7,706 results match your criteria Adrenal Hemorrhage


Gastrointestinal Stromal Tumor: GIST Another Duodenal Ulcer.

Ochsner J 2020 ;20(2):236-238

Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL.

Gastrointestinal stromal tumors (GISTs), although exceedingly rare, are the most common mesenchymal tumors in the gastrointestinal (GI) tract. GISTs are often asymptomatic; approximately 10% are found incidentally on imaging or endoscopy for other indications, although GI bleeding, intestinal obstruction, and perforation can occur. We present a case of upper GI bleeding from a duodenal GIST. Read More

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http://dx.doi.org/10.31486/toj.18.0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310177PMC
January 2020

Bilateral adrenal haemorrhage secondary to rivaroxaban in a patient with antiphospholipid syndrome.

BMJ Case Rep 2020 Jul 1;13(7). Epub 2020 Jul 1.

Internal Medicine and Pediatrics, Jackson Memorial Hospital, Miami, Florida, USA.

A 46-year-old man with antiphospholipid syndrome (APS) and previous pulmonary embolism on anticoagulation with rivaroxaban was brought in to the hospital after a syncopal episode. He was found to be hypotensive and tachycardic and later admitted to the intensive care unit. Clinical presentation and laboratory findings were consistent with adrenal insufficiency. Read More

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http://dx.doi.org/10.1136/bcr-2020-234947DOI Listing

Tyrosine Kinase Inhibitors' Newly Reported Endocrine Side Effect: Pazopanib-Induced Primary Adrenal Insufficiency in a Patient With Metastatic Renal Cell Cancer.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620936808

University of Arizona, Phoenix, AZ, USA.

Tyrosine kinase inhibitors (TKIs) have been used in the treatment of multiple types of cancer. Pazopanib is one of the TKIs and is considered a first-line treatment for adult patients with metastatic renal cell carcinoma. Many endocrine-related adverse effects have been noted with the use of TKIs including hypothyroidism, vitamin D deficiency, altered bone density, secondary hyperparathyroidism, abnormal glucose metabolism, gynecomastia, and hypogonadism. Read More

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http://dx.doi.org/10.1177/2324709620936808DOI Listing

A rare long-term undetected pheochromocytoma leading to Takotsubo syndrome in an older male patient: a case report.

BMC Endocr Disord 2020 Jun 23;20(1):93. Epub 2020 Jun 23.

Department of Cardiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, #79, Qingchun Road, Zhejiang, 310003, Hangzhou, China.

Background: Takotsubo syndrome is an uncommon, acute, and reversible cardiomyopathy that occurs primarily in postmenopausal females. The clinical presentation of the syndrome resembles acute coronary syndrome, but coronary angiography reveals no obstructive coronary artery disease. Rarely, a catecholamine surge due to pheochromocytoma may induce Takotsubo syndrome. Read More

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http://dx.doi.org/10.1186/s12902-020-00578-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313138PMC

Adrenal Insufficiency Secondary to Bilateral Adrenal Hemorrhage: A Case Report.

Cureus 2020 Jun 13;12(6):e8596. Epub 2020 Jun 13.

Diabetes and Endocrinology, Peterborough City Hospital, Peterborough, GBR.

Acute adrenal hemorrhage (adrenal apoplexy) in the context of severe sepsis is potentially life-threatening. Diagnosis of this condition is difficult to achieve without a strong sense of suspicion. The concurrent use of anticoagulants increases the risk of adrenal hemorrhage in the context of sepsis. Read More

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http://dx.doi.org/10.7759/cureus.8596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294864PMC

BILATERAL ADRENAL HEMORRHAGE WITH ADRENAL INSUFFICIENCY AFTER DALTEPARIN USE POST HIP ATHROPLASTIES.

AACE Clin Case Rep 2020 May-Jun;6(3):e141-e143. Epub 2020 May 8.

Objective: Multiple case reports have implicated the use of heparin for deep vein thrombosis (DVT) prophylaxis with bilateral adrenal hemorrhage. Only 1 previous report has described this with the low molecular weight product, dalteparin. We report a case following bilateral hip arthroplasties. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282283PMC

ADRENAL INSUFFICIENCY SECONDARY TO BILATERAL ADRENAL HEMORRHAGE ASSOCIATED WITH ANTIPHOSPHOLIPID SYNDROME.

AACE Clin Case Rep 2020 Mar-Apr;6(2):e65-e69. Epub 2019 Dec 20.

Objective: Antiphospholipid syndrome (APS) can involve multiple organ systems but endocrine manifestations are rare. In most cases adrenal insufficiency (AI) is the first endocrine manifestation of APS. The prompt diagnosis of AI is critical as this disorder is a life-threatening disease that may lead to fatal outcomes if left untreated. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282157PMC
December 2019

Over-the-Scope Clip to the Rescue! A Novel Tool for Refractory Acute Nonvariceal Upper Gastrointestinal Hemorrhage.

Case Rep Gastroenterol 2020 May-Aug;14(2):261-270. Epub 2020 May 12.

Department of Gastroenterology, Staten Island University Hospital, Northwell Health, Staten Island, New York, USA.

Nonvariceal upper gastrointestinal hemorrhage (NVUGIH) is more prevalent than lower gastrointestinal hemorrhage and carries a high risk of mortality in the elderly, especially those with significant cardiovascular comorbidities. Traditional endoscopic methods, such as through-the-scope clips, electrocautery, and epinephrine injection, are frequently used to control these bleeds; however, they carry a 10% risk of rebleeding, and this itself carries a mortality risk of 36%. The larger over-the-scope clips (OTSC) that were initially used for the closure of fistulas and perforations are now gradually being implemented to manage NVUGIH. Read More

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http://dx.doi.org/10.1159/000507610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265719PMC

Retrospective comparison of three minimally invasive approaches for adrenal tumors: perioperative outcomes of transperitoneal laparoscopic, retroperitoneal laparoscopic and robot-assisted laparoscopic adrenalectomy.

BMC Urol 2020 Jun 9;20(1):66. Epub 2020 Jun 9.

Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, 321 Zhongshan Rd, Nanjing, 210008, Jiangsu, People's Republic of China.

Background: To compare the perioperative outcomes of transperitoneal laparoscopic (TLA), retroperitoneal laparoscopic (RLA), and robot-assisted transperitoneal laparoscopic (RATLA) adrenalectomy for adrenal tumors in our center.

Methods: Between April 2012 and February 2018, 241 minimally invasive adrenalectomies were performed. Cases were categorized based on the minimally invasive adrenalectomy technique. Read More

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http://dx.doi.org/10.1186/s12894-020-00637-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285739PMC

Management of acute limb ischemia related to underlying pheochromocytoma.

J Vasc Surg Cases Innov Tech 2020 Jun 15;6(2):272-276. Epub 2020 Apr 15.

Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif.

Acute limb ischemia (ALI) related to pheochromocytoma is rare. We describe a 69-year-old woman who presented with ALI due to a thromboembolic phenomenon from new-onset atrial fibrillation that was successfully treated with intra-arterial catheter-directed lysis and systemic anticoagulation. Further workup revealed a left adrenal mass and biochemical test results consistent with pheochromocytoma. Read More

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http://dx.doi.org/10.1016/j.jvscit.2020.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264002PMC

A rare case of adrenal collision tumor: Myelolipoma and schwannoma in the adrenal gland.

SAGE Open Med Case Rep 2020 9;8:2050313X20921074. Epub 2020 May 9.

Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA.

Adrenal collision tumors refer to coexistence of two adjacent, but histologically distinct, neoplasms involving the adrenal gland without histologic admixture at the interface. Myelolipoma is a rare but benign neoplasm. As its name implies, displays both mature adipose tissue and hematopoietic elements. Read More

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http://dx.doi.org/10.1177/2050313X20921074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234350PMC

Retroperitoneoscopy in the horse: Anatomical study of the retroperitoneal perirenal space and description of a surgical approach.

Equine Vet J 2020 May 30. Epub 2020 May 30.

Department of Surgery, Equine Clinic, ONIRIS, National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.

Background: Surgical approaches to the kidneys and perirenal structures are uncommonly performed in horses and several complications have been described with the current procedures.

Objective: To describe the anatomy of the retroperitoneal perirenal space and investigate a retroperitoneal minimally invasive approach to access the kidney and perirenal structures in horses.

Study Design: Descriptive, cadaveric study. Read More

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http://dx.doi.org/10.1111/evj.13293DOI Listing

CT and MR imaging of acute adrenal disorders.

Abdom Radiol (NY) 2020 May 26. Epub 2020 May 26.

The Ottawa Hospital, the University of Ottawa, 1053 Carling Avenue, Ottawa, ON, K1Y 4E9, Canada.

The adrenal glands may be overlooked when evaluating acutely ill patients. Acute adrenal disorders may result from complications of an underlying systemic disease, which may be unsuspected clinically. Various acute adrenal emergencies including trauma, spontaneous hemorrhage, infarction and infection can be diagnosed using CT and MRI; however, in uncertain cases follow-up to resolution of imaging findings or histological sampling may be required for diagnosis. Read More

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http://dx.doi.org/10.1007/s00261-020-02580-wDOI Listing

Resected case of stage IV pleomorphic carcinoma of the lung with long-term survival.

Surg Case Rep 2020 May 24;6(1):106. Epub 2020 May 24.

Department of Thoracic Surgery, Iwakuni Clinical Center, 1-1-1 Atago-machi, Iwakuni-shi, Yamaguchi, 740-8510, Japan.

Background: No established treatments for pulmonary pleomorphic carcinoma exist because of its rarity, and the prognosis is poorer than that of other non-small cell lung cancers.

Case Report: We present a case of stage IV pleomorphic carcinoma; the patient was a 66-year-old male. He was referred to our hospital because of a right adrenal hemorrhage and a lung tumor. Read More

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http://dx.doi.org/10.1186/s40792-020-00868-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246230PMC

Computed tomography findings of early-stage TAFRO syndrome and associated adrenal abnormalities.

Eur Radiol 2020 May 21. Epub 2020 May 21.

Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Objectives: To compare CT findings of early (within 3 weeks post-onset)- and later (within 1 month before or after diagnostic criteria were satisfied, and later than 3 weeks post-onset) stage thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome.

Methods: Between 2014 and 2019, 13 patients with TAFRO syndrome (8 men and 5 women; mean age, 54.9 years) from nine hospitals were enrolled. Read More

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http://dx.doi.org/10.1007/s00330-020-06919-1DOI Listing
May 2020
4.014 Impact Factor

Spontaneous hemorrhage of an adrenal myelolipoma treated with transarterial embolization: A case report.

Radiol Case Rep 2020 Jul 7;15(7):961-965. Epub 2020 May 7.

Department of Radiology, Section of Vascular and Interventional Radiology, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA.

Adrenal myelolipoma is a benign tumor of the adrenal cortex composed predominantly of fat and hematopoietic tissue. These lesions are usually asymptomatic, and most often incidentally detected on imaging. Uncommonly, they present with retroperitoneal hemorrhage, and these have been traditionally treated with emergent surgery. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214766PMC

An Autopsy Case of Mixed Connective Tissue Disease Complicated by Thrombotic Thrombocytopenic Purpura.

Intern Med 2020 15;59(10):1315-1321. Epub 2020 May 15.

Department of Rheumatology, Fukushima Medical University School of Medicine, Japan.

We herein report a patient with mixed connective tissue disease (MCTD) who had been stable for years but suddenly developed thrombotic thrombocytopenic purpura (TTP). The patient showed a clinical pentad of signs of TTP, low activity of ADAMTS13, and positivity of anti-ADAMTS13 antibodies. She did not respond to plasma exchange or steroid therapy and died five days after admission. Read More

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http://dx.doi.org/10.2169/internalmedicine.3939-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303452PMC

When a crisis hits: bilateral adrenal haemorrhage - a case report.

Clin Med (Lond) 2020 Mar;20(Suppl 2):s40

Oxford University Hospitals NHS Trust, Oxford, UK.

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http://dx.doi.org/10.7861/clinmed.20-2-s40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243557PMC

Over-The-Scope Clip system as a first-line therapy for high-risk bleeding peptic ulcers: a retrospective study.

Surg Endosc 2020 May 11. Epub 2020 May 11.

Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas, Av. Abel Romero Castillo S/N y Av. Juan Tanca Marengo, Torre Vitalis I, Mezanine 3, 090505, Guayaquil, Ecuador.

Background: Effective hemostasis is essential to prevent rebleeding. We evaluated the efficacy and feasibility of the Over-The-Scope Clip (OTSC) system compared to combined therapy (through-the-scope clips with epinephrine injection) as a first-line endoscopic treatment for high-risk bleeding peptic ulcers.

Methods: We retrospectively analyzed data of 95 patients from a single, tertiary center and underwent either OTSC (n = 46) or combined therapy (n = 49). Read More

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http://dx.doi.org/10.1007/s00464-020-07625-1DOI Listing

Results of Percutaneous Computed Tomography-Guided Biopsy of Adrenal Lesions and Spectrum of Computed Tomography Findings.

J Clin Imaging Sci 2020 6;10:16. Epub 2020 Apr 6.

Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Objective: Adrenal enlargement occurs in various conditions such as infections, benign, and malignant neoplasms. Percutaneous computed tomography (CT)-guided adrenal biopsy is a safe method for obtaining tissue specimen in cases where diagnosis cannot be established on imaging and biochemical grounds. The study aims to evaluate diagnostic yield, accuracy, and complications of percutaneous CT-guided adrenal biopsies. Read More

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http://dx.doi.org/10.25259/JCIS_3_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193151PMC

Precocious ischemia preceding bilateral adrenal hemorrhage: A case report.

Radiol Case Rep 2020 Jun 21;15(6):803-807. Epub 2020 Apr 21.

Institute of Biostructures and Bioimaging of the National Council of Research (CNR), Naples, Italy.

We present a case of a middle-age male who presented in emergency room with nonspecific abdominal pain. A contrast-enhanced computer tomography (ceCT) scan showed a reduced perfusion of both adrenal glands. The clinical examinations and the laboratory tests were negative for an adrenal pathological process. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178323PMC

Massive Pulmonary Hemorrhage from Bronchial Varix.

Case Rep Pulmonol 2020 4;2020:9175785. Epub 2020 Apr 4.

Guam Regional Medical City Intensive Care Unit, 133 Route 3, 96929 Dededo, Guam, USA.

Bronchial varix is a rare pulmonary disorder which may lead to life-threatening hemorrhage. Diagnosis is difficult because of the subtle abnormalities on radiographic and bronchoscopic examination. We present a case of massive hemoptysis from a bleeding bronchial varix. Read More

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http://dx.doi.org/10.1155/2020/9175785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160734PMC

Haemorrhage in pre-existing adrenal masses. A case series.

Int J Surg Case Rep 2020 2;69:76-78. Epub 2020 Apr 2.

Third Department of Surgery, Athens General Hospital "G. Gennimatas", Mesogeion Avenue 154, Athens, Greece.

Introduction: Adrenal haemorrhage in the context of a pre-existing adrenal mass is a rare, underestimated and potentially fatal surgical emergency. It is a rare cause of acute abdominal pain.

Presentation Of Cases: Data from 13 patients with adrenal haemorrhage in a pre-existing adrenal mass were prospectively collected during a 9 year period from a single institution. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163044PMC

A pictorial review of non-traumatic adrenergic crisis.

Emerg Radiol 2020 Apr 16. Epub 2020 Apr 16.

Ohio State University Wexner Medical Center, Columbus, OH, USA.

Non-traumatic adrenal crisis is a rare but critical diagnosis to make in emergency settings due to grave consequences. Various pathologies can present as acute crisis, such as spectrum of endocrine imbalance, ranging from catecholamine excess in pheochromocytomas to acute adrenal insufficiency related to glandular dysfunction. Critical manifestations may be due to structural causes related to adrenal hemorrhage, especially when they are bilateral. Read More

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http://dx.doi.org/10.1007/s10140-020-01777-2DOI Listing

Traumatic Adrenal Hemorrhage Masking as a Pseudotumor.

Cureus 2020 Mar 13;12(3):e7256. Epub 2020 Mar 13.

Trauma Critical Care/Surgery, East Tennessee State University, Johnson City, USA.

Several case reports have been filed regarding the latent presentation of hemorrhagic pheochromocytomas in the trauma setting; however, few patients have been found to exhibit these symptoms in the absence of a tumor. In this report, we discuss a patient who sustained blunt abdominal trauma leading to the development of an adrenal hemorrhage and his unexpected sequelae of symptoms. Discovery of the source of the patient's symptoms was delayed secondary to multiple comorbidities in the critical care setting and work-up for other sources such as infection and agitation. Read More

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http://dx.doi.org/10.7759/cureus.7256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152569PMC

Clinical course of adrenal myelolipoma: A long-term longitudinal follow-up study.

Clin Endocrinol (Oxf) 2020 Jul 23;93(1):11-18. Epub 2020 Apr 23.

Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN, USA.

Objective: We aimed to describe clinical course of myelolipoma and to identify predictors of tumour growth and need for surgery.

Design: A retrospective study.

Patients: Consecutive patients with myelolipoma. Read More

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http://dx.doi.org/10.1111/cen.14188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292791PMC

Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with Bilateral Adrenal Hemorrhage in Two Caucasian Patients.

Am J Case Rep 2020 Apr 6;21:e919536. Epub 2020 Apr 6.

Department of Internal Medicine, Edouard Herriot Hospital, Lyon, France.

BACKGROUND Thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly (TAFRO) syndrome is a variant of idiopathic multicentric Castleman disease. Adrenal hemorrhage has rarely been reported in TAFRO syndrome, and previous cases have mainly been Asian patients. This report is of two Caucasian patients with TAFRO syndrome presenting with acute adrenal insufficiency due to bilateral adrenal hemorrhage. Read More

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http://dx.doi.org/10.12659/AJCR.919536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161919PMC

Comparing Hemorrhage in Human Physiology Simulation Tools: How They Compare With Expected Human Physiology and Each Other.

Simul Healthc 2020 Mar 25. Epub 2020 Mar 25.

From the Department of Anesthesiology (J.J.B., K.K., M.R.K), Simulation PeriOperative Resource for Training and Learning (SimPORTAL) University of Minnesota, Minneapolis, Minnesota; Department of Urology (R.S.), and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (J.K.), WWAMI Institute for Simulation in Healthcare (WISH), University of Washington, Seattle, Washington.

Introduction: Several different whole-body physiology simulation tools (PST) using modeling techniques are now available with potential use for healthcare simulation, but these novel technologies lack objective analysis from an independent organization.

Methods: We identified BioGears, HumMod, and Muse as 3 PSTs that met our requirements for testing. We ran mild, moderate, and severe hemorrhage scenarios on each PST and collected outputs for comparison with each other and published human physiology data. Read More

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http://dx.doi.org/10.1097/SIH.0000000000000427DOI Listing

Unusual case of antiphospholipid syndrome presenting as adrenal insufficiency.

BMJ Case Rep 2020 Mar 17;13(3). Epub 2020 Mar 17.

Internal Medicine, University Hospital Limerick, Dooradoyle, Limerick, Ireland.

A 64-year-old man presented to the emergency department with generalised fatigue and dizzy spells. His background history includes a previous admission with right leg deep vein thrombosis, provoked by pneumonia. Laboratory results showed evidence of hyponatremia and hyperkalaemia. Read More

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http://dx.doi.org/10.1136/bcr-2019-233631DOI Listing

Effectiveness of tumescent solution combined with negative pressure wound therapy in traditional high ligation and stripping of the great saphenous vein.

Medicine (Baltimore) 2020 Mar;99(11):e19040

Department of Vascular Surgery, Drum Tower Clinical Medicine College of Nanjing Medical University.

Traditional high ligation and stripping (THLS) is a routine operation for varicose veins. However, THLS is accompanied with postoperative subcutaneous ecchymosis and pain. In this current study, we aimed to explore the effect of tumescence solution (TS) combined with negative pressure wound therapy (NPWT) on the relief of subcutaneous ecchymosis and pain after THLS of great saphenous vein. Read More

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http://dx.doi.org/10.1097/MD.0000000000019040DOI Listing

Open adrenalectomy: A 20-year review of our experience in a developing country.

Ann Afr Med 2020 Jan-Mar;19(1):26-30

Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Farabi Hospital, Karadeniz Technical University, Trabzon, Turkey.

Introduction: The aim of this study was to present our 20-year experience regarding open adrenalectomy (OA) during laparoscopic era in a developing country Turkey.

Materials And Methods: A retrospective and descriptive study of patients with adrenal mass undergoing OA in the surgery department of our hospital, between January 1993 and January 2013, was carried out. All operations were performed by two surgeons. Read More

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http://dx.doi.org/10.4103/aam.aam_10_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189884PMC

High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies.

Nat Biomed Eng 2020 03 12;4(3):286-297. Epub 2020 Mar 12.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The monitoring of vascular-targeted therapies using magnetic resonance imaging, computed tomography or ultrasound is limited by their insufficient spatial resolution. Here, by taking advantage of the intrinsic optical properties of haemoglobin, we show that raster-scanning optoacoustic mesoscopy (RSOM) provides high-resolution images of the tumour vasculature and of the surrounding tissue, and that the detection of a wide range of ultrasound bandwidths enables the distinction of vessels of differing size, providing detailed insights into the vascular responses to vascular-targeted therapy. Using RSOM to examine the responses to vascular-targeted photodynamic therapy in mice with subcutaneous xenografts, we observed a substantial and immediate occlusion of the tumour vessels followed by haemorrhage within the tissue and the eventual collapse of the entire vasculature. Read More

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http://dx.doi.org/10.1038/s41551-020-0527-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153756PMC

[Role and mechanism of splenic myeloid-derived suppressor cells in sepsis-induced adrenal injury in mice].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Jan;32(1):33-38

Department of Critical Care Medicine, the First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu 241000, Anhui, China.

Objective: To investigate the role and mechanism of splenic myeloid-derived suppressor cells (MDSCs) in sepsis-induced adrenal injury (SAI).

Methods: Thirty male C57 mice aged 6-8 weeks were randomly divided into normal control group (n = 5), sham operation group (Sham group, n = 5), sepsis model group [cecal ligation and perforation (CLP) group, n = 10] and sepsis+splenectomy group (CLPS group, n = 10). The sepsis model of mice was reproduced by CLP method. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20190725-00006DOI Listing
January 2020

Outcome in dogs undergoing adrenalectomy for small adrenal gland tumours without vascular invasion.

Vet Comp Oncol 2020 Mar 5. Epub 2020 Mar 5.

VCA Canada-404 Veterinary Emergency and Referral, Newmarket, Ontario, Canada.

Veterinary studies have reported the outcome of adrenalectomies in dogs; however, these studies typically include a wide variety of adrenal tumour sizes, including cases with or without vascular invasion. The purpose of this study was to report outcome in a cohort of dogs with histologically confirmed small adrenal tumours without vascular invasion treated with adrenalectomy. This retrospective study was conducted using data from the University of Florida and University of California-Davis databases between 2010 and 2017. Read More

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http://dx.doi.org/10.1111/vco.12587DOI Listing

Multiple trauma including pelvic fracture with multiple arterial embolization: an autopsy case report.

Thromb J 2020 2;18. Epub 2020 Mar 2.

1Advanced Critical Care Center, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194 Japan.

Background: Pelvic fracture with high energy trauma has a high mortality rate, especially in men. In addition, severe multiple trauma, major hemorrhage, and administration of red blood cells predict mortality in elderly patients with pelvic fracture. We herein report a rare case in which multiple arterial embolization occurred after pelvic fracture. Read More

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http://dx.doi.org/10.1186/s12959-020-00217-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050116PMC

Carpal Tunnel Release without a Tourniquet: A Systematic Review and Meta-Analysis.

Plast Reconstr Surg 2020 03;145(3):737-744

Hamilton and Toronto, Ontario, Canada From the Michael G. DeGroote School of Medicine, the Department of Health Research Methods, Evidence and Impact, and the Division of Plastic Surgery, Department of Surgery, McMaster University; and the Faculty of Health, York University.

Background: Open carpal tunnel release is commonly performed with the use of a tourniquet. The combination of local anesthetic and epinephrine with a pneumatic tourniquet helps provide clear visualization during decompression of the median nerve. There has been a rapid expansion of literature challenging the use of tourniquets in open carpal tunnel release. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006549DOI Listing

Low-intensity focused ultrasound stimulation treatment decreases blood pressure in spontaneously hypertensive rats.

IEEE Trans Biomed Eng 2020 Feb 20. Epub 2020 Feb 20.

Objective: We applied low-intensity focused ultrasound (LIFU) stimulation of the ventrolateral periaqueductal gray (vlPAG) in spontaneously hypertensive rats (SHRs) model to demonstrate the feasibility of LIFU stimulation to decrease blood pressure (BP).

Methods: The rats were treated with LIFU stimulation for 20 min every day for one week. The change of BP and heart rate (HR) were recorded to evaluate the antihypertensive effect. Read More

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http://dx.doi.org/10.1109/TBME.2020.2975279DOI Listing
February 2020

Histopathological Evidence of Multiple Organ Damage After Simulated Aeromedical Evacuation in a Swine Acute Lung Injury Model.

Mil Med 2020 01;185(Suppl 1):57-66

Neuro Trauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910.

Introduction: Rapid aeromedical evacuation (AE) is standard of care in current conflicts. However, not much is known about possible effects of hypobaric conditions. We investigated possible effects of hypobaria on organ damage in a swine model of acute lung injury. Read More

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http://dx.doi.org/10.1093/milmed/usz248DOI Listing
January 2020

Thrombolysis in Postoperative Pulmonary Embolism Following Liver Transplantation: A Case Report.

Am J Case Rep 2020 Feb 18;21:e918857. Epub 2020 Feb 18.

Department of General and Transplant Surgery, Jordan Hospital, Amman, Jordan.

BACKGROUND Postoperative pulmonary embolism following liver transplantations is still one of the most fatal complications, especially during the early postoperative phase. The use of a thrombolytic agent such as the recombinant tissue-type plasminogen activator (rtPA) is considered a contraindication early after major abdominal surgery such as liver transplantation. However, thrombolysis after major surgery in the early postoperative period carries a substantial risk of surgical site hemorrhage. Read More

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http://dx.doi.org/10.12659/AJCR.918857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048324PMC
February 2020

Normal size of the fetal adrenal gland on prenatal magnetic resonance imaging.

Pediatr Radiol 2020 May 14;50(6):840-847. Epub 2020 Feb 14.

Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA.

Background: The adrenal gland plays a vital role in fetal growth. Many disease states such as congenital adrenal hyperplasia, hemorrhage and tumors can lead to morphological changes in the gland. Ultrasound measurements of normal adrenal sizes in the fetus reported in the literature have shown a trend of increasing size with gestational age. Read More

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http://dx.doi.org/10.1007/s00247-020-04629-wDOI Listing

The Risk of Corticosteroids in Community-Acquired Pneumonia.

Am Fam Physician 2020 02;101(4):197

Nashville, TN, USA.

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February 2020

Hemodynamic stability during adrenalectomy for pheochromocytoma: A case control study of posterior retroperitoneal vs lateral transperitoneal approaches.

Medicine (Baltimore) 2020 Feb;99(7):e19104

Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu.

Hemodynamic stability is one of the most critical aspects of adrenal surgery for pheochromocytoma. Few articles have evaluated the hemodynamic status of patients undergoing posterior retroperitoneal adrenalectomy (PRA) for pheochromocytoma. The aim of this study is to compare the intraoperative hemodynamic parameters between lateral transperitoneal adrenalectomy (TPA) and PRA in this groups of patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000019104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035043PMC
February 2020

Temporal trend of diabetes in pregnant women and its association with birth outcomes, 2011 to 2017.

J Diabetes Complications 2020 Apr 24;34(4):107550. Epub 2020 Jan 24.

University of New South Wales, Sydney, Australia; Agency for Clinical Innovation, NSW Health, Australia. Electronic address:

Aim: To assess changes in the prevalence of diabetes in pregnant women, and its association with selected birth outcomes (including caesarean section, episiotomy, admission to the special care nursery/neonatal intensive care unit, postpartum haemorrhage and neonatal birth weight) from 2011 to 2017.

Methods: In a single-centre, retrospective cohort study, we examined records of pregnant women who attended an Australian tertiary hospital between 2011 and 2017, identifying women with gestational diabetes mellitus and pre-existing diabetes mellitus, and examined trends associated with diabetes and their effects on birth outcomes.

Results: The average incidence of women with diabetes increased by 9% annually (RR = 0. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2020.107550DOI Listing

Risk factors for bleeding from gastrointestinal angiodysplasia: a case-control study in patients with bleeding and non-bleeding angiodysplasia.

Z Gastroenterol 2020 Mar 4;58(3):234-240. Epub 2020 Feb 4.

II. Medizinische Klinik, Krankenhaus Landshut, Germany.

Objectives:  Angiodysplasia (AD) is a common source of gastrointestinal bleeding. Yet, little is known about factors forwarding bleeding in these vascular malformations. The presented study aims to determine risk factors for bleeding that occurs only in patients with symptomatic, but not with asymptomatic, AD. Read More

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http://dx.doi.org/10.1055/a-1068-3014DOI Listing

Fatal and extensive multiorgan hemorrhages in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: An autopsy case report.

Medicine (Baltimore) 2020 Jan;99(3):e18600

Department of Rheumatology.

Introduction: Anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) is an autoantigen associated with dermatomyositis (DM). Anti-MDA5 Ab-positive DM patients frequently exhibit clinically amyopathic dermatomyositis (CADM), and develop rapidly progressive interstitial lung disease (RPILD). Even with early detection and potent combination immunosuppressive therapy, anti-MDA5 Ab-positive DM patients have a poor prognosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000018600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220071PMC
January 2020

Spontaneous adrenal hemorrhage and preeclampsia: A case report.

Saudi J Anaesth 2020 Jan-Mar;14(1):117-119. Epub 2020 Jan 6.

Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Spontaneous Adrenal Hemorrhage is a rare disease. It's one of the rare causes of abdominal pain late in pregnancy. I present a case with near term Spontaneous Adrenal Hemorrhage and concurrent severe preeclampsia, aiming to address the anesthetic considerations and management of such challenging presentation. Read More

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http://dx.doi.org/10.4103/sja.SJA_550_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970351PMC
January 2020

Imaging modalities and management of prenatally diagnosed suprarenal masses: an updated literature review and the experience at a high volume Fetal Treatment Center.

J Matern Fetal Neonatal Med 2020 Jan 26:1-8. Epub 2020 Jan 26.

Department of Surgery, University of California, San Francisco, CA, USA.

The differential diagnosis for prenatal suprarenal masses (SRMs) is broad and includes neuroblastoma, adrenal hemorrhage, and subdiaphragmatic extralobar pulmonary sequestration (SEPS). We sought to elucidate the appropriate postnatal management for fetuses found to have an SRM. We conducted a retrospective review of patients prenatally diagnosed with SRM at our institution between 1998 and 2018. Read More

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http://dx.doi.org/10.1080/14767058.2020.1716719DOI Listing
January 2020

EVOLVING ADRENAL DYSFUNCTION AFTER BILATERAL ADRENAL INFARCTION: A CASE REPORT.

AACE Clin Case Rep 2019 Nov-Dec;5(6):e334-e339. Epub 2019 Aug 15.

Objective: To describe a case of sequential bilateral adrenal infarction and hemorrhage resulting in an unusual pattern of adrenal function over time.

Methods: A 50-year-old male with autoimmune antiphospholipid syndrome (APS) presented to the emergency room with severe abdominal pain. Diagnostic studies performed included contrast-enhanced computerized tomographic (IV-CT) imaging of abdomen and pelvis, and laboratory assessment of the hypothalamic-pituitary-adrenal axis. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873843PMC

ADRENAL INSUFFICIENCY FROM UNILATERAL ADRENAL HEMORRHAGE IN A PATIENT ON RIVAROXABAN THROMBOPROPHYLAXIS.

AACE Clin Case Rep 2019 Jan-Feb;5(1):e70-e72. Epub 2019 Jan 30.

Objective: We report a case of unilateral adrenal hemorrhage resulting in adrenal insufficiency in a patient on rivaroxaban for thromboprophylaxis after total knee arthroplasty.

Methods: The clinical presentation, laboratory findings, and outcome of the case are described. An overview of the etiology, diagnosis, and treatment of adrenal hemorrhage is reviewed. Read More

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http://dx.doi.org/10.4158/ACCR-2018-0340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876984PMC
January 2019