298,180 results match your criteria Adrenal Insufficiency & Adrenal Crisis

Polymeric dexamethasone prodrugs attenuate lupus nephritis in MRL/lpr mice with reduced glucocorticoid toxicity.

Nanomedicine 2022 Jun 26:102579. Epub 2022 Jun 26.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6125, USA. Electronic address:

Due to their potent immunosuppressive and anti-inflammatory effects, glucocorticoids (GCs) are the most widely used medications in treating lupus nephritis (LN). Long-term use of GCs, however, is associated with numerous off-target adverse effects. To reduce GCs' adverse effects, we previously developed two polymeric dexamethasone prodrug nanomedicines: N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-based dexamethasone prodrug (P-Dex), and micelle-forming polyethylene glycol (PEG)-based dexamethasone prodrug (ZSJ-0228). Read More

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Cognitive dysfunction in patients with primary adrenal insufficiency: A systematic review.

Appl Neuropsychol Adult 2022 Jun 29:1-12. Epub 2022 Jun 29.

Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigación San Carlos, IdISSC, Universidad Complutense, Madrid, Spain.

Addison's disease (AD) entails a chronic insufficient production of gluco- and mineralocorticoids. Fatigue and decreased quality of life are frequently reported symptoms, but little is known about its effects on cognition. This study aims to explore the existence of cognitive impairment in patients with AD and the influence of treatment regimens. Read More

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Primary Aldosteronism: State-of-the-Art Review.

Am J Hypertens 2022 Jun 29. Epub 2022 Jun 29.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School.

We are witnessing a revolution in our understanding of primary aldosteronism. In the past two decades, we have learned that primary aldosteronism is a highly prevalent syndrome that is largely attributable to pathogenic somatic mutations, that contributes to cardiovascular, metabolic, and kidney disease, and that when recognized, can be adequately treated with widely available mineralocorticoid receptor antagonists and/or surgical adrenalectomy. Unfortunately, primary aldosteronism is rarely diagnosed, or adequately treated, mainly because of a lack of awareness and education. Read More

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Endocrine manifestations of paediatric intracranial germ cell tumours: from diagnosis to long-term follow-up.

Endocrine 2022 Jun 29. Epub 2022 Jun 29.

Department of Paediatric Endocrinology, Royal Marsden NHS Foundation Trust, London, UK.

Purpose: We examined endocrine manifestations in a cohort of paediatric patients with IC-GCTs at diagnosis and during follow-up, integrating clinical, radiological, histopathological and laboratory data.

Methods: Diabetes insipidus (DI), growth hormone deficiency (GHD), hypothyroidism, adrenal insufficiency, precocious puberty (PP)/hypogonadism were diagnosed clinically and biochemically. The prevalence of endocrine manifestations was compared to survival rates. Read More

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Editorial Comment: Does Washout CT Still Have a Role for Characterization of Adrenal Incidentalomas?

AJR Am J Roentgenol 2022 Jun 29. Epub 2022 Jun 29.

Department of Radiology, Beth Israel Deaconess Medical Center - Harvard Medical School, Boston, MA 02215.

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Radiomics in Abdominopelvic Solid-Organ Oncologic Imaging: Current Status.

AJR Am J Roentgenol 2022 Jun 29. Epub 2022 Jun 29.

Department of Abdominal Imaging, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Radiomics is the process of extraction of high-throughput quantitative imaging features from medical images. These features represent non-invasive quantitative biomarkers that go beyond the traditional imaging features visible to the human eye. This article first reviews the steps of the radiomics pipeline, including image acquisition, ROI selection and image segmentation, image preprocessing, feature extraction, feature selection, and model development and application. Read More

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Ulipristal-temozolomide-hydroxyurea combination for glioblastoma: in-vitro studies.

J Neurosurg Sci 2022 Jun 28. Epub 2022 Jun 28.

Department of Medical Pharmacology, Ataturk University, Erzurum, Turkey.

Background: Glioblastoma multiforme (GBM) is a brain malignancy with worst survival. Low dose progesterone stimulates GBM growth, while progesterone receptor (PR)-antagonist mifepristone was shown to reduce growth and to enhance temozolomide sensitivity in GBM cells. Mifepristone is not available in all countries due to ethical reasons and may cause adrenal insufficiency and pelvic infections. Read More

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Hepatoid prostatic carcinoma with adrenal metastasis and novel genetic alterations.

Diagn Cytopathol 2022 Jun 28. Epub 2022 Jun 28.

Department of Pathology, The George Washington University Hospital, Washington, District of Columbia, USA.

Hepatoid carcinoma (HC) encompasses epithelial extrahepatic tumors exhibiting features of hepatocellular carcinoma (HCC) both by morphology and immunohistochemistry. Distinguishing metastatic HCC from HC may be challenging, particularly when limited material, such as a cytologic specimen, is available. HC from prostatic origin is unusual and has only rarely been characterized by cytology. Read More

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Primary adrenal insufficiency.

Clin Case Rep 2022 Jun 19;10(6):e6002. Epub 2022 Jun 19.

Johns Hopkins Community Physicians Johns Hopkins Medicine Baltimore Maryland USA.

Primary adrenal insufficiency is a potentially life-threatening condition. We report a case of a 49-year-old female patient who presented to the hospital for evaluation of dizziness, nausea, and vomiting. Darkening of the palmar creases and tongue was noted. Read More

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Stress-induced HPA activation in virtual navigation and spatial attention performance.

BMC Neurosci 2022 Jun 28;23(1):40. Epub 2022 Jun 28.

Department of Psychology, Saint Michael's College, One Winooski Park, Colchester, VT, 05439, USA.

Background: Previous research has shown that spatial performance (e.g. navigation, visuospatial memory, attention) can be influenced by acute stress; however, studies have produced mixed findings sometimes showing an improvement after stress, other times showing impairment or no overall effect. Read More

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Refractory postoperative Staphylococcus hominis bacteremia in a patient with an ACTH-producing pancreatic neuroendocrine neoplasm: a case report.

Surg Case Rep 2022 Jun 29;8(1):126. Epub 2022 Jun 29.

Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.

Background: Staphylococcus hominis (S. hominis) is an opportunistic pathogen that is often highly resistant to antibiotics and is difficult to treat. In patients diagnosed with an adrenocorticotropic hormone (ACTH)-producing tumor that compromises the immune system due to hypercortisolemia, cancer treatment and infection control should be considered simultaneously. Read More

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MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma.

Nat Commun 2022 Jun 28;13(1):3728. Epub 2022 Jun 28.

Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX, 77030, USA.

Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification is found in half of high-risk NB patients; however, no available therapies directly target MYCN. Using multi-dimensional metabolic profiling in MYCN expression systems and primary patient tumors, we comprehensively characterized the metabolic landscape driven by MYCN in NB. Read More

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[Research progress of neuroendocrine mechanism of acupuncture for dyspnea].

Zhen Ci Yan Jiu 2022 Jun;47(6):559-64

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041.

The paper reviewed the relevant studies on dyspnea treated with acupuncture over the past 20 years, as well as the underlying neuroendocrine mechanism from the perspective of central and peripheral vagus nerves, neurotransmitter, respiratory muscle function and anti-depression-anxiety function. It revealed that the central response area was regulated by acupuncture in treatment of dyspnea, which is similar to the area affected in acupuncture analgesia. Additionally, acupuncture generates its therapeutic effects on dyspnea through promoting the release of endogenous opioid peptides and the regulation of autonomic nerve, amygdale and hypothalamic-pituitary-adrenal axis. Read More

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Congenital adrenal hyperplasia in a child with 47, XYY: Case report.

J Pediatr Nurs 2022 Jul-Aug;65:127-128

Emory University, School of Medicine, Department of Human Genetics, USA.

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J Pharmacol Exp Ther 2022 Jun 28. Epub 2022 Jun 28.

Poxel SA, France.

: X-linked adrenoleukodystrophy (ALD) is a severe orphan disease caused by mutations in the peroxisomal transporter gene, leading to toxic accumulation of Very Long-Chain Fatty Acids (VLCFA - in particular C26:0) resulting in inflammation, mitochondrial dysfunction and demyelination. AMP-activated protein kinase (AMPK) is downregulated in ALD, and its activation is implicated as a therapeutic target. PXL770 is the first direct allosteric AMPK activator with established clinical efficacy and tolerability. Read More

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[Ketamine as a treatment of bronchospasm due to an anaphylaxis. A case report].

Rev Med Inst Mex Seguro Soc 2022 May 2;60(3):356-360. Epub 2022 May 2.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Cuidados Intensivos. Ciudad de México, México.

Background: Ketamine is used in intravenous anesthesia for the maintenance in the general anesthesia. It has characteristics to prevent the difficult of breathing due to bronchospasm, as well as the delivery of histamine associated with asthmatic attack. These effects come from the direct action in the bronchial muscle, as well as from the potentiation of its catecholamines, which is why its use is very controversial, given that there are not enough trials to back it up. Read More

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Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways.

Environ Toxicol 2022 Jun 28. Epub 2022 Jun 28.

Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Phthalates may interfere with the biosynthesis of steroid hormones in the adrenal cortex. Bis (2-butoxyethyl) phthalate (BBOP) is a phthalate containing oxygen atoms in the alcohol moiety. In this study, 35-day-old male Sprague-Dawley rats were daily gavaged with BBOP (0, 10, 100, 250, and 500 mg/kg body weight) for 21 days. Read More

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Digital histological morphometry of the human pineal gland in a postmortem study, with endocrine and neurological clinical implications.

Anat Histol Embryol 2022 Jun 28. Epub 2022 Jun 28.

Emergency Clinical County Hospital Cluj-Napoca, Cluj-Napoca, Romania.

The pineal gland is a small-sized, photo neuroendocrine organ in the midline of the brain that synthesises and secretes melatonin and serotonin. Chords and islands of pinealocytes constitute the secretory parenchyma, while glial tissue and calcifications represent degenerative changes. This study examined human postmortem pineal glands to microscopically assess morphological changes possibly associated with clinical data, by using digital techniques. Read More

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The operation of carotid endarterectomy: is it an effective method of treatment of arterial hypertension?

Panminerva Med 2022 Jun 28. Epub 2022 Jun 28.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University, Rome, Italy.

Aim: To establish the relationship between AH and hemodynamically significant atherosclerotic stenosis of carotid bifurcation and study the effect of carotid endarterectomy (CEA) on the course of AH.

Materials And Methods: In our investigation we included 320 patients: 243 (75,9%) men and 77 (24,1%), the mean age - 59,6 ± 8,2. All patients underwent CEA operation. Read More

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Development and evaluation of a patient education programme for children, adolescents, and young adults with differences of sex development (DSD) and their parents: study protocol of Empower-DSD.

BMC Endocr Disord 2022 Jun 27;22(1):166. Epub 2022 Jun 27.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, and Berlin Institut of Health, SPZ Interdisziplinär, Kinderendokrinologie und -diabetologie, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: Differences in sexual development (DSD) are rare diseases, which affect the chromosomal, anatomical or gonadal sex differentiation. Although patient education is recommended as essential in a holistic care approach, standardised programmes are still lacking. The present protocol describes the aims, study design and methods of the Empower-DSD project, which developed an age-adapted multidisciplinary education programme to improve the diagnosis-specific knowledge, skills and empowerment of patients and their parents. Read More

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Cyclophosphamide therapy as an adjunct in refractory post-tubercular arachnoiditis.

Indian J Tuberc 2022 Jul 29;69(3):325-333. Epub 2021 May 29.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: There is no satisfactory treatment for post tubercular arachnoiditis (TB arachnoiditis). We did this study to investigate the efficacy and safety of cyclophosphamide as adjuvant therapy for post TB arachnoiditis refractory to corticosteroids and anti-tubercular therapy (ATT).

Methods: This was a retrospective case series of patients of refractory post TB arachnoiditis leading to paraparesis and vision loss who received cyclophosphamide as an adjuvant therapy along with standard ATT and corticosteroids. Read More

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[Adrenal myelolipoma, review of the literature in Mexico apropos of two cases].

Rev Med Inst Mex Seguro Soc 2022 Mar 1;60(2):229-235. Epub 2022 Mar 1.

Secretaría de Salud. Hospital General de México "Dr. Eduardo Liceaga", Departamento de Anatomía Patológica. Ciudad de México, México.

Background: Adrenal myelolipomas (ML) are rare benign neoplasms compound of adipose and myeloid tissue. Clinically they are usually asymptomatic, being diagnosed generally by incident. In Mexico, there are only 32 published cases of ML, these occur between 37 and 65 years, with the male-female ratio being 1:1. Read More

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Neurohormonal Connections with Mitochondria in Cardiomyopathy and Other Diseases.

Gerald W Dorn Ii

Am J Physiol Cell Physiol 2022 Jun 27. Epub 2022 Jun 27.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States.

Neurohormonal signaling and mitochondrial dynamism are seemingly distinct processes that are almost ubiquitous among multicellular organisms. Both of these processes are regulated by GTPases, and disturbances in either can provoke disease. Here, inconspicuous pathophysiological connectivity between neurohormonal signaling and mitochondrial dynamism is reviewed in the context of cardiac and neurological syndromes. Read More

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Adrenal Insufficiency among Children treated with Hormonal Therapy for Infantile Spasms.

Epilepsia 2022 Jun 27. Epub 2022 Jun 27.

Mother-Child Center - Quebec City University Hospital, QC, Canada.

Objective: Hormonal therapy is a standard treatment for children with infantile spasms. However, the high doses given, and long treatment duration expose patients to the risk of adrenal insufficiency (AI). This study aims to quantify the cumulative incidence of AI among children with infantile spasms treated with high-dose corticosteroids and/or adrenocorticotropic hormone. Read More

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Risk factors for discontinuing oral immunotherapy in children with persistent cow milk allergy.

Immun Inflamm Dis 2022 Jul;10(7):e668

Institute for Maternal and Child Health IRCCS "Burlo Garofolo", Trieste, Italy.

Background: There are no universally accepted criteria for discontinuing milk oral immunotherapy (MOIT) in patients with persistent cow milk allergy (CMA) and little data are available on predictive risk factors for dropping out from oral immunotherapy (OIT), due to allergic reactions or other reasons.

Methods: We retrospectively reviewed clinical records of patients with persistent severe CMA undergoing MOIT in a tertiary care center hospital to investigate risk factors associated with discontinuation of OIT. Persistent and severe allergy was defined as the history of systemic reactions and any milk protein-specific IgE level >85 kU/ml. Read More

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Central adrenal insufficiency: who, when, and how? From the evidence to the controversies - an exploratory review.

Arch Endocrinol Metab 2022 Jun 23. Epub 2022 Jun 23.

Unidade de Endocrinologia do Desenvolvimento, Disciplina de Endocrinologia, Departamento de Clínica Médica, Hospital das Clínicas, Faculdade de Medicina, Universidade São Paulo, São Paulo, SP, Brasil,

Central adrenal insufficiency (CAI) is a life-threatening disorder. This occurs when ACTH production is insufficient, leading to low cortisol levels. Since corticosteroids are crucial to many metabolic responses under organic stress and inflammatory conditions, CAI recognition and prompt treatment are vital. Read More

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J Zoo Wildl Med 2022 Jun;53(2):433-441

Biomedical Diagnostic Services, Knoxville, TN 37996, USA.

This retrospective study reviews the diseases associated with morbidity and mortality in 221 budgerigars () from a captive population from 2013 to 2019. The study aimed to evaluate the health status of a flock of budgerigars typical of today's zoologic collections. Based on previous literature, it was hypothesized that age-related conditions such as neoplasia would be common, whereas metabolic and nutritional disorders would be less common. Read More

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Love and longevity: A Social Dependency Hypothesis.

Compr Psychoneuroendocrinol 2021 Nov 30;8:100088. Epub 2021 Sep 30.

University of Virginia and Indiana University, United States.

Mammals, including humans, are reliant for survival and reproduction on adaptations associated with sociality and physiological investment, which can be linked to interactions with their parents or other bonded adult conspecifics. A wide range of evidence in human and non-human mammal species links social behaviors and relationships - including those characterized by what humans call "love" - to positive health and longevity. In light of this evidence, we propose a Social Dependency Hypothesis of Longevity, suggesting that natural selection has favored longer and healthier adult lives in species or in individuals exhibiting enhanced caregiver responsibilities contributing to the success of the next generation. Read More

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November 2021

The influence of psychosocial and sexual wellbeing on quality of life in women with differences of sexual development.

Compr Psychoneuroendocrinol 2021 Nov 24;8:100087. Epub 2021 Sep 24.

Department of Medical Psychology, Amsterdam University Medical Centers, location VUmc, Amsterdam, the Netherlands.

Background: Previous research indicating that women with differences of sexual development (DSD), namely women with Turner syndrome (TS), women with congenital adrenal hyperplasia (CAH), and women with XY-DSD, have an impaired psychosocial and sexual well-being and quality of life (QOL), was often limited by small samples and inadequate control groups (CGs). Only few studies analysed which psychosocial and sexual factors influence QOL in women with DSD and no study so far has examined whether the DSD-condition itself and the diagnostic group to which they belong moderate this influence.

Methods: We compared 301 women with TS, 221 women with CAH and 142 women with XY-DSD with 603 non-DSD women regarding depression, anxiety, self-esteem, attention deficit hyperactivity disorder, autism, social participation, body acceptance, relationship status, sexual satisfaction and QOL. Read More

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November 2021