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    Bilateral Adrenal Hemorrhage in a Patient with Antiphospholipid Syndrome During Chronic Graft-versus-host Disease.
    Intern Med 2017 Dec 27. Epub 2017 Dec 27.
    Department of Endocrinology, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Japan.
    We present the case of a 56-year-old man with an upper respiratory infection followed by fatigue, hypotension, and hyponatremia. Bilateral adrenal hemorrhage was confirmed, based on T2-weighted magnetic resonance imaging. The patient had previously undergone allogeneic hematopoietic stem cell transplantation and had been diagnosed with antiphospholipid syndrome (APS) during the development of chronic graft-versus-host disease. Read More

    Isolated unilateral adrenal gland hemorrhage following motor vehicle collision: a case report and review of the literature.
    J Med Case Rep 2017 Dec 26;11(1):358. Epub 2017 Dec 26.
    Department of General Surgery, Henry Ford Wyandotte Hospital, 2333 Biddle Ave, Wyandotte, MI, 48192, USA.
    Background: Adrenal gland trauma is a rare condition that typically stems from blunt force trauma, and is associated with multiple organ injuries. Alternatively, isolated adrenal gland trauma is extremely rare, accounting for only 1.5 to 4% of all adrenal trauma cases. Read More

    Primary atrial fibromyxosarcoma with multiple-system metastases: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8930
    aDepartment of Radiation OncologybDepartment of PathologycDepartment of Cardiac Surgery, the First Hospital, China Medical University, Shenyang, China.
    Rationale: Fibromyxosarcoma is common in head and neck, vessel, omentum, and reproductive system, with low-grade malignant behavior. However, primary atrial fibromyxosarcoma with highly malignant behavior is extremely rare.

    Patient Concerns: A 34-year-old female presented with oppression in the chest, short breath, and onset of headache as initial symptoms. Read More

    Unilateral aggressive pheochromocytoma revealed by a massive intraperitoneal hemorrhage five years after an initial presentation suggesting an adrenal hematoma.
    Ann Endocrinol (Paris) 2017 Dec 11. Epub 2017 Dec 11.
    Département d'endocrinologie, diabétologie et médecine de la reproduction, hôpital de l'Archet 2, CHU de Nice, 151, route de Saint-Antoine de Ginestière, CS 23079, 06202 Nice cedex 3, France.

    Persistent Primary Aldosteronism Despite Iatrogenic Adrenal Hemorrhage After Adrenal Vein Sampling.
    J Clin Med Res 2018 Jan 1;10(1):66-71. Epub 2017 Dec 1.
    Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Japan.
    Before surgery for primary aldosteronism (PA), localization is evaluated with adrenal vein sampling (AVS). A 56-year-old Japanese woman had a right adrenal mass, hypokalemia, and a high aldosterone/renin ratio. Stress tests confirmed the diagnosis of PA. Read More

    Pseudomesotheliomatous carcinoma of the pleura: an autopsy case of metastasis from a G-CSF-producing anaplastic carcinoma of the pancreas.
    APMIS 2017 Dec 13. Epub 2017 Dec 13.
    Department of Molecular Pathology, Graduate school of Biomedical and Health Sciences Hiroshima University, Hiroshima, Japan.
    Pseudomesotheliomatous carcinoma is a malignant tumor that extends along the pleura mimicking malignant mesothelioma. An 81-year-old male patient presented to our hospital with epigastralgia, and abdominal computed tomography (CT) showed a 36-mm tumor in the pancreatic tail. The laboratory data revealed a high leukocyte count (>44 000/μL). Read More

    Evaluation and Management of Blunt Solid Organ Trauma.
    Tech Vasc Interv Radiol 2017 Dec 10;20(4):230-236. Epub 2017 Nov 10.
    Division of Interventional Radiology and Image-guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA.
    Trauma is a leading cause of death in patients under the age of 45 and generally associated with a high kinetic energy event such as a motor vehicle accident or fall from extreme elevations. Blunt trauma can affect every organ system and major vascular structure with potentially devastating effect. When we consider abdominal solid organ injury from blunt trauma, we usually think of the liver, spleen, and kidneys. Read More

    A rare case of Waterhouse- Friderichsen syndrome during primary Varicella zoster infection.
    Neth J Med 2017 Oct;75(8):351-353
    Department of Internal Medicine, Haaglanden Medical Centre, The Hague, the Netherlands.
    Primary Varicella zoster virus infection in adults is associated with a higher risk of complications when compared with the benign disease course of primary infection during childhood. We present a rare complication of adult primary Varicella zoster in the form of acute, irreversible adrenal insufficiency due to bilateral adrenal haemorrhage, which is also known as the WaterhouseFriderichsensyndrome. Read More

    Fetal adrenal gland enlargement - prenatal and postnatal management.
    • Authors:
    Neuro Endocrinol Lett 2017 Nov 4;38(Suppl1):31-34. Epub 2017 Nov 4.
    Background: The enlargement of suprarenal gland is related to preterm birth and the birth weight. The ultrasound measurement of fetal adrenal gland volume may identify women at risk for impending preterm birth. The aim of our study was to investigate the newborns in the region of western Slovakia followed up due to suprarenal gland enlargement. Read More

    A case report of primary adrenal angiosarcoma as depicted on magnetic resonance imaging.
    Medicine (Baltimore) 2017 Nov;96(45):e8551
    aDepartment of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China bDepartment of Pathology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China cDepartment of Urology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan China.
    Rationale: Angiosarcoma is an extremely rare malignant tumor of endothelial origin. The majority of studies reporting angiosarcoma have been concerned with the clinical and pathological aspects, with limited reporting of their imaging findings. To our knowledge, angiosarcoma of the adrenal gland is very rare. Read More

    Post-stroke depression: Mechanisms and pharmacological treatment.
    Pharmacol Ther 2017 Nov 9. Epub 2017 Nov 9.
    Laboratory of Pharmacology and Molecular Medicine of Central Nervous System, Department of Biology and Biotechnology, University of Pavia, Italy.
    Depression, the most frequent psychiatric disorder following ischaemic stroke, negatively affects survivals' functional outcome, response to rehabilitation and quality of life. Approximately, one-third of them are affected by post-stroke depression (PSD), making it a serious social and public health problem and anti-depressant preventive and curative therapies worth investigating. However, a two-way association between depression and stroke has been also established: stroke increases the risk of PSD, but depression is an independent risk factor for stroke. Read More

    Patients' comorbidities reduce the clinical value of emergency colonoscopy: results of a retrospective cohort study.
    Endosc Int Open 2017 Nov 8;5(11):E1119-E1127. Epub 2017 Nov 8.
    EC2M3: Department of Academic Research (EA7375) Université Paris Est Créteil (UPEC) - Val de Marne, France.
    Background And Study Aims:  Urgent endoscopy is often used to diagnose and sometimes treat acute upper gastrointestinal syndromes (hemorrhage, toxic ingestion, and occlusion). However, its suitability concerning the management of lower gastrointestinal conditions in emergency circumstances is controversial.

    Patients And Methods:  We studied the role of emergency colonoscopy in diagnosis and treatment of all consecutive patients presenting with acute lower gastrointestinal symptoms referred to our hospital on an emergency basis. Read More

    Successful Treatment of Iatrogenic External Iliac Artery Perforation With Covered Stent: Case Report and Review of the Literature.
    Cardiol Res 2017 Oct 27;8(5):246-253. Epub 2017 Oct 27.
    Division of Cardiology, University of South Alabama, Mobile, AL 36617, USA.
    Retroperitoneal hemorrhage from iliac artery injury is a potentially serious complication of vascular interventional procedures leading to hemorrhagic shock and death if not diagnosed early and treated promptly. We report a 70-year-old male admitted to our facility with non-ST-elevation myocardial infarction, whose heart catheterization revealed left anterior descending artery (LAD) with 80% proximal, 95% mid and 100% distal disease. The left circumflex and right coronary arteries were 100% occluded proximally and received collaterals from the LAD. Read More

    Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma.
    Case Rep Gastroenterol 2017 Sep-Dec;11(3):516-525. Epub 2017 Sep 13.
    Faculty of Medicine, Universidade de Caxias do Sul, Caxias do Sul, Brazil.
    Although extrahepatic metastases from hepatocellular carcinoma (HCC) are present in only 5-15% of cases, they are certainly factors associated with poor prognosis. The main sites include lung, lymph nodes, bones, and adrenal glands, in descending order. Metastasis in the central nervous system is extremely rare, and the incidences vary from 0. Read More

    Imaging of Nonmalignant Adrenal Lesions in Children.
    Radiographics 2017 Oct;37(6):1648-1664
    From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131-MIR, St Louis, MO 63110.
    The adrenal glands in children can be affected by a variety of benign lesions. The diagnosis of adrenal lesions can be challenging, but assessment of morphologic changes in correlation with the clinical presentation can lead to an accurate diagnosis. These lesions can be classified by their cause: congenital (eg, discoid adrenal gland, horseshoe adrenal gland, and epithelial cysts), vascular and/or traumatic (eg, adrenal hemorrhage), infectious (eg, granulomatous diseases), enzyme deficiency disorders (eg, congenital adrenal hyperplasia [CAH] and Wolman disease), benign neoplasms (eg, pheochromocytomas, ganglioneuromas, adrenal adenomas, and myelolipomas), and adrenal mass mimics (eg, extralobar sequestration and extramedullary hematopoiesis). Read More

    A Case of Hemorrhagic Adrenal Pseudocyst Mimicking Solid Tumor.
    Am J Case Rep 2017 Sep 27;18:1034-1038. Epub 2017 Sep 27.
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan.
    BACKGROUND Adrenal pseudocysts are often discovered incidentally on imaging, but the diagnosis and treatment can be challenging. A case of adrenal pseudocyst with hemorrhage is presented that mimicked a solid tumor on imaging, resulting in adrenalectomy. CASE REPORT A 78-year-old woman was found to have a right adrenal lesion on abdominal imaging. Read More

    Cerebral salt wasting syndrome in patients with minor head trauma - two case reports.
    Rom J Anaesth Intensive Care 2016 Oct;23(2):155-158
    Department of Anaesthesia and Intensive Care, Emergency County Hospital, Cluj-Napoca, Romania.
    We describe two polytrauma patients without severe head trauma who developed Cerebral Salt Wasting Syndrome (CSWS) during their stay in our ICU with natriuresis, hyponatremia and hypovolemia. Hyponatremia encountered in CSWS and the syndrome of inadequate antidiuretic hormone secretion (SIADH) is a common electrolyte finding in patients with severe head trauma, subarachnoid hemorrhage, malignancy and infections of the central nervous system. CSWS was an unexpected electrolyte finding in our patients with minor head trauma without neurological or neurosurgical problems. Read More

    Neonatal adrenal hemorrhage presenting as "Acute Scrotum"-looking beyond the obvious: a sonographic insight.
    J Ultrasound 2017 Sep 28;20(3):253-259. Epub 2017 Apr 28.
    Department of Radio-diagnosis, University College of Medical Sciences (University of Delhi) and GTB Hospital, Dilshad Garden, Delhi, 110095 India.
    Acute swelling and discoloration of scrotum in new born can have many localized causes like testicular torsion, inguinal hernia, scrotal or testicular edema, hydrocele, or even remote causes like adrenal hemorrhage. We report a neonate of adrenal hemorrhage presenting clinically as acute scrotum misguiding the clinician to rule out a local scrotal pathology. As the local clinical examination is not reliable in a newborn, it definitely requires an imaging evaluation to establish the diagnosis. Read More

    Spontaneous Adrenal Hematoma in a Pregnant Woman; a Case Report.
    Emerg (Tehran) 2017 24;5(1):e59. Epub 2017 Feb 24.
    Department of Anesthesiology, Imam Hosein Hospital, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
    Spontaneous adrenal hematoma is a very rare condition and its prevalence has been reported to be about 1% in previous studies. Although various causes have been proposed to explain its incidence in existing case reports, the etiology and pathology of this condition is still not known. The present study presents a case of spontaneous adrenal hematoma in a pregnant 31 year old womanwithout history of trauma or other probable risk factors of hemorrhage, presenting to the emergency department with chief complaint of pain in the right flank. Read More

    Assessment of neonatal adrenal size using high resolution 2D ultrasound and its correlation with birth demographics and clinical outcomes.
    J Matern Fetal Neonatal Med 2017 Sep 24:1-7. Epub 2017 Sep 24.
    d Department of Pediatrics, Division of Neonatology , Case Western Reserve University, MetroHealth Medical Center , Cleveland , OH , USA.
    Objective: Assessment of adrenal function in a sick neonate remains a challenge in spite of major advances in neonatal care. We used 2D ultrasound of adrenal glands to assess maturity of adrenal glands in extremely preterm infants and sick term and near term infants.

    Study Design: We collected demographics details of 99 mother-infants pairs (24-41 weeks) and obtained 2D ultrasound scans of adrenal glands in first week of life to measure adrenal volume, fetal zone size, and adrenal to kidney ratios. Read More

    Management of primary aldosteronism in patients with adrenal hemorrhage following adrenal vein sampling: A brief review with illustrative cases.
    J Clin Hypertens (Greenwich) 2017 Dec 9;19(12):1372-1376. Epub 2017 Sep 9.
    Section on Endocrinology & Genetics (SEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
    The authors describe the clinical investigation of two cases of primary aldosteronism with adrenal hemorrhage (AH) following adrenal vein sampling. A literature review was conducted regarding the medical management of primary aldosteronism in patients with AH following adrenal vein sampling. Guidelines on the management of primary aldosteronism with AH following adrenal vein sampling are lacking. Read More

    Organ- and cell-specific immune responses are associated with the outcomes of intracerebral hemorrhage.
    FASEB J 2018 Jan 6;32(1):220-229. Epub 2017 Sep 6.
    Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China;
    Severe brain injury significantly influences immune responses; however, the levels at which this influence occurs and which neurogenic pathways are involved are not well defined. Here, we used MRI to measure spleen volume and tissue diffusion changes in patients with intracerebral hemorrhage (ICH). We observed increased capillary exchange and spleen shrinkage by d 3 post-ICH, with recovery by d 14. Read More

    Management of Bleeding in Exclusive Endoscopic Ear Surgery: Pilot Clinical Experience.
    Otolaryngol Head Neck Surg 2017 Oct 5;157(4):700-706. Epub 2017 Sep 5.
    1 Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
    Objective Transcanal exclusive endoscopic ear surgery requires the management of the endoscope and the surgical instruments in the external auditory canal. Bleeding in this narrow space is one of the most challenging issues, especially for novice endoscopic ear surgeons. We aim to assess the severity and occurrence of bleeding and describe strategies to control the bleeding during endoscopic ear surgery. Read More

    The radiographically diagnosed adrenal myelolipoma: what do we really know?
    Endocrine 2017 Nov 2;58(2):289-294. Epub 2017 Sep 2.
    Departments of Surgery and Radiology, University of California, Davis Medical Center, Sacramento, CA, USA.
    Purpose: Adrenal myelolipomas are uncommon, benign tumors of the adrenal glands that are not routinely evaluated for autonomous hormone secretion or followed by repeat imaging, but may lead to retroperitoneal hemorrhage. Little is known about the natural history these tumors with the majority of previous publications being confined to case reports and small case series.

    Methods: We reviewed the computed tomography (CT) reports of 62,279 patients evaluated at a tertiary referral center between 2002 and 2015 for the presence of an adrenal myelolipoma >1 cm in size. Read More

    Inducing heat shock protein 70 expression provides a robust antithrombotic effect with minimal bleeding risk.
    Thromb Haemost 2017 Aug 27;117(9):1722-1729. Epub 2017 Jul 27.
    José Hermida, MD,PhD, University of Navarra, Center for Applied Medical Research (CIMA), Laboratory of Thrombosis and Haemostasis, Pío XII 55, Pamplona 31008, Spain, Tel.: +34948194700×3027, Fax: +34948194716, E-mail:
    Antithrombotic medications target coagulation factors. Their use is associated with an increased bleeding risk. Safer drugs are needed. Read More

    Acute hypopituitarism associated with periorbital swelling and cardiac dysfunction in a patient with pituitary tumor apoplexy: a case report.
    J Med Case Rep 2017 Aug 24;11(1):235. Epub 2017 Aug 24.
    Department of Respiratory Medicine, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.
    Background: Pituitary tumor apoplexy is a rare clinical syndrome caused by acute hemorrhage or infarction in a preexisting pituitary adenoma. It typically manifests as an acute episode of headache, visual disturbance, mental status changes, cranial nerve palsy, and endocrine pituitary dysfunction. However, not all patients present with classical symptoms, so it is pertinent to appreciate the clinical spectrum of pituitary tumor apoplexy presentation. Read More

    Nontraumatic adrenal hemorrhage: the adrenal stress.
    Radiol Case Rep 2017 Sep 15;12(3):483-487. Epub 2017 Apr 15.
    Radiology Department, San Carlo Hospital, Potito Petrone St, 85100 Potenza, Italy.
    Bilateral adrenal hemorrhage is a rare condition, which is burdened by potentially life-threatening consequences related to the development of acute adrenal insufficiency. Despite treatment with stress-dose glucocorticoids, a mortality rate of 15% has been reported, which varies according to the severity of underlying predisposing illness and could be much more higher if the adrenal insufficiency is not promptly recognized. An early diagnosis is crucial, though, because of nonspecific clinical and laboratory findings, adrenal hemorrhage is rarely suspected. Read More

    [Fortuitous discovery of an adrenal mass following spontaneous retroperitoneal hemorrhage].
    Rev Med Liege 2017 Jul;72(7-8):358-362
    Service de Chirurgie Digestive, CH Bois de l'Abbaye, Seraing, Belgique.
    We report a case of spontaneous retroperitoneal haemorrhage by bleeding of an adrenal adenoma. Retroperitoneal haemorrhages are rarely encountered in practice, but must be rapidly diagnosed due to the life threatening risk. The etiologies, clinical assessment, management and differential diagnosis of spontaneous retroperitoneal haemorrhages are discussed. Read More

    Predictors of remission in children with newly diagnosed immune thrombocytopenia: Data from the Intercontinental Cooperative ITP Study Group Registry II participants.
    Pediatr Blood Cancer 2018 Jan 9;65(1). Epub 2017 Aug 9.
    Division of Oncology/Hematology, University Children's Hospital, Basel, Switzerland.
    Background: Immune thrombocytopenia (ITP) during childhood spontaneously remits in up to 80% of children. Predictors of remission are not well understood.

    Procedure: We analyzed data from Intercontinental Cooperative ITP Study Group (ICIS) Registry II, a large prospective cohort of children with ITP, to investigate factors that might predict remission. Read More

    Successful management of recurrent bleeding with tocilizumab in an acquired hemophilia A patient with rheumatoid arthritis.
    Rinsho Ketsueki 2017 ;58(7):738-742
    Department of Hematology, National Hospital Organization Kure Medical Center/Chugoku Cancer Center.
    A 61-year-old woman with rheumatoid arthritis was diagnosed as having acquired hemophilia A with extensive subcutaneous bleeding. The patient was treated with a corticosteroid, and her symptoms improved temporarily. However, these recurred during the tapering of her corticosteroid dose, and neither the re-increase in the dose nor the addition of cyclophosphamide could control her bleeding tendency. Read More

    Brain-Heart Interaction: Cardiac Complications After Stroke.
    Circ Res 2017 Aug;121(4):451-468
    From the Gerontology and Neurological Institute, Tianjin Medical University General Hospital, China (Z.C., T.Y., J.C.); Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., D.S., M.C., J.C.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
    Neurocardiology is an emerging specialty that addresses the interaction between the brain and the heart, that is, the effects of cardiac injury on the brain and the effects of brain injury on the heart. This review article focuses on cardiac dysfunction in the setting of stroke such as ischemic stroke, brain hemorrhage, and subarachnoid hemorrhage. The majority of post-stroke deaths are attributed to neurological damage, and cardiovascular complications are the second leading cause of post-stroke mortality. Read More

    Non-Surgical Management of Bilateral Adrenal Abscess in Neonates: Report of Two Cases.
    J Neonatal Surg 2017 Apr-Jun;6(2):31. Epub 2017 Apr 15.
    Department of Pediatric Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
    Adrenal hemorrhage is not uncommon in neonates but the development of an adrenal abscess is extremely rare. Bilateral adrenal abscess is even rarer with less than ten cases documented in the medical literature. It may have a fatal outcome if inadequately treated. Read More

    Upper Gastrointestinal Bleed as a Manifestation of Poorly Differentiated Metastatic Squamous Cell Carcinoma of the Lung.
    J Clin Diagn Res 2017 Jun 1;11(6):OD13-OD14. Epub 2017 Jun 1.
    Attending Physician, Department of Gastroenterology and Hepatology, University of Connecticut, Farmington, Connecticut, USA.
    Gastrointestinal (GI) metastasis from primary lung cancer is a rare clinical finding. Lung cancer most often metastasizes to the brain, bone, liver, and adrenal glands; with gastrointestinal involvement being very rare. We report a case of a 39-year-old female with a diagnosis of poorly differentiated Squamous Cell Carcinoma (SCC) of the lung presenting with dizziness and melena. Read More

    Adrenal Imaging.
    Endocrinol Metab Clin North Am 2017 Sep 12;46(3):741-759. Epub 2017 Jun 12.
    Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, B1G503, Ann Arbor, MI 48109-5030, USA. Electronic address:
    Cross-sectional imaging can make a specific diagnosis in lesions, such as myelolipomas, cysts, and hemorrhage, and is often sufficient to distinguish benign from malignant adrenal processes. CT and MRI are useful studies to identify pheochromocytomas and cortisol-secreting or androgen-secreting tumors. In patients with primary aldosteronism, adrenal venous sampling remains the most accurate localizing study and should be performed in all patients older than 35. Read More

    In Individuals Following Aneurysmal Subarachnoid Haemorrhage, Hair Cortisol Concentrations Are Higher and More Strongly Associated with Psychological Functioning and Sleep Complaints than in Healthy Controls.
    Neuropsychobiology 2017 28;75(1):12-20. Epub 2017 Jul 28.
    Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
    Background: Following an aneurysmal subarachnoid haemorrhage (aSAH), many patients report persistent deficits in psychological functioning, characterised by high levels of stress and symptoms of depression, low life satisfaction, along with poor sleep. Such deficits have been associated with altered saliva and serum cortisol levels due to a dysregulation of hypothalamic-pituitary-adrenal axis activity (HPA-AA). However, hair cortisol concentrations (HCCs) have not been assessed in this population, although this method allows a long-term insight into cortisol values. Read More

    Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).
    Platelets 2017 Jul 20:1-3. Epub 2017 Jul 20.
    b McAllister Heart Institute , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina , USA.
    Congenital platelet function disorders are often the result of defects in critical signal transduction pathways required for platelet adhesion and clot formation. Mutations affecting RASGRP2, the gene encoding the Rap GTPase activator, CalDAG-GEFI, give rise to a novel, and rare, group of platelet signal transduction abnormalities. We here report platelet function studies for two brothers (P1 and P2) expressing a novel variant of RASGRP2, CalDAG-GEFI(p. Read More

    Duodenal hematoma caused by endoscopic hemostatic procedures (sclerotherapy).
    Rev Esp Enferm Dig 2017 Sep;109(9):666
    Servicio de Aparato Digestivo A, Complejo Hospitalario de Navarra, España.
    Endoscopic hemostatic procedures such as local injection of epinephrine are commonly used for the treatment of bleeding ulcers. Although the risks are usually considered to be minimal, there are reports describing that duodenal intramural hematomas may develop as a complication after endoscopy especially in patients susceptible to hemorrhage such as those with anticoagulants therapy or blood dyscrasia. Read More

    Metachronous bilateral adrenal hemorrhage in primary antiphospholipid syndrome.
    Med Clin (Barc) 2017 Oct 26;149(7):318. Epub 2017 Jun 26.
    Servicio de Endocrinología y Nutrición, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, España; Universidad de Barcelona, Barcelona, España.

    BIlateral juxtapapillary retinal capillary haemangioma: Usefulness of aflibercept in the management of its complications.
    Arch Soc Esp Oftalmol 2017 Oct 23;92(10):477-480. Epub 2017 Jun 23.
    Servicio de Oftalmología, Hospital Virgen del Puerto, Plasencia (Cáceres), España.
    Case Report: A 45 year-old man with a history of adrenal phaeochromocytoma presented with a subretinal juxtapapillary haemorrhage on his left eye and a small asymptomatic vascular tumour in the contralateral eye. With the mentioned findings, the patient was diagnosed with bilateral retinal capillary haemangioma in the context of a von Hippel Lindau disease. Intravitreal aflibercept was prescribed, with a good outcome of the disease. Read More

    Intra-abdominal bleeding with hemorrhagic shock: a case of adrenal myelolipoma and review of literature.
    BMC Surg 2017 06 26;17(1):74. Epub 2017 Jun 26.
    Department of General Surgery, Kaohsiung Armed Forces General Hospital, No.2, Zhongzheng 1st Rd., Lingya Dist, Kaohsiung City, 802, Taiwan.
    Background: Adrenal myelolipoma is an uncommon, benign, and hormonally non-functioning tumor that is composed of mature adipose tissue and normal hematopoietic tissue. Most cases to date are asymptomatic or have epigastric pain. Acute hemorrhage is the most dramatic manifestation of adrenal myelolipoma; though, it is a rare entity. Read More

    Data-mining for detecting signals of adverse drug reactions of fluoxetine using the Korea Adverse Event Reporting System (KAERS) database.
    Psychiatry Res 2017 Oct 13;256:237-242. Epub 2017 Jun 13.
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. Electronic address:
    Selective serotonin reuptake inhibitors (SSRIs) have become one of the most broadly used medications in psychiatry. Fluoxetine is the first representative antidepressant SSRI drug approved by the Food and Drug Administration (FDA) in 1987. Safety information on fluoxetine use alone was less reported than its combined use with other drugs. Read More

    Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding.
    Blood 2017 08 21;130(8):1026-1030. Epub 2017 Jun 21.
    School of Clinical Sciences, University of Bristol, Bristol, United Kingdom.
    Heritable platelet function disorders (PFDs) are genetically heterogeneous and poorly characterized. Pathogenic variants in RASGRP2, which encodes calcium and diacylglycerol-regulated guanine exchange factor I (CalDAG-GEFI), have been reported previously in 3 pedigrees with bleeding and reduced platelet aggregation responses. To better define the phenotype associated with pathogenic RASGRP2 variants, we compared high-throughput sequencing and phenotype data from 2042 cases in pedigrees with unexplained bleeding or platelet disorders to data from 5422 controls. Read More

    High resolution magnetic resonance imaging for exposing facial nerve zonal vulnerability to microbleeds: A rare cause of facial palsy.
    Neuroradiol J 2017 Aug 20;30(4):385-388. Epub 2017 Jun 20.
    1 Department of Medical Imaging, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
    Background We report a case of hypertensive microbleeds strategically located at the attached segment (AS) and root entry zone (REZ) at the left facial nerve causing facial paralysis. Case Report A 60-year-old woman presented with sudden onset left facial paralysis. Medical history was significant for poorly controlled hypertension secondary to bilateral adrenal hyperplasia (primary hyperaldosteronism). Read More

    Differences between Takotsubo cardiomyopathy and reverse Takotsubo cardiomyopathy associated with subarachnoid hemorrhage.
    Int J Cardiol Heart Vasc 2016 Jun 11;11:99-103. Epub 2016 May 11.
    Department of Neurosurgery, Fujita Health University Hospital, Toyoake, Japan.
    Background: Both Takotsubo cardiomyopathy (TTC) and reverse TTC (r-TTC) are characterized by reversible regional wall motion abnormalities of the heart unrelated to coronary artery pathology. It remains unclear whether and/or how r-TTC differs from TTC. Subarachnoid hemorrhage (SAH) is occasionally causative of TTC/r-TTC, and this study was conducted to detect possible differences between TTC and r-TTC associated with SAH. Read More

    A case of acute Sheehan's syndrome and literature review: a rare but life-threatening complication of postpartum hemorrhage.
    BMC Pregnancy Childbirth 2017 Jun 14;17(1):188. Epub 2017 Jun 14.
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
    Background: Sheehan's syndrome occurs because of severe postpartum hemorrhage causing ischemic pituitary necrosis. Sheehan's syndrome is a well-known condition that is generally diagnosed several years postpartum. However, acute Sheehan's syndrome is rare, and clinicians have little exposure to it. Read More

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