17,203 results match your criteria Adrenal Insufficiency & Adrenal Crisis


Endocrine and metabolic aspects of the COVID-19 pandemic.

Rev Endocr Metab Disord 2020 Jul 9. Epub 2020 Jul 9.

Endocrinology and Nutrition Service, Department of Medicine, Germans Trias i Pujol Research Institute and Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.

COVID-19 infection has tremendously impacted our daily clinical practice as well as our social living organization. Virtually all organs and biological systems suffer from this new coronavirus infection, either because the virus targets directly specific tissues or because of indirect effects. Endocrine diseases are not an exception and some of endocrine organs are at risk of direct or indirect lesion by COVID-19. Read More

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http://dx.doi.org/10.1007/s11154-020-09569-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343578PMC

Safety and Efficacy of Nivolumab in Patients With Advanced Clear Cell Renal Cell Carcinoma: Results From the Phase IIIb/IV CheckMate 374 Study.

Clin Genitourin Cancer 2020 Jun 14. Epub 2020 Jun 14.

US Oncology, Comprehensive Cancer Centers of Nevada, Las Vegas, NV.

Background: The open-label, phase IIIb/IV CheckMate 374 study (NCT02596035) was conducted to validate the safety and efficacy of flat-dose nivolumab monotherapy 240 mg every 2 weeks (Q2W) in previously treated advanced/metastatic renal cell carcinoma (RCC). Three cohorts included patients with predominantly clear cell histology, non-clear cell histologies, or brain metastases. We report safety and efficacy from the CheckMate 374 advanced clear cell RCC (ccRCC) cohort. Read More

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http://dx.doi.org/10.1016/j.clgc.2020.06.002DOI Listing

New Horizons: Novel Adrenal Regenerative Therapies.

J Clin Endocrinol Metab 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Adrenal insufficiency requires lifelong corticoid replacement therapies. However, current therapies are not able to replace the physiological circadian pattern of the adrenal cortex and are associated with many metabolic, vascular, neuroendocrine and mental perturbations. Therefore, regenerative and more curative strategies would be desirable. Read More

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http://dx.doi.org/10.1210/clinem/dgaa438DOI Listing

Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor.

Front Cell Dev Biol 2020 17;8:499. Epub 2020 Jun 17.

Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Amsterdam UMC, Amsterdam Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, Netherlands.

X-linked adrenoleukodystrophy (ALD) is a devastating metabolic disorder affecting the adrenal glands, brain and spinal cord. Males with ALD are at high risk for developing adrenal insufficiency or progressive cerebral white matter lesions (cerebral ALD) at an early age. If untreated, cerebral ALD is often fatal. Read More

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http://dx.doi.org/10.3389/fcell.2020.00499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311642PMC

Paediatric population pharmacokinetic modelling to assess hydrocortisone replacement dosing regimens in young children.

Eur J Endocrinol 2020 Jul 1. Epub 2020 Jul 1.

C Kloft, Department of Clinical Pharmacy and Biochemistry, Freie Universität Berlin Institute of Pharmacy, Berlin, 12169, Germany.

Context: Accurate hydrocortisone dosing in children with adrenal insufficiency is important to avoid the risks of over and under treatment including iatrogenic Cushing`s syndrome and adrenal crisis.

Objective: To establish a population pharmacokinetic model of hydrocortisone in children and use this to refine hydrocortisone replacement regimens.

Design And Methods: Pharmacokinetic study of hydrocortisone granules, available in 0. Read More

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http://dx.doi.org/10.1530/EJE-20-0231DOI Listing

Systematic Review and Meta-Analysis of the Metabolic Effects of Modified-Release Hydrocortisone versus Standard Glucocorticoid Replacement Therapy in Adults with Adrenal Insufficiency.

Clin Endocrinol (Oxf) 2020 Jul 3. Epub 2020 Jul 3.

Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.

Context: Published studies exploring the metabolic effects of Modified-Release Hydrocortisone (MR-HC) replacement in patients with adrenal insufficiency (AI).

Objective: To compare metabolic effects of MR-HC with Standard Glucocorticoid (SG) replacement in adults with AI. Randomised control trials (RCTs) were meta-analysed; non-RCT studies described narratively with critical appraisal. Read More

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http://dx.doi.org/10.1111/cen.14275DOI Listing

Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: a reply.

Authors:
A Vercueil

Anaesthesia 2020 Jul 3. Epub 2020 Jul 3.

Intensive Care Unit, Kings College London, UK.

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http://dx.doi.org/10.1111/anae.15191DOI Listing

Evolution of histomorphologic, cytogenetic, and genetic abnormalities in an untreated patient with MIRAGE syndrome.

Cancer Genet 2020 Jun 14;245:42-48. Epub 2020 Jun 14.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Abramson Research Center, Room 716D, 3615 Civic Center Blvd., Philadelphia, PA 19104, United States; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

Gain of function variants in SAMD9 cause MIRAGE syndrome, a rare Mendelian disorder that results in myeloid dysplastic syndrome (MDS), poor immune response, restricted growth, adrenal insufficiency, ambiguous genitalia, feeding difficulties and most often significantly reduced lifespan. In this study, we describe histomorphologic and genetic changes occurring in serial bone marrow measurements in a patient with MIRAGE syndrome and untreated MDS of 9 years. Histomorphological analysis during childhood showed progressive hypocellularity with erythroid and megakaryocytic dysplasia and cytogenetic testing demonstrated monosomy 7. Read More

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http://dx.doi.org/10.1016/j.cancergen.2020.06.002DOI Listing

Clinical, endocrinological, and molecular features of four Korean cases of cytochrome P450 oxidoreductase deficiency.

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):97-103. Epub 2020 Jun 30.

Depar tment of Pediatrics, Asan Medical Center, Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Cytochrome P450 oxidoreductase (POR) deficiency is a rare autosomal recessive disorder caused by mutations in the POR gene encoding an electron donor for all microsomal P450 enzymes. It is characterized by adrenal insufficiency, ambiguous genitalia, maternal virilization during pregnancy, and skeletal dysplasia. In this study, we investigated the clinical, hormonal, and molecular characteristics of patients with POR deficiency in Korea. Read More

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http://dx.doi.org/10.6065/apem.1938152.076DOI Listing

Bilateral adrenal haemorrhage secondary to rivaroxaban in a patient with antiphospholipid syndrome.

BMJ Case Rep 2020 Jul 1;13(7). Epub 2020 Jul 1.

Internal Medicine and Pediatrics, Jackson Memorial Hospital, Miami, Florida, USA.

A 46-year-old man with antiphospholipid syndrome (APS) and previous pulmonary embolism on anticoagulation with rivaroxaban was brought in to the hospital after a syncopal episode. He was found to be hypotensive and tachycardic and later admitted to the intensive care unit. Clinical presentation and laboratory findings were consistent with adrenal insufficiency. Read More

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http://dx.doi.org/10.1136/bcr-2020-234947DOI Listing

Non-Classic Disorder of Adrenal Steroidogenesis and Clinical Dilemmas in 21-Hydroxylase Deficiency Combined with Backdoor Androgen Pathway. Mini-Review and Case Report.

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-653 Poznan, Poland.

Congenital adrenal hyperplasia (CAH) is the most common cause of primary adrenal insufficiency in children and adolescents. It comprises several clinical entities associated with mutations in genes, encoding enzymes involved in cortisol biosynthesis. The mutations lead to considerable (non-classic form) to almost complete (classic form) inhibition of enzymatic activity, reflected by different phenotypes and relevant biochemical alterations. Read More

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http://dx.doi.org/10.3390/ijms21134622DOI Listing

Comparison of a combination test (1 μg ACTH test plus glucagon test) versus 1 μg ACTH test and glucagon test in the evaluation of the hypothalamic-pituitary-adrenal axis in patients with pituitary disorders.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Department of Endocrinology, Yeditepe University Medical School, Istanbul, Turkey.

Objective: To investigate whether a combination of the low-dose (1 µg) adrenocorticotropin (ACTH) stimulation test and glucagon stimulation test (GST) could overcome the problem of equivocal results with the GST or ACTH test alone in patients with pituitary disorders.

Subjects And Methods: The study included 41 adult patients with pituitary disorders and 20 healthy subjects who underwent evaluation of cortisol response to ACTH, GST, and a combination of both tests. Blood samples for cortisol measurement were obtained at baseline and 30, 60, 90, and 120 minutes after intravenous administration of ACTH 1 μg and 90, 120, 150, 180, 210, and 240 minutes after subcutaneous injection of glucagon 1 mg. Read More

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http://dx.doi.org/10.20945/2359-3997000000266DOI Listing

Incidence of Adrenal Insufficiency and Cushing's Syndrome After Long-Term Epidural Steroid Injections Over Six Months or Longer: A Preliminary Study.

J Pain Res 2020 24;13:1505-1514. Epub 2020 Jun 24.

Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: Endocrinological complications of an epidural steroid injection (ESI) are rare but dangerous. Nevertheless, despite the associated risks, repeated long-term ESIs are indispensable in some clinical situations. However, only a few reports to date have assessed the safety of this procedure. Read More

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http://dx.doi.org/10.2147/JPR.S252278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321692PMC

Endocrine and Metabolic Manifestations of Snakebite Envenoming.

Am J Trop Med Hyg 2020 Jun 29. Epub 2020 Jun 29.

Department of Endocrinology, Manipal Hospital, New Delhi, India.

Snake envenoming is a neglected, public health problem in tropical and subtropical regions. Local tissue necrosis, neurotoxic, and hemo-vasculotoxic effects are well-recognized features, whereas the endocrine and metabolic derangements are not as well known. In addition to contributing to morbidity, some of these manifestations can be potentially life-threatening if not recognized early. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0161DOI Listing

Survivorship in immune therapy: Assessing toxicities, body composition and health-related quality of life among long-term survivors treated with antibodies to programmed death-1 receptor and its ligand.

Eur J Cancer 2020 Jun 26;135:211-220. Epub 2020 Jun 26.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Aim: Antibodies to programmed death-1 receptor and its ligand (anti-PD-1/PD-L1) produce durable responses in many cancers. However, the long-term effects of anti-PD-1/PD-L1 blockade are not well defined. We identified the toxicities, health outcomes and health-related quality of life (HRQoL) amongst long-term survivors treated with anti-PD-1/PD-L1. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.05.005DOI Listing

Letter to the Editor from Richard Dorin: "Dynamic pituitary-adrenal interactions in the critically ill after cardiac surgery".

J Clin Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Professor of Statistics and Mathematics Emeritus, University of New Mexico.

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http://dx.doi.org/10.1210/clinem/dgaa418DOI Listing

Primary Adrenal Insufficiency during Immune Checkpoint Inhibitor Treatment: Case Reports and Review of the Literature.

Case Rep Oncol 2020 May-Aug;13(2):621-626. Epub 2020 Jun 9.

Medical Oncology Service Bradford Hill, Santiago de Chile, Chile.

As the indications and clinical use of immune checkpoint inhibitors increase, it is expected that we will face some of their less frequently reported complications. Primary adrenal insufficiency is one of them, and given its unspecific symptoms and potentially serious consequences, it is important to have a high degree of clinical suspicion. We present 3 cases and a review of the literature concerning its main clinical characteristics, diagnostics, and management. Read More

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http://dx.doi.org/10.1159/000507652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315192PMC

Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test.

J Clin Endocrinol Metab 2020 Aug;105(8)

Department of Endocrinology, Sheffield Children's NHS Foundation Trust, Sheffield, United Kingdom.

Context: The Short Synacthen Test (SST) is the gold standard for diagnosing adrenal insufficiency. It requires invasive administration of Synacthen, venous sampling, and is resource-intensive.

Objective: To develop a nasally administered SST, with salivary glucocorticoids measurement, to assess the adrenal response. Read More

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http://dx.doi.org/10.1210/clinem/dgaa323DOI Listing

4th A in a triple A syndrome - A rare case report.

J Basic Clin Physiol Pharmacol 2020 Jun 24. Epub 2020 Jun 24.

Department of Physiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, India.

Objectives AAA (Allgrove) syndrome is a rare genetic disorder characterized by cardinal features of adrenal insufficiency, achalasia, and alacrimia. Case presentation A 21 year girl of known case of Triple A syndrome was referred for the evaluation of autonomic function. She was born full term with developmental delay and abnormal gait. Read More

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http://dx.doi.org/10.1515/jbcpp-2019-0293DOI Listing

Avascular necrosis of the femoral head due to low-dose corticosteroid used in a patient with panhypopituitarism: A case report and literature review.

Jt Dis Relat Surg 2020 18;31(2):390-394. Epub 2020 Jun 18.

Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Endokrinoloji ve Metabolizma Kliniği, 06110 Dışkapı, Ankara, Türkiye.

Osteonecrosis, commonly known as avascular necrosis (AVN) of bone, is one of the universally recognized side effects of high-dose steroids and commonly involves femur head leading to significant morbidity. However, the development of AVN in the femoral head due to low-dose oral corticosteroid therapy in a short time is a rare occurrence. Management by stopping corticosteroid treatment can be challenging in many cases due to the adrenal crisis. Read More

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http://dx.doi.org/10.5606/ehc.2020.72773DOI Listing

Tyrosine Kinase Inhibitors' Newly Reported Endocrine Side Effect: Pazopanib-Induced Primary Adrenal Insufficiency in a Patient With Metastatic Renal Cell Cancer.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620936808

University of Arizona, Phoenix, AZ, USA.

Tyrosine kinase inhibitors (TKIs) have been used in the treatment of multiple types of cancer. Pazopanib is one of the TKIs and is considered a first-line treatment for adult patients with metastatic renal cell carcinoma. Many endocrine-related adverse effects have been noted with the use of TKIs including hypothyroidism, vitamin D deficiency, altered bone density, secondary hyperparathyroidism, abnormal glucose metabolism, gynecomastia, and hypogonadism. Read More

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http://dx.doi.org/10.1177/2324709620936808DOI Listing

Standardised patient education in adrenal insufficiency: a prospective multi-centre evaluation.

Eur J Endocrinol 2020 Aug;183(2):119-127

Endocrinology and Diabetes Unit, Department of Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany.

Objective: Patients with adrenal insufficiency (AI) suffer from impaired quality of life and are at risk of adrenal crisis (AC) despite established replacement therapy. Patient education is regarded an important measure for prevention of AC and improvement of AI management. A standardized education programme was elaborated for patients with chronic AI in Germany. Read More

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http://dx.doi.org/10.1530/EJE-20-0181DOI Listing

The role of glucocorticoid supplementation in children with secondary adrenal insufficiency undergoing anaesthesia for imaging examinations.

Anaesthesia 2020 Jun 23. Epub 2020 Jun 23.

St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1111/anae.15031DOI Listing

CLINICAL PRESENTATION AND OUTCOMES OF OPIOID INDUCED ADRENAL INSUFFICIENCY.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Division of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, MN, USA.

Opioid-induced adrenal insufficiency (OIAI) may develop in patients treated with chronic opioids due suppression of the hypothalamic-pituitary-adrenal axis. Our objective was to describe clinical manifestations, biochemical presentation and clinical course of OIAI. A retrospective study of adults diagnosed with OIAI between 2006 and 2018 at an academic center. Read More

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http://dx.doi.org/10.4158/EP-2020-0297DOI Listing

Presentation, Disease Progression, and Outcomes of Adrenal Gland Metastases.

Clin Endocrinol (Oxf) 2020 Jun 22. Epub 2020 Jun 22.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA.

Objective: Data on the presentation and outcomes of patients with adrenal gland metastases are limited. Our objectives were to characterize the prevalence of adrenal metastases subtypes and investigate how varying clinical presentations affect disease progression, development of primary adrenal insufficiency (PAI), and mortality.

Design: Single institution tertiary center, retrospective cohort study from 1997 to 2020. Read More

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http://dx.doi.org/10.1111/cen.14268DOI Listing

Clinical Spectrum of Primary Adrenal Lymphoma: Results of a Multicenter Cohort Study.

Eur J Endocrinol 2020 Jun 1. Epub 2020 Jun 1.

N Gattermann, Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University Düsseldorf, Dusseldorf, Germany.

Purpose: We sought to refine the clinical picture of primary adrenal lymphoma (PAL), a rare lymphoid malignancy with predominant adrenal manifestation and risk of adrenal insufficiency.

Methods: 97 patients from 14 centers in Europe, Canada and the United States were included in this retrospective analysis between 1994 and 2017.

Results: Of 81 patients with imaging data, 19 (23%) had isolated adrenal involvement (iPAL), while 62 (77%) had additional extra-adrenal involvement (PAL+). Read More

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http://dx.doi.org/10.1530/EJE-19-0506DOI Listing
June 2020
4.069 Impact Factor

Stillbirth in women with diabetes: a retrospective analysis of fetal autopsy reports.

J Matern Fetal Neonatal Med 2020 Jun 21:1-8. Epub 2020 Jun 21.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Diabetes in pregnancy is associated with an increased rate of stillbirth. There are a wide variety of factors that have been implicated including placental insufficiency, hypoxia, hyperinsulinemia and impaired cardiac function. Furthermore, there is evidence that diabetic pregnancies have an increased rate of fetal cardiomyopathy as compared to non-diabetic pregnancies. Read More

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http://dx.doi.org/10.1080/14767058.2020.1779213DOI Listing

Takotsubo Cardiomyopathy Secondary to Adrenal Insufficiency: A Case Report and Literature Review.

Case Rep Cardiol 2020 7;2020:6876951. Epub 2020 Jun 7.

Department of Cardiology, University of Toledo Medical Center, Toledo, Ohio, USA.

We report a case of a middle-aged female who presented with altered mental status, hypotension, and hypoglycemia and was diagnosed with secondary adrenal insufficiency. She was also found to have elevated troponin I on initial evaluation with diffuse T wave inversions on electrocardiogram. Transthoracic echocardiogram revealed ejection fraction of 38% with apical akinesia. Read More

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http://dx.doi.org/10.1155/2020/6876951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298333PMC

The Hidden Link Between Adrenal Insufficiency and Bile Acid Homeostasis.

Am J Med 2020 Jun 19. Epub 2020 Jun 19.

Division of Geriatric Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore; Department of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.amjmed.2020.04.042DOI Listing

Adrenal crises in older patients.

Lancet Diabetes Endocrinol 2020 07;8(7):628-639

Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Adrenal crises are severe manifestations of adrenal insufficiency that result in hospital admission and incur a risk of cardiovascular events, acute renal injury, and death. Evidence from population-based studies indicate that adults older than 60 years have the highest adrenal insufficiency incidence, contribute to the highest number of adrenal crises, and have the highest age-specific incidence of adrenal crisis, which doubles between the age groups of 60-69 years and 80 years or older. Older patients might be more susceptible to adrenal crises because of a higher prevalence of comorbidities and a consequently higher risk of acute illness. Read More

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http://dx.doi.org/10.1016/S2213-8587(20)30122-4DOI Listing

APECED-Associated Hepatitis: Clinical, Biochemical, Histological and Treatment Data from a Large Predominantly American Cohort.

Hepatology 2020 Jun 17. Epub 2020 Jun 17.

Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA.

Background & Aims: Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), caused by autoimmune regulator (AIRE) mutations, manifests with chronic mucocutaneous candidiasis (CMC) and multisystem autoimmunity, most often hypoparathyroidism (HP) and adrenal insufficiency (AI). European cohorts previously reported a ~10% prevalence of APECED-associated hepatitis (APAH) with presentations ranging from asymptomatic laboratory derangements to fatal fulminant hepatic failure. Herein, we characterized APAH in a large APECED cohort from the Americas. Read More

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http://dx.doi.org/10.1002/hep.31421DOI Listing

Prader-Willi syndrome: endocrine manifestations and management.

Arch Endocrinol Metab 2020 May-Jun;64(3):223-234

Ambulatório de Prader-Willi, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brasil.

Prader-Willi syndrome (PWS) is a genetic disorder caused by the absence of gene expression in the 15q11.2-q13 paternal chromosome. Patients with PWS develop hypothalamic dysfunction that can lead to various endocrine changes such as: obesity, growth hormone deficiency, hypogonadism, hypothyroidism, adrenal insufficiency and low bone mineral density. Read More

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http://dx.doi.org/10.20945/2359-3997000000248DOI Listing

Adrenal Insufficiency and Glucocorticoid Use During the COVID-19 Pandemic.

Clinics (Sao Paulo) 2020 12;75:e2022. Epub 2020 Jun 12.

Unidade de Suprarrenal & Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular (LIM/42), Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

The coronavirus disease 2019 (COVID-19) is an emerging pandemic challenge. Acute respiratory distress syndrome (ARDS) in COVID-19 is characterized by a severe cytokine storm. Patients undergoing glucocorticoid (GC) replacement therapy for adrenal insufficiency (AI) represent a highly vulnerable group that could develop severe complications due to the SARS-CoV-2 infection. Read More

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http://dx.doi.org/10.6061/clinics/2020/e2022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279638PMC

Incidence, Predictors, Causes, and Cost of 30-Day Hospital Readmission in Chronic Obstructive Pulmonary Disease Patients Undergoing Bronchoscopy.

Cureus 2020 Jun 13;12(6):e8607. Epub 2020 Jun 13.

Pulmonary Medicine, Interfaith Medical Center, Brooklyn, USA.

Introduction Chronic obstructive pulmonary disease (COPD) has a significant disease burden and is among the leading causes of hospital readmissions, adding a significant burden on healthcare resources. The association between 30-day readmission in a COPD patient undergoing bronchoscopy and a wide range of modifiable potential risk factors, after adjusting for sociodemographic and clinical factors, has been assessed, and comparison has been made with COPD patients not undergoing bronchoscopy. Methods We conducted a comprehensive analysis of the 2016 Nationwide Readmission Database (NRD) of 30-day all-cause readmission among COPD patients undergoing bronchoscopy. Read More

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http://dx.doi.org/10.7759/cureus.8607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294856PMC

Adrenal Insufficiency Secondary to Bilateral Adrenal Hemorrhage: A Case Report.

Cureus 2020 Jun 13;12(6):e8596. Epub 2020 Jun 13.

Diabetes and Endocrinology, Peterborough City Hospital, Peterborough, GBR.

Acute adrenal hemorrhage (adrenal apoplexy) in the context of severe sepsis is potentially life-threatening. Diagnosis of this condition is difficult to achieve without a strong sense of suspicion. The concurrent use of anticoagulants increases the risk of adrenal hemorrhage in the context of sepsis. Read More

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http://dx.doi.org/10.7759/cureus.8596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294864PMC

A Remarkable Response of Granulomatous Hypophysitis to Infliximab in a Patient With a Background of Crohn's Disease-A Case Report.

Front Endocrinol (Lausanne) 2020 29;11:350. Epub 2020 May 29.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, United States.

Hypophysitis is primary or idiopathic or secondary to another disease process. The histologic subtypes of hypophysitis are lymphocytic, granulomatous, xanthomatous, xanthogranulomatous, or IgG4-related. Granulomatous hypophysitis is the second most common form and is characterized by multinucleated giant cells with granulomas and histiocytes. Read More

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http://dx.doi.org/10.3389/fendo.2020.00350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272571PMC

Adrenal function following ACTH therapy for infantile spasms: A retrospective study.

Clin Neurol Neurosurg 2020 May 12;195:105901. Epub 2020 May 12.

Department of Pediatrics, Soroka University Medical Center, Beer-Sheva, Israel; Pediatric Endocrinology Unit, Soroka University Medical Center, Beer-Sheva, Israel.

Objective: To determine if treatment with ACTH for infantile spasms (IS) is associated with secondary adrenal insufficiency.

Patients And Methods: This is a retrospective study of patients diagnosed with infantile spasms and treated with ACTH between 2007 and 2018 at Soroka University Medical Center (SUMC). We reviewed the records of patients who had a post-hormonal laboratory assessment of their adrenal function; either a low dose ACTH test or a random morning cortisol level and looked for laboratory or clinical signs of adrenal insufficiency. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105901DOI Listing

[Hypopituitarism].

Gan To Kagaku Ryoho 2020 Jun;47(6):885-890

Dept. of Medical Oncology, Toranomon Hospital.

In recent years, the role ofimmune checkpoint inhibitors(ICIs)has become crucial in cancer therapy. However, ICIs are known to trigger a wide variety of autoimmune side effects, termed immune-related adverse events(irAEs), which can influence multiple organs. Hypophysitis induced by ICIs, which is defined as the inflammation of the pituitary gland and is the cause ofhypopituitarism, is one ofthe important toxicities, because it can be life-threatening event when it is not diagnosed or managed properly. Read More

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Understanding the cholesterol and cytokine network in patients with adrenal insufficiency and cirrhosis.

Authors:
Sujoy Khan

J R Coll Physicians Edinb 2020 Mar;50(1):92-95

Department of Immunology and Allergy, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Cottingham, UK,

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http://dx.doi.org/10.4997/JRCPE.2020.126DOI Listing

Triple-A Syndrome (TAS): an in-depth overview on genetic and phenotype heterogeneity.

Protein Pept Lett 2020 Jun 13. Epub 2020 Jun 13.

Lab of Endocrine and Metabolic Research, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Milan. Italy.

Triple-A Syndrome (TAS) is a rare autosomal recessive disorder characterized by three cardinal symptoms: alacrimia, achalasia and adrenal insufficiency due to ACTH insensitivity. Various progressive neurological abnormalities and skin changes have been described in association with the syndrome. The disease is caused by mutation in the AAAS gene on chromosome 12q13. Read More

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http://dx.doi.org/10.2174/0929866527666200613215449DOI Listing

BILATERAL ADRENAL HEMORRHAGE WITH ADRENAL INSUFFICIENCY AFTER DALTEPARIN USE POST HIP ATHROPLASTIES.

AACE Clin Case Rep 2020 May-Jun;6(3):e141-e143. Epub 2020 May 8.

Objective: Multiple case reports have implicated the use of heparin for deep vein thrombosis (DVT) prophylaxis with bilateral adrenal hemorrhage. Only 1 previous report has described this with the low molecular weight product, dalteparin. We report a case following bilateral hip arthroplasties. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282283PMC

ADRENAL INSUFFICIENCY SECONDARY TO BILATERAL ADRENAL HEMORRHAGE ASSOCIATED WITH ANTIPHOSPHOLIPID SYNDROME.

AACE Clin Case Rep 2020 Mar-Apr;6(2):e65-e69. Epub 2019 Dec 20.

Objective: Antiphospholipid syndrome (APS) can involve multiple organ systems but endocrine manifestations are rare. In most cases adrenal insufficiency (AI) is the first endocrine manifestation of APS. The prompt diagnosis of AI is critical as this disorder is a life-threatening disease that may lead to fatal outcomes if left untreated. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282157PMC
December 2019

PRIMARY ADRENAL INSUFFICIENCY SECONDARY TO CHRONIC POSACONAZOLE USE.

AACE Clin Case Rep 2020 Mar-Apr;6(2):e62-e64. Epub 2020 Mar 4.

Objective: Posaconazole (PSO) is commonly used in the treatment of invasive fungal infections. PSO-induced primary adrenal insufficiency (PAI) is rare, and we present what we think to be the third case report of its incidence. We want to bring awareness to this rare but significant side effect that can impact management and monitoring of patients on this medication. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282156PMC

RECURRENT INVASIVE DUCTAL BREAST CARCINOMA PRESENTING AS PRIMARY ADRENAL INSUFFICIENCY WITH ADRENAL CRISIS.

AACE Clin Case Rep 2020 Mar-Apr;6(2):e50-e53. Epub 2020 Mar 4.

Objective: We report the first case of recurrent ductal breast carcinoma presenting as primary adrenal insufficiency.

Methods: We describe a patient who developed a recurrence of invasive ductal breast carcinoma which went undetected until the patient presented with fulminant adrenal crisis. We describe here an overview of the clinical presentation, work-up, diagnosis, and treatment of adrenal crisis. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282154PMC

Managing common endocrine disorders amid COVID-19 pandemic.

Diabetes Metab Syndr 2020 Jun 4;14(5):767-771. Epub 2020 Jun 4.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. Electronic address:

Background And Aims: The novel coronavirus disease (COVID-19) pandemic and the resulting nationwide lockdowns have posed a major challenge to the management of pre-existing and newly diagnosed endocrine disorders. Herein, we have summarized the management approaches of common endocrine disorders amid the ongoing pandemic.

Methods: We have performed an extensive literature search for articles in PubMed, EMBASE and Google Scholar databases till 25 May 2020, with the following keywords: "COVID-19", "diabetes mellitus", "thyroid disorders", "primary adrenal insufficiency", "Cushing's syndrome", "pituitary tumors", "vitamin D″", "osteoporosis", "primary hyperparathyroidism", "hypoparathyroidism", "management", "treatment" and "guidelines" with interposition of the Boolean operator "AND". Read More

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http://dx.doi.org/10.1016/j.dsx.2020.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271862PMC

Partial empty sella syndrome, GH deficiency and transient central adrenal insufficiency in a patient with NF1.

Endocrine 2020 Jun 9. Epub 2020 Jun 9.

Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Athens, Greece.

Purpose: To describe the case of a 9-year-old male patient with neurofibromatosis type 1 (NF1), partial empty sella (PES), transient central adrenal insufficiency (CAI) and growth hormone (GH) deficiency (GHD) treated with recombinant GH (rGH).

Methods: The diagnosis of GHD was established upon peak GH response <10 ng/mL following glucagon and clonidine stimulation tests. CAI was diagnosed when peak cortisol response was <18 μg/dL following 1 μg Synacthen test (ST) with normal ACTH levels. Read More

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http://dx.doi.org/10.1007/s12020-020-02351-zDOI Listing

Systemic steroids in patients with COVID-19: pros and contras, an endocrinological point of view.

J Endocrinol Invest 2020 Jun 8. Epub 2020 Jun 8.

Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.

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http://dx.doi.org/10.1007/s40618-020-01325-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279635PMC

Single-institutional outcome-analysis of low-dose stereotactic body radiation therapy (SBRT) of adrenal gland metastases.

BMC Cancer 2020 Jun 8;20(1):536. Epub 2020 Jun 8.

Department of Radiation Oncology, Technical University of Munich (TUM), Ismaninger Straße 22, Munich, Germany.

Background: Adrenal gland metastases are a common diagnostic finding in various tumor diseases. Due to the increased use of imaging methods, they are diagnosed more frequently, especially in asymptomatic patients. SBRT has emerged as a new, alternative treatment option in the field of radiation oncology. Read More

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http://dx.doi.org/10.1186/s12885-020-07030-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282163PMC

Ectopic adrenal gland in an adult inguinal hernial sac: A case report.

Int J Surg Case Rep 2020 May 30;72:66-68. Epub 2020 May 30.

Mount Lebanon Hospital, Mount Lebanon, Lebanon. Electronic address:

Introduction: A 37-year-old male patient operated for inguinal hernia repair was found to have ectopic adrenocortical tissue in the hernial sac.

Case Presentation: A 37-year-old man was admitted for bilateral inguinal hernia. An uneventful open repair was done, and the resected hernial sacs were sent to pathology. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281308PMC