107,379 results match your criteria Adrenal Gland

The expression of mimecan in adrenal tissue plays a role in an organism's responses to stress.

Aging (Albany NY) 2021 May 10;13. Epub 2021 May 10.

The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostic and Endocrinology, Shanghai Ninth People’s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao tong University School of Medicine, Shanghai 200011, China.

Mimecan encodes a secretory protein that is secreted into the human serum as two mature proteins with molecular masses of 25 and 12 kDa. We found 12-kDa mimecan to be a novel satiety hormone mediated by the upregulation of the expression of interleukin (IL)-1β and IL-6 in the hypothalamus. Mimecan was found to be expressed in human pituitary corticotroph cells and was up-regulated by glucocorticoids, while the secretion of adrenocorticotropic hormone (ACTH) in pituitary corticotroph AtT-20 cells was induced by mimecan. Read More

View Article and Full-Text PDF

Urinary involvement in Erdheim-Chester disease: computed tomography imaging findings.

Abdom Radiol (NY) 2021 May 10. Epub 2021 May 10.

Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Purpose: To describe the urological manifestations of Erdheim-Chester disease (ECD) and their computed tomography (CT) findings.

Methods: We retrospectively reviewed 48 patients diagnosed with ECD at Peking Union Medical College Hospital from January 2014 to January 2020. Twenty-four patients exhibited urological manifestations. Read More

View Article and Full-Text PDF

Intestinal-type Adenocarcinoma Presenting as a Mandibular Mass: An Unusual Presentation.

Contemp Clin Dent 2021 Jan-Mar;12(1):99-101. Epub 2021 Mar 20.

Department of Dentistry (Cranio-Maxillofacial Surgery), AIIMS, Rishikesh, Uttarakhand, India.

Intestinal-type adenocarcinoma is an aggressive malignancy with the rare possibility of metastatic spread to the mandible. We represent a case of a 30-year-old female patient who reported with a chief complaint of a right mandibular mass for 4 months. Orthopantomogram X-ray observed an ill-defined lytic lesion with severe periosteal reaction. Read More

View Article and Full-Text PDF

Ischiorectal fossa metastasis from colon cancer: Case report of a rare entity and review of literature.

Int J Surg Case Rep 2021 Apr 27;82:105912. Epub 2021 Apr 27.

Department of Surgery, King Fahad Specialist Hospital-Dammam, Saudi Arabia.

Introduction And Importance: Colorectal cancer is one of the most common cancers both nationally and internationally. It commonly metastases to local lymph nodes, liver and lungs, with few reported cases of rare sites of metastasis such as adrenal glands, breast and skin.

Case Presentation: We report a 55-year-old-female admitted as case of large bowel obstruction and unintentional weight loss. Read More

View Article and Full-Text PDF

An increase in normetanephrine in hair follicles of acne lesions through the sympatho-adrenal medullary system in acne patients with anxiety.

J Dermatol 2021 May 7. Epub 2021 May 7.

Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.

Acne vulgaris, a chronic inflammatory skin disease, has been associated with not only sebaceous gland dysfunction but also various endogenous and exogenous stresses. Since sebaceous glands are under neuroendocrine control, including the hypothalamic-pituitary-adrenal axis and neuro-autocrine mechanisms, it remains unclear how psychological stress relates to the pathogenesis of acne. In this study, we investigated the relationship between psychological stress and catecholamine in acne lesions from 18 patients with mild or moderate acne. Read More

View Article and Full-Text PDF

Can abdominal CT features predict autonomous cortisol secretion in patients with adrenal nodules?

Abdom Radiol (NY) 2021 May 7. Epub 2021 May 7.

Department of Surgery, Davis Medical Center, University of California, 2221 Stockton Blvd., Sacramento, CA, 95817, USA.

Purpose: To determine if CT features of adrenal nodules and of the remainder of the abdomen can predict autonomous cortisol secretion (ACH) in patients with adrenal nodules, and to identify a nodule size threshold below which ACH is unlikely.

Methods: Retrospective review of adult patients with adrenal nodules who underwent CT of abdomen and 1-mg Dexamethasone suppression test within 1 year of each other. Patients were considered to have no ACH if serum cortisol was ≤ 1. Read More

View Article and Full-Text PDF

A 45-year-old female patient with Sheehan's syndrome presenting with imminent adrenal crisis: a case report.

J Med Case Rep 2021 May 8;15(1):229. Epub 2021 May 8.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Sheehan's syndrome is hypopituitarism due to pituitary gland necrosis resulting from hemorrhagic shock during pregnancy. It is a rare complication with varied manifestations and a considerable delay in diagnosis.

Case Presentation: We describe the case of a 45-year-old Ethiopian woman who presented with generalized fatigue for 18 years which progressed to anorexia, nausea, vomiting, diarrhea, and abdominal pain of 6 years' duration, for which she was treated symptomatically throughout these years. Read More

View Article and Full-Text PDF

Angiosarcoma of the Adrenal Gland.

Lori A Erickson

Mayo Clin Proc 2021 05;96(5):1376-1378

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

View Article and Full-Text PDF

Regulation of arsenic methylation: identification of the transcriptional region of the human AS3MT gene.

Cell Biol Toxicol 2021 May 6. Epub 2021 May 6.

Department of Cellular Biology and Pharmacology, Florida International University, Herbert Wertheim College of Medicine, Miami, FL, 33199, USA.

The human enzyme As(III) S-adenosylmethionine methyltransferase (AS3MT) catalyzes arsenic biotransformations and is considered to contribute to arsenic-related diseases. AS3MT is expressed in various tissues and cell types including liver, brain, adrenal gland, and peripheral blood mononuclear cells but not in human keratinocytes, urothelial, or brain microvascular endothelial cells. This indicates that AS3MT expression is regulated in a tissue/cell type-specific manner, but the mechanism of transcriptional regulation of expression of the AS3MT gene is not known. Read More

View Article and Full-Text PDF

Adrenal and Hepatic Venous Sampling in a Case of Aldosterone-Producing Adrenocortical Carcinoma with Hepatic Metastasis.

Case Rep Endocrinol 2021 14;2021:5584198. Epub 2021 Apr 14.

Division of Endocrinology and Metabolism, Japanese Red Cross Musashino Hospital, Tokyo, Japan.

Background: Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. ACCs often secrete adrenal steroid hormones including cortisol and androgens; however, aldosterone-producing ACC is very rare. Although adrenal production of aldosterone is assessed by adrenal venous sampling, the use of sampling from the relevant vein to assess aldosterone production from a tumor arising from ACC metastasis has not been previously reported. Read More

View Article and Full-Text PDF

The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.

Cell Rep 2021 May;35(5):109075

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8501, Japan; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan. Electronic address:

In the early fetal stage, the gonads are bipotent and only later become the ovary or testis, depending on the genetic sex. Despite many studies examining how sex determination occurs from biopotential gonads, the spatial and temporal organization of bipotential gonads and their progenitors is poorly understood. Here, using lineage tracing in mice, we find that the gonads originate from a T primitive streak through WT1 posterior intermediate mesoderm and appear to share origins anteriorly with the adrenal glands and posteriorly with the metanephric mesenchyme. Read More

View Article and Full-Text PDF

[Bladder paraganglioma: Report of two cases and a literature review.]

Arch Esp Urol 2021 May;74(4):445-449

Servicio de Oncología Médica. Hospital General Universitario de Elche. España. Unidad de Consejo Genético. Hospital General Universitario de Elche. España.

Objective: Description of two incidental cases of bladder paraganglioma in women and review of the published literature.

Methods: A bibliographic search was carried out in Medline over the last 10 years according to the terms "urinary bladder" and "paraganglioma".

Results: Bladder paraganglioma (BP) accounts for less than 0. Read More

View Article and Full-Text PDF

Endocrine emergencies in anesthesia.

Curr Opin Anaesthesiol 2021 Jun;34(3):326-334

Yale University School of Medicine, New Haven, Connecticut, USA.

Purpose Of Review: An increasing number of patients with endocrine disorders will present to the operating rooms. In this review, we outline the common endocrine disorders that the anesthesiologist may face in the perioperative time span, review the controversies in optimal management, as well as summarize the recent literature for the management of these complex patients.

Recent Findings: Perioperative management of pheochromocytoma and paraganglioma has been facilitated by improved medical management and the adoption of minimally invasive surgical techniques. Read More

View Article and Full-Text PDF

Clinical Characteristics, Management, and Potential Biomarkers of Endocrine Dysfunction Induced by Immune Checkpoint Inhibitors.

Endocrinol Metab (Seoul) 2021 Apr 27;36(2):312-321. Epub 2021 Apr 27.

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Immune-related adverse events (irAEs) affecting the endocrine glands are among the most frequent irAEs induced by immune checkpoint inhibitors (ICIs) and include hypopituitarism, primary adrenal insufficiency, thyrotoxicosis, hypothyroidism, hypoparathyroidism, and type 1 diabetes mellitus. Since the incidence and clinical features of endocrine irAEs vary according to the ICI used, it is important to understand the characteristics of these irAEs and to manage each one appropriately. Since some endocrine irAEs, including adrenal crisis and diabetic ketoacidosis, are potentially life-threatening, predicting the risk of endocrine irAEs before their onset is critical. Read More

View Article and Full-Text PDF

Single-cell transcriptomes reveal characteristic features of cell types within the human adrenal microenvironment.

J Cell Physiol 2021 May 2. Epub 2021 May 2.

Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang, China.

Various cells within the adrenal microenvironment are important in maintaining the body homeostasis. However, our understanding of adrenal disease pathogenesis is limited by an incomplete molecular characterization of the cell types responsible for the organ's multiple homeostatic functions. We report a cellular landscape of the human adrenal gland using single-cell RNA sequencing. Read More

View Article and Full-Text PDF

Commentary on Apparent Bilateral Adrenal Suppression.

Barry A Sacks

J Vasc Interv Radiol 2021 05;32(5):666-667

Department of Interventional Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. Electronic address:

View Article and Full-Text PDF

Characteristics of Li-Fraumeni Syndrome in Japan; A Review Study by the Special Committee of JSHT.

Cancer Sci 2021 May 1. Epub 2021 May 1.

Division of Genetic Medicine, Master of Science, Graduate School of Science and Engineering Research, Kindai University, Japan.

Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome, and the majority of patients with LFS have been identified with germline variants in the p53 tumor suppressor (TP53) gene. In the past three decades, considerable case reports of TP53 germline variants have been published in Japan. To the best of our knowledge, there have been no large-scale studies of Japanese patients with LFS. Read More

View Article and Full-Text PDF

Extrahepatic alveolar echinococcus on multi-slice computed tomography and magnetic resonance imaging.

Sci Rep 2021 Apr 30;11(1):9409. Epub 2021 Apr 30.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Medical Imaging Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People's Republic of China.

Alveolar echinococcus (AE) is a severe health problem in endemic areas. In recent years, the incidence of this disease in China has been increasing. The study was designed to illustrate the multi-slice computed tomography (MSCT) and magnetic resonance imaging (MRI) features of extrahepatic AE. Read More

View Article and Full-Text PDF

Ultrasound-guided fine needle aspiration biopsy (FNAB) demonstrating upper distal extremity metastasis of lung adenocarcinoma: a case report and review of the literature.

Eur Rev Med Pharmacol Sci 2021 Apr;25(8):3221-3225

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Due to early metastasis and delayed diagnosis, lung cancer is the leading cause of cancer-related deaths. Although the most common metastasis sites are brain, bone, lung, adrenal glands, liver, and extra-thoracic lymph node, soft tissues, such as skeletal muscles, skin, and subcutaneous tissues, can also be undermined. This article aims to report the first case of an asymptomatic radial extensor muscle metastasis generating from a lung adenocarcinoma that was diagnosed by ultrasound-guided fine-needle aspiration biopsy (FNAB). Read More

View Article and Full-Text PDF

Retrospective Cohort Study of Intraoperative Administration of Sustained-Release 5-Fluorouracil Implants in Advanced Gastric Cancer Patients.

Front Pharmacol 2021 13;12:659258. Epub 2021 Apr 13.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.

5-fluorouracil (5-FU) is basically used in the field of postoperative chemotherapy of gastric cancer (GC), the goal of this study was to evaluate improvement of long-term survival rate among GC patients after the 5-FU implants treatment. The study included 145 patients with gastric cancer who received postoperative chemotherapy with 5-FU implants and had complete follow-up information. According to the sex, age and clinical stage of 5-FU implants group, 74 patients were matched as the control group at the same time. Read More

View Article and Full-Text PDF

DNA Methylation of the Angiotensinogen Gene, , and the Aldosterone Synthase Gene, in Cardiovascular Diseases.

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Department of Endocrinology and Metabolism, Kanazawa University Hospital, Kanazawa 920-8641, Japan.

Angiotensinogen (AGT) and aldosterone play key roles in the regulation of blood pressure and are implicated in the pathogenesis of cardiovascular diseases. DNA methylation typically acts to repress gene transcription. The aldosterone synthase gene is regulated by angiotensin II and potassium. Read More

View Article and Full-Text PDF

Positive Correlation between nNOS and Stress-Activated Bowel Motility Is Confirmed by In Vivo HiBiT System.

Cells 2021 Apr 27;10(5). Epub 2021 Apr 27.

Graduate School of International Agricultural Technology and Green, Institute of Green BioScience and Technology, Seoul National University, 1447 Pyeongchang-ro, Daewha, Pyeongchang 25354, Korea.

Neuronal nitric oxide synthase (nNOS) has various roles as a neurotransmitter. However, studies to date have produced insufficient data to fully support the correlation between nNOS and bowel motility. This study aimed to investigate the correlation between nNOS expression and gastrointestinal (GI) tract motility using a stress-induced neonatal maternal separation (NMS) mouse model. Read More

View Article and Full-Text PDF

Mineralocorticoid Receptor Antagonists Eplerenone and Spironolactone Modify Adrenal Cortex Morphology and Physiology.

Biomedicines 2021 Apr 20;9(4). Epub 2021 Apr 20.

Department of Experimental Biology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.

Mineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to evaluate whether the MRAs spironolactone and eplerenone influence adrenal cortical physiology and morphology. Spontaneous hypertensive rats (SHR, = 18) and normotensive rats (WKY, = 18) were randomly exposed to a daily dose of spironolactone ( = 6), eplerenone ( = 6), or no drug ( = 6) over 28 days. Read More

View Article and Full-Text PDF

The Gut Microbiota Affects Corticosterone Production in the Murine Small Intestine.

Int J Mol Sci 2021 Apr 19;22(8). Epub 2021 Apr 19.

Institute of Physiology, Czech Academy of Sciences, CZ-142 20 Prague, Czech Republic.

Glucocorticoids (GCs) are hormones that are released in response to stressors and exhibit many activities, including immunomodulatory and anti-inflammatory activities. They are primarily synthesized in the adrenal gland but are also produced in peripheral tissues via regeneration of adrenal 11-oxo metabolites or by synthesis from cholesterol. The present study investigated the influence of the microbiota on steroidogenesis and regeneration of corticosterone in the intestine of germ-free (GF) and specific pathogen-free mice challenged with a physical stressor (anti-CD3 antibody i. Read More

View Article and Full-Text PDF

The Enigma of the Adrenarche: Identifying the Early Life Mechanisms and Possible Role in Postnatal Brain Development.

Int J Mol Sci 2021 Apr 21;22(9). Epub 2021 Apr 21.

School of Health & Biomedical Sciences, Bundoora Campus, RMIT University, Melbourne, VIC 3083, Australia.

Dehydroepiandrosterone (DHEA) and its sulfated metabolite (DHEAS) are dynamically regulated before birth and the onset of puberty. Yet, the origins and purpose of increasing DHEA[S] in postnatal development remain elusive. Here, we draw attention to this pre-pubertal surge from the adrenal gland-the adrenarche-and discuss whether this is the result of intra-adrenal gene expression specifically affecting the zona reticularis (ZR), if the ZR is influenced by the hypothalamic-pituitary axis, and the possible role of spino-sympathetic innervation in prompting increased ZR activity. Read More

View Article and Full-Text PDF

Epithelial and Mesenchymal Markers in Adrenocortical Tissues: How Mesenchymal Are Adrenocortical Tissues?

Cancers (Basel) 2021 Apr 6;13(7). Epub 2021 Apr 6.

Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, 97080 Würzburg, Germany.

A clinically relevant proportion of adrenocortical carcinoma (ACC) cases shows a tendency to metastatic spread. The objective was to determine whether the epithelial to mesenchymal transition (EMT), a mechanism associated with metastasizing in several epithelial cancers, might play a crucial role in ACC. 138 ACC, 29 adrenocortical adenomas (ACA), three normal adrenal glands (NAG), and control tissue samples were assessed for the expression of epithelial (E-cadherin and EpCAM) and mesenchymal (N-cadherin, SLUG and SNAIL) markers by immunohistochemistry. Read More

View Article and Full-Text PDF

Targeted RNA sequencing of adrenal zones using immunohistochemistry-guided capture of formalin-fixed paraffin-embedded tissue.

Mol Cell Endocrinol 2021 Apr 26;530:111296. Epub 2021 Apr 26.

Michigan Center for Translational Pathology, Ann Arbor, MI, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Adequate access to fresh or frozen normal adrenal tissue has been a primary limitation to the enhanced characterization of the adrenal zones via RNA sequencing (RNAseq). Herein, we describe the application of targeted RNAseq to formalin-fixed paraffin-embedded (FFPE) normal adrenal gland specimens. Immunohistochemistry (IHC) was used to visualize and guide the capture of the adrenocortical zones and medulla. Read More

View Article and Full-Text PDF

Morphological and histological studies of the adrenal gland in the Japanese quail (Coturnix japonica).

Microsc Res Tech 2021 Apr 27. Epub 2021 Apr 27.

Department of Anatomy and Histology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.

The adrenal gland is a vital endocrine gland that secretes many important hormones in everyday bird life. The adrenal gland of the Japanese quail is grossly located ventromedially the corresponding kidney and has a creamy to yellow color. The quail gland is surrounded by a capsule and contains some ganglionic cells, and the capsule is characterized by the presence of chromaffin cells. Read More

View Article and Full-Text PDF

Glucocorticoids are double-edged sword in the treatment of COVID-19 and cancers.

Int J Biol Sci 2021 10;17(6):1530-1537. Epub 2021 Apr 10.

Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, and Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.

Glucocorticoids are important steroid hormones. As an outstanding scientific discovery, the scientist who discovered glucocorticoids was awarded the Nobel Prize in Physiology and Medicine in 1950. Cortisone (hydrocortisone) is a natural glucocorticoid, which is secreted with circadian rhythm by the cortical cells of adrenal glands. Read More

View Article and Full-Text PDF

Neuroblastoma metastasized to the mandible and the spinal extradural regions: A case report.

Medicine (Baltimore) 2021 Apr;100(17):e24399

Cancer Center.

Abstract: Neuroblastoma (NB) metastasized into the mandible and spinal extradural region was rarely reported. We present a case with metastatic NB to the mandible and the spinal extradural regions. The patient received chemotherapy using NB 97 regimen and was tumor free after 8 months, but 9 months after the treatment, the patient presented with lower limb paralysis and persistent pain in maxillofacial region as well as swelling in the left mandibular area. Read More

View Article and Full-Text PDF