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    1 OF 155

    Adrenal obliteration by balloon-occluded retrograde venous ethanol injection in a swine model.
    Minim Invasive Ther Allied Technol 2017 May 19:1-9. Epub 2017 May 19.
    a Department of Radiology , Shiga University of Medical Science , Shiga , Japan.
    Purpose: To evaluate the effects of adrenal obliteration by balloon-occluded retrograde venous ethanol injection.

    Material And Methods: We inserted a micro-balloon catheter into the left adrenal vein of six pigs and retrogradely injected absolute ethanol (0.06 ml/kg) under balloon occlusion. Read More

    Development of intracerebral hemorrhage in the short-term clinical course of a patient with microscopic polyangiitis without neurological symptoms at diagnosis: an autopsy case.
    CEN Case Rep 2016 Nov 5;5(2):173-178. Epub 2016 Apr 5.
    Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama City, 700-8558, Japan.
    A 77-year-old man with high-grade fever, progressive renal dysfunction, high serum level of C-reactive protein and positive serum myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) was diagnosed with microscopic polyangiitis with rapidly progressive glomerulonephritis, and remission induction treatment with glucocorticoids and intravenous cyclophosphamide was initiated. Although his general condition improved in a short time, intracerebral hemorrhage occurred 12 days after the initiation of treatment and emergent hematoma evacuation was performed. However, he passed away on day 14. Read More

    Two Cases of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with High Serum Procalcitonin Levels, Including the First Case Complicated with Adrenal Hemorrhaging.
    Intern Med 2017 15;56(10):1247-1252. Epub 2017 May 15.
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
    Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis/Renal failure, and Organomegaly (TAFRO) syndrome is a recently described systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly. It has an acute or subacute onset of unknown etiology, although some pathological features resemble those of multicentric Castleman disease. We here report two cases of TAFRO syndrome. Read More

    TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-label, Non-randomized Phase 1 Study.
    Cancer Res Treat 2017 May 10. Epub 2017 May 10.
    Department of Experimental Therapeutics, National Cancer Center Hospital East, Chiba, Japan.
    Purpose: This phase 1 dose-escalation portion of the study evaluated the safety, pharmacokinetics (PK), and antitumor activity of TAK-264 in Asian patients with advanced gastrointestinal (GI) carcinoma or metastatic or recurrent gastric or gastroesophageal junction adenocarcinoma expressing guanylyl cyclase C (GCC).

    Materials And Methods: Adult patients with advanced GI malignancies expressing GCC (H-score ≥ 10) received TAK-264 on day 1 of 3-week cycles as 30-minute intravenous infusions for up to 1 year or until disease progression or unacceptable toxicity. The primary objectives were to evaluate the safety profile including dose-limiting toxicities (DLTs) during cycle 1, determine the maximum tolerated dose (MTD), and characterize the PK profile of TAK-264 (NCT02391038). Read More

    Epinephrine-induced Takotsubo Cardiomyopathy During Laparoscopic Myomectomy: Case Report and Review of the Literature.
    J Minim Invasive Gynecol 2017 May 6. Epub 2017 May 6.
    Department of Obstetrics and Gynecology.
    Laparoscopic myomectomy, a minimally invasive procedure performed for the management of uterine leiomyomas involves a challenging aspect: excessive local bleeding. Hemorrhage control during laparoscopic myomectomy could be reached through the use of a wide range of vasoconstrictors including epinephrine. Epinephrine is frequently used for the control of local bleeding during surgery; however, it has been associated with several complications. Read More

    Clinical Characteristics and Current Interventions in Shock Patients in Chinese Emergency Departments: A Multicenter Prospective Cohort Study.
    Chin Med J (Engl) 2017 May;130(10):1146-1154
    Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China.
    Background: Shock is a life-threatening condition in emergency departments (EDs) and is associated with a high mortality; however, its clinical characteristics and current interventions in China are seldom reported. This study investigated the clinical characteristics and current interventions of shock patients in Chinese EDs.

    Methods: This multicenter prospective cohort study was conducted in the EDs of 33 academic hospitals in 16 Chinese provinces. Read More

    Spontaneous Adrenal Hemorrhage in Pregnancy: A Case Series.
    Case Rep Obstet Gynecol 2017 22;2017:3167273. Epub 2017 Mar 22.
    Department of Obstetrics and Gynecology, Crozer Chester Medical Center, One Medical Center Boulevard, Upland, PA 19013, USA.
    Background. Abdominal pain during pregnancy has a broad differential diagnosis which includes spontaneous adrenal hemorrhage (SAH). There is scant literature available on optimal mode of delivery in stable patients. Read More

    Cardiopulmonary resuscitation of out-of-hospital traumatic cardiac arrest in Qatar: A nationwide population-based study.
    Int J Cardiol 2017 Mar 30. Epub 2017 Mar 30.
    Department of Medicine Solna, 171 00, Karolinska Institutet, Sweden. Electronic address:
    Background: Traumatic cardiac arrest studies have reported improved survival rates recently, ranging from 1.7-7.5%. Read More

    Preoperative adrenal artery embolization followed by surgical excision of giant hypervascular adrenal masses: report of three cases.
    Acta Chir Belg 2017 Apr 7:1-7. Epub 2017 Apr 7.
    a Istanbul Faculty of Medicine, General Surgery Department , Istanbul University , Istanbul , Turkey.
    Background: Transcatheter arterial embolization (TAE) is an effective minimally invasive adjunct to surgery for the management and/or palliation of adrenal tumors.

    Methods: In this case study, we reported three patients who underwent preoperative TAE before adrenalectomy for large hypervascular adrenal tumors. All patients underwent preoperative embolization 24 h before the operation and were then followed up at the intensive care unit surgery. Read More

    Postural Syncope and Constipation: An Unusual Presentation of a Duodenal Dieulafoy's Lesion.
    Case Rep Gastrointest Med 2017 7;2017:6983434. Epub 2017 Mar 7.
    Department of Internal Medicine, Seton Hall University School of Health and Medical Sciences, Saint Francis Medical Center, Trenton, NJ, USA.
    Dieulafoy lesions are a rare etiology of gastrointestinal bleeding from a large caliber-persistent tortuous submucosal artery. They account for 1-2% of all causes of acute gastrointestinal hemorrhage with 80%-95% of these lesions located in the stomach along the lesser curvature. One-third of these lesions present at an extragastric location, with the proximal duodenum accounting for 15% of them. Read More

    Exposure to any antenatal corticosteroids and outcomes in preterm infants by gestational age: prospective cohort study.
    BMJ 2017 Mar 28;356:j1039. Epub 2017 Mar 28.
    Division of Neonatology, University of Alabama at Birmingham, AL 35233, USA.
    Objective To determine whether exposure to any antenatal corticosteroids is associated with a lower rate of death at each gestational age at which administration is currently recommended.Design Prospective cohort study.Settings 300 participating neonatal intensive care units of the Pediatrix Medical Group in the United States. Read More

    Adrenal Histologic Stress-related Changes in Third Trimester Stillbirth.
    Pediatr Dev Pathol 2017 Mar-Apr;20(2):112-119. Epub 2017 Jan 25.
    1 Department of Pathology, Hutzel Women's Hospital and Harper University Hospital, Wayne State University School of Medicine, Detroit, Michigan, USA.
    Adrenal histologic changes, including compact cell change (CCC), cystic change (CYC), and adrenal hemorrhage (AH), and their clinical correlations have only infrequently been investigated in stillbirth. We evaluated 75 third trimester singleton stillborns with complete autopsies (30 term and 45 preterm). A total of 58 had unexplained stillbirth and 17 had clinical placental abruption. Read More

    Chronic Subdural Hematoma ICU Management.
    Neurosurg Clin N Am 2017 Apr;28(2):239-246
    Departments of Neurosurgery and Neurology, Division of Neurocritical Care McGovern Medical School, 6431 Fannin Street, Medical School Building 7.152, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:
    Patients with cSDH presenting with new or worsening neurological deficits, especially if they are debilitating and adversely affecting quality of life require urgent medical and surgical attention. Neurological and neurosurgical critical care team need to stabilize the patient by reversing any underlying coagulopathy states in order to prevent further hematoma expansion.In the event of brain herniation and presumed ICP elevation and CPP compromise, step-wise ICP management should be instituted promptly. Read More

    Chronic Subdural Medical Management.
    Neurosurg Clin N Am 2017 Apr 1;28(2):211-217. Epub 2017 Feb 1.
    Department of Neurology, Columbia University Medical Center, 177 Fort Washington Avenue, Milstein Building 8GS-300, New York, NY 10032, USA.
    Chronic subdural hematomas (cSDHs) that are asymptomatic or have minimal symptoms have become more prevalent, with an increased rate of detection with neuroimaging in the setting of an aging population and increasing use of anticoagulants. These cSDHs have been known to spontaneously resolve, and subsequent efforts have been made to study the role of nonoperative initial medical management strategies in these patients. Current and potential strategies for the medical management of cSDH are discussed. Read More

    Characteristics and outcomes of very low birth weight infants receiving epinephrine during delivery room resuscitation.
    Resuscitation 2017 Jun 18;115:1-4. Epub 2017 Mar 18.
    Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Memphis, TN, USA; OB/GYN, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:
    Background: Delivery room resuscitation of very low birth weight infants can involve use of endotracheal or intravenous epinephrine. Data of the past 19 years were reviewed to identify the usage of epinephrine in delivery room and identify characteristics of these babies.

    Methods: Neonates with ≤1500g birthweight from January 1996 to August 2014 were reviewed. Read More

    Conservative Treatment for Idiopathic Adrenal Hemorrhage Tracked by a Long-term Series of CT Images.
    Intern Med 2017 17;56(6):673-676. Epub 2017 Mar 17.
    Department of Endocrinology and Diabetes, National Hospital Organization, Nagoya Medical Center, Japan.
    A 55-year-old man was transported to our hospital after a sudden onset of left lower abdominal pain while driving. Computed tomography (CT) of the abdominal region revealed an extensive iso-intense signal region that had a maximum area of 14×15 cm, which we treated conservatively. A series of follow-up CT images showed the gradual decrease of the left peritoneal mass, while continuity with the left adrenal gland became apparent. Read More

    Bilateral adrenal hemorrhage in the background of Escherichia coli sepsis: a case report.
    J Med Case Rep 2017 Mar 17;11(1):72. Epub 2017 Mar 17.
    St Helier Hospital, Wrythe Lane, Carshalton, SM5 1AA, UK.
    Background: Sepsis is a syndrome of life-threatening organ dysfunction caused by a dysregulated host response to infection. It can have devastating consequences, including bilateral adrenal hemorrhage, particularly in patients at high thrombotic risk, such as those with antiphospholipid syndrome and those on long-term anticoagulation.

    Case Presentation: A 49-year-old white woman re-presented to hospital with a history suggestive of sepsis. Read More

    Long-term safety of once-daily, dual-release hydrocortisone in patients with adrenal insufficiency: a phase 3b, open-label, extension study.
    Eur J Endocrinol 2017 Jun 14;176(6):715-725. Epub 2017 Mar 14.
    Department of EndocrinologySahlgrenska University Hospital and Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Objective: To investigate the long-term safety and tolerability of a once-daily, dual-release hydrocortisone (DR-HC) tablet as oral glucocorticoid replacement therapy in patients with primary adrenal insufficiency (AI).

    Design: Prospective, open-label, multicenter, 5-year extension study of DR-HC conducted at five university clinics in Sweden.

    Methods: Seventy-one adult patients diagnosed with primary AI who were receiving stable glucocorticoid replacement therapy were recruited. Read More

    Estrogen receptors ERα and ERβ participation in hypothalamus-pituitary-adrenal axis activation by hemorrhagic stress.
    Neuroscience 2017 May 6;349:239-252. Epub 2017 Mar 6.
    Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto - SP, Brazil. Electronic address:
    The sympato-adrenal-system and hypothalamus-pituitary-adrenal (HPA) axis are anatomically and functionally connected with participation of several brain areas that express estrogen receptors (ERα and ERβ). We assessed the neuronal activity of these areas for FOS expression and the action of PPT (ERα agonist) or DPN (ERβ agonist) in HPA axis activity during hemorrhagic stress. Ovariectomized Wistar rats treated with vehicle (DMSO) or ER agonists were catheterized for blood collection. Read More

    Anterior Transabdominal Laparoscopic Adrenalectomy, without Ligatures, for a Symptomatic Right Adrenal Myelolipoma with Intratumoral Hemorrhage.
    Chirurgia (Bucur) 2017 Jan-Feb;112(1):58-62
    Myelolipomas represent 3-7% fromthe primary tumors of the adrenal gland. Most often they are incidental findings. In most cases are asymptomatic, rarely they present symptoms (pain, abdominal discomfort, hematuria or signs of internal hemorrhage). Read More

    Cystic adrenal lesions: focus on pediatric population (a review).
    Clujul Med 2017 15;90(1):5-12. Epub 2017 Jan 15.
    Endocrinology Department, Iuliu Hatieganu University of Medicine and Pharmacy & Clinical County Hospital, Cluj-Napoca, Romania.
    Background And Aim: The cysts may potentially affect any organ; adrenals cysts are rare. This is a review of the literature regarding adrenal cysts, focusing on children and young adults.

    General Data: Three major types have been described: pure cysts (endothelial, epithelial, and hemorrhagic or pseudocyst), parasitic (as hydatid) cysts and cystic part of a tumour (most frequent are neuroblastoma, ganglioneuroma, pheocromocytoma, and teratoma). Read More

    Tension pneumomediastnum: A rare cause of acute intraoperative circulatory collapse in the setting of unremarkable TEE findings.
    J Clin Anesth 2017 Feb 12;37:136-138. Epub 2017 Jan 12.
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:
    Design: Case report.

    Setting: Operating room.

    Patient: 25YF, ASA IV E who underwent an emergent decompressive craniectomy for refractory intracranial hypertension secondary to acute intracranial hemorhage. Read More

    Delayed hemorrhage effect of local anesthesia with epinephrine in the loop electrosurgical excisional procedure.
    Obstet Gynecol Sci 2017 Jan 19;60(1):87-91. Epub 2017 Jan 19.
    Institute of Women's Life Medical Science, Women's Cancer Clinic, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
    Objective: The aim of this study was to investigate factors preventing delayed hemorrhage after the loop electrosurgical excisional procedure (LEEP).

    Methods: Medical records of patients who underwent LEEP at one university affiliated hospital from October 2013 to January 2015 were reviewed. Patients with or without delayed hemorrhage were classified. Read More

    Imaging of unilateral adrenal hemorrhages in patients after blunt abdominal trauma: Report of two cases.
    Chin J Traumatol 2017 Feb 19;20(1):52-55. Epub 2017 Jan 19.
    Department of Radiology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
    Adrenal hemorrhage following blunt abdominal trauma is extremely rare. Most of the lesions are unilateral and right sided. Although often asymptomatic, life-threatening adrenal insufficiency may develop in the bilateral adrenal gland hemorrhage. Read More

    Spontaneous Unilateral Adrenal Hemorrhage in Pregnancy.
    Cureus 2017 Jan 13;9(1):e977. Epub 2017 Jan 13.
    Endocrinology, University of Kansas School of Medicine-Wichita.
    Spontaneous adrenal hemorrhage (SAH) is a serious medical condition associated with variable clinical presentation depending on the extent of the hemorrhage. Pregnancy-induced adrenal hemorrhage is poorly understood. A low cortisol level in the peripartum period with radiological findings is sufficient to establish the diagnosis. Read More

    Stroke disclosing primary aldosteronism: Report on three cases and review of the literature.
    Ann Endocrinol (Paris) 2017 Feb 4;78(1):9-13. Epub 2017 Feb 4.
    Department of Neurology, Military Hospital, 1008, Montfleury, 1089 Tunis, Tunisia.
    Objectives: There is a growing evidence of increased risk of cerebrovascular events in primary aldosteronism (PA). Nevertheless, acute neurologic ailment as presenting feature of PA is uncommon. Our aim is to highlight the diagnosis challenges in stroke unmasking PA and to discuss the underlying physiopathology and management dilemmas. Read More

    Practical Approach to Adrenal Imaging.
    Radiol Clin North Am 2017 Mar 12;55(2):279-301. Epub 2016 Dec 12.
    Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1473, Houston, TX 77030, USA.
    Various pathologies can affect the adrenal gland. Noninvasive cross-sectional imaging is used for evaluating adrenal masses. Accurate diagnosis of adrenal lesions is critical, especially in cancer patients; the presence of adrenal metastasis changes prognosis and treatment. Read More

    Pheochromocytoma Multisystem Crisis Behaving Like Interstitial Pneumonia: An Autopsy Case.
    Intern Med 2017 15;56(2):149-152. Epub 2017 Jan 15.
    Department of Cardiology, Fuchu Hospital, Japan.
    Pheochromocytoma multisystem crisis is a rare and life-threatening disease that is associated with numerous symptoms and which is also difficult to diagnose. We herein report an autopsy case of a 61-year-old man who died due to pheochromocytoma multisystem crisis. The patient complained of vomiting and breathlessness. Read More

    Dieulafoy's lesion of the oesophagus: a case series and literature review.
    BMJ Case Rep 2017 Jan 6;2017. Epub 2017 Jan 6.
    SUNY Downstate Medical Center, New York, New York, USA.
    Dieulafoy's lesion is a vascular abnormality consisting of a tortuous, dilated aberrant submucosal vessel that erodes the overlying mucosal layer without ulceration. The oesophagus is a very rare location for the lesion. Herein, we report a case series of 3 patients who presented with upper gastrointestinal bleeding. Read More

    [IgA vasculitis (Henoch-Schönlein purpura)].
    Wiad Lek 2016;69(5):711-713
    Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska.
    IgA vasculitis (Schönlein-Henoch purpura) is a systemic inflammation of the small vessels associated with the deposition of IgA antibodies in the vascular wall. Typical clinical symptoms are: skin lesions (purpura), joint pain, abdominal discomfort and renal disorder (most common haematuria/proteinuria). The disease affects usually the pediatric population; in those patients its course is benign and usually not associated with permanent complications. Read More

    A double-blind randomized prospective study comparing prilocaine versus ropivacaine in upper blepharoplasty.
    J Plast Reconstr Aesthet Surg 2017 Mar 19;70(3):375-379. Epub 2016 Nov 19.
    Department of Plastic and Reconstructive Surgery, Hospital of the Barmherzigen Brüder, Teaching hospital of the Paracelsus Medical University Salzburg, Kajetanerplatz 1, 5020 Salzburg, Austria.
    Background: Upper blepharoplasties are a common procedure in plastic surgery. This procedure can be performed effectively under local anesthesia with or without sedation. The ideal local anesthetic should cause less intraoperative bleeding and less postoperative edema. Read More

    Streptococcus Pneumoniae Detection Long Time After Death in a Fatal Case of Waterhouse-Friderichsen Syndrome.
    Am J Forensic Med Pathol 2017 Mar;38(1):18-20
    From the *Forensic Medicine Unit, Section of Public Health and Human Sciences, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, and †Microbiology Section, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
    We report a fatal case of Waterhouse-Friderichsen syndrome in a 64-year-old man. The diagnosis, suspected during the autopsy (performed 63 hours after death), was confirmed through the successful detection of Streptococcus pneumoniae DNA and antigens in samples (blood and liver) collected during the autopsy. These results conformed with blood cultures performed antemortem, which became available only the day after the autopsy. Read More

    Sheehan syndrome.
    Nat Rev Dis Primers 2016 12 22;2:16092. Epub 2016 Dec 22.
    Department of Endocrinology, Erciyes University Medical School, 38039, Kayseri, Turkey.
    Sheehan syndrome or postpartum hypopituitarism is a condition characterized by hypopituitarism due to necrosis of the pituitary gland. The initial insult is caused by massive postpartum haemorrhage (PPH), leading to impaired blood supply to the pituitary gland, which has become enlarged during pregnancy. Small sella turcica size, vasospasms (caused by PPH) and/or thrombosis (associated with pregnancy or coagulation disorders) are predisposing factors; autoimmunity might be involved in the progressive worsening of pituitary functions. Read More

    Intraoperative Gastric Intramural Hematoma: A Rare Complication of Percutaneous Endoscopic Gastrostomy.
    Am J Case Rep 2016 Dec 19;17:963-966. Epub 2016 Dec 19.
    Department of Gastroenterology, Aventura Hospital and Medical Center, Aventura, FL, USA.
    BACKGROUND Intramural hematomas primarily present in the esophagus or duodenum. We report a case of intramural hematoma in the gastric wall (GIH) secondary to percutaneous endoscopic gastrostomy (PEG) tube placement in a setting of platelet dysfunction. CASE REPORT This case study reviews the hospitalization of a 73-year-old male with a history of chronic kidney disease who was admitted for coronary artery bypass graft surgery and mitral valve repair. Read More

    Prevention and management of glucocorticoid-induced side effects: A comprehensive review: Gastrointestinal and endocrinologic side effects.
    J Am Acad Dermatol 2017 Jan;76(1):11-16
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Part 2 of this 4-part continuing medical education series continues with a discussion of the prevention and management of gastrointestinal side effects associated with corticosteroid use, including peptic ulcer disease, gastrointestinal bleeding, and pancreatitis, followed by a review of corticosteroid-related endocrinologic side effects, such as diabetes, adrenal suppression, and Cushing syndrome. Read More

    [Rupture of Adrenal Artery Aneurysm : A Case Report].
    Hinyokika Kiyo 2016 Oct;62(10):515-519
    The Department of Radiology, Himeji Medical Center.
    A 45-year-old man with severe left flank pain was brought by ambulance to our hospital early in the morning. On arrival, his circulation dynamics were stable. His urinalysis results were normal, and ultrasonography showed no hydronephrosis. Read More

    Autoimmune Cytopenias: Diagnosis & Management.
    R I Med J (2013) 2016 Dec 1;99(12):36-40. Epub 2016 Dec 1.
    Department of Transfusion Medicine, Rhode Island Hospital and The Miriam Hospital, Alpert Medical School of Brown University, Providence, RI.
    The autoimmune cytopenias are a related group of disorders in which differentiated hematopoietic cells are destroyed by the immune system. Single lineage disease is characterized by the production of autoantibodies against red cells (autoimmune hemolytic anemia [AIHA]), platelets (autoimmune thrombocytopenia [ITP]) and neutrophils (autoimmune neutropenia [AIN]) whereas multilineage disease may include various combinations of these conditions. Central to the genesis of this disease is the breakdown of central and/or peripheral tolerance, and the subsequent production of autoantibodies by both tissue and circulating self-reactive B lymphocytes with support from T helper lymphocytes. Read More

    Influence of factor VIII level and its inhibitor titer on the therapeutic response to corticosteroids alone in the management of acquired hemophilia: A retrospective single-center study.
    Medicine (Baltimore) 2016 Nov;95(48):e5232
    aDepartment of Internal Medicine bDepartment of Biostatistics and Clinical Research cHaematology Laboratory and Haemophilia Reference Centre dDepartment of Clinical Haematology, Centre Hospitalier Universitaire de Caen, Caen, France.
    The treatment of acquired hemophilia (AH) involves discussing whether corticosteroids should be administered alone or combined with immunosuppressant drugs, which increase the risk of infection especially in elderly patients and/or those with autoimmunity or neoplastic diseases, who represent the target population of the disease. Prognostic factors highlighting adequate responses to corticosteroids alone must be identified for satisfactory clinical response and lower infectious risk.We aimed to evaluating the efficacy of corticosteroids alone in the management of AH depending on factor VIII (FVIII, ≥ or <1 IU/dL) levels and/or inhibitor (INH, ≤ or >20 Bethesda units per milliliter [BU/mL]) titer. Read More

    The protective and hemodynamic effects of dexmedetomidine on hypertensive cerebral hemorrhage patients in the perioperative period.
    Exp Ther Med 2016 Nov 16;12(5):2903-2908. Epub 2016 Sep 16.
    Department of Neurosurgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
    The aim of the present study was to analyze the protective and hemodynamic effects of dexmedetomidine in hypertensive cerebral hemorrhage (HCH) patients during perioperative period. In total, 50 HCH patients were selected and randomly divided into two groups, one group was administered with dexmedetomidine and the other groups with midazolam. The mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SpO2) were monitored in the two groups of patients before and during the operation. Read More

    Imaging findings of adrenal primitive neuroectodermal tumors: a series of seven cases.
    Clin Transl Oncol 2017 May 23;19(5):641-649. Epub 2016 Nov 23.
    Departments of General Surgery, Xiangya Hospital, Central South University, Hunan, People's Republic of China.
    Objective: To explore the imaging features of adrenal primitive neuroectodermal tumors (PNETs).

    Materials And Methods: This retrospective study included seven patients with surgically and pathologically confirmed adrenal PNETs. Among them, six underwent computed tomography (CT) scans, and one underwent magnetic resonance imaging. Read More

    Adrenal crisis secondary to bilateral adrenal haemorrhage after hemicolectomy.
    Endocrinol Diabetes Metab Case Rep 2016 25;2016. Epub 2016 Oct 25.
    Department of Surgery, Royal North Shore Hospital, St Leonards, New South Wales, Australia; The University of Sydney, Sydney, Australia.
    Adrenal haemorrhage is a rare cause of adrenal crisis, which requires rapid diagnosis, prompt initiation of parenteral hydrocortisone and haemodynamic monitoring to avoid hypotensive crises. We herein describe a case of bilateral adrenal haemorrhage after hemicolectomy in a 93-year-old female with high-grade colonic adenocarcinoma. This patient's post-operative recovery was complicated by an acute hypotensive episode, hypoglycaemia and syncope, and subsequent computed tomography (CT) scan of the abdomen revealed bilateral adrenal haemorrhage. Read More

    Acquired haemophilia A: an unusual postoperative complication.
    BMJ Case Rep 2016 Nov 16;2016. Epub 2016 Nov 16.
    University of Alabama School of Medicine, Montgomery, Alabama, USA.
    An African-American man aged 65 years with multiple malignancies in remission was admitted for small bowel obstruction. He was treated with laparotomy following failure of conservative management. Postoperatively, he developed intra-abdominal bleed, which persisted, despite surgical haematoma evacuation. Read More

    Hemodynamic Effects of Topical Adrenaline During Septoplasty.
    Indian J Otolaryngol Head Neck Surg 2016 Dec 8;68(4):391-395. Epub 2014 Aug 8.
    Department of Otorhinolaryngology-Head and Neck Surgery, Adnan Menderes University Medical Faculty, Aydın, Turkey.
    Vasoconstrictors agents is used in septal surgery, in attempt to improve haemostasis and thereby improve the surgical field. We aimed to compare the effect of lignocaine with adrenaline injection and alone lignocaine injection with topical adrenalin on perioperative hemodynamic effect, hemorrhage and postoperative pain. Patients undergoing surgery were randomised into two groups: group I in whom infiltration was performed with lignocaine (2 %) with adrenaline (1:100,000), group II in whom infiltration was performed with lignocaine (2 %) injection with topical adrenalin application (1:10,000). Read More

    Plasma Exchange in the Management of Catastrophic Antiphospholipid Syndrome.
    Case Rep Crit Care 2016 19;2016:5375080. Epub 2016 Oct 19.
    Nephrology, Dialysis and Transplantation Department, Amiens University Medical Center, Amiens, France.
    Objective. Report of a case of catastrophic antiphospholipid syndrome (CAPS) with multiple organ involvement leading to a life-threatening condition despite early combination corticosteroid and heparin therapy. Initiation of plasma exchange led to rapid improvement of the patient's general condition. Read More

    Pheochromocytoma Multisystem Crisis Triggered by Glucocorticoid Administration and Aggravated by Citrate Dialysis.
    A A Case Rep 2017 Feb;8(3):58-60
    From the Departments of *Anaesthesiology and †Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore.
    Pheochromocytoma multisystem crisis is the most severe presentation of pheochromocytoma. We report on a 68-year-old survivor of pheochromocytoma multisystem crisis, whose clinical course was triggered inadvertently by a short innocuous course of oral dexamethasone to suppress inflammation and swelling after a left orbital floor fracture repair. He presented first with severe epigastric pain and headache, and subsequently experienced insults to neurological, cardiac, respiratory, hepatobiliary, renal, and immune system in his prolonged intensive care unit stay. Read More

    Hydralazine-Induced ANCA Vasculitis in the Setting of Acute Clostridium Difficile Infection.
    R I Med J (2013) 2016 Nov 1;99(11):41-43. Epub 2016 Nov 1.
    Kent County Hospital, Warwick, RI.
    We report a rare case of Hydralazine-induced ANCA associated glomerulonephritis with alveolar hemorrhage in the setting of acute Clostridium Difficile Infection. A 71-year-old Caucasian woman with hypertension, who was being treated with hydralazine 25 mg twice a day for six years, presented to the hospital with diarrhea, nausea, vomiting and anemia. She had acute kidney injury and urinalysis showed proteinuria, dysmorphic RBCs, and rare RBC cast. Read More

    Extracorporeal Membrane Oxygenation for Treatment of Acute Inverted Takotsubo-Like Cardiomyopathy From Hemorrhagic Pheochromocytoma in Late Pregnancy.
    A A Case Rep 2016 Nov;7(9):196-199
    From the *Institute for Anesthesiology & Intensive Care Medicine, Triemli Hospital, Zürich, Switzerland; and †Clinic for Cardiac Surgery, Triemli Hospital, Zürich, Switzerland.
    We describe the first case of a pregnant woman presenting with an acute inverted takotsubo-like cardiomyopathy caused by a postpartum diagnosed hemorrhagic pheochromocytoma, successfully treated with percutaneous venoarterial extracorporeal membrane oxygenation (va-ECMO). During admission, an emergency cesarean delivery had to be performed. The fetus needed resuscitation for 5 minutes. Read More

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