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    Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).
    Platelets 2017 Jul 20:1-3. Epub 2017 Jul 20.
    b McAllister Heart Institute , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina , USA.
    Congenital platelet function disorders are often the result of defects in critical signal transduction pathways required for platelet adhesion and clot formation. Mutations affecting RASGRP2, the gene encoding the Rap GTPase activator, CalDAG-GEFI, give rise to a novel, and rare, group of platelet signal transduction abnormalities. We here report platelet function studies for two brothers (P1 and P2) expressing a novel variant of RASGRP2, CalDAG-GEFI(p. Read More

    Duodenal hematoma caused by endoscopic hemostatic procedures (sclerotherapy).
    Rev Esp Enferm Dig 2017 Jul 10;109. Epub 2017 Jul 10.
    Servicio de Aparato Digestivo A, Complejo Hospitalario de Navarra, España.
    Endoscopic hemostatic procedures such as local injection of epinephrine are commonly used for the treatment of bleeding ulcers. Although the risks are usually considered to be minimal, there are reports describing that duodenal intramural hematomas may develop as a complication after endoscopy especially in patients susceptible to hemorrhage such as those with anticoagulants therapy or blood dyscrasia. Read More

    Metachronous bilateral adrenal hemorrhage in primary antiphospholipid syndrome.
    Med Clin (Barc) 2017 Jun 26. Epub 2017 Jun 26.
    Servicio de Endocrinología y Nutrición, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, España; Universidad de Barcelona, Barcelona, España.

    BIlateral juxtapapillary retinal capillary haemangioma: Usefulness of aflibercept in the management of its complications.
    Arch Soc Esp Oftalmol 2017 Jun 23. Epub 2017 Jun 23.
    Servicio de Oftalmología, Hospital Virgen del Puerto, Plasencia (Cáceres), España.
    Case Report: A 45 year-old man with a history of adrenal phaeochromocytoma presented with a subretinal juxtapapillary haemorrhage on his left eye and a small asymptomatic vascular tumour in the contralateral eye. With the mentioned findings, the patient was diagnosed with bilateral retinal capillary haemangioma in the context of a von Hippel Lindau disease. Intravitreal aflibercept was prescribed, with a good outcome of the disease. Read More

    Data-mining for detecting signals of adverse drug reactions of fluoxetine using the Korea Adverse Event Reporting System (KAERS) database.
    Psychiatry Res 2017 Jun 13;256:237-242. Epub 2017 Jun 13.
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. Electronic address:
    Selective serotonin reuptake inhibitors (SSRIs) have become one of the most broadly used medications in psychiatry. Fluoxetine is the first representative antidepressant SSRI drug approved by the Food and Drug Administration (FDA) in 1987. Safety information on fluoxetine use alone was less reported than its combined use with other drugs. Read More

    Differences between Takotsubo cardiomyopathy and reverse Takotsubo cardiomyopathy associated with subarachnoid hemorrhage.
    Int J Cardiol Heart Vasc 2016 Jun 11;11:99-103. Epub 2016 May 11.
    Department of Neurosurgery, Fujita Health University Hospital, Toyoake, Japan.
    Background: Both Takotsubo cardiomyopathy (TTC) and reverse TTC (r-TTC) are characterized by reversible regional wall motion abnormalities of the heart unrelated to coronary artery pathology. It remains unclear whether and/or how r-TTC differs from TTC. Subarachnoid hemorrhage (SAH) is occasionally causative of TTC/r-TTC, and this study was conducted to detect possible differences between TTC and r-TTC associated with SAH. Read More

    A case of acute Sheehan's syndrome and literature review: a rare but life-threatening complication of postpartum hemorrhage.
    BMC Pregnancy Childbirth 2017 Jun 14;17(1):188. Epub 2017 Jun 14.
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
    Background: Sheehan's syndrome occurs because of severe postpartum hemorrhage causing ischemic pituitary necrosis. Sheehan's syndrome is a well-known condition that is generally diagnosed several years postpartum. However, acute Sheehan's syndrome is rare, and clinicians have little exposure to it. Read More

    Tranexamic acid plus diluted-epinephrine versus tranexamic acid alone for blood loss in total joint arthroplasty: A meta-analysis.
    Medicine (Baltimore) 2017 Jun;96(24):e7095
    aDepartment of Traumatology, Linyi People's Hospital bDepartment of Surgery; Feixian people's Hospital, Linyi, Shandong, China.
    Background: We conducted the present meta-analysis to assess the efficacy and safety of tranexamic acid (TXA) plus diluted-epinephrine (DEP) for patients with total joint arthroplasty (TJA, including total knee arthroplasty (TKA) and total hip arthroplasty (THA)).

    Methods: Electronic databases (PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Wanfang databases, and Google databases) were systematically searched up to December 2016. Only randomized controlled trials (RCTs) were included. Read More

    Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis.
    Shock 2017 Jun 6. Epub 2017 Jun 6.
    *Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX †Department of Surgery, McGovern Medical School, University of Texas Health Science Center, Houston, TX ‡Capital Region Blood Bank, Rigshospitalet, Copenhagen, Denmark §Department of Pathology & Laboratory Medicine, University of California San Francisco, San Francisco, CA ||Blood Systems Research Institute, San Francisco, CA ¶Department of Surgery, Oregon Health & Science University, Portland, OR.
    Background: The paradigm shift from crystalloid to plasma resuscitation of traumatic hemorrhagic shock has improved patient outcomes due in part to plasma-mediated reversal of catecholamine and inflammation-induced endothelial injury, decreasing vascular permeability and attenuating organ injury. Since sepsis induces a similar endothelial injury as seen in hemorrhage, we hypothesized that plasma resuscitation would increase 48-hour survival in a rat sepsis model.

    Methods: Adult male Sprague-Dawley rats (375-425 g) were subjected to 35% cecal ligation and puncture (CLP) (t = 0 h). Read More

    Perimortem Demonstration and Treatment of Recipient-to-Donor Transfusion in Monochorionic-Diamniotic Twin Gestation.
    Fetal Diagn Ther 2017 Jun 2. Epub 2017 Jun 2.
    KU Center for Advanced Fetal Care, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, KS, USA.
    Twin-twin transfusion syndrome is a complication of monochorionic-diamniotic placentation. Should one twin die, ≈30% of co-twins will also die, and if they survive, ≈30% experience severe morbidity rates, each believed secondary to hemorrhage of the co-twin into the deceased twin. We report apparently the first ultrasound-documented case of perimortem hemorrhage in twin-twin transfusion syndrome and its treatment by emergent ultrasound-guided percutaneous cord occlusion followed by percutaneous fetal intravascular transfusion. Read More

    A case of stiff-person syndrome due to secondary adrenal insufficiency.
    Rinsho Shinkeigaku 2017 Jun 26;57(6):298-302. Epub 2017 May 26.
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University.
    We report a case of flexion contractures in a patient's legs secondary to postpartum hypopituitarism. A 56-year-old woman presented with a 3-year history of worsening flexion contractures of the hips and knees. On admission, her hips and knees could not be extended, and she had muscle stiffness and tenderness to palpation of the lower extremities. Read More

    Comparison of the efficacy and safety of 2% lidocaine HCl with different epinephrine concentration for local anesthesia in participants undergoing surgical extraction of impacted mandibular third molars: A multicenter, randomized, double-blind, crossover, phase IV trial.
    Medicine (Baltimore) 2017 May;96(21):e6753
    aDepartment of Dental Anesthesiology bDepartment of Dental Anesthesiology and Dental Research Institute, Seoul National University School of Dentistry cDepartment of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul dDepartment of Dental Anesthesiology, Dankook University College of Dentistry, Dankook University, Cheonan-si, Chungnam eDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University and Institute of Translational Dental Sciences, Pusan National University fDepartment of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University and Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Gyeongnam gCollege of Dentistry, Wonkwang University, Iksan city, Jeonbuk hDepartment of Oral and Maxillofacial Surgery, Dankook University College of Dentistry, Dankook University, Cheonan-si, Chungnam iDepartment of Oral & Maxillofacial Surgery, Kyung Hee University Dental Hospital Kyung Hee University School of Dentistry, Seoul jR&D Center, Huons Co. Ltd., College of Pharmacy, Hanyang University, Ansan-si, Kyeonggi-do, Republic of Korea.
    Background: The most commonly impacted tooth is the third molar. An impacted third molar can ultimately cause acute pain, infection, tumors, cysts, caries, periodontal disease, and loss of adjacent teeth. Local anesthesia is employed for removing the third molar. Read More

    Adrenal obliteration by balloon-occluded retrograde venous ethanol injection in a swine model.
    Minim Invasive Ther Allied Technol 2017 May 19:1-9. Epub 2017 May 19.
    a Department of Radiology , Shiga University of Medical Science , Shiga , Japan.
    Purpose: To evaluate the effects of adrenal obliteration by balloon-occluded retrograde venous ethanol injection.

    Material And Methods: We inserted a micro-balloon catheter into the left adrenal vein of six pigs and retrogradely injected absolute ethanol (0.06 ml/kg) under balloon occlusion. Read More

    Development of intracerebral hemorrhage in the short-term clinical course of a patient with microscopic polyangiitis without neurological symptoms at diagnosis: an autopsy case.
    CEN Case Rep 2016 Nov 5;5(2):173-178. Epub 2016 Apr 5.
    Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama City, 700-8558, Japan.
    A 77-year-old man with high-grade fever, progressive renal dysfunction, high serum level of C-reactive protein and positive serum myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) was diagnosed with microscopic polyangiitis with rapidly progressive glomerulonephritis, and remission induction treatment with glucocorticoids and intravenous cyclophosphamide was initiated. Although his general condition improved in a short time, intracerebral hemorrhage occurred 12 days after the initiation of treatment and emergent hematoma evacuation was performed. However, he passed away on day 14. Read More

    Two Cases of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with High Serum Procalcitonin Levels, Including the First Case Complicated with Adrenal Hemorrhaging.
    Intern Med 2017 15;56(10):1247-1252. Epub 2017 May 15.
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
    Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis/Renal failure, and Organomegaly (TAFRO) syndrome is a recently described systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly. It has an acute or subacute onset of unknown etiology, although some pathological features resemble those of multicentric Castleman disease. We here report two cases of TAFRO syndrome. Read More

    TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-label, Non-randomized Phase 1 Study.
    Cancer Res Treat 2017 May 10. Epub 2017 May 10.
    Department of Experimental Therapeutics, National Cancer Center Hospital East, Chiba, Japan.
    Purpose: This phase 1 dose-escalation portion of the study evaluated the safety, pharmacokinetics (PK), and antitumor activity of TAK-264 in Asian patients with advanced gastrointestinal (GI) carcinoma or metastatic or recurrent gastric or gastroesophageal junction adenocarcinoma expressing guanylyl cyclase C (GCC).

    Materials And Methods: Adult patients with advanced GI malignancies expressing GCC (H-score ≥ 10) received TAK-264 on day 1 of 3-week cycles as 30-minute intravenous infusions for up to 1 year or until disease progression or unacceptable toxicity. The primary objectives were to evaluate the safety profile including dose-limiting toxicities (DLTs) during cycle 1, determine the maximum tolerated dose (MTD), and characterize the PK profile of TAK-264 (NCT02391038). Read More

    Epinephrine-Induced Takotsubo Cardiomyopathy During Laparoscopic Myomectomy: Case Report and Review of the Literature.
    J Minim Invasive Gynecol 2017 May 6. Epub 2017 May 6.
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Riad El-Solh, Beirut, Lebanon.
    Laparoscopic myomectomy, a minimally invasive procedure performed for the management of uterine leiomyomas, involves a challenging aspect: excessive local bleeding. Hemorrhage control during laparoscopic myomectomy can be achieved through the use of a wide range of vasoconstrictors, including epinephrine. Epinephrine is frequently used for the control of local bleeding during surgery; however, it has been associated with several complications. Read More

    Clinical Characteristics and Current Interventions in Shock Patients in Chinese Emergency Departments: A Multicenter Prospective Cohort Study.
    Chin Med J (Engl) 2017 May;130(10):1146-1154
    Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China.
    Background: Shock is a life-threatening condition in emergency departments (EDs) and is associated with a high mortality; however, its clinical characteristics and current interventions in China are seldom reported. This study investigated the clinical characteristics and current interventions of shock patients in Chinese EDs.

    Methods: This multicenter prospective cohort study was conducted in the EDs of 33 academic hospitals in 16 Chinese provinces. Read More

    The efficacy and safety of epinephrine for postoperative bleeding in total joint arthroplasty: A PRISMA-compliant meta-analysis.
    Medicine (Baltimore) 2017 Apr;96(17):e6763
    Biomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Tianjin, PR China.
    Background: Total joint arthroplasty (TJA) usually results in postoperative bleeding. Some randomized controlled trials (RCTs) and nonrandomized controlled trials (non-RCTs) have been performed to evaluate the effects of epinephrine on postoperative bleeding after TJA. However, this remained controversial about the efficacy and safety of epinephrine for postoperative bleeding in TJA. Read More

    Spontaneous Adrenal Hemorrhage in Pregnancy: A Case Series.
    Case Rep Obstet Gynecol 2017 22;2017:3167273. Epub 2017 Mar 22.
    Department of Obstetrics and Gynecology, Crozer Chester Medical Center, One Medical Center Boulevard, Upland, PA 19013, USA.
    Background. Abdominal pain during pregnancy has a broad differential diagnosis which includes spontaneous adrenal hemorrhage (SAH). There is scant literature available on optimal mode of delivery in stable patients. Read More

    Cardiopulmonary resuscitation of out-of-hospital traumatic cardiac arrest in Qatar: A nationwide population-based study.
    Int J Cardiol 2017 Aug 30;240:438-443. Epub 2017 Mar 30.
    Department of Medicine Solna, 171 00, Karolinska Institutet, Sweden. Electronic address:
    Background: Traumatic cardiac arrest studies have reported improved survival rates recently, ranging from 1.7-7.5%. Read More

    Preoperative adrenal artery embolization followed by surgical excision of giant hypervascular adrenal masses: report of three cases.
    Acta Chir Belg 2017 Apr 7:1-7. Epub 2017 Apr 7.
    a Istanbul Faculty of Medicine, General Surgery Department , Istanbul University , Istanbul , Turkey.
    Background: Transcatheter arterial embolization (TAE) is an effective minimally invasive adjunct to surgery for the management and/or palliation of adrenal tumors.

    Methods: In this case study, we reported three patients who underwent preoperative TAE before adrenalectomy for large hypervascular adrenal tumors. All patients underwent preoperative embolization 24 h before the operation and were then followed up at the intensive care unit surgery. Read More

    Postural Syncope and Constipation: An Unusual Presentation of a Duodenal Dieulafoy's Lesion.
    Case Rep Gastrointest Med 2017 7;2017:6983434. Epub 2017 Mar 7.
    Department of Internal Medicine, Seton Hall University School of Health and Medical Sciences, Saint Francis Medical Center, Trenton, NJ, USA.
    Dieulafoy lesions are a rare etiology of gastrointestinal bleeding from a large caliber-persistent tortuous submucosal artery. They account for 1-2% of all causes of acute gastrointestinal hemorrhage with 80%-95% of these lesions located in the stomach along the lesser curvature. One-third of these lesions present at an extragastric location, with the proximal duodenum accounting for 15% of them. Read More

    Exposure to any antenatal corticosteroids and outcomes in preterm infants by gestational age: prospective cohort study.
    BMJ 2017 Mar 28;356:j1039. Epub 2017 Mar 28.
    Division of Neonatology, University of Alabama at Birmingham, AL 35233, USA.
    Objective To determine whether exposure to any antenatal corticosteroids is associated with a lower rate of death at each gestational age at which administration is currently recommended.Design Prospective cohort study.Settings 300 participating neonatal intensive care units of the Pediatrix Medical Group in the United States. Read More

    Adrenal Histologic Stress-related Changes in Third Trimester Stillbirth.
    Pediatr Dev Pathol 2017 Mar-Apr;20(2):112-119. Epub 2017 Jan 25.
    1 Department of Pathology, Hutzel Women's Hospital and Harper University Hospital, Wayne State University School of Medicine, Detroit, Michigan, USA.
    Adrenal histologic changes, including compact cell change (CCC), cystic change (CYC), and adrenal hemorrhage (AH), and their clinical correlations have only infrequently been investigated in stillbirth. We evaluated 75 third trimester singleton stillborns with complete autopsies (30 term and 45 preterm). A total of 58 had unexplained stillbirth and 17 had clinical placental abruption. Read More

    Chronic Subdural Hematoma ICU Management.
    Neurosurg Clin N Am 2017 Apr;28(2):239-246
    Departments of Neurosurgery and Neurology, Division of Neurocritical Care McGovern Medical School, 6431 Fannin Street, Medical School Building 7.152, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:
    Patients with cSDH presenting with new or worsening neurological deficits, especially if they are debilitating and adversely affecting quality of life require urgent medical and surgical attention. Neurological and neurosurgical critical care team need to stabilize the patient by reversing any underlying coagulopathy states in order to prevent further hematoma expansion.In the event of brain herniation and presumed ICP elevation and CPP compromise, step-wise ICP management should be instituted promptly. Read More

    Chronic Subdural Medical Management.
    Neurosurg Clin N Am 2017 Apr 1;28(2):211-217. Epub 2017 Feb 1.
    Department of Neurology, Columbia University Medical Center, 177 Fort Washington Avenue, Milstein Building 8GS-300, New York, NY 10032, USA.
    Chronic subdural hematomas (cSDHs) that are asymptomatic or have minimal symptoms have become more prevalent, with an increased rate of detection with neuroimaging in the setting of an aging population and increasing use of anticoagulants. These cSDHs have been known to spontaneously resolve, and subsequent efforts have been made to study the role of nonoperative initial medical management strategies in these patients. Current and potential strategies for the medical management of cSDH are discussed. Read More

    Characteristics and outcomes of very low birth weight infants receiving epinephrine during delivery room resuscitation.
    Resuscitation 2017 Jun 18;115:1-4. Epub 2017 Mar 18.
    Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Memphis, TN, USA; OB/GYN, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:
    Background: Delivery room resuscitation of very low birth weight infants can involve use of endotracheal or intravenous epinephrine. Data of the past 19 years were reviewed to identify the usage of epinephrine in delivery room and identify characteristics of these babies.

    Methods: Neonates with ≤1500g birthweight from January 1996 to August 2014 were reviewed. Read More

    Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
    Cochrane Database Syst Rev 2017 03 21;3:CD004454. Epub 2017 Mar 21.
    Liggins Institute, The University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.
    Background: Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed. Read More

    Conservative Treatment for Idiopathic Adrenal Hemorrhage Tracked by a Long-term Series of CT Images.
    Intern Med 2017 17;56(6):673-676. Epub 2017 Mar 17.
    Department of Endocrinology and Diabetes, National Hospital Organization, Nagoya Medical Center, Japan.
    A 55-year-old man was transported to our hospital after a sudden onset of left lower abdominal pain while driving. Computed tomography (CT) of the abdominal region revealed an extensive iso-intense signal region that had a maximum area of 14×15 cm, which we treated conservatively. A series of follow-up CT images showed the gradual decrease of the left peritoneal mass, while continuity with the left adrenal gland became apparent. Read More

    Bilateral adrenal hemorrhage in the background of Escherichia coli sepsis: a case report.
    J Med Case Rep 2017 Mar 17;11(1):72. Epub 2017 Mar 17.
    St Helier Hospital, Wrythe Lane, Carshalton, SM5 1AA, UK.
    Background: Sepsis is a syndrome of life-threatening organ dysfunction caused by a dysregulated host response to infection. It can have devastating consequences, including bilateral adrenal hemorrhage, particularly in patients at high thrombotic risk, such as those with antiphospholipid syndrome and those on long-term anticoagulation.

    Case Presentation: A 49-year-old white woman re-presented to hospital with a history suggestive of sepsis. Read More

    Long-term safety of once-daily, dual-release hydrocortisone in patients with adrenal insufficiency: a phase 3b, open-label, extension study.
    Eur J Endocrinol 2017 Jun 14;176(6):715-725. Epub 2017 Mar 14.
    Department of EndocrinologySahlgrenska University Hospital and Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Objective: To investigate the long-term safety and tolerability of a once-daily, dual-release hydrocortisone (DR-HC) tablet as oral glucocorticoid replacement therapy in patients with primary adrenal insufficiency (AI).

    Design: Prospective, open-label, multicenter, 5-year extension study of DR-HC conducted at five university clinics in Sweden.

    Methods: Seventy-one adult patients diagnosed with primary AI who were receiving stable glucocorticoid replacement therapy were recruited. Read More

    Estrogen receptors ERα and ERβ participation in hypothalamus-pituitary-adrenal axis activation by hemorrhagic stress.
    Neuroscience 2017 May 6;349:239-252. Epub 2017 Mar 6.
    Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto - SP, Brazil. Electronic address:
    The sympato-adrenal-system and hypothalamus-pituitary-adrenal (HPA) axis are anatomically and functionally connected with participation of several brain areas that express estrogen receptors (ERα and ERβ). We assessed the neuronal activity of these areas for FOS expression and the action of PPT (ERα agonist) or DPN (ERβ agonist) in HPA axis activity during hemorrhagic stress. Ovariectomized Wistar rats treated with vehicle (DMSO) or ER agonists were catheterized for blood collection. Read More

    Anterior Transabdominal Laparoscopic Adrenalectomy, without Ligatures, for a Symptomatic Right Adrenal Myelolipoma with Intratumoral Hemorrhage.
    Chirurgia (Bucur) 2017 Jan-Feb;112(1):58-62
    Myelolipomas represent 3-7% fromthe primary tumors of the adrenal gland. Most often they are incidental findings. In most cases are asymptomatic, rarely they present symptoms (pain, abdominal discomfort, hematuria or signs of internal hemorrhage). Read More

    Cystic adrenal lesions: focus on pediatric population (a review).
    Clujul Med 2017 15;90(1):5-12. Epub 2017 Jan 15.
    Endocrinology Department, Iuliu Hatieganu University of Medicine and Pharmacy & Clinical County Hospital, Cluj-Napoca, Romania.
    Background And Aim: The cysts may potentially affect any organ; adrenals cysts are rare. This is a review of the literature regarding adrenal cysts, focusing on children and young adults.

    General Data: Three major types have been described: pure cysts (endothelial, epithelial, and hemorrhagic or pseudocyst), parasitic (as hydatid) cysts and cystic part of a tumour (most frequent are neuroblastoma, ganglioneuroma, pheocromocytoma, and teratoma). Read More

    Tension pneumomediastnum: A rare cause of acute intraoperative circulatory collapse in the setting of unremarkable TEE findings.
    J Clin Anesth 2017 Feb 12;37:136-138. Epub 2017 Jan 12.
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:
    Design: Case report.

    Setting: Operating room.

    Patient: 25YF, ASA IV E who underwent an emergent decompressive craniectomy for refractory intracranial hypertension secondary to acute intracranial hemorhage. Read More

    Delayed hemorrhage effect of local anesthesia with epinephrine in the loop electrosurgical excisional procedure.
    Obstet Gynecol Sci 2017 Jan 19;60(1):87-91. Epub 2017 Jan 19.
    Institute of Women's Life Medical Science, Women's Cancer Clinic, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
    Objective: The aim of this study was to investigate factors preventing delayed hemorrhage after the loop electrosurgical excisional procedure (LEEP).

    Methods: Medical records of patients who underwent LEEP at one university affiliated hospital from October 2013 to January 2015 were reviewed. Patients with or without delayed hemorrhage were classified. Read More

    Imaging of unilateral adrenal hemorrhages in patients after blunt abdominal trauma: Report of two cases.
    Chin J Traumatol 2017 Feb 19;20(1):52-55. Epub 2017 Jan 19.
    Department of Radiology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
    Adrenal hemorrhage following blunt abdominal trauma is extremely rare. Most of the lesions are unilateral and right sided. Although often asymptomatic, life-threatening adrenal insufficiency may develop in the bilateral adrenal gland hemorrhage. Read More

    Spontaneous Unilateral Adrenal Hemorrhage in Pregnancy.
    Cureus 2017 Jan 13;9(1):e977. Epub 2017 Jan 13.
    Endocrinology, University of Kansas School of Medicine-Wichita.
    Spontaneous adrenal hemorrhage (SAH) is a serious medical condition associated with variable clinical presentation depending on the extent of the hemorrhage. Pregnancy-induced adrenal hemorrhage is poorly understood. A low cortisol level in the peripartum period with radiological findings is sufficient to establish the diagnosis. Read More

    Stroke disclosing primary aldosteronism: Report on three cases and review of the literature.
    Ann Endocrinol (Paris) 2017 Feb 4;78(1):9-13. Epub 2017 Feb 4.
    Department of Neurology, Military Hospital, 1008, Montfleury, 1089 Tunis, Tunisia.
    Objectives: There is a growing evidence of increased risk of cerebrovascular events in primary aldosteronism (PA). Nevertheless, acute neurologic ailment as presenting feature of PA is uncommon. Our aim is to highlight the diagnosis challenges in stroke unmasking PA and to discuss the underlying physiopathology and management dilemmas. Read More

    A 17-Year-Old With Chest Pain.
    Pediatrics 2017 Mar 3;139(3). Epub 2017 Feb 3.
    Children's National Health System, Washington, District of Columbia; and.
    A 17-year-old male subject with a history of deep venous thrombosis presented with acute unilateral severe chest pain. His examination was nonspecific, and vital signs were normal. His initial laboratory evaluation revealed mild thrombocytopenia, elevated troponin levels, and critically elevated activated partial thromboplastin time. Read More

    Practical Approach to Adrenal Imaging.
    Radiol Clin North Am 2017 Mar 12;55(2):279-301. Epub 2016 Dec 12.
    Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1473, Houston, TX 77030, USA.
    Various pathologies can affect the adrenal gland. Noninvasive cross-sectional imaging is used for evaluating adrenal masses. Accurate diagnosis of adrenal lesions is critical, especially in cancer patients; the presence of adrenal metastasis changes prognosis and treatment. Read More

    Reassessment of Rebleeding Risk of Forrest IB (Oozing) Peptic Ulcer Bleeding in a Large International Randomized Trial.
    Am J Gastroenterol 2017 Mar 17;112(3):441-446. Epub 2017 Jan 17.
    Formerly with AstraZeneca R&D, Molndal, Sweden.
    Objectives: Our aims were to assess risks of early rebleeding after successful endoscopic hemostasis for Forrest oozing (FIB) peptic ulcer bleeding (PUBs) compared with other stigmata of recent hemorrhage (SRH).

    Methods: These were post hoc multivariable analyses of a large, international, double-blind study (NCT00251979) of patients randomized to high-dose intravenous (IV) esomeprazole (PPI) or placebo for 72 h. Rebleeding rates of patients with PUB SRH treated with either PPI or placebo after successful endoscopic hemostasis were also compared. Read More

    Pheochromocytoma Multisystem Crisis Behaving Like Interstitial Pneumonia: An Autopsy Case.
    Intern Med 2017 15;56(2):149-152. Epub 2017 Jan 15.
    Department of Cardiology, Fuchu Hospital, Japan.
    Pheochromocytoma multisystem crisis is a rare and life-threatening disease that is associated with numerous symptoms and which is also difficult to diagnose. We herein report an autopsy case of a 61-year-old man who died due to pheochromocytoma multisystem crisis. The patient complained of vomiting and breathlessness. Read More

    Dieulafoy's lesion of the oesophagus: a case series and literature review.
    BMJ Case Rep 2017 Jan 6;2017. Epub 2017 Jan 6.
    SUNY Downstate Medical Center, New York, New York, USA.
    Dieulafoy's lesion is a vascular abnormality consisting of a tortuous, dilated aberrant submucosal vessel that erodes the overlying mucosal layer without ulceration. The oesophagus is a very rare location for the lesion. Herein, we report a case series of 3 patients who presented with upper gastrointestinal bleeding. Read More

    [IgA vasculitis (Henoch-Schönlein purpura)].
    Wiad Lek 2016;69(5):711-713
    Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska.
    IgA vasculitis (Schönlein-Henoch purpura) is a systemic inflammation of the small vessels associated with the deposition of IgA antibodies in the vascular wall. Typical clinical symptoms are: skin lesions (purpura), joint pain, abdominal discomfort and renal disorder (most common haematuria/proteinuria). The disease affects usually the pediatric population; in those patients its course is benign and usually not associated with permanent complications. Read More

    A double-blind randomized prospective study comparing prilocaine versus ropivacaine in upper blepharoplasty.
    J Plast Reconstr Aesthet Surg 2017 Mar 19;70(3):375-379. Epub 2016 Nov 19.
    Department of Plastic and Reconstructive Surgery, Hospital of the Barmherzigen Brüder, Teaching hospital of the Paracelsus Medical University Salzburg, Kajetanerplatz 1, 5020 Salzburg, Austria.
    Background: Upper blepharoplasties are a common procedure in plastic surgery. This procedure can be performed effectively under local anesthesia with or without sedation. The ideal local anesthetic should cause less intraoperative bleeding and less postoperative edema. Read More

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