Search Our Scientific Publications & Authors

J Zoo Wildl Med 2022 Jun;53(2):433-441

Biomedical Diagnostic Services, Knoxville, TN 37996, USA.

This retrospective study reviews the diseases associated with morbidity and mortality in 221 budgerigars () from a captive population from 2013 to 2019. The study aimed to evaluate the health status of a flock of budgerigars typical of today's zoologic collections. Based on previous literature, it was hypothesized that age-related conditions such as neoplasia would be common, whereas metabolic and nutritional disorders would be less common. Read More

Cureus 2022 May 21;14(5):e25188. Epub 2022 May 21.

Gastroenterology, Parkview Medical Center, Pueblo, USA.

Dieulafoy lesions are common dilated submucosal vessels that can present with gastrointestinal (GI) bleeding. These lesions are usually found in the stomach or esophagus and colonic Dieulafoy lesions are very rare. Clinical presentation can vary from mild non-threatening GI bleeding to massive and recurrent hemorrhage. Read More

In Vivo 2022 Jul-Aug;36(4):1777-1784

Department of Gynecology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Background/aim: We investigated the impact of the timing of antenatal corticosteroid (ACS) administration on the clinical outcome of preterm infants.

Patients And Methods: Two hundred and fifty-five preterm infants between 28+0 and 34+0 weeks of gestation were retrospectively assigned to one of two groups: In the first group, ACS was given within 7 days before birth; the second group, did not receive ACS during that period. The primary outcome parameter was respiratory failure (defined by need for continuous positive airway pressure or mechanical ventilation) due to grade 1-4 respiratory distress syndrome (RDS). Read More

Front Physiol 2022 6;13:924908. Epub 2022 Jun 6.

Department of Anesthesiology, University of Vermont Larner College of Medicine, Burlington, VT, United States.

Preeclampsia is a hypertensive disorder of pregnancy that causes significant, long term cardiovascular effects for both the mother and offspring. A previous study demonstrated that middle cerebral arteries in offspring from an experimental rat model of preeclampsia were smaller, stiffer, and did not enlarge over the course of maturation, suggesting potential hemodynamic alterations in these offspring. Here we investigated the effect of experimental preeclampsia on cerebral blood flow autoregulation in juvenile and adult offspring that were born from normal pregnant or experimentally preeclamptic rats. Read More

Endocrinol Diabetes Metab Case Rep 2022 Jun 1;2022. Epub 2022 Jun 1.

Oxford Centre for Endocrinology, Diabetes and Metabolism, Churchill Hospital, Oxford, UK.

Summary: Vaccine-induced thrombosis and thrombocytopenia (VITT) after vaccination against SARS-CoV-2 with the adenoviral vector-based vaccines ChAdOx1 and Ad26.COV2.S has been associated with adrenal pathology, such as bilateral adrenal vein thrombosis, adrenal cortex haemorrhage and adrenal insufficiency in 6% of patients. Read More

Front Endocrinol (Lausanne) 2022 1;13:877341. Epub 2022 Jun 1.

Department of Cardiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Background: Catecholamine excess arising from pheochromocytomas and paragangliomas (PPGLs) can cause a wide spectrum of cardiac manifestations. Although there are reviews of reported cases, these reviews lack detailed data, which makes it impossible to perform an accurate analysis. In this study, we conducted a comprehensive analysis of cardiovascular complications (CCs), including PPGL-related myocardial injury, cardiogenic shock, and arrhythmias requiring antiarrhythmic therapy, in a large cohort of patients with PPGL. Read More

Cureus 2022 May 14;14(5):e24989. Epub 2022 May 14.

Endocrinology and Metabolism, King Abdulaziz Medical City Riyadh, Riyadh, SAU.

It Is well known that abdominal pain during pregnancy has a broad differential diagnosis, which includes spontaneous adrenal hemorrhage (SAH), a rarely reported phenomenon in the literature, defined as an acute hemorrhage into the adrenal gland during pregnancy in the absence of a clear cause. Physicians should have a high suspicion for it due to the potentially life-threatening complications, as they present usually with a non-specific presentation. We present a case of symptomatic SAH in the third trimester of pregnancy that was successfully managed conservatively. Read More

Int J Surg Pathol 2022 Jun 16:10668969221102543. Epub 2022 Jun 16.

Division of Molecular Pathology and Translational Medicine, Tata Memorial Hospital (TMH), Homi Bhabha National Institute (HBNI) University, Parel, Mumbai, Maharashtra, India.

A solitary fibrous tumor (SFT) is a ubiquitous tumor that occurs across all ages. It is rarely reported in pediatric patients, especially as a congenital mass. A 1 year 7-month old male child presented with a slow-growing gluteal mass since birth along with a recent episode of bleeding. Read More

J Med Case Rep 2022 May 30;16(1):229. Epub 2022 May 30.

National Hospital of Sri Lanka, Colombo 10, Sri Lanka.

Background: Adrenocortical carcinoma is a rare malignancy (0.5-2 cases/million/year) with a poor prognosis. Hypercortisolism, virilization, and compressive features are among the common presentations of adrenocortical carcinoma. Read More

Horm Res Paediatr 2022 May 24. Epub 2022 May 24.

Introduction: There is emerging speculation that the inflammatory state associated with SARS-CoV-2 infection may trigger autoimmune conditions, but no causal link is established. There are reports of autoimmune thyroiditis, and adrenal insufficiency in adults post-COVID-19. We describe the first pediatric report of autoimmune adrenal insufficiency and hypothyroidism after COVID-19. Read More

Sci Prog 2022 Apr-Jun;105(2):368504221102786

Department of Rheumatology and Immunology, 74723The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Introduction: Eltrombopag, a kind of thrombopoietin (TPO) receptor agonist, plays the role on the megakaryocyte to activate the platelet production and rapidly increase the number of circulating platelets in patients with primary immune thrombocytopenia (ITP). Eltrombopag provides an opportunity for rapid tapering and/or cessation of corticosteroid therapy. However, it is not clear about the platelet response to Eltrombopag in ITP associated with Sjögren's Syndrome(SS). Read More

Eur Rev Med Pharmacol Sci 2022 May;26(9):3334-3341

Department of Emergency Medicine, Malatya Education and Research Hospital, Malatya, Turkey.

Objective: Nasal packing is used to stop bleeding in cases of epistaxis. Different topical drugs are preferred to these packs in the emergency department. In this study, we aimed to compare the efficacy of lidocaine, epinephrine and tranexamic acid (TXA) in stopping bleeding in patients with epistaxis. Read More

Am J Otolaryngol 2022 Jul-Aug;43(4):103476. Epub 2022 May 4.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Preoperative corticosteroids have been shown to improve surgical visibility and intraoperative blood loss for chronic rhinosinusitis with nasal polyposis (CRSwNP) patients undergoing endoscopic sinus surgery (ESS). However, there is no consensus on the optimal dosing regimen.

Methods: A randomized, controlled trial was conducted to compare low, medium, and high dose corticosteroids prior to ESS. Read More

BMJ Case Rep 2022 May 6;15(5). Epub 2022 May 6.

Obstetrics and Gynaecology, East and North Hertfordshire NHS Trust, Stevenage, Hertfordshire, UK.

Spontaneous adrenal haemorrhage (SAH) is a rare condition. The incidence of adrenal haemorrhage in pregnancy is currently not known; however, an association with pregnancy has been reported.An acute presentation with severe back or flank pain should raise suspicion of this condition. Read More

BMC Pediatr 2022 05 5;22(1):248. Epub 2022 May 5.

Department of Family Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Neonatal adrenal hemorrhage (NAH) is an almost infrequent phenomenon (0.2-0.55%). Read More

Endocrinol Diabetes Metab Case Rep 2022 May 1;2022. Epub 2022 May 1.

Department of Endocrinology & Diabetes, Alfred Hospital, Melbourne, Australia.

Summary: Adrenal gland haemorrhage is an uncommon, yet likely under-diagnosed complication of high-impact trauma, such as motor vehicle accidents (MVA). It usually occurs with multi-trauma and is associated with additional injuries to the ribs, liver, kidney, spleen and vertebrae. Trauma cases with resultant adrenal gland injury have higher mortality rates. Read More

Cureus 2022 Mar 23;14(3):e23413. Epub 2022 Mar 23.

Internal Medicine, Oklahoma City Veterans Affairs (VA) Medical Center, Oklahoma City, USA.

Bilateral adrenal hemorrhage is an extremely uncommon and life-threatening condition. It is caused by multiple etiologies, including antiphospholipid syndrome, disseminated histoplasmosis, trauma, severe stress, and granulomatous disease. The authors present a unique case of a 64-year-old alcoholic male, who was admitted after fall and right hip fracture. Read More

Clin Drug Investig 2022 Jun 27;42(Suppl 1):25-31. Epub 2022 Apr 27.

Servicio de Hepatología, Hemodinámica Hepática. Hospital Clínic, Barcelona, Spain.

Portal hypertension is a major complication of cirrhosis characterized by a pathological hepatic venous pressure gradient (HVPG) ≥ 5 mmHg. The structural changes observed in the liver leading to intrahepatic vascular resistance and, consequently, portal hypertension appear in the early stages of cirrhosis. Clinically significant portal hypertension (HVPG ≥ 10 mmHg) is associated with several clinical consequences, such as ascites, hyponatremia, gastroesophageal variceal bleeding, hepatorenal syndrome, cardiopulmonary complications, adrenal insufficiency, and hepatic encephalopathy. Read More

Viruses 2022 03 25;14(4). Epub 2022 Mar 25.

Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Virus infection of adrenal glands can disrupt secretion of mineralocorticoids, glucocorticoids, and sex hormones from the cortex and catecholamines from the medulla, leading to a constellation of symptoms such as fatigue, dizziness, weight loss, nausea, and muscle and joint pain. Specifically, varicella zoster virus (VZV) can produce bilateral adrenal hemorrhage and adrenal insufficiency during primary infection or following reactivation. However, the mechanisms by which VZV affects the adrenal glands are not well-characterized. Read More

Vaccines (Basel) 2022 Apr 12;10(4). Epub 2022 Apr 12.

Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

Vaccine-induced immune thrombotic thrombocytopenia (VITT) with venous thrombosis is a rare complication of SARS-CoV-2 vaccination with ChAdOx1 (AstraZeneca) and AD26.COV2.S (Johnson & Johnson, New Brunswick, NJ, USA) associated with high mortality. Read More

J Assoc Physicians India 2022 Apr;70(4):11-12

Vivekananda Polyclinic and Institute of Medical Sciences, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Apollomedics Hospital, IITR, Lucknow.

ICH is one of the most serious neurological emergency which can result in high mortality which may be related to catecholamine release. We aim to evaluate serum catecholamine levels in acute ICH and correlate their levels with clinical parameters of stress and outcome.

Material: Consecutive patients with CT proven ICH within 7 days of ictus were included and their clinical finding, SIRS Parameters, GCS, NIH score, laboratory parameters (ESR, CRP) were evaluated. Read More

Med Ultrason 2022 Mar 6. Epub 2022 Mar 6.

Ultrasound and Biopsy Diagnostics Lab at the Clinic of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk, Poland.

Aims: A focal lesion in the region of the adrenal gland in a newborn often requires further assessment. Ultrasound (US) is the initial imaging method of choice in young children as it does not use radiation or require sedation and it has excellent spatial resolution. In this case series, we present contrast-enhanced ultrasound (CEUS) as a problem-solving tool in the evaluation of neonatal adrenal lesions. Read More

Front Pharmacol 2022 1;13:852401. Epub 2022 Apr 1.

Department of Anesthesiology, ShengJing Hospital of China Medical University, Shenyang, China.

Post-stroke anxiety severely affects recovery in patients with intracerebral hemorrhage (ICH). Dexmedetomidine (Dex), a highly selective alpha 2 adrenal receptor (α2-AR) agonist, was recently found to exert an excellent protective effect against mental disorders including anxiety. The transient receptor potential vanilloid 4 (TRPV4) channel is involved in a series of diseases such as asthma, cancer, anxiety, and cardiac hypertrophy. Read More

Endocrine 2022 05 15;76(2):426-433. Epub 2022 Apr 15.

Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: Pheochromocytoma surgery carries a higher risk of hemorrhage. Our objective was to identify preoperative risk factors for hemorrhage during pheochromocytoma surgery.

Methods: Patients who underwent surgery and with postoperative pathological confirmation were enrolled. Read More

Am J Case Rep 2022 Apr 14;23:e936096. Epub 2022 Apr 14.

Department of Internal Medicine, Olive View - UCLA Medical Center, Sylmar, CA, USA.

BACKGROUND Waterhouse-Friderichsen syndrome, also known as acute adrenal insufficiency due to adrenal gland hemorrhage, is an uncommon and frequently fatal condition classically presenting with fever, shock, rash, and coagulopathy. Although most often associated with Meningococcemia, many other etiologies have been implicated, including reports of Staphylococcus aureus infection on autopsy examinations. This report details an adult intravenous drug user with adrenal hemorrhage associated with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Read More

Clin Exp Hepatol 2022 Mar 8;8(1):78-83. Epub 2022 Feb 8.

Internal Medicine Department, Hepatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Aim Of The Study: To estimate the prevalence of adrenal insufficiency (AI) in hemodynamically stable cirrhotic patients and to evaluate the potential association with patients' clinical characteristics, cirrhosis etiology and liver disease severity.

Material And Methods: The cross-sectional study included 132 stable liver cirrhosis patients. Severity of liver disease was graded using the Child-Pugh classification and Model for End-stage Liver Disease (MELD) score. Read More

J Burn Care Res 2022 May;43(3):525-529

Section of Plastic & Reconstructive Surgery, University of Chicago, Illinois, USA.

Tangential excision and grafting of burn wounds result in significant intraoperative blood loss, and infiltration of a dilute epinephrine solution (tumescence) is routinely performed to reduce such bleeding. Tumescent infiltration has been described using both a manual technique (syringe) and a pump device. The purpose of this study is to compare the efficiency of these two methods in terms of time and economy of motion. Read More

Cochrane Database Syst Rev 2022 04 4;4:CD003935. Epub 2022 Apr 4.

Liggins Institute, The University of Auckland, Auckland, New Zealand.

Background: Infants born preterm (before 37 weeks' gestation) are at risk of respiratory distress syndrome (RDS) and need for respiratory support due to lung immaturity. One course of prenatal corticosteroids, administered to women at risk of preterm birth, reduces the risk of respiratory morbidity and improves survival of their infants, but these benefits do not extend beyond seven days. Repeat doses of prenatal corticosteroids have been used for women at ongoing risk of preterm birth more than seven days after their first course of corticosteroids, with improvements in respiratory outcomes, but uncertainty remains about any long-term benefits and harms. Read More

J Clin Med 2022 Mar 13;11(6). Epub 2022 Mar 13.

IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.

Background: Giant pituitary adenomas are benign intracranial tumours with a diameter ≥4 cm. Even if hormonally non-functional, they may still cause local extension, leading to symptoms that include mostly gland dysfunction, mass effects, and, much less frequently, apoplexy due to haemorrhage or infarction. Neurological presentation of giant pituitary tumour apoplexy is even more rare and has not been systematically reviewed. Read More

Infect Dis Rep 2022 Mar 11;14(2):184-197. Epub 2022 Mar 11.

Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87106, USA.

Coronavirus disease 2019 (COVID-19) infection primarily involves the respiratory system but has many noteworthy extra pulmonary manifestations as well. We write this review to highlight the basis of some pathophysiological mechanisms of COVID-19 infection-induced endocrine dysfunction. Different scientific databases and institutional websites were searched to collect and consolidate the most up-to-date data relating to COVID-19 infection and endocrine systems. Read More