104,285 results match your criteria Adrenal Gland


Clinical Diagnosis of Classical Cornelia de Lange Syndrome Made From Postmortem Examination of Second Trimester Fetus With Novel NIPBL Pathogenic Variant.

Pediatr Dev Pathol 2019 Mar 19:1093526619834429. Epub 2019 Mar 19.

1 Department of Clinical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Classical Cornelia de Lange syndrome (CdLS) is a rare genetic disorder which is associated with distinctive facial features, growth retardation, significant intellectual disability and global developmental delay, hirsutism, and upper-limb reduction defects. Classical CdLS is associated with pathogenic variants in NIPBL. We present a clinical diagnosis of classical CdLS made in a second trimester male fetus with advanced maceration who had undergone intrauterine death at 15 + 6 weeks gestation. Read More

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http://dx.doi.org/10.1177/1093526619834429DOI Listing

Multiorgan toxicity induced by EtOH extract of Fructus Psoraleae in Wistar rats.

Phytomedicine 2019 Feb 25;58:152874. Epub 2019 Feb 25.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, PR China. Electronic address:

Background: The fruits of Psoralea corylifolia L. (Fructus Psoraleae, FP) has a long history and a wide range of applications in the treatment of osteoporosis and leukoderma. Although it is well known that FP could cause hepatotoxicity and reproductive toxicity, less is known about its potential toxicity on multiple organs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113193004
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http://dx.doi.org/10.1016/j.phymed.2019.152874DOI Listing
February 2019
1 Read

Malignant Peripheral Nerve Sheath Tumor With Bilateral Adrenal Metastases: Role of 18F-FDG PET/CT in Response Assessment to Tyrosine Kinase Inhibitor and Liposomal Doxorubicin.

Clin Nucl Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Nuclear Medicine and PET-CT, Institute of Liver and Biliary Sciences, New Delhi, India.

MPNSTs (malignant peripheral nerve sheath tumors) are a highly malignant group of soft tissue sarcomas and carry a very poor prognosis. Metastasis to bilateral adrenal glands is very rare in such group of neoplasms. We discuss a case of 85-year-old man who was diagnosed with MPNST from prevertebral mass with metastases to bilateral adrenal glands and bone marrow from the beginning and role of serial F-FDG PET/CT scans in response assessment first to sunitinib (tyrosine kinase inhibitor) and then to liposomal doxorubicin. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002542DOI Listing

Factitious Cushing's Syndrome: A Diagnosis to Consider When Evaluating Hypercortisolism.

Front Endocrinol (Lausanne) 2019 4;10:129. Epub 2019 Mar 4.

Clínica Quirúrgica 1, Facultad de Medicina, Hospital Pasteur, Universidad de la República, Montevideo, Uruguay.

Factitious Cushing's syndrome is exceptionally rare. The diagnosis is challenging due to the interference of exogenous corticosteroids with cortisol immunoassays. We present a case of a 26 year old female that presented with clinical and biochemical features of Cushing's syndrome. Read More

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http://dx.doi.org/10.3389/fendo.2019.00129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409302PMC

Primary adrenal extranasal NK/T cell lymphoma with subcutaneous involvement demonstrated on FDG PET/CT: A clinical case report.

Medicine (Baltimore) 2019 Mar;98(11):e14818

Department of Nuclear Medicine.

Rationale: Primary adrenal non-Hodgkin lymphomas are predominant diffuse large B cell lymphoma with frequently bilateral adrenal involvement, but the occurrence of nasal type extranodal NK/T cell lymphoma is relatively rare.

Patient Concerns: A 40-year-old woman complaining of left back pain for 2-month was admitted to our department.

Diagnosis: Based on the feature of enhanced computed tomography (CT) images which showed huge bilateral well-defined adrenal masses with heterogeneous enhancement, she was tentatively diagnosed as having primary adrenal malignancy. Read More

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http://Insights.ovid.com/crossref?an=00005792-201903150-0004
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http://dx.doi.org/10.1097/MD.0000000000014818DOI Listing
March 2019
1 Read

An enlarged left adrenal gland is an indirect sign of infection on 18F-FDG PET/CT.

Nucl Med Commun 2019 Mar 14. Epub 2019 Mar 14.

Nuclear Medicine and Nancyclotep Experimental Platform.

Objectives: To determine whether hypermetabolisms of the spleen and bone marrow and an enlarged adrenal gland are significant indirect signs of infection on fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT performed in patients with known or suspected infectious disease.

Patients And Methods: Potential indirect signs of infection were as follows: (i) investigated in a retrospectively selected group of patients referred to F-FDG PET/CT for a known or suspected infectious disease and among whom the presence or absence of infectious foci was ascertained in 43 and 12 cases, respectively, and (ii) further validated in groups prospectively constituted of 12 patients with severe sepsis and of 39 control patients with no sign of any infectious disease. Standardised uptake values were determined on left adrenal gland, spleen and bone marrow, whereas the size of left adrenal gland was assessed by its maximal surface on unenhanced axial computed tomography (CT) slices. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001013DOI Listing

Calcium Imaging Reveals That Cortisol Treatment Reduces the Number of Place Cells in Thy1-GCaMP6f Transgenic Mice.

Front Neurosci 2019 1;13:176. Epub 2019 Mar 1.

Janssen Research & Development, LLC., San Diego, CA, United States.

The hippocampus, a structure essential for spatial navigation and memory undergoes anatomical and functional changes during chronic stress. Here, we investigate the effects of chronic stress on the ability of place cells to encode the neural representation of a linear track. To model physiological conditions of chronic stress on hippocampal function, transgenic mice expressing the genetically encoded calcium indicator GCaMP6f in CA1 pyramidal neurons were chronically administered with 40 μg/ml of cortisol for 8 weeks. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2019.00176
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http://dx.doi.org/10.3389/fnins.2019.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405689PMC
March 2019
1 Read

Retention of aberrant cortisol secretion in a patient with bilateral macronodular adrenal hyperplasia after unilateral adrenalectomy.

Ther Clin Risk Manag 2019 27;15:337-342. Epub 2019 Feb 27.

Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan,

Aberrant cortisol secretion responses after exogenous stimuli such as upright posture, eating a mixed meal or receiving agents influencing aberrant G-protein-coupled receptors in adrenal glands, are often observed in patients with bilateral macronodular adrenal hyperplasia (BMAH). However, little is known about whether this aberrant response is retained after unilateral adrenalectomy. Here, we describe a 61-year-old postmenopausal Japanese woman with unsatisfactorily controlled hypertension who was referred to us for further investigation due to her pre-obesity characteristics (body mass index 28. Read More

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http://dx.doi.org/10.2147/TCRM.S196171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398404PMC
February 2019

Performance characteristics of EUS-FNA biopsy for adrenal lesions: A meta-analysis.

Endosc Ultrasound 2019 Mar 12. Epub 2019 Mar 12.

Indiana University School of Medicine, Indianapolis, IN, USA.

Background And Objective: The role of EUS-FNA biopsy (EUS-FNAB) for detection of metastatic lesions (mets) to adrenals has not been evaluated systematically. Our aim is to systematically evaluate the performance characteristics of EUS-FNAB in detecting metastasis to the adrenal glands.

Materials And Methods: We performed a systematic search on PubMed and OvidSP from January 1990 to July 2016 using various search terms for EUS and adrenal lesion. Read More

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http://dx.doi.org/10.4103/eus.eus_42_18DOI Listing

Effects of citrate ester plasticizers and bis (2-ethylhexyl) phthalate in the OECD 28-day repeated-dose toxicity test (OECD TG 407).

Environ Res 2019 Mar 8;172:675-683. Epub 2019 Mar 8.

Department of Life Science and Institute for Natural Sciences, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. Electronic address:

Citrate esters are considered functional alternatives to phthalate plasticizers, but their toxicity remains poorly understood. The toxicity of citrate esters, including triethyl 2-acetylcitrate (ATEC) and trihexyl O-acetylcitrate (ATHC), were examined together with that of bis (2-ethylhexyl) phthalate (DEHP) using the Organization for Economic Co-operation and Development Test Guideline 407 (OECD TG407). Following 28-day oral administration, no significant differences in body weight or the weight of the brain, pituitary, heart, epididymis, seminal vesicles, or coagulating gland were found between the vehicle control and DEHP, ATEC or ATHC groups. Read More

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http://dx.doi.org/10.1016/j.envres.2019.03.004DOI Listing

Angiomyolipoma of the Adrenal Glands.

Clin Genitourin Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Diagnostic Radiology, University of Illinois at Chicago, Chicago, IL. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2019.02.004DOI Listing
February 2019

Chronological Aging Standard Curves of Telomere Length and Mitochondrial DNA Copy Number in Twelve Tissues of C57BL/6 Male Mouse.

Cells 2019 Mar 15;8(3). Epub 2019 Mar 15.

Department of Anatomy and Convergence Medical Sciences, Gyeongsang National University School of Medicine, Jinju 52727, Korea.

The changes in telomere length and mitochondrial DNA copy number (mtDNAcn) are considered to be aging markers. However, many studies have provided contradictory or only fragmentary information about changes of these markers in animal models, due to inaccurate analysis methods and a lack of objective aging standards. To establish chronological aging standards for these two markers, we analyzed telomere length and mtDNAcn in 12 tissues-leukocytes, prefrontal cortex, hippocampus, pituitary gland, adrenal gland, retina, aorta, liver, kidney, spleen, skeletal muscle, and skin-from a commonly used rodent model, C57BL/6 male mice aged 2⁻24 months. Read More

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http://dx.doi.org/10.3390/cells8030247DOI Listing
March 2019
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Optimization of Extraction Technology of Majun Mupakhi Ela and its Effect on Hydrocortisone-induced Kidney Yang Deficiency in Mice.

Sci Rep 2019 Mar 15;9(1):4628. Epub 2019 Mar 15.

Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 830011, Urumqi, Xinjiang, China.

We used Box-Behnken design-based (BBD) response surface methodology (RSM) in this research to optimize the extraction process of Traditional medicine Majun Mupakhi Ela (MME) and evaluate its effect on hydrocortisone-induced kidney yang deficiency. Three independent parameters were applied to evaluate the maximum phosphodiesterase type 5 (PDE5) inhibition activity of MME extracts in vitro. The optimal processing conditions (extraction time 2 h, solid-liquid ratio 1:16, extraction once) gave a maximum PDE5 inhibition rate of 84. Read More

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http://dx.doi.org/10.1038/s41598-019-41006-6DOI Listing

Tuberculous Addison's disease with increased hydrocortisone requirements due to administration of rifampicin.

BMJ Case Rep 2019 Mar 14;12(3). Epub 2019 Mar 14.

Metabolism and Endocrinology, Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan.

A 58-year-old man was referred to our hospital for darkened skin, general fatigue and weight loss. His adrenocorticotropic hormone and cortisol levels indicated a primary adrenal insufficiency. Fluorodeoxyglucose positron emission tomography/CT showed bilateral enlargement of the adrenal glands, with fluorodeoxyglucose accumulation. Read More

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http://dx.doi.org/10.1136/bcr-2018-228293DOI Listing
March 2019
1 Read

Characteristics and relative numbers of lethal snake bite cases in medicolegal practice in central Myanmar - A five year study.

J Forensic Leg Med 2019 Apr 5;63:52-55. Epub 2019 Mar 5.

The University of Adelaide Medical School, Frome Road, Adelaide, SA, 5005, Australia; Forensic Science SA, 21 Divett Place, Adelaide, SA, 5000, Australia. Electronic address:

Clinical and pathological case files of lethal snakebites were reviewed from the XXXX, Magway, Myanmar, over a five-year period (January 2013 December 2017). A total of 2069 postmortem examinations were performed which included 84 cases of lethal snake bite (4.1%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1752928X183050
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http://dx.doi.org/10.1016/j.jflm.2019.03.005DOI Listing
April 2019
3 Reads

COPPS, a composite score integrating pathological features, PS100 and SDHB losses, predicts the risk of metastasis and progression-free survival in pheochromocytomas/paragangliomas.

Virchows Arch 2019 Mar 13. Epub 2019 Mar 13.

Department of Pathology, CHRU de Nancy, Université de Lorraine, F-54000, Nancy, France.

Current histoprognostic parameters and prognostic scores used in paragangliomas and pheochromocytomas do not adequately predict the risk of metastastic progression and survival. Here, using a series of 147 cases of paraganglioma and pheochromocytoma, we designed and evaluated the potential of a new score, the COPPS (COmposite Pheochromocytoma/paraganglioma Prognostic Score), by taking into consideration three clinico-pathological features (including tumor size, necrosis, and vascular invasion), and the losses of PS100 and SDHB immunostain to predict the risk of metastasis. We compared also the performance of the COPPS with several presently used histoprognostic parameters in risk assessment of these tumors. Read More

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http://dx.doi.org/10.1007/s00428-019-02553-5DOI Listing
March 2019
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PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy.

J Clin Endocrinol Metab 2019 Mar 13. Epub 2019 Mar 13.

Hypertension Unit, Department of Medicine -DIMED, University of Medicine of Padova, Padova, Italy.

Context: Accumulating evidences suggest a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored.

Objectives: To test the hypothesis that in vivo Angiotensin (Ang) II blockade affects parathyroid hormone (PTH) secretion in hypertensive patients and that aldosterone and Ang II directly stimulate PTH secretion ex vivo.

Design And Setting: We investigated the changes of serum PTH levels induced by oral captopril (50 mg) administration in patients with primary essential hypertension (EH) and with primary aldosteronism (PA) due to bilateral adrenal hyperplasia (BAH) or to aldosterone-producing adenoma (APA), the latter before and after adrenalectomy. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2019-00143DOI Listing
March 2019
3 Reads

Reference intervals for serum 17α-hydroxyprogesterone and ultrasonographic adrenal gland sizes in healthy newborns.

J Matern Fetal Neonatal Med 2019 Mar 13:1-11. Epub 2019 Mar 13.

a Karadeniz Teknik Universitesi Tip Fakultesi , Trabzon , Turkey.

Background And Objectives: Serum 17α- hydroxyprogesterone (17OHP) and bilateral adrenal sizes are pivotal for clinical practice in both diagnosis and treatment of congenital adrenal disorders during the first month of life. Our aims were to determine the reference ranges for serum 17OHP and bilateral adrenal gland sizes according to sex and age groups in healthy term newborns.

Materials And Methods: A total of 156 healthy newborns, aged 4-7 days (Group 1) or 26-30 days old (Group 2) were included in the study. Read More

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http://dx.doi.org/10.1080/14767058.2019.1594188DOI Listing

Repeated restraint stress upregulates rat sulfotransferase 1A1.

J Basic Clin Physiol Pharmacol 2018 Dec 20. Epub 2018 Dec 20.

Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74074, USA, Phone: +405-744-2349.

BackgroundSulfotransferases (SULTs) are phase II drug-metabolizing enzymes. SULTs also regulate the biological activities of biological signaling molecules, such as various hormones, bile acids, and monoamine neurotransmitters; therefore, they play critical roles in the endocrine and nervous systems. People are subject to various kinds of physical, chemical, toxicological, physiological, and psychological stresses at one time or another. Read More

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http://dx.doi.org/10.1515/jbcpp-2016-0038DOI Listing
December 2018

Effects of Intranasal Oxytocin on Pup Deprivation-Evoked Aberrant Maternal Behavior and Hypogalactia in Rat Dams and the Underlying Mechanisms.

Front Neurosci 2019 26;13:122. Epub 2019 Feb 26.

Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.

Oxytocin (OT), a hypothalamic neuropeptide, applied through nasal approach (IAO), could improve maternal health during lactation that is disrupted by mother-baby separation; however, the regulation of IAO effects on maternal behaviors and lactation as well as the underlying mechanisms remain unclear. Using lactating rats, we observed effects of intermittent pup deprivation (PD) with and without IAO on maternal behaviors and lactation as well as the activity of OT neurons in the supraoptic nucleus (SON) and the activity of hypothalamic pituitary-adrenal axis, key factors determining the milk-letdown reflex during lactation and maternal behaviors. The results showed that PD reduced maternal behaviors and lactation efficiency of rat dams as indicated by significantly longer latency to retrieve their pups and low litter's body weight gains during the observation, respectively. Read More

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http://dx.doi.org/10.3389/fnins.2019.00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399306PMC
February 2019

Cystic lymphangiomatous lesions of the adrenal gland: A clinicopathological study of 37 cases including previously unreported cysts with papillary endothelial proliferation.

Pathol Res Pract 2019 Mar 6. Epub 2019 Mar 6.

Department of Pathology, Medical University of Warsaw, ul. Pawińskiego 7, 02-142, Warsaw, Poland.

Published data regarding lymphangiomatous cysts of the adrenal glands (also known as adrenal cystic lymphangiomas) are limited to case reports and a few small case series. We analyzed the clinicopathologic features and histomorphologic spectrum of 37 cases of adrenal cystic lymphangiomatous lesions. There were 26 females and 11 males ranging from 12 to 67 years old (median, 34 years). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183182
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http://dx.doi.org/10.1016/j.prp.2019.03.014DOI Listing
March 2019
2 Reads

Targeting high transcriptional control activity of long mononucleotide A-T repeats in cancer by Argonaute 1.

Gene 2019 Mar 9;699:54-61. Epub 2019 Mar 9.

Center of Excellence in Molecular Genetic of Cancer and Human Disease, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand. Electronic address:

Epigenetic regulatory changes alter the gene regulation function of DNA repeat elements in cancer and consequently promote malignant phenotypes. Some short tandem repeat sequences, distributed throughout the human genome, can play a role as cis-regulatory elements of the genes. Distributions of tandem long (≥10) and short (<10) A-T repeats in the genome are different depending on gene functions. Read More

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http://dx.doi.org/10.1016/j.gene.2019.03.010DOI Listing
March 2019
2 Reads

Concomitant occurrence of primary renal non-Hodgkin lymphoma and a colon cancer: A rare case report.

Medicine (Baltimore) 2019 Mar;98(10):e14802

Department of Pathology.

Rationale: Primary renal lymphoma (PRL) is a rare malignancy due to the absence of lymphatic tissues in the kidney, and patients with PRL have been reported to have a poor prognosis due to its rapid invasiveness and limited treatment strategies. Colon cancer is the third most common cancer, and has a high mortality rate. Both malignant diseases predominantly affected elderly men; however, a case with concomitant occurrence of the 2 cancers is extremely rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000014802DOI Listing
March 2019
1 Read

Diabetes mellitus secondary to treatment with immune checkpoint inhibitors.

Curr Oncol 2019 Feb 1;26(1):e111-e114. Epub 2019 Feb 1.

First Department of Clinical Oncology, Theagenio Hospital, Thessaloniki, Greece.

Cancer immunotherapy has been one of the highlights in the advancement of cancer care. Certain immune checkpoint inhibitors bind to PD-1 on T cells and mediate an antitumour immune response. Given that immune checkpoint inhibitors are becoming part of standard care, a new class of adverse events-immune-related adverse events-has emerged. Read More

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http://dx.doi.org/10.3747/co.26.4151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380640PMC
February 2019
2 Reads

Laparoscopic subtotal pancreatectomy with radical antegrade modular pancreatosplenectomy for left-sided pancreatic cancer.

Surg Oncol 2019 Mar 3;28:150. Epub 2019 Jan 3.

Departments of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.

Background: Numerous recent studies have reported comparable oncologic outcomes of laparoscopic distal pancreatectomy for pancreatic cancer compared with open surgery [1,2]. Most of these laparoscopic procedures, however, involved resection for left-sided pancreatic cancer where R0 resection was possible by pancreatic transection around the portal vein-superior mesenteric vein with preservation of the gastroduodenal artery (GDA) [3,4]. Here we describe our technique of laparoscopic subtotal pancreatectomy for pancreatic cancer located in the neck of the pancreas, which requires resection of the GDA and radical antegrade modular pancreatosplenectomy (RAMPS) to achieve a clear resection margin. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.12.006DOI Listing
March 2019
2 Reads

Minimally Invasive Surgery for Primary and Metastatic Adrenal Malignancy.

Surg Oncol Clin N Am 2019 04 11;28(2):309-326. Epub 2019 Jan 11.

Department of Surgical Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Since the first description of laparoscopic adrenalectomy (LA) for pheochromocytoma and Cushing syndrome in 1992, the utilization of and indications for a minimally invasive approach to the adrenal gland have vastly expanded. Although minimally invasive adrenalectomy has been established as the preferred approach for patients with benign tumors of the adrenal gland, minimally invasive adrenalectomy for cancer remains controversial. In this article, the authors review the indications for minimally invasive adrenalectomy for adrenal nodules suspicious for, or established to represent, a primary malignancy or a site of metastatic cancer. Read More

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http://dx.doi.org/10.1016/j.soc.2018.11.011DOI Listing
April 2019
2 Reads

Effects of corticosterone on the expression of mature brain-derived neurotrophic factor (mBDNF) and proBDNF in the hippocampal dentate gyrus.

Behav Brain Res 2019 Mar 6;365:150-156. Epub 2019 Mar 6.

Department of Physiology, Shanxi Medical University, Taiyuan 030001, PR China.

Chronic stressor induces the release of glucocorticoid from the adrenal glands, the subsequent decrease of hippocampal volume, and the development of depression. Brain-derived neurotrophic factor (BDNF), composed of mature BDNF (mBDNF) and proBDNF, plays opposite roles in the structural integrity of the brain. However, the underlying mechanism of glucocorticoid-induced hippocampal atrophy remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.010DOI Listing
March 2019
1 Read

In-vitro pre-treatment of cancer cells with TGF-β1: A novel approach of Tail vein lung cancer metastasis mouse model for anti-metastatic studies.

Curr Mol Pharmacol 2019 Mar 6. Epub 2019 Mar 6.

Jiangsu key laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009. China.

Background: Aggressive behavior of tumor metastasis comes from certain mutations, changes in cellular metabolic and signaling pathways that are majorly altered by tumor microenvironment (TME), its other components and growth factors like transforming growth factor-β1 (TGF-β1) which is chiefly known for its epithelial to mesenchymal transformation (EMT). EMT is a critical step of metastasis cascade in actual human lung cancer scenario.

Objective: Our present study is focused to unveil the in-vivo metastatic behavior of TGF-β1 treated lung cancer cells that undergone EMT. Read More

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http://dx.doi.org/10.2174/1874467212666190306165703DOI Listing

Expression profile of Galp, alarin and their receptors in rat adrenal gland.

Adv Clin Exp Med 2019 Mar 6. Epub 2019 Mar 6.

Department of Histology and Embryology, Poznan University of Medical Sciences, Poland.

Background: Galanin-like peptide (Galp) and alarin (Ala) are 2 new members of the galanin peptide family. Galanin (Gal), the "parental" peptide of the entire family, is known to regulate numerous physiological processes, including energy and osmotic homeostasis, reproduction, food intake, and secretion of adrenocortical hormones. Galp and Ala are known to regulate food intake. Read More

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http://www.advances.umed.wroc.pl/ahead-of-print/95039.pdf
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http://dx.doi.org/10.17219/acem/95039DOI Listing
March 2019
2 Reads

[Essential thrombocythemia accompanied by adrenal infarction].

Rinsho Ketsueki 2019 ;60(2):106-111

Department of Hematology, Kyoto City Hospital.

A 64-year-old man presented to the emergency department with sudden-onset upper abdominal pain and pain in the left chest area. His platelet count was 121.7×10/µl. Read More

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http://dx.doi.org/10.11406/rinketsu.60.106DOI Listing
January 2019
5 Reads

1,000 Retroperitoneoscopic Procedures of the Upper Urinary Tract: Analysis of Complications.

Urol Int 2019 Mar 6:1-7. Epub 2019 Mar 6.

Background And Objective: To evaluate risk factors and complications of retroperitoneoscopic procedures of upper urinary tract and adrenal gland.

Methods: From 1994 to 2016, 1,000 retroperitoneal laparoscopies were performed - 476 nephrectomies, 201 adrenalectomies, 103 partial nephrectomies, 91 pyeloplasties, 70 nephro-ureterectomies, and 59 miscellaneous surgeries (diverticulectomy). Data collection was prospective. Read More

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http://dx.doi.org/10.1159/000497038DOI Listing
March 2019
2 Reads

Clinical utility of routine postoperative morning cortisol monitoring in detecting new hypothalamic-pituitary-adrenal axis insufficiency following endoscopic transsphenoidal surgery for sellar lesions.

J Neurosurg 2019 Mar 1:1-5. Epub 2019 Mar 1.

1Department of Neurological Surgery and.

OBJECTIVEHypothalamic-pituitary-adrenal (HPA) axis dysfunction is a well-documented complication of transsphenoidal craniotomy (TSC) for sellar lesions. The authors aimed to assess their multidisciplinary approach to the diagnosis and treatment of postoperative hypocortisolemia utilizing conservative screening methods.METHODSThe authors performed a retrospective review of 257 patients who underwent TSC for pituitary adenoma (PA) or Rathke cleft cyst (RCC) at the University of Southern California between 2012 and 2017. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182521DOI Listing
March 2019
4 Reads

[A Case of Giant Adrenal Endothelial Cyst that was Discovered in Pregnancy and Caused Bleeding Three Years Later].

Hinyokika Kiyo 2019 Jan;65(1):7-11

The Department of Urology, Nagasaki University Graduate School of Biomedical Sciences.

A 39-year-old woman was referred to our hospital after incidental detection of a hypoechoic abdominal mass on ultrasonography at the 11th week of gestation. Magnetic resonance imaging confirmed a 20 cm cystic lesion just cephalad to the left kidney. The patient delivered in the 40th week of gestation without complications. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_1_7DOI Listing
January 2019

The impact of early-life stress on corticosteroid carrier protein levels and 11β-hydroxysteroid dehydrogenase 1 expression in adolescent rats.

Pharmacol Rep 2018 Nov 28;71(2):347-350. Epub 2018 Nov 28.

Institute of Pharmacology, Polish Academy of Sciences, Laboratory of Pharmacology and Brain Biostructure, Kraków, Poland. Electronic address:

Background: Corticosteroid-binding globulin (CBG), albumin and 11β-hydroxysteroid dehydrogenase (11β-HSD) enzymes play crucial roles in the bioavailability of glucocorticoids. Downstream of the adrenal glands, these proteins affect glucocorticoid levels in target tissues. Early-life stress (ELS) is known to program glucocorticoid action at many levels. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.11.003DOI Listing
November 2018

EPHB6 controls catecholamine biosynthesis by up-regulating tyrosine hydroxylase transcription in adrenal gland chromaffin cells.

J Biol Chem 2019 Mar 1. Epub 2019 Mar 1.

Medicine, University of Montreal, Canada.

EPHB6 is a member of the erythropoietin-producing hepatocellular kinase (EPH) family and a receptor tyrosine kinase with a dead kinase domain. It is involved in blood pressure regulation and adrenal gland catecholamine (CAT) secretion, but several facets of EPHB6-mediated CAT regulation are unclear. In this study, using biochemical, RT-qPCR, immunoblotting, and gene microarray assays, we found that EPHB6 up-regulates CAT biosynthesis in adrenal gland chromaffin cells (AGCCs). Read More

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http://dx.doi.org/10.1074/jbc.RA118.005767DOI Listing

Primary Adrenal Angiomatoid Fibrous Histiocytoma With Novel EWSR1-ATF1 Gene Fusion Exon-Exon Breakpoint.

Pediatr Dev Pathol 2019 Mar 1:1093526619830287. Epub 2019 Mar 1.

2 Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore.

We describe the clinical, pathological, and molecular features of a primary adrenal angiomatoid fibrous histiocytoma (AFH) in an 11-year-old girl presenting with pyrexia of unknown origin. We performed next-generation sequencing-based anchored multiplex polymerase chain reaction (Archer® FusionPlex® sarcoma assay), which revealed an EWSR1-ATF1 gene fusion with novel breakpoints in exon 11 of EWSR1 and exon 3 of ATF1. The pyrexia resolved fully after surgical resection, and the patient was disease-free on follow-up at 1 year and 6 months. Read More

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http://dx.doi.org/10.1177/1093526619830287DOI Listing
March 2019
3 Reads

Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population.

J Clin Med 2019 Feb 25;8(2). Epub 2019 Feb 25.

Institute of New Frontier Stroke Research, Hallym University College of Medicine, Chuncheon 24252, Korea.

Genome-wide association studies found genetic variations with modulatory effects for intracranial aneurysm (IA) formations in European and Japanese populations. We aimed to identify the susceptibility of single nucleotide polymorphisms (SNPs) to IA in a Korean population consisting of 250 patients, and 294 controls using the Asian-specific Axiom Precision Medicine Research Array. Twenty-nine SNPs reached a genome-wide significance threshold (5 × 10). Read More

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http://dx.doi.org/10.3390/jcm8020275DOI Listing
February 2019
5 Reads

Effects of nepicastat upon dopamine-β-hydroxylase activity and dopamine and norepinephrine levels in the rat left ventricle, kidney, and adrenal gland.

Clin Exp Hypertens 2019 Mar 1:1-8. Epub 2019 Mar 1.

a Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty Medicine , University of Porto , Porto , Portugal.

Background And Objective: Evaluate the activity of dopamine-β-hydroxylase (DβH) as well as the effect of the DβH inhibitor nepicastat upon enzyme activity and levels of dopamine (DA) and norepinephrine (NE) in the rat left ventricle, kidney, and adrenal glands.

Methods: DβH assay consisted of the enzymatic hydroxylation of tyramine into octopamine, and DA and NE tissues levels were quantified by HPLC-ED.

Results: Nepicastat (30 mg/kg, p. Read More

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http://dx.doi.org/10.1080/10641963.2019.1583245DOI Listing

The transient cortical zone in the adrenal gland: the mystery of the adrenal X-zone.

J Endocrinol 2019 02 1. Epub 2019 Feb 1.

Y Kang, Anatomy, Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, United States.

The X-zone is a transient cortical region enriched in eosinophilic cells located in the cortical-medullary boundary of the mouse adrenal gland. Similar to the X-zone, the fetal zone in human adrenals is also a transient cortical compartment, comprising the majority of the human fetal adrenal gland. During adrenal development, fetal cortical cells are gradually replaced by newly formed adult cortical cells that develop into outer definitive zones. Read More

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http://dx.doi.org/10.1530/JOE-18-0632DOI Listing
February 2019

Early-life adversity programs long-term cytokine and microglia expression within the HPA axis in female Japanese quail.

J Exp Biol 2019 Feb 27. Epub 2019 Feb 27.

School of Psychology and Neuroscience, University of St Andrews, St Andrews, KY16 9JP, UK.

Stress exposure during pre and post-natal development can have persistent and often dysfunctional effects on several physiological systems, including immune function, affecting the ability to combat infection. The neuro-immune response is inextricably linked to the action of the Hypothalamic Pituitary Adrenal (HPA) axis. Cytokines released from neuro-immune cells, including microglia, activate the HPA axis while glucocorticoids in turn regulate cytokine release from microglia. Read More

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http://dx.doi.org/10.1242/jeb.187039DOI Listing
February 2019

A case report on 111In chloride bone marrow scintigraphy in management of adrenal myelolipoma.

Medicine (Baltimore) 2019 Feb;98(8):e14625

Pathology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research.

Rationale: Adrenal myelolipoma is a benign hormone-inactive tumor composed of hematopoietic tissue and mature adipose tissue. Because this tumor tends to be rich in fat, in many cases it can be diagnosed based on computed tomography (CT) or magnetic resonance imaging (MRI) findings alone. However, in the presence of much necrosis, calcification and hematopoietic tissue and/or the absence of much fat, and in cases with tumor apoplexy, this tumor becomes difficult to differentiate from other tumors. Read More

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http://dx.doi.org/10.1097/MD.0000000000014625DOI Listing
February 2019
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5.723 Impact Factor

The Adrenal Gland: Central Relay in Health and Disease.

Exp Clin Endocrinol Diabetes 2019 Feb 27;127(2-03):81-83. Epub 2019 Feb 27.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Germany.

Diseases of the adrenal gland are as important for the general practitioner as for the endocrine specialist. The high prevalence of some adrenal endocrinopathies, such as adrenal incidentalomas (1-2% of the population) and primary aldosteronism (6% of hypertensives), which affect millions of patients, makes adrenal diseases a relevant health issue. The high morbidity and mortality of some of the rarer adrenal diseases, i. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0752-4176
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http://dx.doi.org/10.1055/a-0752-4176DOI Listing
February 2019
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Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation.

PLoS One 2019 27;14(2):e0212638. Epub 2019 Feb 27.

Department of Clinical Sciences, College of Veterinary Medicine and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America.

Gallbladder mucocele formation is an emerging disease in dogs characterized by increased secretion of condensed granules of gel-forming mucin by the gallbladder epithelium and formation of an abnormally thick mucus that can culminate in obstruction of the bile duct or rupture of the gallbladder. The disease is associated with a high morbidity and mortality and its pathogenesis is unknown. Affected dogs have a significantly increased likelihood of concurrent diagnosis of hyperadrenocorticism, hypothyroidism, and hyperlipidemia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212638PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392329PMC
February 2019
6 Reads

Acute spontaneous unilateral adrenal hemorrhage: etiology and imaging findings in six cases.

Radiol Bras 2019 Jan-Feb;52(1):12-16

Hospital Universitário Maria Aparecida Pedrossian da Universidade Federal de Mato Grosso do Sul (HUMAP-UFMS), Campo Grande, MS, Brazil.

Objective: To evaluate the computed tomography characteristics of patients admitted with clinical suspicion of acute adrenal hemorrhage at three centers over a 3-year period and in whom that diagnosis was ultimately confirmed.

Materials And Methods: This was a retrospective analysis of computed tomography findings in patients with suspected acute adrenal hemorrhage. We included only those cases in which the diagnosis was confirmed. Read More

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http://dx.doi.org/10.1590/0100-3984.2018.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383530PMC
February 2019
4 Reads

Biological and clinical insights from genetics of insomnia symptoms.

Nat Genet 2019 Mar 25;51(3):387-393. Epub 2019 Feb 25.

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Read More

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http://dx.doi.org/10.1038/s41588-019-0361-7DOI Listing
March 2019
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Intravascular B-large cell lymphoma: an unexpected diagnosis of an incidental adrenal mass.

J Surg Case Rep 2019 Feb 19;2019(2):rjz048. Epub 2019 Feb 19.

Department of Surgery, 5th Surgical Clinic, Evgenidion Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.

Adrenal incidentalomas originally defined as tumors discovered serendipitously in the course of diagnostic evaluation or follow-up of unrelated disorders, may occasionally pose serious diagnostic challenges. Intravascular large B-cell lymphoma (IVLBCL) may be a rare example of such a case. We present an IVLBCL confined to the adrenal gland in a 52-year-old man focusing on its diagnostic and therapeutic aspects. Read More

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http://dx.doi.org/10.1093/jscr/rjz048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380070PMC
February 2019
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Colorimetric detection of normetanephrine, a pheochromocytoma biomarker, using bifunctionalised gold nanoparticles.

Anal Chim Acta 2019 May 8;1056:146-152. Epub 2019 Jan 8.

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Spain; CIBER de Bioingenierıía, Biomateriales y Nanomedicina (CIBER-BBN), Spain; Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.

A simple and effective colorimetric method for the detection of normetanephrine (NMN), an O-methylated metabolite of norepinephrine, using functionalised gold nanoparticles is described. This metabolite is an important biomarker in the diagnosis of adrenal tumours such as pheocromocytoma or paraganglioma. The colorimetric probe consists of spherical gold nanoparticles (AuNPs) functionalised with two different ligands, which specifically recognize different functional groups in normetanephrine. Read More

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http://dx.doi.org/10.1016/j.aca.2019.01.003DOI Listing
May 2019
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