104,047 results match your criteria Adrenal Gland


Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.

Liver Int 2019 Jan 21. Epub 2019 Jan 21.

Research Unit for Experimental and Molecular Hepatology.

Background And Aims: Bile acids are now accepted as central signaling molecules for the regulation of glucose, amino acid, and lipid metabolism. Adrenal gland cortex cells express the bile acid receptors farnesoid X receptor (FXR), the G protein-coupled bile acid receptor (TGR5), and the sphingosine-1-phosphate receptor 2 (S1PR2). We aimed to determine the effects of cholestasis and more specifically of bile acids on cortisol production. Read More

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http://dx.doi.org/10.1111/liv.14052DOI Listing
January 2019

Minimally invasive approach to the adrenal gland in obese patients with Cushing's syndrome.

Minim Invasive Ther Allied Technol 2019 Jan 19:1-7. Epub 2019 Jan 19.

a Clinica Chirurgica , Universita Politecnica delle Marche , Ancona , Italy.

Introduction: The combination of Cushing's syndrome and obesity, one of the most common manifestations of the syndrome itself, may be associated with the worsening of post-operative outcomes in case of laparoscopic adrenalectomy. This study focused on the laparoscopic treatment of Cushing's syndrome with the purpose to identify any relevant difference between morbidly obese, mildly obese and non-obese patients.

Material And Methods: Patients were retrospectively divided into three groups according to their Body Mass Index (BMI). Read More

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http://dx.doi.org/10.1080/13645706.2018.1536669DOI Listing
January 2019

The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins.

Front Pharmacol 2018 4;9:1515. Epub 2019 Jan 4.

Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, United States.

The mevalonate pathway provides sterols for membrane structure and nonsterol intermediates for the post-translational modification and membrane anchorage of growth-related proteins, including the Ras, Rac, and Rho GTPase family. Mevalonate-derived products are also essential for the Hedgehog pathway, steroid hormone signaling, and the nuclear localization of Yes-associated protein and transcriptional co-activator with PDZ-binding motif, all of which playing roles in tumorigenesis and cancer stem cell function. The phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT-mammalian target of rapamycin complex 1 pathway, p53 with gain-of-function mutation, and oncoprotein MYC upregulate the mevalonate pathway, whereas adenosine monophosphate-activated protein kinase and tumor suppressor protein RB are the downregulators. Read More

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http://dx.doi.org/10.3389/fphar.2018.01515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328495PMC
January 2019

Normal adrenal gland thickness on computerized tomography in an Asian Indian adult population.

Indian J Radiol Imaging 2018 Oct-Dec;28(4):465-469

Department of Endocrinology, Christian Medical College, Vellore, Tamil Nadu, India.

Context: The size and morphology of the adrenal glands are affected by several physiological and pathological conditions. Radiologists need to be aware of the normal thickness of adrenal gland to accurately assess patients with suspected adrenal pathology. However, there is limited data on the normal size of the adrenal glands. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_129_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319091PMC
January 2019

Dual liquid-liquid extraction followed by LC-MS/MS method for the simultaneous quantification of melatonin, cortisol, triiodothyronine, thyroxine and testosterone levels in serum: Applications to a photoperiod study in rats.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 3;1108:11-16. Epub 2019 Jan 3.

Education, Science and Sport Department, Castilla-La Mancha, Spain.

Hypothalamic Pituitary (PH) axes directly affects the functionality of the thyroid gland, the adrenal gland, and the gonads and their alteration has been related to several pathologies. Therefore, the global analysis of representative hormones from each axis, together with melatonin, would be a very good strategy for therapeutic diagnosis. Hence, an accurate, economic and effective analytical method has been developed and validated for the simultaneous measurement of the melatonin, cortisol, triiodothyronine (T3), thyroxine (T4) and testosterone levels in serum. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.01.002DOI Listing
January 2019

Pleural dedifferentiated liposarcoma: A case report.

Mol Clin Oncol 2019 Jan 5;10(1):132-136. Epub 2018 Nov 5.

Department of Pathology, Japan Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan.

The present case report describes a rare case of pleural liposarcoma. A 45-year-old Japanese man was hospitalized for increasing left chest pain. Imaging revealed a 10-cm pleural tumor and a 1. Read More

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http://dx.doi.org/10.3892/mco.2018.1757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313927PMC
January 2019

Left sided flank pain due to Bochdalek hernia with intrathoracic kidney.

Scand J Urol 2019 Jan 17:1-2. Epub 2019 Jan 17.

a Department of Urology , Rigshospitalet , Denmark.

A 40 year old woman had undergone surgery as a newborn due to a left sided congenital Bochdalek hernia with the ventricle, spleen, left kidney and adrenal gland located intrathoracically. After three pregnancies, she developed left sided flank pain and dyspnea. A CT scan showed a diaphragmatic hernia with a malrotated intrathoracic placed left kidney with minimal hydronephrosis. Read More

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http://dx.doi.org/10.1080/21681805.2018.1545798DOI Listing
January 2019

Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14063

Department of Surgery.

Rationale: The brain, liver, adrenal glands, and bone are the most common sites of metastatic disease in patients with lung cancer. Symptomatic gastrointestinal metastases are rare. In the present report, we describe a rare case of a patient with intestinal obstruction due to solitary colonic metastasis from primary lung adenocarcinoma, wherein the intestinal obstruction was the first symptom of lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014063DOI Listing
January 2019

Seminal vesicle metastasis after liver transplantation for hepatocellular carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e13770

Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School.

Rationale: Cancer recurrence and metastasis after liver transplantation (LT) is common in some hepatocellular carcinoma (HCC) patients. The most common sites of extrahepatic metastases are lung, regional lymph node, adrenal gland, and bone. To our knowledge, HCC metastasis to the seminal vesicle after LT has not been reported in the literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000013770DOI Listing
January 2019

Which sympathoadrenal abnormalities of adult spontaneously hypertensive rats can be traced to a prehypertensive stage?

Hypertens Res 2019 Jan 16. Epub 2019 Jan 16.

Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

Alterations of sympathoadrenal and sympathoneural systems have been suggested to be involved in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR). To evaluate the ontogenetic changes of these systems, mRNA and protein expressions of catecholaminergic system genes were measured in adrenal glands and sympathetic ganglia, and the catecholamine levels were determined in adrenal glands, sympathetic ganglia and plasma of prehypertensive (4-week-old) and hypertensive (24-week-old) SHR. Vascular sympathetic innervation was visualized in the femoral artery by glyoxylic acid. Read More

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http://dx.doi.org/10.1038/s41440-018-0198-yDOI Listing
January 2019

Endocrinological Disorders Related to the Medical Use of Lithium. A Narrative Review.

Rev Colomb Psiquiatr 2019 Jan - Mar;48(1):35-43. Epub 2017 Feb 22.

Hospital Psiquiátrico de Tampico, Secretaría de Salud, Tamaulipas, México.

The prescribing of Lithium is common in psychiatric clinical practice. The aim of this study was to identify the most common endocrine side effects associated with this drug and to clarify the pathophysiological basis. A systematic review was conducted in Psycinfo, Embase, PubMed, and Scopus. Read More

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http://dx.doi.org/10.1016/j.rcp.2017.01.003DOI Listing
February 2017
1 Read

Pernicious anemia and endocrine glands antibodies.

Endokrynol Pol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Introduction: The aim of the study was to determine the frequency of occurrence of antibodies participating in the development of endocrine diseases in patients with autoimmune hematopoietic disease, thus documenting the potential suitability of specific diagnostic and screening tests.

Material And Methods: The study group consisted of 124 persons (men and women) with newly diagnosed Pernicious Anemia (PA) and the control group (C) of 41 healthy people. Antibodies against: internal factor (IFAb), gastric parietal cells (APCA), thyroid peroxidase (TPOAb), thyroglobulin (TgAb), adrenal cortex (AdrenalAb) and pituitary anterior lobe (PituitaryAb) were determined in the blood. Read More

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http://dx.doi.org/10.5603/EP.a2018.0086DOI Listing
January 2019

Protective Role of SOCS3 Modified Bone Marrow Mesenchymal Stem Cells in Hypoxia-Induced Injury of PC12 Cells.

J Mol Neurosci 2019 Jan 15. Epub 2019 Jan 15.

Department of Infection, Linyi Central Hospital, Linyi, 276400, Shandong, China.

We attempted to explore the possible effects of SOCS3 (suppressor of cytokine signaling 3)-modified bone marrow mesenchymal stem cells (BMSCs) on the hypoxic injury of rat adrenal gland pheochromocytoma (PC-12) cells. PC12 cells were cultured with EGFP (enhanced green fluorescent protein)-BMSCs and SOCS3-BMSCs respectively under hypoxia in vitro and classified into control, hypoxia, EGFP-BMSCs, and SOCS3-BMSC groups. CCK-8, Hoechst 33258 staining, and Annexin V-FITC/PI staining were assessed to measure the viability and apoptosis of hypoxia-induced PC12 cells. Read More

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http://dx.doi.org/10.1007/s12031-018-1243-7DOI Listing
January 2019

Survival outcomes following adrenalectomy for isolated metastases to the adrenal gland.

Eur J Surg Oncol 2019 Jan 4. Epub 2019 Jan 4.

Department of General Surgery, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, G51 4TF, United Kingdom.

Background: Adrenal metastases can arise from different primary sites. Surgical resection of the adrenal gland in patients with isolated metastases may offer improved survival in many of these patients. However, the benefit of surgery in this heterogenous group is often disputed. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.006DOI Listing
January 2019
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Isolation stress impacts Met-enkephalin in the hypothalamo-pituitary-adrenocortical axis in growing Polish Mountain sheep: a possible role of the opioids in modulation of HPA axis.

Stress 2019 Jan 14:1-9. Epub 2019 Jan 14.

c Center of Excellence in Poultry Science, University of Arkansas , Fayetteville , AR , USA.

It was hypothesized that there is cross-talk between the classical constituents of the hypothalamo-pituitary-adrenocortical axis (HPA) and Met-enkephalin in the HPA axis. The study examined effects of isolation stress, sex, and age on concentrations of native Met-enkephalin and pro-enkephalin (PENK) gene expression in tissues of the HPA (hypothalamus, pituitary gland and adrenal cortex) in 3-, 6- and 9-month old female and male lambs. In addition, the effects of isolation stress on in vitro release Met-enkephalin from fragments of the hypothalamus or adrenal cortex were examined. Read More

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http://dx.doi.org/10.1080/10253890.2018.1553947DOI Listing
January 2019

A Case of Stage IV Chromophobe Renal Cell Carcinoma Treated with the Oncolytic ECHO-7 Virus, Rigvir®.

Am J Case Rep 2019 Jan 12;20:48-52. Epub 2019 Jan 12.

International Virotherapy Center, Research and Development, Riga, Latvia.

BACKGROUND Renal cell carcinoma is the most commonly diagnosed primary malignant tumor of the kidney in adults, and includes the variant of chromophobe renal cell carcinoma. Despite new targeted therapies that improve progression-free survival (PFS) and overall survival (OS) for early-stage renal cell carcinoma, the 5-year survival for patients with stage IV renal cell carcinoma remains below 10%, and the 50% OS is less than one year. Metastatic renal cell carcinoma can be resistant to cytotoxic chemotherapy. Read More

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http://dx.doi.org/10.12659/AJCR.912115DOI Listing
January 2019
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Estrogen receptor profiles across tissues from male and female Rattus norvegicus.

Biol Sex Differ 2019 Jan 11;10(1). Epub 2019 Jan 11.

Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.

Background: Estrogen is formed by the enzyme aromatase (CYP19A1) and signals via three identified receptors ERα (ESR1), ERß (ESR2), and the G protein-coupled estrogen receptor (GPER). Understanding the relative contribution of each receptor to estrogenic signaling may elucidate the disparate effects of this sex hormone across tissues, and recent developments in PCR technology allow absolute quantification and direct comparison of multiple targets. We hypothesized that this approach would reveal tissue- and sex-specific differences in estrogen receptor mRNA. Read More

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https://bsd.biomedcentral.com/articles/10.1186/s13293-019-02
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http://dx.doi.org/10.1186/s13293-019-0219-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329134PMC
January 2019
3 Reads

Impaired chromaffin cells excitability and exocytosis in autistic Timothy syndrome TS2-neo mouse rescued by L-type calcium channel blockers.

J Physiol 2019 Jan 10. Epub 2019 Jan 10.

Dept. of Drug Science, N.I.S. Centre, University of Torino, Italy.

Key Points Summary: Tymothy syndrome (TS) is a multisystem disorder featuring cardiac arrhythmias, autism and adrenal gland dysfunction that originates from a de-novo point-mutation in the gene encoding Cav1.2 (CACNA1C) L-type channel. To study the role of Cav1. Read More

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http://dx.doi.org/10.1113/JP277487DOI Listing
January 2019
1 Read

Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil.

PLoS One 2019 10;14(1):e0209491. Epub 2019 Jan 10.

Centro de Medicina Tropical, Universidade de Brasília, Brasília, Distrito Federal, Brazil.

There is evidence that in southern US, leprosy is a zoonosis infecting wild Dasypus novemcinctus armadillos but the extent of this finding is unknown. This ecological study investigated leprosy in rural communities and in wild armadillos from the Brazilian Amazon. The study area was the Mamiá Lake of Coari municipality, Amazonas State, Northern region, a hyper endemic leprosy area where residents live on subsistence farming, fishing and armadillo hunting and its meat intake are frequent. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209491PLOS
January 2019
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Knowledge-aided Convolutional Neural Network for Small Organ Segmentation.

IEEE J Biomed Health Inform 2019 Jan 9. Epub 2019 Jan 9.

Accurate and automatic organ segmentation is critical for computer-aided analysis towards clinical decision support and treatment planning. State-of-the-art approaches have achieved remarkable segmentation accuracy on large organs such as the liver and kidneys. However, most of these methods do not perform well on small organs such as the pancreas, gallbladder and adrenal glands, especially when lacking sufficient training data. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2891526DOI Listing
January 2019

Wheel access has opposing effects on stress physiology depending on social environment in female prairie voles (Microtus ochrogaster).

Stress 2019 Jan 10:1-11. Epub 2019 Jan 10.

b Department of Psychology , Northern Illinois University , DeKalb , IL , USA.

Physical exercise and chronic social stress are both known to impact general health and hypothalamic-pituitary-adrenal (HPA) axis function, albeit typically in opposing directions. Therefore, the question we investigated in this study was how these two factors - physical exercise and chronic social isolation - would interact when presented simultaneously in a female rodent model. Adult female prairie voles were separated into four experimental groups: (1) isolated without wheel access, (2) isolated with wheel access, (3) paired without wheel access, and (4) paired with wheel access. Read More

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http://dx.doi.org/10.1080/10253890.2018.1553948DOI Listing
January 2019

Exposure to cell phone radiofrequency changes corticotrophin hormone levels and histology of the brain and adrenal glands in male Wistar rat.

Iran J Basic Med Sci 2018 Dec;21(12):1269-1274

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Objectives: Nowadays, the electromagnetic field-emitting devices are used routinely in our lives. Controversial reports exist concerning the effects of mobile radiofrequency (RF) on different parts of the body, especially stress hormones. The main goal of the present work was to study the long-term effects of mobile RF900 MHz exposure with special focus on the adrenal gland pathophysiology and function. Read More

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http://ijbms.mums.ac.ir/article_11712.html
Publisher Site
http://dx.doi.org/10.22038/ijbms.2018.29567.7133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312682PMC
December 2018
2 Reads

Postmenopausal androgen-secreting ovarian tumors: challenging differential diagnosis in two cases.

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

d Department of Internal Medicine (South), Faculty of Medicine , Universidad de Chile , Santiago , Chile.

Postmenopausal hyperandrogenism constitutes a very rare condition of tumoral or non-tumoral origin primarily residing either in the ovary or in the adrenal glands. We present herein two cases with this condition; one with abnormal postmenopausal genital bleeding and mild increase in facial hair, and the second with slow-developing hirsutism and virilization. Both cases shared a notorious increase in libido. Read More

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http://dx.doi.org/10.1080/13697137.2018.1549214DOI Listing
January 2019

Case Report of an Adrenocortical Carcinoma Associated With Germline Mutation.

J Endocr Soc 2019 Jan 12;3(1):284-290. Epub 2018 Dec 12.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Clinical Center, National Institutes of Health, Bethesda, Maryland.

Adrenocortical carcinoma (ACC) is an aggressive form of cancer that originates in the cortex of the adrenal gland; the incidence of ACC is 1.5 to 2 cases per million people per year. ACCs are rare and mostly sporadic. Read More

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https://academic.oup.com/jes/article/3/1/284/5239842
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http://dx.doi.org/10.1210/js.2018-00343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320243PMC
January 2019
2 Reads

MicroRNA351 targeting alleviates dexamethasone-induced myotube atrophy.

J Thorac Dis 2018 Nov;10(11):6238-6246

School of Biology and Basic Medical Sciences, Medical College of Soochow University, Suzhou 215123, China.

Background: Glucocorticoids, including dexamethasone (Dex), are corticosteroids secreted by the adrenal gland, which are used as potent anti-inflammatory, anti-shock, and immunosuppressive agents. Dex is commonly used in patients with malignant tumors, such lung cancer. However, administration of high-dose Dex induces severe atrophy of the skeletal muscle, and the underlying mechanisms of this skeletal muscle atrophy remain unclear. Read More

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http://jtd.amegroups.com/article/view/24923/19103
Publisher Site
http://dx.doi.org/10.21037/jtd.2018.10.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297431PMC
November 2018
2 Reads

Adrenal gland disorders, active component, U.S. Armed Forces, 2002-2017.

MSMR 2018 Dec;25(12):10-19

During 2002-2017, the most common incident adrenal gland disorder among male and female service members was adrenal insufficiency and the least common was adrenomedullary hyperfunction. Adrenal insufficiency was diagnosed among 267 females (crude overall incidence rate: 8.2 cases per 100,000 person-years [p-yrs]) and 729 males (3. Read More

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December 2018
1 Read

Feasibility and experience of the MinImAL procedure: Minimally Invasive perinatal and paediatric Autopsies with Laparoscopically assisted tissue sampling.

Ultrasound Obstet Gynecol 2019 Jan 8. Epub 2019 Jan 8.

Department of Histopathology, Great Ormond Street Hospital for Children, London, UK.

Objectives: Less invasive autopsy techniques have good acceptability to parents, but the published sampling adequacy of needle biopsy studies is generally poor. Minimally Invasive Autopsy with Laparoscopic assisted sampling (MinImAL) has the potential to increase the diagnostic yield of less invasive autopsy by improving the quality and quantity of tissue samples obtained, whilst concomitantly permitting visualisation, extraction and examination of internal organs through a small incision. We present the findings of the MinImAL procedure in a cohort of 103 unselected perinatal and paediatric cases performed at a tertiary referral centre over five years. Read More

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http://dx.doi.org/10.1002/uog.20211DOI Listing
January 2019

Hyperglycemia Induced by Chronic Restraint Stress in Mice Is Associated With Nucleus Tractus Solitarius Injury and Not Just the Direct Effect of Glucocorticoids.

Front Neurosci 2018 19;12:983. Epub 2018 Dec 19.

Department of Histology, Embryology and Neurobiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China.

Chronic restraint stress (CRS) can affect hypothalamic-pituitary-adrenal (HPA) axis activity and increase glucocorticoid levels. Glucocorticoids are stress hormones that regulate multiple aspects of energy homeostasis. Stress also impairs glucose tolerance. Read More

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http://dx.doi.org/10.3389/fnins.2018.00983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305899PMC
December 2018

The effects of cannabinoids on the endocrine system.

Endokrynol Pol 2018 ;69(6):705-719

Chair and Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland.

Cannabinoids are the derivatives of the cannabis plant, the most potent bioactive component of which is tetrahydrocannabinol (THC). The most commonly used drugs containing cannabinoids are marijuana, hashish, and hashish oil. These compounds exert their effects via interaction with the cannabinoid receptors CB1 and CB2. Read More

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http://dx.doi.org/10.5603/EP.a2018.0072DOI Listing
January 2018

Infradian Rhythms of Resistance to a Dissociative Anesthetic in Wistar Male Rats under Normal Conditions and After Surgical Removal of the Adrenal Glands and Testes.

Bull Exp Biol Med 2019 Jan 8. Epub 2019 Jan 8.

Research Institute of Human Morphology, Moscow, Russia.

Daily dynamics of changes in the latency of a response to dissociative anesthetic tiletamine (time from injection to ataxia) was studied in mature Wistar rats. Both intramuscular and intravenous administration of the anesthetic was associated with 4-day oscillations of the latent period synchronous with the dynamics of changes in the concentration of glucocorticoid hormones. The period and phases of the infradian rhythm of resistance to the anesthetic remained unchanged after removal of both adrenal glands and testes and administration of corticosterone synthesis blocker trilostane diminishing the 4-day cycle of changes in corticosterone level. Read More

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http://dx.doi.org/10.1007/s10517-019-04362-xDOI Listing
January 2019

Chronic and acute stress monitoring by electrophysiological signals from adrenal gland.

Proc Natl Acad Sci U S A 2019 Jan 7. Epub 2019 Jan 7.

Department of Biomedical Engineering, Sungkyunkwan University (SKKU), 16419 Suwon, Korea;

We present electrophysiological (EP) signals correlated with cellular cell activities in the adrenal cortex and medulla using an adrenal gland implantable flexible EP probe. With such a probe, we could observe the EP signals from the adrenal cortex and medulla in response to various stress stimuli, such as enhanced hormone activity with adrenocorticotropic hormone, a biomarker for chronic stress response, and an actual stress environment, like a forced swimming test. This technique could be useful to continuously monitor the elevation of cortisol level, a useful indicator of chronic stress that potentially causes various diseases. Read More

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http://dx.doi.org/10.1073/pnas.1806392115DOI Listing
January 2019

Correlation Between Physiologic and Osteopathic Measures of Sympathetic Activity in Women With Polycystic Ovary Syndrome.

J Am Osteopath Assoc 2019 Jan;119(1):7-17

Background: Polycystic ovary syndrome (PCOS) is a common hormone disorder that affects the reproductive, metabolic, and psychological health of reproductive-aged females, with a number of long-term health risks, including type 2 diabetes mellitus and cardiovascular sequelae. Sympathetic hyperactivity in affected persons may be involved in the pathogenesis of the disorder.

Objective: To determine whether physiologic and osteopathic measures of increased sympathetic tone correlate in a population of women with PCOS. Read More

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http://dx.doi.org/10.7556/jaoa.2019.004DOI Listing
January 2019
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Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats.

Environ Sci Pollut Res Int 2019 Jan 6. Epub 2019 Jan 6.

Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria.

This study investigated the role of melatonin (MLT) on adrenal gland toxicity induced by bisphenol A (BPA). Adult male rats were divided into four groups of seven animals each: Group I (control) received oral 0.2 ml canola oil; group II received intra-peritoneal 10 mg/kg BW/day MLT; and group III received oral BPA (10 mg/kg BW/day). Read More

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http://dx.doi.org/10.1007/s11356-018-4024-5DOI Listing
January 2019
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Pheochromocytoma presenting with severe hyperglycemia and metabolic acidosis following intra-articular glucocorticoid administration: a case report.

J Med Case Rep 2019 Jan 5;13(1). Epub 2019 Jan 5.

Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.

Background: There are several reports of pheochromocytoma crisis triggered by systemic glucocorticoid administration. However, pheochromocytoma crisis after intra-articular glucocorticoid administration has been rarely reported.

Case Presentation: A 45-year-old Japanese man presented to our hospital with a sudden, severe headache. Read More

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http://dx.doi.org/10.1186/s13256-018-1945-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320610PMC
January 2019
1 Read

Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.

Int J Mol Sci 2019 Jan 3;20(1). Epub 2019 Jan 3.

Department of Pharmacology and Toxicology, Veterinary Faculty, Universidad Complutense de Madrid, 28040 Madrid, Spain.

We have tested the hypothesis that neuropathic pain acting as a stressor drives functional plasticity in the sympathoadrenal system. The relation between neuropathic pain and adrenal medulla function was studied with behavioral, immunohistochemical and electrophysiological techniques in rats subjected to chronic constriction injury of the sciatic nerve. In slices of the adrenal gland from neuropathic animals, we have evidenced increased cholinergic innervation and spontaneous synaptic activity at the splanchnic nerve⁻chromaffin cell junction. Read More

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http://www.mdpi.com/1422-0067/20/1/155
Publisher Site
http://dx.doi.org/10.3390/ijms20010155DOI Listing
January 2019
1 Read

Tissue Distribution of Menaquinone-7 and the Effect of α-Tocopherol Intake on Menaquinone-7 Concentration in Rats.

J Nutr Sci Vitaminol (Tokyo) 2018 ;64(6):391-398

Department of Home Economics, Aichi Gakusen University.

We have reported that vitamin E intake lowers phylloquinone (PK) concentration in extrahepatic tissues of rats. In this study, we aimed to clarify the characteristic of the distribution of menaquinone-7 (MK-7), a vitamin K contained in fermented foods, by comparison with other vitamin K distributions and to clarify the effect of vitamin E intake on MK-7 concentration in rats. Rats were fed a vitamin K-free diet (Free group), a diet containing 0. Read More

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http://dx.doi.org/10.3177/jnsv.64.391DOI Listing
January 2018

Management of blunt adrenal gland injury in a community-based hospital.

Injury 2018 Dec 28. Epub 2018 Dec 28.

Department of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates.

Introduction: Injury of the adrenal gland in blunt trauma is rare. The routine usage of the whole body computed tomography (CT) scan helps in early diagnosis. We aimed to study the incidence, mechanism of injury, management, and outcome of adrenal injury in blunt trauma patients treated in a community-based hospital. Read More

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http://dx.doi.org/10.1016/j.injury.2018.12.033DOI Listing
December 2018
1 Read

Immune evasion-related extranodal large B-cell lymphoma: A report of six patients with neoplastic PD-L1-positive extranodal diffuse large B-cell lymphoma.

Pathol Int 2019 Jan 2. Epub 2019 Jan 2.

Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.

We identified six patients with Epstein-Barr virus (EBV)-negative extranodal diffuse large B-cell lymphoma (DLBCL) and immunohistochemical expression of PD-L1 on their tumor cells by examining 283 DLBCL cases with the PD-L1 SP142 clone between 2015 and 2017. They consisted of two men and four women with a median age of 71 years, and were examined in an autopsy (n = 1) and biopsies from the adrenal gland (n = 2), skin (n = 1), pelvic cavity (n = 1), and kidney (n = 1). All showed a monomorphic population of large transformed B-cells leading to diagnoses of DLBCL with two intravascular large B-cell lymphoma (IVLBCL) and one de novo CD5+ type and were featured by an invariable immunephenotype: CD3-, CD20+, BCL-2+, and MUM1+. Read More

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http://dx.doi.org/10.1111/pin.12742DOI Listing
January 2019
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Pheochromocytoma in Dogs Undergoing Adrenalectomy.

Vet Pathol 2018 Dec 30:300985818819174. Epub 2018 Dec 30.

7 Department of Comparative Biomedicine and Food Sciences, University of Padova, Legnaro PD, Italy.

Pheochromocytoma is frequent in dogs and carries a guarded prognosis. Current histological criteria may not predict malignant behavior in dogs, similar to humans. In humans, characterization of tumors has been refined using the pheochromocytoma of the adrenal gland scaled score (PASS) and by immunohistochemistry. Read More

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http://dx.doi.org/10.1177/0300985818819174DOI Listing
December 2018
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Transperitoneal versus retroperitoneal laparoscopic adrenalectomy for adrenal tumours in adults.

Cochrane Database Syst Rev 2018 12 30;12:CD011668. Epub 2018 Dec 30.

Department of Surgical Sciences, University of Torino, Corso Achille Mario Dogliotti 14, Turin, Italy, 10126.

Background: Laparoscopic adrenalectomy is an accepted treatment worldwide for adrenal gland disease in adults. The transperitoneal approach is more common. The retroperitoneal approach may be preferred, to avoid entering the peritoneum, but no clear advantage has been demonstrated so far. Read More

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http://dx.doi.org/10.1002/14651858.CD011668.pub2DOI Listing
December 2018

CCCH-type zinc finger antiviral protein is specifically overexpressed in spleen in response to subgroup J avian leukosis virus infection in chicken.

Res Vet Sci 2018 Dec 23;123:65-70. Epub 2018 Dec 23.

College of Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China. Electronic address:

The CCCH-type zinc finger antiviral protein (ZAP), a host antiviral factor, plays an important role in innate defenses. Although the anti-viral mechanism of ZAP has been elucidated, however, the tissue specificity and the viral infection correlativity have not been fully understood. Here, we tested the dynamic distribution and localization of chicken ZAP (chZAP) before and after avian leukosis virus subgroup J (ALV-J) infection. Read More

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http://dx.doi.org/10.1016/j.rvsc.2018.12.017DOI Listing
December 2018

COMPARISON OF TRANSCUTANEOUS ULTRASOUND AND COMPUTED TOMOGRAPHY EVALUATION OF KIDNEY SIZE AND EVALUATION OF ADRENAL GLAND SIZE USING ULTRASOUND IN A COLONY OF CALLIMICOS ( CALLIMICO GOELDII).

J Zoo Wildl Med 2018 Dec;49(4):887-892

Both kidney and adrenal gland disease have been identified in callimicos ( Callimico goeldii). Ultrasonography (US) and computed tomography (CT) are routinely utilized in veterinary patients with suspected renal or adrenal disease to determine size, shape, and echogenicity of these organs. No previous US and CT kidney and adrenal gland measurements have been published for callimicos. Read More

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http://dx.doi.org/10.1638/2017-0078.1DOI Listing
December 2018

Laparoscopic adrenalectomy for metastatic disease: Retrospective cohort with long-term, comprehensive follow-up.

Surgery 2018 Dec 24. Epub 2018 Dec 24.

Division of Endocrine Surgery, Department of Surgery, University of California, San Francisco, CA.

Background: Several malignancies metastasize to the adrenal gland, especially non-small cell lung cancer, renal cell carcinoma, and melanoma. Adrenalectomy is associated with prolonged survival, but laparoscopic adrenalectomy for this indication is controversial. Our objective was to characterize and quantify outcomes after laparoscopic adrenalectomy for metastases to the adrenal gland. Read More

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http://dx.doi.org/10.1016/j.surg.2018.11.008DOI Listing
December 2018
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Characterization of Human Adrenal Steroidogenesis during Fetal Development.

J Clin Endocrinol Metab 2018 Dec 21. Epub 2018 Dec 21.

Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark.

Context: The endocrine function of human fetal adrenals (HFA) is activated already during first trimester, but changes in adrenal steroidogenesis during fetal life are not well characterized.

Objective: This study aimed to investigate HFA steroidogenesis by analyzing adrenal glands from 1st and 2nd trimester.

Design And Setting: Male and female HFA samples from gestational week (GW) 8-19 were examined, including a total of 101 samples from 83 fetuses. Read More

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http://dx.doi.org/10.1210/jc.2018-01759DOI Listing
December 2018

De Novo Testicular Extranodal NK/T-Cell Lymphoma: A Clinicopathologic Study of 21 Cases With Review of Additional 18 Cases in the Literature.

Am J Surg Pathol 2018 Dec 26. Epub 2018 Dec 26.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.

Although the testis is not uncommonly involved during the course of disease in both nasal and non-nasal extranodal NK/T-cell lymphoma (ENKTCL), only a few cases presenting initially with a testicular mass have been previously reported. These have been documented as case reports, rather than as study series. Because of its rarity, the clinicopathologic features and the prognosis of de novo testicular ENKTCL have not been well characterized. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001210DOI Listing
December 2018
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Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats.

J Vet Med Sci 2018 Dec 27. Epub 2018 Dec 27.

United Graduate School of Veterinarian Sciences, Gifu University.

The influence of different levels of heat exposure on the functions of ovarian and adrenal gland were investigated in pre-puberty female rats. Three-week old female rats were treated with control (26℃) or three higher temperatures (38, 40 and 42℃) for 2hr/day. After 9 days of treatment, blood samples were collected for measurement of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol-17β, corticosterone, cholesterol and triglyceride. Read More

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https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_18
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http://dx.doi.org/10.1292/jvms.18-0644DOI Listing
December 2018
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Melatonin prevents early pituitary dysfunction induced by sucrose-rich diets.

J Pineal Res 2018 Dec 26:e12545. Epub 2018 Dec 26.

Facultad de Medicina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Universidad de Buenos Aires, Buenos Aires, Argentina.

While physiological levels of glucocorticoids are required to ensure proper functions of the body, consistently high levels may engender several deleterious consequences. We have previously shown an increase in the activity of the hypothalamic-pituitary-adrenal (HPA) axis in rats fed sucrose-rich diets (SRD). The main goal of this study was to analyze the processes involved in the modulation of the pituitary production of ACTH by SRD, and to test melatonin as a possible therapeutic agent for the prevention of the HPA axis dysfunction. Read More

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http://dx.doi.org/10.1111/jpi.12545DOI Listing
December 2018

Sclerosing Kaposi's sarcoma of the adrenal gland in an HIV-infected patient under antiretroviral therapy.

Ann Diagn Pathol 2018 Dec 14;38:123-125. Epub 2018 Dec 14.

Department of Pathology, Hospital Clínic de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.003DOI Listing
December 2018

The pituitary gland prevents shock-associated death by controlling multiple inflammatory mediators.

Biochem Biophys Res Commun 2019 Jan 20;509(1):188-193. Epub 2018 Dec 20.

Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. Electronic address:

Bacterial infections cause a major burden of disease worldwide. Sepsis and septic shock are life-threatening complications of infections. The hypothalamic-pituitary-adrenal (HPA) axis initiates the release of endogenous glucocorticoids that modulate the host stress response and acute inflammation during septic shock. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183275
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http://dx.doi.org/10.1016/j.bbrc.2018.12.101DOI Listing
January 2019
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Development of [F]FAMTO: A novel fluorine-18 labelled positron emission tomography (PET) radiotracer for imaging CYP11B1 and CYP11B2 enzymes in adrenal glands.

Nucl Med Biol 2018 Nov 9. Epub 2018 Nov 9.

School of Imaging Sciences & Biomedical Engineering, 4th floor Lambeth Wing, St Thomas' Hospital, King's College London, London SE1 7EH, United Kingdom. Electronic address:

Introduction: Primary aldosteronism accounts for 6-15% of hypertension cases, the single biggest contributor to global morbidity and mortality. Whilst ~50% of these patients have unilateral aldosterone-producing adenomas, only a minority of these have curative surgery as the current diagnosis of unilateral disease is poor. Carbon-11 radiolabelled metomidate ([C]MTO) is a positron emission tomography (PET) radiotracer able to selectively identify CYP11B1/2 expressing adrenocortical lesions of the adrenal gland. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.11.002DOI Listing
November 2018