC
December 2018
5.723 Impact Factor

Pancreatic carcinoma underlying a complex presentation in late pregnancy: a case report.

J Med Case Rep 2018 Dec 15;12(1):369. Epub 2018 Dec 15.

Department of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's Hospital, Parkville, Australia.

Background: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Read More

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http://dx.doi.org/10.1186/s13256-018-1911-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295019PMC
December 2018

Perforation of small intestine secondary to metastatic lung adenocarcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13469

Department of Emergency Surgery, Union Hospital.

Rationale: About 50% of patients with a diagnosis of nonsmall cell lung carcinoma exhibit metastatic disease at the time of diagnosis. The preferential sites of extrapulmonary spread are the lymph nodes, liver, brain, adrenal glands, and bones; gastrointestinal tract perforation secondary to metastatic lung cancer is extremely rare.

Patient Concerns: A 60-year-old male nonsmoker patient presented with a 20-day history of facial, neck, and right upper limb edema. Read More

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http://dx.doi.org/10.1097/MD.0000000000013469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310494PMC
December 2018

[A Case of Renal Cell Carcinoma withIpsilateral Renal Pelvic Metastasis Mimicking Double Cancer].

Hinyokika Kiyo 2018 Nov;64(11):439-443

The Department of Urology, Rakuwakai Otowa Hospital.

A 71-year-old man with left flank pain was referred to our hospital. Computed tomography (CT) revealed a left renal tumor, left renal pelvic wall thickening, bilateral adrenal gland swelling, multiple pulmonary nodules, and a bone metastatic tumor. Further, positron emission tomography/CT revealed increased 18F fluorodeoxyglucose uptake in the left renal tumor, multiple pulmonary nodules, and bone metastatic tumor. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_11_439DOI Listing
November 2018

[Leiomyosarcoma of the adrenal gland - two cases report].

Pol Merkur Lekarski 2018 Nov;45(269):189-191

Maria Skłodowska-Curie Institute - Oncology Center of Warsaw, Poland: Department of Soft Tissue/Bone Sarcoma and Melanoma.

Primary adrenal leiomyosarcomas are very rare adrenal mesenchymal tumours, only few dozen has been reported in the English language literature so far. We present two cases of patients with primary adrenal leiomyoosarcomas. 80 year-old female admitted with left adrenal tumour with presumptive diagnosis of nonadenoma, laparoscopic adrenalectomy was performed and 85 year-old man who underwent surgical resection by laparotomy of adrenal tumour suspected for adrenal carcinoma. Read More

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November 2018
1 Read

New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study.

Lung Cancer 2018 Dec 5;126:139-148. Epub 2018 Nov 5.

National Korányi Institute of Pulmonology, Budapest, Hungary. Electronic address:

Introduction: The presence of organ metastases is a major factor for unfavorable prognosis in lung adenocarcinoma (LADC). However, the influence of primary tumor location on metastatic sites and sequence has not been extensively analyzed.

Methods: We performed a multicenter cohort study, evaluating clinicopathological data of 1126 Caucasian LADC patients, focusing on the distinct location of primary tumors and metastatic sites during disease progression. Read More

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http://dx.doi.org/10.1016/j.lungcan.2018.11.004DOI Listing
December 2018
1 Read

Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, Germany.

A major part of non-small cell lung cancer (NSCLC) patients treated with mono- or multimodal concept develop therapy resistance. Despite the abundance of biomarkers investigated in the past, there is still a need for valid NSCLC biomarkers. Glycodelin, an immunosuppressive endometrial protein, has been shown to be also expressed in NSCLC. Read More

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http://dx.doi.org/10.3390/cancers10120486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315759PMC
December 2018
4 Reads

Malignant Pheochromocytoma with Widespread Bony and Pulmonary Metastases.

Cureus 2018 Sep 24;10(9):e3348. Epub 2018 Sep 24.

Cardiothoracic Surgery, The Aga Khan University Hospital, Karachi, PAK.

Pheochromocytoma is a rare benign tumor of the adrenal gland. A select few cases may be malignant, and metastatic cases are exceedingly rare. It often presents with symptoms of catecholamine excess, such as sweating, palpitations, headaches, and characteristic paroxysmal hypertension. Read More

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https://www.cureus.com/articles/14062-malignant-pheochromocy
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http://dx.doi.org/10.7759/cureus.3348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255712PMC
September 2018
9 Reads

Synchronous Oligometastatic Lung Cancer deserves a dedicated management.

Ann Thorac Surg 2018 Nov 23. Epub 2018 Nov 23.

Thoracic Surgery Department, Paris Center University Hospital, AP-HP, Paris Descartes University, Paris, France. Electronic address:

Background: Oligometastatic stage IV Non-small Lung Cancer (NSCLC) patients have a 5-years overall survival of 30% versus 4-6% . We reviewed data and patterns of care of patients affected by oligometastatic NSCLC in our centre between 2001 and 2017.

Methods: We retrospectively reviewed clinical and pathological files of all patients with lung cancer and synchronous isolated adrenal and/or brain metastases, treated by locally ablative treatments (surgery and/or, radiotherapy) of both primary cancer and distant metastasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183168
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http://dx.doi.org/10.1016/j.athoracsur.2018.10.029DOI Listing
November 2018
21 Reads

[French ccAFU guidelines - Update 2018-2020: Adrenal cancer].

Prog Urol 2018 Nov 27;28(12S):S175-S193. Epub 2018 Oct 27.

Service d'urologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 09, France; Service d'urologie, hôpital européen Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France. Electronic address:

Objective: To update French oncology guidelines concerning adrenal cancer.

Methods: Comprehensive Medline search between 2016 and 2018 upon diagnosis, treatment and follow-up of adrenal cancer to update 2013 guidelines. Level of evidence was evaluated according to AGREE-II. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11667087183051
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http://dx.doi.org/10.1016/j.purol.2018.08.015DOI Listing
November 2018
15 Reads

Malignant phyllodes tumor with metastases to lung, adrenal and brain: A rare case report.

Ann Med Surg (Lond) 2018 Dec 2;36:113-117. Epub 2018 Nov 2.

Department of Dermatology, Tribhuvan University Teaching Hospital, Nepal.

Background: Phyllodes tumors are spectrum of tumors ranging from benign to malignant. Malignant spectrum pose a management challenge for clinicians due to high risks of recurrence and metastasis. Malignant phyllodes tumor with brain, lung and adrenal metastases at the same time is rare. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20490801183023
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http://dx.doi.org/10.1016/j.amsu.2018.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230968PMC
December 2018
19 Reads

Molecular Profiling of Pheochromocytoma and Abdominal Paraganglioma Stratified by the PASS Algorithm Reveals Chromogranin B as Associated With Histologic Prediction of Malignant Behavior.

Am J Surg Pathol 2019 Mar;43(3):409-421

Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, CCK.

Pheochromocytomas (PCCs) and abdominal paragangliomas (PGLs), collectively abbreviated PPGL, are believed to exhibit malignant potential-but only subsets of cases will display full-blown malignant properties. The Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) algorithm is a proposed histologic system to detect potential for aggressive behavior, but little is known regarding the coupling to underlying molecular genetics. In this study, a total of 92 PPGLs, previously characterized for susceptibility gene status and mRNA expressional profiles, were histologically assessed using the PASS criteria. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001190DOI Listing
March 2019
10 Reads

Long-term prognosis of low-risk neuroblastoma treated by surgery alone: an experience from a single institution of China.

World J Pediatr 2018 Nov 16. Epub 2018 Nov 16.

Department of Pediatric Surgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background: Low-risk neuroblastomas have favorable biologic characteristics. Children Oncology Group (COG) proposed that surgical resection of the primary tumor was sufficient. We evaluated the long-term prognosis of surgery alone for patients with low-risk neuroblastoma in China. Read More

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http://dx.doi.org/10.1007/s12519-018-0205-zDOI Listing
November 2018
2 Reads

Patterns of Lymph Node Recurrence in Adrenocortical Carcinoma: Possible Implications for Primary Surgical Treatment.

Ann Surg Oncol 2019 Feb 15;26(2):531-538. Epub 2018 Nov 15.

Department of General, Viszeral, and Thoracic Surgery, Kreisklinik Altötting, Altötting, Germany.

Background: In the surgical treatment of adrenocortical carcinoma (ACC), lymphadenectomy may improve oncologic outcome. However, patterns of metastatic lymphatic spread in ACC are unknown.

Methods: Clinical data of patients included in the European Network for the Study of Adrenal Tumors (ENSAT) registry were retrospectively reviewed. Read More

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http://link.springer.com/10.1245/s10434-018-6999-z
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http://dx.doi.org/10.1245/s10434-018-6999-zDOI Listing
February 2019
10 Reads

The Adrenal Gland as a Sanctuary Site of Metastases After Pembrolizumab Treatment: A Case Series.

J Natl Compr Canc Netw 2018 Nov;16(11):1279-1283

The Ohio State University Wexner Medical Center, and The Ohio State University James Comprehensive Cancer Center, Columbus, Ohio.

Therapeutic agents targeting the PD-1/PD-L1 axis have shown durable clinical responses in patients with various cancer types. Although objective responses are common, intrapatient heterogeneous responses have been described, and the mechanism for the different organ responses remains unknown. We present a series of patients in whom a lack of response was noted solely in the adrenal glands. Read More

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http://www.jnccn.org/lookup/doi/10.6004/jnccn.2018.7059
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http://dx.doi.org/10.6004/jnccn.2018.7059DOI Listing
November 2018
12 Reads

An Unusual Case of Papillary Thyroid Carcinoma Iodine-131 Avid Metastasis to the Adrenal Gland.

Acta Clin Croat 2018 Jun;57(2):372-376

Department of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Papillary thyroid carcinoma (PTC) is considered one of the most favorable tumors, indolent, with rare distant dissemination. Lungs and bones are the most common metastatic sites. Unusual sites of PTC distant metastases are extremely rare. Read More

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https://hrcak.srce.hr/index.php?show=clanak&id_clanak_je
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http://dx.doi.org/10.20471/acc.2018.57.02.20DOI Listing
June 2018
12 Reads

CT diagnosis for metastasis of clear cell renal cell carcinoma to the pancreas: Three case reports.

Medicine (Baltimore) 2018 Nov;97(46):e13200

Department of Radiology, Jinshan TCM-Integrated Hospital of Shanghai City, Shanghai.

Rationale: Clear cell renal cell carcinoma (CCRCC) metastasis to pancreas is clinically rare. Misdiagnosis for these cases is frequently due to the low incidence, lack of specific clinical symptoms, and laboratory results.

Patient Concerns: Three female patients aged 47 years, 69 years, and 76 years, respectively, were admitted to hospital for routine examination after resection of clear cell carcinoma of kidney for 69 months, 57 months, and 123 months, respectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000013200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257552PMC
November 2018
14 Reads

Detection of a unicentric type of Castleman-like mass at the site of adrenal grand: A case report and review of literature.

World J Clin Cases 2018 Nov;6(13):683-687

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.

We present a case of adrenal CD in a 26-year-old female. The patient was referred to our hospital because of left flank pain for 1 wk. A computed tomography scan revealed a 4 cm × 3 cm well-defined mass, considered as a paraganglioma. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i13.683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232562PMC
November 2018
1 Read

A phase 2 trial of abiraterone acetate without glucocorticoids for men with metastatic castration-resistant prostate cancer.

Cancer 2019 Feb 14;125(4):524-532. Epub 2018 Nov 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Background: Abiraterone acetate suppresses adrenal androgens and glucocorticoids through the inhibition of CYP17; however, given the risk of mineralocorticoid excess, it is administered with glucocorticoids. Herein, the authors performed a phase 2, single-arm study that was designed to assess the safety of abiraterone acetate without steroids in patients with castration-resistant prostate cancer.

Methods: Eligible patients had castration-resistant prostate cancer with controlled blood pressure and normal potassium. Read More

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http://doi.wiley.com/10.1002/cncr.31836
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http://dx.doi.org/10.1002/cncr.31836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353689PMC
February 2019
7 Reads

Nivolumab therapy for metastatic collecting duct carcinoma after nephrectomy: A case report.

Medicine (Baltimore) 2018 Nov;97(45):e13173

Department of Urology, Nippon Medical School Hospital, Sendagi, Bunkyo-ku, Tokyo, Japan.

Rationale: Collecting duct carcinoma (CDC) is a rare type of nonclear renal cell carcinoma, often presenting at an advanced stage of the disease, and standard treatment guidelines have not been established.

Patient Concerns: A 73-year-old man was admitted to our hospital with complaints of fever and lower right back pain.

Diagnoses: Computed tomography revealed a poorly defined tumor of the right kidney without metastasis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250451PMC
November 2018
10 Reads

Therapeutic Targets for Adrenocortical Carcinoma in the Genomics Era.

J Endocr Soc 2018 Nov 26;2(11):1259-1274. Epub 2018 Sep 26.

Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan.

Adrenocortical carcinoma (ACC) is a rare and often fatal cancer, affecting ~1 person per million per year worldwide. Approximately 75% of patients with ACC eventually develop metastases and progress on the few available standard-of-care medical therapies, highlighting an incredible need for an improved understanding of the molecular biology of this disease. Although it has long been known that ACC is characterized by certain histological and genetic features ( high mitotic activity, chromosomal instability, and overexpression of ), only in the last two decades of genomics has the molecular landscape of ACC been more thoroughly characterized. Read More

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https://academic.oup.com/jes/advance-article/doi/10.1210/js.
Publisher Site
http://dx.doi.org/10.1210/js.2018-00197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215083PMC
November 2018
8 Reads

First Reported Case of Endoscopic Ultrasound-Guided Core Biopsy Yielding Diagnosis of Primary Adrenal Leiomyosarcoma.

Case Rep Gastrointest Med 2018 3;2018:8196051. Epub 2018 Oct 3.

Division of Gastroenterology and Hepatology, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL, USA.

Primary adrenal leiomyosarcoma (PAL) is an extremely rare mesenchymal tumor with only a few isolated case reports in the medical literature. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or endoscopic ultrasound-guided core biopsy (EUS-CB) is a safe, effective modality for sampling lesions in the gastrointestinal tract and adjacent organs, including the adrenal glands. We describe the case of a 50-year-old male presenting with abdominal pain and unintentional weight loss over the course of one year. Read More

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https://www.hindawi.com/journals/crigm/2018/8196051/
Publisher Site
http://dx.doi.org/10.1155/2018/8196051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192140PMC
October 2018
12 Reads

Revisiting the role of the pathological grading in pediatric adrenal cortical tumors: results from a national cohort study with pathological review.

Mod Pathol 2018 Nov 6. Epub 2018 Nov 6.

Department of Pathology, Groupement Hospitalier Est, Hospices Civils de Lyon, UCBL Lyon 1 University, Lyon, France.

The prognosis of malignant pediatric adrenocortical tumors is closely related to disease stage, which is used to guide perioperative treatment recommendations. However, current scoring systems are inadequate to distinguish between benign and malignant adrenocortical tumors. Robust microscopic prognostic features that could help determine perioperative therapy are also lacking. Read More

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http://www.nature.com/articles/s41379-018-0174-8
Publisher Site
http://dx.doi.org/10.1038/s41379-018-0174-8DOI Listing
November 2018
9 Reads
6.190 Impact Factor

Hemodynamic instability during percutaneous ablation of extra-adrenal metastases of pheochromocytoma and paragangliomas: a case series.

BMC Anesthesiol 2018 Nov 6;18(1):158. Epub 2018 Nov 6.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA.

Background: Surgical manipulation of pheochromocytomas and paragangliomas (PPGLs) may induce large hemodynamic oscillations due to catecholamine release. Little is known regarding hemodynamic instability during percutaneous ablation of PPGLs. We examined intraprocedural hemodynamic variability and postoperative complications related to percutaneous ablation of extra-adrenal metastases of PPGL. Read More

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https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s12871-018-0626-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220566PMC
November 2018
10 Reads

Fractionated stereotactic radiation therapy for adrenal metastases: contributing to local tumor control with low toxicity.

Strahlenther Onkol 2018 Oct 29. Epub 2018 Oct 29.

Department of Radiation Oncology, Friedrich-Schiller-University Jena, Bachstraße 18, 07743, Jena, Germany.

Purpose: To report on the Erlangen (UK-Er) experience with linear accelerator stereotactic body radiation therapy (LINAC SBRT) for adrenal metastasis from various primary tumors.

Materials And Methods: 33 patients were treated. Primary sites included lung (n = 19), melanoma (n = 8), colorectal (n = 2), hepatocellular (n = 1), esophageal (n = 2), and breast cancer (n = 1). Read More

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http://link.springer.com/10.1007/s00066-018-1390-3
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http://dx.doi.org/10.1007/s00066-018-1390-3DOI Listing
October 2018
4 Reads

Stereotactic body radiation therapy for adrenal gland metastases: Outcomes and toxicity.

Adv Radiat Oncol 2018 Oct-Dec;3(4):621-629. Epub 2018 May 24.

Department of Radiation Oncology, Stanford Cancer Institute, Stanford, California.

Purpose: This study aimed to report on our institutional experience in the use of stereotactic body radiation therapy (SBRT) for the treatment of adrenal gland metastases. Specifically, we examined the outcomes and toxicity from this treatment modality on adjacent organs at risk.

Methods And Materials: Data were retrieved from patients with adrenal metastases who were treated with SBRT between 2008 and 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24521094183008
Publisher Site
http://dx.doi.org/10.1016/j.adro.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200881PMC
May 2018
12 Reads

Predictive factors for adrenal metastasis in extra-adrenal malignancy patients with solitary adrenal mass.

J Surg Oncol 2018 Dec 27;118(8):1271-1276. Epub 2018 Oct 27.

Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.

Background And Objectives: The adrenal gland is a frequent site for metastasis, and a solitary adrenal mass is often observed during staging workup or imaging follow-up in patients with extra-adrenal malignancy. To create an appropriate management plan, it is essential to distinguish between benign adrenal lesions and metastasis in patients with extra-adrenal cancer having solitary adrenal masses. Therefore, here we evaluated the predictive factors for adrenal metastasis in patients with extra-adrenal malignancy having solitary adrenal mass. Read More

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http://doi.wiley.com/10.1002/jso.25272
Publisher Site
http://dx.doi.org/10.1002/jso.25272DOI Listing
December 2018
12 Reads

TROG 15.03 phase II clinical trial of Focal Ablative STereotactic Radiosurgery for Cancers of the Kidney - FASTRACK II.

BMC Cancer 2018 Oct 23;18(1):1030. Epub 2018 Oct 23.

Radiation Oncology, Austin Health, Heidelberg, Australia.

Background: Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dialysis. The objective of the FASTRACK II clinical trial is to investigate the efficacy of SABR for primary RCC.

Methods: FASTRACK II is a single arm, multi-institutional phase II study. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-018-4916-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199711PMC
October 2018
10 Reads
3.362 Impact Factor

Short-term outcomes and clinical efficacy of stereotactic body radiation therapy (SBRT) in treatment of adrenal gland metastases from lung cancer.

Radiat Oncol 2018 Oct 22;13(1):205. Epub 2018 Oct 22.

Department of Radiation Oncology, Shanghai Changhai Hospital, the Second Military Medical University, Shanghai, 200433, China.

Background: To assess the efficacy and safety of stereotactic body radiation therapy (SBRT) in the management of adrenal gland metastases (AGMs) from lung cancer. Moreover, it is the first two-institutional experience and the largest-to-date study to report the safety and efficacy of SBRT for inoperable AGM from lung cancer.

Methods: In this retrospective study, 30 patients (27 males, 3 females) with 32 AGMs were treated by SBRT from October 2006 to June 2016. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-018-1152-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196411PMC
October 2018
9 Reads

Diagnostic and prognostic value of 18F-FDG PET/CT imaging in suspected recurrence of male breast cancer.

Nucl Med Commun 2019 Jan;40(1):63-72

Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: Male breast cancer (MBC) is a rare malignancy, with recurrence being one of the main adverse predictors for prognosis. The aim of the study was to evaluate the diagnostic and predictive value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in the setting of suspected recurrence of MBC.

Patients And Methods: Retrospective analysis of PET/CT findings was performed in 23 previously treated, histologically proven patients with MBC (mean age: 59. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282661PMC
January 2019
16 Reads

CT and MRI of adrenal gland pathologies.

Quant Imaging Med Surg 2018 Sep;8(8):853-875

Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.

Besides ultrasound and nuclear medicine techniques, computed tomography (CT) and magnetic resonance imaging (MRI) are commonly used to examine adrenal lesions in both symptomatic and asymptomatic patients. Some adrenal lesions have characteristic radiological features. If an adrenal nodule is discovered incidentally, determining whether the lesion is benign or malignant is of great importance. Read More

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http://qims.amegroups.com/article/view/21428/21140
Publisher Site
http://dx.doi.org/10.21037/qims.2018.09.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177362PMC
September 2018
16 Reads

Histogram Analysis of Adrenal Lesions With a Single Measurement for 10th Percentile: Feasibility and Incremental Value for Diagnosing Adenomas.

AJR Am J Roentgenol 2018 Dec 9;211(6):1227-1233. Epub 2018 Oct 9.

1 Department of Internal Medicine, Radiology Division, Ribeirao Preto School of Medicine, University of Sao Paulo, Hospital Clinicas, Avenue Bandeirantes 3900, Campus Monte Alegre, Ribeirao Preto 14049-900, Sao Paulo, Brazil.

Objective: Our purpose was to assess whether histogram analysis of adrenal lesions from a single measurement of mean attenuation and SD, using a threshold of 10% of negative voxels, can replace voxel counting while maintaining diagnostic accuracy.

Materials And Methods: In a 4-year period, 325 adrenal lesions were detected on CT examinations of 308 consecutive patients. After exclusions, 91 patients with 108 lesions, including 20 malignant lesions and 88 adenomas (defined by histologic results or follow-up), were enrolled. Read More

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https://www.ajronline.org/doi/10.2214/AJR.17.19159
Publisher Site
http://dx.doi.org/10.2214/AJR.17.19159DOI Listing
December 2018
4 Reads