105,971 results match your criteria Adrenal Gland


RGS4 controls Gαi3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.

J Cell Sci 2020 May 22. Epub 2020 May 22.

Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program. 661 University Ave. 14th Floor, Toronto, ON, M5G 1M1, Canada.

Intracellular pools of the heterotrimeric G-protein alpha-subunit, Gαi3, has been shown to promote growth factor signaling, while at the same time inhibiting the activation of JNK and autophagic signaling following nutrient starvation. The precise molecular mechanisms linking Gαi3 to both stress and growth factor signaling remain poorly understood. Importantly, JNK-mediated phosphorylation of Bcl-2 was shown to activate autophagic signaling following nutrient deprivation. Read More

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http://dx.doi.org/10.1242/jcs.241034DOI Listing

Immunodepression induced by influenza A virus (H1N1) in lymphoid organs functions as a pathogenic mechanism.

Clin Exp Pharmacol Physiol 2020 Jun 4. Epub 2020 Jun 4.

Department of Pathology, the Affiliated Hospital of Southwest Medical University, Luzhoucity, Sichuan Prov, China.

In recent years,the frequency ofinfluenza epidemicsaround the worldhas posed a great threat to the lives of people, especially those in developing countries. However, it is unclear which organs are the targets of influenza A viruses (IAVs) and whathistopathology is caused by IAVs.In this study, BALB/c female mice were infected with H1N1 by nasal inoculation for five days. Read More

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http://dx.doi.org/10.1111/1440-1681.13358DOI Listing

[Regulatory effect of Jiaotai Pills on central and peripheral neurotransmitters in rats with heart-kidney imbalance insomnia].

Zhongguo Zhong Yao Za Zhi 2020 May;45(9):2172-2179

National Institutes for Food and Drug Control Beijing 100053, China.

To explore the pathogenesis of heart and kidney imbalance insomnia and the regulatory effect of Jiaotai Pills, in order to study the changes of central and peripheral neurotransmitters in rat. Insomnia rats with heart and kidney imbalance were induced through intraperitoneal injection with p-chlorophenylalanine(PCPA, 400 mg·kg~(-1)·d~(-1)), and the model rats were intragastrically administrated with Jiaotai Pills(3.3 g·kg~(-1)·d~(-1)) for 7 days. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191230.402DOI Listing

Experience in the application of laparoscopic anatomical adrenalectomy via the renal cortex surface monolayer.

Pak J Med Sci 2020 May-Jun;36(4):717-722

Chunli Zhao, Department of Urology, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, P. R. China.

Objective: To discuss the clinical application of laparoscopic anatomical adrenalectomy via the renal cortex surface in the operation of adrenal masses.

Methods: A retrospective analysis was performed on 231 patients with adrenal masses who were received and cured in the urology department of the Affiliated Hospital of Hebei University from July 2016 to January 2019. All patients received retroperitoneal adrenalectomy by means of laparoscopic anatomical adrenalectomy via the renal cortex surface. Read More

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http://dx.doi.org/10.12669/pjms.36.4.2102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260897PMC

Pheochromocytomas and paragangliomas in children: Data from the Italian Cooperative Study (TREP).

Pediatr Blood Cancer 2020 Jun 3:e28332. Epub 2020 Jun 3.

Pediatric Surgery Unit, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.

Background: Pheochromocytomas (PCs) are neuroendocrine tumors arising from the chromaffin cells of the adrenal gland, and paragangliomas (PGLs) are their extra-adrenal counterparts arising from ganglia along the sympathetic/parasympathetic chain. Surgery is the cornerstone of treatment. A sporatic or inherited germline mutation is commonly associated. Read More

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http://dx.doi.org/10.1002/pbc.28332DOI Listing

Possible long-term endocrine-metabolic complications in COVID-19: lesson from the SARS model.

Endocrine 2020 Jun 2. Epub 2020 Jun 2.

Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.

The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is centralizing the interest of the scientific world. In the next months, long-term consequences on the endocrine system may arise following COVID-19. In this article, we hypothesized the effects of SARS-CoV-2 taking into account what learned from the severe acute respiratory syndrome coronavirus (SARS-CoV) that caused SARS in 2003. Read More

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http://dx.doi.org/10.1007/s12020-020-02349-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266418PMC

Endocrine complications of COVID-19: what happens to the thyroid and adrenal glands?

J Endocrinol Invest 2020 Jun 1. Epub 2020 Jun 1.

Diabetes Unit, Department of Advanced Medical and Surgical Sciences, University of Campania ''Luigi Vanvitelli'', 80138, Naples, Italy.

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http://dx.doi.org/10.1007/s40618-020-01311-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265876PMC

[Mediastinal myelolipoma: a clinicopathological analysis of 4 cases].

Authors:
J Rao J P Yuan J S Hu

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):613-615

Department of Pathology, Renmin Hospital of Yunmeng County, Xiaogan City, Hubei Province, Xiaogan 432500, China.

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http://dx.doi.org/10.3760/cma.j.cn112151-20190919-00513DOI Listing

Rats Lacking Dopamine Transporter Display Increased Vulnerability and Aberrant Autonomic Response to Acute Stress.

Biomolecules 2020 May 31;10(6). Epub 2020 May 31.

Department of Neurology and Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

The activity of the hypothalamus-pituitary-adrenal (HPA) axis is pivotal in homeostasis and presides the adaptative response to stress. Dopamine Transporter (DAT) plays a key role in the regulation of the HPA axis. We used young adult female DAT Knockout (KO) rats to assess the effects of DAT ablation (partial, heterozygous DAT+/-, or total, homozygous DAT-/-) on vulnerability to stress. Read More

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http://dx.doi.org/10.3390/biom10060842DOI Listing

The study on the risk of other endocrine glands autoimmune diseases in patients with type 1 diabetes mellitus.

Medicine (Baltimore) 2020 May;99(22):e20437

Key Laboratory of Environment and Population Health of Hebei Province, Department of Epidemiology and Statistics, Hebei Medical University, Shijiazhuang, Hebei, PR China.

To study the changes of pancreas, thyroid, adrenal, parathyroid and gonadal organ-specific antibodies in patients with type 1 diabetic patients and to explore the risk of development to other endocrine gland autoimmune diseases.Fifty one patients with type 1 diabetes mellitus were selected. ELISA was used to detect islet, adrenal gland, Parathyroid, gonadal organ-specific antibody levels, the level of thyroid-related antibodies by lectrochemiluminescence. Read More

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http://dx.doi.org/10.1097/MD.0000000000020437DOI Listing

Sarcoidosis and adrenal angiomyolipoma - A rare tumor and a rarer coincidence.

Sarcoidosis Vasc Diffuse Lung Dis 2017 28;34(1):81-84. Epub 2017 Apr 28.

Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

Angiomyolipoma is a benign mesenchymal tumor occurring in about 0.3 % of the general population. Angiomyolipoma of the adrenal gland is a rare entity, and only 5 cases have been reported so far in English literature. Read More

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http://dx.doi.org/10.36141/svdld.v34i1.4506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170107PMC

Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia.

Endocrinol Diabetes Metab Case Rep 2020 Apr 29;2020. Epub 2020 Apr 29.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Summary: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing syndrome (CS). This condition is characterized by glucocorticoid and/or mineralocorticoid excess, and is commonly regulated by aberrant G-protein coupled receptor expression may be subclinical, allowing the disease to progress for years undetected. Inhibin A is a glycoprotein hormone and tumor marker produced by certain endocrine glands including the adrenal cortex, which has not been previously investigated as a potential tumor marker for PBMAH. Read More

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http://dx.doi.org/10.1530/EDM-20-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219132PMC

Primary adrenal lymphoma: a case of hiccups.

Oxf Med Case Reports 2020 Apr 23;2020(4):omaa030. Epub 2020 May 23.

Department of Medicine, John Hunter Hospital, Newcastle, NSW, Australia.

Approximately 250 cases of primary adrenal lymphoma have been reported. We describe an unusual presentation of this condition. Our patient is a 65-year-old male whom presented to the emergency department with 4 days of severe persistent hiccups. Read More

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http://dx.doi.org/10.1093/omcr/omaa030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243721PMC

A rare case of adrenal collision tumor: Myelolipoma and schwannoma in the adrenal gland.

SAGE Open Med Case Rep 2020 9;8:2050313X20921074. Epub 2020 May 9.

Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA.

Adrenal collision tumors refer to coexistence of two adjacent, but histologically distinct, neoplasms involving the adrenal gland without histologic admixture at the interface. Myelolipoma is a rare but benign neoplasm. As its name implies, displays both mature adipose tissue and hematopoietic elements. Read More

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http://dx.doi.org/10.1177/2050313X20921074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234350PMC

First proof of association between autoimmune polyglandular syndrome and multiple endocrine neoplasia in humans.

Endocr J 2020 May 29. Epub 2020 May 29.

Department of Medicine (DIMED), Endocrinology Unit, Padua University, Padua, Italy.

Autoimmune Addison's disease (AAD) is a rare condition occurring either in isolation or associated with other autoimmune diseases as part of an autoimmune polyglandular syndrome (APS) type 1, 2 or 4. Multiple endocrine neoplasia (MEN) type 1, 2 or 4 is a hereditary autosomal dominant cancer syndrome. Medullary thyroid carcinoma and pheochromocytoma are neoplasms common to MEN-2a and MEN-2b. Read More

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http://dx.doi.org/10.1507/endocrj.EJ20-0099DOI Listing

Feasibility and Safety of Laparoscopic Radical Distal Pancreatosplenectomy with Adrenalectomy in Advanced Pancreatic Cancer.

Ann Surg Oncol 2020 May 31. Epub 2020 May 31.

Department of Hepatobiliary and Pancreatic Surgery, Yonsei University College of Medicine, Seoul, Korea.

Introduction: Pancreatic adenocarcinoma is a lethal condition with poor outcomes and an increasing incidence.1 However, recent meta-analysis reported improved survival and R0 resection rate following neoadjuvant chemotherapy with subsequent surgery in initially unresectable pancreatic cancer.2 In addition, as a result of technological advances during the past 2 decades, even in pancreatic cancers, minimally invasive surgery (MIS) approaches are being used more frequently and safely. Read More

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http://dx.doi.org/10.1245/s10434-020-08670-9DOI Listing

Retroperitoneoscopy in the horse: anatomical study of the retroperitoneal perirenal space and description of a surgical approach.

Equine Vet J 2020 May 30. Epub 2020 May 30.

Department of Surgery, Equine Clinic, ONIRIS, National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.

Background: Surgical approaches to the kidneys and perirenal structures are uncommonly performed in horses and several complications have been described with the current procedures.

Objective: To describe the anatomy of the retroperitoneal perirenal space and investigate a retroperitoneal minimally invasive approach to access the kidney and perirenal structures in horses.

Study Design: Descriptive, cadaveric study. Read More

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http://dx.doi.org/10.1111/evj.13293DOI Listing

Circadian distribution of autostimulations in rVNS therapy in patients with refractory focal epilepsy.

Epilepsy Behav 2020 May 27;110:107144. Epub 2020 May 27.

Department of Neurosciences and Rehabilitation, Tampere University Hospital, P.O. Box 2000, Tampere FI-33521, Finland; Tampere University, Faculty of Medicine and Health Technology, FI-33014 Tampere, Finland.

Background: Responsive vagus nerve stimulation (rVNS) utilizes an electrocardiograph (ECG)-based algorithm to detect rapid sympathetic activations associated with the onset of a seizure. Abrupt sympathetic activation may also be associated with nocturnal arousals between sleep cycles or transitioning from sleep to wakefulness, a period in which many patients with epilepsy experience seizures. Because of circadian changes in autonomic function, we hypothesized that the autostimulation feature might also behave in a circadian fashion. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107144DOI Listing

Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6).

BMC Neurosci 2020 May 29;21(1):25. Epub 2020 May 29.

Department of Psychosocial Science, University of Bergen, Bergen, Norway.

Background: Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the effects of social stress in rats, i.e. Read More

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http://dx.doi.org/10.1186/s12868-020-00574-4DOI Listing

Transethnic Meta-analysis of Genome-wide Association Studies Identifies Three New Loci and Characterizes Population-specific Differences for Coronary Artery Disease.

Circ Genom Precis Med 2020 May 29. Epub 2020 May 29.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

- Genome-wide association studies (GWAS) provided many biological insights into coronary artery disease (CAD), but these studies were mainly performed in Europeans. GWAS in diverse populations have the potential to advance our understanding of CAD. - We conducted two GWAS for CAD in the Japanese population, which included 12,494 cases and 28,879 controls, and 2,808 cases and 7,261 controls, respectively. Read More

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http://dx.doi.org/10.1161/CIRCGEN.119.002670DOI Listing

Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review.

World J Surg Oncol 2020 May 28;18(1):109. Epub 2020 May 28.

Department of Hepato-Biliary-Pancreatic and Breast Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Background: The most common sites of recurrence after liver transplantation for hepatocellular carcinoma (HCC) have been reported to be the liver, lung, bone, and adrenal glands, but there have also been many reports of cases of multiple recurrence. The prognosis after recurrence is poor, with reported median survival after recurrence of HCC ranging from 9 to 19 months. Here, we report a case of long-term survival after recurrence of pharyngeal metastasis following living-donor liver transplantation (LDLT) for HCC within the Milan criteria, by resection of the metastatic region and cervical lymph node dissection. Read More

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http://dx.doi.org/10.1186/s12957-020-01873-0DOI Listing

Attention-Deficit/Hyperactivity Disorder, Its Pharmacotherapy, and Adrenal Gland Dysfunction: A Nationwide Population-Based Study in Taiwan.

Int J Environ Res Public Health 2020 May 25;17(10). Epub 2020 May 25.

Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

This study aims to examine the co-occurrence rate of attention deficit hyperactivity disorder (ADHD) and adrenal gland disorders, as well as whether pharmacotherapy may affect ADHD patients' risk of developing adrenal gland disorder. One group of patients newly diagnosed with ADHD ( = 75,247) and one group of age- and gender-matching controls ( = 75,247) were chosen from Taiwan's National Health Insurance database during the period of January 1999 to December 2011. Both patients and controls were monitored through December 31, 2011, in order to identify the occurrence of adrenal gland disorders (ICD-9-CM code 255. Read More

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http://dx.doi.org/10.3390/ijerph17103709DOI Listing

LC-MS/MS analyses of bile and histological analyses of thymus as diagnostic tools to detect low dose dexamethasone illicit treatment in beef cattle at slaughterhouse.

Steroids 2020 May 25;160:108671. Epub 2020 May 25.

Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", 06126 - Perugia, Italy. Electronic address:

Dexamethasone (DXM) is a synthetic adrenal corticosteroid with anti-inflammatory properties used for therapeutic purposes in a wide range of pathologies and of the most common corticosteroids used for anabolic purposes in beef cattle. It is proven that DXM induces histological changes, traceable as increasing fatty infiltration of the thymus associated with a concurrent decrease of the cortex-medulla ratio, so the histological examination of the thymus gland has been established as an indirect morphological biomarker. The aim of the present study is to compare thymus histology and DXM concentrations in biological fluids collected at slaughterhouse after 1 month of DXM treatment. Read More

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http://dx.doi.org/10.1016/j.steroids.2020.108671DOI Listing

Adrenal paracoccidioidomycosis

Biomedica 2020 05 1;40(Supl. 1):20-22. Epub 2020 May 1.

Departamento de Patología, Universidad de Antioquia, Medellín, Colombia.

Primary adrenal insufficiency is a defect in glucocorticoid, mineralocorticoid and sexual androgens production. Patients with this disorder have low cortisol levels and aldosterone deficiency with concomitant hyponatremia and hyperkalemia. The most common etiology of this disease is the production of antibodies against the enzyme 21 hydroxylase. Read More

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http://dx.doi.org/10.7705/biomedica.4844DOI Listing

Report of two rare cases of adrenal incidentalomas with different origins: revisiting pathological and radiological findings with a short review of the literature.

J Egypt Natl Canc Inst 2020 May 27;32(1):25. Epub 2020 May 27.

Urology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Background: Adrenal tumors can be detected incidentally in 4 to 8% of patients radiologically. Adenomas, pheochromocytomas, and adrenocortical carcinomas represent the most common tumors of the adrenal glands. Rare histopathological findings are uncommon. Read More

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http://dx.doi.org/10.1186/s43046-020-00039-zDOI Listing

Report: central diabetes insipidus and schwannoma in a male with X-linked congenital adrenal hypoplasia.

BMC Endocr Disord 2020 May 27;20(1):73. Epub 2020 May 27.

Department of Pediatrics, Gyeongsang National University School of Medicine, 92 Chilam-dong, Jinju, Gyeongnam, 660-751, South Korea.

Background: DAX1 mutations are related to the X-linked form of adrenal hypoplasia congenita (AHC) in infancy and to hypogonadotropic hypogonadism (HH) in puberty. We report a male patient affected by X-linked AHC who presented with central diabetes insipidus and schwannoma in adulthood, which has not been described in association with AHC.

Case Presentation: A 36-day-old male infant who presented with severe dehydration was admitted to the intensive care unit. Read More

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http://dx.doi.org/10.1186/s12902-020-00553-0DOI Listing

Effect of genistein and estradiol on the adrenal cortex of the ovariectomized adult female albino rats.

Folia Morphol (Warsz) 2020 May 27. Epub 2020 May 27.

Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Genistein, a naturally occurring soy isoflavone, attracts interest as an effective and safe alternative to hormone replacement therapy for menopausal proplems. The aim of the current study was to compare between the effect of genistein and estradiol on the adrenal cortex of the ovariectomized adult female albino rats. Twenty rats were used in the current study and divided into 4 groups, five rats in each group; group 1 (control nonovariectomized), group 2 (ovariectomized), group 3 (ovariectomized + genistein) and group 4 (ovariectomized+ estradiol). Read More

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http://dx.doi.org/10.5603/FM.a2020.0056DOI Listing

CT and MR imaging of acute adrenal disorders.

Abdom Radiol (NY) 2020 May 26. Epub 2020 May 26.

The Ottawa Hospital, the University of Ottawa, 1053 Carling Avenue, Ottawa, ON, K1Y 4E9, Canada.

The adrenal glands may be overlooked when evaluating acutely ill patients. Acute adrenal disorders may result from complications of an underlying systemic disease, which may be unsuspected clinically. Various acute adrenal emergencies including trauma, spontaneous hemorrhage, infarction and infection can be diagnosed using CT and MRI; however, in uncertain cases follow-up to resolution of imaging findings or histological sampling may be required for diagnosis. Read More

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http://dx.doi.org/10.1007/s00261-020-02580-wDOI Listing

Diagnostic utility of cytology smears and cell block in adrenal lesions.

Diagn Cytopathol 2020 May 23. Epub 2020 May 23.

Department of Endocrinology, IPGME&R, Kolkata, India.

Background: Cytology of the adrenal gland is a less performed technique even in tertiary care centres; yet cytological evaluation is an important diagnostic tool for assessment of adrenal lesions. Our objective was to evaluate the diagnostic utility of FNAC smears and cellblock with immunohistochemistry (IHC) in lesions of the adrenal.

Material And Methods: We had a total of 50 cases over a period of 2 years where both FNAC smears and cellblocks were taken. Read More

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http://dx.doi.org/10.1002/dc.24484DOI Listing

Computed tomography findings of early-stage TAFRO syndrome and associated adrenal abnormalities.

Eur Radiol 2020 May 21. Epub 2020 May 21.

Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Objectives: To compare CT findings of early (within 3 weeks post-onset)- and later (within 1 month before or after diagnostic criteria were satisfied, and later than 3 weeks post-onset) stage thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome.

Methods: Between 2014 and 2019, 13 patients with TAFRO syndrome (8 men and 5 women; mean age, 54.9 years) from nine hospitals were enrolled. Read More

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http://dx.doi.org/10.1007/s00330-020-06919-1DOI Listing

A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice.

PLoS One 2020 21;15(5):e0233386. Epub 2020 May 21.

Graduate School of Media and Governance, Keio University, Fujisawa, Kanagawa, Japan.

Salt is an essential nutrient; however, excessive salt intake is a prominent public health concern worldwide. Various physiological functions are associated with circadian rhythms, and disruption of circadian rhythms is a prominent risk factor for cardiovascular diseases, cancer, and immune disease. Certain nutrients are vital regulators of peripheral circadian clocks. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233386PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241774PMC

The Association of ARMC5 with the Renin-Angiotensin-Aldosterone System, Blood Pressure and Glycemia in African Americans.

J Clin Endocrinol Metab 2020 May 21. Epub 2020 May 21.

The Ohio State University, Columbus, Ohio, USA.

Context: Armadillo repeat containing 5 (ARMC5) on Chromosome 16 is an adrenal gland tumor suppressor gene associated with primary aldosteronism, especially among African Americans (AAs). We examined the association of ARMC5 variants with aldosterone, plasma renin activity (renin), blood pressure, glucose and hemoglobin A1c (A1c) in community-dwelling AAs.

Methods: The Jackson Heart Study is a prospective cardiovascular cohort study in AAs with baseline data collection between 2000-2004. Read More

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http://dx.doi.org/10.1210/clinem/dgaa290DOI Listing

Assessment of PARP-1 Distribution in Tissues of Cynomolgus Monkeys.

J Histochem Cytochem 2020 Jun 21;68(6):413-435. Epub 2020 May 21.

Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC, Canada.

The poly(ADP-ribose) polymerase 1 (PARP-1) enzyme has received much attention in the last decade due to its promising role in cancer therapeutics. Despite the expanding use of PARP inhibitors in cancer therapy, little is known about PARP-1 tissue distribution. Our study provides a detailed survey of PARP-1 tissue and cellular distribution using well-preserved cynomolgus monkey organs and a well-characterized, highly specific monoclonal PARP-1 antibody. Read More

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http://dx.doi.org/10.1369/0022155420926022DOI Listing

Retroperitoneal bronchogenic cyst resembling an adrenal tumor: two case reports and literature review.

J Int Med Res 2020 May;48(5):300060520925673

Department of Radiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Bronchogenic cysts are primitive, foregut-derived developmental anomalies with bronchial-type, pseudostratified cylindrical epithelium. They are usually discovered in the thorax. The occurrence of such cysts in the retroperitoneum is extremely rare. Read More

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http://dx.doi.org/10.1177/0300060520925673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243399PMC

The effects of prenatal dexamethasone exposure and fructose challenge on pituitary-adrenocortical activity and anxiety-like behavior in female offspring.

Tissue Cell 2020 Feb 16;62:101309. Epub 2019 Oct 16.

Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, 142 despota Stefana Blvd., 11060, Belgrade, Serbia.

Prenatal glucocorticoid overexposure could largely influence pituitary-adrenal activity and anxiety-like behavior in offspring. Our aim was to study the possible potentiating effect of moderate dose of fructose - common ingredient of today's diet - on prenatal glucocorticoid treatment-induced hypothalamo-pituitary-adrenal (HPA) axis changes. Pregnant female rats were treated with multiple dexamethasone (Dx) doses (3 x 0. Read More

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http://dx.doi.org/10.1016/j.tice.2019.101309DOI Listing
February 2020

[Painful orbital swelling in a 61-year-old female patient].

Internist (Berl) 2020 May 19. Epub 2020 May 19.

Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, HELIOS Klinikum Krefeld, Lutherplatz 40, 47805, Krefeld, Deutschland.

Adenocarcinoma of the esophagus is the oncologic entity with the most progressive incidence in western countries over the last 30 years. This is caused by, among other factors, a growing rate of obesity and the associated gastroesophageal reflux disease. Typical sites of metastasis include the liver, lymph nodes and peritoneum. Read More

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http://dx.doi.org/10.1007/s00108-020-00802-3DOI Listing

Hernia after retroperitoneoscopic adrenalectomy, case report.

Gland Surg 2020 Apr;9(2):442-446

Resident in Surgery, Klinik für Viszeralchirurgie, Kantonsspital Aarau, Aarau, Switzerland.

We report the first case of a previously undocumented complication after posterior retroperitoneal adrenalectomy (PRA). Extensive diagnostic procedures for persisting abdominal pain led to diagnosis of an incisional hernia (IH) approximately 2.5 years after surgery for a pheochromocytoma of the right adrenal gland. Read More

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http://dx.doi.org/10.21037/gs.2020.01.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225460PMC

Not all adrenal incidentalomas require biochemical testing to exclude pheochromocytoma: Mayo clinic experience and a meta-analysis.

Gland Surg 2020 Apr;9(2):362-371

Department of Surgery, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Background: Excluding a pheochromocytoma is important when a patient presents with an incidentally discovered adrenal mass. However, biochemical testing for pheochromocytoma can be cumbersome, time consuming, or falsely positive. Our objective was to determine if unenhanced computed tomography (CT) imaging alone can be used to rule out pheochromocytoma. Read More

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http://dx.doi.org/10.21037/gs.2020.03.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225448PMC

AQP2 as a diagnostic immunohistochemical marker for pheochromocytoma and/or paraganglioma.

Gland Surg 2020 Apr;9(2):200-208

Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.

Background: Aquaporin2 (AQP2) is water channel protein that is widely distributed among mammalian tissues and plays a major role in water homeostasis. However, little is known about the expression and significance of AQP2 in human adrenal tumors. Thus, we performed an immunohistochemical investigation of AQP2 in normal and neoplastic adrenal tissues. Read More

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http://dx.doi.org/10.21037/gs.2020.01.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225480PMC

Melatonin and alcohol-related disorders.

Chronobiol Int 2020 May 18:1-23. Epub 2020 May 18.

Department of Zoology and Animal Physiology, Institute of Biology and Earth Sciences, Pomeranian University in Słupsk, Słupsk, Poland.

This review concerns the current knowledge of melatonin and alcohol-related disorders. Chronobiological effects of ethanol are related to melatonin suppression and in relation to inflammation, stress, free radical scavenging, autophagy and cancer risk. It is postulated that both alcohol- and inflammation-induced production of reactive oxygen species (ROS) alters cell membrane properties leading to tissue dysfunction and, subsequent further ROS production. Read More

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http://dx.doi.org/10.1080/07420528.2020.1761372DOI Listing

An Autopsy Case of Mixed Connective Tissue Disease Complicated by Thrombotic Thrombocytopenic Purpura.

Intern Med 2020 15;59(10):1315-1321. Epub 2020 May 15.

Department of Rheumatology, Fukushima Medical University School of Medicine, Japan.

We herein report a patient with mixed connective tissue disease (MCTD) who had been stable for years but suddenly developed thrombotic thrombocytopenic purpura (TTP). The patient showed a clinical pentad of signs of TTP, low activity of ADAMTS13, and positivity of anti-ADAMTS13 antibodies. She did not respond to plasma exchange or steroid therapy and died five days after admission. Read More

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http://dx.doi.org/10.2169/internalmedicine.3939-19DOI Listing

Primary Hydatid Cyst of the adrenal gland: A case report and a review of the literature.

Int J Surg Case Rep 2020 7;70:154-158. Epub 2020 May 7.

Urology Department, Charles Nicolle Hospital, Tunis, Tunisia.

Introduction: In North Africa which is an endemic region for Hydatid Cyst, Tunisia is considered as an endemic country. The liver and lungs are common locations for Hydatid Cysts, whereas the Adrenal Glands are unusual and rare locations.

Presentation Of Case: Here is a report of primary Hydatid Cyst in a 55-year old patient, with left hypochondrium pain as chief complain. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229415PMC

18F-FDG PET/CT of a Rare Case of an Adenomatoid Tumor of the Adrenal Gland.

Clin Nucl Med 2020 Jul;45(7):e331-e333

From the Nuclear Medicine.

A 28-year old man, with previous history of chronic abdominal pain, was referred to our nuclear medicine center for an F-FDG PET/CT following the fortuitous discovery of a 48-mm right adrenal gland lesion of heterogeneous density at the CT scan. The PET/CT showed an isolated heterogeneous significant uptake evocative of neoplasia. Surprisingly, the anatomopathological analysis after surgery revealed an adenoid tumor of the adrenal gland. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003097DOI Listing

Bilateral adrenal histoplasmosis presenting as adrenal insufficiency in an immunocompetent host in the Philippines.

BMJ Case Rep 2020 May 12;13(5). Epub 2020 May 12.

Department of Medicine, Division of Infectious Disease, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Disseminated histoplasmosis, with the adrenal glands as being the only site of demonstrable disease in an immunocompetent adult, is a rare infection leading to adrenal insufficiency. This disease carries high mortality when unrecognised. We describe the first reported case of adrenal histoplasmosis in the Philippines in a 72-year-old immunocompetent, Filipino man who presented with a 3-month history of intermittent flank pain, weight loss and generalised weakness. Read More

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http://dx.doi.org/10.1136/bcr-2020-234935DOI Listing

Adrenal Gland and Gastric Malignant Melanoma without Evidence of Skin Lesion Treated with the Oncolytic Virus Rigvir.

Case Rep Oncol 2020 Jan-Apr;13(1):424-430. Epub 2020 Apr 17.

Rigvir, Riga, Latvia.

Adrenal gland melanoma is an extremely rare diagnosis with less than 20 cases reported. The criteria for diagnosing adrenal gland melanoma include involvement of only one adrenal gland, presence of melanin pigment in the histological examination of the tumor tissue, no primary melanoma tumor in any other organ, and no history of resection of pigmented lesions. However, it is complicated to rule out melanoma of unknown primary origin. Read More

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http://dx.doi.org/10.1159/000506978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204777PMC

A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review.

Case Rep Gastroenterol 2020 Jan-Apr;14(1):186-196. Epub 2020 Apr 21.

Gastroenterology and Hepatology, East Orange Department of Veteran's Affair, East Orange, New Jersey, USA.

Lung cancer is a common malignancy which is frequently found to metastasize to distant sites including bone, liver, and adrenal glands. There are rare reports of metastases to the gastrointestinal (GI) tract, with the duodenum being the most uncommon. We present a rare case of a poorly differentiated lung carcinoma metastasizing to the duodenum. Read More

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http://dx.doi.org/10.1159/000506927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204736PMC

Clinical efficacy of Stereotactic Body Radiation Therapy (SBRT) for adrenal gland metastases: A multi-center retrospective study from China.

Sci Rep 2020 May 12;10(1):7836. Epub 2020 May 12.

Department of Radiation Oncology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.

To evaluate the efficacy and safety of CyberKnife Stereotactic Body Radiation Therapy (SBRT) in the treatment of adrenal gland metastases (AGM), we designed a large-scale multicenter retrospective study to report the safety and efficacy of SBRT for inoperable AGM. In this study, 75 (61 males, 14 females) patients with 84 AGM and Karnofsky performance score ≥70 were treated by SBRT from October 2006 to January 2017. Of these, the purpose of treatment were controlling all known metastatic sites for 21 patients while 54 for palliation of bulky adrenal metastases. Read More

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http://dx.doi.org/10.1038/s41598-020-64770-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217854PMC

Mediastinal ganglioneuroma diagnosed by transesophageal endoscopic ultrasound guided fine needle aspiration (EUS-FNA).

Diagn Cytopathol 2020 May 12. Epub 2020 May 12.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.

Ganglioneuromas are rare benign tumors that arise from the sympathetic nerve fibers and represent the final maturation stage of neuroblast tumors. The most common sites of involvement in the body include posterior mediastinum, followed by retroperitoneum, adrenal gland, and soft tissues of the head and neck. In the mediastinum, this tumor is most frequently located in posterior compartment, together with other neurogenic tumors. Read More

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http://dx.doi.org/10.1002/dc.24445DOI Listing